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MCID: BRN116
MIFTS: 19

Brain Stem Medulloblastoma

Categories: Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Brain Stem Medulloblastoma

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MalaCards integrated aliases for Brain Stem Medulloblastoma:

Name: Brain Stem Medulloblastoma 12 15

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050899
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Summaries for Brain Stem Medulloblastoma

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Disease Ontology : 12 A brain stem cancer that begins in the lower part of the brain on the floor of the skull.

MalaCards based summary : Brain Stem Medulloblastoma is related to nodular medulloblastoma and adamantinous craniopharyngioma. An important gene associated with Brain Stem Medulloblastoma is SHH (Sonic Hedgehog Signaling Molecule), and among its related pathways/superpathways are Gastric cancer and Translation Non-genomic (rapid) action of Androgen Receptor. Affiliated tissues include brain, and related phenotype is taste/olfaction.

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Related Diseases for Brain Stem Medulloblastoma

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Diseases related to Brain Stem Medulloblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)
# Related Disease Score Top Affiliating Genes
1 nodular medulloblastoma 9.8 SHH CTNNB1
2 adamantinous craniopharyngioma 9.8 SHH CTNNB1
3 focal dermal hypoplasia 9.8 SHH CTNNB1
4 anus, imperforate 9.8 SHH CTNNB1
5 townes-brocks syndrome 9.8 SHH CTNNB1
6 hyaline fibromatosis syndrome 9.8 SHH CTNNB1
7 infratentorial cancer 9.8 SHH CTNNB1
8 atypical teratoid rhabdoid tumor 9.8 SHH CTNNB1
9 basal cell nevus syndrome 9.8 SHH CTNNB1
10 teratoma 9.8 SHH CTNNB1
11 renal hypodysplasia/aplasia 1 9.8 SHH CTNNB1
12 peutz-jeghers syndrome 9.8 SHH CTNNB1
13 li-fraumeni syndrome 9.8 SHH CTNNB1
14 central nervous system cancer 9.8 SHH CTNNB1
15 tooth agenesis 9.8 SHH CTNNB1
16 orofacial cleft 9.8 SHH CTNNB1
17 odontochondrodysplasia 9.7 SHH CTNNB1
18 brain cancer 9.7 SHH CTNNB1
19 nephronophthisis 9.7 SHH CTNNB1
20 cleft palate, isolated 9.7 SHH CTNNB1
21 basal cell carcinoma 9.7 SHH CTNNB1
22 leber plus disease 9.6 SHH CTNNB1
23 microphthalmia 9.6 SHH CTNNB1
24 rhabdomyosarcoma 9.5 SHH CTNNB1

Graphical network of the top 20 diseases related to Brain Stem Medulloblastoma:



Diseases related to Brain Stem Medulloblastoma
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Symptoms & Phenotypes for Brain Stem Medulloblastoma

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MGI Mouse Phenotypes related to Brain Stem Medulloblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 taste/olfaction MP:0005394 8.62 CTNNB1 SHH
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Drugs & Therapeutics for Brain Stem Medulloblastoma

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Search Clinical Trials , NIH Clinical Center for Brain Stem Medulloblastoma

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Genetic Tests for Brain Stem Medulloblastoma

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Anatomical Context for Brain Stem Medulloblastoma

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MalaCards organs/tissues related to Brain Stem Medulloblastoma:

40
Brain
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Publications for Brain Stem Medulloblastoma

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Articles related to Brain Stem Medulloblastoma:

# Title Authors PMID Year
1
Multiple intracranial meningiomas causing papilledema and visual loss in a patient with nevoid Basal cell carcinoma syndrome. 61
18347458 2008
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Variations for Brain Stem Medulloblastoma

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Expression for Brain Stem Medulloblastoma

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Search GEO for disease gene expression data for Brain Stem Medulloblastoma.
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Pathways for Brain Stem Medulloblastoma

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Pathways related to Brain Stem Medulloblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Gastric cancer 36
Show member pathways
 12.03 SHH CTNNB1
2
Translation Non-genomic (rapid) action of Androgen Receptor 23
Show member pathways
 11.64 SHH CTNNB1
3
Proteoglycans in cancer 36
11.57 SHH CTNNB1
4
Wnt / Hedgehog / Notch 4
11.42 SHH CTNNB1
5
Ectoderm Differentiation 1
11.11 SHH CTNNB1
6
Heart Development 1
10.29 SHH CTNNB1
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GO Terms for Brain Stem Medulloblastoma

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Biological processes related to Brain Stem Medulloblastoma according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.68 SHH CTNNB1
2 regulation of gene expression GO:0010468 9.68 SHH CTNNB1
3 negative regulation of gene expression GO:0010629 9.68 SHH CTNNB1
4 heart development GO:0007507 9.68 SHH CTNNB1
5 regulation of cell proliferation GO:0042127 9.67 SHH CTNNB1
6 cell proliferation GO:0008283 9.67 SHH CTNNB1
7 kidney development GO:0001822 9.67 SHH CTNNB1
8 lung development GO:0030324 9.66 SHH CTNNB1
9 forebrain development GO:0030900 9.66 SHH CTNNB1
10 canonical Wnt signaling pathway GO:0060070 9.65 SHH CTNNB1
11 vasculogenesis GO:0001570 9.65 SHH CTNNB1
12 negative regulation of cell differentiation GO:0045596 9.65 SHH CTNNB1
13 odontogenesis of dentin-containing tooth GO:0042475 9.64 SHH CTNNB1
14 embryonic digit morphogenesis GO:0042733 9.64 SHH CTNNB1
15 thymus development GO:0048538 9.63 SHH CTNNB1
16 skin development GO:0043588 9.63 SHH CTNNB1
17 limb development GO:0060173 9.62 SHH CTNNB1
18 embryonic organ development GO:0048568 9.62 SHH CTNNB1
19 dorsal/ventral pattern formation GO:0009953 9.61 SHH CTNNB1
20 branching involved in ureteric bud morphogenesis GO:0001658 9.61 SHH CTNNB1
21 cell fate specification GO:0001708 9.6 SHH CTNNB1
22 T cell differentiation in thymus GO:0033077 9.59 SHH CTNNB1
23 midbrain development GO:0030901 9.58 SHH CTNNB1
24 embryonic forelimb morphogenesis GO:0035115 9.58 SHH CTNNB1
25 branching involved in blood vessel morphogenesis GO:0001569 9.57 SHH CTNNB1
26 embryonic hindlimb morphogenesis GO:0035116 9.56 SHH CTNNB1
27 hair follicle morphogenesis GO:0031069 9.55 SHH CTNNB1
28 pancreas development GO:0031016 9.54 SHH CTNNB1
29 vasculature development GO:0001944 9.52 SHH CTNNB1
30 positive regulation of neuroblast proliferation GO:0002052 9.51 SHH CTNNB1
31 positive regulation of mesenchymal cell proliferation GO:0002053 9.49 SHH CTNNB1
32 hindbrain development GO:0030902 9.48 SHH CTNNB1
33 epithelial tube branching involved in lung morphogenesis GO:0060441 9.46 SHH CTNNB1
34 male genitalia development GO:0030539 9.43 SHH CTNNB1
35 ectoderm development GO:0007398 9.4 SHH CTNNB1
36 positive regulation of skeletal muscle tissue development GO:0048643 9.37 SHH CTNNB1
37 embryonic foregut morphogenesis GO:0048617 9.32 SHH CTNNB1
38 lung-associated mesenchyme development GO:0060484 9.26 SHH CTNNB1
39 trachea morphogenesis GO:0060439 9.16 SHH CTNNB1
40 mesenchymal cell proliferation involved in lung development GO:0060916 8.96 SHH CTNNB1
41 positive regulation of epithelial cell proliferation involved in prostate gland development GO:0060769 8.62 SHH CTNNB1
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Sources for Brain Stem Medulloblastoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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