MCID: BRC085
MIFTS: 11

Brca2 Hereditary Breast and Ovarian Cancer Syndrome

Categories: Rare diseases, Cancer diseases, Genetic diseases

Aliases & Classifications for Brca2 Hereditary Breast and Ovarian Cancer Syndrome

MalaCards integrated aliases for Brca2 Hereditary Breast and Ovarian Cancer Syndrome:

Name: Brca2 Hereditary Breast and Ovarian Cancer Syndrome 53
Cancer, Breast-Ovarian, Familial, Susceptibility to, Type 2 40
Familial Susceptibility to Breast-Ovarian Cancer 2 53
Brovca2 53
Hboc 53

Classifications:



Summaries for Brca2 Hereditary Breast and Ovarian Cancer Syndrome

NIH Rare Diseases : 53 BRCA2 hereditary breast and ovarian cancersyndrome (BRCA2 HBOC) is an inherited condition that is characterized by an increased risk for a variety of different cancers. Women with this condition have a 49-55% risk of developing breast cancer, a 16-18% risk of developing ovarian cancer and a 62% risk of developing contralateral breast cancer by age 70. Men have a 6% lifetime risk of breast cancer and an increased risk for prostate cancer. Both men and women with BRCA2 HBOC have an elevated risk for pancreatic cancer. BRCA2 HBOC may also be associated with cancers of the stomach, gallbladder, bile duct, esophagus, stomach, fallopian tube, primary peritoneum, and skin; however, these risks are not well defined. This condition is caused by changes (mutations) in the BRCA2 gene and is inherited in an autosomal dominant manner. Management may include high risk cancer screening, chemopreventation and/or prophylactic surgeries.

MalaCards based summary : Brca2 Hereditary Breast and Ovarian Cancer Syndrome, also known as cancer, breast-ovarian, familial, susceptibility to, type 2, is related to hereditary breast ovarian cancer syndrome and pancreatic cancer. Affiliated tissues include breast, prostate and skin.

Related Diseases for Brca2 Hereditary Breast and Ovarian Cancer Syndrome

Diseases related to Brca2 Hereditary Breast and Ovarian Cancer Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hereditary breast ovarian cancer syndrome 11.5
2 pancreatic cancer 11.3
3 ovarian cancer 11.3
4 breast-ovarian cancer, familial 2 11.1
5 brca1 hereditary breast and ovarian cancer syndrome 11.1

Graphical network of the top 20 diseases related to Brca2 Hereditary Breast and Ovarian Cancer Syndrome:



Diseases related to Brca2 Hereditary Breast and Ovarian Cancer Syndrome

Symptoms & Phenotypes for Brca2 Hereditary Breast and Ovarian Cancer Syndrome

Drugs & Therapeutics for Brca2 Hereditary Breast and Ovarian Cancer Syndrome

Search Clinical Trials , NIH Clinical Center for Brca2 Hereditary Breast and Ovarian Cancer Syndrome

Genetic Tests for Brca2 Hereditary Breast and Ovarian Cancer Syndrome

Anatomical Context for Brca2 Hereditary Breast and Ovarian Cancer Syndrome

MalaCards organs/tissues related to Brca2 Hereditary Breast and Ovarian Cancer Syndrome:

41
Breast, Prostate, Skin

Publications for Brca2 Hereditary Breast and Ovarian Cancer Syndrome

Variations for Brca2 Hereditary Breast and Ovarian Cancer Syndrome

Expression for Brca2 Hereditary Breast and Ovarian Cancer Syndrome

Search GEO for disease gene expression data for Brca2 Hereditary Breast and Ovarian Cancer Syndrome.

Pathways for Brca2 Hereditary Breast and Ovarian Cancer Syndrome

GO Terms for Brca2 Hereditary Breast and Ovarian Cancer Syndrome

Sources for Brca2 Hereditary Breast and Ovarian Cancer Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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