MCID: BRS046
MIFTS: 30

Breast Benign Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Breast Benign Neoplasm

MalaCards integrated aliases for Breast Benign Neoplasm:

Name: Breast Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060082
ICD10 32 D24

Summaries for Breast Benign Neoplasm

Disease Ontology : 12 A thoracic benign neoplasm that is characterized by lack of malignancy.

MalaCards based summary : Breast Benign Neoplasm is related to breast leiomyoma and breast myofibroblastoma. An important gene associated with Breast Benign Neoplasm is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include breast, lung and skin, and related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Breast Benign Neoplasm

Diseases related to Breast Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 514)
# Related Disease Score Top Affiliating Genes
1 breast leiomyoma 32.2 PGR MME CD34
2 breast myofibroblastoma 32.2 MME ESR1 CD34
3 breast cyst 32.2 SERPINA3 PRL PIP
4 breast hemangioma 32.2 TP53 KRT7 CD34
5 intraductal breast benign neoplasm 32.2 PGR MME KRT7 KRT5 KRT14 ESR1
6 nipple benign neoplasm 32.2 MME KRT7 KRT5
7 benign breast phyllodes tumor 32.1 PGR MME LCOR CD34
8 benign breast adenomyoepithelioma 31.9 KRT7 KRT5 KRT14 ESR1 EGFR
9 breast adenoma 31.8 PRL PRKAR1A PGR KRT14 ESR1
10 breast neuroendocrine neoplasm 31.8 PIP PGR KRT7 ESR1 ERBB2 CDH1
11 breast fibroadenoma 31.2 TP53 SERPINA3 PGR MME MED12 LCOR
12 breast lipoma 11.1
13 breast fibroadenosis 11.1
14 benign eccrine breast spiradenoma 11.1
15 breast papillomatosis 11.1
16 breast intraductal proliferative lesion 11.1
17 benign mammary dysplasia 11.1
18 chronic tympanitis 10.5 PGR ESR1
19 breast adenomyoepithelioma 10.5 KRT5 KRT14
20 granulomatous endometritis 10.5 PGR ESR1
21 diffuse peritoneal leiomyomatosis 10.5 PGR MED12
22 mucoepidermoid esophageal carcinoma 10.5 TP53 KRT5
23 lung leiomyoma 10.5 PGR ESR1
24 cervical adenomyoma 10.5 PGR MME
25 cervical benign neoplasm 10.5 PGR MME
26 leiomyomatosis 10.5 PGR MED12 ESR1
27 fallopian tube endometriosis 10.5 PGR MME
28 pulmonary vein leiomyosarcoma 10.5 PGR CD34
29 vulva basal cell carcinoma 10.5 KRT5 ERBB2
30 adult type testicular granulosa cell tumor 10.5 PGR ESR1
31 gastric papillary adenocarcinoma 10.5 TP53 ERBB2
32 laryngeal mucoepidermoid carcinoma 10.5 KRT14 ERBB2
33 congenital epulis 10.5 SERPINA3 PGR
34 glassy cell carcinoma of the cervix 10.5 PGR ESR1 ERBB2
35 breast intraductal papillomatosis 10.5 PGR ESR1 ERBB2
36 nipple carcinoma 10.5 PGR ESR1 ERBB2
37 lung meningioma 10.5 PGR CD34
38 benign pleural mesothelioma 10.5 TP53 CD34
39 fallopian tube clear cell adenocarcinoma 10.4 BRCA2 BRCA1
40 multifocal osteogenic sarcoma 10.4 TP53 CD34
41 urethral villous adenoma 10.4 PGR KRT7
42 pregnancy adenoma 10.4 PGR MED12 KRT5
43 cervical serous adenocarcinoma 10.4 PGR MME
44 breast adenoid cystic carcinoma 10.4 PGR ESR1 ERBB2
45 undifferentiated embryonal sarcoma of the liver 10.4 TP53 SERPINA3
46 ureter squamous cell carcinoma 10.4 KRT7 KRT5
47 cervix erosion 10.4 MME KRT5
48 bartholin's gland adenoma 10.4 TP53 PGR ESR1
49 bartholin's gland benign neoplasm 10.4 TP53 PGR ESR1
50 vestibular gland benign neoplasm 10.4 TP53 PGR ESR1

Graphical network of the top 20 diseases related to Breast Benign Neoplasm:



Diseases related to Breast Benign Neoplasm

Symptoms & Phenotypes for Breast Benign Neoplasm

MGI Mouse Phenotypes related to Breast Benign Neoplasm:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.37 BRCA1 BRCA2 CD34 CDH1 EGFR ERBB2
2 homeostasis/metabolism MP:0005376 10.28 BRCA1 BRCA2 CD34 CDH1 EGFR ERBB2
3 cardiovascular system MP:0005385 10.25 BRCA1 CDH1 EGFR ERBB2 ESR1 MED12
4 digestive/alimentary MP:0005381 10.22 BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1
5 endocrine/exocrine gland MP:0005379 10.21 BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1
6 immune system MP:0005387 10.21 BRCA1 BRCA2 CD34 CDH1 EGFR ESR1
7 integument MP:0010771 10.2 BRCA1 BRCA2 CD34 CDH1 EGFR ERBB2
8 embryo MP:0005380 10.16 BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1
9 neoplasm MP:0002006 9.93 BRCA1 BRCA2 CD34 CDH1 EGFR ERBB2
10 limbs/digits/tail MP:0005371 9.91 BRCA1 BRCA2 EGFR ERBB2 ESR1 KRT5
11 normal MP:0002873 9.65 BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1
12 reproductive system MP:0005389 9.4 BRCA1 BRCA2 CDH1 EGFR ERBB2 ESR1

Drugs & Therapeutics for Breast Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Breast Benign Neoplasm

Genetic Tests for Breast Benign Neoplasm

Anatomical Context for Breast Benign Neoplasm

MalaCards organs/tissues related to Breast Benign Neoplasm:

40
Breast, Lung, Skin, Liver, Ovary, Prostate, Cervix

Publications for Breast Benign Neoplasm

Articles related to Breast Benign Neoplasm:

# Title Authors PMID Year
1
Tubular Adenoma of the Breast: A Clinicopathologic Study of a Series of 9 Cases. 61
29449780 2018

Variations for Breast Benign Neoplasm

Expression for Breast Benign Neoplasm

Search GEO for disease gene expression data for Breast Benign Neoplasm.

Pathways for Breast Benign Neoplasm

Pathways related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.66 TP53 ERBB2 EGFR CDH1 BRCA2
2 12.64 TP53 ESR1 ERBB2 EGFR CDH1 BRCA2
3
Show member pathways
12.3 TP53 ESR1 ERBB2 EGFR CDH1 BRCA2
4
Show member pathways
12.15 PRKAR1A ESR1 ERBB2 EGFR
5 12.11 TP53 ESR1 ERBB2 EGFR
6 12 TP53 PRKAR1A EGFR CDH1
7 11.9 PGR KRT14 ESR1 EGFR
8
Show member pathways
11.89 TP53 PGR ESR1 ERBB2 EGFR CDH1
9
Show member pathways
11.69 PRL PGR ESR1 ERBB2 EGFR
10
Show member pathways
11.68 TP53 BRCA2 BRCA1
11 11.62 TP53 ESR1 EGFR CDH1 BRCA2 BRCA1
12 11.61 MME CDH1 CD34
13 11.6 TP53 ERBB2 BRCA1
14 11.58 TP53 PRL KRT5 KRT14
15 11.57 ERBB2 EGFR CDH1
16 11.56 TP53 ERBB2 EGFR
17 11.51 TP53 ERBB2 BRCA1
18 11.49 TP53 ERBB2 EGFR CDH1
19 11.07 ERBB2 EGFR CDH1

GO Terms for Breast Benign Neoplasm

Cellular components related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10 TP53 SERPINA3 PIP PGR MED12 LCOR
2 protein-containing complex GO:0032991 9.43 TP53 PRKAR1A ESR1 EGFR BRCA2 BRCA1
3 basal plasma membrane GO:0009925 8.8 ERBB2 EGFR CD34

Biological processes related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.93 TP53 PIP ERBB2 CD34 BRCA1
2 regulation of transcription by RNA polymerase II GO:0006357 9.81 TP53 PRKAR1A PGR MED12 LCOR ESR1
3 heart development GO:0007507 9.78 TP53 PRKAR1A MED12 ERBB2
4 double-strand break repair GO:0006302 9.63 TP53 BRCA2 BRCA1
5 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.52 TP53 ESR1
6 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.51 TP53 ESR1
7 positive regulation of transcription, DNA-templated GO:0045893 9.5 TP53 MED12 ESR1 EGFR CDH1 BRCA2
8 intracellular steroid hormone receptor signaling pathway GO:0030518 9.49 PGR ESR1
9 paracrine signaling GO:0038001 9.43 PGR CD34
10 cellular response to estradiol stimulus GO:0071392 9.43 LCOR ESR1 EGFR
11 negative regulation of ERBB signaling pathway GO:1901185 9.4 ERBB2 EGFR
12 cellular response to indole-3-methanol GO:0071681 9.37 CDH1 BRCA1
13 chordate embryonic development GO:0043009 9.32 BRCA2 BRCA1
14 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.8 TP53 BRCA2 BRCA1

Molecular functions related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.96 TP53 SERPINA3 PRL PRKAR1A PIP PGR
2 enzyme binding GO:0019899 9.55 TP53 PGR ESR1 EGFR BRCA1
3 identical protein binding GO:0042802 9.32 TP53 PIP PGR ESR1 ERBB2 EGFR
4 nitric-oxide synthase regulator activity GO:0030235 9.26 ESR1 EGFR

Sources for Breast Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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