MCID: BRN007
MIFTS: 24

Brain Oligodendroglioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Oligodendroglioma

MalaCards integrated aliases for Brain Oligodendroglioma:

Name: Brain Oligodendroglioma 12 15 71
Oligodendroglioma of Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3187
NCIt 49 C9377
SNOMED-CT 67 254940005
UMLS 71 C0346286

Summaries for Brain Oligodendroglioma

Disease Ontology : 12 A brain glioma that has material basis in oligodendrocytes.

MalaCards based summary : Brain Oligodendroglioma, also known as oligodendroglioma of brain, is related to oligodendroglioma and adult oligodendroglioma, and has symptoms including seizures and headache. An important gene associated with Brain Oligodendroglioma is FAM83H (Family With Sequence Similarity 83 Member H), and among its related pathways/superpathways are Neural Crest Differentiation and Neural Stem Cells and Lineage-specific Markers. The drugs Everolimus and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Brain Oligodendroglioma

Diseases related to Brain Oligodendroglioma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 oligodendroglioma 29.0 SOX10 OLIG2
2 adult oligodendroglioma 11.5
3 corpus callosum oligodendroglioma 11.2
4 juvenile pilocytic astrocytoma 9.4 SOX10 OLIG2
5 cerebral degeneration 9.2 SOX10 OLIG2

Graphical network of the top 20 diseases related to Brain Oligodendroglioma:



Diseases related to Brain Oligodendroglioma

Symptoms & Phenotypes for Brain Oligodendroglioma

UMLS symptoms related to Brain Oligodendroglioma:


seizures, headache

GenomeRNAi Phenotypes related to Brain Oligodendroglioma according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.4 DCX
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.4 SOX10
3 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.4 DCX
4 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.4 SOX10
5 Increased shRNA abundance (Z-score > 2) GR00366-A-18 9.4 SOX10
6 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.4 DCX
7 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.4 SOX10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.4 DCX
9 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.4 SOX10
10 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.4 SOX10
11 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.4 SOX10
12 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.4 DCX

MGI Mouse Phenotypes related to Brain Oligodendroglioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.35 DCX FAM83H ITGA11 OLIG2 SOX10
2 mortality/aging MP:0010768 9.1 DCX FAM83H ITGA11 OLIG2 SOX10 VASN

Drugs & Therapeutics for Brain Oligodendroglioma

Drugs for Brain Oligodendroglioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Early Phase 1 159351-69-6 70789204 6442177
2
Temozolomide Approved, Investigational Early Phase 1 85622-93-1 5394
3
Lapatinib Approved, Investigational Early Phase 1 231277-92-2, 388082-78-8 208908 9941095
4
Lomustine Approved, Investigational Early Phase 1 13010-47-4 3950
5
Irinotecan Approved, Investigational Early Phase 1 97682-44-5, 100286-90-6 60838
6
Osimertinib Approved Early Phase 1 1421373-65-0 71496458
7
Carboplatin Approved Early Phase 1 41575-94-4 10339178 38904 498142

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Pilot Study of an Implantable Microdevice for In Situ Evaluation of Drug Response in Patients With Primary Brain Tumors Recruiting NCT04135807 Early Phase 1

Search NIH Clinical Center for Brain Oligodendroglioma

Genetic Tests for Brain Oligodendroglioma

Anatomical Context for Brain Oligodendroglioma

MalaCards organs/tissues related to Brain Oligodendroglioma:

40
Brain, Bone Marrow, Bone, Breast

Publications for Brain Oligodendroglioma

Articles related to Brain Oligodendroglioma:

# Title Authors PMID Year
1
The Korean Society for Neuro-Oncology (KSNO) Guideline for WHO Grade II Cerebral Gliomas in Adults: Version 2019.01. 61
31686437 2019
2
Use of Aromatase Inhibitors in IVF for Fertility Preservation of Non-Breast Cancer Patients: A Case Series. 61
29527850 2018
3
Molecular diagnosis of metastasizing oligodendroglioma: a case report. 61
14736827 2004
4
High-dose thiotepa with autologous bone marrow rescue in recurrent malignant oligodendroglioma: a case report. 61
2120394 1990
5
WEEKLY clinicopathologic exercises: brain oligodendroglioma of the right parietal region. 61
13087590 1953
6
Primary Oligodendroglioma of Brain with Spinal Metastasis. 61
19990435 1935

Variations for Brain Oligodendroglioma

Expression for Brain Oligodendroglioma

Search GEO for disease gene expression data for Brain Oligodendroglioma.

Pathways for Brain Oligodendroglioma

Pathways related to Brain Oligodendroglioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 SOX10 OLIG2
2 10.52 SOX10 OLIG2

GO Terms for Brain Oligodendroglioma

Biological processes related to Brain Oligodendroglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oligodendrocyte differentiation GO:0048709 8.62 SOX10 OLIG2

Sources for Brain Oligodendroglioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....