MCID: BRS053
MIFTS: 51

Breast Fibroadenoma

Categories: Cancer diseases, Endocrine diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Breast Fibroadenoma

MalaCards integrated aliases for Breast Fibroadenoma:

Name: Breast Fibroadenoma 12 55 15
Fibroadenoma 12 55 44 15 73
Juvenile Fibroadenoma of Breast 12 73
Fibroadenoma of Breast 12 73
Complex Fibroadenoma of Breast 12
Fibroadenoma of the Breast 29
Cellular Fibroadenoma 12
Juvenile Fibroadenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1618
ICD10 33 D24
MeSH 44 D018226
SNOMED-CT 68 46212000 65877006

Summaries for Breast Fibroadenoma

Disease Ontology : 12 A breast benign neoplasm comprised of fibrous and glandoular tissues located in breast.

MalaCards based summary : Breast Fibroadenoma, also known as fibroadenoma, is related to in situ carcinoma and gynecomastia. An important gene associated with Breast Fibroadenoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Signaling by ERBB4 and Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Tamoxifen and Estrogen Receptor Modulators have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and lung, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 76 Fibroadenomas, are benign breast tumours characterized by an admixture of stromal and epithelial tissue.... more...

Related Diseases for Breast Fibroadenoma

Diseases in the Breast Fibroadenoma family:

Multiple Fibroadenomas of the Breast

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)
# Related Disease Score Top Affiliating Genes
1 in situ carcinoma 30.6 ERBB2 ESR1 KRT14 PGR
2 gynecomastia 30.2 CYP19A1 ESR1 PGR
3 pregnancy adenoma 30.1 KRT14 KRT8 MED12
4 breast osteosarcoma 30.1 ERBB2 KRT8
5 benign breast phyllodes tumor 30.1 MKI67 MME PGR
6 lobular neoplasia 29.9 ERBB2 ESR1
7 ductal carcinoma in situ 29.8 CYP19A1 ERBB2 ESR1 KRT14 KRT8 MKI67
8 apocrine adenocarcinoma 29.8 ERBB2 ESR1 KRT15 PGR
9 breast ductal carcinoma 29.8 ERBB2 ESR1 KRT8 NME1 PGR
10 breast disease 29.7 CYP19A1 ERBB2 ESR1 MKI67 PGR
11 adenomyosis 29.7 CYP19A1 ESR1 MME PGR
12 myoma 29.7 CYP19A1 ESR1 HMGA2 MED12 PGR
13 adenoid cystic carcinoma 29.4 ERBB2 KRT14 MKI67 PGR RASSF1
14 breast cancer 29.2 CYP19A1 ERBB2 ESR1 KRT14 KRT8 MKI67
15 multiple fibroadenomas of the breast 11.2
16 breast pericanalicular fibroadenoma 11.2
17 breast intracanalicular fibroadenoma 11.2
18 breast giant fibroadenoma 11.2
19 breast fibroadenosis 11.2
20 scirrhous adenocarcinoma 10.3 ERBB2 PGR
21 breast apocrine carcinoma 10.3 ERBB2 PGR
22 adenoma 10.3
23 intracystic papillary adenoma 10.3 ERBB2 PGR
24 breast metaplastic carcinoma 10.3 ERBB2 PGR
25 progesterone-receptor negative breast cancer 10.3 ERBB2 PGR
26 bizarre leiomyoma 10.3 MED12 PGR
27 comedo carcinoma 10.3 ERBB2 ESR1
28 vestibular gland benign neoplasm 10.3 ESR1 PGR
29 bartholin's gland adenoma 10.3 ESR1 PGR
30 vulvar syringoma 10.3 ESR1 PGR
31 lung leiomyoma 10.3 ESR1 PGR
32 vulvar benign neoplasm 10.3 ESR1 PGR
33 trigonitis 10.2 ESR1 PGR
34 vulvar leiomyoma 10.2 ESR1 PGR
35 mixed fibrolamellar hepatocellular carcinoma 10.2 ERBB2 RASSF1
36 benign metastasizing leiomyoma 10.2 CYP19A1 PGR
37 bartholin's gland benign neoplasm 10.2 ESR1 PGR
38 uterine body mixed cancer 10.2 ERBB2 PGR
39 progesterone resistance 10.2 ESR1 PGR
40 endometrial squamous cell carcinoma 10.2 ESR1 PGR
41 cribriform carcinoma 10.2 ESR1 PGR
42 microglandular adenosis 10.2 ERBB2 PGR
43 adenoid basal cell carcinoma 10.2 ESR1 PGR
44 deep angioma 10.2 ESR1 PGR
45 synchronous bilateral breast carcinoma 10.2 ESR1 PGR
46 female reproductive endometrioid cancer 10.2 ESR1 PGR
47 hidrocystoma 10.2 KRT15 KRT8
48 intramuscular hemangioma 10.2 ESR1 PGR
49 glycogen-rich clear cell breast carcinoma 10.2 ESR1 PGR
50 breast squamous cell carcinoma 10.2 ERBB2 KRT14

Graphical network of the top 20 diseases related to Breast Fibroadenoma:



Diseases related to Breast Fibroadenoma

Symptoms & Phenotypes for Breast Fibroadenoma

MGI Mouse Phenotypes related to Breast Fibroadenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.02 CYP19A1 ERBB2 ESR1 KRT14 KRT15 KRT8
2 cardiovascular system MP:0005385 10.01 CYP19A1 ERBB2 ESR1 KRT8 MED12 NGFR
3 digestive/alimentary MP:0005381 9.97 CYP19A1 ERBB2 ESR1 KRT14 KRT15 KRT8
4 integument MP:0010771 9.86 CYP19A1 ERBB2 ESR1 KRT14 MME NGFR
5 liver/biliary system MP:0005370 9.7 CYP19A1 ESR1 KRT8 MME NGFR NME1
6 neoplasm MP:0002006 9.43 ERBB2 ESR1 KRT14 NME1 PGR RASSF1
7 normal MP:0002873 9.23 CYP19A1 ERBB2 ESR1 MED12 MKI67 NGFR

Drugs & Therapeutics for Breast Fibroadenoma

Drugs for Breast Fibroadenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamoxifen Approved Phase 4,Phase 2 10540-29-1 2733526
2 Estrogen Receptor Modulators Phase 4,Phase 2
3 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
4 Antineoplastic Agents, Hormonal Phase 4,Phase 2
5 Anti-Inflammatory Agents Phase 4
6 Efamol Phase 4
7 Analgesics, Non-Narcotic Phase 4
8 Anti-Inflammatory Agents, Non-Steroidal Phase 4
9 Selective Estrogen Receptor Modulators Phase 4,Phase 2
10 Analgesics Phase 4,Phase 2
11 Dermatologic Agents Phase 4
12 Hormone Antagonists Phase 4,Phase 2
13 Estrogens Phase 4,Phase 2
14 Hormones Phase 4,Phase 2
15 Bone Density Conservation Agents Phase 4,Phase 2
16 Antirheumatic Agents Phase 4
17 Antimetabolites Phase 4
18 Peripheral Nervous System Agents Phase 4,Phase 2
19 Hypolipidemic Agents Phase 4
20 Evening Primrose Phase 4
21 Estrogen Receptor Antagonists Phase 4,Phase 2
22 Estrogen Antagonists Phase 4,Phase 2
23 Lipid Regulating Agents Phase 4
24
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
25
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
26
Iodine Approved, Investigational Phase 2 7553-56-2 807
27
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
28 cadexomer iodine Phase 2
29 BB 1101 Phase 2
30 Immunologic Factors
31 Autoantibodies
32 Immunoglobulins
33 Antibodies
34 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast Cancer Completed NCT00999921 Phase 4 Tamoxifen;Evening Primrose Oil
2 MR Guided Focused Ultrasound Surgery in the Treatment of Breast Fibroadenomas Terminated NCT00147108 Phase 3
3 Analgesic Efficacy of Pulsed Radiofrequency in Non-cyclic Mastalgia Recruiting NCT03715413 Phase 2 Tamoxifen
4 Blood Test for Breast Cancer Associated Auto Antibodies - Improvement of Octava Blood Test Unknown status NCT02066025
5 High Intensity Focused Ultrasound (HIFU) to Treat Breast Fibroadenoma Completed NCT01422629 Not Applicable
6 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound Completed NCT02078011 Not Applicable
7 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU) Completed NCT03022695 Not Applicable
8 Feasibility Study Assessing the Treatment of Fibroadenomata With a Circumferential Sonication Treatment With HIFU Completed NCT02139683 Not Applicable
9 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU) Completed NCT02011919 Not Applicable
10 ICE-SENSE™ Cryotherapy for Breast Fibroadenoma Trial Completed NCT00910312 Not Applicable
11 Synthetic Aperture Radar Detection of Breast Tumours Completed NCT02493595
12 Optical Tomography With Ultrasound Guidance Completed NCT00908609
13 Diagnostic Outcomes Of The Females Presenting With Breast Lump In Surgical Department Services Hospital Lahore Completed NCT03590990
14 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU) Recruiting NCT03742401 Not Applicable
15 Treatment of Breast Fibroadenoma Targeted Tissue With HIFU Recruiting NCT03044054 Not Applicable
16 Treatment of Breast Fibroadenoma With FastScan HIFU Recruiting NCT02488655 Not Applicable
17 Case Collection Study in the Evaluation of Doubling Time Rates in Non-Suspicious Breast Masses Using QT Ultrasound Technology Recruiting NCT03470051
18 American Breast Laser Ablation Therapy Evaluation Recruiting NCT00807924
19 Autoantibodies in Breast Cancer Detection Recruiting NCT03623945
20 Evaluation of Virtual Touch Tissue Imaging Quantification (VTIQ - 2D-SWE) in the Assessment of BI-RADS® 3 and 4 Lesions Recruiting NCT02638935 Not Applicable
21 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU) Active, not recruiting NCT01331954 Not Applicable
22 Multimode Laser Optoacoustic Ultrasonic Tomography System for Breast Cancer Care - LOUIS-3D Breast Study Active, not recruiting NCT01755130 Not Applicable
23 London Investigation Into diElectric Scanning of Lesions Not yet recruiting NCT03302819 Not Applicable

Search NIH Clinical Center for Breast Fibroadenoma

Cochrane evidence based reviews: fibroadenoma

Genetic Tests for Breast Fibroadenoma

Genetic tests related to Breast Fibroadenoma:

# Genetic test Affiliating Genes
1 Fibroadenoma of the Breast 29

Anatomical Context for Breast Fibroadenoma

MalaCards organs/tissues related to Breast Fibroadenoma:

41
Breast, Bone, Lung, Skin, Smooth Muscle, Ovary, Thymus

The Foundational Model of Anatomy Ontology organs/tissues related to Breast Fibroadenoma:

19
Breast

Publications for Breast Fibroadenoma

Articles related to Breast Fibroadenoma:

(show top 50) (show all 546)
# Title Authors Year
1
Super-Giant Juvenile Breast Fibroadenoma: World's First Case. ( 29544595 )
2018
2
An application study of low-dose computed tomography perfusion imaging (LDCTPI) in breast cancer and breast fibroadenoma. ( 29733054 )
2018
3
High intensity focused ultrasound (HIFU) for the treatment of symptomatic breast fibroadenoma. ( 30204024 )
2018
4
Fibroadenoma-like Lesion of the Vagina: A Description of 2 Cases of a Previously Unreported Entity. ( 28463909 )
2018
5
B acute lymphoblastic leukemia/lymphoma involving pre-existing fibroadenoma of the breast. ( 28608564 )
2018
6
Sonographic features that can be used to differentiate between small triple-negative breast cancer and fibroadenoma. ( 28870060 )
2018
7
Secretory Carcinoma Arising in a Fibroadenoma: A Brief Case Report. ( 28994273 )
2018
8
Progression of Fibroadenoma to Malignant Phyllodes Tumour in a 14-Year Female. ( 29290198 )
2018
9
Comparison of Ultrasound Elastography and Color Doppler Ultrasonography for Distinguishing Small Triple-Negative Breast Cancer From Fibroadenoma. ( 29424448 )
2018
10
Oncoplastic Reduction Pattern Technique Following Removal of Giant Fibroadenoma. ( 29467913 )
2018
11
Diagnosis and imaging characteristics of a juvenile fibroadenoma in a 2-year-old patient: a case report. ( 29487631 )
2018
12
Juvenile fibroadenoma. ( 29743752 )
2018
13
Aesthetic Unit Boundary Approach to Large Fibroadenoma Resection. ( 29746281 )
2018
14
Recurrent juvenile fibroadenoma of the breast in an adolescent: A case report. ( 29768365 )
2018
15
Case Report and Review of Adolescent Atypical Ductal Hyperplasia and Juvenile Fibroadenoma: How Do We Assess and Manage Future Risk? ( 30131245 )
2018
16
Educational Case: Fibroadenoma of the Breast. ( 30159386 )
2018
17
Radiomics of US texture features in differential diagnosis between triple-negative breast cancer and fibroadenoma. ( 30202040 )
2018
18
Breast MRI findings of fibroadenoma with hemorrhagic infarction. ( 30240064 )
2018
19
Distinction between phyllodes tumor and fibroadenoma in breast ultrasound using deep learning image analysis. ( 30258856 )
2018
20
Fine needle aspiration biopsy cytology of phyllodes tumour and fibroadenoma: A cytomorphological study of 104 cases. ( 30284391 )
2018
21
HIFU treatment for fibroadenoma - a clinical study at National Scientific Research Centre, Astana, Kazakhstan. ( 30317269 )
2018
22
Intermediate and long-term outcomes of fibroadenoma excision in adolescent and young adult patients. ( 30444280 )
2018
23
Management of Palpable Pediatric Breast Masses With Ultrasound Characteristics of Fibroadenoma: A More Conservative Approach. ( 30476459 )
2018
24
Patients With Invasive Ductal Carcinoma Have Reduced Levels of Decorin Expression in Their Breast Tissue Compared to Patients With Fibroadenoma While Plasma Decorin Remains Unchanged. ( 30551691 )
2018
25
An Evaluation of Ultrasound Features of Breast Fibroadenoma. ( 29285483 )
2017
26
Breast fibroadenoma with pseudoangiomatous (PASH-like) stroma. ( 28777747 )
2017
27
Minimally Invasive Breast Fibroadenoma Excision Using an Ultrasound-Guided Vacuum-Assisted Biopsy Device. ( 28331240 )
2017
28
Breast Fibroadenoma With Increased Activity on 68Ga DOTATATE PET/CT. ( 27879489 )
2017
29
Primary Infarction of Breast Fibroadenoma in the Absence of Pregnancy or Lactation. ( 27670396 )
2017
30
Advantages of the modified double ring areolar incision over the traditional areolar incision in multicentric breast fibroadenoma surgery. ( 28574223 )
2017
31
Iatrogenic Arteriovenous Fistula of the Breast: A Rare Complication Following Ultrasound-guided Core Biopsy of Fibroadenoma. ( 28191703 )
2017
32
Long-term efficacy of ultrasound-guided high-intensity focused ultrasound treatment of breast fibroadenoma. ( 28331611 )
2017
33
Partial Breast Reconstruction with Goldilocks Technique After Excision of Giant Fibroadenoma: A Case Report. ( 28203501 )
2017
34
Fibroadenoma progress to ductal carcinoma in situ, infiltrating ductal carcinoma and lymph node metastasis? Report an unusual case. ( 28584621 )
2017
35
Invasive Papillary Carcinoma of the Male Breast Misdiagnosed as Fibroadenoma on FNAB. ( 28384872 )
2017
36
Extrathyroidal Radioiodine Accumulation in a Fibroadenoma of the Breast. ( 27801741 )
2017
37
Cytokine profiles of tumor supernatants in invasive ductal cancer and fibroadenoma of the breast and its relationship with VEGF-A expression in the tumors. ( 27903846 )
2017
38
Surgical excision of the breast giant fibroadenoma under regional anesthesia by Pecs II and internal intercostal plane block: a case report and brief technical description: a case report. ( 28184271 )
2017
39
Giant Juvenile Fibroadenoma in a 12-Year-Old Girl: Ultrasonography, Elastography, Clinical, and Pathology Findings of This Rare Type of Fibroadenoma. ( 28301375 )
2017
40
Fibroadenoma With Pleomorphic Stromal Giant Cells: It's Not as Bad as It Looks! ( 28413897 )
2017
41
Fibroadenoma in Axillary Ectopic Breast Tissue Mimicking Lymphadenopathy. ( 28511397 )
2017
42
Fibroadenoma in adolescent females after living donor liver transplantation. ( 28556594 )
2017
43
Giant juvenile fibroadenoma in a 9-year-old: A case presentation and review of the current literature. ( 28655118 )
2017
44
Cytological Criteria to Distinguish Phyllodes Tumour of the Breast from Fibroadenoma. ( 28738381 )
2017
45
Differentiation of secondary involvement of the breast by lymphoreticular malignancy from fibroadenoma using ultrasound elastography: A report of two cases. ( 28744086 )
2017
46
Bilateral Giant Juvenile Fibroadenoma of Breast. ( 28764179 )
2017
47
Hypoluteoidism in a dog associated with recurrent mammary fibroadenoma stimulated by progestin therapy. ( 28877731 )
2017
48
A case report of juvenile giant fibroadenoma of the breast: How common? ( 28974914 )
2017
49
Phyllodes tumors with and without fibroadenoma-like areas display distinct genomic features and may evolve through distinct pathways. ( 29043292 )
2017
50
Results of Short-Term Follow-Up in BI-RADS 3 and 4a Breast Lesions with a Histological Diagnosis of Fibroadenoma at Percutaneous Needle Biopsy. ( 29070987 )
2017

Variations for Breast Fibroadenoma

Expression for Breast Fibroadenoma

Search GEO for disease gene expression data for Breast Fibroadenoma.

Pathways for Breast Fibroadenoma

Pathways related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.37 ERBB2 ESR1 PGR
2 11 KRT8 MKI67 MME
3 9.23 CYP19A1 ESR1

GO Terms for Breast Fibroadenoma

Cellular components related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.73 ERBB2 ESR1 HMGA2 KRT14 KRT15 KRT8
2 intermediate filament GO:0005882 8.92 KRT14 KRT15 KRT8 NME1

Biological processes related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 uterus development GO:0060065 9.32 CYP19A1 ESR1
2 androgen metabolic process GO:0008209 9.26 CYP19A1 ESR1
3 intracellular steroid hormone receptor signaling pathway GO:0030518 9.16 ESR1 MED12
4 cornification GO:0070268 9.13 KRT14 KRT15 KRT8
5 mammary gland development GO:0030879 8.8 CYP19A1 NME1 PGR

Molecular functions related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.44 ERBB2 ESR1 HMGA2 KRT14 KRT15 KRT8

Sources for Breast Fibroadenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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