MCID: BRS004
MIFTS: 38

Breast Angiosarcoma

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Breast Angiosarcoma

MalaCards integrated aliases for Breast Angiosarcoma:

Name: Breast Angiosarcoma 12 54 15
Angiosarcoma of the Breast 54 45 74
Hemangiosarcoma of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4511
MeSH 45 C536368
NCIt 51 C5184
UMLS 74 C1332614

Summaries for Breast Angiosarcoma

Disease Ontology : 12 An angiosarcoma and sarcoma of breast and vascular neoplasm of breast that is located in the cells that line the blood vessels within the breast or underarm area.

MalaCards based summary : Breast Angiosarcoma, also known as angiosarcoma of the breast, is related to angiosarcoma and radiation induced angiosarcoma of the breast. An important gene associated with Breast Angiosarcoma is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways are NF-kappaB Signaling and Melanocyte Development and Pigmentation. Affiliated tissues include breast, skin and lung, and related phenotypes are homeostasis/metabolism and cellular

Related Diseases for Breast Angiosarcoma

Diseases related to Breast Angiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 angiosarcoma 31.6 KIT PECAM1
2 radiation induced angiosarcoma of the breast 12.5
3 waardenburg syndrome type 4 10.3 MITF SOX10
4 waardenburg syndrome, type 2e 10.3 MITF SOX10
5 waardenburg syndrome, type 3 10.3 MITF SOX10
6 waardenburg syndrome, type 4b 10.3 MITF SOX10
7 cochlear disease 10.3 MITF SOX10
8 albinism, ocular, with sensorineural deafness 10.3 MITF TYR
9 waardenburg syndrome, type 4a 10.3 MITF SOX10
10 hypomelanosis of ito 10.3 MITF TYR
11 vitiligo-associated multiple autoimmune disease susceptibility 6 10.3 MITF TYR
12 peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease 10.2 MITF SOX10
13 pulmonary vein stenosis 10.2 KIT PECAM1
14 gallbladder melanoma 10.2 MITF MLANA
15 lentigo maligna melanoma 10.2 MITF MLANA
16 cutaneous ganglioneuroma 10.2 KIT MITF
17 halo nevi 10.2 MLANA TYR
18 melanoacanthoma 10.2 MLANA TYR
19 diffuse meningeal melanocytosis 10.2 MLANA TYR
20 small cell sarcoma 10.2 MLANA SOX10
21 hemangioma-thrombocytopenia syndrome 10.2
22 hermansky-pudlak syndrome 3 10.2 MITF TYR
23 albinism, oculocutaneous, type iv 10.2 MITF TYR
24 amelanotic melanoma 10.2 KIT TYR
25 hermansky-pudlak syndrome 1 10.1 SOX10 TYR
26 mucosal melanoma 10.1 KIT MITF
27 malignant anus melanoma 10.1 KIT MLANA
28 ovarian melanoma 10.1 KIT MLANA
29 breast cancer 10.1
30 breast secretory carcinoma 10.1 PGR SOX10
31 spinal meningioma 10.1 PGR SOX10
32 albinism, ocular, with late-onset sensorineural deafness 10.1 MITF SOX10 TYR
33 spinal canal and spinal cord meningioma 10.1 PGR SOX10
34 tietz albinism-deafness syndrome 10.1 MITF SOX10 TYR
35 vitiligo-associated multiple autoimmune disease susceptibility 1 10.1 MITF TYR
36 waardenburg syndrome, type 2a 10.1 MITF SOX10 TYR
37 waardenburg syndrome, type 1 10.1 MITF SOX10 TYR
38 dyschromatosis symmetrica hereditaria 10.1 MITF SOX10 TYR
39 sella turcica neoplasm 10.1 F8 PGR
40 tuberculum sellae meningioma 10.1 F8 PGR
41 ocular albinism 10.1 MITF TYR
42 kaposiform hemangioendothelioma 10.1 CD34 PECAM1
43 undifferentiated pleomorphic sarcoma 10.1 KIT MLANA
44 benign breast phyllodes tumor 10.1 KIT PGR
45 cribriform carcinoma 10.1 KIT PGR
46 adenoid basal cell carcinoma 10.1 KIT PGR
47 erythema elevatum diutinum 10.1 CD34 PECAM1
48 breast adenoid cystic carcinoma 10.0 KIT PGR
49 cystic nephroma 10.0 KIT PGR
50 perivascular epithelioid cell tumor 10.0 KIT PGR

Graphical network of the top 20 diseases related to Breast Angiosarcoma:



Diseases related to Breast Angiosarcoma

Symptoms & Phenotypes for Breast Angiosarcoma

MGI Mouse Phenotypes related to Breast Angiosarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.06 ANGPTL8 CD34 F8 KIT MITF PECAM1
2 cellular MP:0005384 9.98 CD34 KIT MITF PECAM1 PGR SOX10
3 immune system MP:0005387 9.91 CD34 F8 KIT MITF PECAM1 PGR
4 integument MP:0010771 9.87 CD34 KIT MITF MLANA PGR SOX10
5 limbs/digits/tail MP:0005371 9.65 KIT MITF PGR SOX10 TYR
6 neoplasm MP:0002006 9.55 CD34 KIT PGR SOX10 TYR
7 no phenotypic analysis MP:0003012 9.43 KIT MITF MLANA PGR SOX10 TYR
8 pigmentation MP:0001186 9.02 KIT MITF MLANA SOX10 TYR

Drugs & Therapeutics for Breast Angiosarcoma

Search Clinical Trials , NIH Clinical Center for Breast Angiosarcoma

Cochrane evidence based reviews: angiosarcoma of the breast

Genetic Tests for Breast Angiosarcoma

Anatomical Context for Breast Angiosarcoma

MalaCards organs/tissues related to Breast Angiosarcoma:

42
Breast, Skin, Lung, Ovary, Liver, Spleen, Small Intestine

The Foundational Model of Anatomy Ontology organs/tissues related to Breast Angiosarcoma:

20
The Cells

Publications for Breast Angiosarcoma

Articles related to Breast Angiosarcoma:

(show top 50) (show all 262)
# Title Authors Year
1
A Comparison of Outcomes and Prognostic Features for Radiation-Associated Angiosarcoma of the Breast and Other Radiation-Associated Sarcomas. ( 30703514 )
2019
2
Early appearance of post-radiation angiosarcoma of the breast. ( 30727036 )
2019
3
Extent of resection and role of adjuvant treatment in resected localized breast angiosarcoma. ( 30820717 )
2019
4
Secondary breast angiosarcoma: A multicentre retrospective survey by the national Italian association of Breast Surgeons (ANISC). ( 30877870 )
2019
5
Primary Epithelioid Angiosarcoma of the Breast: A Rare and Challenging Biopsy Diagnosis. ( 30940796 )
2019
6
Case of low-grade primary angiosarcoma of the breast with early recurrence. ( 30953382 )
2019
7
A 27-year-old female presented with diffuse alveolar haemorrhage due to breast angiosarcoma with lung metastasis. ( 30956793 )
2019
8
Early Breast Angiosarcoma Development After Radiotherapy: A Cautionary Tale. ( 31021840 )
2019
9
Radiation-induced angiosarcoma of the breast in a Li-Fraumeni patient. ( 30001797 )
2019
10
Primary and Secondary Breast Angiosarcoma: FDG PET/CT Series. ( 30371579 )
2019
11
Primary Angiosarcoma of the Breast after Bilateral Breast Reduction. ( 29977639 )
2018
12
Diagnostic difficulties of primary angiosarcoma of the breast: a case report. ( 30131065 )
2018
13
Repeated resection-associated breast angiosarcoma: A case report. ( 30278541 )
2018
14
A rare case of primary breast angiosarcoma in a male: a case report. ( 30326852 )
2018
15
Soft tissue angiosarcoma of the breast in a patient with Klippel-Trenaunay-Weber syndrome. ( 30361716 )
2018
16
Radiation-induced angiosarcoma of the breast: a retrospective analysis of 15 years' experience at an oncology center. ( 30369653 )
2018
17
Two cases of radiation-associated angiosarcoma of the breast. ( 30426313 )
2018
18
Management of Localized Breast Angiosarcoma by North American Radiation and Medical Oncologists. ( 30482726 )
2018
19
Primary breast angiosarcoma - a single institution experience from a tertiary cancer center in South India. ( 29286911 )
2018
20
First report of proton beam therapy for breast angiosarcoma from the prospective PCG registry. ( 29303019 )
2018
21
Impact of specialist management on survival from radiation-associated angiosarcoma of the breast. ( 29405251 )
2018
22
Primary angiosarcoma of the breast-series of 11 consecutive cases-a single-centre experience. ( 29507495 )
2018
23
Mutational landscape of radiation-associated angiosarcoma of the breast. ( 29515789 )
2018
24
Radiogenic angiosarcoma of the breast: case report and systematic review of the literature. ( 29690864 )
2018
25
Radiation-Associated Angiosarcoma of the Breast: A Case Report and Literature Review. ( 29805371 )
2018
26
Primary breast angiosarcoma in young women from the same geographic region in a short period of time: Only a coincidence or an increased risk? ( 28597488 )
2018
27
Radical chest wall resection and hyperfractionated accelerated radiotherapy for radiation-associated angiosarcoma of the breast: A safe and effective treatment strategy. ( 28845531 )
2018
28
Reduced H3K27me3 expression in radiation-associated angiosarcoma of the breast. ( 28983701 )
2018
29
Clinical outcomes in breast angiosarcoma patients: A rare tumor with unique challenges. ( 29205355 )
2017
30
Atypical Presentation of Radiation-Associated Breast Angiosarcoma: A Case Report and Review of Literature. ( 29249796 )
2017
31
Primary Synchronous Bilateral Angiosarcoma of the Breast. ( 29336740 )
2017
32
Prognosis and treatment of non-metastatic primary and secondary breast angiosarcoma: a comparative study. ( 28449661 )
2017
33
Breast angiosarcoma without radiation history, putatively associated with subclinical lymphedema: A case report and review of the Japanese literature. ( 28543441 )
2017
34
Clinicopathological features of breast angiosarcoma: A 16-years single-institution experience. ( 28704748 )
2017
35
Radiation induced angiosarcoma of the breast: outcomes from a retrospective case series. ( 28794852 )
2017
36
Primary breast angiosarcoma: a rare presentation of rare tumor - case report. ( 28855848 )
2017
37
Metastatic Primary Angiosarcoma of the Breast: Can We Tame It the Metronomic Way. ( 28900339 )
2017
38
Intensification of Treatment for Angiosarcoma of the Breast with Accelerated Hyperfractionated Radiation, Hyperthermia, and Surgical Resection. ( 30944783 )
2017
39
Primary Breast Angiosarcoma: A Retrospective Study of 36 Cases from a Single Chinese Medical Institute with Clinicopathologic and Radiologic Correlations. ( 27933680 )
2017
40
Primary Angiosarcoma of the Breast: A Case Report and Review of the Literature. ( 28234720 )
2017
41
Cutaneous Radiation-associated Breast Angiosarcoma: Radicality of Surgery Impacts Survival. ( 28267696 )
2017
42
Angiosarcoma of the Breast: A Rare and Dismal Complication of Breast Surgery Associated with Radiation. ( 28316292 )
2017
43
Breast Angiosarcoma with Exophytic Growth. ( 27845552 )
2016
44
Awareness of primary spontaneous hemorrhagic angiosarcoma of the breast associated with Kasabach-Merritt syndrome in a pregnant woman by enhanced magnetic resonance imaging: A CARE-compliant case report. ( 27858895 )
2016
45
Radiation-induced breast angiosarcoma: a case report. ( 28101140 )
2016
46
Radiation-Induced Breast Angiosarcoma: Case Report and Clinical Approach. ( 26848144 )
2016
47
Primary angiosarcoma of the breast. ( 26867719 )
2016
48
Multidisciplinary approach to breast angiosarcoma in an elderly patient: Repeated local relapses and significant objective responses. ( 26872968 )
2016
49
Exsanguinating Hemorrhage during Open Biopsy in a Primary Breast Angiosarcoma: A Case Report. ( 26989288 )
2016
50
Recurrent Primary Angiosarcoma of the Breast Presenting as Kasabach-Merritt Syndrome: A Case Report and Review of Literature. ( 27042570 )
2016

Variations for Breast Angiosarcoma

Expression for Breast Angiosarcoma

Search GEO for disease gene expression data for Breast Angiosarcoma.

Pathways for Breast Angiosarcoma

Pathways related to Breast Angiosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.77 CD34 KIT MLANA PECAM1
2 10.41 KIT MITF SOX10

GO Terms for Breast Angiosarcoma

Biological processes related to Breast Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.62 CD34 KIT MITF SOX10
2 cell maturation GO:0048469 9.4 ANGPTL8 SOX10
3 stem cell differentiation GO:0048863 9.37 KIT SOX10
4 paracrine signaling GO:0038001 9.26 CD34 PGR
5 glomerular endothelium development GO:0072011 9.16 CD34 PECAM1
6 pigmentation GO:0043473 9.13 KIT MITF TYR
7 melanocyte differentiation GO:0030318 8.8 KIT MITF SOX10

Sources for Breast Angiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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