MCID: BRN036
MIFTS: 37

Brain Stem Infarction

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Brain Stem Infarction

MalaCards integrated aliases for Brain Stem Infarction:

Name: Brain Stem Infarction 12 15 17
Brain Stem Infarctions 44 72
Brainstem Infarction 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3523
MeSH 44 D020526
SNOMED-CT 68 95457000
UMLS 72 C0521542

Summaries for Brain Stem Infarction

Disease Ontology : 12 A brain infarction that is characterized by stroke of the brain stem that develops from blockage or narrowing in the arteries located in the brainstem, has material basis in damage to the cranial nerve nuclei and long tracts, has symptom vertigo, has symptom imbalance, has symptom decreased level of arousal.

MalaCards based summary : Brain Stem Infarction, also known as brain stem infarctions, is related to lateral medullary syndrome and basilar artery occlusion, and has symptoms including vertigo, imbalance and decreased level of arousal. An important gene associated with Brain Stem Infarction is SRPK2 (SRSF Protein Kinase 2), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Epidiolex and Anticonvulsants have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye.

Related Diseases for Brain Stem Infarction

Diseases related to Brain Stem Infarction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 lateral medullary syndrome 31.8 PLG FGB
2 basilar artery occlusion 29.2 PLG APOBEC3G
3 mutism 10.2
4 ocular motor apraxia 10.1
5 vertebral artery occlusion 10.1
6 dysphagia 10.0
7 alternating exotropia 10.0
8 exotropia 10.0
9 bacterial meningitis 10.0
10 ataxia and polyneuropathy, adult-onset 9.9
11 hemiplegia 9.9
12 quadriplegia 9.9
13 vasculitis 9.9
14 pathologic nystagmus 9.9
15 sarcoidosis 1 9.9
16 kearns-sayre syndrome 9.9
17 sleep apnea 9.9
18 thrombosis 9.9
19 internuclear ophthalmoplegia 9.9
20 herpes zoster 9.9
21 tuberculous meningitis 9.9
22 autonomic dysfunction 9.9
23 abducens palsy 9.8
24 hypercholesterolemia, familial, 1 9.8
25 systemic lupus erythematosus 9.8
26 myoclonus and ataxia 9.8
27 temporal arteritis 9.8
28 trigeminal neuralgia 9.8
29 down syndrome 9.8
30 familial mediterranean fever 9.8
31 moyamoya disease 1 9.8
32 myxedema 9.8
33 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.8
34 autosomal recessive disease 9.8
35 aphasia 9.8
36 endocarditis 9.8
37 partial third-nerve palsy 9.8
38 hydrocephalus 9.8
39 amnestic disorder 9.8
40 intracranial aneurysm 9.8
41 anhidrosis 9.8
42 pica disease 9.8
43 neutropenia 9.8
44 locked-in syndrome 9.8
45 carotid stenosis 9.8
46 hypothyroidism 9.8
47 lymphadenitis 9.8
48 ventricular septal defect 9.8
49 heart septal defect 9.8
50 transient cerebral ischemia 9.8

Graphical network of the top 20 diseases related to Brain Stem Infarction:



Diseases related to Brain Stem Infarction

Symptoms & Phenotypes for Brain Stem Infarction

Symptoms:

12
  • vertigo
  • imbalance
  • decreased level of arousal

Drugs & Therapeutics for Brain Stem Infarction

Drugs for Brain Stem Infarction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Epidiolex Phase 1, Phase 2
2 Anticonvulsants Phase 1, Phase 2
3
Timolol Approved Phase 1 26839-75-8 33624 5478
4
Maleic acid Experimental, Investigational Phase 1 110-17-8, 110-16-7 444972
5 Pharmaceutical Solutions Phase 1
6 Neurotransmitter Agents Phase 1
7 Antihypertensive Agents Phase 1
8 Ophthalmic Solutions Phase 1
9 Adrenergic Antagonists Phase 1
10 Lubricant Eye Drops Phase 1
11 Adrenergic beta-Antagonists Phase 1
12 Adrenergic Agents Phase 1
13 Anti-Arrhythmia Agents Phase 1
14 Antibodies
15 Immunoglobulins
16 GTPase-Activating Proteins

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Trial of Sirolimus for Cognitive Impairment in Sturge-Weber Syndrome Active, not recruiting NCT03047980 Phase 2, Phase 3 Sirolimus
2 Phase II, Randomized, Triple Blind, Intra-individually Placebo-controlled Clinical Trial to Assess the Efficacy and Safety of Topical Rapamycin Associated With Pulsed Dye Laser in Patients With Sturge-Weber Syndrome. Completed NCT02080624 Phase 2 Drug: Topical Rapamycin
3 Cannabidiol Expanded Access Study in Medically Refractory Sturge-Weber Syndrome Active, not recruiting NCT02332655 Phase 1, Phase 2 Cannabidiol
4 An Open-Label Controlled Study of Adjunctive Everolimus (RAD 001) Therapy for Epilepsy in Children With Sturge-Weber Syndrome Withdrawn NCT01997255 Phase 2 Everolimus
5 Use of the Atkins Diet for Children With Sturge Weber Syndrome Completed NCT00639730 Phase 1
6 Treatment of Port-wine Mark in Sturge-Weber Syndrome Using Topical Timolol Terminated NCT01533376 Phase 1 Timolol;Preservative free artificial tear gel.
7 Acute Electrocorticography (ECoG) Direct Brain Interface for Individuals With Upper Limb Paralysis Completed NCT01393444
8 Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS) Completed NCT00610402
9 Establishing Reliability for Quantitative EEG, Transcranial Doppler, Behavioral Outcomes and Optical Coherence Tomography in SWS: The Next Step Toward Biomarker Development Completed NCT01345305
10 BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia Recruiting NCT00912041
11 The Brain Vascular Malformations Clinical Research Network: Predictors of Clinical Course, Project 2: Innovative Approaches to Gauge Progression of Sturge-Weber Syndrome Recruiting NCT01425944
12 A Sensorimotor Microelectrode Brain-Machine Interface for Individuals With Tetraplegia Recruiting NCT01894802
13 Investigation on the Cortical Communication (CortiCom) System Recruiting NCT03567213
14 Real World Testing of a Brain-Computer Interface to Operate a Commercial Augmentative and Alternative Communication System Recruiting NCT04026581
15 French National Prospective Cohort of Children With Port Wine Stain on a Limb = "Cohorte Nationale d'Enfants Avec Angiome Plan de Membre inférieur" Active, not recruiting NCT01364857

Search NIH Clinical Center for Brain Stem Infarction

Cochrane evidence based reviews: brain stem infarctions

Genetic Tests for Brain Stem Infarction

Anatomical Context for Brain Stem Infarction

MalaCards organs/tissues related to Brain Stem Infarction:

41
Brain, Testes, Eye, Cerebellum, Heart, Spinal Cord, Cortex

The Foundational Model of Anatomy Ontology organs/tissues related to Brain Stem Infarction:

19
Brainstem

Publications for Brain Stem Infarction

Articles related to Brain Stem Infarction:

(show top 50) (show all 229)
# Title Authors PMID Year
1
Experience in Rehabilitation Medicine Affects Prognosis and End-of-Life Decision-Making of Neurologists: A Case-Based Survey. 38
30607828 2019
2
Brain stem infarction in a 6-year-old boy with Down syndrome. 38
30857880 2019
3
A cohort study of isolated brainstem infarction based on head MR imaging and clinical findings. 38
30246581 2018
4
Spinal Cord Infarction in the Region of the Posterior Spinal Artery After Embolization for Vertebral Artery Dissection. 38
29538687 2018
5
Brainstem infarction associated with HHV-6 infection in an infant. 38
28958731 2018
6
Delayed Infarction of Medullar and Cerebellum 3 Months after Vertebral Artery Injury with C1-2 Fracture: Case Report. 38
28512615 2017
7
Preventive Suboccipital Decompressive Craniectomy for Cerebellar Infarction: A Retrospective-Matched Case-Control Study. 38
27608818 2016
8
[Brain stem infarction, temporal headache, and elevated inflammatory parameters in a 74-year-old man]. 38
27055655 2016
9
Herpetic cranial polyneuritis mimicking brain stem infarction-an atypical presentation of Ramsay Hunt syndrome. 38
27251418 2016
10
Brain Stem Infarction Due to Basilar Artery Dissection in a Patient with Moyamoya Disease Four Years after Successful Bilateral Revascularization Surgeries. 38
27068774 2016
11
Microstructural abnormalities of the trigeminal nerve by diffusion-tensor imaging in trigeminal neuralgia without neurovascular compression. 38
26678753 2016
12
Ruptured Pseudoaneurysm after Gamma Knife Surgery for Vestibular Schwannoma. 38
26667081 2016
13
Severe White Matter Hyperintensity Is Associated with Early Neurological Deterioration in Patients with Isolated Pontine Infarction. 38
27532619 2016
14
Erectile dysfunction (ED) after ischemic stroke: association between prevalence and site of lesion. 38
26374302 2015
15
Acute pontine infarction after percutaneous coronary intervention: a very rare but devastating complication. 38
26037684 2015
16
Molecular hydrogen in sports medicine: new therapeutic perspectives. 38
25525953 2015
17
[Hybrid treatment of aortic arch disease with ascending aorta to carotid artery revascularization and subsequent endovascular repair]. 38
25908289 2015
18
Evaluation of the pontine perforators of the basilar artery using digital subtraction angiography in high resolution and 3D rotation technique. 38
24904054 2014
19
"Invisible" brain stem infarction at the first day. 38
24809672 2014
20
Sudden unexpected death owing to unilateral medial medullary infarction with early involvement of the respiratory center. 38
24508471 2014
21
Posterior circulation hyperperfusion syndrome after superficial temporal artery-superior cerebellar artery bypass for vertebral artery dissection. 38
23721618 2014
22
[Cervical cord infarction associated with unilateral vertebral artery dissection due to golf swing]. 38
24583591 2014
23
Bilateral cerebellar and brain stem infarction resulting from vertebral artery injury following cervical trauma without radiographic damage of the spinal column: a case report. 38
24061492 2014
24
Isolated third, fourth, and sixth cranial nerve palsies from presumed microvascular versus other causes: a prospective study. 38
23747163 2013
25
[Long-term results of open stent-grafting applied with a Matsui-Kitamura( MK) stent in treatment of arch aneurysm]. 38
24105114 2013
26
A case of peduncular hallucinosis presenting as a primary psychiatric disorder. 38
24339609 2013
27
Brain stem infarction associated with familial Mediterranean fever and central nervous system vasculitis. 38
23710607 2013
28
Giant aneurysm of the basilar artery in an 86 year old woman. 38
24358886 2013
29
[Conversion of a retrograde access to an antegrade access for bilateral femorocrural intervention in one session]. 38
22549552 2012
30
Waffle-Cone Technique Using Solitaire AB Stent. 38
22737303 2012
31
Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. 38
22720117 2012
32
[Dysphagia in Avellis' syndrome]. 38
22373552 2012
33
Should intentional endovascular stent-graft coverage of the left subclavian artery be preceded by prophylactic revascularisation? 38
21376612 2011
34
Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. 38
22146674 2011
35
Fatal outcome after brain stem infarction related to bilateral vertebral artery occlusion - case report of a detrimental complication of cervical spine trauma. 38
21756312 2011
36
Early single center experience with the solitaire thrombectomy device for the treatment of acute ischemic stroke. 38
21696665 2011
37
[An evaluation of clinical characteristics and prognosis of brain-stem infarction in diabetics]. 38
21418884 2011
38
Spontaneous regression of an anterior skull base mass. 38
20356749 2010
39
Hybrid treatment of aberrant right subclavian artery and its aneurysms. 38
20690521 2010
40
Endovascular management of vertebral artery dissecting aneurysms: review of 25 patients. 38
20401839 2010
41
Simultaneous unilateral internal carotid artery and occlusive basilar artery dissections. 38
20121537 2010
42
Clinical presentation of intracranial epidermoids: a surgical series of 20 initial and four recurred cases. 38
22028741 2010
43
Surgical treatment of intracranial VA dissecting aneurysm. 38
19953371 2010
44
Successful treatment of pulmonary aspiration due to brain stem infarction by using cough exercise based on swallowing scintigraphy: preliminary observations. 38
19387737 2009
45
[A case of brainstem variant of reversible posterior leukoencephalopathy syndrome]. 38
19938667 2009
46
Contrast extravasation after bilateral inferior petrosal sinus sampling masquerading as venous subarachnoid haemorrhage. 38
19960150 2009
47
Endovascular strategies for vertebrobasilar dissecting aneurysms. 38
19474118 2009
48
Long-term outcome after suboccipital decompressive craniectomy for malignant cerebellar infarction. 38
19574555 2009
49
Classical crossed brain stem syndromes: myth or reality? 38
19252797 2009
50
Fatal diquat intoxication. 38
19583147 2009

Variations for Brain Stem Infarction

Expression for Brain Stem Infarction

Search GEO for disease gene expression data for Brain Stem Infarction.

Pathways for Brain Stem Infarction

GO Terms for Brain Stem Infarction

Cellular components related to Brain Stem Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.16 PLG FGB
2 P-body GO:0000932 8.96 CNOT3 APOBEC3G
3 platelet alpha granule lumen GO:0031093 8.62 PLG FGB

Biological processes related to Brain Stem Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.43 SRPK2 FGB APOBEC3G
2 blood coagulation GO:0007596 9.37 PLG FGB
3 platelet degranulation GO:0002576 9.32 PLG FGB
4 hemostasis GO:0007599 9.16 PLG FGB
5 negative regulation of viral genome replication GO:0045071 8.96 SRPK2 APOBEC3G
6 fibrinolysis GO:0042730 8.62 PLG FGB

Molecular functions related to Brain Stem Infarction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 8.62 PLG FGB

Sources for Brain Stem Infarction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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