MCID: BRS017
MIFTS: 33

Breast Adenomyoepithelioma

Categories: Cancer diseases

Aliases & Classifications for Breast Adenomyoepithelioma

MalaCards integrated aliases for Breast Adenomyoepithelioma:

Name: Breast Adenomyoepithelioma 12 15 74
Breast Adenomyoepithelioma with Malignant Change 12
Malignant Adenomyoepithelioma of Breast 12
Adenomyoepithelioma of the Breast 12

Classifications:



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Disease Ontology 12 DOID:1642
NCIt 51 C5143 C6899

Summaries for Breast Adenomyoepithelioma

Disease Ontology : 12 A breast myoepithelial neoplasm that affects the breast and is characterized by biphasic proliferation of both epithelial and myoepithelial cells.

MalaCards based summary : Breast Adenomyoepithelioma, also known as breast adenomyoepithelioma with malignant change, is related to benign breast adenomyoepithelioma and in situ carcinoma. An important gene associated with Breast Adenomyoepithelioma is HSD11B2 (Hydroxysteroid 11-Beta Dehydrogenase 2), and among its related pathways/superpathways are Ras signaling pathway and Cell surface interactions at the vascular wall. Affiliated tissues include breast, and related phenotypes are G0/1 arrest and cellular

Wikipedia : 77 An adenomyoepithelioma of the breast is a rare tumour in the breast composed of glandular elements... more...

Related Diseases for Breast Adenomyoepithelioma

Diseases in the Breast Adenomyoepithelioma family:

Benign Breast Adenomyoepithelioma

Diseases related to Breast Adenomyoepithelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 151)
# Related Disease Score Top Affiliating Genes
1 benign breast adenomyoepithelioma 33.8 KRT14 KRT5 KRT7
2 in situ carcinoma 30.6 CDH1 KRT14 KRT5
3 ductal carcinoma in situ 30.6 CDH1 KRT14 KRT5
4 adenoid cystic carcinoma 29.6 CDH1 KRT14 KRT5 KRT7 PIK3CA SERPINB5
5 lichen planopilaris 10.4 KRT14 KRT5
6 epidermolysis bullosa simplex, autosomal recessive 1 10.4 KRT14 KRT5
7 epidermolysis bullosa simplex, localized 10.4 KRT14 KRT5
8 epidermolysis bullosa simplex, generalized 10.4 KRT14 KRT5
9 breast cystic hypersecretory carcinoma 10.4 CDH1 KRT5
10 epidermolysis bullosa simplex with mottled pigmentation 10.4 KRT14 KRT5
11 spiradenoma 10.4 KRT14 KRT7
12 thyroid hurthle cell adenoma 10.3 KRT14 PIK3CA
13 inverted transitional papilloma 10.3 KRT5 KRT7
14 ceruminoma 10.3 KRT5 KRT7
15 benign mesothelioma 10.3 KRT5 KRT7
16 oncocytic breast carcinoma 10.3 KRT14 KRT7
17 odontoma 10.3 KRT14 KRT5
18 malignant acrospiroma 10.3 CEACAM5 KRT5
19 cervical adenoma malignum 10.3 KRT7 MME
20 breast benign neoplasm 10.3 KRT14 KRT5 MME
21 thoracic benign neoplasm 10.3 KRT14 KRT5 MME
22 myoepithelial carcinoma 10.3
23 hidradenoma 10.3 KRT7 PIK3CA
24 cervical mucinous adenocarcinoma 10.3 KRT7 MME
25 fibroepithelial basal cell carcinoma 10.2 CEACAM5 KRT14
26 clear cell papillary renal cell carcinoma 10.2 KRT7 MME
27 cervix endometriosis 10.2 CEACAM5 MME
28 large intestine adenocarcinoma 10.2 CDH1 KRT7
29 lipid-rich carcinoma 10.2 CDH1 KRT14 KRT5
30 linitis plastica 10.2 CDH1 KRT7
31 renal pelvis adenocarcinoma 10.2 CDH1 KRT7
32 malignant leydig cell tumor 10.2 KRT7 MME
33 pre-malignant neoplasm 10.2 CDH1 KRT14 KRT5
34 adenoid squamous cell carcinoma 10.2 CDH1 KRT7
35 breast squamous cell carcinoma 10.2 KRT14 KRT5 PIK3CA
36 brooke-spiegler syndrome 10.2 KRT14 KRT7
37 bladder lymphoma 10.2 KRT7 MME
38 adenomyoma 10.2 KRT7 MME
39 large cell acanthoma 10.2 KRT14 KRT5 KRT7
40 apocrine sweat gland neoplasm 10.2 KRT14 KRT5 KRT7
41 gastric diffuse adenocarcinoma 10.2 CDH1 KRT7
42 squamous cell carcinoma of the oral tongue 10.2 CDH1 PIK3CA
43 apocrine adenoma 10.2 CEACAM5 PIK3CA
44 sweat gland disease 10.2 KRT14 KRT5 KRT7
45 intraneural perineurioma 10.2 KRT14 KRT5 KRT7
46 goblet cell carcinoid 10.2 CDH1 ENO2
47 primary cutaneous amyloidosis 10.2 KRT14 KRT5 KRT7
48 cutaneous mucoepidermoid carcinoma 10.2 CEACAM5 KRT7
49 clear cell adenoma 10.2 CEACAM5 KITLG
50 balloon cell malignant melanoma 10.2 KRT5 KRT7 MME

Graphical network of the top 20 diseases related to Breast Adenomyoepithelioma:



Diseases related to Breast Adenomyoepithelioma

Symptoms & Phenotypes for Breast Adenomyoepithelioma

GenomeRNAi Phenotypes related to Breast Adenomyoepithelioma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 G0/1 arrest GR00098-A-2 9.02 ACIN1 CD99 CDH1 HSD11B2 KRT7

MGI Mouse Phenotypes related to Breast Adenomyoepithelioma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.61 CDH1 ENO2 HSD11B2 KITLG KRT14 KRT7
2 neoplasm MP:0002006 9.1 CDH1 HSD11B2 KITLG KRT14 PIK3CA PIK3R1

Drugs & Therapeutics for Breast Adenomyoepithelioma

Search Clinical Trials , NIH Clinical Center for Breast Adenomyoepithelioma

Genetic Tests for Breast Adenomyoepithelioma

Anatomical Context for Breast Adenomyoepithelioma

MalaCards organs/tissues related to Breast Adenomyoepithelioma:

42
Breast

Publications for Breast Adenomyoepithelioma

Articles related to Breast Adenomyoepithelioma:

# Title Authors Year
1
Breast adenomyoepithelioma and adenomyoepithelioma with carcinoma (malignant adenomyoepithelioma) with associated breast malignancies: A case series emphasizing histologic, radiologic, and clinical correlation. ( 27494340 )
2016
2
Breast Adenomyoepithelioma: Ultrasonography, Elastography, Digital Mammography, Contrast-Enhanced Digital Mammography, and Pathology Findings of This Rare Type of Breast Tumor. ( 26366690 )
2015
3
Breast adenomyoepithelioma: a case report with malignant proliferation of epithelial and myoepithelial elements. ( 24171817 )
2013
4
Fine-needle aspiration biopsy of breast adenomyoepithelioma: a potential false positive pitfall and presence of intranuclear cytoplasmic inclusions. ( 21548117 )
2012
5
Cytologic features of the tubular variant of breast adenomyoepithelioma. ( 11726113 )
2001

Variations for Breast Adenomyoepithelioma

Expression for Breast Adenomyoepithelioma

Search GEO for disease gene expression data for Breast Adenomyoepithelioma.

Pathways for Breast Adenomyoepithelioma

Pathways related to Breast Adenomyoepithelioma according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.54 CDH1 KITLG PIK3CA PIK3R1
2
Show member pathways
11.96 CD99 CEACAM5 PIK3CA PIK3R1
3
Show member pathways
11.84 CDH1 KITLG PIK3CA PIK3R1
4 11.75 CEACAM5 KITLG MME
5
Show member pathways
11.69 KRT14 KRT5 KRT7
6 11.63 ENO2 PIK3CA PIK3R1
7 11.48 CDH1 PIK3CA PIK3R1
8 11.22 CDH1 PIK3CA PIK3R1
9 11.07 HSD11B2 PIK3CA PIK3R1
10 10.95 PIK3CA PIK3R1
11 10.95 PIK3CA PIK3R1
12 10.95 CDH1 PIK3CA PIK3R1
13 10.92 PIK3CA PIK3R1
14 10.91 PIK3CA PIK3R1
15 10.82 CDH1 PIK3CA PIK3R1
16 10.81 PIK3CA PIK3R1
17 10.8 PIK3CA PIK3R1
18 10.77 PIK3CA PIK3R1
19 10.64 PIK3CA PIK3R1
20 10.53 CDH1 PIK3CA PIK3R1
21 10.08 CDH1 PIK3CA PIK3R1

GO Terms for Breast Adenomyoepithelioma

Cellular components related to Breast Adenomyoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.96 ACIN1 CD99 CDH1 CEACAM5 ENO2 KITLG
2 extracellular exosome GO:0070062 9.91 CDH1 CEACAM5 ENO2 KRT14 KRT5 KRT7
3 cytoplasm GO:0005737 9.73 CD99 CDH1 ENO2 HSD11B2 KITLG KRT14
4 keratin filament GO:0045095 9.33 KRT14 KRT5 KRT7
5 phosphatidylinositol 3-kinase complex GO:0005942 9.32 PIK3CA PIK3R1
6 phosphatidylinositol 3-kinase complex, class IA GO:0005943 8.62 PIK3CA PIK3R1

Biological processes related to Breast Adenomyoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol phosphorylation GO:0046854 9.33 KITLG PIK3CA PIK3R1
2 negative regulation of anoikis GO:2000811 9.26 CEACAM5 PIK3CA
3 cornification GO:0070268 9.13 KRT14 KRT5 KRT7
4 hemidesmosome assembly GO:0031581 8.62 KRT14 KRT5

Molecular functions related to Breast Adenomyoepithelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor substrate binding GO:0043560 8.96 PIK3CA PIK3R1
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.8 KITLG PIK3CA PIK3R1

Sources for Breast Adenomyoepithelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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