MCID: BRN036
MIFTS: 39

Brain Stem Infarction

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Brain Stem Infarction

MalaCards integrated aliases for Brain Stem Infarction:

Name: Brain Stem Infarction 12 15 17
Brain Stem Infarctions 43 71
Brainstem Infarction 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3523
MeSH 43 D020526
SNOMED-CT 67 95457000
UMLS 71 C0521542

Summaries for Brain Stem Infarction

Disease Ontology : 12 A brain infarction that is characterized by stroke of the brain stem that develops from blockage or narrowing in the arteries located in the brainstem, has material basis in damage to the cranial nerve nuclei and long tracts, has symptom vertigo, has symptom imbalance, has symptom decreased level of arousal.

MalaCards based summary : Brain Stem Infarction, also known as brain stem infarctions, is related to basilar artery occlusion and internuclear ophthalmoplegia, and has symptoms including vertigo, imbalance and decreased level of arousal. An important gene associated with Brain Stem Infarction is LDB1 (LIM Domain Binding 1), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Cell adhesion_Plasmin signaling. The drugs Epidiolex and Anticonvulsants have been mentioned in the context of this disorder. Affiliated tissues include brainstem, brain and heart, and related phenotypes are craniofacial and hematopoietic system

Related Diseases for Brain Stem Infarction

Diseases related to Brain Stem Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
# Related Disease Score Top Affiliating Genes
1 basilar artery occlusion 30.6 PLG PLAT
2 internuclear ophthalmoplegia 30.2 SRPK2 HECTD4
3 obstructive hydrocephalus 30.1 PLG PLAT
4 facial paralysis 30.0 PRTN3 PLG
5 lateral medullary syndrome 11.6
6 basal ganglia cerebrovascular disease 10.4 PLG PLAT
7 anterior cerebral artery infarction 10.4 PLG PLAT
8 ligneous conjunctivitis 10.4 PLG PLAT
9 acute cor pulmonale 10.4 PLG PLAT
10 acute pulmonary heart disease 10.4 PLG PLAT
11 marantic endocarditis 10.4 PLG PLAT
12 thoracic outlet syndrome 10.4 PLG PLAT
13 inferior myocardial infarction 10.4 PLG PLAT
14 conversion disorder 10.3 PLG PLAT
15 intracranial embolism 10.3 PLG PLAT
16 basilar artery insufficiency 10.3 PLG PLAT
17 vitreous detachment 10.3 PLG PLAT
18 middle cerebral artery infarction 10.3 PLG PLAT
19 carotid artery thrombosis 10.3 PLG PLAT
20 occlusion precerebral artery 10.3 PLG PLAT
21 encephalopathy, familial, with neuroserpin inclusion bodies 10.3 PLG PLAT
22 post-thrombotic syndrome 10.3 PLG PLAT
23 intracranial thrombosis 10.3 PLG PLAT
24 thrombophilia due to activated protein c resistance 10.3 PLG PLAT
25 plexopathy 10.2 LDB1 HECTD4
26 carotid artery occlusion 10.2 PLG PLAT
27 thrombophlebitis 10.2 PLG PLAT
28 facial nerve disease 10.2 PRTN3 PLG
29 central retinal vein occlusion 10.2 PLG PLAT
30 coronary thrombosis 10.2 PLG PLAT
31 mutism 10.2
32 intermediate coronary syndrome 10.2 PLG PLAT
33 tenosynovitis 10.1 PRTN3 HECTD4
34 pulmonary artery disease 10.1 PLG PLAT
35 compartment syndrome 10.1 PLG HECTD4
36 mononeuropathy 10.1 PRTN3 HECTD4
37 tendinitis 10.1 PRTN3 HECTD4
38 central retinal artery occlusion 10.1 PRTN3 PLG PLAT
39 ocular motor apraxia 10.1
40 vertebral artery occlusion 10.1
41 dysphagia 10.1
42 cerebral arterial disease 10.0 PLG PLAT
43 endocardium disease 10.0 PRTN3 PLG
44 alternating exotropia 10.0
45 exotropia 10.0
46 bacterial meningitis 10.0
47 speech and communication disorders 10.0 PLG PLAT HECTD4
48 hepatic veno-occlusive disease 10.0 PLG PLAT
49 atrial heart septal defect 10.0 PLG PLAT LZTR1
50 ataxia and polyneuropathy, adult-onset 9.9

Graphical network of the top 20 diseases related to Brain Stem Infarction:



Diseases related to Brain Stem Infarction

Symptoms & Phenotypes for Brain Stem Infarction

Symptoms:

12
  • vertigo
  • imbalance
  • decreased level of arousal

MGI Mouse Phenotypes related to Brain Stem Infarction:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.43 LDB1 LZTR1 PCSK5 PLAT SLC6A5 ZMIZ1
2 hematopoietic system MP:0005397 9.23 LDB1 PCSK5 PLAT PLG PRTN3 SLC6A5

Drugs & Therapeutics for Brain Stem Infarction

Drugs for Brain Stem Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Epidiolex Phase 1, Phase 2
2 Anticonvulsants Phase 1, Phase 2
3
Timolol Approved Phase 1 26839-75-8 33624 5478
4
Maleic acid Experimental, Investigational Phase 1 110-17-8, 110-16-7 444972
5 Pharmaceutical Solutions Phase 1
6 Neurotransmitter Agents Phase 1
7 Anti-Arrhythmia Agents Phase 1
8 Lubricant Eye Drops Phase 1
9 Antihypertensive Agents Phase 1
10 Adrenergic beta-Antagonists Phase 1
11 Adrenergic Antagonists Phase 1
12 Ophthalmic Solutions Phase 1
13 Adrenergic Agents Phase 1
14 GTPase-Activating Proteins
15 Immunoglobulins
16 Antibodies

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Trial of Sirolimus for Cognitive Impairment in Sturge-Weber Syndrome Active, not recruiting NCT03047980 Phase 2, Phase 3 Sirolimus
2 Phase II, Randomized, Triple Blind, Intra-individually Placebo-controlled Clinical Trial to Assess the Efficacy and Safety of Topical Rapamycin Associated With Pulsed Dye Laser in Patients With Sturge-Weber Syndrome. Completed NCT02080624 Phase 2 Drug: Topical Rapamycin
3 Cannabidiol Expanded Access Study in Medically Refractory Sturge-Weber Syndrome Active, not recruiting NCT02332655 Phase 1, Phase 2 Cannabidiol
4 An Open-Label Controlled Study of Adjunctive Everolimus (RAD 001) Therapy for Epilepsy in Children With Sturge-Weber Syndrome Withdrawn NCT01997255 Phase 2 Everolimus
5 Use of the Atkins Diet for Children With Sturge Weber Syndrome Completed NCT00639730 Phase 1
6 Treatment of Port-wine Mark in Sturge-Weber Syndrome Using Topical Timolol Terminated NCT01533376 Phase 1 Timolol;Preservative free artificial tear gel.
7 French National Prospective Cohort of Children With Port Wine Stain on a Limb = "Cohorte Nationale d'Enfants Avec Angiome Plan de Membre inférieur" Unknown status NCT01364857
8 Acute Electrocorticography (ECoG) Direct Brain Interface for Individuals With Upper Limb Paralysis Completed NCT01393444
9 Establishing Reliability for Quantitative EEG, Transcranial Doppler, Behavioral Outcomes and Optical Coherence Tomography in SWS: The Next Step Toward Biomarker Development Completed NCT01345305
10 Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS) Completed NCT00610402
11 BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia Recruiting NCT00912041
12 The Brain Vascular Malformations Clinical Research Network: Predictors of Clinical Course, Project 2: Innovative Approaches to Gauge Progression of Sturge-Weber Syndrome Recruiting NCT01425944
13 A Sensorimotor Microelectrode Brain-Machine Interface for Individuals With Tetraplegia Recruiting NCT01894802
14 Investigation on the Cortical Communication (CortiCom) System Recruiting NCT03567213
15 Real World Testing of a Brain-Computer Interface to Operate a Commercial Augmentative and Alternative Communication System Recruiting NCT04026581

Search NIH Clinical Center for Brain Stem Infarction

Cochrane evidence based reviews: brain stem infarctions

Genetic Tests for Brain Stem Infarction

Anatomical Context for Brain Stem Infarction

The Foundational Model of Anatomy Ontology organs/tissues related to Brain Stem Infarction:

19
Brainstem

MalaCards organs/tissues related to Brain Stem Infarction:

40
Brain, Heart, Liver, Eye, Spinal Cord, Testes, Cerebellum

Publications for Brain Stem Infarction

Articles related to Brain Stem Infarction:

(show top 50) (show all 232)
# Title Authors PMID Year
1
Endoscopic surgical treatment of Cushing's disease: A single-center experience of cauterization of peritumoral tissues. 61
31777545 2019
2
[Catheter balloon dilation combined with acupuncture for cricopharyngeal achalasia after brain stem infarction: a randomized controlled trial]. 61
31621251 2019
3
Experience in Rehabilitation Medicine Affects Prognosis and End-of-Life Decision-Making of Neurologists: A Case-Based Survey. 61
30607828 2019
4
Brain stem infarction in a 6-year-old boy with Down syndrome. 61
30857880 2019
5
Unnecessary Cervical Epidural Injection in An Octogenarian. 61
31528446 2019
6
A cohort study of isolated brainstem infarction based on head MR imaging and clinical findings. 61
30246581 2018
7
Spinal Cord Infarction in the Region of the Posterior Spinal Artery After Embolization for Vertebral Artery Dissection. 61
29538687 2018
8
Brainstem infarction associated with HHV-6 infection in an infant. 61
28958731 2018
9
Delayed Infarction of Medullar and Cerebellum 3 Months after Vertebral Artery Injury with C1-2 Fracture: Case Report. 61
28512615 2017
10
Preventive Suboccipital Decompressive Craniectomy for Cerebellar Infarction: A Retrospective-Matched Case-Control Study. 61
27608818 2016
11
[Brain stem infarction, temporal headache, and elevated inflammatory parameters in a 74-year-old man]. 61
27055655 2016
12
Herpetic cranial polyneuritis mimicking brain stem infarction-an atypical presentation of Ramsay Hunt syndrome. 61
27251418 2016
13
Brain Stem Infarction Due to Basilar Artery Dissection in a Patient with Moyamoya Disease Four Years after Successful Bilateral Revascularization Surgeries. 61
27068774 2016
14
Microstructural abnormalities of the trigeminal nerve by diffusion-tensor imaging in trigeminal neuralgia without neurovascular compression. 61
26678753 2016
15
Ruptured Pseudoaneurysm after Gamma Knife Surgery for Vestibular Schwannoma. 61
26667081 2016
16
Severe White Matter Hyperintensity Is Associated with Early Neurological Deterioration in Patients with Isolated Pontine Infarction. 61
27532619 2016
17
Erectile dysfunction (ED) after ischemic stroke: association between prevalence and site of lesion. 61
26374302 2015
18
Acute pontine infarction after percutaneous coronary intervention: a very rare but devastating complication. 61
26037684 2015
19
Molecular hydrogen in sports medicine: new therapeutic perspectives. 61
25525953 2015
20
[Hybrid treatment of aortic arch disease with ascending aorta to carotid artery revascularization and subsequent endovascular repair]. 61
25908289 2015
21
Evaluation of the pontine perforators of the basilar artery using digital subtraction angiography in high resolution and 3D rotation technique. 61
24904054 2014
22
"Invisible" brain stem infarction at the first day. 61
24809672 2014
23
Sudden unexpected death owing to unilateral medial medullary infarction with early involvement of the respiratory center. 61
24508471 2014
24
Posterior circulation hyperperfusion syndrome after superficial temporal artery-superior cerebellar artery bypass for vertebral artery dissection. 61
23721618 2014
25
[Cervical cord infarction associated with unilateral vertebral artery dissection due to golf swing]. 61
24583591 2014
26
Bilateral cerebellar and brain stem infarction resulting from vertebral artery injury following cervical trauma without radiographic damage of the spinal column: a case report. 61
24061492 2014
27
Isolated third, fourth, and sixth cranial nerve palsies from presumed microvascular versus other causes: a prospective study. 61
23747163 2013
28
[Long-term results of open stent-grafting applied with a Matsui-Kitamura( MK) stent in treatment of arch aneurysm]. 61
24105114 2013
29
A case of peduncular hallucinosis presenting as a primary psychiatric disorder. 61
24339609 2013
30
Brain stem infarction associated with familial Mediterranean fever and central nervous system vasculitis. 61
23710607 2013
31
Giant aneurysm of the basilar artery in an 86 year old woman. 61
24358886 2013
32
[Conversion of a retrograde access to an antegrade access for bilateral femorocrural intervention in one session]. 61
22549552 2012
33
Waffle-Cone Technique Using Solitaire AB Stent. 61
22737303 2012
34
Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. 61
22720117 2012
35
[Dysphagia in Avellis' syndrome]. 61
22373552 2012
36
Should intentional endovascular stent-graft coverage of the left subclavian artery be preceded by prophylactic revascularisation? 61
21376612 2011
37
Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. 61
22146674 2011
38
Fatal outcome after brain stem infarction related to bilateral vertebral artery occlusion - case report of a detrimental complication of cervical spine trauma. 61
21756312 2011
39
Early single center experience with the solitaire thrombectomy device for the treatment of acute ischemic stroke. 61
21696665 2011
40
[An evaluation of clinical characteristics and prognosis of brain-stem infarction in diabetics]. 61
21418884 2011
41
Spontaneous regression of an anterior skull base mass. 61
20356749 2010
42
Hybrid treatment of aberrant right subclavian artery and its aneurysms. 61
20690521 2010
43
Endovascular management of vertebral artery dissecting aneurysms: review of 25 patients. 61
20401839 2010
44
Simultaneous unilateral internal carotid artery and occlusive basilar artery dissections. 61
20121537 2010
45
Clinical presentation of intracranial epidermoids: a surgical series of 20 initial and four recurred cases. 61
22028741 2010
46
Surgical treatment of intracranial VA dissecting aneurysm. 61
19953371 2010
47
Successful treatment of pulmonary aspiration due to brain stem infarction by using cough exercise based on swallowing scintigraphy: preliminary observations. 61
19387737 2009
48
[A case of brainstem variant of reversible posterior leukoencephalopathy syndrome]. 61
19938667 2009
49
Contrast extravasation after bilateral inferior petrosal sinus sampling masquerading as venous subarachnoid haemorrhage. 61
19960150 2009
50
Endovascular strategies for vertebrobasilar dissecting aneurysms. 61
19474118 2009

Variations for Brain Stem Infarction

Expression for Brain Stem Infarction

Search GEO for disease gene expression data for Brain Stem Infarction.

Pathways for Brain Stem Infarction

Pathways related to Brain Stem Infarction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.33 PRTN3 PLG PLAT
2 11.01 PLG PLAT
3 10.94 PLG PLAT
4 10.52 PLG PLAT
5 9.74 PLG PLAT

GO Terms for Brain Stem Infarction

Biological processes related to Brain Stem Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.56 PRTN3 PLG PLAT PCSK5
2 blood coagulation GO:0007596 9.33 PRTN3 PLG PLAT
3 fibrinolysis GO:0042730 8.96 PLG PLAT
4 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 8.62 PLG PLAT

Molecular functions related to Brain Stem Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.62 PRTN3 PLG PLAT PCSK5
2 transcription coregulator activity GO:0003712 9.43 ZMIZ1 PIAS2 LDB1
3 serine-type endopeptidase activity GO:0004252 9.26 PRTN3 PLG PLAT PCSK5
4 SUMO ligase activity GO:0061665 9.16 ZMIZ1 PIAS2
5 serine-type peptidase activity GO:0008236 8.92 PRTN3 PLG PLAT PCSK5

Sources for Brain Stem Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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