MCID: BRS023
MIFTS: 37

Breast Adenoid Cystic Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Breast Adenoid Cystic Carcinoma

MalaCards integrated aliases for Breast Adenoid Cystic Carcinoma:

Name: Breast Adenoid Cystic Carcinoma 12 15
Adenoid Cystic Carcinoma of Breast 12
Adenoid Cystic Breast Carcinoma 73
Mammary Adenocystic Carcinoma 12

Classifications:



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Disease Ontology 12 DOID:4877
NCIt 50 C5130
UMLS 73 C1332167

Summaries for Breast Adenoid Cystic Carcinoma

Disease Ontology : 12 A breast carcinoma that is characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns.

MalaCards based summary : Breast Adenoid Cystic Carcinoma, also known as adenoid cystic carcinoma of breast, is related to adenoid cystic carcinoma and scirrhous adenocarcinoma, and has symptoms including pain An important gene associated with Breast Adenoid Cystic Carcinoma is NFIB (Nuclear Factor I B), and among its related pathways/superpathways are Gene Expression and Pathways in cancer. Affiliated tissues include lung, bone and ovary, and related phenotypes are Decreased viability in esophageal squamous lineage and endocrine/exocrine gland

Related Diseases for Breast Adenoid Cystic Carcinoma

Diseases related to Breast Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 adenoid cystic carcinoma 30.4 ERBB2 KIT MYBL1 NFIB PGR
2 scirrhous adenocarcinoma 10.2 ERBB2 PGR
3 breast apocrine carcinoma 10.2 ERBB2 PGR
4 cutaneous adenocystic carcinoma 10.1 MYBL1 NFIB
5 intracystic papillary adenoma 10.1 ERBB2 PGR
6 breast metaplastic carcinoma 10.1 ERBB2 PGR
7 progesterone-receptor negative breast cancer 10.1 ERBB2 PGR
8 lung adenoid cystic carcinoma 10.1 KIT NFIB
9 uterine body mixed cancer 10.1 ERBB2 PGR
10 microglandular adenosis 10.1 ERBB2 PGR
11 leiomyomatosis 10.1 ESR1 PGR
12 benign breast phyllodes tumor 10.1 KIT PGR
13 cystic nephroma 10.1 KIT PGR
14 vestibular gland benign neoplasm 10.1 ESR1 PGR
15 bartholin's gland adenoma 10.1 ESR1 PGR
16 vulvar syringoma 10.1 ESR1 PGR
17 breast secretory carcinoma 10.1 ERBB2 PGR
18 lung leiomyoma 10.1 ESR1 PGR
19 polymorphous low-grade adenocarcinoma 10.1 KIT NFIB
20 perivascular epithelioid cell tumor 10.1 KIT PGR
21 vulvar benign neoplasm 10.1 ESR1 PGR
22 trigonitis 10.1 ESR1 PGR
23 vulvar leiomyoma 10.1 ESR1 PGR
24 predominantly cortical thymoma 10.1 ESR1 PGR
25 bartholin's gland benign neoplasm 10.1 ESR1 PGR
26 progesterone resistance 10.1 ESR1 PGR
27 endometrial mucinous adenocarcinoma 10.1 ESR1 PGR
28 dermoid cyst 10.1 KIT PGR
29 deep angioma 10.1 ESR1 PGR
30 synchronous bilateral breast carcinoma 10.1 ESR1 PGR
31 bilateral breast cancer 10.1 ERBB2 PGR
32 female reproductive endometrioid cancer 10.1 ESR1 PGR
33 comedo carcinoma 10.1 ERBB2 ESR1
34 primary peritoneal carcinoma 10.1 ERBB2 PGR
35 cervical carcinosarcoma 10.1 ESR1 PGR
36 estrogen excess 10.1 ESR1 PGR
37 intramuscular hemangioma 10.1 ESR1 PGR
38 glycogen-rich clear cell breast carcinoma 10.1 ESR1 PGR
39 mammographic density 10.1 ESR1 PGR
40 cervical clear cell adenocarcinoma 10.0 ESR1 PGR
41 ewing's family of tumors 10.0 ERBB2 KIT
42 retinitis pigmentosa 47 10.0 ESR1 PGR
43 papillary adenocarcinoma 10.0 ERBB2 PGR
44 retinitis pigmentosa 20 10.0 ESR1 PGR
45 endometriosis of ovary 10.0 ESR1 PGR
46 uterine benign neoplasm 10.0 ESR1 PGR
47 lobular neoplasia 10.0 ERBB2 ESR1
48 dysgerminoma of ovary 10.0 KIT PGR
49 endometritis 10.0 ESR1 PGR
50 hidradenocarcinoma 10.0 ERBB2 ESR1

Graphical network of the top 20 diseases related to Breast Adenoid Cystic Carcinoma:



Diseases related to Breast Adenoid Cystic Carcinoma

Symptoms & Phenotypes for Breast Adenoid Cystic Carcinoma

UMLS symptoms related to Breast Adenoid Cystic Carcinoma:


pain

GenomeRNAi Phenotypes related to Breast Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.17 ACTN1 ERBB2 ESR1 KIT MYBL1 NFIB

MGI Mouse Phenotypes related to Breast Adenoid Cystic Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.95 AR ERBB2 ESR1 KIT MYBL1 NFIB
2 integument MP:0010771 9.85 AR ERBB2 ESR1 KIT MYBL1 PGR
3 digestive/alimentary MP:0005381 9.83 AR ERBB2 ESR1 KIT NFIB
4 limbs/digits/tail MP:0005371 9.72 AR ERBB2 ESR1 KIT PGR
5 muscle MP:0005369 9.65 AR ERBB2 ESR1 KIT PGR
6 neoplasm MP:0002006 9.55 AR ERBB2 ESR1 KIT PGR
7 normal MP:0002873 9.43 AR ERBB2 ESR1 KIT MYBL1 PGR
8 reproductive system MP:0005389 9.1 AR ERBB2 ESR1 KIT MYBL1 PGR

Drugs & Therapeutics for Breast Adenoid Cystic Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Adenoid Cystic Carcinoma

Genetic Tests for Breast Adenoid Cystic Carcinoma

Anatomical Context for Breast Adenoid Cystic Carcinoma

MalaCards organs/tissues related to Breast Adenoid Cystic Carcinoma:

41
Lung, Bone, Ovary, Prostate, Cervix, Smooth Muscle

Publications for Breast Adenoid Cystic Carcinoma

Articles related to Breast Adenoid Cystic Carcinoma:

# Title Authors Year
1
Discordant correlation of breast adenoid cystic carcinoma on imaging and pathology: A case report and literature review on surgical management. ( 29268125 )
2018
2
MYB Labeling by Immunohistochemistry Is More Sensitive and Specific for Breast Adenoid Cystic Carcinoma than MYB Labeling by FISH. ( 28498281 )
2017
3
Breast adenoid cystic carcinoma: report of a case with emphasis on routine sonographic findings and shear wave elastography. ( 28382475 )
2017
4
Breast Adenoid Cystic Carcinoma: A Rare Case Report and Review of the Literature. ( 28798006 )
2017
5
Cutaneous Metastasis of Breast Adenoid Cystic Carcinoma to the Scalp. ( 26968987 )
2016
6
Breast adenoid cystic carcinoma in a 19-year-old man: a case report and review of the literature. ( 25885366 )
2015
7
18F-FDG PET/CT Imaging of Bilateral Renal Metastasis of Breast Adenoid Cystic Carcinoma. ( 26562575 )
2015
8
Male breast adenoid cystic carcinoma. ( 24403896 )
2013
9
Clinical review--breast adenoid cystic carcinoma. ( 22154460 )
2012

Variations for Breast Adenoid Cystic Carcinoma

Cosmic variations for Breast Adenoid Cystic Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM25159 PTEN breast,NS,carcinoma,adenoid cystic carcinoma c.254-3C>T p.? 10:87933010-87933010 14
2 COSM6962729 PIM1 breast,NS,carcinoma,adenoid cystic carcinoma c.524T>C p.I175T 6:37171408-37171408 14
3 COSM27376 PIK3CA breast,NS,carcinoma,adenoid cystic carcinoma c.93A>G p.I31M 3:179198918-179198918 14
4 COSM6962730 CREBBP breast,NS,carcinoma,adenoid cystic carcinoma c.3517C>G p.R1173G 16:3757901-3757901 14
5 COSM476 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1799T>A p.V600E 7:140753336-140753336 14
6 COSM467 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1781A>G p.D594G 7:140753354-140753354 14
7 COSM449 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1391G>A p.G464E 7:140781617-140781617 14

Expression for Breast Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Breast Adenoid Cystic Carcinoma.

Pathways for Breast Adenoid Cystic Carcinoma

GO Terms for Breast Adenoid Cystic Carcinoma

Biological processes related to Breast Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.95 AR ESR1 MYBL1 NFIB PGR
2 transcription initiation from RNA polymerase II promoter GO:0006367 9.69 AR ESR1 PGR
3 positive regulation of protein kinase B signaling GO:0051897 9.67 ERBB2 ESR1 KIT
4 positive regulation of MAPK cascade GO:0043410 9.63 AR ERBB2 KIT
5 phosphatidylinositol phosphorylation GO:0046854 9.58 ERBB2 ESR1 KIT
6 intracellular receptor signaling pathway GO:0030522 9.54 AR ESR1
7 stem cell differentiation GO:0048863 9.52 ESR1 KIT
8 male gonad development GO:0008584 9.5 AR ESR1 KIT
9 mammary gland alveolus development GO:0060749 9.48 AR ESR1
10 transcription, DNA-templated GO:0006351 9.46 AR ESR1 NFIB PGR
11 positive regulation of phospholipase C activity GO:0010863 9.43 ESR1 KIT
12 steroid hormone mediated signaling pathway GO:0043401 9.43 AR ESR1 PGR
13 positive regulation of transcription by RNA polymerase II GO:0045944 9.43 AR ESR1 MYBL1 NFIB PGR TOP2A
14 positive regulation of transcription by RNA polymerase III GO:0045945 9.37 AR ERBB2
15 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 8.62 AR PGR

Molecular functions related to Breast Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.93 AR ESR1 MYBL1 NFIB PGR TOP2A
2 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.88 AR ESR1 MYBL1 NFIB PGR
3 enzyme binding GO:0019899 9.73 AR ESR1 PGR TOP2A
4 lipid binding GO:0008289 9.67 AR ESR1 PGR
5 ATPase binding GO:0051117 9.58 AR ESR1 PGR
6 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.55 AR ESR1 MYBL1 NFIB PGR
7 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.54 ERBB2 ESR1 KIT
8 steroid hormone receptor activity GO:0003707 9.5 AR ESR1 PGR
9 nuclear receptor activity GO:0004879 9.43 AR ESR1 PGR
10 steroid binding GO:0005496 9.13 AR ESR1 PGR
11 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 9.02 AR ESR1 MYBL1 NFIB PGR

Sources for Breast Adenoid Cystic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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