MCID: BRN036
MIFTS: 32

Brain Stem Infarction

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Brain Stem Infarction

MalaCards integrated aliases for Brain Stem Infarction:

Name: Brain Stem Infarction 12 15
Brain Stem Infarctions 44 73
Brainstem Infarction 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3523
MeSH 44 D020526
SNOMED-CT 68 95457000
UMLS 73 C0521542

Summaries for Brain Stem Infarction

Disease Ontology : 12 A brain infarction that is characterized by stroke of the brain stem that develops from blockage or narrowing in the arteries located in the brainstem, has material basis in damage to the cranial nerve nuclei and long tracts, has symptom vertigo, has symptom imbalance, has symptom decreased level of arousal.

MalaCards based summary : Brain Stem Infarction, also known as brain stem infarctions, is related to lateral medullary syndrome and basilar artery occlusion, and has symptoms including vertigo, imbalance and decreased level of arousal. An important gene associated with Brain Stem Infarction is FGB (Fibrinogen Beta Chain), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Miconazole and Sirolimus have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and liver.

Related Diseases for Brain Stem Infarction

Graphical network of the top 20 diseases related to Brain Stem Infarction:



Diseases related to Brain Stem Infarction

Symptoms & Phenotypes for Brain Stem Infarction

Symptoms:

12
  • vertigo
  • imbalance
  • decreased level of arousal

Drugs & Therapeutics for Brain Stem Infarction

Drugs for Brain Stem Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
2
Sirolimus Approved, Investigational Phase 2, Phase 3 53123-88-9 46835353 6436030 5284616
3
Everolimus Approved Phase 2, Phase 3 159351-69-6 6442177
4 Anti-Infective Agents Phase 2, Phase 3
5 Immunologic Factors Phase 2, Phase 3
6 Antibiotics, Antitubercular Phase 2, Phase 3
7 Antifungal Agents Phase 2, Phase 3
8 Anti-Bacterial Agents Phase 2, Phase 3
9 Immunosuppressive Agents Phase 2, Phase 3
10 Pharmaceutical Solutions Phase 2, Phase 3,Phase 1
11 Anticonvulsants Phase 1, Phase 2
12
Timolol Approved Phase 1 26839-75-8 33624 5478
13
Maleic acid Experimental Phase 1 110-16-7 444266
14 Anti-Arrhythmia Agents Phase 1
15 Adrenergic beta-Antagonists Phase 1
16 Adrenergic Agents Phase 1
17 Neurotransmitter Agents Phase 1
18 Ophthalmic Solutions Phase 1
19 Antihypertensive Agents Phase 1
20 Adrenergic Antagonists Phase 1
21 Lubricant Eye Drops Phase 1
22 Immunoglobulins
23 Antibodies
24 GTPase-Activating Proteins Not Applicable

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Trial of Sirolimus for Cognitive Impairment in Sturge-Weber Syndrome Recruiting NCT03047980 Phase 2, Phase 3 Sirolimus
2 Efficacy and Safety Study of Topical Rapamycin Associated With Pulsed Dye Laser in Patients With Sturge-Weber Syndrome Completed NCT02080624 Phase 2 Drug: Topical Rapamycin
3 Cannabidiol Expanded Access Study in Medically Refractory Sturge-Weber Syndrome Active, not recruiting NCT02332655 Phase 1, Phase 2 Cannabidiol
4 Adjunctive Everolimus (RAD 001) Therapy for Epilepsy in Children With Sturge-Weber Syndrome (SWS) Withdrawn NCT01997255 Phase 2 Everolimus
5 Use of the Atkins Diet for Children With Sturge Weber Syndrome Completed NCT00639730 Phase 1
6 Treatment of Port-wine Mark in Sturge-Weber Syndrome Using Topical Timolol Recruiting NCT01533376 Phase 1 Timolol;Preservative free artificial tear gel.
7 ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis Completed NCT01393444 Not Applicable
8 Transcranial Direct Current Stimulation for Dysphagia Therapy in Acute Stroke Patients Completed NCT01970384 Not Applicable
9 Biomarker Development in Sturge-Weber Syndrome Completed NCT01345305
10 Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS) Completed NCT00610402
11 Cortical Recording and Stimulating Array Brain-Machine Interface Recruiting NCT01894802 Not Applicable
12 Investigation on the Cortical Communication (CortiCom) System Recruiting NCT03567213 Not Applicable
13 BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia Recruiting NCT00912041 Not Applicable
14 Innovative Approaches to Gauge Progression of Sturge-Weber Syndrome Recruiting NCT01425944
15 French National Cohort of Children With Port Wine Stain Active, not recruiting NCT01364857 Not Applicable
16 NeuroCognitive Communicator: Safety Study Not yet recruiting NCT03100110 Not Applicable

Search NIH Clinical Center for Brain Stem Infarction

Cochrane evidence based reviews: brain stem infarctions

Genetic Tests for Brain Stem Infarction

Anatomical Context for Brain Stem Infarction

MalaCards organs/tissues related to Brain Stem Infarction:

41
Brain, Cerebellum, Liver

The Foundational Model of Anatomy Ontology organs/tissues related to Brain Stem Infarction:

19
The Brainstem

Publications for Brain Stem Infarction

Articles related to Brain Stem Infarction:

(show all 44)
# Title Authors Year
1
Herpetic cranial polyneuritis mimicking brain stem infarction-an atypical presentation of Ramsay Hunt syndrome. ( 27251418 )
2016
2
Brain Stem Infarction Due to Basilar Artery Dissection in a Patient with Moyamoya Disease Four Years after Successful Bilateral Revascularization Surgeries. ( 27068774 )
2016
3
Bilateral cerebellar and brain stem infarction resulting from vertebral artery injury following cervical trauma without radiographic damage of the spinal column: a case report. ( 24061492 )
2014
4
"Invisible" brain stem infarction at the first day. ( 24809672 )
2014
5
Brain stem infarction associated with familial Mediterranean fever and central nervous system vasculitis. ( 23710607 )
2013
6
Fatal outcome after brain stem infarction related to bilateral vertebral artery occlusion - case report of a detrimental complication of cervical spine trauma. ( 21756312 )
2011
7
Partial third nerve palsy involving the superior rectus and levator palpebrae muscles and distruption of central binocular vision fusion from brain stem infarction: a case report. ( 19807689 )
2009
8
Successful treatment of pulmonary aspiration due to brain stem infarction by using cough exercise based on swallowing scintigraphy: preliminary observations. ( 19387737 )
2009
9
Brain stem infarction caused by proximal internal carotid artery stenosis in a patient with a persisting primitive trigeminal artery. ( 16766871 )
2006
10
Brain stem infarction: a complication of microvascular decompression for trigeminal neuralgia. ( 16936412 )
2006
11
Re: Poor surgical technique in cervical plating leading to vertebral artery injury and brain stem infarction--case report (Cho KH, Shin YS, Yoon SH, et al, Surg Neurol 2005;64:221-5). ( 16488269 )
2006
12
Poor surgical technique in cervical plating leading to vertebral artery injury and brain stem infarction--case report. ( 16099249 )
2005
13
Electro-acupuncture for treatment of dysequillibrium due to cerebellum or brain stem infarction. ( 14719296 )
2003
14
Vertebrobasilar artery dissection presenting with simultaneous subarachnoid hemorrhage and brain stem infarction: case report. ( 12633950 )
2003
15
Time course of lesion development in patients with acute brain stem infarction and correlation with NIHSS score. ( 11566246 )
2001
16
Transient mutism after brain stem infarction. ( 10809658 )
2000
17
Natural course of combined limb and palatal tremor caused by cerebellar-brain stem infarction. ( 10495051 )
1999
18
Transient mutism after brain stem infarction. ( 10610613 )
1999
19
Transient mutism after brain stem infarction. ( 10481795 )
1999
20
Transient mutism resolving into cerebellar speech after brain stem infarction following a traumatic injury of the vertebral artery in a child. ( 10189505 )
1999
21
Xenon contrast-enhanced CT imaging of supratentorial hypoperfusion in patients with brain stem infarction. ( 10588109 )
1999
22
Transient mutism after brain stem infarction. ( 10672311 )
1999
23
Transient mutism after brain stem infarction (ref. Acta Neurochirurgia 1999, 141: 209-213) ( 10536732 )
1999
24
The protective effect of a persistent trigeminal artery on brain stem infarctions: a follow-up case report. ( 9617875 )
1998
25
Aberrant distribution of tyrosine hydroxylase and substance P in infants with brain-stem infarction. ( 7524264 )
1994
26
Ipsilateral hypohidrosis in brain stem infarction. ( 8418531 )
1993
27
Brain stem infarction and diaschisis. A SPECT cerebral perfusion study. ( 8342190 )
1993
28
Pediatric brain stem infarction caused by a basilar and vertebral artery occlusion: case report. ( 1513445 )
1992
29
Bilateral persistent trigeminal arteries presenting with brain-stem infarction. ( 1528434 )
1992
30
Transient amnesia heralding brain stem infarction. ( 1431969 )
1992
31
Isolated inferior oblique paresis from brain-stem infarction. Perspective on oculomotor fascicular organization in the ventral midbrain tegmentum. ( 2405823 )
1990
32
Transcranial Doppler in acute brain stem infarction. ( 2565551 )
1989
33
Brain stem infarction as a complication of giant-cell arteritis. ( 3757384 )
1986
34
Megadolichobasilar anomaly associated with brain stem infarction: a case report. ( 3971740 )
1985
35
Brain stem infarction due to chiropractic manipulation of the cervical spine. ( 6612409 )
1983
36
Brain stem infarction due to chiropractic manipulation of the cervical spine. ( 6359460 )
1983
37
Chronic electrical stimulation of the thalamic unspecific activating system in a patient with coma due to midbrain and upper brain stem infarction. ( 314229 )
1979
38
Respiratory rate and pattern disturbances in acute brain stem infarction. ( 960158 )
1976
39
Characteristics and survival of patients with brain stem infarction. ( 1154470 )
1975
40
'Iatrogenic' brain stem infarction. A complication of x-ray examination of the cervical spine and following posterior tamponation of the nose. ( 1126348 )
1975
41
Insulin-resistant diabetic coma. Acute onset in an unknown diabetic associated with brain-stem infarction and death. ( 4212098 )
1974
42
See-saw nystagmus: an unusual sign of brain-stem infarction. ( 4847304 )
1974
43
Sleep patterns in a patient with a brain stem infarction involving the raphe nucleus. ( 4135364 )
1974
44
Electroencephalogram in brain stem infarction. ( 13737459 )
1961

Variations for Brain Stem Infarction

Expression for Brain Stem Infarction

Search GEO for disease gene expression data for Brain Stem Infarction.

Pathways for Brain Stem Infarction

GO Terms for Brain Stem Infarction

Cellular components related to Brain Stem Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.16 FGB PLG
2 P-body GO:0000932 8.96 APOBEC3G CNOT3
3 platelet alpha granule lumen GO:0031093 8.62 FGB PLG

Biological processes related to Brain Stem Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.26 FGB PLG
2 platelet degranulation GO:0002576 9.16 FGB PLG
3 hemostasis GO:0007599 8.96 FGB PLG
4 fibrinolysis GO:0042730 8.62 FGB PLG

Molecular functions related to Brain Stem Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 8.62 FGB PLG

Sources for Brain Stem Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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