MCID: BRS049
MIFTS: 50

Breast Carcinoma in Situ

Categories: Cancer diseases, Genetic diseases, Immune diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Breast Carcinoma in Situ

MalaCards integrated aliases for Breast Carcinoma in Situ:

Name: Breast Carcinoma in Situ 12 43 15
Carcinoma in Situ of Breast 12 32
Non-Infiltrating Carcinoma of Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8791
ICD9CM 34 233.0
MeSH 43 D000071960
ICD10 32 D05 D05.9
UMLS 71 C0154084

Summaries for Breast Carcinoma in Situ

Disease Ontology : 12 An in situ carcinoma that is located in the breast.

MalaCards based summary : Breast Carcinoma in Situ, also known as carcinoma in situ of breast, is related to ductal carcinoma in situ and lobular neoplasia. An important gene associated with Breast Carcinoma in Situ is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Signaling by GPCR and Apoptotic Pathways in Synovial Fibroblasts. The drugs Medroxyprogesterone acetate and mometasone furoate have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and testes, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Breast Carcinoma in Situ

Diseases in the Breast Cancer family:

Inflammatory Breast Carcinoma Sporadic Breast Cancer
Breast Carcinoma in Situ

Diseases related to Breast Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 243)
# Related Disease Score Top Affiliating Genes
1 ductal carcinoma in situ 33.4 VEGFA TP53 ERBB2 BRCA2 BRCA1
2 lobular neoplasia 33.3 TP53 ERBB2 CT45A10 BRCA2 BRCA1
3 comedo carcinoma 33.1 TP53 ERBB2
4 in situ carcinoma 31.9 TP53 ERBB2 CT45A10 BRCA2 BRCA1
5 breast ductal carcinoma 31.1 VEGFC VEGFA TP53 MET KRT19 ERBB2
6 female breast cancer 30.7 TP53 ERBB2 BRCA2 BRCA1
7 breast fibroadenoma 30.6 VEGFC TP53 ERBB2 CT45A10 BRCA1
8 breast disease 30.5 VEGFA TP53 KRT19 ERBB2 BRCA2 BRCA1
9 breast cancer 30.5 VEGFC VEGFA TP53 STS MET KRT19
10 neuroblastoma 30.1 VEGFA TP53 MET KDR IL6 FGFR1
11 ovarian cancer 29.7 VEGFC VEGFA TP53 MET KDR IL6
12 breast apocrine carcinoma in situ 12.0
13 hereditary site-specific ovarian cancer syndrome 10.8 BRCA2 BRCA1
14 rare malignant breast tumor 10.7 BRCA2 BRCA1
15 synchronous bilateral breast carcinoma 10.7 BRCA2 BRCA1
16 breast juvenile papillomatosis 10.7 ERBB2 BRCA2 BRCA1
17 septate uterus 10.7 KDR FLT1
18 endosalpingiosis 10.7 TP53 BRCA2 BRCA1
19 gastric papillary adenocarcinoma 10.7 TP53 ERBB2
20 mutagen sensitivity 10.7 TP53 BRCA2 BRCA1
21 familial ovarian cancer 10.7 BRCA2 BRCA1
22 intracystic papillary adenoma 10.7 ERBB2 BRCA2 BRCA1
23 tetraploidy 10.7 BRCA2 BRCA1
24 cancerophobia 10.7 BRCA2 BRCA1
25 uterine corpus serous adenocarcinoma 10.7 TP53 ERBB2 BRCA1
26 hemifacial spasm 10.7 VEGFA FLT4
27 papillary serous adenocarcinoma 10.7 TP53 BRCA2 BRCA1
28 nosophobia 10.7 BRCA2 BRCA1
29 pediatric angiosarcoma 10.7 VEGFA TP53
30 angiokeratoma of mibelli 10.7 KDR FLT1
31 myasthenic syndrome, congenital, 6, presynaptic 10.7 TP53 BRCA2 BRCA1
32 breast squamous cell carcinoma 10.7 TP53 ERBB2
33 radiation proctitis 10.7 VEGFA KDR FGF2
34 proctitis 10.7 VEGFA KDR FGF2
35 bilateral breast cancer 10.7 ERBB2 BRCA2 BRCA1
36 gastroesophageal junction adenocarcinoma 10.7 VEGFA KDR ERBB2
37 osteosclerotic myeloma 10.7 VEGFA IL6
38 sweat gland cancer 10.7 TP53 KRT19 ERBB2
39 breast sarcoma 10.7 TP53 FLT4 ERBB2
40 luminal breast carcinoma 10.7 TP53 ERBB2 BRCA1
41 hypertrophy of breast 10.7 TP53 ERBB2 BRCA2 BRCA1
42 peritoneum cancer 10.7 TP53 ERBB2 BRCA2 BRCA1
43 female reproductive endometrioid cancer 10.7 TP53 ERBB2 BRCA2 BRCA1
44 angiokeratoma circumscriptum 10.7 VEGFA KDR FLT1
45 apocrine adenosis of breast 10.7 TP53 ERBB2
46 decubitus ulcer 10.7 VEGFA IL6 FGF2
47 gastroesophageal adenocarcinoma 10.7 MET KDR ERBB2
48 epithelioid hemangioendothelioma 10.7 VEGFA KDR FLT1
49 background diabetic retinopathy 10.7 VEGFA KDR IL6
50 vitreous disease 10.7 VEGFA IL6 FGF2

Graphical network of the top 20 diseases related to Breast Carcinoma in Situ:



Diseases related to Breast Carcinoma in Situ

Symptoms & Phenotypes for Breast Carcinoma in Situ

GenomeRNAi Phenotypes related to Breast Carcinoma in Situ according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.6 FGFR1 KDR
2 Decreased viability GR00221-A-2 9.6 BRCA1 FGFR1 FLT1 FLT4 KDR
3 Decreased viability GR00221-A-3 9.6 BRCA1 KDR
4 Decreased viability GR00221-A-4 9.6 KDR
5 Decreased viability GR00301-A 9.6 BRCA1
6 Decreased viability GR00342-S-1 9.6 FLT4
7 Decreased viability GR00342-S-2 9.6 FLT4
8 Decreased viability GR00342-S-3 9.6 FLT4
9 Decreased viability GR00402-S-2 9.6 BRCA1 FGFR1 FLT1 FLT4 KDR
10 Decreased cell migration GR00055-A-1 9.55 FLT1 KDR MET SDC1 VEGFC
11 Decreased substrate adherent cell growth GR00193-A-1 9.35 MET
12 Decreased substrate adherent cell growth GR00193-A-3 9.35 MET
13 Decreased substrate adherent cell growth GR00193-A-4 9.35 FGFR1 KDR MET

MGI Mouse Phenotypes related to Breast Carcinoma in Situ:

45 (show all 24)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.49 BRCA1 CLDN4 ERBB2 FGF2 FGFR1 FLT1
2 cellular MP:0005384 10.48 BRCA1 BRCA2 CLDN4 ERBB2 FGF2 FGFR1
3 homeostasis/metabolism MP:0005376 10.48 BRCA1 BRCA2 CLDN4 ERBB2 FGF2 FGFR1
4 growth/size/body region MP:0005378 10.41 BRCA1 BRCA2 CLDN4 ERBB2 FGFR1 FLT1
5 immune system MP:0005387 10.41 BRCA1 BRCA2 FGFR1 FLT1 FLT4 IL6
6 mortality/aging MP:0010768 10.41 BRCA1 BRCA2 CLDN4 ERBB2 FGF2 FGFR1
7 behavior/neurological MP:0005386 10.4 BRCA1 BRCA2 ERBB2 FGF2 FGFR1 FLT1
8 hematopoietic system MP:0005397 10.37 BRCA1 BRCA2 CLDN4 FGF2 FGFR1 FLT1
9 embryo MP:0005380 10.36 BRCA1 BRCA2 ERBB2 FGFR1 FLT1 FLT4
10 integument MP:0010771 10.34 BRCA1 BRCA2 ERBB2 FGFR1 FLT4 IL6
11 digestive/alimentary MP:0005381 10.33 BRCA1 BRCA2 ERBB2 FGFR1 FLT4 IL6
12 endocrine/exocrine gland MP:0005379 10.32 BRCA1 BRCA2 ERBB2 FGFR1 IL6 IL6ST
13 nervous system MP:0003631 10.25 BRCA1 BRCA2 ERBB2 FGF2 FGFR1 FLT1
14 muscle MP:0005369 10.2 BRCA1 ERBB2 FGF2 FGFR1 FLT1 FLT4
15 neoplasm MP:0002006 10.17 BRCA1 BRCA2 ERBB2 FGF2 IL6 IL6ST
16 craniofacial MP:0005382 10.14 ERBB2 FGFR1 KDR KRT19 MET TP53
17 normal MP:0002873 10.13 BRCA1 BRCA2 CLDN4 ERBB2 FGFR1 FLT1
18 limbs/digits/tail MP:0005371 10.11 BRCA1 BRCA2 ERBB2 FGFR1 IL6ST MET
19 liver/biliary system MP:0005370 10.1 FLT4 IL6 IL6ST KDR KRT19 MET
20 reproductive system MP:0005389 10.07 BRCA1 BRCA2 ERBB2 FGF2 FGFR1 FLT1
21 no phenotypic analysis MP:0003012 9.91 FGFR1 FLT4 KDR KRT19 MET TP53
22 respiratory system MP:0005388 9.76 BRCA1 ERBB2 IL6 KDR KRT19 MET
23 skeleton MP:0005390 9.7 BRCA1 BRCA2 ERBB2 FGF2 FGFR1 IL6
24 vision/eye MP:0005391 9.32 FGF2 FGFR1 FLT1 IL6 IL6ST KDR

Drugs & Therapeutics for Breast Carcinoma in Situ

Drugs for Breast Carcinoma in Situ (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 145)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Medroxyprogesterone acetate Approved, Investigational Phase 3 71-58-9
2
mometasone furoate Approved, Investigational, Vet_approved Phase 3 83919-23-7
3
Oxybutynin Approved, Investigational Phase 3 5633-20-5 4634
4
Metformin Approved Phase 3 657-24-9 14219 4091
5
Pembrolizumab Approved Phase 3 1374853-91-4
6
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
7
Trastuzumab Approved, Investigational Phase 3 180288-69-1 9903
8 Neurotransmitter Agents Phase 3
9 Contraceptive Agents Phase 3
10 Contraceptives, Oral Phase 3
11 Contraceptive Agents, Male Phase 3
12
Medroxyprogesterone Phase 3 520-85-4 10631
13 Dermatologic Agents Phase 3
14 Anti-Allergic Agents Phase 3
15 Renal Agents Phase 3
16 Autonomic Agents Phase 3
17 Mandelic Acids Phase 3
18 Anti-Infective Agents, Urinary Phase 3
19 Muscarinic Antagonists Phase 3
20 Cholinergic Antagonists Phase 3
21 Cholinergic Agents Phase 3
22 Parasympatholytics Phase 3
23 Hypoglycemic Agents Phase 3
24 Immunologic Factors Phase 3
25 Antibodies Phase 3
26 Immunoglobulins Phase 3
27 Antineoplastic Agents, Immunological Phase 3
28 Antibodies, Monoclonal Phase 3
29 Progestins Phase 3
30
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
31
Epirubicin Approved Phase 2 56420-45-2 41867
32
Bevacizumab Approved, Investigational Phase 2 216974-75-3
33
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
34
Vinorelbine Approved, Investigational Phase 2 71486-22-1 60780 44424639
35
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
36
Curcumin Approved, Experimental, Investigational Phase 2 458-37-7 969516
37
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757
38
Polyestradiol phosphate Approved Phase 2 28014-46-2
39
Simvastatin Approved Phase 2 79902-63-9 54454
40
Ethanol Approved Phase 2 64-17-5 702
41
Naltrexone Approved, Investigational, Vet_approved Phase 2 16590-41-3 5360515
42
Bazedoxifene Approved, Investigational Phase 2 198481-32-2
43
Iodine Approved, Investigational Phase 2 7553-56-2 807
44
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
45
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
46
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
47
St. John's Wort Approved, Investigational, Nutraceutical Phase 2 84082-80-4
48
Sulforaphane Investigational Phase 2 142825-10-3, 4478-93-7 5350
49
Afimoxifene Investigational Phase 2 68392-35-8
50 Anti-Bacterial Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 167)
# Name Status NCT ID Phase Drugs
1 An Investigator Initiated Registry of Simple Oral Therapy for Low Risk Breast Cancer (SOLR) Withdrawn NCT03238703 Phase 4 Anastrozole;Exemestane;Letrozole;Tamoxifen Citrate;Toremifene Citrate
2 Optimal Wound Care After Simplex or Modified Radical Mastectomy With or Without Axillary Lymphadenectomy Placement of a Drain Versus the Use of Adaptive Skin Sutures; a Prospective Randomised Study Unknown status NCT01509781 Phase 3
3 A Randomized Comparison Of Medroxyprogesterone Acetate (MA) And Observation For Prevention Of Endometrial Pathology In Postmenopausal Breast Cancer Patients Treated With Tamoxifen, Phase III Completed NCT00002920 Phase 3 medroxyprogesterone;tamoxifen citrate
4 Phase III Randomized Double-Blind Study of Mometasone Furoate Versus Placebo in the Prevention of Radiation Dermatitis in Breast Cancer Patients Receiving Radiation Therapy Completed NCT00438659 Phase 3 mometasone furoate
5 Genetic Counseling for Newly Diagnosed Breast Cancer Patients Completed NCT00262899 Phase 3
6 A Phase III Study to Evaluate Letrozole as Adjuvant Endocrine Therapy for Postmenopausal Women With Receptor (ER and/or PgR) Positive Tumors Completed NCT00004205 Phase 3 letrozole;tamoxifen citrate
7 A Phase III, Double-Blind, Controlled Trial of Oxybutynin in the Management of Hot Flashes Completed NCT02961790 Phase 3 Oxybutynin Chloride
8 A Clinical Trial Comparing Anastrozole With Tamoxifen in Postmenopausal Patients With Ductal Carcinoma in Situ (DCIS) Undergoing Lumpectomy With Radiation Therapy Completed NCT00053898 Phase 3 anastrozole;tamoxifen citrate
9 Testing for Atypia in Random Periareolar Fine Needle Aspiration (RPFNA) Cytology After 12 Months Metformin (1, 1-Dimethylbiguanide Hydrochloride) Chemoprevention Versus Placebo Control in Premenopausal Women Recruiting NCT01905046 Phase 3 metformin hydrochloride
10 A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer With >/= 1 CM Residual Invasive Cancer or Positive Lymph Nodes (ypN+) After Neoadjuvant Chemotherapy Recruiting NCT02954874 Phase 3
11 Radiotherapy Versus Low-Dose Tamoxifen Following Breast Conserving Surgery for Low-Risk and Estrogen Receptor-Positive Ductal Carcinoma in Situ of Breast: an International Open-label Randomized Non-inferiority Trial Recruiting NCT04046159 Phase 3 Low-dose tamoxifen
12 A Multicentric Phase III Trial Evaluating the Impact of a Radiation Boost (16Gy) After Breast Conserving Surgery and a Whole Breast Irradiation (50Gy) for DCIS Active, not recruiting NCT00907868 Phase 3
13 A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently With Radiation Therapy and Radiation Therapy Alone for Women With HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy Active, not recruiting NCT00769379 Phase 3
14 International Breast Cancer Intervention Study II (IBIS-II) (DCIS) Active, not recruiting NCT00072462 Phase 3 tamoxifen citrate;Anastrozole
15 Phase III Trial of Tamoxifen Alone vs. Tamoxifen Plus Radiation Therapy for Good Risk Duct Carcinoma In-Situ (DCIS) of the Female Breast Active, not recruiting NCT00003857 Phase 3 tamoxifen citrate
16 A Phase III, Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients With 1-3 Positive Nodes, Hormone Receptor-Positive and HER2-Negative Breast Cancer With Recurrence Score (RS) of 25 or Less. RxPONDER: A Clinical Trial Rx for Positive Node, Endocrine Responsive Breast Cancer Active, not recruiting NCT01272037 Phase 3 Anastrozole;Exemestane;Letrozole;Systemic Chemotherapy;Tamoxifen Citrate
17 A Phase III Trial of Accelerated Whole Breast Irradiation With Hypofractionation Plus Concurrent Boost Versus Standard Whole Breast Irradiation Plus Sequential Boost for Early-Stage Breast Cancer Active, not recruiting NCT01349322 Phase 3
18 A Randomised, Double-Blind Trial to Assess the Effects on Bone Mineral Density and Bone Biomarkers of Anastrozole When Used to Prevent Breast Cancer in Postmenopausal Women Withdrawn NCT00324714 Phase 3 risedronate sodium
19 A Multicenter Phase II Study of Docosahexaenoic Acid (DHA) in Patients With a History of Breast Cancer, Premalignant Lesions, or Benign Breast Disease Unknown status NCT01849250 Phase 2 Docosahexaenoic Acid
20 Randomised Trial Testing Observation (No Radiotherapy) Against Radiotherapy In Women With Low-Risk Completely Excised ER Positive Ductal Carcinoma In Situ (DCIS) Of The Breast On Adjuvant Endocrine Therapy Unknown status NCT00077168 Phase 2 anastrozole;tamoxifen citrate
21 "Phase II Study of PET Guided Neoadjuvant Chemotherapy (NAC) and Oncotype Guided Hormonal Therapy of Breast Cancer" Unknown status NCT01641406 Phase 2 Docetaxel, Epirubicin, Cyclophosphamide/Navelbine, Capecitabine, Trastuzumab, Bevacizumab;Docetaxel, Epirubicin, Cyclophosphamide/Navelbine, Capecitabine, Trastuzumab, Bevacizumab;Docetaxel, Epirubicin, Cyclophosphamide/Navelbine, Capecitabine, Trastuzumab, Bevacizumab
22 Ten Years Results of a Score System to Address Adjuvant Therapies After Breast Conserving Surgery for Ductal Carcinoma in Situ of the Breast. Completed NCT03002766 Phase 2
23 Effectiveness of Prophylactic Topical Agents for Radiation Dermatitis Completed NCT02556632 Phase 2 Curcumin-based Gel
24 A Randomized, Placebo-Controlled Phase II Clinical Trial of Omega-3 PUFA Dietary Supplementation in Patients With Stage I-III Breast Carcinoma Completed NCT01869764 Phase 2 omega-3 fatty acid
25 Phase II Study of Soy Protein to Treat Vasomotor Symptoms in Postmenopausal Women Taking Tamoxifen Completed NCT00031720 Phase 2 Tamoxifen
26 A Randomized Trial to Explore the Effect of Oral Omega 3 Fatty Acids on Atrophic Vaginitis in Postmenopausal Breast Cancer Survivors Completed NCT02150525 Phase 2
27 Validating CYP2D6 Genotype-Guided Tamoxifen Therapy for a Multiracial U.S. Population Completed NCT00764322 Phase 2 tamoxifen citrate
28 Sulforaphane: A Dietary Histone Deacetylase (HDAC) Inhibitor in Ductal Carcinoma in Situ (DCIS) Completed NCT00843167 Phase 2
29 Intraoperative Radiation Therapy to the Tumor Bed for Boost Treatment After Lumpectomy Prior to Whole Breast Radiation in Breast Conservation Candidates Completed NCT00054301 Phase 2
30 A Pilot Study of Aromatase Inhibitors for Women at Increased Risk of Breast Cancer Based on Estradiol Levels Completed NCT00090857 Phase 2 Letrozole
31 Surrogate Markers of Response: A Phase II Study of Changes in Breast Density Among Postmenopausal Women Receiving Adjuvant Anastrozole Therapy Completed NCT00244959 Phase 2 anastrozole
32 A Trial Assessing the Effect of Simvastatin on the Pharmacokinetics of Anastrozole Completed NCT00354640 Phase 2 anastrozole;simvastatin
33 Naltrexone Randomized Controlled Trial for Treatment-Emergent Fatigue in Patients Receiving Radiation Therapy for Breast Cancer Completed NCT02137252 Phase 2 Naltrexone;Sugar Pill
34 Pre-surgical Phase IIb Trial of Transdermal 4-Hydroxytamoxifen vs. Oral Tamoxifen in Women With Ductal Carcinoma in Situ of the Breast Completed NCT00952731 Phase 2 oral placebo;afimoxifene;tamoxifen citrate;placebo gel
35 Randomized Phase II Biomarker Pilot Trial of Fluvastatin Use in Women With Ductal Carcinoma in Situ (DCIS) or Stage I Breast Cancer Completed NCT00416403 Phase 2 fluvastatin sodium
36 A Phase II Study of Simvastatin in Women at High Risk for a New Breast Cancer Completed NCT00334542 Phase 2 simvastatin
37 Phase II Study of Neoadjuvant Letrozole for Postmenopausal Women With Estrogen Receptor Positive Ductal Carcinoma In SITU (DCIS) Completed NCT01439711 Phase 2 letrozole
38 NOVEMBER (Novem- (9), BrEast Radiation), A Phase II Trial of a 9 Day Course of Whole Breast Radiotherapy for Early Stage Breast Cancer Recruiting NCT03345420 Phase 2
39 TBCRC 042 - A Randomized Phase II Window-of-Opportunity Trial of Ruxolitinib in Patients With High Risk and Premalignant Breast Conditions Recruiting NCT02928978 Phase 2 Ruxolitinib;Placebo (for Ruxolitinib)
40 Phase IIB Pre-Surgical Trial of Oral Tamoxifen Versus Transdermal 4-hydroxytamoxifen in Women With DCIS of the Breast Recruiting NCT02993159 Phase 2 Afimoxifene;Tamoxifen Citrate
41 Assessing the Cosmesis and Toxicity of Partial Breast Irradiation Using Proton Beam Irradiation Recruiting NCT01245712 Phase 2
42 Utilization of Telehealth to Improve Adherence to Adjuvant Endocrine Therapy in Breast Cancer Patients Recruiting NCT04054557 Phase 2
43 A Large-scale Multicenter Phase II Study Evaluating the Protective Effect of a Tissue Selective Estrogen Complex (TSEC) in Women With Newly Diagnosed Ductal Carcinoma in Situ Recruiting NCT02694809 Phase 2 Conjugated Estrogens/Bazedoxifene
44 Single Fraction Intraoperative Radiotherapy With Electrons: An Option in Breast-Conserving Operable Breast Cancer Stages 0, I and II - Prospective, Single-arm Trial Recruiting NCT01688388 Phase 1, Phase 2
45 Safety and Feasibility of Accelerated, Hypofractionated Radiotherapy in Women With Breast Cancer: A Phase II Trial Recruiting NCT00909909 Phase 2
46 TRI-fraction Radiotherapy Utilized to Minimize Patient Hospital Trips : A Phase II Trial (TRIUMPH-T Trial) Active, not recruiting NCT02526498 Phase 2
47 A Phase II Study of Accelerated 3 Fraction Photon and Proton Partial Breast External Beam Radiotherapy and Partial Breast Brachytherapy for Early Invasive and Noninvasive Breast Cancer Active, not recruiting NCT03391388 Phase 2
48 Impact of Breast Conservation Surgery on Surgical Outcomes and Cosmesis in Patients With Multiple Ipsilateral Breast Cancers (MIBC) Active, not recruiting NCT01556243 Phase 2
49 A Phase II Study of Repeat Breast Preserving Surgery and 3D-Conformal Partial Breast Re-Irradiation (PBrI) for Local Recurrence of Breast Carcinoma Active, not recruiting NCT01082211 Phase 2
50 VADIS Trial: Phase II Trial of Nelipeimut-S Peptide Vaccine in Women With DCIS of the Breast Active, not recruiting NCT02636582 Phase 2 Nelipepimut-S Plus GM-CSF Vaccine

Search NIH Clinical Center for Breast Carcinoma in Situ

Cochrane evidence based reviews: breast carcinoma in situ

Genetic Tests for Breast Carcinoma in Situ

Anatomical Context for Breast Carcinoma in Situ

The Foundational Model of Anatomy Ontology organs/tissues related to Breast Carcinoma in Situ:

19
Breast

MalaCards organs/tissues related to Breast Carcinoma in Situ:

40
Breast, Bone, Testes, Skin, Lymph Node, Lung, Thyroid

Publications for Breast Carcinoma in Situ

Articles related to Breast Carcinoma in Situ:

(show top 50) (show all 161)
# Title Authors PMID Year
1
Perineural and intraneural involvement in ductal carcinoma in-situ of breast: Case report. 61
31543222 2019
2
Ductal carcinoma in situ of breast: update 2019. 61
31472981 2019
3
Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ. 61
30816935 2019
4
MicroRNA Profiling of Salivary Duct Carcinoma Versus Her2/Neu Overexpressing Breast Carcinoma Identify miR-10a as a Putative Breast Related Oncogene. 61
30259272 2019
5
Pure secretory carcinoma in situ: a case report and literature review. 61
31443715 2019
6
"Development and validation of algorithms to differentiate ductal carcinoma in situ from invasive breast cancer within administrative claims data" by Hirth JM, Hatch SS, Lin Y, Giordano SH, Silva HC, Kuo Y. 61
30875106 2019
7
Sperm Protein Antigen 17 Expression Correlates With Lymph Node Metastasis and Worse Overall Survival in Patients With Breast Cancer. 61
31417875 2019
8
Clinical presentation of ductal carcinoma in situ of breast with intraluminal crystalloids: Radiologic-histologic correlation. 61
30241034 2018
9
Claudin-4 Expression Is Associated With Disease-Free Survival in Breast Carcinoma-in-Situ: Mean Follow-up of 8.2 Years. 61
30025999 2018
10
Sensitivity and specificity of breast cancer ICD-9-CM codes in three Italian administrative healthcare databases: a diagnostic accuracy study. 61
30037866 2018
11
Single-cell heterogeneity in ductal carcinoma in situ of breast. 61
29148540 2018
12
Androgen Receptors in Resected Ductal Carcinoma In Situ of Breast: Novel Insights With Possible Implications for Testing and Targeted Endocrine Chemoprevention Trials. 61
29489512 2018
13
Overtreatment in surgery - does it concern also the patients with ductal breast carcinoma in situ. 61
29513252 2018
14
Expression of periostin in breast cancer cells. 61
28902360 2017
15
Risk of death from breast cancer after treatment for ductal carcinoma in situ. 61
28832961 2017
16
Non-calcified ductal carcinoma in situ of the breast: comparison of diagnostic accuracy of digital breast tomosynthesis, digital mammography, and ultrasonography. 61
27837442 2017
17
Cytochrome c1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis. 61
28394473 2017
18
Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signaling. 61
28431393 2017
19
Mammographic extent of microcalcifications and oestrogen receptor expression affect preoperative breast carcinoma in situ size estimation. 61
27639877 2017
20
Plasma carotenoids and the risk of premalignant breast disease in women aged 50 and younger: a nested case-control study. 61
28190250 2017
21
Ductal carcinoma in situ of breast: detection and treatment pattern in Hong Kong. 61
27779099 2017
22
Paradigm Shift toward Reducing Overtreatment of Ductal Carcinoma In Situ of Breast. 61
28894698 2017
23
Reproductive factors and the risk of triple-negative breast cancer in white women and African-American women: a pooled analysis. 61
28086982 2017
24
Breast carcinoma in situ: An observational study of tumor subtype, treatment and outcomes. 61
27926499 2017
25
Differential distribution of immune cells in breast invasive carcinoma vs. breast carcinoma in situ and its significance in interpretation of immune surveillance. 61
31966621 2017
26
Ductal Breast Carcinoma In Situ: Mammographic Features and Its Relation to Prognosis and Tumour Biology in a Population Based Cohort. 61
28286675 2017
27
[Chinese expert consensus on the diagnosis and treatment of breast carcinoma in situ]. 61
27998472 2016
28
Loss of MLCK leads to disruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling. 61
26876209 2016
29
Tumor characteristics of ductal carcinoma in situ of breast visualized on [F-18] fluorodeoxyglucose-positron emission tomography/computed tomography: Results from a retrospective study. 61
27648168 2016
30
Different Biological Action of Oleic Acid in ALDHhigh and ALDHlow Subpopulations Separated from Ductal Carcinoma In Situ of Breast Cancer. 61
27589390 2016
31
Possible Prognostic Role of HER2/Neu in Ductal Carcinoma In Situ and Atypical Ductal Proliferative Lesions of the Breast. 61
27644608 2016
32
Cancer statistics: Breast cancer in situ. 61
26431342 2015
33
Octreotide LAR and tamoxifen versus tamoxifen in phase III randomize early breast cancer trials: NCIC CTG MA.14 and NSABP B-29. 61
26276354 2015
34
Basal cytokeratin phenotypes of myoepithelial cells indicates the origin of ductal carcinomas in situ of the breast. 61
26336082 2015
35
The prognostic role of HER2 expression in ductal breast carcinoma in situ (DCIS); a population-based cohort study. 61
26062614 2015
36
Context-Dependent Function of Myoepithelial Cells in Breast Morphogenesis and Neoplasia. 61
28680803 2015
37
Acoustic radiation force impulse elastography for differentiation of malignant and benign breast lesions: a meta-analysis. 61
26131049 2015
38
A prospective cohort study on postoperative radiotherapy with TomoDirect using simultaneous integrated boost technique in early breast cancer. 61
25410791 2014
39
Armc8 expression was elevated during atypia-to-carcinoma progression and associated with cancer development of breast carcinoma. 61
25119601 2014
40
Relative expression of hMena11a and hMenaINV splice isoforms is a useful biomarker in development and progression of human breast carcinoma. 61
25109497 2014
41
The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination. 61
25203208 2014
42
Determination of HER2/neu status: a pilot study comparing HER2/neu dual in situ hybridization DNA probe cocktail assay performed on cell blocks to immunohistochemisty and fluorescence in situ hybridization performed on histologic specimens. 61
24678687 2014
43
[The relationship between passive smoking, breast cancer risk and n-acetyltransferase 2 (NAT2)]. 61
24791559 2014
44
[Sentinel lymph node metastasis in patients with ductal breast carcinoma in situ]. 61
25312311 2014
45
High-resolution 3D micro-CT imaging of breast microcalcifications: a preliminary analysis. 61
24393444 2014
46
Diagnostic utility of E-cadherin and P120 catenin cocktail immunostain in distinguishing DCIS from LCIS. 61
24966968 2014
47
Elevated lipogenesis in epithelial stem-like cell confers survival advantage in ductal carcinoma in situ of breast cancer. 61
23208501 2013
48
Comparison of two breast carcinomas: ductal carcinoma in situ and lobular carcinoma in situ. 61
24147320 2013
49
[Expression Wnt2 in breast cancer tissues and sera of the patients]. 61
23746249 2013
50
Prospective study on physical activity and risk of in situ breast cancer. 61
23074288 2012

Variations for Breast Carcinoma in Situ

Expression for Breast Carcinoma in Situ

Search GEO for disease gene expression data for Breast Carcinoma in Situ.

Pathways for Breast Carcinoma in Situ

Pathways related to Breast Carcinoma in Situ according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.24 VEGFC VEGFA TP53 SDC1 MET KDR
2
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13.9 VEGFC TP53 MET KDR IL6ST IL6
3
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13.89 VEGFC VEGFA TP53 OSM MET KDR
4
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13.74 TP53 OSM MET KDR IL6ST IL6
5
Show member pathways
13.73 VEGFC VEGFA TP53 MET KDR IL6
6
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13.61 VEGFC MET KDR IL6 FLT4 FLT1
7
Show member pathways
13.61 VEGFC VEGFA TP53 MET KDR IL6
8
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13.49 VEGFC TP53 OSM MET KDR IL6
9
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13.44 VEGFA TP53 OSM MET IL6ST IL6
10
Show member pathways
13.41 VEGFC MET KDR IL6 FLT4 FLT1
11
Show member pathways
13.4 VEGFC OSM MET KDR IL6 FLT4
12
Show member pathways
13.37 VEGFC VEGFA MET KDR IL6 FLT4
13
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13.16 VEGFC TP53 MET KDR IL6 FLT4
14
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13.15 VEGFC MET KDR IL6 FLT4 FLT1
15
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13.01 MET KDR FLT4 FLT1 FGFR1 ERBB2
16
Show member pathways
12.99 VEGFC VEGFA MET KDR FLT4 FLT1
17
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12.87 TP53 MET FLT4 FGFR1 FGF2 ERBB2
18
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12.82 VEGFC VEGFA MET KDR FLT4 FLT1
19
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12.79 TP53 MET FGFR1 FGF2 ERBB2 BRCA2
20
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12.78 VEGFC MET KDR IL6 FLT4 FLT1
21
Show member pathways
12.77 TP53 MET FGFR1 FGF2 ERBB2
22
Show member pathways
12.75 VEGFA TP53 MET KDR IL6 FGF2
23 12.62 VEGFC VEGFA TP53 MET KDR FLT4
24 12.6 VEGFA TP53 MET ERBB2 BRCA1
25
Show member pathways
12.56 TP53 SDC1 MET KDR FLT4 FLT1
26
Show member pathways
12.55 TP53 MET KDR FLT4 FLT1 FGFR1
27
Show member pathways
12.48 VEGFC VEGFA KDR FLT4 FLT1
28
Show member pathways
12.47 VEGFC MET KDR IL6 FLT4 FLT1
29
Show member pathways
12.46 VEGFC VEGFA MET KDR FLT4 FLT1
30
Show member pathways
12.44 VEGFA SDC1 KDR BRCA1
31 12.42 VEGFC VEGFA TP53 MET IL6ST IL6
32
Show member pathways
12.39 TP53 SDC1 IL6 FGFR1 FGF2
33
Show member pathways
12.37 VEGFC VEGFA KDR FLT1 FGFR1 FGF2
34 12.32 VEGFA TP53 SDC1 MET KDR FGFR1
35 12.3 TP53 MET IL6 FLT1
36
Show member pathways
12.3 TP53 MET KDR IL6ST FLT4 FLT1
37
Show member pathways
12.3 VEGFC TP53 MET KDR IL6 FLT4
38
Show member pathways
12.28 VEGFA TP53 OSM IL6ST
39
Show member pathways
12.27 VEGFC VEGFA TP53 OSM MET KDR
40 12.21 VEGFA TP53 BRCA2 BRCA1
41 12.17 VEGFA MET KRT19 KDR IL6 FGF2
42 12.16 VEGFA TP53 SDC1 KDR
43 12.11 VEGFA TP53 OSM IL6 FGF2
44 12.03 VEGFA IL6 FLT1 ERBB2
45
Show member pathways
12.01 VEGFC VEGFA KDR FLT4 FLT1
46 11.96 VEGFC KDR FLT4 FLT1 FGFR1 FGF2
47 11.93 VEGFC MET KDR FLT4 FLT1 FGFR1
48
Show member pathways
11.91 KDR FLT4 FLT1 FGFR1
49
Show member pathways
11.85 TP53 BRCA2 BRCA1
50 11.82 VEGFA FGFR1 FGF2

GO Terms for Breast Carcinoma in Situ

Cellular components related to Breast Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.92 SDC1 MET KDR FLT4 FLT1 FGFR1
2 extracellular region GO:0005576 9.73 VEGFC VEGFA SDC1 OSM MET KDR
3 basal plasma membrane GO:0009925 9.43 MET ERBB2 CLDN4
4 receptor complex GO:0043235 9.17 MET KDR IL6ST FLT4 FLT1 FGFR1
5 interleukin-6 receptor complex GO:0005896 9.16 IL6ST IL6

Biological processes related to Breast Carcinoma in Situ according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.23 VEGFA TP53 OSM MET IL6 FGF2
2 multicellular organism development GO:0007275 10.23 VEGFC VEGFA TP53 OSM KDR FLT1
3 phosphorylation GO:0016310 10.16 MET KDR FLT4 FLT1 FGFR1 ERBB2
4 protein phosphorylation GO:0006468 10.15 MET KDR FLT4 FLT1 FGFR1 ERBB2
5 negative regulation of apoptotic process GO:0043066 10.13 VEGFA TP53 KDR IL6ST IL6 FLT4
6 positive regulation of gene expression GO:0010628 10.1 VEGFA TP53 IL6 ERBB2 BRCA1
7 cytokine-mediated signaling pathway GO:0019221 10.04 VEGFA TP53 SDC1 OSM IL6ST IL6
8 positive regulation of protein phosphorylation GO:0001934 10.02 VEGFC VEGFA KDR FLT4 ERBB2
9 MAPK cascade GO:0000165 10.01 MET FGFR1 FGF2 ERBB2
10 positive regulation of cell migration GO:0030335 10.01 VEGFA KDR FLT1 CLDN4
11 cell migration GO:0016477 10.01 SDC1 KDR FLT1 FGFR1
12 positive regulation of protein kinase B signaling GO:0051897 10.01 OSM MET FGFR1 FGF2 ERBB2
13 protein autophosphorylation GO:0046777 10 KDR FLT4 FLT1 FGFR1 ERBB2
14 positive regulation of angiogenesis GO:0045766 9.99 VEGFC VEGFA KDR FLT1 FGF2 BRCA1
15 angiogenesis GO:0001525 9.95 VEGFC VEGFA KDR FLT4 FLT1 FGFR1
16 wound healing GO:0042060 9.94 TP53 SDC1 FGF2 ERBB2
17 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.94 VEGFA TP53 OSM IL6
18 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.93 OSM KDR FLT1 FGFR1
19 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.92 VEGFA OSM IL6ST IL6
20 positive regulation of endothelial cell proliferation GO:0001938 9.92 VEGFC VEGFA KDR FLT4 FGF2
21 peptidyl-tyrosine phosphorylation GO:0018108 9.91 MET KDR FLT4 FLT1 FGFR1 ERBB2
22 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.89 VEGFA OSM IL6
23 positive chemotaxis GO:0050918 9.88 VEGFC VEGFA MET FGF2
24 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.88 VEGFC VEGFA KDR FLT4 FLT1
25 double-strand break repair GO:0006302 9.87 TP53 BRCA2 BRCA1
26 positive regulation of epithelial cell proliferation GO:0050679 9.87 VEGFC VEGFA ERBB2
27 positive regulation of cell division GO:0051781 9.87 VEGFC VEGFA OSM FGF2
28 positive regulation of endothelial cell migration GO:0010595 9.86 VEGFA KDR FLT4
29 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.86 VEGFA KDR FLT4 FLT1
30 positive regulation of vascular endothelial growth factor production GO:0010575 9.85 IL6ST IL6 FLT4 BRCA1
31 positive regulation of MAP kinase activity GO:0043406 9.85 VEGFA FLT1 FGFR1 FGF2 ERBB2
32 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.83 VEGFA KDR FGF2
33 regulation of angiogenesis GO:0045765 9.83 IL6 FGF2 ERBB2
34 blood vessel morphogenesis GO:0048514 9.82 FLT4 FLT1 FGFR1
35 cell migration involved in sprouting angiogenesis GO:0002042 9.8 VEGFA KDR FGF2
36 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.8 MET KDR FLT4 FLT1 FGFR1 ERBB2
37 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.77 TP53 BRCA2 BRCA1
38 positive regulation of acute inflammatory response GO:0002675 9.77 OSM IL6ST IL6
39 positive regulation of blood vessel endothelial cell migration GO:0043536 9.77 VEGFC VEGFA KDR FGFR1 FGF2
40 positive regulation of phospholipase C activity GO:0010863 9.76 FLT1 FGFR1 FGF2
41 positive regulation of positive chemotaxis GO:0050927 9.71 VEGFA KDR
42 chordate embryonic development GO:0043009 9.71 FGFR1 BRCA2 BRCA1
43 positive regulation of endothelial cell chemotaxis GO:2001028 9.7 MET FGF2
44 positive regulation of protein kinase C signaling GO:0090037 9.7 VEGFA FLT4
45 positive regulation of MAPK cascade GO:0043410 9.7 OSM KDR IL6 FLT4 FLT1 FGFR1
46 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.68 VEGFA TP53
47 positive regulation of mast cell chemotaxis GO:0060754 9.68 VEGFC VEGFA
48 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.67 VEGFA KDR
49 positive regulation of endothelial cell chemotaxis to fibroblast growth factor GO:2000546 9.67 FGFR1 FGF2
50 oncostatin-M-mediated signaling pathway GO:0038165 9.66 OSM IL6ST

Molecular functions related to Breast Carcinoma in Situ according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.46 VEGFC VEGFA TP53 SDC1 OSM MET
2 kinase activity GO:0016301 10.01 MET KDR FLT4 FLT1 FGFR1 ERBB2
3 protein kinase activity GO:0004672 9.93 MET KDR FLT4 FLT1 FGFR1 ERBB2
4 cytokine activity GO:0005125 9.87 VEGFA OSM IL6 FGF2
5 protein C-terminus binding GO:0008022 9.86 TP53 SDC1 ERBB2 BRCA2
6 growth factor activity GO:0008083 9.8 VEGFC VEGFA OSM IL6 FGF2
7 protein phosphatase binding GO:0019903 9.73 TP53 MET FLT4 ERBB2
8 protein tyrosine kinase activity GO:0004713 9.73 MET KDR FLT4 FLT1 FGFR1 ERBB2
9 identical protein binding GO:0042802 9.7 VEGFA TP53 SDC1 MET KDR IL6ST
10 chemoattractant activity GO:0042056 9.65 VEGFC VEGFA FGF2
11 interleukin-6 receptor binding GO:0005138 9.55 IL6ST IL6
12 growth factor binding GO:0019838 9.55 KDR IL6ST FLT4 FLT1 ERBB2
13 vascular endothelial growth factor binding GO:0038085 9.54 KDR FLT4 FLT1
14 vascular endothelial growth factor receptor binding GO:0005172 9.52 VEGFC VEGFA
15 vascular endothelial growth factor-activated receptor activity GO:0005021 9.5 KDR FLT4 FLT1
16 receptor-receptor interaction GO:0090722 9.49 FGFR1 FGF2
17 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.1 MET KDR FLT4 FLT1 FGFR1 ERBB2

Sources for Breast Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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