MCID: BRS037
MIFTS: 20

Breast Cystic Hypersecretory Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Breast Cystic Hypersecretory Carcinoma

MalaCards integrated aliases for Breast Cystic Hypersecretory Carcinoma:

Name: Breast Cystic Hypersecretory Carcinoma 12 15
Cystic Hypersecretory Duct Carcinoma of the Breast 12
Cystic Hypersecretory Carcinoma of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7537

Summaries for Breast Cystic Hypersecretory Carcinoma

Disease Ontology : 12 A breast secretory carcinoma that is characterized by numerous cysts of varying sizes containing gelatinous material on gross examination, microscopically dilated ducts containing eosinophilic secretion and the absence of micropapillary pattern and cytological atypia in the lining epithelium.

MalaCards based summary : Breast Cystic Hypersecretory Carcinoma, also known as cystic hypersecretory duct carcinoma of the breast, is related to breast cancer and sulfite oxidase deficiency due to molybdenum cofactor deficiency. An important gene associated with Breast Cystic Hypersecretory Carcinoma is KRT5 (Keratin 5), and among its related pathways/superpathways are Bladder cancer and Adherens junction. Affiliated tissues include breast, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Breast Cystic Hypersecretory Carcinoma

Diseases related to Breast Cystic Hypersecretory Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 breast cancer 10.1
2 sulfite oxidase deficiency due to molybdenum cofactor deficiency 10.1
3 lymphoepithelioma-like thymic carcinoma 10.1 KRT5 TG
4 cystadenofibroma 10.1 KRT5 TG
5 acute thyroiditis 10.1 LALBA TG
6 esophageal adenosquamous carcinoma 10.1 CDH1 KRT5
7 breast adenomyoepithelioma 10.1 CDH1 KRT5
8 breast myoepithelial neoplasm 10.1 CDH1 KRT5
9 lymphoepithelioma-like carcinoma 10.1 CDH1 KRT5
10 oropharynx cancer 10.0 CDH1 KRT5
11 spindle cell carcinoma 10.0 CDH1 KRT5
12 celiac disease 1 10.0 LALBA TG
13 anaplastic thyroid cancer 10.0 CDH1 TG
14 breast metaplastic carcinoma 10.0 ERBB2 KRT5
15 apocrine adenocarcinoma 10.0 ERBB2 KRT5
16 breast squamous cell carcinoma 10.0 ERBB2 KRT5
17 breast benign neoplasm 9.9 ERBB2 KRT5
18 thoracic benign neoplasm 9.9 ERBB2 KRT5
19 hidradenocarcinoma 9.9 ERBB2 KRT5
20 breast carcinoma in situ 9.9 ERBB2 KRT5
21 sweat gland cancer 9.9 ERBB2 KRT5
22 immune system disease 9.9 CDH1 TG
23 inflammatory breast carcinoma 9.9 CDH1 ERBB2
24 lobular neoplasia 9.9 CDH1 ERBB2
25 tubular adenocarcinoma 9.8 CDH1 ERBB2
26 mucoepidermoid carcinoma 9.8 ERBB2 TG
27 papillary adenocarcinoma 9.8 CDH1 ERBB2
28 ovarian cancer 1 9.8 CDH1 ERBB2
29 malignant ovarian surface epithelial-stromal neoplasm 9.8 CDH1 ERBB2
30 ovary epithelial cancer 9.8 CDH1 ERBB2
31 uterine anomalies 9.8 CDH1 ERBB2
32 bladder disease 9.8 CDH1 ERBB2
33 stomach disease 9.8 CDH1 ERBB2
34 female reproductive system disease 9.8 CDH1 ERBB2
35 reproductive system disease 9.8 CDH1 ERBB2
36 respiratory system cancer 9.8 CDH1 ERBB2
37 uterine carcinosarcoma 9.8 CDH1 ERBB2
38 breast ductal carcinoma 9.8 CDH1 ERBB2
39 oral cavity cancer 9.7 CDH1 ERBB2
40 gastrointestinal system cancer 9.7 CDH1 ERBB2
41 transitional cell carcinoma 9.7 CDH1 ERBB2
42 gastrointestinal system disease 9.7 CDH1 ERBB2
43 pancreas adenocarcinoma 9.7 CDH1 ERBB2
44 breast disease 9.7 ERBB2 KRT5
45 tonsil cancer 9.6 CDH1 ERBB2 KRT5
46 gallbladder cancer 9.6 CDH1 ERBB2
47 pre-malignant neoplasm 9.6 CDH1 ERBB2 KRT5
48 in situ carcinoma 9.6 CDH1 ERBB2 KRT5
49 ductal carcinoma in situ 9.6 CDH1 ERBB2 KRT5
50 adenoid cystic carcinoma 9.6 CDH1 ERBB2 KRT5

Graphical network of the top 20 diseases related to Breast Cystic Hypersecretory Carcinoma:



Diseases related to Breast Cystic Hypersecretory Carcinoma

Symptoms & Phenotypes for Breast Cystic Hypersecretory Carcinoma

MGI Mouse Phenotypes related to Breast Cystic Hypersecretory Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.46 CDH1 ERBB2 KRT5 TG
2 endocrine/exocrine gland MP:0005379 9.26 CDH1 ERBB2 LALBA TG
3 integument MP:0010771 8.92 CDH1 ERBB2 KRT5 LALBA

Drugs & Therapeutics for Breast Cystic Hypersecretory Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Cystic Hypersecretory Carcinoma

Genetic Tests for Breast Cystic Hypersecretory Carcinoma

Anatomical Context for Breast Cystic Hypersecretory Carcinoma

MalaCards organs/tissues related to Breast Cystic Hypersecretory Carcinoma:

42
Breast

Publications for Breast Cystic Hypersecretory Carcinoma

Articles related to Breast Cystic Hypersecretory Carcinoma:

# Title Authors Year
1
Invasive cystic hypersecretory carcinoma of the breast: a rare variant of breast cancer: a case report and review of the literature. ( 30621638 )
2019

Variations for Breast Cystic Hypersecretory Carcinoma

Cosmic variations for Breast Cystic Hypersecretory Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM520 KRAS breast,NS,carcinoma,micropapillary c.35G>T p.G12V 12:25245350-25245350 0

Expression for Breast Cystic Hypersecretory Carcinoma

Search GEO for disease gene expression data for Breast Cystic Hypersecretory Carcinoma.

Pathways for Breast Cystic Hypersecretory Carcinoma

Pathways related to Breast Cystic Hypersecretory Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.02 CDH1 ERBB2
2 10.81 CDH1 ERBB2
3 10.11 CDH1 ERBB2

GO Terms for Breast Cystic Hypersecretory Carcinoma

Sources for Breast Cystic Hypersecretory Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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