MCID: BRS046
MIFTS: 30

Breast Benign Neoplasm

Categories: Cancer diseases, Endocrine diseases, Genetic diseases, Immune diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Breast Benign Neoplasm

MalaCards integrated aliases for Breast Benign Neoplasm:

Name: Breast Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060082
ICD10 33 D24

Summaries for Breast Benign Neoplasm

MalaCards based summary : Breast Benign Neoplasm is related to benign breast adenomyoepithelioma and breast neuroendocrine neoplasm. An important gene associated with Breast Benign Neoplasm is PGR (Progesterone Receptor), and among its related pathways/superpathways are Thyroid hormone signaling pathway and Signaling by ERBB4. Affiliated tissues include skin, lung and bone, and related phenotypes are digestive/alimentary and cardiovascular system

Related Diseases for Breast Benign Neoplasm

Diseases in the Breast Cancer family:

Breast Benign Neoplasm Inflammatory Breast Carcinoma
Sporadic Breast Cancer Breast Carcinoma in Situ

Diseases related to Breast Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
# Related Disease Score Top Affiliating Genes
1 benign breast adenomyoepithelioma 31.9 KRT14 KRT5
2 breast neuroendocrine neoplasm 31.9 ERBB2 PIP
3 benign breast phyllodes tumor 31.9 MME PGR
4 breast myofibroblastoma 31.5 CD34 ESR1 MME
5 breast fibroadenoma 31.1 ERBB2 ESR1 KRT14 KRT15 MED12 MME
6 breast lipoma 11.1
7 breast cyst 11.1
8 breast fibroadenosis 11.1
9 benign eccrine breast spiradenoma 11.1
10 breast leiomyoma 11.1
11 breast adenoma 11.1
12 breast papillomatosis 11.1
13 breast hemangioma 11.1
14 benign mammary dysplasia 11.1
15 retroperitoneal leiomyosarcoma 10.3 PGR PTS
16 mammographic density 10.3 ESR1 PGR
17 retinitis pigmentosa 47 10.3 ESR1 PGR
18 retinitis pigmentosa 20 10.3 ESR1 PGR
19 gender identity disorder 10.3 ESR1 PGR
20 estrogen excess 10.3 ESR1 PGR
21 scirrhous adenocarcinoma 10.3 ERBB2 PGR
22 breast apocrine carcinoma 10.3 ERBB2 PGR
23 papillary serous adenocarcinoma 10.3 PGR TP53
24 anterior cranial fossa meningioma 10.3 PGR TP53
25 vestibular gland benign neoplasm 10.3 ESR1 PGR
26 bartholin's gland adenoma 10.3 ESR1 PGR
27 glioma susceptibility 1 10.3 ERBB2 TP53
28 vulvar syringoma 10.3 ESR1 PGR
29 esophagus adenocarcinoma 10.3 ERBB2 TP53
30 uterine corpus serous adenocarcinoma 10.3 ERBB2 TP53
31 lung leiomyoma 10.3 ESR1 PGR
32 vulvar benign neoplasm 10.3 ESR1 PGR
33 vulvar leiomyoma 10.3 ESR1 PGR
34 intracystic papillary adenoma 10.3 ERBB2 PGR
35 progesterone-receptor negative breast cancer 10.3 ERBB2 PGR
36 endometrium carcinoma in situ 10.3 PGR TP53
37 bartholin's gland benign neoplasm 10.2 ESR1 PGR
38 comedo carcinoma 10.2 ERBB2 ESR1
39 bizarre leiomyoma 10.2 MED12 PGR
40 gastric papillary adenocarcinoma 10.2 ERBB2 TP53
41 endometrial stromal nodule 10.2 MME PGR
42 prostate squamous cell carcinoma 10.2 KRT5 TP53
43 perivascular epithelioid cell tumor 10.2 MME PGR
44 cystic nephroma 10.2 MME PGR
45 epidermolysis bullosa simplex, generalized 10.2 KRT14 KRT5
46 epidermolysis bullosa simplex with mottled pigmentation 10.2 KRT14 KRT5
47 glassy cell carcinoma of the cervix 10.2 ERBB2 ESR1 PGR
48 breast medullary carcinoma 10.2 ERBB2 ESR1 PGR
49 breast scirrhous carcinoma 10.2 ERBB2 ESR1 PGR
50 odontoma 10.2 KRT14 KRT5

Graphical network of the top 20 diseases related to Breast Benign Neoplasm:



Diseases related to Breast Benign Neoplasm

Symptoms & Phenotypes for Breast Benign Neoplasm

MGI Mouse Phenotypes related to Breast Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.02 ERBB2 ESR1 KRT14 KRT15 KRT5 PIP
2 cardiovascular system MP:0005385 10.01 ERBB2 ESR1 MED12 PGR PIP PLVAP
3 homeostasis/metabolism MP:0005376 9.96 CD34 ERBB2 ESR1 KRT14 KRT15 MME
4 endocrine/exocrine gland MP:0005379 9.92 ERBB2 ESR1 KRT14 PGR PIP PLVAP
5 integument MP:0010771 9.85 CD34 ERBB2 ESR1 KRT14 KRT5 MME
6 limbs/digits/tail MP:0005371 9.5 ERBB2 ESR1 KRT5 MED12 PGR PLVAP
7 neoplasm MP:0002006 9.1 CD34 ERBB2 ESR1 KRT14 PGR TP53

Drugs & Therapeutics for Breast Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Breast Benign Neoplasm

Genetic Tests for Breast Benign Neoplasm

Anatomical Context for Breast Benign Neoplasm

MalaCards organs/tissues related to Breast Benign Neoplasm:

41
Skin, Lung, Bone, Ovary, Prostate, Smooth Muscle

Publications for Breast Benign Neoplasm

Variations for Breast Benign Neoplasm

Expression for Breast Benign Neoplasm

Search GEO for disease gene expression data for Breast Benign Neoplasm.

Pathways for Breast Benign Neoplasm

Pathways related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 ESR1 MED12 TP53
2
Show member pathways
11.17 ERBB2 ESR1 PGR
3 10.71 KRT14 KRT5 TP53

GO Terms for Breast Benign Neoplasm

Biological processes related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.58 KRT14 KRT15 KRT5
2 epidermis development GO:0008544 9.54 KRT14 KRT15 KRT5
3 intracellular steroid hormone receptor signaling pathway GO:0030518 9.43 ESR1 MED12
4 replicative senescence GO:0090399 9.32 MME TP53
5 hemidesmosome assembly GO:0031581 9.26 KRT14 KRT5
6 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.16 ESR1 TP53
7 positive regulation of gene expression GO:0010628 9.02 CD34 ERBB2 PIP RHOXF2 TP53
8 paracrine signaling GO:0038001 8.96 CD34 PGR

Molecular functions related to Breast Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.62 ESR1 ING5 MED12 TP53
2 transcription factor binding GO:0008134 9.56 CD34 ESR1 MED12 TP53
3 protein binding GO:0005515 9.47 ERBB2 ESR1 ING5 KRT14 KRT15 KRT5
4 identical protein binding GO:0042802 9.43 ERBB2 ESR1 PGR PTS RHOXF2 TP53
5 structural constituent of cytoskeleton GO:0005200 9.33 KRT14 KRT15 KRT5

Sources for Breast Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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