MCID: BRS046
MIFTS: 26

Breast Benign Neoplasm

Categories: Cancer diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Breast Benign Neoplasm

MalaCards integrated aliases for Breast Benign Neoplasm:

Name: Breast Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060082
ICD10 33 D24

Summaries for Breast Benign Neoplasm

MalaCards based summary : Breast Benign Neoplasm is related to breast fibroadenoma and vulvar syringoma. An important gene associated with Breast Benign Neoplasm is PGR (Progesterone Receptor), and among its related pathways/superpathways are Thyroid hormone signaling pathway and Signaling by ERBB4. Affiliated tissues include breast, and related phenotypes are cardiovascular system and digestive/alimentary

Related Diseases for Breast Benign Neoplasm

Diseases in the Breast Cancer family:

Breast Benign Neoplasm Inflammatory Breast Carcinoma
Sporadic Breast Cancer Breast Carcinoma in Situ

Diseases related to Breast Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 breast fibroadenoma 29.9 ERBB2 ESR1 KRT14 KRT15 MED12 MME
2 vulvar syringoma 11.0 ESR1 PGR
3 lung leiomyoma 10.9 ESR1 PGR
4 scirrhous adenocarcinoma 10.9 ERBB2 PGR
5 breast apocrine carcinoma 10.9 ERBB2 PGR
6 vulvar benign neoplasm 10.9 ESR1 PGR
7 vulvar leiomyoma 10.9 ESR1 PGR
8 breast mucoepidermoid carcinoma 10.9 ERBB2 PGR
9 breast metaplastic carcinoma 10.9 ERBB2 PGR
10 intracystic papillary adenoma 10.9 ERBB2 PGR
11 progesterone-receptor negative breast cancer 10.9 ERBB2 PGR
12 endometrium carcinoma in situ 10.9 PGR TP53
13 progesterone resistance 10.9 ESR1 PGR
14 cribriform carcinoma 10.9 ESR1 PGR
15 comedo carcinoma 10.9 ERBB2 ESR1
16 endometrial squamous cell carcinoma 10.8 ESR1 PGR
17 endometrial clear cell adenocarcinoma 10.8 ESR1 TP53
18 bizarre leiomyoma 10.8 MED12 PGR
19 endometrial mucinous adenocarcinoma 10.8 ESR1 PGR
20 adenoid basal cell carcinoma 10.8 ESR1 PGR
21 gender identity disorder 10.8 ESR1 PGR
22 gallbladder squamous cell carcinoma 10.8 ERBB2 TP53
23 gastric papillary adenocarcinoma 10.8 ERBB2 TP53
24 female reproductive endometrioid cancer 10.8 PGR TP53
25 olfactory groove meningioma 10.8 PGR TP53
26 uterine corpus serous adenocarcinoma 10.8 ERBB2 TP53
27 estrogen excess 10.7 ESR1 PGR
28 mammographic density 10.7 ESR1 PGR
29 non-proliferative fibrocystic change of the breast 10.7 ERBB2 TP53
30 papillary serous adenocarcinoma 10.7 PGR TP53
31 retinitis pigmentosa 47 10.7 ESR1 PGR
32 glassy cell carcinoma of the cervix 10.7 ERBB2 ESR1 PGR
33 breast medullary carcinoma 10.7 ERBB2 ESR1 PGR
34 breast scirrhous carcinoma 10.7 ERBB2 ESR1 PGR
35 progesterone-receptor positive breast cancer 10.7 ERBB2 ESR1 PGR
36 pleomorphic adenoma carcinoma 10.7 ERBB2 TP53
37 apocrine adenocarcinoma 10.7 ERBB2 ESR1 PGR
38 breast adenoid cystic carcinoma 10.7 ERBB2 ESR1 PGR
39 luminal breast carcinoma 10.7 ERBB2 ESR1 PGR
40 inflammatory breast carcinoma 10.7 ERBB2 ESR1 PGR
41 mammary paget's disease 10.7 ERBB2 ESR1 PGR
42 bilateral breast cancer 10.7 ERBB2 ESR1 PGR
43 tubular adenocarcinoma 10.7 ERBB2 ESR1 PGR
44 anterior cranial fossa meningioma 10.7 PGR TP53
45 estrogen-receptor negative breast cancer 10.6 ERBB2 ESR1 PGR
46 glioma susceptibility 1 10.6 ERBB2 TP53
47 breast malignant phyllodes tumor 10.6 PGR PTS TP53
48 vestibular gland benign neoplasm 10.6 ESR1 PGR TP53
49 bartholin's gland adenoma 10.6 ESR1 PGR TP53
50 fallopian tube endometrioid adenocarcinoma 10.6 ERBB2 MME

Graphical network of the top 20 diseases related to Breast Benign Neoplasm:



Diseases related to Breast Benign Neoplasm

Symptoms & Phenotypes for Breast Benign Neoplasm

MGI Mouse Phenotypes related to Breast Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.01 PGR PIP ERBB2 PLVAP ESR1 PTS
2 digestive/alimentary MP:0005381 9.97 ERBB2 PIP PLVAP ESR1 PTS KRT14
3 homeostasis/metabolism MP:0005376 9.96 CD34 PGR ERBB2 PLVAP ESR1 PTS
4 endocrine/exocrine gland MP:0005379 9.92 PGR ERBB2 PIP PLVAP ESR1 PTS
5 integument MP:0010771 9.81 PGR CD34 ERBB2 PLVAP ESR1 PTS
6 limbs/digits/tail MP:0005371 9.43 PGR ERBB2 PLVAP ESR1 TP53 MED12
7 neoplasm MP:0002006 9.1 CD34 PGR ERBB2 ESR1 KRT14 TP53

Drugs & Therapeutics for Breast Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Breast Benign Neoplasm

Genetic Tests for Breast Benign Neoplasm

Anatomical Context for Breast Benign Neoplasm

MalaCards organs/tissues related to Breast Benign Neoplasm:

41
Breast

Publications for Breast Benign Neoplasm

Variations for Breast Benign Neoplasm

Expression for Breast Benign Neoplasm

Search GEO for disease gene expression data for Breast Benign Neoplasm.

Pathways for Breast Benign Neoplasm

Pathways related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.2 ESR1 MED12 TP53
2
Show member pathways
10.83 ERBB2 ESR1 PGR

GO Terms for Breast Benign Neoplasm

Biological processes related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular steroid hormone receptor signaling pathway GO:0030518 9.32 ESR1 MED12
2 replicative senescence GO:0090399 9.26 MME TP53
3 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.16 ESR1 TP53
4 positive regulation of gene expression GO:0010628 9.02 CD34 ERBB2 PIP RHOXF2 TP53
5 paracrine signaling GO:0038001 8.96 CD34 PGR

Molecular functions related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.47 ERBB2 ESR1 ING5 KRT14 KRT15 MED12
2 transcription factor binding GO:0008134 9.26 CD34 ESR1 MED12 TP53

Sources for Breast Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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