MCID: BRN048
MIFTS: 37

Brain Stem Cancer

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Brain Stem Cancer

MalaCards integrated aliases for Brain Stem Cancer:

Name: Brain Stem Cancer 12 53 15
Brain Stem Neoplasms 44 73
Malignant Neoplasm of Brain Stem 12
Malignant Neoplasm of Brainstem 12
Brain Stem Neoplasms, Primary 73
Malignant Tumor of Brainstem 12
Neoplasm of Adult Brain Stem 12
Primary Brain Stem Neoplasm 12
Primary Brain Stem Tumor 12
Tumor of Adult Brainstem 12
Neoplasm of Brain Stem 12
Tumor of the Brainstem 12
Brain Stem--Cancer 73
Brain Stem Tumors 55

Classifications:



External Ids:

Disease Ontology 12 DOID:4203
ICD10 33 C71.7
ICD9CM 35 191.7
MeSH 44 D020295
SNOMED-CT 68 93726004

Summaries for Brain Stem Cancer

MalaCards based summary : Brain Stem Cancer, also known as brain stem neoplasms, is related to brain stem glioma and fibrillary astrocytoma. An important gene associated with Brain Stem Cancer is NES (Nestin), and among its related pathways/superpathways are TGF-Beta Pathway and Response to elevated platelet cytosolic Ca2+. Affiliated tissues include brain, spinal cord and bone.

Wikipedia : 76 A brain stem tumor is a tumor in the part of the brain that connects to the spinal cord (the brain... more...

Related Diseases for Brain Stem Cancer

Diseases related to Brain Stem Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 brain stem glioma 30.4 BSG H3F3A H3F3B HIST1H3B PDGFB TMPRSS11D
2 fibrillary astrocytoma 29.6 H3F3A TP53
3 brain stem medulloblastoma 11.0
4 cerebellopontine angle tumor 11.0
5 childhood infratentorial neoplasm 11.0
6 adult brain stem glioma 11.0
7 brain stem angioblastoma 11.0
8 central nervous system primitive neuroectodermal neoplasm 10.1 NES TP53
9 ependymoblastoma 10.1 NES TP53
10 gliomatosis cerebri 10.1 NES TP53
11 glioma susceptibility 1 10.1 H3F3A TP53
12 adult astrocytic tumour 10.1 H3F3A H3F3B
13 benign glioma 10.0 H3F3A TP53
14 optic nerve neoplasm 10.0 NES TP53
15 cerebral primitive neuroectodermal tumor 10.0 BSG TP53
16 brain glioma 10.0 NES TP53
17 chondroblastoma 10.0 H3F3A H3F3B
18 optic nerve glioma 10.0 NES TP53
19 infratentorial cancer 10.0 NES TP53
20 ganglioglioma 10.0 H3F3A NES TP53
21 diffuse intrinsic pontine glioma 9.9 H3F3A H3F3B HIST1H3B
22 bone giant cell sarcoma 9.9 H3F3A H3F3B TP53
23 malignant giant cell tumor 9.9 H3F3A H3F3B TP53
24 dermatofibrosarcoma protuberans 9.9 NES PDGFB TP53
25 grade iii astrocytoma 9.9 BSG TP53
26 glioma 9.9 H3F3A PDGFB TP53
27 astrocytoma 9.8
28 glioblastoma multiforme 9.8 NES PDGFB TP53
29 connective tissue cancer 9.8 PDGFB TP53
30 chiari malformation 9.8
31 supratentorial cancer 9.8 H3F3A H3F3B NES TP53
32 cerebrum cancer 9.8 H3F3A H3F3B NES TP53
33 central nervous system cancer 9.8 H3F3A H3F3B NES TP53
34 spinal cord astrocytoma 9.8 BSG H3F3A H3F3B TP53
35 brain cancer 9.7 NES PDGFB TP53
36 dysembryoplastic neuroepithelial tumor 9.7
37 heparin-induced thrombocytopenia 9.7
38 papilloma of choroid plexus 9.7
39 papilloma 9.7
40 pilocytic astrocytoma 9.7
41 hemifacial spasm 9.7
42 medulloblastoma 9.6 NES PDGFB PPM1D TP53

Graphical network of the top 20 diseases related to Brain Stem Cancer:



Diseases related to Brain Stem Cancer

Symptoms & Phenotypes for Brain Stem Cancer

Drugs & Therapeutics for Brain Stem Cancer

Search Clinical Trials , NIH Clinical Center for Brain Stem Cancer

Cochrane evidence based reviews: brain stem neoplasms

Genetic Tests for Brain Stem Cancer

Anatomical Context for Brain Stem Cancer

MalaCards organs/tissues related to Brain Stem Cancer:

41
Brain, Spinal Cord, Bone, Thyroid

Publications for Brain Stem Cancer

Articles related to Brain Stem Cancer:

# Title Authors Year
1
Orthostatic hypotension following surgery on brain-stem neoplasms: report of two cases. ( 4414953 )
1974

Variations for Brain Stem Cancer

Expression for Brain Stem Cancer

Search GEO for disease gene expression data for Brain Stem Cancer.

Pathways for Brain Stem Cancer

Pathways related to Brain Stem Cancer according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.13 H3F3A H3F3B HIST1H3B PDGFB TP53
2
Show member pathways
12.88 BSG H3F3A H3F3B HIST1H3B PDGFB TP53
3
Show member pathways
12.76 H3F3A H3F3B HIST1H3B TP53
4
Show member pathways
12.12 H3F3A H3F3B HIST1H3B
5
Show member pathways
11.96 H3F3A H3F3B TP53
6
Show member pathways
11.89 H3F3A H3F3B HIST1H3B
7 11.83 H3F3A H3F3B HIST1H3B TP53
8
Show member pathways
11.7 H3F3A H3F3B HIST1H3B
9 11.65 H3F3A H3F3B HIST1H3B TP53
10
Show member pathways
11.35 H3F3A H3F3B HIST1H3B TP53
11 11.29 PPM1D TP53
12 10.98 H3F3A H3F3B
13 10.34 H3F3A H3F3B HIST1H3B TP53

GO Terms for Brain Stem Cancer

Cellular components related to Brain Stem Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.62 H3F3A H3F3B HIST1H3B TP53
2 nucleosome GO:0000786 9.43 H3F3A H3F3B HIST1H3B
3 Barr body GO:0001740 9.16 H3F3A H3F3B
4 nuclear chromosome GO:0000228 9.13 H3F3A H3F3B HIST1H3B
5 nuclear nucleosome GO:0000788 8.8 H3F3A H3F3B HIST1H3B

Biological processes related to Brain Stem Cancer according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 brain development GO:0007420 9.77 H3F3A H3F3B NES
2 cellular protein metabolic process GO:0044267 9.76 H3F3A H3F3B HIST1H3B
3 blood coagulation GO:0007596 9.71 H3F3A H3F3B HIST1H3B
4 nucleosome assembly GO:0006334 9.67 H3F3A H3F3B HIST1H3B
5 regulation of megakaryocyte differentiation GO:0045652 9.65 H3F3A H3F3B HIST1H3B
6 response to hormone GO:0009725 9.61 H3F3A H3F3B
7 regulation of gene silencing by miRNA GO:0060964 9.61 H3F3A H3F3B HIST1H3B
8 oogenesis GO:0048477 9.59 H3F3A H3F3B
9 nucleus organization GO:0006997 9.58 H3F3A H3F3B
10 positive regulation of reactive oxygen species metabolic process GO:2000379 9.57 PDGFB TP53
11 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.56 PDGFB TP53
12 DNA replication-independent nucleosome assembly GO:0006336 9.55 H3F3A H3F3B
13 embryo implantation GO:0007566 9.54 BSG H3F3A H3F3B
14 muscle cell differentiation GO:0042692 9.52 H3F3A H3F3B
15 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.51 PPM1D TP53
16 chromatin silencing at rDNA GO:0000183 9.5 H3F3A H3F3B HIST1H3B
17 pericentric heterochromatin assembly GO:0031508 9.46 H3F3A H3F3B
18 regulation of centromere complex assembly GO:0090230 9.4 H3F3A H3F3B
19 negative regulation of chromosome condensation GO:1902340 9.26 H3F3A H3F3B
20 telomeric heterochromatin assembly GO:0031509 9.16 H3F3A H3F3B
21 telomere organization GO:0032200 9.13 H3F3A H3F3B HIST1H3B
22 negative regulation of gene expression, epigenetic GO:0045814 8.92 H3F3A H3F3B HIST1H3B PPM1D

Molecular functions related to Brain Stem Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.33 H3F3A H3F3B TP53
2 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.26 H3F3A H3F3B
3 nucleosomal DNA binding GO:0031492 9.13 H3F3A H3F3B HIST1H3B
4 protein heterodimerization activity GO:0046982 9.02 H3F3A H3F3B HIST1H3B PDGFB TP53

Sources for Brain Stem Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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