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MCID: BRN036
MIFTS: 38

Brain Stem Infarction

Categories: Cardiovascular diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Brain Stem Infarction

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MalaCards integrated aliases for Brain Stem Infarction:

Name: Brain Stem Infarction 12 15 17
Brain Stem Infarctions 43 71
Brainstem Infarction 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3523
MeSH 43 D020526
SNOMED-CT 67 95457000
UMLS 71 C0521542
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Summaries for Brain Stem Infarction

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Disease Ontology : 12 A brain infarction that is characterized by stroke of the brain stem that develops from blockage or narrowing in the arteries located in the brainstem, has material basis in damage to the cranial nerve nuclei and long tracts, has symptom vertigo, has symptom imbalance, has symptom decreased level of arousal.

MalaCards based summary : Brain Stem Infarction, also known as brain stem infarctions, is related to vertebral artery occlusion and basilar artery occlusion, and has symptoms including vertigo, imbalance and decreased level of arousal. An important gene associated with Brain Stem Infarction is LDB1 (LIM Domain Binding 1), and among its related pathways/superpathways are Cell adhesion_Plasmin signaling and amb2 Integrin signaling. The drugs Clotrimazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include brainstem, brain and eye, and related phenotypes are craniofacial and hematopoietic system

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Related Diseases for Brain Stem Infarction

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Diseases related to Brain Stem Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 vertebral artery occlusion 30.7 PLG PLAT
2 basilar artery occlusion 30.3 TSPAN33 PLG PLAT
3 facial paralysis 29.9 PLAT CRLF1
4 obstructive hydrocephalus 29.8 PLG PLAT CRLF1
5 lateral medullary syndrome 11.6
6 ligneous conjunctivitis 10.4 PLG PLAT
7 anterior cerebral artery infarction 10.4 PLG PLAT
8 basilar artery insufficiency 10.4 TSPAN33 PLG
9 basal ganglia cerebrovascular disease 10.4 PLG PLAT
10 acute cor pulmonale 10.4 PLG PLAT
11 acute pulmonary heart disease 10.4 PLG PLAT
12 marantic endocarditis 10.4 PLG PLAT
13 thoracic outlet syndrome 10.4 PLG PLAT
14 inferior myocardial infarction 10.3 PLG PLAT
15 intracranial sinus thrombosis 10.3 TSPAN33 PLG
16 cerebral falx meningioma 10.3 PLG PLAT
17 conversion disorder 10.3 PLG PLAT
18 hereditary angioedema with normal c1inh 10.3 PLG PLAT
19 sagittal sinus thrombosis 10.3 TSPAN33 PLG
20 middle cerebral artery infarction 10.3 PLG PLAT
21 central retinal artery occlusion 10.3 PLG PLAT
22 encephalopathy, familial, with neuroserpin inclusion bodies 10.3 PLG PLAT
23 post-thrombotic syndrome 10.3 PLG PLAT
24 cardiac tamponade 10.3 PLG PLAT
25 plexopathy 10.3 LDB1 HECTD4
26 intracranial thrombosis 10.3 PLG PLAT
27 thrombophilia due to activated protein c resistance 10.3 PLG PLAT
28 facial neuralgia 10.2 SPAG11B CRLF1
29 cerebral artery occlusion 10.2 TSPAN33 PLG
30 thrombophlebitis 10.2 PLG PLAT
31 central retinal vein occlusion 10.2 PLG PLAT
32 coronary thrombosis 10.2 PLG PLAT
33 compartment syndrome 10.2 PLG HECTD4
34 intracranial embolism 10.2 TSPAN33 PLG PLAT
35 mutism 10.2
36 posterior cerebral artery infarction 10.2 TSPAN33 PLG PLAT
37 occlusion precerebral artery 10.2 TSPAN33 PLG PLAT
38 carotid artery occlusion 10.2 TSPAN33 PLG PLAT
39 intermediate coronary syndrome 10.1 PLG PLAT
40 pulmonary artery disease 10.1 PLG PLAT
41 ocular motor apraxia 10.1
42 dysphagia 10.1
43 facial nerve disease 10.1 PLG PLAT CRLF1
44 speech and communication disorders 10.0 PLG PLAT HECTD4
45 alternating exotropia 10.0
46 exotropia 10.0
47 bacterial meningitis 10.0
48 cerebral arterial disease 10.0 TSPAN33 PLG
49 motion sickness 10.0 PCSK5 CMTR2
50 ataxia and polyneuropathy, adult-onset 9.9

Graphical network of the top 20 diseases related to Brain Stem Infarction:



Diseases related to Brain Stem Infarction
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Symptoms & Phenotypes for Brain Stem Infarction

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Symptoms:

12
  • • vertigo
  • • imbalance
  • • decreased level of arousal

MGI Mouse Phenotypes related to Brain Stem Infarction:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.43 LDB1 LZTR1 PCSK5 PLAT SLC6A5 ZMIZ1
2 hematopoietic system MP:0005397 9.28 CRLF1 LDB1 LZTR1 PCSK5 PLAT PLG
Sources

Drugs & Therapeutics for Brain Stem Infarction

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Drugs for Brain Stem Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clotrimazole Approved, Vet_approved Phase 2, Phase 3 23593-75-1 2812
2
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
3
Sirolimus Approved, Investigational Phase 2, Phase 3 53123-88-9 5284616 6436030 46835353
4 Anti-Infective Agents Phase 2, Phase 3
5 Antifungal Agents Phase 2, Phase 3
6 Anti-Bacterial Agents Phase 2, Phase 3
7 Antibiotics, Antitubercular Phase 2, Phase 3
8 Anticonvulsants Phase 1, Phase 2
9 Epidiolex Phase 1, Phase 2
10
Timolol Approved Phase 1 26839-75-8 5478 33624
11
Maleic acid Experimental, Investigational Phase 1 110-17-8, 110-16-7 444972
12 Pharmaceutical Solutions Phase 1
13 Adrenergic beta-Antagonists Phase 1
14 Antihypertensive Agents Phase 1
15 Adrenergic Agents Phase 1
16 Adrenergic Antagonists Phase 1
17 Anti-Arrhythmia Agents Phase 1
18 Lubricant Eye Drops Phase 1
19 Neurotransmitter Agents Phase 1
20 Ophthalmic Solutions Phase 1
21 GTPase-Activating Proteins
22 Antibodies
23 Immunoglobulins

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Trial of Sirolimus for Cognitive Impairment in Sturge-Weber Syndrome Active, not recruiting NCT03047980 Phase 2, Phase 3 Sirolimus
2 Phase II, Randomized, Triple Blind, Intra-individually Placebo-controlled Clinical Trial to Assess the Efficacy and Safety of Topical Rapamycin Associated With Pulsed Dye Laser in Patients With Sturge-Weber Syndrome. Completed NCT02080624 Phase 2 Drug: Topical Rapamycin
3 Cannabidiol Expanded Access Study in Medically Refractory Sturge-Weber Syndrome Active, not recruiting NCT02332655 Phase 1, Phase 2 Cannabidiol
4 An Open-Label Controlled Study of Adjunctive Everolimus (RAD 001) Therapy for Epilepsy in Children With Sturge-Weber Syndrome Withdrawn NCT01997255 Phase 2 Everolimus
5 Use of the Atkins Diet for Children With Sturge Weber Syndrome Completed NCT00639730 Phase 1
6 Treatment of Port-wine Mark in Sturge-Weber Syndrome Using Topical Timolol Terminated NCT01533376 Phase 1 Timolol;Preservative free artificial tear gel.
7 French National Prospective Cohort of Children With Port Wine Stain on a Limb = "Cohorte Nationale d'Enfants Avec Angiome Plan de Membre inférieur" Unknown status NCT01364857
8 Establishing Reliability for Quantitative EEG, Transcranial Doppler, Behavioral Outcomes and Optical Coherence Tomography in SWS: The Next Step Toward Biomarker Development Completed NCT01345305
9 Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS) Completed NCT00610402
10 Acute Electrocorticography (ECoG) Direct Brain Interface for Individuals With Upper Limb Paralysis Completed NCT01393444
11 BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia Recruiting NCT00912041
12 A Sensorimotor Microelectrode Brain-Machine Interface for Individuals With Tetraplegia Recruiting NCT01894802
13 Investigation on the Cortical Communication (CortiCom) System Recruiting NCT03567213
14 Real World Testing of a Brain-Computer Interface to Operate a Commercial Augmentative and Alternative Communication System Recruiting NCT04026581
15 Use of a Tonometer to Identify Focal Cortical Dysplasia and Tuberous Sclerosis Complex During Pediatric Epilepsy Surgery Recruiting NCT04344626
16 The Brain Vascular Malformations Clinical Research Network: Predictors of Clinical Course, Project 2: Innovative Approaches to Gauge Progression of Sturge-Weber Syndrome Active, not recruiting NCT01425944
17 Transcranial Direct Current Stimulation (tDCS) for Patients With Oro-pharyngeal Dysphagia Associated to Brainstem Stroke Not yet recruiting NCT04308733

Search NIH Clinical Center for Brain Stem Infarction

Cochrane evidence based reviews: brain stem infarctions

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Genetic Tests for Brain Stem Infarction

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Anatomical Context for Brain Stem Infarction

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The Foundational Model of Anatomy Ontology organs/tissues related to Brain Stem Infarction:

19
Brainstem

MalaCards organs/tissues related to Brain Stem Infarction:

40
Brain, Eye, Testes, Cerebellum, Cortex, Spinal Cord, Heart
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Publications for Brain Stem Infarction

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Articles related to Brain Stem Infarction:

(show top 50) (show all 233)
# Title Authors PMID Year
1
Association of pretreatment pontine infarction with extremely poor outcome after endovascular thrombectomy in acute basilar artery occlusion. 61
32447299 2020
2
Endoscopic surgical treatment of Cushing's disease: A single-center experience of cauterization of peritumoral tissues. 61
31777545 2019
3
[Catheter balloon dilation combined with acupuncture for cricopharyngeal achalasia after brain stem infarction: a randomized controlled trial]. 61
31621251 2019
4
Experience in Rehabilitation Medicine Affects Prognosis and End-of-Life Decision-Making of Neurologists: A Case-Based Survey. 61
30607828 2019
5
Brain stem infarction in a 6-year-old boy with Down syndrome. 61
30857880 2019
6
Unnecessary Cervical Epidural Injection in An Octogenarian. 61
31528446 2019
7
Spinal Cord Infarction in the Region of the Posterior Spinal Artery After Embolization for Vertebral Artery Dissection. 61
29538687 2018
8
A cohort study of isolated brainstem infarction based on head MR imaging and clinical findings. 61
30246581 2018
9
Brainstem infarction associated with HHV-6 infection in an infant. 61
28958731 2018
10
Delayed Infarction of Medullar and Cerebellum 3 Months after Vertebral Artery Injury with C1-2 Fracture: Case Report. 61
28512615 2017
11
Preventive Suboccipital Decompressive Craniectomy for Cerebellar Infarction: A Retrospective-Matched Case-Control Study. 61
27608818 2016
12
[Brain stem infarction, temporal headache, and elevated inflammatory parameters in a 74-year-old man]. 61
27055655 2016
13
Herpetic cranial polyneuritis mimicking brain stem infarction-an atypical presentation of Ramsay Hunt syndrome. 61
27251418 2016
14
Brain Stem Infarction Due to Basilar Artery Dissection in a Patient with Moyamoya Disease Four Years after Successful Bilateral Revascularization Surgeries. 61
27068774 2016
15
Microstructural abnormalities of the trigeminal nerve by diffusion-tensor imaging in trigeminal neuralgia without neurovascular compression. 61
26678753 2016
16
Ruptured Pseudoaneurysm after Gamma Knife Surgery for Vestibular Schwannoma. 61
26667081 2016
17
Severe White Matter Hyperintensity Is Associated with Early Neurological Deterioration in Patients with Isolated Pontine Infarction. 61
27532619 2016
18
Erectile dysfunction (ED) after ischemic stroke: association between prevalence and site of lesion. 61
26374302 2015
19
Acute pontine infarction after percutaneous coronary intervention: a very rare but devastating complication. 61
26037684 2015
20
Molecular hydrogen in sports medicine: new therapeutic perspectives. 61
25525953 2015
21
[Hybrid treatment of aortic arch disease with ascending aorta to carotid artery revascularization and subsequent endovascular repair]. 61
25908289 2015
22
Evaluation of the pontine perforators of the basilar artery using digital subtraction angiography in high resolution and 3D rotation technique. 61
24904054 2014
23
"Invisible" brain stem infarction at the first day. 61
24809672 2014
24
Sudden unexpected death owing to unilateral medial medullary infarction with early involvement of the respiratory center. 61
24508471 2014
25
Posterior circulation hyperperfusion syndrome after superficial temporal artery-superior cerebellar artery bypass for vertebral artery dissection. 61
23721618 2014
26
[Cervical cord infarction associated with unilateral vertebral artery dissection due to golf swing]. 61
24583591 2014
27
Bilateral cerebellar and brain stem infarction resulting from vertebral artery injury following cervical trauma without radiographic damage of the spinal column: a case report. 61
24061492 2014
28
Isolated third, fourth, and sixth cranial nerve palsies from presumed microvascular versus other causes: a prospective study. 61
23747163 2013
29
[Long-term results of open stent-grafting applied with a Matsui-Kitamura( MK) stent in treatment of arch aneurysm]. 61
24105114 2013
30
A case of peduncular hallucinosis presenting as a primary psychiatric disorder. 61
24339609 2013
31
Brain stem infarction associated with familial Mediterranean fever and central nervous system vasculitis. 61
23710607 2013
32
Giant aneurysm of the basilar artery in an 86 year old woman. 61
24358886 2013
33
[Conversion of a retrograde access to an antegrade access for bilateral femorocrural intervention in one session]. 61
22549552 2012
34
Waffle-Cone Technique Using Solitaire AB Stent. 61
22737303 2012
35
Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. 61
22720117 2012
36
[Dysphagia in Avellis' syndrome]. 61
22373552 2012
37
Should intentional endovascular stent-graft coverage of the left subclavian artery be preceded by prophylactic revascularisation? 61
21376612 2011
38
Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. 61
22146674 2011
39
Fatal outcome after brain stem infarction related to bilateral vertebral artery occlusion - case report of a detrimental complication of cervical spine trauma. 61
21756312 2011
40
Early single center experience with the solitaire thrombectomy device for the treatment of acute ischemic stroke. 61
21696665 2011
41
[An evaluation of clinical characteristics and prognosis of brain-stem infarction in diabetics]. 61
21418884 2011
42
Spontaneous regression of an anterior skull base mass. 61
20356749 2010
43
Hybrid treatment of aberrant right subclavian artery and its aneurysms. 61
20690521 2010
44
Endovascular management of vertebral artery dissecting aneurysms: review of 25 patients. 61
20401839 2010
45
Simultaneous unilateral internal carotid artery and occlusive basilar artery dissections. 61
20121537 2010
46
Clinical presentation of intracranial epidermoids: a surgical series of 20 initial and four recurred cases. 61
22028741 2010
47
Surgical treatment of intracranial VA dissecting aneurysm. 61
19953371 2010
48
Successful treatment of pulmonary aspiration due to brain stem infarction by using cough exercise based on swallowing scintigraphy: preliminary observations. 61
19387737 2009
49
[A case of brainstem variant of reversible posterior leukoencephalopathy syndrome]. 61
19938667 2009
50
Contrast extravasation after bilateral inferior petrosal sinus sampling masquerading as venous subarachnoid haemorrhage. 61
19960150 2009
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Variations for Brain Stem Infarction

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Expression for Brain Stem Infarction

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Search GEO for disease gene expression data for Brain Stem Infarction.
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Pathways for Brain Stem Infarction

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Pathways related to Brain Stem Infarction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cell adhesion_Plasmin signaling 22
10.95 PLG PLAT
2
amb2 Integrin signaling 1
10.84 PLG PLAT
3
A-beta Plaque Formation and APP Metabolism 64
10.32 PLG PLAT
4
Dissolution of Fibrin Clot 65
9.74 PLG PLAT
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GO Terms for Brain Stem Infarction

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Cellular components related to Brain Stem Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.92 TSPAN33 PLG PLAT CPM

Biological processes related to Brain Stem Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.46 PLG PLAT PCSK5 CPM
2 fibrinolysis GO:0042730 8.96 PLG PLAT
3 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 8.62 PLG PLAT

Molecular functions related to Brain Stem Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.46 PLG PLAT PCSK5 CPM
2 serine-type endopeptidase activity GO:0004252 9.13 PLG PLAT PCSK5
3 serine-type peptidase activity GO:0008236 8.8 PLG PLAT PCSK5
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Sources for Brain Stem Infarction

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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