MCID: BRN036
MIFTS: 38

Brain Stem Infarction

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Brain Stem Infarction

MalaCards integrated aliases for Brain Stem Infarction:

Name: Brain Stem Infarction 12 15 17
Brain Stem Infarctions 45 74
Brainstem Infarction 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3523
MeSH 45 D020526
SNOMED-CT 69 95457000
UMLS 74 C0521542

Summaries for Brain Stem Infarction

Disease Ontology : 12 A brain infarction that is characterized by stroke of the brain stem that develops from blockage or narrowing in the arteries located in the brainstem, has material basis in damage to the cranial nerve nuclei and long tracts, has symptom vertigo, has symptom imbalance, has symptom decreased level of arousal.

MalaCards based summary : Brain Stem Infarction, also known as brain stem infarctions, is related to lateral medullary syndrome and basilar artery occlusion, and has symptoms including vertigo, imbalance and decreased level of arousal. An important gene associated with Brain Stem Infarction is SRPK2 (SRSF Protein Kinase 2), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Sirolimus and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and eye.

Related Diseases for Brain Stem Infarction

Graphical network of the top 20 diseases related to Brain Stem Infarction:



Diseases related to Brain Stem Infarction

Symptoms & Phenotypes for Brain Stem Infarction

Symptoms:

12
  • vertigo
  • imbalance
  • decreased level of arousal

Drugs & Therapeutics for Brain Stem Infarction

Drugs for Brain Stem Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sirolimus Approved, Investigational Phase 2, Phase 3 53123-88-9 46835353 5284616 6436030
2
Everolimus Approved Phase 2, Phase 3 159351-69-6 70789204 6442177
3
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
4 Immunologic Factors Phase 2, Phase 3
5 Antibiotics, Antitubercular Phase 2, Phase 3
6 Anti-Bacterial Agents Phase 2, Phase 3
7 Immunosuppressive Agents Phase 2, Phase 3
8 Antifungal Agents Phase 2, Phase 3
9 Anti-Infective Agents Phase 2, Phase 3
10 Pharmaceutical Solutions Phase 2, Phase 3,Phase 1
11 Anticonvulsants Phase 1, Phase 2
12 Epidiolex Phase 1, Phase 2
13
Timolol Approved Phase 1 26839-75-8 5478 33624
14
Maleic acid Experimental, Investigational Phase 1 110-17-8, 110-16-7 444972
15 Neurotransmitter Agents Phase 1
16 Lubricant Eye Drops Phase 1
17 Adrenergic Agents Phase 1
18 Adrenergic Antagonists Phase 1
19 Antihypertensive Agents Phase 1
20 Anti-Arrhythmia Agents Phase 1
21 Ophthalmic Solutions Phase 1
22 Adrenergic beta-Antagonists Phase 1
23 Immunoglobulins
24 Antibodies
25 GTPase-Activating Proteins Not Applicable

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Trial of Sirolimus for Cognitive Impairment in Sturge-Weber Syndrome Recruiting NCT03047980 Phase 2, Phase 3 Sirolimus
2 Efficacy and Safety Study of Topical Rapamycin Associated With Pulsed Dye Laser in Patients With Sturge-Weber Syndrome Completed NCT02080624 Phase 2 Drug: Topical Rapamycin
3 Cannabidiol Expanded Access Study in Medically Refractory Sturge-Weber Syndrome Active, not recruiting NCT02332655 Phase 1, Phase 2 Cannabidiol
4 Adjunctive Everolimus (RAD 001) Therapy for Epilepsy in Children With Sturge-Weber Syndrome (SWS) Withdrawn NCT01997255 Phase 2 Everolimus
5 Use of the Atkins Diet for Children With Sturge Weber Syndrome Completed NCT00639730 Phase 1
6 Treatment of Port-wine Mark in Sturge-Weber Syndrome Using Topical Timolol Terminated NCT01533376 Phase 1 Timolol;Preservative free artificial tear gel.
7 ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis Completed NCT01393444 Not Applicable
8 Transcranial Direct Current Stimulation for Dysphagia Therapy in Acute Stroke Patients Completed NCT01970384 Not Applicable
9 Biomarker Development in Sturge-Weber Syndrome Completed NCT01345305
10 Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS) Completed NCT00610402
11 Cortical Recording and Stimulating Array Brain-Machine Interface Recruiting NCT01894802 Not Applicable
12 Investigation on the Cortical Communication (CortiCom) System Recruiting NCT03567213 Not Applicable
13 BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia Recruiting NCT00912041 Not Applicable
14 Innovative Approaches to Gauge Progression of Sturge-Weber Syndrome Recruiting NCT01425944
15 French National Cohort of Children With Port Wine Stain Active, not recruiting NCT01364857 Not Applicable
16 NeuroCognitive Communicator: Safety Study Not yet recruiting NCT03100110 Not Applicable

Search NIH Clinical Center for Brain Stem Infarction

Cochrane evidence based reviews: brain stem infarctions

Genetic Tests for Brain Stem Infarction

Anatomical Context for Brain Stem Infarction

MalaCards organs/tissues related to Brain Stem Infarction:

42
Brain, Liver, Eye, Cerebellum

The Foundational Model of Anatomy Ontology organs/tissues related to Brain Stem Infarction:

20
The Brainstem

Publications for Brain Stem Infarction

Articles related to Brain Stem Infarction:

(show all 45)
# Title Authors Year
1
Brain stem infarction in a 6-year-old boy with Down syndrome. ( 30857880 )
2019
2
Brain Stem Infarction Due to Basilar Artery Dissection in a Patient with Moyamoya Disease Four Years after Successful Bilateral Revascularization Surgeries. ( 27068774 )
2016
3
Herpetic cranial polyneuritis mimicking brain stem infarction-an atypical presentation of Ramsay Hunt syndrome. ( 27251418 )
2016
4
Bilateral cerebellar and brain stem infarction resulting from vertebral artery injury following cervical trauma without radiographic damage of the spinal column: a case report. ( 24061492 )
2014
5
"Invisible" brain stem infarction at the first day. ( 24809672 )
2014
6
Brain stem infarction associated with familial Mediterranean fever and central nervous system vasculitis. ( 23710607 )
2013
7
Fatal outcome after brain stem infarction related to bilateral vertebral artery occlusion - case report of a detrimental complication of cervical spine trauma. ( 21756312 )
2011
8
Successful treatment of pulmonary aspiration due to brain stem infarction by using cough exercise based on swallowing scintigraphy: preliminary observations. ( 19387737 )
2009
9
Partial third nerve palsy involving the superior rectus and levator palpebrae muscles and distruption of central binocular vision fusion from brain stem infarction: a case report. ( 19807689 )
2009
10
Re: Poor surgical technique in cervical plating leading to vertebral artery injury and brain stem infarction--case report (Cho KH, Shin YS, Yoon SH, et al, Surg Neurol 2005;64:221-5). ( 16488269 )
2006
11
Brain stem infarction caused by proximal internal carotid artery stenosis in a patient with a persisting primitive trigeminal artery. ( 16766871 )
2006
12
Brain stem infarction: a complication of microvascular decompression for trigeminal neuralgia. ( 16936412 )
2006
13
Poor surgical technique in cervical plating leading to vertebral artery injury and brain stem infarction--case report. ( 16099249 )
2005
14
Electro-acupuncture for treatment of dysequillibrium due to cerebellum or brain stem infarction. ( 14719296 )
2003
15
Vertebrobasilar artery dissection presenting with simultaneous subarachnoid hemorrhage and brain stem infarction: case report. ( 12633950 )
2003
16
Time course of lesion development in patients with acute brain stem infarction and correlation with NIHSS score. ( 11566246 )
2001
17
Transient mutism after brain stem infarction. ( 10809658 )
2000
18
Transient mutism resolving into cerebellar speech after brain stem infarction following a traumatic injury of the vertebral artery in a child. ( 10189505 )
1999
19
Transient mutism after brain stem infarction. ( 10481795 )
1999
20
Natural course of combined limb and palatal tremor caused by cerebellar-brain stem infarction. ( 10495051 )
1999
21
Transient mutism after brain stem infarction (ref. Acta Neurochirurgia 1999, 141: 209-213) ( 10536732 )
1999
22
Xenon contrast-enhanced CT imaging of supratentorial hypoperfusion in patients with brain stem infarction. ( 10588109 )
1999
23
Transient mutism after brain stem infarction. ( 10610613 )
1999
24
Transient mutism after brain stem infarction. ( 10672311 )
1999
25
The protective effect of a persistent trigeminal artery on brain stem infarctions: a follow-up case report. ( 9617875 )
1998
26
Aberrant distribution of tyrosine hydroxylase and substance P in infants with brain-stem infarction. ( 7524264 )
1994
27
Brain stem infarction and diaschisis. A SPECT cerebral perfusion study. ( 8342190 )
1993
28
Ipsilateral hypohidrosis in brain stem infarction. ( 8418531 )
1993
29
Transient amnesia heralding brain stem infarction. ( 1431969 )
1992
30
Pediatric brain stem infarction caused by a basilar and vertebral artery occlusion: case report. ( 1513445 )
1992
31
Bilateral persistent trigeminal arteries presenting with brain-stem infarction. ( 1528434 )
1992
32
Isolated inferior oblique paresis from brain-stem infarction. Perspective on oculomotor fascicular organization in the ventral midbrain tegmentum. ( 2405823 )
1990
33
Transcranial Doppler in acute brain stem infarction. ( 2565551 )
1989
34
Brain stem infarction as a complication of giant-cell arteritis. ( 3757384 )
1986
35
Megadolichobasilar anomaly associated with brain stem infarction: a case report. ( 3971740 )
1985
36
Brain stem infarction due to chiropractic manipulation of the cervical spine. ( 6359460 )
1983
37
Brain stem infarction due to chiropractic manipulation of the cervical spine. ( 6612409 )
1983
38
Chronic electrical stimulation of the thalamic unspecific activating system in a patient with coma due to midbrain and upper brain stem infarction. ( 314229 )
1979
39
Respiratory rate and pattern disturbances in acute brain stem infarction. ( 960158 )
1976
40
'Iatrogenic' brain stem infarction. A complication of x-ray examination of the cervical spine and following posterior tamponation of the nose. ( 1126348 )
1975
41
Characteristics and survival of patients with brain stem infarction. ( 1154470 )
1975
42
Sleep patterns in a patient with a brain stem infarction involving the raphe nucleus. ( 4135364 )
1974
43
Insulin-resistant diabetic coma. Acute onset in an unknown diabetic associated with brain-stem infarction and death. ( 4212098 )
1974
44
See-saw nystagmus: an unusual sign of brain-stem infarction. ( 4847304 )
1974
45
Electroencephalogram in brain stem infarction. ( 13737459 )
1961

Variations for Brain Stem Infarction

Expression for Brain Stem Infarction

Search GEO for disease gene expression data for Brain Stem Infarction.

Pathways for Brain Stem Infarction

GO Terms for Brain Stem Infarction

Cellular components related to Brain Stem Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.16 FGB PLG
2 P-body GO:0000932 8.96 APOBEC3G CNOT3
3 platelet alpha granule lumen GO:0031093 8.62 FGB PLG

Biological processes related to Brain Stem Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.43 APOBEC3G FGB SRPK2
2 blood coagulation GO:0007596 9.37 FGB PLG
3 platelet degranulation GO:0002576 9.32 FGB PLG
4 hemostasis GO:0007599 9.16 FGB PLG
5 negative regulation of viral genome replication GO:0045071 8.96 APOBEC3G SRPK2
6 fibrinolysis GO:0042730 8.62 FGB PLG

Molecular functions related to Brain Stem Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 8.62 FGB PLG

Sources for Brain Stem Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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