MCID: BRN021
MIFTS: 33

Brain Sarcoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Sarcoma

MalaCards integrated aliases for Brain Sarcoma:

Name: Brain Sarcoma 12 15 74
Sarcoma of the Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2132
NCIt 51 C5154
UMLS 74 C1332607

Summaries for Brain Sarcoma

Disease Ontology : 12 A brain cancer that is characterized by abnormally proliferating cells, derives from embryonic mesoderm.

MalaCards based summary : Brain Sarcoma, also known as sarcoma of the brain, is related to reticulum cell sarcoma and interdigitating dendritic cell sarcoma. An important gene associated with Brain Sarcoma is NSD2 (Nuclear Receptor Binding SET Domain Protein 2), and among its related pathways/superpathways are NF-kappaB Signaling and Dendritic Cells Developmental Lineage Pathway. The drugs nivolumab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include brain, myeloid and skin, and related phenotype is hematopoietic system.

Related Diseases for Brain Sarcoma

Diseases related to Brain Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 reticulum cell sarcoma 10.3
2 interdigitating dendritic cell sarcoma 10.1 CD163 PTPRC
3 myeloid sarcoma 10.1
4 histiocytic and dendritic cell cancer 10.1 CD163 PTPRC
5 sarcoma 10.0
6 histiocytic sarcoma 10.0
7 nodular tenosynovitis 10.0 CD68 PTPRC
8 extracutaneous mastocytoma 10.0 CD68 PTPRC
9 malignant giant cell tumor of soft parts 10.0 CD68 PTPRC
10 erythema elevatum diutinum 9.9 CD68 PECAM1
11 glomeruloid hemangioma 9.9 CD68 PTPRC
12 central nervous system sarcoma 9.9 CD163 CD68
13 synovitis 9.9 CD163 CD68
14 conventional fibrosarcoma 9.9 CD68 PTPRC
15 adult xanthogranuloma 9.9 CD163 CD68
16 lymphoplasmacyte-rich meningioma 9.9 CD163 CD68
17 hodgkin's lymphoma, lymphocytic depletion 9.9 CD68 PTPRC
18 spleen cancer 9.9 CD163 CD68
19 balloon cell malignant melanoma 9.9 CD68 MLANA
20 trigeminal nerve neoplasm 9.9 CD68 PTPRC
21 histiocytosis 9.9 CD163 PTPRC
22 petroclival meningioma 9.9 CD163 CD68
23 neurilemmoma of the fifth cranial nerve 9.9 CD68 PTPRC
24 diffuse meningeal melanocytosis 9.9 CD68 MLANA
25 giant cell glioblastoma 9.8
26 spindle cell sarcoma 9.8
27 dendritic cell tumor 9.8 CD68 PTPRC
28 myxosarcoma 9.8 CD68 MLANA
29 sarcomatoid squamous cell skin carcinoma 9.8 CD68 MLANA
30 skin sarcoma 9.8 CD163 CD68
31 meningeal melanocytoma 9.8 CD68 MLANA
32 melkersson-rosenthal syndrome 9.8 CD68 PTPRC
33 histiocytoma 9.8 CD163 PTPRC
34 enterobiasis 9.8 CD163 CD68
35 reticulohistiocytic granuloma 9.7 CD163 CD68 PTPRC
36 multiple sclerosis 9.7
37 osteogenic sarcoma 9.7
38 wiskott-aldrich syndrome 9.7
39 leukemia, acute myeloid 9.7
40 ewing sarcoma 9.7
41 myelodysplastic syndrome 9.7
42 uveitis 9.7
43 optic nerve disease 9.7
44 myeloid leukemia 9.7
45 neuropathy 9.7
46 glioma 9.7
47 central nervous system melanocytic neoplasm 9.7 CD68 MLANA
48 acute lymphocytic leukemia 9.6
49 leukemia 9.6
50 lymphocytic leukemia 9.6

Graphical network of the top 20 diseases related to Brain Sarcoma:



Diseases related to Brain Sarcoma

Symptoms & Phenotypes for Brain Sarcoma

MGI Mouse Phenotypes related to Brain Sarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.1 CD163 CD68 JUN PECAM1 PTPRC TSC22D1

Drugs & Therapeutics for Brain Sarcoma

Drugs for Brain Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Antibodies Phase 2
3 Antineoplastic Agents, Immunological Phase 2
4 Immunoglobulins Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immune Checkpoint Inhibitor Nivolumab in People With Select Rare CNS Cancers Recruiting NCT03173950 Phase 2 Nivolumab

Search NIH Clinical Center for Brain Sarcoma

Genetic Tests for Brain Sarcoma

Anatomical Context for Brain Sarcoma

MalaCards organs/tissues related to Brain Sarcoma:

42
Brain, Myeloid, Skin, Kidney, Bone, Spleen

Publications for Brain Sarcoma

Articles related to Brain Sarcoma:

(show all 49)
# Title Authors Year
1
Primary Histiocytic Sarcoma of the Brain in an African Hedgehog (Atelerix albiventris). ( 29169617 )
2017
2
Use of magnetic resonance imaging for diagnosis and after treatment of patients with myeloid sarcoma of the brain. ( 29254273 )
2017
3
Rhabdoid sarcoma of the brain in adults: which treatment? ( 24220320 )
2014
4
Primary histiocytic sarcoma of the brain mimicking cerebral abscess. ( 23889356 )
2013
5
Histiocytic sarcoma of the brain. ( 22831650 )
2012
6
Metastatic brain sarcoma with gliomatous component. ( 21833576 )
2011
7
Primary brain sarcoma or metastatic carcinoma? ( 19346656 )
2009
8
Multifocal Ewing's sarcoma of the brain, calvarium, leptomeninges, spine and other bones in a child. ( 18468902 )
2008
9
Primary Ewing sarcoma of the brain: a case report and literature review. ( 17525681 )
2007
10
Granulocytic sarcoma of the brain in a patient with acute myeloid leukemia. ( 16018381 )
2004
11
Isolated recurrence of granulocytic sarcoma of the brain: successful treatment with surgical resection, intrathecal injection, irradiation and prophylactic systemic chemotherapy. ( 10340046 )
1999
12
A case of granulocytic sarcoma of the brain in a patient with myelodysplastic syndrome. ( 7495777 )
1995
13
Histiocytic sarcoma of the brain in childhood. ( 3595622 )
1987
14
Granulocytic sarcoma of the brain: a case report and review of the literature. ( 3459211 )
1986
15
Brain sarcoma of meningeal origin after cranial irradiation in childhood acute lymphocytic leukemia. Case report. ( 6590801 )
1984
16
Primary reticulum cell sarcoma of the brain presenting as steroid-responsive optic neuropathy. ( 6233304 )
1984
17
Granulocytic sarcoma of the brain after renal transplantation. ( 6752351 )
1982
18
On the nature of the so-called monstrocellular sarcoma of the brain. ( 6993985 )
1980
19
Computed tomography in primary reticulum cell sarcoma of the brain. ( 364530 )
1979
20
Clinical and radiologic remission in reticulum cell sarcoma of the brain. ( 371595 )
1979
21
Amaurosis and primary reticulum cell sarcoma of the brain: clinicopathologic study of a case. ( 343261 )
1978
22
Differences in 111In uptake in mouse brain sarcoma based on form of administration. ( 863574 )
1977
23
Primary reticulum cell sarcoma of the brain in Wiskott-Aldrich syndrome. Report of a case. ( 334130 )
1977
24
Granulocytic sarcoma of the brain. ( 265745 )
1977
25
Primary osteogenic sarcoma of the brain. Case report. ( 1059735 )
1976
26
A patient with so-called primary reticulum cell sarcoma of the brain with 6.5 years' survival, treated as 'meningeal leukaemia'. ( 800969 )
1976
27
3H-thymidine autoradiography of CSF cells in primary reticulum cell sarcoma of the brain. ( 51071 )
1975
28
Reticulum cell sarcoma of the brain. A review of the literature and a study of 19 cases. ( 1091348 )
1975
29
Primary reticulum-cell-sarcoma of the brain. A clinical-pathological study. ( 1093769 )
1975
30
Proceedings: Periadventitial sarcoma of the brain: a simulator of multiple sclerosis. ( 1181881 )
1975
31
Kaposi's sarcoma of the brain. A case report with necropsy findings. ( 1182666 )
1975
32
Primary reticulum cell sarcoma of the brain in a renal transplantation recipient. ( 4601706 )
1974
33
Congenital sarcoma of the brain. Diagnosis during the neonatal period. ( 4547167 )
1974
34
Ultrastructure of a composite glioma-sarcoma of the brain. ( 4698526 )
1973
35
The kinetics of 99m Tc-, 113m In-, and 169 Yb-DTPA compounds in brain sarcoma and kidneys of mice. ( 5058238 )
1972
36
Primary reticulum cell sarcoma of the brain stem. ( 4551933 )
1972
37
Uveitis associated with isolated reticulum cell sarcoma of the brain. ( 4552081 )
1972
38
The effect of perchlorate on the localization of 99mTc-pertechnetate in a mouse brain sarcoma. ( 4317181 )
1970
39
Monstrocellular sarcoma of the brain: 6-year postoperative survival. Case report. ( 5359216 )
1969
40
Reticuloendothelial sarcoma of the brain. Report of four cases. ( 4876448 )
1968
41
Reticuloendothelial (perivascular) sarcoma of the brain. ( 5335364 )
1966
42
PRIMARY RETICULUM-CELL SARCOMA OF THE BRAIN. ( 14184996 )
1963
43
Sarcoma of the brain. A study of two cases in children and experimental production of similar tumors in chick brain. ( 13912659 )
1962
44
Reticulum cell sarcoma of the brain; a clinicopathologic report. ( 13349057 )
1956
45
Perithelial sarcoma of the brain; a clinicopathological study of thirteen cases. ( 13157703 )
1954
46
Primary Hodgkin's sarcoma of the brain. ( 20999932 )
1946
47
Case of Round-Cell Sarcoma of the Brain Situated in the Frontal Lobes, and Beginning with Mental Symptoms. ( 30438891 )
1906
48
A Case of Sarcoma of the Brain Removed by Operation: Subsequent Operation for Removal of A Second Tumour: Recovery. ( 20759548 )
1901
49
A Case of Successful Removal of a Large Sarcoma of the Brain. ( 30436182 )
1897

Variations for Brain Sarcoma

Expression for Brain Sarcoma

Search GEO for disease gene expression data for Brain Sarcoma.

Pathways for Brain Sarcoma

GO Terms for Brain Sarcoma

Cellular components related to Brain Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 CD163 PECAM1 PTPRC
2 cell periphery GO:0071944 8.62 PECAM1 PTPRC

Biological processes related to Brain Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte cell-cell adhesion GO:0007159 9.16 PECAM1 PTPRC
2 positive regulation of T cell mediated cytotoxicity GO:0001916 8.96 CD1E PTPRC
3 negative regulation of protein autophosphorylation GO:0031953 8.62 JUN PTPRC

Sources for Brain Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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