MCID: BRN007
MIFTS: 26

Brain Oligodendroglioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Oligodendroglioma

MalaCards integrated aliases for Brain Oligodendroglioma:

Name: Brain Oligodendroglioma 12 15 71
Oligodendroglioma of Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3187
NCIt 49 C9377
UMLS 71 C0346286

Summaries for Brain Oligodendroglioma

Disease Ontology : 12 A brain glioma that has material basis in oligodendrocytes.

MalaCards based summary : Brain Oligodendroglioma, also known as oligodendroglioma of brain, is related to oligodendroglioma and adult oligodendroglioma, and has symptoms including seizures and headache. An important gene associated with Brain Oligodendroglioma is DCX (Doublecortin), and among its related pathways/superpathways are Neural Crest Differentiation and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Irinotecan and Sirolimus have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Brain Oligodendroglioma

Graphical network of the top 20 diseases related to Brain Oligodendroglioma:



Diseases related to Brain Oligodendroglioma

Symptoms & Phenotypes for Brain Oligodendroglioma

UMLS symptoms related to Brain Oligodendroglioma:


seizures, headache

GenomeRNAi Phenotypes related to Brain Oligodendroglioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.1 DCX
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.1 DCX SOX10
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.1 SOX10
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 9.1 DCX
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.1 SOX10

Drugs & Therapeutics for Brain Oligodendroglioma

Drugs for Brain Oligodendroglioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Irinotecan Approved, Investigational Early Phase 1 97682-44-5, 100286-90-6 60838
2
Sirolimus Approved, Investigational Early Phase 1 53123-88-9 5284616 6436030 46835353
3
Everolimus Approved Early Phase 1 159351-69-6 6442177 70789204
4
Osimertinib Approved Early Phase 1 1421373-65-0 71496458
5
Lapatinib Approved, Investigational Early Phase 1 231277-92-2, 388082-78-8 208908 9941095
6
Temozolomide Approved, Investigational Early Phase 1 85622-93-1 5394
7
Carboplatin Approved Early Phase 1 41575-94-4 10339178 498142 38904
8
Lomustine Approved, Investigational Early Phase 1 13010-47-4 3950
9 Protein Kinase Inhibitors Early Phase 1
10 Alkylating Agents Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Pilot Study of an Implantable Microdevice for In Situ Evaluation of Drug Response in Patients With Primary Brain Tumors Not yet recruiting NCT04135807 Early Phase 1

Search NIH Clinical Center for Brain Oligodendroglioma

Genetic Tests for Brain Oligodendroglioma

Anatomical Context for Brain Oligodendroglioma

MalaCards organs/tissues related to Brain Oligodendroglioma:

40
Brain, Bone, Bone Marrow, Breast

Publications for Brain Oligodendroglioma

Articles related to Brain Oligodendroglioma:

# Title Authors PMID Year
1
The Korean Society for Neuro-Oncology (KSNO) Guideline for WHO Grade II Cerebral Gliomas in Adults: Version 2019.01. 61
31686437 2019
2
Use of Aromatase Inhibitors in IVF for Fertility Preservation of Non-Breast Cancer Patients: A Case Series. 61
29527850 2018
3
Molecular diagnosis of metastasizing oligodendroglioma: a case report. 61
14736827 2004
4
High-dose thiotepa with autologous bone marrow rescue in recurrent malignant oligodendroglioma: a case report. 61
2120394 1990
5
WEEKLY clinicopathologic exercises: brain oligodendroglioma of the right parietal region. 61
13087590 1953
6
Primary Oligodendroglioma of Brain with Spinal Metastasis. 61
19990435 1935

Variations for Brain Oligodendroglioma

Expression for Brain Oligodendroglioma

Search GEO for disease gene expression data for Brain Oligodendroglioma.

Pathways for Brain Oligodendroglioma

Pathways related to Brain Oligodendroglioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 SOX10 OLIG2
2 10.7 SOX10 OLIG2 NES

GO Terms for Brain Oligodendroglioma

Biological processes related to Brain Oligodendroglioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 central nervous system development GO:0007417 9.16 NES DCX
2 nervous system development GO:0007399 9.13 OLIG2 NES DCX
3 oligodendrocyte differentiation GO:0048709 8.62 SOX10 OLIG2

Sources for Brain Oligodendroglioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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