MCID: BRN048
MIFTS: 38

Brain Stem Cancer

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Brain Stem Cancer

MalaCards integrated aliases for Brain Stem Cancer:

Name: Brain Stem Cancer 12 20 15
Brain Stem Neoplasms 44 70
Malignant Neoplasm of Brain Stem 12
Malignant Neoplasm of Brainstem 12
Brain Stem Neoplasms, Primary 70
Neoplasm of Adult Brain Stem 12
Primary Brain Stem Neoplasm 12
Primary Brain Stem Tumor 12
Neoplasm of Brain Stem 12
Brain Stem Neoplasm 17
Brain Stem--Cancer 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4203
ICD9CM 34 191.7
MeSH 44 D020295
SNOMED-CT 67 126961004 93726004
ICD10 32 C71.7
UMLS 70 C0153641 C0677866 C0751886 more

Summaries for Brain Stem Cancer

MalaCards based summary : Brain Stem Cancer, also known as brain stem neoplasms, is related to adult brain stem glioma and brain stem glioma. An important gene associated with Brain Stem Cancer is KDM4C (Lysine Demethylase 4C), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Temozolomide and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Brain Stem Cancer

Diseases related to Brain Stem Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 adult brain stem glioma 31.8 IDH1 H3-3B H3-3A
2 brain stem glioma 30.0 KDM4C IDH1 H3C6 H3C4 H3C3 H3C2
3 brain stem medulloblastoma 11.0
4 cerebellopontine angle tumor 11.0
5 childhood infratentorial neoplasm 11.0
6 brain stem angioblastoma 11.0
7 malignant giant cell tumor 10.3 H3-3B H3-3A
8 bone giant cell sarcoma 10.3 H3-3B H3-3A
9 telangiectatic osteogenic sarcoma 10.3 H3-3B H3-3A
10 colon leiomyoma 10.2 H3-3B H3-3A
11 juxtacortical chondroma 10.2 KDM4C IDH1
12 spinal cord astrocytoma 10.2 IDH1 H3-3B H3-3A
13 adult oligodendroglioma 10.2 IDH1 H3-3B H3-3A
14 childhood oligodendroglioma 10.2 IDH1 H3-3B H3-3A
15 chondroblastic osteosarcoma 10.2 IDH1 H3-3B H3-3A
16 multiple enchondromatosis, maffucci type 10.2 KDM4C IDH1 H3-3B
17 spinal cord glioma 10.2 IDH1 H3-3B H3-3A
18 pleomorphic xanthoastrocytoma 10.2 IDH1 H3-3B H3-3A
19 alpha thalassemia-x-linked intellectual disability syndrome 10.1 H3-3B H3-3A H2AC18
20 connective tissue benign neoplasm 10.1 H3-3B H3-3A H2AC18
21 bone osteosarcoma 10.1 H3-3B H3-3A H2AC18
22 giant cell glioblastoma 10.1 IDH1 H3-3B H3-3A
23 tonsil squamous cell carcinoma 10.0 H3C12 H3C11 H3C10 H3C1
24 suppression of tumorigenicity 12 10.0 KDM4C IDH1 H2AC18
25 high-grade astrocytoma 10.0 IDH1 ACVR1
26 bile duct adenocarcinoma 10.0 KDM4C IDH1 H2AC18
27 bone sarcoma 10.0 KDM4C IDH1 H2AC18
28 chronic leukemia 10.0 PDGFRA KDM4C H2AC18
29 bile duct disease 10.0 KDM4C IDH1 H2AC18
30 adult astrocytic tumour 9.9 PDGFRA IDH1 H3-3B H3-3A
31 chiari malformation type ii 9.9
32 ocular motor apraxia 9.9
33 chiari malformation 9.9
34 glioma susceptibility 1 9.9 IDH1 H3C1 H3-3A
35 pure autonomic failure 9.9
36 spinal cord oligodendroglioma 9.9 NF1 IDH1
37 kabuki syndrome 1 9.9 KDM6B KDM4C H2AC18
38 clear cell chondrosarcoma 9.8 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18
39 chondroblastoma 9.8 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18
40 cerebellum cancer 9.8 NF1 IDH1
41 small intestine leiomyoma 9.8 PDGFRA NF1
42 brain glioma 9.8 NF1 KDM4C IDH1
43 cardiovascular organ benign neoplasm 9.8 NF1 KDM4C H2AC18
44 endocrine organ benign neoplasm 9.8 NF1 KDM4C H2AC18
45 childhood pilocytic astrocytoma 9.7 NF1 IDH1 H3-3B H3-3A
46 juvenile pilocytic astrocytoma 9.7 NF1 IDH1 H3-3B H3-3A
47 spinal cancer 9.7 NF1 IDH1 H3-3B H3-3A
48 esophagus leiomyoma 9.7 PDGFRA NF1
49 pilocytic astrocytoma of cerebellum 9.7 NF1 IDH1 H3C11 H3C10
50 cerebellar astrocytoma 9.7 NF1 IDH1 H3C11 H3C10

Graphical network of the top 20 diseases related to Brain Stem Cancer:



Diseases related to Brain Stem Cancer

Symptoms & Phenotypes for Brain Stem Cancer

GenomeRNAi Phenotypes related to Brain Stem Cancer according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 9.55 H2AC18
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.55 H3C1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-122 9.55 H3C4
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.55 H2AC18
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.55 H2AC18
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-168 9.55 H2AC18
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-178 9.55 PPM1D
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-214 9.55 H3C1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.55 H2AC18 H3C4
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-25 9.55 H3C1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.55 H2AC18 H3C4
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-42 9.55 H3C1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-43 9.55 H2AC18
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.55 H3C1
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-81 9.55 H3C4

MGI Mouse Phenotypes related to Brain Stem Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.1 ACVR1 H3C10 KDM4C NF1 PDGFRA PPM1D

Drugs & Therapeutics for Brain Stem Cancer

Drugs for Brain Stem Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
2
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
3
Thalidomide Approved, Investigational, Withdrawn Phase 2 50-35-1 5426
4
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
5
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
6
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
7
Cetuximab Approved Phase 2 205923-56-4 56842117 2333
8
Nimotuzumab Investigational Phase 2 780758-10-3, 828933-61-3
9
Imetelstat Investigational Phase 2 868169-64-6
10 Alkylating Agents Phase 2
11 Angiogenesis Inhibitors Phase 2
12 Immunosuppressive Agents Phase 2
13 Immunologic Factors Phase 2
14 Antineoplastic Agents, Immunological Phase 2
15 topoisomerase I inhibitors Phase 2
16 Protein Kinase Inhibitors Phase 2
17
Motesanib diphosphate Phase 2 850649-62-6 11450633
18
Piperazine Approved, Vet_approved Phase 1 110-85-0 4837
19
Mebendazole Approved, Vet_approved Phase 1 31431-39-7 4030
20
Sodium citrate Approved, Investigational Phase 1 68-04-2
21
Citric acid Approved, Nutraceutical, Vet_approved Phase 1 77-92-9 311
22
Entinostat Investigational Phase 1 209783-80-2
23
Rindopepimut Investigational Phase 1 1108208-65-6
24 Tubulin Modulators Phase 1
25 Citrate Phase 1
26 Antimitotic Agents Phase 1
27 Antiparasitic Agents Phase 1
28 DMP 777 Phase 1 157341-41-8
29 Anthelmintics Phase 1
30 Piperazine citrate Phase 1
31 Histone Deacetylase Inhibitors Phase 1
32 Vaccines Phase 1

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Phase 2 Study of Nimotuzumab in Combination With Radio-chemotherapy for the Treatment of Brainstem Tumor in Children Unknown status NCT02672241 Phase 2 Nimotuzumab;Temozolomide
2 Thalomid and Carboplatin for the Treatment of Pediatric Brain Stem Glioma Completed NCT00179881 Phase 2 Carboplatin;Thalomid
3 A Phase 2 Study of Dasatinib in Combination With Everolimus for Children With Gliomas Harboring PDGFR Alterations Recruiting NCT03352427 Phase 2 Dasatinib;Everolimus
4 A Phase II Study of Anlotinib Combined With Radiation in Patients With Malignant Brainstem Glioma Recruiting NCT04668508 Phase 2 Anlotinib
5 A Phase 2 Study of Oral Selpercatinib (LOXO-292) in Patients With Advanced Solid Tumors, Including Rearranged in Transfection (RET) Fusion-Positive Solid Tumors, Medullary Thyroid Cancer and Other Tumors With RET Activation Active, not recruiting NCT04280081 Phase 2 Selpercatinib
6 A Phase II Trial of External Beam Radiation Therapy and Cetuximab Followed by Irinotecan and Cetuximab for Children and Young Adults With Newly Diagnosed Diffuse Pontine Tumors and High-Grade Astrocytomas (POE08-01) Active, not recruiting NCT01012609 Phase 2
7 A Molecular Biology and Phase II Study of Imetelstat (GRN163L) in Children With Recurrent High-Grade Glioma, Ependymoma and Diffuse Intrinsic Pontine Glioma Terminated NCT01836549 Phase 2 imetelstat sodium
8 A Phase I Trial of p28 (NSC745104), a Non-HDM2 Mediated Peptide Inhibitor of p53 Ubiquitination in Pediatric Patients With Recurrent or Progressive CNS Tumors Completed NCT01975116 Phase 1 azurin-derived cell-penetrating peptide p28
9 Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors Recruiting NCT02644291 Phase 1 Mebendazole
10 A Phase 1 Study of Entinostat, an Oral Histone Deacetylase Inhibitor, in Pediatric Patients With Recurrent or Refractory Solid Tumors, Including CNS Tumors and Lymphoma Active, not recruiting NCT02780804 Phase 1 Entinostat
11 A Phase I Study of Rindopepimut After Conventional Radiation in Children With Diffuse Intrinsic Pontine Gliomas Terminated NCT01058850 Phase 1
12 A Phase I Study of IMC-A12 (Anti-Insulin-like Growth Factor-I Receptor Monoclonal Antibody) in Combination With CCI-779 (Temsirolimus) in Pediatric Patients With Recurrent or Refractory Solid Tumors Withdrawn NCT01182883 Phase 1 IMC-A12;Temsirolimus
13 Vegetative Monitoring During Brainstem-associated Surgery Unknown status NCT03666507
14 The Registry of Oncology Outcomes Associated With Testing and Treatment (ROOT) Not yet recruiting NCT04028479 Systemic Treatment (T)

Search NIH Clinical Center for Brain Stem Cancer

Cochrane evidence based reviews: brain stem neoplasms

Genetic Tests for Brain Stem Cancer

Anatomical Context for Brain Stem Cancer

MalaCards organs/tissues related to Brain Stem Cancer:

40
Brain, Eye, Bone, Spinal Cord, Cerebellum, Small Intestine, Colon

Publications for Brain Stem Cancer

Articles related to Brain Stem Cancer:

# Title Authors PMID Year
1
Ventral surgical approach to the caudal brain stem in dogs. 61
11098786 2000
2
[Radiotherapy for brain stem neoplasms in children]. 61
11219947 2000
3
The long-term outcome after surgical treatment of dorsally exophytic brain-stem gliomas. 61
8487066 1993
4
Surgical management of brain stem tumors of childhood and adolescence. 61
2135963 1990
5
A staging system for brain stem gliomas. 61
4027915 1985
6
[Alteration of the early R1-component of the blink reflex in coma: topographical and prognostic value (author's transl)]. 61
6773736 1980
7
Brain stem auditory evoked potentials in determining site of lesion of brain stem gliomas in children. 61
7354694 1980
8
Orthostatic hypotension following surgery on brain-stem neoplasms: report of two cases. 61
4414953 1974

Variations for Brain Stem Cancer

Expression for Brain Stem Cancer

Search GEO for disease gene expression data for Brain Stem Cancer.

Pathways for Brain Stem Cancer

Pathways related to Brain Stem Cancer according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.22 PDGFRA NF1 KDM4C H3C8 H3C7 H3C6
2
Show member pathways
14.04 PDGFRA NF1 IDH1 H3C8 H3C7 H3C6
3
Show member pathways
13.92 KDM6B KDM4C H3C8 H3C7 H3C6 H3C4
4
Show member pathways
13.91 PDGFRA NF1 H3C8 H3C7 H3C6 H3C4
5
Show member pathways
13.9 PDGFRA H3C8 H3C7 H3C6 H3C4 H3C3
6
Show member pathways
13.87 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
7
Show member pathways
13.86 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
8
Show member pathways
13.67 PDGFRA H3C8 H3C7 H3C6 H3C4 H3C3
9
Show member pathways
13.65 PDGFRA H3C8 H3C7 H3C6 H3C4 H3C3
10
Show member pathways
13.62 PDGFRA NF1 H3C8 H3C7 H3C6 H3C4
11
Show member pathways
13.53 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
12
Show member pathways
13.47 PDGFRA NF1 H3C8 H3C7 H3C6 H3C4
13
Show member pathways
13.43 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
14
Show member pathways
13.3 KDM6B H3C8 H3C7 H3C6 H3C4 H3C3
15
Show member pathways
13.19 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
16
Show member pathways
13.18 KDM6B KDM4C H3C8 H3C7 H3C6 H3C4
17
Show member pathways
12.83 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
18 12.6 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
19
Show member pathways
12.59 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
20 12.52 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
21
Show member pathways
12.37 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
22
Show member pathways
12.33 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
23
Show member pathways
12.33 KDM4C H3C8 H3C7 H3C6 H3C4 H3C3
24 12.3 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
25
Show member pathways
12.23 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
26 12.11 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
27 11.64 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2

GO Terms for Brain Stem Cancer

Cellular components related to Brain Stem Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.36 PPM1D PDGFRA NF1 KDM6B KDM4C H3C8
2 nucleoplasm GO:0005654 10.27 PPM1D PDGFRA KDM6B KDM4C H3C8 H3C7
3 extracellular region GO:0005576 10.25 IDH1 H3C8 H3C7 H3C6 H3C4 H3C3
4 extracellular exosome GO:0070062 10.17 IDH1 H3C8 H3C7 H3C6 H3C4 H3C3
5 protein-containing complex GO:0032991 10.07 PDGFRA H3C8 H3C7 H3C6 H3C4 H3C3
6 nuclear chromosome GO:0000228 9.93 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
7 chromosome GO:0005694 9.77 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
8 Barr body GO:0001740 9.46 H3-3B H3-3A
9 nucleosome GO:0000786 9.44 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2

Biological processes related to Brain Stem Cancer according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 regulation of gene silencing by miRNA GO:0060964 10.23 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
2 regulation of gene silencing GO:0060968 10.21 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
3 regulation of megakaryocyte differentiation GO:0045652 10.21 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
4 interleukin-7-mediated signaling pathway GO:0038111 10.19 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
5 DNA replication-dependent nucleosome assembly GO:0006335 10.18 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
6 cellular protein metabolic process GO:0044267 10.18 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
7 telomere organization GO:0032200 10.15 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
8 blood coagulation GO:0007596 10.1 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
9 nucleosome assembly GO:0006334 10.03 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
10 chromatin organization GO:0006325 9.93 KDM6B KDM4C H3C8 H3C7 H3C6 H3C4
11 osteoblast differentiation GO:0001649 9.74 NF1 H3-3B H3-3A
12 chromatin silencing at rDNA GO:0000183 9.73 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
13 adrenal gland development GO:0030325 9.58 PDGFRA NF1
14 muscle cell differentiation GO:0042692 9.58 H3-3B H3-3A
15 pericentric heterochromatin assembly GO:0031508 9.56 H3-3B H3-3A
16 regulation of centromere complex assembly GO:0090230 9.55 H3-3B H3-3A
17 negative regulation of chromosome condensation GO:1902340 9.54 H3-3B H3-3A
18 telomeric heterochromatin assembly GO:0031509 9.52 H3-3B H3-3A
19 negative regulation of gene expression, epigenetic GO:0045814 9.44 PPM1D H3C8 H3C7 H3C6 H3C4 H3C3

Molecular functions related to Brain Stem Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.23 PPM1D PDGFRA NF1 KDM6B IDH1 H3C8
2 DNA binding GO:0003677 9.97 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
3 cadherin binding GO:0045296 9.73 IDH1 H3C8 H3C7 H3C6 H3C4 H3C3
4 protein heterodimerization activity GO:0046982 9.44 H3C8 H3C7 H3C6 H3C4 H3C3 H3C2
5 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.32 H3-3B H3-3A

Sources for Brain Stem Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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