MCID: BRS037
MIFTS: 21

Breast Cystic Hypersecretory Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Breast Cystic Hypersecretory Carcinoma

MalaCards integrated aliases for Breast Cystic Hypersecretory Carcinoma:

Name: Breast Cystic Hypersecretory Carcinoma 12 15
Cystic Hypersecretory Duct Carcinoma of the Breast 12
Cystic Hypersecretory Carcinoma of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7537

Summaries for Breast Cystic Hypersecretory Carcinoma

Disease Ontology : 12 A breast secretory carcinoma that is characterized by numerous cysts of varying sizes containing gelatinous material on gross examination, microscopically dilated ducts containing eosinophilic secretion and the absence of micropapillary pattern and cytological atypia in the lining epithelium.

MalaCards based summary : Breast Cystic Hypersecretory Carcinoma, also known as cystic hypersecretory duct carcinoma of the breast, is related to lymphoepithelioma-like thymic carcinoma and cystadenofibroma. An important gene associated with Breast Cystic Hypersecretory Carcinoma is KRT5 (Keratin 5), and among its related pathways/superpathways are Bladder cancer and Adherens junction. Affiliated tissues include ovary, tonsil and pancreas, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Breast Cystic Hypersecretory Carcinoma

Diseases related to Breast Cystic Hypersecretory Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 lymphoepithelioma-like thymic carcinoma 10.1 KRT5 TG
2 cystadenofibroma 10.1 KRT5 TG
3 acute thyroiditis 10.1 LALBA TG
4 esophageal adenosquamous carcinoma 10.1 CDH1 KRT5
5 breast adenomyoepithelioma 10.0 CDH1 KRT5
6 breast myoepithelial neoplasm 10.0 CDH1 KRT5
7 lymphoepithelioma-like carcinoma 10.0 CDH1 KRT5
8 oropharynx cancer 10.0 CDH1 KRT5
9 spindle cell carcinoma 10.0 CDH1 KRT5
10 anaplastic thyroid cancer 10.0 CDH1 TG
11 breast metaplastic carcinoma 10.0 ERBB2 KRT5
12 apocrine adenocarcinoma 10.0 ERBB2 KRT5
13 breast squamous cell carcinoma 10.0 ERBB2 KRT5
14 breast benign neoplasm 10.0 ERBB2 KRT5
15 thoracic benign neoplasm 10.0 ERBB2 KRT5
16 hidradenocarcinoma 10.0 ERBB2 KRT5
17 breast carcinoma in situ 10.0 ERBB2 KRT5
18 sweat gland cancer 9.9 ERBB2 KRT5
19 celiac disease 1 9.9 LALBA TG
20 inflammatory breast carcinoma 9.9 CDH1 ERBB2
21 lobular neoplasia 9.9 CDH1 ERBB2
22 tubular adenocarcinoma 9.9 CDH1 ERBB2
23 papillary adenocarcinoma 9.9 CDH1 ERBB2
24 mucoepidermoid carcinoma 9.9 ERBB2 TG
25 ovarian cancer 1 9.9 CDH1 ERBB2
26 malignant ovarian surface epithelial-stromal neoplasm 9.9 CDH1 ERBB2
27 ovary epithelial cancer 9.9 CDH1 ERBB2
28 uterine anomalies 9.9 CDH1 ERBB2
29 bladder disease 9.9 CDH1 ERBB2
30 stomach disease 9.9 CDH1 ERBB2
31 female reproductive system disease 9.9 CDH1 ERBB2
32 reproductive system disease 9.9 CDH1 ERBB2
33 respiratory system cancer 9.9 CDH1 ERBB2
34 uterine carcinosarcoma 9.8 CDH1 ERBB2
35 breast ductal carcinoma 9.8 CDH1 ERBB2
36 oral cavity cancer 9.8 CDH1 ERBB2
37 gastrointestinal system cancer 9.8 CDH1 ERBB2
38 transitional cell carcinoma 9.8 CDH1 ERBB2
39 gastrointestinal system disease 9.8 CDH1 ERBB2
40 pancreas adenocarcinoma 9.8 CDH1 ERBB2
41 breast disease 9.8 ERBB2 KRT5
42 gallbladder cancer 9.8 CDH1 ERBB2
43 tonsil cancer 9.8 CDH1 ERBB2 KRT5
44 pre-malignant neoplasm 9.8 CDH1 ERBB2 KRT5
45 in situ carcinoma 9.8 CDH1 ERBB2 KRT5
46 ductal carcinoma in situ 9.8 CDH1 ERBB2 KRT5
47 adenoid cystic carcinoma 9.7 CDH1 ERBB2 KRT5
48 papillary carcinoma 9.7 CDH1 ERBB2 TG
49 endocrine gland cancer 9.7 CDH1 ERBB2 TG
50 cervical cancer 9.7 CDH1 ERBB2 KRT5

Graphical network of the top 20 diseases related to Breast Cystic Hypersecretory Carcinoma:



Diseases related to Breast Cystic Hypersecretory Carcinoma

Symptoms & Phenotypes for Breast Cystic Hypersecretory Carcinoma

MGI Mouse Phenotypes related to Breast Cystic Hypersecretory Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.46 CDH1 ERBB2 KRT5 TG
2 endocrine/exocrine gland MP:0005379 9.26 CDH1 ERBB2 LALBA TG
3 integument MP:0010771 8.92 CDH1 ERBB2 KRT5 LALBA

Drugs & Therapeutics for Breast Cystic Hypersecretory Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Cystic Hypersecretory Carcinoma

Genetic Tests for Breast Cystic Hypersecretory Carcinoma

Anatomical Context for Breast Cystic Hypersecretory Carcinoma

MalaCards organs/tissues related to Breast Cystic Hypersecretory Carcinoma:

41
Ovary, Tonsil, Pancreas, Thyroid

Publications for Breast Cystic Hypersecretory Carcinoma

Variations for Breast Cystic Hypersecretory Carcinoma

Cosmic variations for Breast Cystic Hypersecretory Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM520 KRAS breast,NS,carcinoma,micropapillary c.35G>T p.G12V 12:25245350-25245350 11

Expression for Breast Cystic Hypersecretory Carcinoma

Search GEO for disease gene expression data for Breast Cystic Hypersecretory Carcinoma.

Pathways for Breast Cystic Hypersecretory Carcinoma

Pathways related to Breast Cystic Hypersecretory Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.02 CDH1 ERBB2
2 10.81 CDH1 ERBB2
3 10.11 CDH1 ERBB2

GO Terms for Breast Cystic Hypersecretory Carcinoma

Sources for Breast Cystic Hypersecretory Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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