MCID: BRN026
MIFTS: 40

Branch Retinal Artery Occlusion

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Branch Retinal Artery Occlusion

MalaCards integrated aliases for Branch Retinal Artery Occlusion:

Name: Branch Retinal Artery Occlusion 12 15 71
Retinal Artery Occlusion 43 71
Arterial Retinal Branch Occlusion 12
Retinal Arterial Branch Occlusion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13094
ICD9CM 34 362.32
MeSH 43 D015356
NCIt 49 C34436
SNOMED-CT 67 50821009
ICD10 32 H34.23
UMLS 71 C0006123 C0035302

Summaries for Branch Retinal Artery Occlusion

MalaCards based summary : Branch Retinal Artery Occlusion, also known as retinal artery occlusion, is related to macular retinal edema and carotid stenosis, and has symptoms including amaurosis fugax An important gene associated with Branch Retinal Artery Occlusion is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Salicylic acid and Heparin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain.

Related Diseases for Branch Retinal Artery Occlusion

Diseases related to Branch Retinal Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 503)
# Related Disease Score Top Affiliating Genes
1 macular retinal edema 30.8 VEGFA FANCG CRYAA
2 carotid stenosis 30.8 VEGFA MTHFR CRP
3 orbital cellulitis 30.8 CRYAA CRP
4 retinal vein occlusion 30.7 VEGFA SERPINC1 MTHFR F2
5 arteritic anterior ischemic optic neuropathy 30.6 MTHFR F2
6 posterior scleritis 30.5 FANCG CRP
7 scotoma 30.5 VEGFA AQP4
8 optic papillitis 30.5 CRP AQP4
9 thrombophilia 30.4 SERPINC1 MTHFR F2
10 homocysteinemia 30.4 SERPINC1 MTHFR F2 CRP
11 intraocular pressure quantitative trait locus 30.3 VEGFA CRYAA AQP4
12 homocystinuria 30.3 SERPINC1 MTHFR CRYAA
13 sneddon syndrome 30.3 SERPINC1 F2
14 prothrombin-related thrombophilia 30.3 MTHFR F2
15 protein s deficiency 30.2 SERPINC1 MTHFR F2
16 neovascular glaucoma 30.2 VEGFA PLG CRYAA
17 thrombophilia due to thrombin defect 30.2 SERPINC1 MTHFR F2
18 antiphospholipid syndrome 30.1 SERPINC1 MTHFR F2 CRP
19 exanthem 30.1 VEGFA F2 CRP
20 central nervous system vasculitis 30.1 CRP BLOC1S6
21 endocarditis 30.1 SERPINC1 F2 CRP
22 cavernous sinus thrombosis 30.1 SERPINC1 F2 CRP
23 iridocyclitis 30.1 VEGFA CRP
24 intracranial hypertension, idiopathic 30.1 F2 AQP4
25 takayasu arteritis 30.0 SERPINC1 F2 CRP
26 thrombocytosis 30.0 SERPINC1 F2 CRP
27 cavernous hemangioma 30.0 VEGFA SERPINC1 F2
28 atherosclerosis susceptibility 30.0 VEGFA MTHFR CRP
29 cranial nerve palsy 30.0 CRP AQP4
30 budd-chiari syndrome 29.9 SERPINC1 MTHFR F2
31 microvascular complications of diabetes 5 29.9 VEGFA PLG CRYAA
32 buerger disease 29.9 MTHFR F2
33 mitral valve stenosis 29.8 SERPINC1 F2 CRP
34 vitreous detachment 29.8 VEGFA PLG
35 sickle cell anemia 29.8 MTHFR F2 CRP
36 purpura 29.8 SERPINC1 F2 CRP
37 meningitis 29.8 VEGFA CRP AQP4
38 arteries, anomalies of 29.7 VEGFA PLG CRP
39 pericardial effusion 29.7 VEGFA F2 CRP
40 retinal vascular disease 29.7 VEGFA PLG MTHFR CRYAA CRP
41 hemopericardium 29.6 PLG F2
42 macular holes 29.6 VEGFA PLG CRYAA
43 rubeosis iridis 29.6 VEGFA PLG FANCG
44 portal vein thrombosis 29.6 SERPINC1 MTHFR F2 CRP
45 central retinal vein occlusion 29.5 VEGFA SERPINC1 PLG MTHFR F2
46 eclampsia 29.5 VEGFA SERPINC1 MTHFR F2
47 papilledema 29.4 VEGFA SERPINC1 F2 CRP
48 intracranial hypertension 29.4 SERPINC1 MTHFR F2 AQP4
49 kuhnt-junius degeneration 29.4 VEGFA PLG CRYAA
50 essential thrombocythemia 29.3 VEGFA SERPINC1 MTHFR F2 CRP

Comorbidity relations with Branch Retinal Artery Occlusion via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Branch Retinal Artery Occlusion:



Diseases related to Branch Retinal Artery Occlusion

Symptoms & Phenotypes for Branch Retinal Artery Occlusion

UMLS symptoms related to Branch Retinal Artery Occlusion:


amaurosis fugax

Drugs & Therapeutics for Branch Retinal Artery Occlusion

Drugs for Branch Retinal Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salicylic acid Approved, Investigational, Vet_approved Phase 3 69-72-7 338
2
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
3
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
4
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
5 Tissue Plasminogen Activator Phase 3
6 Plasminogen Phase 3
7 Fibrinolytic Agents Phase 3
8 Analgesics, Non-Narcotic Phase 3
9 diuretics Phase 3
10 Analgesics Phase 3
11 Cyclooxygenase Inhibitors Phase 3
12 Platelet Aggregation Inhibitors Phase 3
13 Anti-Inflammatory Agents Phase 3
14 Anticonvulsants Phase 3
15 Antipyretics Phase 3
16 Antirheumatic Agents Phase 3
17 Carbonic Anhydrase Inhibitors Phase 3
18 calcium heparin Phase 3
19 Anti-Inflammatory Agents, Non-Steroidal Phase 3
20 Anticoagulants Phase 3
21
Regadenoson Approved, Investigational Phase 2 313348-27-5 219024
22
Adenosine Approved, Investigational Phase 2 58-61-7 60961
23
Bevacizumab Approved, Investigational 216974-75-3
24
Brinzolamide Approved 138890-62-7 68844
25 Ophthalmic Solutions
26 Adrenergic alpha-Agonists
27 Adrenergic Agonists
28 Brimonidine Tartrate 70359-46-5

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Topical Timolol for the Treatment of Benign Vascular Periocular Lesions Withdrawn NCT01250457 Phase 4 topical Timolol
2 A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion Recruiting NCT03197194 Phase 3 Alteplase;acetylsalicylic acid;Placebo Oral Tablet;placebo IV
3 Multizenterstudie Der European Assessment Group for Lysis in the Eye (EAGLE) Zur Behandlung Des Zentralarterienverschlusses (ZAV): Lysetherapie Versus Konservative Therapie Terminated NCT00637468 Phase 3 Intravenous injection of heparin;Intravenous injection of acetazolamide;Topical use of beta-blocker;Isovolaemic haemodilution;Acetylsalicylic acid
4 The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform Unknown status NCT00802698 Phase 1, Phase 2
5 Does Hyperbaric Chamber Improve the Functionality and Symptoms Related to Central Retinal Vein Occlusion (CRVO)? Unknown status NCT02405741 Phase 2
6 The Effect of A2A Adrenoceptor Stimulation on the Diameter of Retinal Arterioles During Hypoxia in Vivo Unknown status NCT03090087 Phase 2 Regadenoson
7 Phase 1. Validation and Calibration Phase: Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348633
8 Obstructive Sleep Apnea, Retinal Vein Occlusion, Retinal Artery Occlusion Unknown status NCT01291862
9 The Registry of Hyperbaric Oxygen Therapy Treated Patients Unknown status NCT02483650
10 Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning Completed NCT02898480
11 Transcorneal Electrical Stimulation Therapy for Retinal Disease - A Randomized, Single-blind Pilot Study Completed NCT00804102
12 Evaluation de la gêne Oculaire après Injections intravitréennes Completed NCT02806830 Optive
13 Hemodynamic Computer-assisted Reconstruction of Pathological Changes at the Origin of the Ophthalmic Artery in Patients With Retinal Artery Occlusion Completed NCT02679716
14 Effect of Fixed Brinzolamide-brimonidine Combination on Intraocular Pressure After Phacoemulsification Completed NCT03494257 Brinzolamide-Brimonidine fixed combination
15 A Pilot Study to Determine the Effect on Intraocular Pressure, Optic Nerve Imaging and Other Markers of Venous Congestion of Volunteer Subjects in the Prone Position for a Period of Five Hours Completed NCT00875043
16 Investigation of Relevant Biomarkers in Patients With Susac Syndrome Recruiting NCT01273792
17 Study of Arterial Recanalization of the Central Retinal Artery Occlusions Recruiting NCT03049514
18 New Non-invasive Modalities for Assessing Retinal Structure and Function:Preliminary Investigation Recruiting NCT03475173
19 Pre and Post-arterial Recanalization Imaging of Central Retinal Artery Occlusions (CRAO) Recruiting NCT03313817
20 Spectral-domain Optical Coherence Tomography Findings in Retinal Vessel Occlusion - A Pilot Study of Detecting Ischemia in OCT Recruiting NCT03061526
21 Evaluation of the Utility of OCT Angiography in Assessing Vascular Perfusion in Rare Retinal and Choroidal Diseases Recruiting NCT02141308
22 Optical Coherence Tomography Angiography Examinations in Chronic Retinal Artery Occlusion Active, not recruiting NCT03357146
23 Prevalence of Ocular Manifestations in Inflammatory Rheumatic Diseases Active, not recruiting NCT03753893
24 Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study Active, not recruiting NCT02390245
25 Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in the Imaging of Retinovascular Disease Terminated NCT01717937
26 The Effect of Table Position on Intraocular Pressure (IOP) and Ocular Perfusion Pressure (OPP) During Prone Spine Surgery Terminated NCT00176722

Search NIH Clinical Center for Branch Retinal Artery Occlusion

Cochrane evidence based reviews: retinal artery occlusion

Genetic Tests for Branch Retinal Artery Occlusion

Anatomical Context for Branch Retinal Artery Occlusion

MalaCards organs/tissues related to Branch Retinal Artery Occlusion:

40
Eye, Retina, Brain, Heart, Thyroid, Endothelial, Neutrophil

Publications for Branch Retinal Artery Occlusion

Articles related to Branch Retinal Artery Occlusion:

(show top 50) (show all 1818)
# Title Authors PMID Year
1
Circumpapillary collateral vessel development in iatrogenic central retinal artery occlusion observed using OCT angiography. 61
32490281 2020
2
Branch retinal artery occlusion secondary to Bartonella henselae infection in a 13 year-old. 61
32435719 2020
3
Ocular Manifestations of Sickle Cell Disease: Signs, Symptoms and Complications. 61
32013659 2020
4
Retinal artery occlusion does not portend an increased risk of stroke. 61
31843299 2020
5
Intravenous Fibrinolysis for Central Retinal Artery Occlusion: A Cohort Study and Updated Patient-Level Meta-Analysis. 61
32568646 2020
6
Normal to supernormal 30-Hz flicker ERGs predict visual function and prognosis in central retinal artery occlusion. 61
32506269 2020
7
A case of disseminated microscopic demyelination with multifocal dystrophic calcification. 61
32128889 2020
8
Atrial fibrillation post central retinal artery occlusion:role of implantable loop recorders. 61
32567072 2020
9
ACUTE RETINAL ISCHEMIA IN CENTRAL VERSUS BRANCH RETINAL ARTERY OCCLUSION: Changes in Retinal Layers' Thickness on Spectral-Domain Optical Coherence Tomography in Different Grades of Retinal Ischemia. 61
30908470 2020
10
[Successful Systemic Lysis Therapy in Acute Retinal Arterial Occlusions]. 61
32092776 2020
11
Retinal artery occlusion followed by contralateral amaurosis fugax in association with eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). 61
32309675 2020
12
Vision Loss Associated with Hyaluronic Acid Fillers: A Systematic Review of Literature. 61
31822960 2020
13
Risk of acute stroke in patients with retinal artery occlusion. 61
31767959 2020
14
Antithrombotic Therapy in Hereditary Hemorrhagic Telangiectasia: Real-World Data from the Gemelli Hospital HHT Registry. 61
32498318 2020
15
Central retinal artery occlusion as initial presentation of Moyamoya disease in a middle-aged woman. 61
32322754 2020
16
[Multimodal imaging of combined central retinal artery occlusion and central retinal vein occlusion secondary to Behçet's disease]. 61
32362403 2020
17
Essential thrombocythemia manifesting as ophthalmic artery occlusion. 61
32373760 2020
18
Retinal artery occlusion after herpes zoster mandibularis in a patient with systemic lupus erythematosus. 61
30599475 2020
19
Ophthalmic Emergencies for the Clinician. 61
32370836 2020
20
Autophagy and post-ischemic conditioning in retinal ischemia. 61
32452260 2020
21
Rituximab in the treatment of Susac's syndrome: Report of a case. 61
32380850 2020
22
Bilateral branch retinal artery occlusion in a child with nephrotic syndrome. 61
32385124 2020
23
HYPERACUTE RETINAL ARTERIAL WALL DYMANICS IN EMBOLIC PARACENTRAL ACUTE MIDDLE MACULOPATHY. 61
32407926 2020
24
Response by Mac Grory et al to Letter Regarding Article, "Thrombolytic Therapy for Acute Central Retinal Artery Occlusion". 61
32299321 2020
25
Letter by Nicholson et al Regarding Article, "Thrombolytic Therapy for Acute Central Retinal Artery Occlusion". 61
32299323 2020
26
Central Retinal Artery Occlusion Following Prone Transcranial Surgery for Craniosynostosis and Discussion of Risk Factors. 61
32398620 2020
27
Novel Application of Point-of-Care Ocular Ultrasound in a Left Central Retinal Artery Occlusion. 61
32377466 2020
28
Window to the circulatory system: Ocular manifestations of cardiovascular diseases. 61
32340480 2020
29
Risk of acute stroke in patients with retinal artery occlusion: a systematic review and meta-analysis. 61
31527762 2020
30
Prepapillary vascular loop-a new classification. 61
32291404 2020
31
Training in and comfort with diagnosis and management of ophthalmic emergencies among emergency medicine physicians in the United States. 61
32350451 2020
32
[Retinal artery occlusion and anterior ischemic optic neuropathy associated with factor V Leiden mutation: A case report]. 61
32107025 2020
33
Characteristics and outcomes of patients with ophthalmologic involvement in giant-cell arteritis: A case-control study. 61
32192630 2020
34
[Double cilioretinal arteries in a patient with central retinal artery occlusion]. 61
32122669 2020
35
Retrobulbar Spot Sign in Metachronous Bilateral Central Retinal Artery Occlusion of Cardioembolic Origin. 61
32282511 2020
36
Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in Patients with Retinal Artery Occlusion. 61
32308954 2020
37
Dramatic recovery of vision in patient with acute central retinal artery occlusion treated with local intra-arterial tissue plasminogen activator. 61
32300037 2020
38
The M.A.STE.R.S algorithm for acute visual loss management after facial filler injection. 61
32270627 2020
39
Iatrogenic ophthalmic artery occlusion and retinal artery occlusion. 61
32165219 2020
40
Anomalous retinal artery associated with branch retinal artery occlusion and neovascular glaucoma: A case report. 61
32190636 2020
41
Retinal Vascular Signs and Cerebrovascular Diseases. 61
31977663 2020
42
Idiopathic central retinal artery occlusion. 61
31693152 2020
43
Characteristics and Outcomes of Retinal Artery Occlusion: Nationally Representative Data. 61
31951154 2020
44
Ocular complications of cat scratch disease. 61
32122915 2020
45
[Central retinal artery occlusion and central retinal vein occlusion after severe contusive trauma: Multimodal imaging]. 61
31987675 2020
46
Rate of strokes 1 year after retinal artery occlusion with analysis of risk groups. 61
30782009 2020
47
Acute phase treatment in central retinal artery occlusion: thrombolysis, hyperbaric oxygen therapy or both? 61
32166539 2020
48
The Use of Vitamins and Coenzyme Q10 for the Treatment of Vascular Occlusion Diseases Affecting the Retina. 61
32182869 2020
49
Branch Retinal Artery Occlusion as a presenting sign of Acute Retinal Necrosis: a rare association. 61
32052206 2020
50
Branch retinal artery occlusion in a patient undergoing Methotrexate therapy for ectopic pregnancy: A case report. 61
32063635 2020

Variations for Branch Retinal Artery Occlusion

Expression for Branch Retinal Artery Occlusion

Search GEO for disease gene expression data for Branch Retinal Artery Occlusion.

Pathways for Branch Retinal Artery Occlusion

GO Terms for Branch Retinal Artery Occlusion

Cellular components related to Branch Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.8 SERPINC1 PLG F2

Biological processes related to Branch Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibrinolysis GO:0042730 9.37 PLG F2
2 regulation of blood coagulation GO:0030193 9.32 SERPINC1 F2
3 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.26 VEGFA PLG
4 negative regulation of fibrinolysis GO:0051918 9.16 PLG F2
5 hemostasis GO:0007599 9.13 SERPINC1 PLG F2
6 blood coagulation GO:0007596 8.92 SERPINC1 PLG F2 BLOC1S6

Molecular functions related to Branch Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 VEGFA SERPINC1 F2

Sources for Branch Retinal Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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