MCID: BRN021
MIFTS: 26

Brain Sarcoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Sarcoma

MalaCards integrated aliases for Brain Sarcoma:

Name: Brain Sarcoma 12 15 70
Sarcoma of the Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2132
NCIt 50 C5154
UMLS 70 C1332607

Summaries for Brain Sarcoma

Disease Ontology : 12 A brain cancer that is characterized by abnormally proliferating cells, derives from embryonic mesoderm.

MalaCards based summary : Brain Sarcoma, also known as sarcoma of the brain, is related to reticulum cell sarcoma and myeloid sarcoma. An important gene associated with Brain Sarcoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are DNA Damage and Nucleotide excision repair. Affiliated tissues include brain, myeloid and spinal cord, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Brain Sarcoma

Diseases related to Brain Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 reticulum cell sarcoma 10.5
2 myeloid sarcoma 10.3
3 giant cell glioblastoma 10.2
4 histiocytic sarcoma 10.2
5 rare tumor 10.2
6 leukemia, acute myeloid 10.0
7 meningioma, familial 10.0
8 intracranial meningioma 10.0
9 uveitis 10.0
10 secretory meningioma 10.0
11 lymphoplasmacyte-rich meningioma 10.0
12 cerebellum cancer 10.0 TP53 KIAA1549
13 adult astrocytic tumour 10.0 TP53 KIAA1549
14 gliofibroma 10.0 TP53 KIAA1549
15 salivary gland carcinoma 10.0 TSC22D1 TP53
16 high grade ependymoma 10.0 TP53 KIAA1549
17 supratentorial cancer 10.0 TP53 KIAA1549
18 pleomorphic xanthoastrocytoma 10.0 TP53 KIAA1549
19 sarcoma 10.0
20 spindle cell sarcoma 10.0
21 diffuse astrocytoma 10.0 TP53 KIAA1549
22 diffuse midline glioma, h3 k27m-mutant 9.9 TP53 KIAA1549
23 central nervous system benign neoplasm 9.9 TP53 KIAA1549
24 conjunctival degeneration 9.9 XPA TP53
25 mutagen sensitivity 9.9 XPA TP53
26 kaposi sarcoma 9.9
27 medulloblastoma 9.9
28 myelofibrosis 9.9
29 osteogenic sarcoma 9.9
30 wiskott-aldrich syndrome 9.9
31 ewing sarcoma 9.9
32 myelodysplastic syndrome 9.9
33 central nervous system primitive neuroectodermal neoplasm 9.9
34 osteomyelitis 9.9
35 hemiplegia 9.9
36 optic neuritis 9.9
37 posterior uveitis 9.9
38 multiple cranial nerve palsy 9.9
39 neuritis 9.9
40 optic nerve disease 9.9
41 extraosseous ewing sarcoma 9.9
42 supratentorial primitive neuroectodermal tumor 9.9
43 paraplegia 9.9
44 myeloid leukemia 9.9
45 neuropathy 9.9
46 acute myeloblastic leukemia with maturation 9.9
47 glioma 9.9
48 soft tissue sarcoma 9.9
49 glial tumor 9.9
50 pilocytic astrocytoma 9.9 TP53 KIAA1549

Graphical network of the top 20 diseases related to Brain Sarcoma:



Diseases related to Brain Sarcoma

Symptoms & Phenotypes for Brain Sarcoma

GenomeRNAi Phenotypes related to Brain Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.1 GPN1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.1 GPN1 TP53
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.1 GPN1 RAD23A TP53

Drugs & Therapeutics for Brain Sarcoma

Search Clinical Trials , NIH Clinical Center for Brain Sarcoma

Genetic Tests for Brain Sarcoma

Anatomical Context for Brain Sarcoma

MalaCards organs/tissues related to Brain Sarcoma:

40
Brain, Myeloid, Spinal Cord, Testis

Publications for Brain Sarcoma

Articles related to Brain Sarcoma:

(show top 50) (show all 96)
# Title Authors PMID Year
1
[Primary alveolar soft tissue sarcoma of the brain and lung: report of two cases]. 61
33677896 2021
2
A scoping review of trials of interventions led or delivered by cancer nurses. 61
29960894 2018
3
Primary Histiocytic Sarcoma of the Brain in an African Hedgehog (Atelerix albiventris). 61
29169617 2017
4
Use of magnetic resonance imaging for diagnosis and after treatment of patients with myeloid sarcoma of the brain. 61
29254273 2017
5
Enterobacter Meningitis and Challenges in Treatment. 61
28208914 2016
6
Proton Therapy Facility Planning From a Clinical and Operational Model. 61
24988058 2015
7
Assessment of uncertainties in radiation-induced cancer risk predictions at clinically relevant doses. 61
25563249 2015
8
Rhabdoid sarcoma of the brain in adults: which treatment? 61
24220320 2014
9
Primary histiocytic sarcoma of the brain mimicking cerebral abscess. 61
23889356 2013
10
Histiocytic sarcoma of the brain. 61
22831650 2012
11
Metastatic brain sarcoma with gliomatous component. 61
21833576 2011
12
18F-fluorodeoxyglucose positron emission tomography and magnetic resonance imaging findings of primary intracranial histiocytic sarcoma in a dog. 61
19887750 2009
13
Primary brain sarcoma or metastatic carcinoma? 61
19346656 2009
14
Multifocal Ewing's sarcoma of the brain, calvarium, leptomeninges, spine and other bones in a child. 61
18468902 2008
15
[Granulocytic sarcoma of the brain revealed on vascular mode]. 61
18565363 2008
16
Primary Ewing sarcoma of the brain: a case report and literature review. 61
17525681 2007
17
Granulocytic sarcoma of the brain in a patient with acute myeloid leukemia. 61
16018381 2004
18
[Myeloid sarcoma of the brain. A case report]. 61
12743502 2003
19
Downregulation of putative tumor suppressor gene TSC-22 in human brain tumors. 61
12501169 2003
20
Adoptive immunotherapy for malignant brain tumors using human peripheral blood mononuclear cells activated by the Streptococcal preparation OK-432. 61
11561349 2001
21
Primary composite angiogenic leiomyosarcoma-epithelioid angiosarcoma of the brain. 61
11071573 2000
22
Isolated recurrence of granulocytic sarcoma of the brain: successful treatment with surgical resection, intrathecal injection, irradiation and prophylactic systemic chemotherapy. 61
10340046 1999
23
Eosinophilia and granulocytic dysplasia terminating in acute myeloid leukaemia after 24 years. 61
8943897 1996
24
A case of granulocytic sarcoma of the brain in a patient with myelodysplastic syndrome. 61
7495777 1995
25
Carcinosarcomas of the female genital tract. A pathologic study of 29 metastatic tumors: further evidence for the dominant role of the epithelial component and the conversion theory of histogenesis. 61
7755153 1995
26
[Monstro-cellular sarcoma of the brain]. 61
3673430 1987
27
Histiocytic sarcoma of the brain in childhood. 61
3595622 1987
28
Granulocytic sarcoma of the brain: a case report and review of the literature. 61
3459211 1986
29
Brain sarcoma of meningeal origin after cranial irradiation in childhood acute lymphocytic leukemia. Case report. 61
6590801 1984
30
Primary reticulum cell sarcoma of the brain presenting as steroid-responsive optic neuropathy. 61
6233304 1984
31
Granulocytic sarcoma of the brain after renal transplantation. 61
6752351 1982
32
[Primary sarcoma of the brain with enlargement of the internal auditory canal in a child]. 61
6984094 1982
33
[Reticulum cell sarcoma of the brain with bilateral ocular involvement, a case report]. 61
6752743 1982
34
Primary intracranial sarcomas: radiological diagnosis with emphasis on arteriography. 61
7012662 1981
35
Primary reticulum-cell sarcoma (microglioma) of the brain with massive cardiac metastasis. Case report. 61
7000985 1980
36
[Cellular immunity in human brain tumours (author's transl)]. 61
7442895 1980
37
On the nature of the so-called monstrocellular sarcoma of the brain. 61
6993985 1980
38
Clinical and radiologic remission in reticulum cell sarcoma of the brain. 61
371595 1979
39
[Diagnostic value of brain scintigraphy in the early diagnosis of brain sarcoma]. 61
462989 1979
40
Computed tomography in primary reticulum cell sarcoma of the brain. 61
364530 1979
41
Primary brain sarcomas: light and electron microscopic features. 61
568026 1978
42
Amaurosis and primary reticulum cell sarcoma of the brain: clinicopathologic study of a case. 61
343261 1978
43
[Monstrocellular brain sarcoma. An "in vitro" study (author's transl)]. 61
652398 1978
44
Primary reticulum cell sarcoma of the brain in Wiskott-Aldrich syndrome. Report of a case. 61
334130 1977
45
[Clinical, differential diagnostic, and radiologic picture of primary sarcoma of the brain (author's transl)]. 61
333302 1977
46
Granulocytic sarcoma of the brain. 61
265745 1977
47
Differences in 111In uptake in mouse brain sarcoma based on form of administration. 61
863574 1977
48
[Anatomo-clinical considerations on cerebral sarcomas]. 61
799342 1976
49
A patient with so-called primary reticulum cell sarcoma of the brain with 6.5 years' survival, treated as 'meningeal leukaemia'. 61
800969 1976
50
Primary osteogenic sarcoma of the brain. Case report. 61
1059735 1976

Variations for Brain Sarcoma

Expression for Brain Sarcoma

Search GEO for disease gene expression data for Brain Sarcoma.

Pathways for Brain Sarcoma

Pathways related to Brain Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.27 XPA TP53 RAD23A
2
Show member pathways
11.22 XPA RAD23A
3 10.82 XPA TP53

GO Terms for Brain Sarcoma

Cellular components related to Brain Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 host cell nucleus GO:0042025 8.62 XPA RAD23A

Biological processes related to Brain Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.13 XPA TP53 RAD23A
2 nucleotide-excision repair GO:0006289 8.8 XPA TP53 RAD23A

Molecular functions related to Brain Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 damaged DNA binding GO:0003684 8.62 XPA RAD23A

Sources for Brain Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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