MCID: BRS023
MIFTS: 37

Breast Adenoid Cystic Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Breast Adenoid Cystic Carcinoma

MalaCards integrated aliases for Breast Adenoid Cystic Carcinoma:

Name: Breast Adenoid Cystic Carcinoma 12 15
Adenoid Cystic Breast Carcinoma 17 74
Adenoid Cystic Carcinoma of Breast 12
Mammary Adenocystic Carcinoma 12

Classifications:



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Disease Ontology 12 DOID:4877
NCIt 51 C5130
UMLS 74 C1332167

Summaries for Breast Adenoid Cystic Carcinoma

Disease Ontology : 12 A breast carcinoma that is characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns.

MalaCards based summary : Breast Adenoid Cystic Carcinoma, also known as adenoid cystic breast carcinoma, is related to adenoid cystic carcinoma and breast cancer, and has symptoms including pain An important gene associated with Breast Adenoid Cystic Carcinoma is NFIB (Nuclear Factor I B), and among its related pathways/superpathways are Gene Expression and Pathways in cancer. Affiliated tissues include breast, ovary and lung, and related phenotypes are Decreased viability in esophageal squamous lineage and endocrine/exocrine gland

Related Diseases for Breast Adenoid Cystic Carcinoma

Diseases related to Breast Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 adenoid cystic carcinoma 30.3 ERBB2 KIT MYBL1 NFIB PGR
2 breast cancer 28.4 AR ERBB2 ESR1 KIT PGR TOP2A
3 scirrhous adenocarcinoma 10.2 ERBB2 PGR
4 breast apocrine carcinoma 10.2 ERBB2 PGR
5 cutaneous adenocystic carcinoma 10.2 MYBL1 NFIB
6 intracystic papillary adenoma 10.2 ERBB2 PGR
7 breast metaplastic carcinoma 10.2 ERBB2 PGR
8 progesterone-receptor negative breast cancer 10.2 ERBB2 PGR
9 lung adenoid cystic carcinoma 10.2 KIT NFIB
10 uterine body mixed cancer 10.2 ERBB2 PGR
11 microglandular adenosis 10.2 ERBB2 PGR
12 leiomyomatosis 10.2 ESR1 PGR
13 benign breast phyllodes tumor 10.2 KIT PGR
14 cystic nephroma 10.2 KIT PGR
15 vestibular gland benign neoplasm 10.1 ESR1 PGR
16 bartholin's gland adenoma 10.1 ESR1 PGR
17 vulvar syringoma 10.1 ESR1 PGR
18 lung leiomyoma 10.1 ESR1 PGR
19 breast secretory carcinoma 10.1 ERBB2 PGR
20 polymorphous low-grade adenocarcinoma 10.1 KIT NFIB
21 perivascular epithelioid cell tumor 10.1 KIT PGR
22 vulvar benign neoplasm 10.1 ESR1 PGR
23 trigonitis 10.1 ESR1 PGR
24 vulvar leiomyoma 10.1 ESR1 PGR
25 predominantly cortical thymoma 10.1 ESR1 PGR
26 bartholin's gland benign neoplasm 10.1 ESR1 PGR
27 progesterone resistance 10.1 ESR1 PGR
28 endometrial mucinous adenocarcinoma 10.1 ESR1 PGR
29 dermoid cyst 10.1 KIT PGR
30 deep angioma 10.1 ESR1 PGR
31 synchronous bilateral breast carcinoma 10.1 ESR1 PGR
32 bilateral breast cancer 10.1 ERBB2 PGR
33 female reproductive endometrioid cancer 10.1 ESR1 PGR
34 comedo carcinoma 10.1 ERBB2 ESR1
35 primary peritoneal carcinoma 10.1 ERBB2 PGR
36 cervical carcinosarcoma 10.1 ESR1 PGR
37 estrogen excess 10.1 ESR1 PGR
38 intramuscular hemangioma 10.1 ESR1 PGR
39 glycogen-rich clear cell breast carcinoma 10.1 ESR1 PGR
40 mammographic density 10.1 ESR1 PGR
41 cervical clear cell adenocarcinoma 10.1 ESR1 PGR
42 ewing's family of tumors 10.1 ERBB2 KIT
43 retinitis pigmentosa 47 10.1 ESR1 PGR
44 papillary adenocarcinoma 10.1 ERBB2 PGR
45 retinitis pigmentosa 20 10.1 ESR1 PGR
46 endometriosis of ovary 10.1 ESR1 PGR
47 uterine benign neoplasm 10.0 ESR1 PGR
48 lobular neoplasia 10.0 ERBB2 ESR1
49 dysgerminoma of ovary 10.0 KIT PGR
50 endometritis 10.0 ESR1 PGR

Graphical network of the top 20 diseases related to Breast Adenoid Cystic Carcinoma:



Diseases related to Breast Adenoid Cystic Carcinoma

Symptoms & Phenotypes for Breast Adenoid Cystic Carcinoma

UMLS symptoms related to Breast Adenoid Cystic Carcinoma:


pain

GenomeRNAi Phenotypes related to Breast Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.17 ACTN1 ERBB2 ESR1 KIT MYBL1 NFIB

MGI Mouse Phenotypes related to Breast Adenoid Cystic Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.95 AR ERBB2 ESR1 KIT MYBL1 NFIB
2 integument MP:0010771 9.85 AR ERBB2 ESR1 KIT MYBL1 PGR
3 digestive/alimentary MP:0005381 9.83 AR ERBB2 ESR1 KIT NFIB
4 limbs/digits/tail MP:0005371 9.72 AR ERBB2 ESR1 KIT PGR
5 muscle MP:0005369 9.65 AR ERBB2 ESR1 KIT PGR
6 neoplasm MP:0002006 9.55 AR ERBB2 ESR1 KIT PGR
7 normal MP:0002873 9.43 AR ERBB2 ESR1 KIT MYBL1 PGR
8 reproductive system MP:0005389 9.1 AR ERBB2 ESR1 KIT MYBL1 PGR

Drugs & Therapeutics for Breast Adenoid Cystic Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Adenoid Cystic Carcinoma

Genetic Tests for Breast Adenoid Cystic Carcinoma

Anatomical Context for Breast Adenoid Cystic Carcinoma

MalaCards organs/tissues related to Breast Adenoid Cystic Carcinoma:

42
Breast, Ovary, Lung, Salivary Gland, Bone, Prostate, Smooth Muscle

Publications for Breast Adenoid Cystic Carcinoma

Articles related to Breast Adenoid Cystic Carcinoma:

(show all 14)
# Title Authors Year
1
Discordant correlation of breast adenoid cystic carcinoma on imaging and pathology: A case report and literature review on surgical management. ( 29268125 )
2018
2
Breast adenoid cystic carcinoma: report of a case with emphasis on routine sonographic findings and shear wave elastography. ( 28382475 )
2018
3
MYB Labeling by Immunohistochemistry Is More Sensitive and Specific for Breast Adenoid Cystic Carcinoma than MYB Labeling by FISH. ( 28498281 )
2017
4
Breast Adenoid Cystic Carcinoma: A Rare Case Report and Review of the Literature. ( 28798006 )
2017
5
18F-FDG PET/CT Imaging of Bilateral Renal Metastasis of Breast Adenoid Cystic Carcinoma. ( 26562575 )
2016
6
Cutaneous metastasis of breast adenoid cystic carcinoma to the scalp. ( 26968987 )
2016
7
Breast adenoid cystic carcinoma in a 19-year-old man: a case report and review of the literature. ( 25885366 )
2015
8
Male breast adenoid cystic carcinoma. ( 24403896 )
2013
9
Clinical review--breast adenoid cystic carcinoma. ( 22154460 )
2012
10
Adolescent male adenoid cystic breast carcinoma. ( 22546110 )
2012
11
Adolescent male adenoid cystic breast carcinoma. ( 22691333 )
2012
12
Adenoid cystic breast carcinoma: is axillary staging necessary in all cases? Results from the California Cancer Registry. ( 21790841 )
2011
13
Adenoid cystic breast carcinoma: high rates of margin positivity after breast conserving surgery. ( 19730354 )
2010
14
Adenoid cystic breast carcinoma: a salivary gland-type tumour with excellent prognosis and implications for management. ( 18446636 )
2008

Variations for Breast Adenoid Cystic Carcinoma

Cosmic variations for Breast Adenoid Cystic Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM25159 PTEN breast,NS,carcinoma,adenoid cystic carcinoma c.254-3C>T p.? 10:87933010-87933010 0
2 COSM6962729 PIM1 breast,NS,carcinoma,adenoid cystic carcinoma c.524T>C p.I175T 6:37171408-37171408 0
3 COSM27376 PIK3CA breast,NS,carcinoma,adenoid cystic carcinoma c.93A>G p.I31M 3:179198918-179198918 0
4 COSM6962730 CREBBP breast,NS,carcinoma,adenoid cystic carcinoma c.3517C>G p.R1173G 16:3757901-3757901 0
5 COSM467 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1781A>G p.D594G 7:140753354-140753354 0
6 COSM449 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1391G>A p.G464E 7:140781617-140781617 0
7 COSM476 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1799T>A p.V600E 7:140753336-140753336 0

Expression for Breast Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Breast Adenoid Cystic Carcinoma.

Pathways for Breast Adenoid Cystic Carcinoma

GO Terms for Breast Adenoid Cystic Carcinoma

Biological processes related to Breast Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.93 AR ESR1 MYBL1 NFIB PGR
2 transcription initiation from RNA polymerase II promoter GO:0006367 9.67 AR ESR1 PGR
3 positive regulation of protein kinase B signaling GO:0051897 9.65 ERBB2 ESR1 KIT
4 positive regulation of MAPK cascade GO:0043410 9.61 AR ERBB2 KIT
5 intracellular receptor signaling pathway GO:0030522 9.52 AR ESR1
6 stem cell differentiation GO:0048863 9.51 ESR1 KIT
7 male gonad development GO:0008584 9.5 AR ESR1 KIT
8 mammary gland alveolus development GO:0060749 9.46 AR ESR1
9 steroid hormone mediated signaling pathway GO:0043401 9.43 AR ESR1 PGR
10 positive regulation of transcription by RNA polymerase II GO:0045944 9.43 AR ESR1 MYBL1 NFIB PGR TOP2A
11 positive regulation of phospholipase C activity GO:0010863 9.4 ESR1 KIT
12 transcription, DNA-templated GO:0006351 9.16 AR ESR1
13 positive regulation of transcription by RNA polymerase III GO:0045945 9.07 AR
14 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 8.62 AR PGR

Molecular functions related to Breast Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.88 AR ESR1 MYBL1 NFIB PGR TOP2A
2 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.83 AR ESR1 MYBL1 NFIB PGR
3 enzyme binding GO:0019899 9.67 AR ESR1 PGR TOP2A
4 lipid binding GO:0008289 9.63 AR ESR1 PGR
5 ATPase binding GO:0051117 9.5 AR ESR1 PGR
6 steroid hormone receptor activity GO:0003707 9.43 AR ESR1 PGR
7 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.35 AR ESR1 MYBL1 NFIB PGR
8 nuclear receptor activity GO:0004879 9.33 AR ESR1 PGR
9 steroid binding GO:0005496 8.8 AR ESR1 PGR

Sources for Breast Adenoid Cystic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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