MCID: BRS045
MIFTS: 25

Breast Adenoma

Categories: Cancer diseases

Aliases & Classifications for Breast Adenoma

MalaCards integrated aliases for Breast Adenoma:

Name: Breast Adenoma 12 15 71
Ademoma - Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1625
NCIt 49 C40382
UMLS 71 C1328385

Summaries for Breast Adenoma

Disease Ontology : 12 A breast benign neoplasm that is has material basis in epithelial tissue in which tumor cells form glands or glandlike structures.

MalaCards based summary : Breast Adenoma, also known as ademoma - breast, is related to breast ductal adenoma and carney complex variant. An important gene associated with Breast Adenoma is PRKAR1A (Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha), and among its related pathways/superpathways are G alpha (s) signalling events and Signaling events mediated by PTP1B. Affiliated tissues include breast, pituitary and skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Breast Adenoma

Diseases related to Breast Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 47, show less)
# Related Disease Score Top Affiliating Genes
1 breast ductal adenoma 31.8 PRKAR1A PDE8B PDE11A
2 carney complex variant 31.5 PRL PRKAR1A PDE8B PDE11A
3 pregnancy adenoma 30.9 THBS3 TAAR6 NT5C1B KRT14
4 breast apocrine adenoma 11.2
5 adenoma 10.3
6 melanotic neurilemmoma 10.3 PRKAR1A PDE11A
7 galactorrhea 10.3 PRLR PRL
8 lipid-rich breast carcinoma 10.3 PRLR PRL
9 chromophobe adenoma 10.3 PRLR PRL
10 hormone producing pituitary cancer 10.2 PRL PRKAR1A
11 testicular sex cord-stromal neoplasm 10.2 PRKAR1A PDE11A
12 hyperpituitarism 10.2 PRL PRKAR1A
13 acth-secreting pituitary adenoma 10.2 PRL PRKAR1A
14 growth hormone secreting pituitary adenoma 10.1 PRL PRKAR1A
15 adrenal gland disease 10.1 PRL PRKAR1A PDE11A
16 functioning pituitary adenoma 10.1 PRLR PRL PRKAR1A
17 pseudohypoparathyroidism, type ia 10.1 PRL PRKAR1A
18 pituitary gland disease 10.1 PRLR PRL PRKAR1A
19 pseudohypoparathyroidism 10.0 PRL PRKAR1A
20 lipid-rich carcinoma 10.0 PRLR KRT14
21 acromegaly 10.0 PRLR PRL PRKAR1A
22 polyp of corpus uteri 10.0 PRL KRT14
23 rete ovarii adenoma 10.0 PRL KRT14
24 sex cord-gonadal stromal tumor 10.0 PRKAR1A PDE11A
25 rete ovarii neoplasm 10.0 PRL KRT14
26 basophil adenoma 10.0 PRKAR1A PDE8B PDE11A
27 salpingitis isthmica nodosa 10.0 PRL KRT14
28 acth-independent cushing syndrome 10.0 PRKAR1A PDE8B PDE11A
29 intracystic papillary adenoma 10.0 PRL KRT14
30 primary pigmented nodular adrenocortical disease 10.0 PRKAR1A PDE8B PDE11A
31 conn's syndrome 9.9 PRL PRKAR1A PDE11A
32 schizophrenia 5 9.9 TAAR6 PRL
33 breast cancer 9.7
34 squamous cell papilloma 9.7
35 breast fibroadenoma 9.7
36 papilloma 9.7
37 leydig cell tumor 9.7
38 sertoli-leydig cell tumor 9.7
39 skin papilloma 9.7
40 mammary paget's disease 9.7
41 subareolar duct papillomatosis 9.7
42 rare breast tumor 9.7
43 adrenal cortex disease 9.7 PRL PRKAR1A PDE8B PDE11A
44 mccune-albright syndrome 9.7 PRL PRKAR1A PDE8B PDE11A
45 thoracic benign neoplasm 9.7 PRLR PRL PRKAR1A KRT14
46 breast benign neoplasm 9.7 PRLR PRL PRKAR1A KRT14
47 osteoporosis 9.2 PRL PRKAR1A PDE8B PDE11A

Graphical network of the top 20 diseases related to Breast Adenoma:



Diseases related to Breast Adenoma

Symptoms & Phenotypes for Breast Adenoma

GenomeRNAi Phenotypes related to Breast Adenoma according to GeneCards Suite gene sharing:

26 (showing 12, show less)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.47 TAAR6
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.47 TAAR6
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.47 THBS3
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-171 9.47 AJAP1 TAAR6 THBS3
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.47 TAAR6
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.47 TAAR6
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.47 THBS3
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.47 THBS3
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.47 AJAP1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.47 THBS3
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.47 TAAR6
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-94 9.47 TAAR6

Drugs & Therapeutics for Breast Adenoma

Search Clinical Trials , NIH Clinical Center for Breast Adenoma

Genetic Tests for Breast Adenoma

Anatomical Context for Breast Adenoma

MalaCards organs/tissues related to Breast Adenoma:

40
Breast, Pituitary, Skin, Brain, Salivary Gland, Cortex, Adrenal Gland

Publications for Breast Adenoma

Articles related to Breast Adenoma:

(showing 24, show less)
# Title Authors PMID Year
1
[Possibilities of cytological diagnostics of lactated breast adenoma. Clinical report.] 61
31185151 2019
2
[Pathologic changes of spontaneous tumors in Sprague-Dawley and Wistar rats]. 61
28376591 2017
3
[EXPERIMENTAL MODEL AND CURRENCY OF EXPERIMENT OF DISTANT RESULTS OF LEAD EXPOSITION]. 61
28452739 2017
4
Association between the ornithine decarboxylase G316A polymorphism and breast cancer survival. 61
26171056 2015
5
Radio-sensitization by Piper longumine of human breast adenoma MDA-MB-231 cells in vitro. 61
24815473 2014
6
Ectopic breast adenoma of the anal margin: an atypical presentation of anorectal pain. 61
23229560 2013
7
Synchronous bilateral infiltrating syringomatous adenoma of the breast. 61
22555236 2012
8
Matched rabbit monoclonal antibodies against αv-series integrins reveal a novel αvβ3-LIBS epitope, and permit routine staining of archival paraffin samples of human tumors. 61
23213423 2012
9
Tubular adenoma of the breast: a rare presentation and review of the literature. 61
22383931 2012
10
Cyclosporine-A therapy-induced multiple bilateral breast and accessory axillary breast fibroadenomas: a case report. 61
20701786 2010
11
[Expression of PAK4 in breast cancer and benign breast pathological changes]. 61
20501374 2010
12
Personal history of endometriosis and risk of cutaneous melanoma in a large prospective cohort of French women. 61
17954799 2007
13
Mutation of p53 in skin papilloma and tubular breast adenoma of albino mice. 61
16624193 2006
14
Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity. 61
16024112 2005
15
[Rare pathology of the breast: adenoma of the nipple]. 61
12228975 2002
16
Expression of CD44 isoforms in normal salivary gland tissue: an immunohistochemical and ultrastructural study. 61
11201610 2000
17
Intranuclear Helioid Inclusions in a Case of Breast Carcinoma. 61
11348259 1999
18
Stereoscopically guided characterization of three-dimensional dynamic MR images of the breast. 61
8539396 1996
19
Benign breast lesions in Kenya: a histological study. 61
1644038 1992
20
Tubular adenoma of the breast in a pregnant girl: report on a case. 61
1777492 1991
21
Intranuclear helioid inclusions in mammary intraductal hyperplasias. 61
1651580 1991
22
Ollier's disease associated with ovarian Sertoli-Leydig cell tumor and breast adenoma. 61
2029079 1991
23
Adenoma of the nipple. 61
6617428 1983
24
An antigen associated with mesenchyme in human tumours that cross-reacts with brain glycoprotein. 61
89856 1979

Variations for Breast Adenoma

Expression for Breast Adenoma

Search GEO for disease gene expression data for Breast Adenoma.

Pathways for Breast Adenoma

Pathways related to Breast Adenoma according to GeneCards Suite gene sharing:

(showing 3, show less)
# Super pathways Score Top Affiliating Genes
1 10.96 TAAR6 PDE8B PDE11A
2 10.85 PRLR PRL
3
Show member pathways
10.57 PRLR PRL

GO Terms for Breast Adenoma

Cellular components related to Breast Adenoma according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.62 PRLR PRL

Biological processes related to Breast Adenoma according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 IRE1-mediated unfolded protein response GO:0036498 9.16 GET3 CXXC1
2 lactation GO:0007595 8.96 PRLR PRL
3 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.62 PRLR PRL

Molecular functions related to Breast Adenoma according to GeneCards Suite gene sharing:

(showing 2, show less)
# Name GO ID Score Top Affiliating Genes
1 phosphoric diester hydrolase activity GO:0008081 8.96 PDE8B PDE11A
2 3',5'-cyclic-GMP phosphodiesterase activity GO:0047555 8.62 PRKAR1A PDE11A

Sources for Breast Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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