Aliases & Classifications for Breast Cyst

MalaCards integrated aliases for Breast Cyst:

Name: Breast Cyst 12 44 15 17
Cyst of the Breast 12
Breast Cysts 54

Classifications:



External Ids:

Disease Ontology 12 DOID:10350
MeSH 44 D047688
NCIt 50 C5315
SNOMED-CT 67 56726003
ICD10 32 N60.0
UMLS 70 C0006144

Summaries for Breast Cyst

Disease Ontology : 12 A breast benign neoplasm that is characterized by a fluid-filled sac.

MalaCards based summary : Breast Cyst, also known as cyst of the breast, is related to syringocystadenoma papilliferum and breast fibroadenoma. An important gene associated with Breast Cyst is PIP (Prolactin Induced Protein), and among its related pathways/superpathways are Pathways in cancer and Endometrial cancer. The drug Silicon has been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and thyroid, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Wikipedia : 73 A breast cyst is a fluid-filled sac within the breast. One breast can have one or more breast cysts.... more...

Related Diseases for Breast Cyst

Diseases related to Breast Cyst via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 syringocystadenoma papilliferum 30.0 SERPINA3 PIP
2 breast fibroadenoma 29.8 SERPINA3 CYP19A1 CTSD
3 in situ carcinoma 29.2 SERPINA3 PIP EGF CYP19A1
4 ductal carcinoma in situ 29.0 PIP EGF CYP19A1 CTSD
5 gynecomastia 29.0 PRL KLK3 CYP19A1
6 breast disease 28.4 TGFB1 SERPINA3 PRL KLK3 EGF CYP19A1
7 breast cancer 26.7 TGFB2 TGFB1 SERPINA3 PRL PIP KLK3
8 solitary cyst of breast 11.0
9 lactocele 11.0
10 benign mammary dysplasia 11.0
11 xanthogranulomatous pyelonephritis 10.3 SERPINA3 EGF
12 breast secretory carcinoma 10.3 SERPINA3 PIP
13 apocrine adenocarcinoma 10.2 SERPINA3 PIP
14 chronic asthma 10.2 EGF BMP6
15 sebaceous adenoma 10.2 SERPINA3 EGF
16 papillary cystadenocarcinoma 10.2 SERPINA3 PIP
17 polycystic liver disease 1 with or without kidney cysts 10.2
18 keloid disorder 10.2 TGFB1 BMP6
19 eccrine papillary adenocarcinoma 10.2 PIP KLK3
20 epidermoid cysts 10.2
21 cholecystolithiasis 10.2 TGFB1 BMP6
22 high-grade astrocytoma 10.2 TGFB2 KLK6
23 otomycosis 10.2 AZGP1 APOD
24 urethral stricture 10.2 TGFB1 KLK3
25 prostatic hyperplasia, benign 10.1 SERPINA3 KLK3
26 hypertrophic scars 10.1 TGFB1 BMP6
27 trachoma 10.1 TGFB1 SERPINA3 EGF
28 eosinophilia-myalgia syndrome 10.1 TGFB1 BMP6
29 sweat gland benign neoplasm 10.1 SERPINA3 PIP
30 mixed cell adenoma 10.1 EGF CTSD
31 steroid-induced glaucoma 10.1 TGFB2 SERPINA3
32 male reproductive organ benign neoplasm 10.1 SERPINA3 KLK3
33 gingival overgrowth 10.1 TGFB2 TGFB1 EGF
34 urinary tract obstruction 10.1 TGFB1 KLK3 EGF
35 communicating hydrocephalus 10.0 TGFB1 SERPINA3
36 alport syndrome 10.0 TGFB1 EGF BMP6
37 benign teratoma 10.0
38 echinococcosis 10.0
39 benign breast phyllodes tumor 10.0
40 cystic teratoma 10.0
41 mature teratoma 10.0
42 phacogenic glaucoma 10.0 TGFB2 SERPINA3
43 tuberculoid leprosy 10.0 TGFB2 TGFB1 BMP6
44 suppression of tumorigenicity 12 10.0 SERPINA3 KLK3 EGF
45 bladder sarcoma 10.0 SERPINA3 KLK3
46 stiff skin syndrome 10.0 TGFB2 TGFB1
47 hereditary hemorrhagic telangiectasia 10.0 TGFB2 TGFB1 BMP6
48 insulin-like growth factor i 10.0
49 microglandular adenosis 10.0
50 peyronie's disease 9.9 TGFB2 TGFB1

Graphical network of the top 20 diseases related to Breast Cyst:



Diseases related to Breast Cyst

Symptoms & Phenotypes for Breast Cyst

MGI Mouse Phenotypes related to Breast Cyst:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.73 CTSD CYP19A1 EGF PIP TGFB1 TGFB2
2 endocrine/exocrine gland MP:0005379 9.7 CTSD CYP19A1 EGF PIP PRL TGFB1
3 immune system MP:0005387 9.61 AZGP1 CTSD CYP19A1 EGF KLK6 PIP
4 integument MP:0010771 9.17 CTSD CYP19A1 EGF KLK6 PRL SERPINA3

Drugs & Therapeutics for Breast Cyst

Drugs for Breast Cyst (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Silicon Approved, Investigational 7440-21-3 4082203

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Early Screening of Breast Cancer Using Radiation-Free Pressure-Free Optical Scanning Unknown status NCT00671385
2 Simulated Screening Study of Combined Digital X-Ray, Ultrasound and Photoacoustic Breast Imaging Completed NCT01807754
3 Comparison of M5 and M6 Versions of the MARIA Imaging System on Patients Attending Symptomatic Breast Clinic in Cheltenham, United Kingdom (UK), Including a Sub-study to Research the Dielectric Constant of Aspirated Cyst Fluid Completed NCT03771833
4 Pilot Clinical Evaluation of a Microwave Imaging System for Early Breast Cancer Detection Completed NCT03475992
5 2D Silicon Transducer-Compression Plates for Breast Ultrasound Completed NCT00859261

Search NIH Clinical Center for Breast Cyst

Cochrane evidence based reviews: breast cyst

Genetic Tests for Breast Cyst

Anatomical Context for Breast Cyst

MalaCards organs/tissues related to Breast Cyst:

40
Breast, Prostate, Thyroid, Skin, Kidney, Liver

Publications for Breast Cyst

Articles related to Breast Cyst:

(show top 50) (show all 408)
# Title Authors PMID Year
1
Breast cyst fluid plasmin activity and its effect on TGF-beta2 activation. 54 61
18181041 2008
2
Prostatic acid phosphatase in breast cyst fluid. 54 61
19108401 2007
3
Cytological and biochemical studies of breast cyst fluid. 61 54
15695079 2005
4
Enterolactone in breast cyst fluid: correlation with EGF and breast cancer risk. 61 54
12779078 2003
5
[Relationship between estrogen, progesterone, total testosterone, androstenedione, and epidural growth factor in blood and breast cyst fluid]. 61 54
12185717 2002
6
Differential distribution of soluble and complexed forms of prostate-specific antigen in cyst fluids of women with gross cystic breast disease. 61 54
11291110 2001
7
Prostate specific antigen in the female body: its role in breast cancer prognosis. 61 54
11128396 2000
8
Prostate-specific antigen found in type I breast cyst fluids is a secretory product of the apocrine cells lining breast gross cysts. 61 54
10598042 1999
9
Latent forms of transforming growth factor-beta 2 (TGF-beta 2) in breast cyst fluid. 54 61
10652596 1999
10
Prostate specific antigen molecular forms in breast cyst fluid and serum of women with fibrocystic breast disease. 54 61
10102136 1999
11
[Levels of Cathepsin D in breast cyst fluid]. 61 54
9296601 1997
12
Regulation of aromatase activity within the breast. 61 54
9365190 1997
13
Biochemical characterization and crystalization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog. 54 61
9114041 1997
14
Quantification of apolipoprotein D by an immunoassay with time-resolved fluorescence spectroscopy. 61 54
9075775 1997
15
Prostate-specific antigen in breast cyst fluid: possible role of prostate-specific antigen in hormone-dependent breast cancer. 61 54
8647643 1996
16
Prostate specific antigen--a new constituent of breast cyst fluid. 61 54
8739078 1996
17
Quantification of prostate-specific antigen immunoreactivity in human breast cyst fluids. 54 61
8739076 1996
18
Epidermal growth factor content of breast cyst fluids from women with breast cancer or proliferative disease of the breast. 54 61
7749149 1995
19
Relationship between basic fibroblast growth factor and transforming growth factor-beta 2 in breast cyst fluid. 61 54
7852541 1995
20
Presence of immunoassayable transforming growth factor-beta 1 (TGF-beta 1) in breast cyst fluid (BCF): relationship with the intracystic electrolyte and epidermal-growth-factor (EGF) content. 54 61
7989108 1994
21
Stimulation of aromatase activity in breast fibroblasts by tumor necrosis factor alpha. 54 61
7895904 1994
22
Relationships of Na+ and K+ concentrations to GRP, CGRP, and calcitonin immunoreactivities and Na+,K(+)-ATPase (NKA) inhibitory activity in human breast cyst fluid. 54 61
7850533 1994
23
Growth factor profiles in breast cyst fluid identify women with increased breast cancer risk. 54 61
8185042 1994
24
Alpha 1-antichymotrypsin complexes in human breast cyst fluids. 54 61
8149344 1994
25
Identification of multiple proliferative growth factors in breast cyst fluid. 61 54
8368433 1993
26
Interleukin-1 and interleukin-6 in breast cyst fluid: their role in regulating aromatase activity in breast cancer cells. 54 61
1564416 1992
27
Quantification and molecular analysis of cathepsin D in breast cyst fluids. 61 54
1524902 1992
28
Cathepsin D and epidermal growth factor in human breast cyst fluid. 54 61
1931627 1991
29
[Epidermal growth factor behavior in breast cyst fluid. Differences as a function of the three existing types]. 61 54
1745812 1991
30
EGF in breast cyst fluid: relationships with intracystic androgens, estradiol and progesterone. 61 54
1995483 1991
31
Identification of breast cyst subpopulations: biochemical and morphological features. 54 61
1838953 1991
32
Unbound, biologically active oestradiol, sex hormone-binding globulin, epidermal growth factor and electrolytes in breast cyst fluid. 61 54
2009188 1991
33
Zinc alpha-2 glycoprotein levels in serum and breast fluids: a potential marker of apocrine activity. 61 54
1828959 1991
34
Mitogenic peptides in breast cyst fluid: relationship with intracystic electrolyte ratios. 54 61
2249889 1990
35
Levels of human chorionic gonadotropin in breast cyst fluid. 54 61
2286777 1990
36
Identification of a unique biological tumor marker in human breast cyst fluid and breast cancer tissue. 61 54
2334010 1990
37
Epidermal growth factor and oestradiol in human breast cyst fluid. 54 61
2141515 1990
38
Epidermal growth factor in breast cyst fluids. Relationships with the morphology of cyst epithelium. 61 54
2141456 1990
39
Epidermal growth factor and insulinlike growth factor-I in human breast cyst fluid. 61 54
2356997 1990
40
Epidermal growth factor and prolactin in human breast cyst fluid. Possible correlations with GCDFP-15. 54 61
2356996 1990
41
Benign cyst of the male breast. An exceedingly rare entity that may pose a diagnostic dilemma. Management and literature review. 61
33749635 2021
42
Comment on: Hydatid cyst of the breast: Case report. 61
33418423 2021
43
Breast Trauma and Triple-Negative Hemorrhagic Cystic Carcinoma: Management and Treatment. 61
33311426 2020
44
Visualization of the shear wave on gray-scale ultrasound: experience with a complex breast cyst. 61
32190862 2020
45
Bloody Nipple Discharge Post Delivery: A Case of "Rusty Pipe Syndrome". 61
32475105 2020
46
Abnormal Galactosylated-Glycans recognized by Bandeiraea Simplicifolia Lectin I in saliva of patients with breast Cancer. 61
32103424 2020
47
SVM-Enabled Intelligent Genetic Algorithmic Model for Realizing Efficient Universal Feature Selection in Breast Cyst Image Acquired via Ultrasound Sensing Systems. 61
31940932 2020
48
Hydatid disease - An unusual cause of a breast cyst: Case report. 61
32182579 2020
49
Hydatid cyst of the breast: case report. 61
33197778 2020
50
[Analysis of common gynecological diseases in 1142 married female workers]. 61
31726513 2019

Variations for Breast Cyst

Expression for Breast Cyst

Search GEO for disease gene expression data for Breast Cyst.

Pathways for Breast Cyst

Pathways related to Breast Cyst according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1 12.62 TGFB2 TGFB1 KLK3 EGF
2
Show member pathways
12.54 TGFB2 TGFB1 KLK3 EGF
3
Show member pathways
12.4 TGFB2 TGFB1 EGF BMP6
4
Show member pathways
12.13 TGFB2 TGFB1 EGF BMP6
5 12.01 TGFB2 TGFB1 BMP6
6 12 TGFB2 TGFB1 CTSD
7 11.92 TGFB2 TGFB1 EGF
8 11.88 TGFB2 TGFB1 BMP6
9
Show member pathways
11.77 TGFB2 TGFB1 EGF
10 11.47 TGFB2 TGFB1 BMP6
11 11.41 TGFB2 TGFB1 BMP6
12 11.31 TGFB2 TGFB1 EGF BMP6
13
Show member pathways
11.27 TGFB2 TGFB1 EGF
14 11.06 TGFB2 TGFB1
15 10.94 TGFB2 TGFB1 BMP6
16 10.9 TGFB2 TGFB1 EGF BMP6
17 10.77 PIP AZGP1
18 10.66 TGFB2 TGFB1
19 10.46 TGFB2 TGFB1 PIP EGF BMP6
20 10.45 TGFB2 TGFB1

GO Terms for Breast Cyst

Cellular components related to Breast Cyst according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 SERPINA3 PIP KLK3 EGF CTSD AZGP1
2 extracellular region GO:0005576 9.73 TGFB2 TGFB1 SERPINA3 PRL PIP KLK6
3 collagen-containing extracellular matrix GO:0062023 9.65 TGFB2 TGFB1 SERPINA3 CTSD AZGP1
4 secretory granule GO:0030141 9.5 TGFB1 KLK6 KLK3
5 platelet alpha granule lumen GO:0031093 9.46 TGFB2 TGFB1 SERPINA3 EGF
6 extracellular space GO:0005615 9.4 TGFB2 TGFB1 SERPINA3 PRL PIP KLK6

Biological processes related to Breast Cyst according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.88 TGFB1 PIP EGF BMP6
2 positive regulation of cell proliferation GO:0008284 9.83 TGFB2 TGFB1 PRL EGF BMP6
3 negative regulation of angiogenesis GO:0016525 9.73 TGFB2 PRL KLK3
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.69 TGFB1 EGF BMP6
5 BMP signaling pathway GO:0030509 9.67 TGFB2 TGFB1 BMP6
6 response to wounding GO:0009611 9.63 TGFB2 TGFB1 KLK6
7 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.59 TGFB1 EGF
8 cell-cell junction organization GO:0045216 9.58 TGFB2 TGFB1
9 tissue regeneration GO:0042246 9.57 KLK6 APOD
10 positive regulation of SMAD protein signal transduction GO:0060391 9.55 TGFB1 BMP6
11 pathway-restricted SMAD protein phosphorylation GO:0060389 9.54 TGFB2 TGFB1
12 SMAD protein signal transduction GO:0060395 9.54 TGFB2 TGFB1 BMP6
13 positive regulation of vascular permeability GO:0043117 9.52 TGFB1 BMP6
14 salivary gland morphogenesis GO:0007435 9.48 TGFB2 TGFB1
15 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.43 TGFB2 TGFB1 BMP6
16 heart valve morphogenesis GO:0003179 9.4 TGFB2 TGFB1
17 positive regulation of protein secretion GO:0050714 9.33 TGFB2 TGFB1 BMP6
18 negative regulation of macrophage cytokine production GO:0010936 9.32 TGFB2 TGFB1
19 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.13 TGFB2 TGFB1 PRL
20 platelet degranulation GO:0002576 8.92 TGFB2 TGFB1 SERPINA3 EGF

Molecular functions related to Breast Cyst according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aspartic-type endopeptidase activity GO:0004190 9.32 PIP CTSD
2 transforming growth factor beta receptor binding GO:0005160 9.26 TGFB2 TGFB1
3 type II transforming growth factor beta receptor binding GO:0005114 9.16 TGFB2 TGFB1
4 type III transforming growth factor beta receptor binding GO:0034714 8.96 TGFB2 TGFB1
5 growth factor activity GO:0008083 8.92 TGFB2 TGFB1 EGF BMP6

Sources for Breast Cyst

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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