MCID: BRN021
MIFTS: 28

Brain Sarcoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Sarcoma

MalaCards integrated aliases for Brain Sarcoma:

Name: Brain Sarcoma 12 15 74
Sarcoma of the Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2132
NCIt 51 C5154
UMLS 74 C1332607

Summaries for Brain Sarcoma

Disease Ontology : 12 A brain cancer that is characterized by abnormally proliferating cells, derives from embryonic mesoderm.

MalaCards based summary : Brain Sarcoma, also known as sarcoma of the brain, is related to reticulum cell sarcoma and myeloid sarcoma. An important gene associated with Brain Sarcoma is NSD2 (Nuclear Receptor Binding SET Domain Protein 2), and among its related pathways/superpathways is NF-kappaB Signaling. Affiliated tissues include brain, kidney and bone, and related phenotype is skeleton.

Related Diseases for Brain Sarcoma

Diseases related to Brain Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 reticulum cell sarcoma 10.3
2 myeloid sarcoma 10.1
3 sarcoma 10.1
4 breast angiosarcoma 10.1 MLANA SMUG1
5 testis seminoma 10.0 PTPRC SMUG1
6 histiocytic sarcoma 10.0
7 lymphosarcoma 10.0 PTPRC SMUG1
8 malignant skin fibrous histiocytoma 10.0 MLANA SMUG1
9 lymphatic system cancer 10.0 PTPRC SMUG1
10 malignant dermis tumor 10.0 MLANA SMUG1
11 erythema elevatum diutinum 10.0 CD68 PECAM1
12 nodular tenosynovitis 9.9 CD68 PTPRC
13 lymphoma, hodgkin, classic 9.9 PTPRC SMUG1
14 extracutaneous mastocytoma 9.9 CD68 PTPRC
15 malignant giant cell tumor of soft parts 9.9 CD68 PTPRC
16 glomeruloid hemangioma 9.9 CD68 PTPRC
17 conventional fibrosarcoma 9.9 CD68 PTPRC
18 hodgkin's lymphoma, lymphocytic depletion 9.9 CD68 PTPRC
19 trigeminal nerve neoplasm 9.9 CD68 PTPRC
20 neurilemmoma of the fifth cranial nerve 9.9 CD68 PTPRC
21 balloon cell malignant melanoma 9.9 CD68 MLANA
22 pulmonary artery leiomyosarcoma 9.9 CD68 SMUG1
23 sternum cancer 9.9 CD68 SMUG1
24 diffuse meningeal melanocytosis 9.9 CD68 MLANA
25 reticulohistiocytic granuloma 9.9 CD68 PTPRC
26 lactocele 9.9 CD68 SMUG1
27 granulomatous myositis 9.9 CD68 SMUG1
28 myeloma, multiple 9.9 NSD2 PTPRC SMUG1
29 dendritic cell tumor 9.9 CD68 PTPRC
30 myxosarcoma 9.9 CD68 MLANA
31 xanthogranulomatous pyelonephritis 9.9 CD68 SMUG1
32 giant cell glioblastoma 9.9
33 sarcomatoid squamous cell skin carcinoma 9.9 CD68 MLANA
34 meningeal melanocytoma 9.9 CD68 MLANA
35 eumycotic mycetoma 9.8 CD68 SMUG1
36 leukocyte disease 9.8 PTPRC SMUG1
37 melkersson-rosenthal syndrome 9.8 CD68 PTPRC
38 xanthogranulomatous cholecystitis 9.8 CD68 SMUG1
39 central nervous system melanocytic neoplasm 9.8 CD68 MLANA
40 photokeratitis 9.7 CD68 JUN PTPRC
41 multiple sclerosis 9.7
42 osteogenic sarcoma 9.7
43 wiskott-aldrich syndrome 9.7
44 leukemia, acute myeloid 9.7
45 ewing sarcoma 9.7
46 myelodysplastic syndrome 9.7
47 uveitis 9.7
48 optic nerve disease 9.7
49 myeloid leukemia 9.7
50 neuropathy 9.7

Graphical network of the top 20 diseases related to Brain Sarcoma:



Diseases related to Brain Sarcoma

Symptoms & Phenotypes for Brain Sarcoma

MGI Mouse Phenotypes related to Brain Sarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 skeleton MP:0005390 9.02 CD68 JUN NSD2 PECAM1 PTPRC

Drugs & Therapeutics for Brain Sarcoma

Search Clinical Trials , NIH Clinical Center for Brain Sarcoma

Genetic Tests for Brain Sarcoma

Anatomical Context for Brain Sarcoma

MalaCards organs/tissues related to Brain Sarcoma:

42
Brain, Kidney, Bone, Myeloid

Publications for Brain Sarcoma

Articles related to Brain Sarcoma:

(show all 38)
# Title Authors Year
1
Metastatic brain sarcoma with gliomatous component. ( 21833576 )
2011
2
Primary brain sarcoma or metastatic carcinoma? ( 19346656 )
2009
3
Multifocal Ewing's sarcoma of the brain, calvarium, leptomeninges, spine and other bones in a child. ( 18468902 )
2008
4
Granulocytic sarcoma of the brain in a patient with acute myeloid leukemia. ( 16018381 )
2004
5
Isolated recurrence of granulocytic sarcoma of the brain: successful treatment with surgical resection, intrathecal injection, irradiation and prophylactic systemic chemotherapy. ( 10340046 )
1999
6
A case of granulocytic sarcoma of the brain in a patient with myelodysplastic syndrome. ( 7495777 )
1995
7
Granulocytic sarcoma of the brain: a case report and review of the literature. ( 3459211 )
1986
8
Brain sarcoma of meningeal origin after cranial irradiation in childhood acute lymphocytic leukemia. Case report. ( 6590801 )
1984
9
Primary reticulum cell sarcoma of the brain presenting as steroid-responsive optic neuropathy. ( 6233304 )
1984
10
Granulocytic sarcoma of the brain after renal transplantation. ( 6752351 )
1982
11
On the nature of the so-called monstrocellular sarcoma of the brain. ( 6993985 )
1980
12
Computed tomography in primary reticulum cell sarcoma of the brain. ( 364530 )
1979
13
Differences in 111In uptake in mouse brain sarcoma based on form of administration. ( 863574 )
1977
14
Granulocytic sarcoma of the brain. ( 265745 )
1977
15
Primary osteogenic sarcoma of the brain. Case report. ( 1059735 )
1976
16
A patient with so-called primary reticulum cell sarcoma of the brain with 6.5 years' survival, treated as 'meningeal leukaemia'. ( 800969 )
1976
17
Reticulum cell sarcoma of the brain. A review of the literature and a study of 19 cases. ( 1091348 )
1975
18
Primary reticulum-cell-sarcoma of the brain. A clinical-pathological study. ( 1093769 )
1975
19
Proceedings: Periadventitial sarcoma of the brain: a simulator of multiple sclerosis. ( 1181881 )
1975
20
Kaposi's sarcoma of the brain. A case report with necropsy findings. ( 1182666 )
1975
21
Primary reticulum cell sarcoma of the brain in a renal transplantation recipient. ( 4601706 )
1974
22
Congenital sarcoma of the brain. Diagnosis during the neonatal period. ( 4547167 )
1974
23
Ultrastructure of a composite glioma-sarcoma of the brain. ( 4698526 )
1973
24
The kinetics of 99m Tc-, 113m In-, and 169 Yb-DTPA compounds in brain sarcoma and kidneys of mice. ( 5058238 )
1972
25
Primary reticulum cell sarcoma of the brain stem. ( 4551933 )
1972
26
Uveitis associated with isolated reticulum cell sarcoma of the brain. ( 4552081 )
1972
27
The effect of perchlorate on the localization of 99mTc-pertechnetate in a mouse brain sarcoma. ( 4317181 )
1970
28
Monstrocellular sarcoma of the brain: 6-year postoperative survival. Case report. ( 5359216 )
1969
29
Reticuloendothelial sarcoma of the brain. Report of four cases. ( 4876448 )
1968
30
Reticuloendothelial (perivascular) sarcoma of the brain. ( 5335364 )
1966
31
PRIMARY RETICULUM-CELL SARCOMA OF THE BRAIN. ( 14184996 )
1963
32
Sarcoma of the brain. A study of two cases in children and experimental production of similar tumors in chick brain. ( 13912659 )
1962
33
Reticulum cell sarcoma of the brain; a clinicopathologic report. ( 13349057 )
1956
34
Perithelial sarcoma of the brain; a clinicopathological study of thirteen cases. ( 13157703 )
1954
35
Primary Hodgkin's sarcoma of the brain. ( 20999932 )
1946
36
Case of Round-Cell Sarcoma of the Brain Situated in the Frontal Lobes, and Beginning with Mental Symptoms. ( 30438891 )
1906
37
A Case of Sarcoma of the Brain Removed by Operation: Subsequent Operation for Removal of A Second Tumour: Recovery. ( 20759548 )
1901
38
A Case of Successful Removal of a Large Sarcoma of the Brain. ( 30436182 )
1897

Variations for Brain Sarcoma

Expression for Brain Sarcoma

Search GEO for disease gene expression data for Brain Sarcoma.

Pathways for Brain Sarcoma

Pathways related to Brain Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.31 MLANA PECAM1 PTPRC

GO Terms for Brain Sarcoma

Cellular components related to Brain Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 8.62 PECAM1 PTPRC

Biological processes related to Brain Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.33 CD68 PECAM1 PTPRC
2 leukocyte cell-cell adhesion GO:0007159 8.96 PECAM1 PTPRC
3 negative regulation of protein autophosphorylation GO:0031953 8.62 JUN PTPRC

Sources for Brain Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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