MCID: BRN026
MIFTS: 43

Branch Retinal Artery Occlusion

Categories: Cardiovascular diseases, Eye diseases

Aliases & Classifications for Branch Retinal Artery Occlusion

MalaCards integrated aliases for Branch Retinal Artery Occlusion:

Name: Branch Retinal Artery Occlusion 12 15 71
Retinal Artery Occlusion 43 71
Arterial Retinal Branch Occlusion 12
Retinal Arterial Branch Occlusion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13094
ICD9CM 34 362.32
MeSH 43 D015356
NCIt 49 C34436
SNOMED-CT 67 50821009
ICD10 32 H34.23
UMLS 71 C0006123 C0035302

Summaries for Branch Retinal Artery Occlusion

MalaCards based summary : Branch Retinal Artery Occlusion, also known as retinal artery occlusion, is related to carotid stenosis and arteritic anterior ischemic optic neuropathy, and has symptoms including amaurosis fugax An important gene associated with Branch Retinal Artery Occlusion is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Folate Metabolism and Formation of Fibrin Clot (Clotting Cascade). The drugs Salicylic acid and Acetazolamide have been mentioned in the context of this disorder. Affiliated tissues include eye, heart and retina, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Branch Retinal Artery Occlusion

Diseases related to Branch Retinal Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 515)
# Related Disease Score Top Affiliating Genes
1 carotid stenosis 30.9 VEGFA MTHFR CRP
2 arteritic anterior ischemic optic neuropathy 30.6 MTHFR F2
3 retinal vascular occlusion 30.6 VEGFA SERPINC1 PLG MTHFR FANCG F2
4 retinal artery occlusion 30.6 VEGFA SERPINC1 PLG MTHFR FANCG F2
5 neovascular glaucoma 30.5 VEGFA PLG
6 homocysteinemia 30.5 SERPINC1 MTHFR F2 CRP
7 macular retinal edema 30.5 VEGFA PLG FANCG
8 sneddon syndrome 30.4 SERPINC1 F2
9 prothrombin-related thrombophilia 30.3 MTHFR F2
10 retinal vascular disease 30.3 VEGFA PLG MTHFR CRP
11 endocarditis 30.2 SERPINC1 F2 CRP
12 cavernous sinus thrombosis 30.2 SERPINC1 F2 CRP
13 central nervous system vasculitis 30.2 CRP BLOC1S6
14 vitreous detachment 30.1 VEGFA PLG
15 heparin-induced thrombocytopenia 30.1 SERPINC1 F3
16 catastrophic antiphospholipid syndrome 30.1 MTHFR F3
17 optic nerve disease 30.0 VEGFA CRP CCNDBP1 BLOC1S6
18 buerger disease 29.9 MTHFR F2
19 rubeosis iridis 29.9 VEGFA PLG FANCG
20 facial paralysis 29.8 PLG CRP
21 migraine with or without aura 1 29.8 PLG MTHFR F2 CRP
22 intracranial hypertension, idiopathic 29.8 F3 F2
23 retinal vein occlusion 29.8 VEGFA SERPINC1 MTHFR F3 F2
24 portal vein thrombosis 29.7 SERPINC1 MTHFR F2 CRP
25 eclampsia 29.6 VEGFA SERPINC1 MTHFR F2
26 arteriosclerosis 29.6 SERPINC1 F3 CRP
27 macular holes 29.6 VEGFA PLG
28 endophthalmitis 29.6 VEGFA PLG CRP
29 hemangioma 29.6 VEGFA F3 F2
30 heart valve disease 29.5 F3 F2 CRP
31 exanthem 29.4 VEGFA F3 F2 CRP
32 macular degeneration, age-related, 1 29.4 VEGFA PLG FANCG CRP
33 livedoid vasculitis 29.4 SERPINC1 PLG MTHFR F2
34 protein s deficiency 29.4 SERPINC1 MTHFR F3 F2
35 thrombophilia due to thrombin defect 29.4 SERPINC1 MTHFR F3 F2
36 antiphospholipid syndrome 29.3 SERPINC1 MTHFR F3 F2 CRP
37 arteries, anomalies of 29.3 VEGFA PLG F3 CRP
38 carotid artery disease 29.3 PLG F3 CRP
39 atherosclerosis susceptibility 29.3 VEGFA MTHFR F3 CRP
40 nonarteritic anterior ischemic optic neuropathy 29.3 VEGFA SERPINC1 MTHFR F2 CRP BLOC1S6
41 takayasu arteritis 29.3 SERPINC1 F3 F2 CRP
42 thrombocytosis 29.2 SERPINC1 F3 F2 CRP
43 atrial fibrillation 29.2 SERPINC1 F3 F2 CRP
44 thrombocytopenia 29.2 SERPINC1 F3 F2 CRP
45 carotid artery thrombosis 29.2 SERPINC1 PLG F3
46 budd-chiari syndrome 29.1 SERPINC1 MTHFR F3 F2
47 necrotizing fasciitis 29.1 PLG F3 CRP
48 mitral valve stenosis 29.0 SERPINC1 F3 F2 CRP
49 hemopericardium 29.0 PLG F3 F2
50 purpura 29.0 SERPINC1 F3 F2 CRP

Comorbidity relations with Branch Retinal Artery Occlusion via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Branch Retinal Artery Occlusion:



Diseases related to Branch Retinal Artery Occlusion

Symptoms & Phenotypes for Branch Retinal Artery Occlusion

UMLS symptoms related to Branch Retinal Artery Occlusion:


amaurosis fugax

MGI Mouse Phenotypes related to Branch Retinal Artery Occlusion:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.81 BLOC1S6 CRP F2 F3 MTHFR NPL
2 immune system MP:0005387 9.56 BLOC1S6 CRP F2 F3 NPL PLG
3 reproductive system MP:0005389 9.17 F2 FANCG MTHFR NPL PLG SERPINC1

Drugs & Therapeutics for Branch Retinal Artery Occlusion

Drugs for Branch Retinal Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salicylic acid Approved, Investigational, Vet_approved Phase 3 69-72-7 338
2
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
3
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
4
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
5 Plasminogen Phase 3
6 Tissue Plasminogen Activator Phase 3
7 Analgesics Phase 3
8 Fibrinolytic Agents Phase 3
9 Platelet Aggregation Inhibitors Phase 3
10 Anti-Inflammatory Agents Phase 3
11 Antipyretics Phase 3
12 Analgesics, Non-Narcotic Phase 3
13 Anticoagulants Phase 3
14 Anti-Inflammatory Agents, Non-Steroidal Phase 3
15 Cyclooxygenase Inhibitors Phase 3
16 Antirheumatic Agents Phase 3
17 calcium heparin Phase 3
18 Carbonic Anhydrase Inhibitors Phase 3
19 Natriuretic Agents Phase 3
20 Anticonvulsants Phase 3
21 diuretics Phase 3
22
Adenosine Approved, Investigational Phase 2 58-61-7 60961
23
Regadenoson Approved, Investigational Phase 2 313348-27-5 219024
24
Bevacizumab Approved, Investigational 216974-75-3
25
Brinzolamide Approved 138890-62-7 68844
26 Ophthalmic Solutions
27 Adrenergic Agonists
28 Adrenergic alpha-2 Receptor Agonists
29 Brimonidine Tartrate 70359-46-5

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Topical Timolol for the Treatment of Benign Vascular Periocular Lesions Withdrawn NCT01250457 Phase 4 topical Timolol
2 A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion Recruiting NCT03197194 Phase 3 Alteplase;acetylsalicylic acid;Placebo Oral Tablet;placebo IV
3 Multizenterstudie Der European Assessment Group for Lysis in the Eye (EAGLE) Zur Behandlung Des Zentralarterienverschlusses (ZAV): Lysetherapie Versus Konservative Therapie Terminated NCT00637468 Phase 3 Intravenous injection of heparin;Intravenous injection of acetazolamide;Topical use of beta-blocker;Isovolaemic haemodilution;Acetylsalicylic acid
4 The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform Unknown status NCT00802698 Phase 1, Phase 2
5 The Effect of A2A Adrenoceptor Stimulation on the Diameter of Retinal Arterioles During Hypoxia in Vivo Unknown status NCT03090087 Phase 2 Regadenoson
6 Does Hyperbaric Chamber Improve the Functionality and Symptoms Related to Central Retinal Vein Occlusion (CRVO)? Unknown status NCT02405741 Phase 2
7 Phase 1. Validation and Calibration Phase: Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348633
8 Obstructive Sleep Apnea, Retinal Vein Occlusion, Retinal Artery Occlusion Unknown status NCT01291862
9 Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning Completed NCT02898480
10 Transcorneal Electrical Stimulation Therapy for Retinal Disease - A Randomized, Single-blind Pilot Study Completed NCT00804102
11 Evaluation de la gêne Oculaire après Injections intravitréennes Completed NCT02806830 Optive
12 Hemodynamic Computer-assisted Reconstruction of Pathological Changes at the Origin of the Ophthalmic Artery in Patients With Retinal Artery Occlusion Completed NCT02679716
13 Effect of Fixed Brinzolamide-brimonidine Combination on Intraocular Pressure After Phacoemulsification Completed NCT03494257 Brinzolamide-Brimonidine fixed combination
14 A Pilot Study to Determine the Effect on Intraocular Pressure, Optic Nerve Imaging and Other Markers of Venous Congestion of Volunteer Subjects in the Prone Position for a Period of Five Hours Completed NCT00875043
15 Investigation of Relevant Biomarkers in Patients With Susac Syndrome Recruiting NCT01273792
16 Study of Arterial Recanalization of the Central Retinal Artery Occlusions Recruiting NCT03049514
17 New Non-invasive Modalities for Assessing Retinal Structure and Function:Preliminary Investigation Recruiting NCT03475173
18 Pre and Post-arterial Recanalization Imaging of Central Retinal Artery Occlusions (CRAO) Recruiting NCT03313817
19 Spectral-domain Optical Coherence Tomography Findings in Retinal Vessel Occlusion - A Pilot Study of Detecting Ischemia in OCT Recruiting NCT03061526
20 Evaluation of the Utility of OCT Angiography in Assessing Vascular Perfusion in Rare Retinal and Choroidal Diseases Recruiting NCT02141308
21 Optical Coherence Tomography Angiography Examinations in Chronic Retinal Artery Occlusion Active, not recruiting NCT03357146
22 Prevalence of Ocular Manifestations in Inflammatory Rheumatic Diseases Active, not recruiting NCT03753893
23 Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study Active, not recruiting NCT02390245
24 The Registry of Hyperbaric Oxygen Therapy Treated Patients Enrolling by invitation NCT02483650
25 Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in the Imaging of Retinovascular Disease Terminated NCT01717937
26 The Effect of Table Position on Intraocular Pressure (IOP) and Ocular Perfusion Pressure (OPP) During Prone Spine Surgery Terminated NCT00176722

Search NIH Clinical Center for Branch Retinal Artery Occlusion

Cochrane evidence based reviews: retinal artery occlusion

Genetic Tests for Branch Retinal Artery Occlusion

Anatomical Context for Branch Retinal Artery Occlusion

MalaCards organs/tissues related to Branch Retinal Artery Occlusion:

40
Eye, Heart, Retina, Brain, Thyroid, Bone, Kidney

Publications for Branch Retinal Artery Occlusion

Articles related to Branch Retinal Artery Occlusion:

(show top 50) (show all 1764)
# Title Authors PMID Year
1
Retinal Vascular Signs and Cerebrovascular Diseases. 61
31977663 2020
2
Demonstration of acute retinal ischemia on diffusion weighted magnetic resonance imaging. 61
31816539 2020
3
Symptomatic carotid near-occlusion causes a high risk of recurrent ipsilateral ischemic stroke. 61
31701329 2020
4
Incidence of retinal artery occlusion in Germany. 61
32026572 2020
5
Thrombolytic Therapy for Acute Central Retinal Artery Occlusion. 61
31865896 2020
6
Prevalence of Retinal Emboli and Acute Retinal Artery Occlusion in Acute Ischemic Stroke. 61
31837921 2020
7
Clinical Manifestations and Visual Prognosis of Cilioretinal Artery Sparing Central Retinal Artery Occlusion. 61
32037747 2020
8
Retinal oedema in central retinal artery occlusion develops as a function of time. 61
32040258 2020
9
Comment on: Risk of acute stroke in patients with retinal artery occlusion: a systematic review and meta-analysis. 61
32024973 2020
10
Ocular Manifestations of Sickle Cell Disease: Signs, Symptoms and Complications. 61
32013659 2020
11
Development of visual acuity under hyperbaric oxygen treatment (HBO) in non arteritic retinal branch artery occlusion. 61
31863398 2020
12
Long-Standing Retinal Artery Occlusion: OCT Angiography versus Fluorescein Angiography. 61
31902471 2020
13
Characteristics and Outcomes of Retinal Artery Occlusion: Nationally Representative Data. 61
31951154 2020
14
Branch retinal artery occlusion - Finding the culprit! 61
31856513 2020
15
Distal radial access in the anatomical snuffbox for neurointerventions: a feasibility, safety, and proof-of-concept study. 61
31915209 2020
16
UNILATERAL OPTIC NEURITIS AND CENTRAL RETINAL VASCULITIS DUE TO OCULAR SYPHILIS. 61
28816862 2020
17
Using the Retrobulbar Spot Sign to Assist in Diagnosis and Management of Central Retinal Artery Occlusions. 61
31228289 2020
18
[Central retinal artery occlusion and central retinal vein occlusion after severe contusive trauma: Multimodal imaging]. 61
31987675 2020
19
OPHTHALMIC VASCULAR EVENTS AFTER INTRA-ARTERIAL CHEMOTHERAPY FOR RETINOBLASTOMA: Real-World Comparison Between Primary and Secondary Treatments. 61
30204728 2019
20
Juvenile Central Retinal Artery Occlusion Associated With Atrial Septal Defect. 61
31821511 2019
21
Tick- borne infection revealing human immunodeficiency virus (HIV) positivity in a young adult. 61
31650087 2019
22
Non artheritic bilateral anterior ischaemic optic neuropathy (NAION) as devastating complication following Total Hip Arthroplasty: a case report. 61
31910190 2019
23
Non-invasive current stimulation in vision recovery: a review of the literature. 61
31884495 2019
24
Vision Loss Associated with Hyaluronic Acid Fillers: A Systematic Review of Literature. 61
31822960 2019
25
Prevalence of Atrial Fibrillation in Patients with Retinal Vessel Occlusion and Its Association: A Systematic Review and Meta-Analysis. 61
31283356 2019
26
Bartonella endocarditis masquerading as systemic vasculitis with rapidly progressive glomerulonephritis (aka 'Löhlein nephritis'). 61
31801777 2019
27
Retinal artery occlusion does not portend an increased risk of stroke. 61
31843299 2019
28
Branch retinal artery occlusion in the untreated contralateral eye following aflibercept injections during heparin treatment: Possible contribution of a heparin-induced thrombocytopenia-like condition. 61
31508535 2019
29
Central retinal artery occlusion in a child with angiolymphoid hyperplasia with eosinophilia orbit. 61
31755456 2019
30
Effect of vitrectomy with intrasurgical regulation of intraocular pressure in a rabbit model of central retinal artery occlusion. 61
31626799 2019
31
Idiopathic central retinal artery occlusion. 61
31693152 2019
32
Symptomatic Retinal Artery Occlusion after Angioplasty and Stenting of the Carotid Artery: Incidence and Related Risk Factors. 61
31606959 2019
33
Delayed branch retinal artery occlusion in infectious endocarditis. 61
31685405 2019
34
Risk of acute stroke in patients with retinal artery occlusion. 61
31767959 2019
35
Non-arteritic anterior ischemic optic neuropathy with Cilioretinal artery occlusion: a case report. 61
31726996 2019
36
Histopathology of retinoblastoma eyes enucleated after intra-arterial chemotherapy. 61
31676593 2019
37
Association of Retinal Artery Occlusion with Subclinical Coronary Artery Disease. 61
31726494 2019
38
Hypothermia protects retinal ganglion cells against hypoxia-induced cell death in a retina organ culture model. 61
31152487 2019
39
Retinal Artery and Vein Occlusions Successfully Treated with Hyperbaric Oxygen. 61
31763582 2019
40
Susac Syndrome: A Rare Case Report. 61
31599263 2019
41
[Central retinal artery occlusion secondary to pheochromocytoma]. 61
31182254 2019
42
Spontaneous Intra-orbital Arteriovenous Fistula: A Rare Cause of Proptosis. 61
31807372 2019
43
Retinal artery occlusion is associated with compositional and functional shifts in the gut microbiome and altered trimethylamine-N-oxide levels. 61
31653902 2019
44
[Reduced Caliber of the Ophthalmic Artery in Magnetic Resonance Angiography in Patients after Retinal Artery Occlusion]. 61
31652483 2019
45
Ophthalmic and Central Retinal Artery Occlusion Following Triamcinolone Injection of the Lacrimal Gland. 61
31600385 2019
46
Arteritic Orbital Ischemia Producing Afferent and Efferent Pupillary Defects. 61
31524841 2019
47
[Eye involvement in large vesssel vasculitis (giant cell arteritis and Takayasu's arteritis)]. 61
31463637 2019
48
Acute blindness as a presenting sign of left atrial myxoma in a pediatric patient: A case report and literature review. 61
31567993 2019
49
Branch retinal artery occlusion with embolic movements. 61
31436199 2019
50
Bilateral methamphetamine-induced ischemic retinopathy. 61
31194074 2019

Variations for Branch Retinal Artery Occlusion

Expression for Branch Retinal Artery Occlusion

Search GEO for disease gene expression data for Branch Retinal Artery Occlusion.

Pathways for Branch Retinal Artery Occlusion

GO Terms for Branch Retinal Artery Occlusion

Cellular components related to Branch Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 VEGFA SERPINC1 PLG F3 F2 CRP
2 blood microparticle GO:0072562 9.13 SERPINC1 PLG F2
3 collagen-containing extracellular matrix GO:0062023 8.92 SERPINC1 PLG F3 F2

Biological processes related to Branch Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibrinolysis GO:0042730 9.4 PLG F2
2 positive regulation of positive chemotaxis GO:0050927 9.37 VEGFA F3
3 blood coagulation GO:0007596 9.35 SERPINC1 PLG F3 F2 BLOC1S6
4 regulation of blood coagulation GO:0030193 9.32 SERPINC1 F2
5 negative regulation of fibrinolysis GO:0051918 9.26 PLG F2
6 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.16 VEGFA PLG
7 hemostasis GO:0007599 8.92 SERPINC1 PLG F3 F2

Molecular functions related to Branch Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.13 VEGFA SERPINC1 F2
2 serine-type endopeptidase activity GO:0004252 8.8 PLG F3 F2

Sources for Branch Retinal Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....