MCID: BRS046
MIFTS: 28

Breast Benign Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Breast Benign Neoplasm

MalaCards integrated aliases for Breast Benign Neoplasm:

Name: Breast Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060082
ICD10 34 D24

Summaries for Breast Benign Neoplasm

Disease Ontology : 12 A thoracic benign neoplasm that is characterized by lack of malignancy.

MalaCards based summary : Breast Benign Neoplasm is related to benign breast adenomyoepithelioma and breast neuroendocrine neoplasm. An important gene associated with Breast Benign Neoplasm is PGR (Progesterone Receptor), and among its related pathways/superpathways are Thyroid hormone signaling pathway and Signaling by ERBB4. Affiliated tissues include breast, and related phenotypes are cardiovascular system and cellular

Related Diseases for Breast Benign Neoplasm

Diseases related to Breast Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 202)
# Related Disease Score Top Affiliating Genes
1 benign breast adenomyoepithelioma 32.1 KRT14 KRT5
2 breast neuroendocrine neoplasm 32.0 ERBB2 PIP
3 breast myofibroblastoma 31.9 CD34 ESR1
4 breast fibroadenoma 31.6 ERBB2 ESR1 KRT14 MED12 PGR
5 breast lipoma 11.1
6 breast cyst 11.1
7 breast fibroadenosis 11.1
8 benign eccrine breast spiradenoma 11.1
9 breast leiomyoma 11.1
10 breast adenoma 11.1
11 benign breast phyllodes tumor 11.1
12 breast papillomatosis 11.1
13 nipple neoplasm 11.1
14 intraductal breast neoplasm 11.1
15 breast hemangioma 11.1
16 benign mammary dysplasia 11.1
17 retinitis pigmentosa 47 10.5 ESR1 PGR
18 mammographic density 10.5 ESR1 PGR
19 gender identity disorder 10.5 ESR1 PGR
20 estrogen excess 10.5 ESR1 PGR
21 endometrial mucinous adenocarcinoma 10.5 ESR1 PGR
22 adenoid basal cell carcinoma 10.5 ESR1 PGR
23 retroperitoneal leiomyosarcoma 10.5 PGR PTS
24 multiple enchondromatosis, maffucci type 10.5 IDH1 IDH2
25 intraductal papilloma 10.5 IDH1 IDH2
26 adult astrocytic tumour 10.5 IDH1 IDH2
27 pilocytic astrocytoma of cerebellum 10.5 IDH1 IDH2
28 spindle cell hemangioma 10.5 IDH1 IDH2
29 periosteal chondrosarcoma 10.5 IDH1 IDH2
30 vestibular gland benign neoplasm 10.5 ESR1 PGR
31 bartholin's gland adenoma 10.5 ESR1 PGR
32 scirrhous adenocarcinoma 10.4 ERBB2 PGR
33 vulvar syringoma 10.4 ESR1 PGR
34 lung leiomyoma 10.4 ESR1 PGR
35 breast apocrine carcinoma 10.4 ERBB2 PGR
36 vulvar benign neoplasm 10.4 ESR1 PGR
37 vulvar leiomyoma 10.4 ESR1 PGR
38 interval angle-closure glaucoma 10.4 IDH1 IDH2
39 intracystic papillary adenoma 10.4 ERBB2 PGR
40 adult oligodendroglioma 10.4 IDH1 IDH2
41 enchondroma 10.4 IDH1 IDH2
42 papillary serous adenocarcinoma 10.4 PGR TP53
43 anterior cranial fossa meningioma 10.4 PGR TP53
44 progesterone-receptor negative breast cancer 10.4 ERBB2 PGR
45 bartholin's gland benign neoplasm 10.4 ESR1 PGR
46 lymphoepithelioma-like thymic carcinoma 10.4 IDH1 KRT5
47 comedo carcinoma 10.4 ERBB2 ESR1
48 uterine corpus serous adenocarcinoma 10.4 ERBB2 TP53
49 mixed glioma 10.3 IDH1 TP53
50 endometrium carcinoma in situ 10.3 PGR TP53

Graphical network of the top 20 diseases related to Breast Benign Neoplasm:



Diseases related to Breast Benign Neoplasm

Symptoms & Phenotypes for Breast Benign Neoplasm

MGI Mouse Phenotypes related to Breast Benign Neoplasm:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.22 ERBB2 ESR1 IDH2 MED12 PGR PIP
2 cellular MP:0005384 10.16 CD34 ERBB2 ESR1 KRT14 MED12 PGR
3 growth/size/body region MP:0005378 10.16 ERBB2 ESR1 IDH1 KRT14 KRT5 MED12
4 endocrine/exocrine gland MP:0005379 10.13 ERBB2 ESR1 KRT14 PGR PIP PLVAP
5 digestive/alimentary MP:0005381 10.1 ERBB2 ESR1 KRT14 KRT5 PIP PLVAP
6 homeostasis/metabolism MP:0005376 10.1 CD34 ERBB2 ESR1 IDH1 KRT14 PGR
7 hematopoietic system MP:0005397 10.09 CD34 ESR1 IDH1 KRT14 PGR PIP
8 immune system MP:0005387 10.02 CD34 ESR1 IDH1 KRT14 PGR PIP
9 integument MP:0010771 9.97 CD34 ERBB2 ESR1 KRT14 KRT5 PGR
10 mortality/aging MP:0010768 9.9 ERBB2 ESR1 IDH1 KRT14 KRT5 MED12
11 limbs/digits/tail MP:0005371 9.8 ERBB2 ESR1 KRT5 MED12 PGR PLVAP
12 neoplasm MP:0002006 9.5 CD34 ERBB2 ESR1 IDH2 KRT14 PGR
13 respiratory system MP:0005388 9.1 ERBB2 ESR1 IDH1 KRT14 PLVAP TP53

Drugs & Therapeutics for Breast Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Breast Benign Neoplasm

Genetic Tests for Breast Benign Neoplasm

Anatomical Context for Breast Benign Neoplasm

MalaCards organs/tissues related to Breast Benign Neoplasm:

42
Breast

Publications for Breast Benign Neoplasm

Variations for Breast Benign Neoplasm

Expression for Breast Benign Neoplasm

Search GEO for disease gene expression data for Breast Benign Neoplasm.

Pathways for Breast Benign Neoplasm

Pathways related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 ESR1 MED12 TP53
2
Show member pathways
11.47 ERBB2 ESR1 PGR
3 11.05 KRT14 KRT5 TP53
4 10.61 ERBB2 IDH1 TP53
5
Show member pathways
10.27 IDH1 IDH2

GO Terms for Breast Benign Neoplasm

Cellular components related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.32 ERBB2 ESR1 IDH1 IDH2 KRT14 KRT5

Biological processes related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 2-oxoglutarate metabolic process GO:0006103 9.46 IDH1 IDH2
2 intracellular steroid hormone receptor signaling pathway GO:0030518 9.43 ESR1 MED12
3 hemidesmosome assembly GO:0031581 9.4 KRT14 KRT5
4 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.37 ESR1 TP53
5 positive regulation of gene expression GO:0010628 9.35 CD34 ERBB2 PIP RHOXF2 TP53
6 NADP metabolic process GO:0006739 9.32 IDH1 IDH2
7 paracrine signaling GO:0038001 9.26 CD34 PGR
8 isocitrate metabolic process GO:0006102 9.16 IDH1 IDH2
9 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.7 ERBB2 ESR1 IDH1 PGR PTS RHOXF2
2 transcription factor binding GO:0008134 9.56 CD34 ESR1 MED12 TP53
3 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
4 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Breast Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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