MCID: BRS023
MIFTS: 33

Breast Adenoid Cystic Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Breast Adenoid Cystic Carcinoma

MalaCards integrated aliases for Breast Adenoid Cystic Carcinoma:

Name: Breast Adenoid Cystic Carcinoma 12 15
Adenoid Cystic Breast Carcinoma 17 70
Adenoid Cystic Carcinoma of Breast 12
Mammary Adenocystic Carcinoma 12

Classifications:



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Disease Ontology 12 DOID:4877
NCIt 50 C5130
UMLS 70 C1332167

Summaries for Breast Adenoid Cystic Carcinoma

Disease Ontology : 12 A breast carcinoma that is characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns.

MalaCards based summary : Breast Adenoid Cystic Carcinoma, also known as adenoid cystic breast carcinoma, is related to adenoid cystic carcinoma and microglandular adenosis, and has symptoms including pain An important gene associated with Breast Adenoid Cystic Carcinoma is NFIB (Nuclear Factor I B), and among its related pathways/superpathways are Signaling by ERBB4 and Pathways Affected in Adenoid Cystic Carcinoma. Affiliated tissues include breast, salivary gland and kidney, and related phenotypes are no phenotypic analysis and normal

Related Diseases for Breast Adenoid Cystic Carcinoma

Diseases related to Breast Adenoid Cystic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 adenoid cystic carcinoma 30.4 PGR NTRK3 NFIB MYBL1 ERBB2
2 microglandular adenosis 30.1 PGR ESR1 ERBB2
3 in situ carcinoma 30.1 PGR ESR1 ERBB2
4 ductal carcinoma in situ 30.0 PGR ESR1 ERBB2
5 breast ductal carcinoma 30.0 PGR ESR1 ERBB2
6 lung adenoid cystic carcinoma 10.3 NFIB MYBL1
7 lacrimal gland adenocarcinoma 10.3 NFIB MYBL1
8 lacrimal system cancer 10.3 NFIB MYBL1
9 eccrine papillary adenocarcinoma 10.2 PGR MYBL1
10 scirrhous adenocarcinoma 10.2 PGR ERBB2
11 lipid-rich breast carcinoma 10.2 PGR ERBB2
12 apocrine adenosis of breast 10.2 PGR ERBB2
13 luminal breast carcinoma b 10.2 PGR ERBB2
14 breast mucinous carcinoma 10.2 PGR ERBB2
15 gastric diffuse adenocarcinoma 10.2 PGR ERBB2
16 linitis plastica 10.2 PGR ERBB2
17 lacrimal gland carcinoma 10.2 NFIB MYBL1
18 breast sarcoma 10.2 PGR ERBB2
19 triple-receptor negative breast cancer 10.2 PGR ERBB2
20 breast papillomatosis 10.2 PGR ERBB2
21 bartholin's gland adenoma 10.2 PGR ESR1
22 primary peritoneal carcinoma 10.2 PGR ERBB2
23 bartholin's gland adenoid cystic carcinoma 10.2 PGR ESR1
24 uterine corpus adenosarcoma 10.2 PGR ESR1
25 bartholin's gland benign neoplasm 10.2 PGR ESR1
26 chronic tympanitis 10.2 PGR ESR1
27 vestibular gland benign neoplasm 10.2 PGR ESR1
28 granulomatous endometritis 10.2 PGR ESR1
29 endometritis 10.2 PGR ESR1
30 vulvar syringoma 10.2 PGR ESR1
31 lung leiomyoma 10.2 PGR ESR1
32 cutaneous adenocystic carcinoma 10.2 PGR NFIB MYBL1
33 adult type testicular granulosa cell tumor 10.2 PGR ESR1
34 pregnancy adenoma 10.2 PGR NTRK3
35 cervical clear cell adenocarcinoma 10.2 PGR ESR1
36 ovarian seromucinous carcinoma 10.2 PGR ESR1
37 liver leiomyoma 10.1 PGR ESR1
38 intravenous leiomyomatosis 10.1 PGR ESR1
39 intracranial meningioma 10.1 PGR ESR1
40 polymorphous low-grade adenocarcinoma 10.1 NTRK3 NFIB
41 vulvar leiomyoma 10.1 PGR ESR1
42 bizarre leiomyoma 10.1 PGR ESR1
43 breast adenoma 10.1 PGR ESR1
44 prostate stromal sarcoma 10.1 PGR ESR1
45 rare tumor 10.1
46 urethral benign neoplasm 10.1 PGR ESR1
47 cervical adenosarcoma 10.1 PGR ESR1
48 gender identity disorder 10.1 PGR ESR1
49 progesterone resistance 10.1 PGR ESR1
50 biphasic synovial sarcoma 10.1 PGR ESR1

Graphical network of the top 20 diseases related to Breast Adenoid Cystic Carcinoma:



Diseases related to Breast Adenoid Cystic Carcinoma

Symptoms & Phenotypes for Breast Adenoid Cystic Carcinoma

UMLS symptoms related to Breast Adenoid Cystic Carcinoma:


pain

MGI Mouse Phenotypes related to Breast Adenoid Cystic Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.35 ACTN1 ESR1 ETV6 NTRK3 PGR
2 normal MP:0002873 9.1 ERBB2 ESR1 ETV6 MYBL1 NTRK3 PGR

Drugs & Therapeutics for Breast Adenoid Cystic Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Adenoid Cystic Carcinoma

Genetic Tests for Breast Adenoid Cystic Carcinoma

Anatomical Context for Breast Adenoid Cystic Carcinoma

MalaCards organs/tissues related to Breast Adenoid Cystic Carcinoma:

40
Breast, Salivary Gland, Kidney, Lung, Ovary, Cervix, Cortex

Publications for Breast Adenoid Cystic Carcinoma

Articles related to Breast Adenoid Cystic Carcinoma:

(show all 22)
# Title Authors PMID Year
1
Management of Adenoid Cystic Carcinoma of the Breast: A Single-Institution Study. 61
33791208 2021
2
Treatment Patterns and Clinical Outcomes of Adenoid Cystic Breast Carcinoma: A Single-Institution Experience. 61
32845724 2020
3
Breast Adenoid Cystic Carcinoma in a patient with Previous Contra-lateral Breast Ductal Carcinoma in-situ: A Case Report. 61
32876025 2020
4
Adenoid cystic carcinomas of the salivary gland, lacrimal gland, and breast are morphologically and genetically similar but have distinct microRNA expression profiles. 61
29467480 2018
5
MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB-NFIB fusion gene. 61
29149504 2018
6
Discordant correlation of breast adenoid cystic carcinoma on imaging and pathology: A case report and literature review on surgical management. 61
29268125 2018
7
Breast adenoid cystic carcinoma: report of a case with emphasis on routine sonographic findings and shear wave elastography. 61
28382475 2018
8
MYB Labeling by Immunohistochemistry Is More Sensitive and Specific for Breast Adenoid Cystic Carcinoma than MYB Labeling by FISH. 61
28498281 2017
9
Breast Adenoid Cystic Carcinoma: A Rare Case Report and Review of the Literature. 61
28798006 2017
10
Cutaneous metastasis of breast adenoid cystic carcinoma to the scalp. 61
26968987 2016
11
18F-FDG PET/CT Imaging of Bilateral Renal Metastasis of Breast Adenoid Cystic Carcinoma. 61
26562575 2016
12
Breast adenoid cystic carcinoma in a 19-year-old man: a case report and review of the literature. 61
25885366 2015
13
Male breast adenoid cystic carcinoma. 61
24403896 2013
14
Adolescent male adenoid cystic breast carcinoma. 61
22546110 2012
15
Adolescent male adenoid cystic breast carcinoma. 61
22691333 2012
16
Clinical review--breast adenoid cystic carcinoma. 61
22154460 2012
17
Adenoid cystic breast carcinoma: is axillary staging necessary in all cases? Results from the California Cancer Registry. 61
21790841 2011
18
Adenoid cystic carcinomas of the breast have low Topo II╬▒ expression but frequently overexpress EGFR protein without EGFR gene amplification. 61
20688355 2010
19
Adenoid cystic breast carcinoma: high rates of margin positivity after breast conserving surgery. 61
19730354 2010
20
Adenoid cystic breast carcinoma: a salivary gland-type tumour with excellent prognosis and implications for management. 61
18446636 2008
21
Expression of c-kit in adenoid cystic carcinoma of the breast. 61
16203286 2005
22
Fine-needle aspiration biopsy of adenoid cystic carcinoma of the breast: a case report. 61
8989549 1996

Variations for Breast Adenoid Cystic Carcinoma

Cosmic variations for Breast Adenoid Cystic Carcinoma:

9 (show all 18)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM96848689 PTEN breast,NS,carcinoma,adenoid cystic carcinoma c.254-3C>T p.? 10:87933010-87933010 12
2 COSM98225556 PIM1 breast,NS,carcinoma,adenoid cystic carcinoma c.524T>C p.I175T 6:37171408-37171408 12
3 COSM148949265 PIK3CA breast,NS,carcinoma,adenoid cystic carcinoma c.93A>G p.I31M 3:179198918-179198918 12
4 COSM87150468 PIK3CA breast,NS,carcinoma,adenoid cystic carcinoma c.93A>G p.I31M 3:179198918-179198918 12
5 COSM84225444 CREBBP breast,NS,carcinoma,adenoid cystic carcinoma c.3517C>G p.R1173G 16:3757901-3757901 12
6 COSM99657922 CREBBP breast,NS,carcinoma,adenoid cystic carcinoma c.3403C>G p.R1135G 16:3757901-3757901 12
7 COSM150571925 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1391G>A p.G464E 7:140781617-140781617 12
8 COSM118787231 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1799T>A p.V600E 7:140753336-140753336 12
9 COSM149395796 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1511G>A p.G504E 7:140781617-140781617 12
10 COSM149391362 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1901A>G p.D634G 7:140753354-140753354 12
11 COSM118796846 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1391G>A p.G464E 7:140781617-140781617 12
12 COSM88808836 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1901A>G p.D634G 7:140753354-140753354 12
13 COSM118792555 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1781A>G p.D594G 7:140753354-140753354 12
14 COSM149385292 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1919T>A p.V640E 7:140753336-140753336 12
15 COSM150567545 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1781A>G p.D594G 7:140753354-140753354 12
16 COSM88814352 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1511G>A p.G504E 7:140781617-140781617 12
17 COSM88803061 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1919T>A p.V640E 7:140753336-140753336 12
18 COSM150563774 BRAF breast,NS,carcinoma,adenoid cystic carcinoma c.1799T>A p.V600E 7:140753336-140753336 12

Expression for Breast Adenoid Cystic Carcinoma

Search GEO for disease gene expression data for Breast Adenoid Cystic Carcinoma.

Pathways for Breast Adenoid Cystic Carcinoma

Pathways related to Breast Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.17 PGR ESR1 ERBB2
2 10.62 NFIB MYBL1 ERBB2

GO Terms for Breast Adenoid Cystic Carcinoma

Biological processes related to Breast Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.65 PGR NFIB MYBL1 ETV6 ESR1
2 steroid hormone mediated signaling pathway GO:0043401 9.16 PGR ESR1
3 positive regulation of phospholipase C activity GO:0010863 8.96 NTRK3 ESR1
4 intracellular steroid hormone receptor signaling pathway GO:0030518 8.62 PGR ESR1

Molecular functions related to Breast Adenoid Cystic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.8 PGR NFIB MYBL1 ETV6 ESR1
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.77 PGR NFIB MYBL1 ETV6 ESR1
3 sequence-specific DNA binding GO:0043565 9.46 PGR MYBL1 ETV6 ESR1
4 DNA-binding transcription factor activity GO:0003700 9.35 PGR NFIB MYBL1 ETV6 ESR1
5 steroid binding GO:0005496 9.32 PGR ESR1
6 steroid hormone receptor activity GO:0003707 9.26 PGR ESR1
7 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.02 PGR NFIB MYBL1 ETV6 ESR1

Sources for Breast Adenoid Cystic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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