MCID: BRN026
MIFTS: 41

Branch Retinal Artery Occlusion

Categories: Cardiovascular diseases, Eye diseases

Aliases & Classifications for Branch Retinal Artery Occlusion

MalaCards integrated aliases for Branch Retinal Artery Occlusion:

Name: Branch Retinal Artery Occlusion 12 15 72
Retinal Artery Occlusion 44 72
Arterial Retinal Branch Occlusion 12
Retinal Arterial Branch Occlusion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13094
ICD9CM 35 362.32
MeSH 44 D015356
NCIt 50 C34436
SNOMED-CT 68 50821009
ICD10 33 H34.23
UMLS 72 C0006123 C0035302

Summaries for Branch Retinal Artery Occlusion

MalaCards based summary : Branch Retinal Artery Occlusion, also known as retinal artery occlusion, is related to retinal vascular occlusion and retinal artery occlusion, and has symptoms including amaurosis fugax An important gene associated with Branch Retinal Artery Occlusion is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways is Complement and coagulation cascades. The drugs Salicylic acid and Heparin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related phenotype is mortality/aging.

Related Diseases for Branch Retinal Artery Occlusion

Diseases related to Branch Retinal Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 407)
# Related Disease Score Top Affiliating Genes
1 retinal vascular occlusion 32.9 SERPINC1 MTHFR FANCG F2 APOH
2 retinal artery occlusion 32.1 SERPINC1 MTHFR F2 APOH
3 retinal vein occlusion 31.2 SERPINC1 MTHFR F2 APOH
4 homocysteinemia 31.1 SERPINC1 MTHFR F2
5 nonarteritic anterior ischemic optic neuropathy 31.0 SERPINC1 MTHFR F2
6 central retinal vein occlusion 30.9 SERPINC1 MTHFR F2 APOH
7 endocarditis 30.8 SERPINC1 F2 APOH
8 patent foramen ovale 30.7 SERPINC1 MTHFR F2 APOH
9 arteritic anterior ischemic optic neuropathy 30.6 MTHFR FANCG F2
10 sneddon syndrome 30.5 SERPINC1 F2 APOH
11 eclampsia 30.5 SERPINC1 MTHFR F2
12 thrombocytosis 30.4 SERPINC1 F3 F2
13 buerger disease 30.3 MTHFR F2 APOH
14 catastrophic antiphospholipid syndrome 30.3 MTHFR F3 CD40LG APOH
15 papilledema 30.2 F2 APOH
16 arteries, anomalies of 30.2 WDTC1 SERPINC1 LPA F3
17 thrombophilia 30.2 SERPINC1 MTHFR F3 F2 APOH
18 livedoid vasculitis 30.1 SERPINC1 MTHFR F2 APOH
19 thrombophlebitis 30.1 SERPINC1 MTHFR F2 APOH
20 portal vein thrombosis 30.1 SERPINC1 MTHFR F2 APOH
21 protein s deficiency 30.0 SERPINC1 MTHFR F3 F2 APOH
22 thrombophilia due to activated protein c resistance 30.0 SERPINC1 MTHFR F3 F2 APOH
23 thrombophilia due to thrombin defect 30.0 SERPINC1 MTHFR F3 F2 APOH
24 thrombosis 29.9 SERPINC1 MTHFR F3 F2 APOH
25 purpura 29.9 SERPINC1 F3 F2 APOH
26 antiphospholipid syndrome 29.9 SERPINC1 MTHFR F3 F2 CD40LG APOH
27 peripheral vascular disease 29.8 SERPINC1 LPA F3 F2
28 budd-chiari syndrome 29.7 SERPINC1 MTHFR F3 F2 APOH
29 stroke, ischemic 29.6 SERPINC1 MTHFR LPA F3 F2 APOH
30 vascular disease 29.4 SERPINC1 MTHFR LPA F3 F2 APOH
31 acute myocardial infarction 29.2 SERPINC1 MHRT F3
32 myocardial infarction 29.0 SERPINC1 MTHFR LPA F3 F2 CD40LG
33 transient retinal arterial occlusion 12.6
34 partial arterial retinal occlusion 11.9
35 retinal ischemia 11.9
36 prothrombin deficiency 10.6 F3 F2
37 neuroretinitis 10.5
38 mesenteric vascular occlusion 10.5 MTHFR F2
39 central retinal artery occlusion 10.5
40 scotoma 10.5
41 intracranial embolism 10.5 SERPINC1 F2
42 alpha-2-plasmin inhibitor deficiency 10.5 SERPINC1 F2
43 retinal vascular disease 10.5
44 vasculitis 10.5
45 ischemic neuropathy 10.5 MTHFR F2
46 cerebral falx meningioma 10.4 F3 F2
47 carotid stenosis 10.4
48 cryptogenic cirrhosis 10.4 MTHFR F2
49 heparin-induced thrombocytopenia 10.4 SERPINC1 F3 CD40LG
50 erythema infectiosum 10.4 CD40LG APOH

Comorbidity relations with Branch Retinal Artery Occlusion via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Branch Retinal Artery Occlusion:



Diseases related to Branch Retinal Artery Occlusion

Symptoms & Phenotypes for Branch Retinal Artery Occlusion

UMLS symptoms related to Branch Retinal Artery Occlusion:


amaurosis fugax

MGI Mouse Phenotypes related to Branch Retinal Artery Occlusion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.4 APOH CD40LG F2 F3 FOXO4 MTHFR

Drugs & Therapeutics for Branch Retinal Artery Occlusion

Drugs for Branch Retinal Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salicylic acid Approved, Investigational, Vet_approved Phase 3 69-72-7 338
2
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
3
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
4
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
5 Tissue Plasminogen Activator Phase 3
6 Plasminogen Phase 3
7 Analgesics Phase 3
8 Anti-Inflammatory Agents Phase 3
9 Cyclooxygenase Inhibitors Phase 3
10 Fibrinolytic Agents Phase 3
11 Natriuretic Agents Phase 3
12 Analgesics, Non-Narcotic Phase 3
13 Peripheral Nervous System Agents Phase 3
14 diuretics Phase 3
15 Platelet Aggregation Inhibitors Phase 3
16 Anticonvulsants Phase 3
17 calcium heparin Phase 3
18 Anticoagulants Phase 3
19 Anti-Inflammatory Agents, Non-Steroidal Phase 3
20 Antipyretics Phase 3
21 Antirheumatic Agents Phase 3
22 Carbonic Anhydrase Inhibitors Phase 3
23
Regadenoson Approved, Investigational Phase 2 313348-27-5 219024
24
Adenosine Approved, Investigational Phase 2 58-61-7 60961
25 Purinergic P1 Receptor Agonists Phase 2
26
Bevacizumab Approved, Investigational 216974-75-3
27
Brinzolamide Approved 138890-62-7 68844
28 Ophthalmic Solutions
29 Adrenergic Agonists
30 Adrenergic alpha-2 Receptor Agonists
31 Adrenergic alpha-Agonists
32 Brimonidine Tartrate 70359-46-5

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Topical Timolol for the Treatment of Benign Vascular Periocular Lesions Withdrawn NCT01250457 Phase 4 topical Timolol
2 A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion Recruiting NCT03197194 Phase 3 Alteplase;acetylsalicylic acid;Placebo Oral Tablet;placebo IV
3 Multizenterstudie Der European Assessment Group for Lysis in the Eye (EAGLE) Zur Behandlung Des Zentralarterienverschlusses (ZAV): Lysetherapie Versus Konservative Therapie Terminated NCT00637468 Phase 3 Intravenous injection of heparin;Intravenous injection of acetazolamide;Topical use of beta-blocker;Isovolaemic haemodilution;Acetylsalicylic acid
4 The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform Unknown status NCT00802698 Phase 1, Phase 2
5 Does Hyperbaric Chamber Improve the Functionality and Symptoms Related to Central Retinal Vein Occlusion (CRVO)? Unknown status NCT02405741 Phase 2
6 The Effect of A2A Adrenoceptor Stimulation on the Diameter of Retinal Arterioles During Hypoxia in Vivo Unknown status NCT03090087 Phase 2 Regadenoson
7 Phase 1. Validation and Calibration Phase: Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348633
8 Obstructive Sleep Apnea, Retinal Vein Occlusion, Retinal Artery Occlusion Unknown status NCT01291862
9 Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning Completed NCT02898480
10 Transcorneal Electrical Stimulation Therapy for Retinal Disease - A Randomized, Single-blind Pilot Study Completed NCT00804102
11 Evaluation de la gêne Oculaire après Injections intravitréennes Completed NCT02806830 Optive
12 Hemodynamic Computer-assisted Reconstruction of Pathological Changes at the Origin of the Ophthalmic Artery in Patients With Retinal Artery Occlusion Completed NCT02679716
13 A Pilot Study to Determine the Effect on Intraocular Pressure, Optic Nerve Imaging and Other Markers of Venous Congestion of Volunteer Subjects in the Prone Position for a Period of Five Hours Completed NCT00875043
14 Effect of Fixed Brinzolamide-brimonidine Combination on Intraocular Pressure After Phacoemulsification Completed NCT03494257 Brinzolamide-Brimonidine fixed combination
15 Investigation of Relevant Biomarkers in Patients With Susac Syndrome Recruiting NCT01273792
16 Study of Arterial Recanalization of the Central Retinal Artery Occlusions Recruiting NCT03049514
17 New Non-invasive Modalities for Assessing Retinal Structure and Function:Preliminary Investigation Recruiting NCT03475173
18 Pre and Post-arterial Recanalization Imaging of Central Retinal Artery Occlusions (CRAO) Recruiting NCT03313817
19 Spectral-domain Optical Coherence Tomography Findings in Retinal Vessel Occlusion - A Pilot Study of Detecting Ischemia in OCT Recruiting NCT03061526
20 Evaluation of the Utility of OCT Angiography in Assessing Vascular Perfusion in Rare Retinal and Choroidal Diseases Recruiting NCT02141308
21 Epidemiological, Clinical and Etiological Features of SUSAC's Syndrome (RETINOCOCHLEOCEREBRAL Vasculopathy) Recruiting NCT01481662
22 Optical Coherence Tomography Angiography Examinations in Chronic Retinal Artery Occlusion Active, not recruiting NCT03357146
23 Prevalence of Ocular Manifestations in Inflammatory Rheumatic Diseases Active, not recruiting NCT03753893
24 Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study Active, not recruiting NCT02390245
25 The Registry of Hyperbaric Oxygen Therapy Treated Patients Enrolling by invitation NCT02483650
26 Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in the Imaging of Retinovascular Disease Terminated NCT01717937
27 The Effect of Table Position on Intraocular Pressure (IOP) and Ocular Perfusion Pressure (OPP) During Prone Spine Surgery Terminated NCT00176722

Search NIH Clinical Center for Branch Retinal Artery Occlusion

Cochrane evidence based reviews: retinal artery occlusion

Genetic Tests for Branch Retinal Artery Occlusion

Anatomical Context for Branch Retinal Artery Occlusion

MalaCards organs/tissues related to Branch Retinal Artery Occlusion:

41
Eye, Retina, Brain, Heart, Thyroid, Endothelial, Bone

Publications for Branch Retinal Artery Occlusion

Articles related to Branch Retinal Artery Occlusion:

(show top 50) (show all 1703)
# Title Authors PMID Year
1
Branch retinal artery occlusion with embolic movements. 38
31436199 2019
2
Bilateral methamphetamine-induced ischemic retinopathy. 38
31194074 2019
3
Incidence of retinal artery occlusion following intravitreal antivascular endothelial growth factor injections. 38
30810272 2019
4
A middle hyper-reflective band on spectral domain optical coherence tomography in a case of acute nonarteritic central retinal artery occlusion with sparing of cilioretinal artery. 38
31332136 2019
5
Takayasu's arteritis: a unique ophthalmic presentation with CRAO and BRVO. 38
31420422 2019
6
Central retinal artery occlusion after Descemet membrane reposition by intracameral air: A case report. 38
31432690 2019
7
Central Retinal Artery Occlusion Associated with Carotid Artery Occlusion. 38
31403098 2019
8
Known and novel ocular toxicities of biologics, targeted agents, and traditional chemotherapeutics. 38
31098752 2019
9
Assessing Retrobulbar Hyaluronidase as a Treatment for Filler-Induced Blindness in a Cadaver Model. 38
31348334 2019
10
Clinical Observations and the Anatomical Basis of Blindness After Facial Hyaluronic Acid Injection. 38
31006827 2019
11
Susac Syndrome: Clinical characteristics, diagnostic findings and treatment in 19 cases. 38
31176296 2019
12
Occlusion of the central retinal artery in Plasmodium falciparum malaria. 38
31350230 2019
13
Effectiveness of Retrobulbar Hyaluronidase Injection in an Iatrogenic Blindness Rabbit Model Using Hyaluronic Acid Filler Injection. 38
31246817 2019
14
Direct carotid puncture for endovascular thrombectomy in acute ischemic stroke. 38
30954938 2019
15
A review and update on the ophthalmic implications of Susac syndrome. 38
30703404 2019
16
Prevalence of Atrial Fibrillation in Patients with Retinal Vessel Occlusion and Its Association: A Systematic Review and Meta-Analysis. 38
31283356 2019
17
Central retinal artery occlusion-A new, provisional treatment approach. 38
30707925 2019
18
Preferred practice pattern for central retinal artery occlusion management. 38
30946807 2019
19
[Spontaneous visual recovery following a central retinal artery occlusion in a patient with a cilioretinal artery]. 38
31303015 2019
20
CASE SERIES OF HYPERBARIC OXYGEN THERAPY FOR CENTRAL RETINAL ARTERY OCCLUSION. 38
31306292 2019
21
Hypothermia protects retinal ganglion cells against hypoxia-induced cell death in a retina organ culture model. 38
31152487 2019
22
Coexistent central retinal vein and artery occlusion in a patient with psoriasis receiving ustekinumab. 38
30502969 2019
23
Iatrogenic retinal central artery occlusion after a cerebral digital subtraction angiography. 38
30770151 2019
24
[Central retinal artery occlusion of the right eye with bifid cilioretinal artery]. 38
31104876 2019
25
A novel strategy for quantification of panoramic en face optical coherence tomography angiography scan field. 38
30972485 2019
26
Contemporary prevalence of carotid stenosis in patients presenting with ischaemic stroke. 38
30938840 2019
27
Visualization of a retinal embolus associated with branch retinal artery occlusion with OCT-angiography. 38
31097314 2019
28
Occurrence of Hemi-Central Retinal Artery Occlusion Following Embolization in a Case of Recurrent Juvenile Nasopharyngeal Angiofibroma. 38
31233156 2019
29
Neuropathological Findings in Susac Syndrome: An Autopsy Report. 38
31100145 2019
30
Neurofibromatosis Type 1 Vasculopathy Presenting as Impending Central Retinal Artery Occlusion. 38
30540635 2019
31
[Central retinal artery occlusion secondary to pheochromocytoma]. 38
31182254 2019
32
Using the Retrobulbar Spot Sign to Assist in Diagnosis and Management of Central Retinal Artery Occlusions. 38
31228289 2019
33
Central retinal artery occlusion as an onset form of Takayasu's arteritis. 38
30424934 2019
34
The Effects of Hyperbaric Oxygen at Different Pressures on Oxidative Stress and Antioxidant Status in Rats. 38
31137620 2019
35
Ocular ischaemia due to a spontaneous carotid artery dissection. 38
31061190 2019
36
CRAO in Moyamoya Syndrome Associated With Southampton Hemoglobinopathy. 38
31100171 2019
37
A rare complication of endoscopic sinus surgery: Retinal artery occlusion. 38
30203670 2019
38
Intravenous Prostaglandin E1 Infusion for Acute Central Retinal Artery Occlusion. 38
31100175 2019
39
Transient Retinal Artery Occlusion After Uncomplicated Rhinoplasty. 38
30730513 2019
40
Stroke Risk and Risk Factors in Patients With Central Retinal Artery Occlusion. 38
30827486 2019
41
Stroke Risk and Risk Factors in Patients With Central Retinal Artery Occlusion. 38
30935476 2019
42
Bartonella presenting as branch retinal artery occlusion in a child. 38
30710644 2019
43
Acute Vascular Ischemic Events in Patients With Central Retinal Artery Occlusion in the United States: A Nationwide Study 2003-2014. 38
30689989 2019
44
BLIND-SIDED BY COSMETIC VEIN SCLEROTHERAPY: A CASE OF OPHTHALMIC ARTERIAL OCCLUSION. 38
28267111 2019
45
A 23-Year-Old Woman with Sudden-Onset Blindness of the Right Eye. 38
30638937 2019
46
"Effectiveness of retrobulbar hyaluronidase injection in an iatrogenic blindness rabbit model using hyaluronic acid filler injection". 38
31008917 2019
47
Sudden-onset Blindness from a Spontaneous Carotid-cavernous Fistula with Secondary Central Retinal Artery Occlusion and Posterior Ischemic Optic Neuropathy. 38
31312235 2019
48
RETINAL ARTERY OCCLUSION AFTER INTRAVASCULAR PROCEDURES: Case Series and Literature Review. 38
29266046 2019
49
Stroke Risk and Risk Factors in Patients With Central Retinal Artery Occlusion. 38
30579615 2019
50
Mesenchymal stem cell-derived extracellular vesicles and retinal ischemia-reperfusion. 38
30654160 2019

Variations for Branch Retinal Artery Occlusion

Expression for Branch Retinal Artery Occlusion

Search GEO for disease gene expression data for Branch Retinal Artery Occlusion.

Pathways for Branch Retinal Artery Occlusion

Pathways related to Branch Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.94 SERPINC1 F3 F2

GO Terms for Branch Retinal Artery Occlusion

Biological processes related to Branch Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation, intrinsic pathway GO:0007597 9.32 F2 APOH
2 positive regulation of blood coagulation GO:0030194 9.26 F2 APOH
3 negative regulation of fibrinolysis GO:0051918 9.16 F2 APOH
4 hemostasis GO:0007599 9.13 SERPINC1 F3 F2
5 regulation of blood coagulation GO:0030193 8.8 SERPINC1 F2 APOH

Molecular functions related to Branch Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.13 PSD F3 APOH
2 heparin binding GO:0008201 8.92 SERPINC1 LPA F2 APOH
3 protein binding GO:0005515 10.06 WDTC1 TPT1 TBCE SERPINC1 PSD PRDM10

Sources for Branch Retinal Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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