MCID: BRN116
MIFTS: 18

Brain Stem Medulloblastoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Stem Medulloblastoma

MalaCards integrated aliases for Brain Stem Medulloblastoma:

Name: Brain Stem Medulloblastoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050899

Summaries for Brain Stem Medulloblastoma

Disease Ontology : 12 A brain stem cancer that begins in the lower part of the brain on the floor of the skull.

MalaCards based summary : Brain Stem Medulloblastoma is related to nodular medulloblastoma and adamantinous craniopharyngioma. An important gene associated with Brain Stem Medulloblastoma is SHH (Sonic Hedgehog Signaling Molecule), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. Affiliated tissues include brain, and related phenotype is taste/olfaction.

Related Diseases for Brain Stem Medulloblastoma

Diseases related to Brain Stem Medulloblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 nodular medulloblastoma 9.7 SHH CTNNB1
2 adamantinous craniopharyngioma 9.7 SHH CTNNB1
3 townes-brocks syndrome 9.6 SHH CTNNB1
4 basal cell nevus syndrome 9.6 SHH CTNNB1
5 infratentorial cancer 9.6 SHH CTNNB1
6 teratoma 9.6 SHH CTNNB1
7 li-fraumeni syndrome 9.6 SHH CTNNB1
8 basal cell carcinoma 9.6 SHH CTNNB1
9 lung squamous cell carcinoma 9.5 SHH CTNNB1
10 microphthalmia 9.5 SHH CTNNB1
11 pancreatic adenocarcinoma 9.4 SHH CTNNB1
12 brain cancer 9.2 SHH CTNNB1

Graphical network of the top 20 diseases related to Brain Stem Medulloblastoma:



Diseases related to Brain Stem Medulloblastoma

Symptoms & Phenotypes for Brain Stem Medulloblastoma

MGI Mouse Phenotypes related to Brain Stem Medulloblastoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.62 CTNNB1 SHH

Drugs & Therapeutics for Brain Stem Medulloblastoma

Search Clinical Trials , NIH Clinical Center for Brain Stem Medulloblastoma

Genetic Tests for Brain Stem Medulloblastoma

Anatomical Context for Brain Stem Medulloblastoma

MalaCards organs/tissues related to Brain Stem Medulloblastoma:

40
Brain

Publications for Brain Stem Medulloblastoma

Articles related to Brain Stem Medulloblastoma:

# Title Authors PMID Year
1
Multiple intracranial meningiomas causing papilledema and visual loss in a patient with nevoid Basal cell carcinoma syndrome. 61
18347458 2008

Variations for Brain Stem Medulloblastoma

Expression for Brain Stem Medulloblastoma

Search GEO for disease gene expression data for Brain Stem Medulloblastoma.

Pathways for Brain Stem Medulloblastoma

Pathways related to Brain Stem Medulloblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.13 SHH CTNNB1
2
Show member pathways
12.03 SHH CTNNB1
3
Show member pathways
11.81 SHH CTNNB1
4 11.57 SHH CTNNB1
5 11.42 SHH CTNNB1
6 11.11 SHH CTNNB1
7 10.29 SHH CTNNB1

GO Terms for Brain Stem Medulloblastoma

Biological processes related to Brain Stem Medulloblastoma according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.69 SHH CTNNB1
2 positive regulation of cell proliferation GO:0008284 9.68 SHH CTNNB1
3 positive regulation of gene expression GO:0010628 9.68 SHH CTNNB1
4 negative regulation of gene expression GO:0010629 9.68 SHH CTNNB1
5 heart development GO:0007507 9.68 SHH CTNNB1
6 regulation of gene expression GO:0010468 9.67 SHH CTNNB1
7 cell proliferation GO:0008283 9.67 SHH CTNNB1
8 regulation of cell proliferation GO:0042127 9.67 SHH CTNNB1
9 kidney development GO:0001822 9.66 SHH CTNNB1
10 lung development GO:0030324 9.66 SHH CTNNB1
11 forebrain development GO:0030900 9.65 SHH CTNNB1
12 canonical Wnt signaling pathway GO:0060070 9.65 SHH CTNNB1
13 negative regulation of cell differentiation GO:0045596 9.65 SHH CTNNB1
14 vasculogenesis GO:0001570 9.64 SHH CTNNB1
15 odontogenesis of dentin-containing tooth GO:0042475 9.64 SHH CTNNB1
16 embryonic digit morphogenesis GO:0042733 9.63 SHH CTNNB1
17 thymus development GO:0048538 9.63 SHH CTNNB1
18 skin development GO:0043588 9.62 SHH CTNNB1
19 limb development GO:0060173 9.62 SHH CTNNB1
20 branching involved in ureteric bud morphogenesis GO:0001658 9.61 SHH CTNNB1
21 dorsal/ventral pattern formation GO:0009953 9.61 SHH CTNNB1
22 midbrain development GO:0030901 9.6 SHH CTNNB1
23 cell fate specification GO:0001708 9.59 SHH CTNNB1
24 embryonic forelimb morphogenesis GO:0035115 9.58 SHH CTNNB1
25 T cell differentiation in thymus GO:0033077 9.58 SHH CTNNB1
26 pancreas development GO:0031016 9.57 SHH CTNNB1
27 embryonic hindlimb morphogenesis GO:0035116 9.56 SHH CTNNB1
28 branching involved in blood vessel morphogenesis GO:0001569 9.55 SHH CTNNB1
29 hair follicle morphogenesis GO:0031069 9.54 SHH CTNNB1
30 vasculature development GO:0001944 9.52 SHH CTNNB1
31 positive regulation of mesenchymal cell proliferation GO:0002053 9.51 SHH CTNNB1
32 positive regulation of neuroblast proliferation GO:0002052 9.49 SHH CTNNB1
33 hindbrain development GO:0030902 9.48 SHH CTNNB1
34 male genitalia development GO:0030539 9.46 SHH CTNNB1
35 epithelial tube branching involved in lung morphogenesis GO:0060441 9.43 SHH CTNNB1
36 ectoderm development GO:0007398 9.4 SHH CTNNB1
37 embryonic foregut morphogenesis GO:0048617 9.37 SHH CTNNB1
38 lung-associated mesenchyme development GO:0060484 9.32 SHH CTNNB1
39 positive regulation of skeletal muscle tissue development GO:0048643 9.26 SHH CTNNB1
40 trachea morphogenesis GO:0060439 9.16 SHH CTNNB1
41 mesenchymal cell proliferation involved in lung development GO:0060916 8.96 SHH CTNNB1
42 positive regulation of epithelial cell proliferation involved in prostate gland development GO:0060769 8.62 SHH CTNNB1

Sources for Brain Stem Medulloblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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