MCID: BRS037
MIFTS: 23

Breast Cystic Hypersecretory Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Breast Cystic Hypersecretory Carcinoma

MalaCards integrated aliases for Breast Cystic Hypersecretory Carcinoma:

Name: Breast Cystic Hypersecretory Carcinoma 12 15
Cystic Hypersecretory Duct Carcinoma of the Breast 12
Cystic Hypersecretory Carcinoma of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7537

Summaries for Breast Cystic Hypersecretory Carcinoma

Disease Ontology : 12 A breast secretory carcinoma that is characterized by numerous cysts of varying sizes containing gelatinous material on gross examination, microscopically dilated ducts containing eosinophilic secretion and the absence of micropapillary pattern and cytological atypia in the lining epithelium.

MalaCards based summary : Breast Cystic Hypersecretory Carcinoma, also known as cystic hypersecretory duct carcinoma of the breast, is related to in situ carcinoma and ductal carcinoma in situ. An important gene associated with Breast Cystic Hypersecretory Carcinoma is TG (Thyroglobulin), and among its related pathways/superpathways are Bladder cancer and Adherens junction. Affiliated tissues include breast, thyroid and ovary, and related phenotype is digestive/alimentary.

Related Diseases for Breast Cystic Hypersecretory Carcinoma

Diseases related to Breast Cystic Hypersecretory Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 in situ carcinoma 30.2 KRT5 ERBB2 CDH1
2 ductal carcinoma in situ 29.9 KRT5 ERBB2 CDH1
3 breast ductal carcinoma 29.9 KRT5 ERBB2 CDH1
4 breast disease 10.3
5 breast cancer 10.2
6 rare tumor 10.2
7 acute thyroiditis 10.2 TG LALBA
8 middle ear adenocarcinoma 10.1 TG KRT5
9 pregnancy adenoma 10.1 LALBA KRT5
10 middle ear carcinoma 10.1 TG KRT5
11 uterus leiomyosarcoma 10.1 TG KRT5
12 breast secretory carcinoma 10.1 LALBA KRT5
13 suppurative thyroiditis 10.1 TG KRT5
14 adenoid squamous cell carcinoma 10.1 KRT5 CDH1
15 scirrhous adenocarcinoma 10.0 ERBB2 CDH1
16 lipid-rich breast carcinoma 10.0 KRT5 ERBB2
17 breast squamous cell carcinoma 10.0 KRT5 ERBB2
18 apocrine adenocarcinoma 10.0 KRT5 ERBB2
19 breast papillary carcinoma 10.0 KRT5 ERBB2
20 breast metaplastic carcinoma 10.0 KRT5 ERBB2
21 breast mucinous carcinoma 10.0 KRT5 ERBB2
22 breast sarcoma 10.0 KRT5 ERBB2
23 breast malignant phyllodes tumor 10.0 KRT5 ERBB2
24 breast osteosarcoma 10.0 KRT5 ERBB2
25 breast neuroendocrine neoplasm 10.0 ERBB2 CDH1
26 intraductal breast benign neoplasm 10.0 KRT5 ERBB2
27 synchronous bilateral breast carcinoma 10.0 KRT5 ERBB2
28 mammary paget's disease 10.0 LALBA ERBB2
29 cribriform carcinoma 10.0 KRT5 ERBB2
30 immature teratoma of ovary 10.0 TG CEACAM5
31 microglandular adenosis 10.0 ERBB2 CDH1
32 intraductal papilloma 10.0 KRT5 ERBB2
33 papillary thymic adenocarcinoma 10.0 TG CEACAM5
34 inflammatory breast carcinoma 10.0 ERBB2 CDH1
35 sebaceous adenocarcinoma 10.0 KRT5 ERBB2
36 thyroid angiosarcoma 10.0 TG CEACAM5
37 esophagus adenocarcinoma 10.0 ERBB2 CDH1
38 adenoid basal cell carcinoma 9.9 LALBA CEACAM5
39 ovarian benign neoplasm 9.9 TG CEACAM5
40 adenosquamous carcinoma 9.9 KRT5 CEACAM5
41 papillary adenoma 9.9 KRT5 CEACAM5
42 ovarian germ cell cancer 9.9 TG CEACAM5
43 mucoepidermoid esophageal carcinoma 9.9 KRT5 CEACAM5
44 ureter adenocarcinoma 9.9 KRT5 CEACAM5
45 salivary gland disease 9.9 KRT5 ERBB2
46 malignant acrospiroma 9.9 KRT5 CEACAM5
47 gallbladder squamous cell carcinoma 9.9 KRT5 CEACAM5
48 thymus adenocarcinoma 9.9 KRT5 CEACAM5
49 cutaneous mucoepidermoid carcinoma 9.9 KRT5 CEACAM5
50 external ear carcinoma 9.9 KRT5 CEACAM5

Graphical network of the top 20 diseases related to Breast Cystic Hypersecretory Carcinoma:



Diseases related to Breast Cystic Hypersecretory Carcinoma

Symptoms & Phenotypes for Breast Cystic Hypersecretory Carcinoma

MGI Mouse Phenotypes related to Breast Cystic Hypersecretory Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.92 CDH1 ERBB2 KRT5 TG

Drugs & Therapeutics for Breast Cystic Hypersecretory Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Cystic Hypersecretory Carcinoma

Genetic Tests for Breast Cystic Hypersecretory Carcinoma

Anatomical Context for Breast Cystic Hypersecretory Carcinoma

MalaCards organs/tissues related to Breast Cystic Hypersecretory Carcinoma:

40
Breast, Thyroid, Ovary, Colon, Lung, Skin, Thymus

Publications for Breast Cystic Hypersecretory Carcinoma

Articles related to Breast Cystic Hypersecretory Carcinoma:

# Title Authors PMID Year
1
Sonographic findings in a patient with cystic hypersecretory duct carcinoma of the breast. 61
14705175 2004
2
Cystic hypersecretory duct carcinoma of the breast: report of two cases. 61
12014880 2002
3
Cystic Hypersecretory Duct Carcinoma of the Breast. 61
11348378 2000
4
Diagnosing invasive cystic hypersecretory duct carcinoma of the breast with fine needle aspiration cytology. A case report. 61
10097724 1999
5
Cystic hypersecretory duct carcinoma of the breast. Report of a case with fine-needle aspiration. 61
2833875 1988
6
Cystic hypersecretory hyperplasia and cystic hypersecretory duct carcinoma of the breast. Pathology, therapy, and follow-up of 39 patients. 61
2832048 1988
7
Cystic hypersecretory duct carcinoma of the breast. 61
6320685 1984

Variations for Breast Cystic Hypersecretory Carcinoma

Cosmic variations for Breast Cystic Hypersecretory Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM91859752 KRAS breast,NS,carcinoma,micropapillary c.35G>T p.G12V 12:25245350-25245350 12
2 COSM87804055 KRAS breast,NS,carcinoma,micropapillary c.35G>T p.G12V 12:25245350-25245350 12
3 COSM134990158 KRAS breast,NS,carcinoma,micropapillary c.35G>T p.G12V 12:25245350-25245350 12
4 COSM134614978 KRAS breast,NS,carcinoma,micropapillary c.35G>T p.G12V 12:25245350-25245350 12

Expression for Breast Cystic Hypersecretory Carcinoma

Search GEO for disease gene expression data for Breast Cystic Hypersecretory Carcinoma.

Pathways for Breast Cystic Hypersecretory Carcinoma

Pathways related to Breast Cystic Hypersecretory Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.02 ERBB2 CDH1
2 10.81 ERBB2 CDH1
3 10.11 ERBB2 CDH1

GO Terms for Breast Cystic Hypersecretory Carcinoma

Sources for Breast Cystic Hypersecretory Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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