MCID: BRS004
MIFTS: 36

Breast Angiosarcoma

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Breast Angiosarcoma

MalaCards integrated aliases for Breast Angiosarcoma:

Name: Breast Angiosarcoma 12 20 15
Angiosarcoma of the Breast 20 44 70
Hemangiosarcoma of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4511
MeSH 44 C536368
NCIt 50 C5184
UMLS 70 C1332614

Summaries for Breast Angiosarcoma

Disease Ontology : 12 An angiosarcoma and sarcoma of breast and vascular neoplasm of breast that is located in the cells that line the blood vessels within the breast or underarm area.

MalaCards based summary : Breast Angiosarcoma, also known as angiosarcoma of the breast, is related to hemangioendothelioma and mesenchymal cell neoplasm. An important gene associated with Breast Angiosarcoma is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways are Tyrosine Kinases / Adaptors and MAPK Signaling: Mitogen Stimulation Pathway. Affiliated tissues include cells, breast and skin, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Breast Angiosarcoma

Diseases related to Breast Angiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
# Related Disease Score Top Affiliating Genes
1 hemangioendothelioma 30.2 FLT4 CD34
2 mesenchymal cell neoplasm 30.1 PECAM1 CD34
3 cavernous hemangioma 30.0 PECAM1 KDR CD34
4 hemangiopericytoma, malignant 29.9 PECAM1 CD34
5 vascular cancer 29.9 PECAM1 KDR FLT4 CD34
6 skin angiosarcoma 29.8 TIE1 SNRK FLT4
7 angiosarcoma 29.7 TIE1 PROX1 PECAM1 MYC KDR FLT4
8 lipomatosis, multiple 29.5 PECAM1 CD34
9 breast sarcoma 29.5 TIE1 SNRK PECAM1 NETO1 CD34
10 lymphangiosarcoma 28.9 TIE1 SNRK PROX1 PECAM1 FLT4 CD34
11 hemangioma 28.5 TIE1 PROX1 PECAM1 MYC KDR FLT4
12 lymphangioma 28.5 PROX1 PECAM1 MYC KDR FLT4 CD34
13 hemangioma-thrombocytopenia syndrome 10.3
14 skin epithelioid hemangioma 10.3 PECAM1 CD34
15 aortic malignant tumor 10.3 PECAM1 CD34
16 prostate angiosarcoma 10.3 PECAM1 CD34
17 central nervous system angiosarcoma 10.3 PECAM1 CD34
18 intravascular angioleiomyoma 10.3 PECAM1 CD34
19 central nervous system hemangioma 10.3 PECAM1 CD34
20 heart fibrosarcoma 10.3 PECAM1 CD34
21 ovarian angiosarcoma 10.3 PECAM1 CD34
22 conventional angiosarcoma 10.3 PECAM1 CD34
23 gallbladder leiomyosarcoma 10.3 PECAM1 CD34
24 thyroid sarcoma 10.3 PECAM1 CD34
25 pediatric angiosarcoma 10.3 PECAM1 CD34
26 angiomyoma 10.3 PECAM1 CD34
27 retroperitoneal hemangiopericytoma 10.3 PECAM1 CD34
28 glomangiosarcoma 10.3 PECAM1 CD34
29 breast hemangioma 10.3 PECAM1 CD34
30 hemangioma of spleen 10.3 PECAM1 CD34
31 liposarcoma of bone 10.3 PECAM1 CD34
32 colonic lymphangioma 10.3 PECAM1 CD34
33 liver leiomyoma 10.3 PECAM1 CD34
34 benign perivascular tumor 10.3 PECAM1 CD34
35 perivascular tumor 10.3 PECAM1 CD34
36 erythema elevatum diutinum 10.3 PECAM1 CD34
37 sarcomatoid squamous cell skin carcinoma 10.3 PECAM1 CD34
38 heart sarcoma 10.3 PECAM1 CD34
39 bacillary angiomatosis 10.3 PECAM1 CD34
40 pulmonary artery leiomyosarcoma 10.3 PECAM1 CD34
41 subungual glomus tumor 10.2 PECAM1 CD34
42 vulvar leiomyoma 10.2 PECAM1 CD34
43 thyroid angiosarcoma 10.2 PECAM1 CD34
44 intravascular fasciitis 10.2 PECAM1 CD34
45 glomeruloid hemangioma 10.2 PECAM1 CD34
46 liver angiosarcoma 10.2 SNRK PECAM1
47 histiocytoid hemangioma 10.2 PECAM1 CD34
48 glomangioma 10.2 PECAM1 CD34
49 glomangiomatosis 10.2 PECAM1 CD34
50 angiolipoma 10.2 PECAM1 CD34

Graphical network of the top 20 diseases related to Breast Angiosarcoma:



Diseases related to Breast Angiosarcoma

Symptoms & Phenotypes for Breast Angiosarcoma

GenomeRNAi Phenotypes related to Breast Angiosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.58 KDR MYC SNRK TIE1
2 Decreased viability GR00221-A-2 9.58 KDR SNRK
3 Decreased viability GR00221-A-3 9.58 KDR MYC
4 Decreased viability GR00221-A-4 9.58 KDR TIE1
5 Decreased viability GR00249-S 9.58 KDR MYC SNRK
6 Decreased viability GR00342-S-1 9.58 TIE1
7 Decreased viability GR00342-S-2 9.58 TIE1
8 Decreased viability GR00342-S-3 9.58 TIE1
9 Decreased viability GR00402-S-2 9.58 MYC SNRK

MGI Mouse Phenotypes related to Breast Angiosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.87 FLT4 KDR MYC PECAM1 PROX1 SNRK
2 immune system MP:0005387 9.86 CD34 FLT4 KDR MYC PECAM1 PROX1
3 integument MP:0010771 9.63 CD34 FLT4 KDR MYC SNRK TIE1
4 liver/biliary system MP:0005370 9.43 FLT4 KDR MYC PECAM1 PROX1 SNRK
5 muscle MP:0005369 9.17 FLT4 KDR MYC PECAM1 PROX1 SNRK

Drugs & Therapeutics for Breast Angiosarcoma

Search Clinical Trials , NIH Clinical Center for Breast Angiosarcoma

Cochrane evidence based reviews: angiosarcoma of the breast

Genetic Tests for Breast Angiosarcoma

Anatomical Context for Breast Angiosarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Breast Angiosarcoma:

19
Cells

MalaCards organs/tissues related to Breast Angiosarcoma:

40
Breast, Skin, Heart, Spleen, Bone, Liver, Thyroid

Publications for Breast Angiosarcoma

Articles related to Breast Angiosarcoma:

(show top 50) (show all 419)
# Title Authors PMID Year
1
MYC and NOTCH1-positive postradiation cutaneous angiosarcoma of the breast. 61
33527629 2021
2
Metastasis of primary breast angiosarcoma to axillary and supraclavicular lymph nodes: a rare case diagnosed using imaging data. 61
33784853 2021
3
Breast Angiosarcoma Surveillance Study: UK national audit of management and outcomes of angiosarcoma of the breast and chest wall. 61
33749771 2021
4
Magnetic resonance imaging and contrast-enhanced ultrasound findings of a recurrent primary breast angiosarcoma: A case report. 61
33592915 2021
5
Characteristics and Long-Term Risk of Breast Angiosarcoma. 61
33604827 2021
6
Secondary angiosarcoma following catheter-based brachytherapy. 61
33368859 2021
7
ASO Author Reflections: Breast Angiosarcoma-A Rare Disease with a Lot of Uncertainty. 61
33620617 2021
8
Radiation-associated angiosarcoma of the breast: analysis of diagnostic tools in a registry-based population. 61
33349000 2020
9
Primary High-Grade Angiosarcoma of the Breast in a Young Woman With Breast Implants: A Rare Case and a Review of Literature. 61
32423273 2020
10
Primary breast angiosarcoma in a postmenopausal female. 61
32808413 2020
11
Primary angiosarcoma of the breast with multifocal metastasis to contralateral breast: A diagnostic enigma. 61
32761703 2020
12
Angiosarcoma of the Breast: Management and Outcomes. 61
32889893 2020
13
Primary Breast Angiosarcoma: Utilisation of Pre-Surgical Magnetic Resonance Imaging (MRI) for Accurate Tumour Characterization and Planning - A Case Report and Literature Review. 61
33030134 2020
14
Radiation-Induced Cutaneous Angiosarcoma of the Breast. 61
32343946 2020
15
MRI of Primary Angiosarcoma of the Breast. 61
32720871 2020
16
A Case Report of Primary Breast Angiosarcoma: Clinical Presentation and Outcome After Adjuvant Radiotherapy. 61
33062971 2020
17
Sarcoma of the breast: breast cancer history as etiologic and prognostic factor-A population-based case-control study. 61
32696318 2020
18
Novel Body Composition Predictors of Outcome in Patients With Angiosarcoma of the Breast: A Preliminary Study. 61
32697532 2020
19
Giant primary angiosarcoma of an adolescent girl's breast diagnosed postmortem: a case report. 61
32591009 2020
20
Multidisciplinary approach to chest wall reconstruction in primary breast angiosarcoma resection. 61
32381526 2020
21
Primary angiosarcoma of the breast: Case report of a rare vascular tumor. 61
31993096 2020
22
Two cases of breast angiosarcoma after breast conserving surgery. 61
32337612 2020
23
Complete Response of a Pleural, Hepatic, and Splenic Metastatic Primary Breast Angiosarcoma Using Gemcitabine Monotherapy. 61
32069190 2020
24
Treatment and Prognosis of Radiation-Associated Breast Angiosarcoma in a Nationwide Population. 61
31773514 2020
25
ASO Author Reflections: Registry-Based Analysis of Radiation-Associated Angiosarcoma of the Breast Provides Unbiased Insights into this Disease. 61
31832919 2020
26
[Radiation-Induced Breast Angiosarcoma after Conservative Surgery for Breast Cancer]. 61
32381942 2020
27
Radiation-induced angiosarcoma of the breast: A review. 61
31448482 2020
28
Proper treatment of breast angiosarcoma-mastectomy or breast conserving surgery? 61
31848850 2020
29
The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research. 61
32042194 2020
30
Unusual Presentation of Bilateral Radiation-Induced Angiosarcoma of the Breast. 61
32190394 2020
31
Radiation-induced angiosarcoma: case report. 61
33295433 2020
32
Recurring radiation-induced angiosarcoma of the breast that was treated with paclitaxel chemotherapy: a case report. 61
31950295 2020
33
[Radiation-induced breast angiosarcoma: about a case]. 61
32774606 2020
34
Doxorubicin, paclitaxel, and cisplatin based chemotherapy for the treatment of angiosarcoma: Two case reports. 61
32120283 2020
35
Male Breast Cancer in Togo: Imaging and Clinicopathological Findings. 61
32934847 2020
36
Primary ovarian insufficiency associated with pazopanib therapy in a breast angiosarcoma patient: A CARE-compliant case report. 61
31852067 2019
37
Corrigendum to "Secondary breast angiosarcoma: A multicentre retrospective survey by the national Italian association of breast surgeons (ANISC)" [Breast 2019 56-60]. 61
31543291 2019
38
Primary and secondary breast angiosarcoma: single center report and a meta-analysis. 61
31522347 2019
39
Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma. 61
31570656 2019
40
Management trends and outcomes of breast angiosarcoma: Is breast conservation feasible? 61
31301088 2019
41
Recurrence of Primary Breast Angiosarcoma 7 Years after Mastectomy in a 17-Year-Old Woman: A Case Report. 61
31798394 2019
42
A case of primary breast angiosarcoma with multiple discontinuous small lesions. 61
31654286 2019
43
Revisiting the musculocutaneous external oblique flap as a versatile alternative in large thoracic wall defects. 61
31641891 2019
44
Angiosarcoma patients treated with immune checkpoint inhibitors: a case series of seven patients from a single institution. 61
31395100 2019
45
Early Breast Angiosarcoma Development After Radiotherapy: A Cautionary Tale. 61
31021840 2019
46
Primary angiosarcoma of the breast presenting with a benign vascular skin-like lesion and expanding hematoma: a case report of an extremely rare tumor. 61
31360438 2019
47
Primary angiosarcoma of the breast: a radiation oncologist's perspective with a concise review of the literature. 61
31324666 2019
48
A 27-year-old female presented with diffuse alveolar haemorrhage due to breast angiosarcoma with lung metastasis. 61
30956793 2019
49
Extent of resection and role of adjuvant treatment in resected localized breast angiosarcoma. 61
30820717 2019
50
Mammography and MRI manifestations of breast angiosarcoma. 61
31182098 2019

Variations for Breast Angiosarcoma

Expression for Breast Angiosarcoma

Search GEO for disease gene expression data for Breast Angiosarcoma.

Pathways for Breast Angiosarcoma

GO Terms for Breast Angiosarcoma

Cellular components related to Breast Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.35 TIE1 PECAM1 KDR FLT4 CD34
2 receptor complex GO:0043235 8.8 TIE1 KDR FLT4

Biological processes related to Breast Angiosarcoma according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.9 TIE1 SNRK KDR FLT4
2 protein phosphorylation GO:0006468 9.88 TIE1 SNRK KDR FLT4
3 angiogenesis GO:0001525 9.78 TIE1 KDR FLT4
4 positive regulation of protein phosphorylation GO:0001934 9.74 PECAM1 KDR FLT4
5 positive regulation of angiogenesis GO:0045766 9.73 TIE1 KDR CD34
6 peptidyl-tyrosine phosphorylation GO:0018108 9.71 TIE1 KDR FLT4
7 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.7 TIE1 KDR FLT4
8 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.59 KDR FLT4
9 ERK1 and ERK2 cascade GO:0070371 9.58 MYC KDR
10 positive regulation of kinase activity GO:0033674 9.58 TIE1 KDR FLT4
11 vascular endothelial growth factor signaling pathway GO:0038084 9.55 KDR FLT4
12 positive regulation of endothelial cell proliferation GO:0001938 9.54 PROX1 KDR FLT4
13 endothelial cell differentiation GO:0045446 9.51 PROX1 KDR
14 positive regulation of vasculogenesis GO:2001214 9.49 KDR CD34
15 lymphangiogenesis GO:0001946 9.48 PROX1 FLT4
16 lymph vessel development GO:0001945 9.46 PROX1 FLT4
17 vascular wound healing GO:0061042 9.43 KDR CD34
18 positive regulation of endothelial cell migration GO:0010595 9.43 PROX1 KDR FLT4
19 positive regulation of cell proliferation GO:0008284 9.35 PROX1 MYC MIR520H KDR FLT4
20 lymphatic endothelial cell differentiation GO:0060836 9.32 TIE1 PROX1
21 endothelium development GO:0003158 9.16 KDR CD34
22 glomerular endothelium development GO:0072011 8.62 PECAM1 CD34

Molecular functions related to Breast Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.62 TIE1 SNRK KDR FLT4
2 protein kinase activity GO:0004672 9.56 TIE1 SNRK KDR FLT4
3 protein tyrosine kinase activity GO:0004713 9.33 TIE1 KDR FLT4
4 vascular endothelial growth factor-activated receptor activity GO:0005021 8.96 KDR FLT4
5 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 TIE1 KDR FLT4

Sources for Breast Angiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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