MCID: BRS053
MIFTS: 49

Breast Fibroadenoma

Categories: Cancer diseases, Endocrine diseases, Genetic diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Breast Fibroadenoma

MalaCards integrated aliases for Breast Fibroadenoma:

Name: Breast Fibroadenoma 12 55 15
Fibroadenoma 12 55 44 15 17 72
Juvenile Fibroadenoma of Breast 12 72
Fibroadenoma of Breast 12 72
Complex Fibroadenoma of Breast 12
Cellular Fibroadenoma 12
Juvenile Fibroadenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1618
MeSH 44 D018226
SNOMED-CT 68 46212000 65877006
ICD10 33 D24
UMLS 72 C0178421 C0206650 C0346158 more

Summaries for Breast Fibroadenoma

Disease Ontology : 12 A breast benign neoplasm comprised of fibrous and glandoular tissues located in breast.

MalaCards based summary : Breast Fibroadenoma, also known as fibroadenoma, is related to pleomorphic lipoma and gynecomastia. An important gene associated with Breast Fibroadenoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Circadian entrainment and Thyroid hormone signaling pathway. The drugs Tamoxifen and Selective Estrogen Receptor Modulators have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and prostate, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 75 Fibroadenomas, are benign breast tumours characterized by an admixture of stromal and epithelial tissue.... more...

Related Diseases for Breast Fibroadenoma

Diseases in the Breast Fibroadenoma family:

Multiple Fibroadenomas of the Breast

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 275)
# Related Disease Score Top Affiliating Genes
1 pleomorphic lipoma 31.1 PGR HMGA2
2 gynecomastia 31.0 PGR ESR1 CYP19A1
3 breast osteosarcoma 30.8 KRT8 ERBB2
4 tubular adenocarcinoma 30.8 PGR ESR1 ERBB2
5 in situ carcinoma 30.7 PGR KRT14 ESR1 ERBB2
6 pregnancy adenoma 30.6 MED12 KRT8 KRT14
7 leiomyoma, uterine 30.6 PGR HMGA2 ESR1
8 hidrocystoma 30.5 KRT8 KRT15
9 prostatic hypertrophy 30.5 PGR ESR1 CYP19A1
10 breast carcinoma in situ 30.5 PGR ESR1 ERBB2
11 myoma 30.3 PGR MED12 HMGA2 ESR1 CYP19A1
12 carcinosarcoma 30.2 PGR MME ERBB2
13 benign breast phyllodes tumor 30.2 PGR MME MKI67
14 microglandular adenosis 30.2 PGR ERBB2
15 apocrine adenocarcinoma 30.2 PGR KRT15 ESR1 ERBB2
16 ovarian disease 30.2 PGR ESR1 CYP19A1
17 breast disease 29.8 PGR MKI67 ESR1 ERBB2 CYP19A1 CTSD
18 adenomyosis 29.4 PGR MME ESR1 CYP19A1
19 adenoid cystic carcinoma 29.4 RASSF1 PGR MKI67 KRT14 ERBB2
20 endometrial stromal sarcoma 29.4 PGR MME ESR1 CYP19A1
21 breast ductal carcinoma 29.0 PGR NME1 KRT8 ESR1 ERBB2 CTSD
22 ductal carcinoma in situ 28.9 PGR MKI67 KRT8 KRT14 ESR1 ERBB2
23 leiomyoma 28.6 PGR MME MKI67 MED12 HMGA2 ESR1
24 breast cancer 26.6 RASSF1 PGR NME1 MKI67 KRT8 KRT14
25 multiple fibroadenomas of the breast 11.7
26 breast pericanalicular fibroadenoma 11.4
27 breast intracanalicular fibroadenoma 11.4
28 breast giant fibroadenoma 11.4
29 breast fibroadenosis 11.4
30 breast apocrine carcinoma 10.7 PGR ERBB2
31 scirrhous adenocarcinoma 10.7 PGR ERBB2
32 intracystic papillary adenoma 10.7 PGR ERBB2
33 bartholin's gland adenoma 10.7 PGR ESR1
34 breast metaplastic carcinoma 10.7 PGR ERBB2
35 vestibular gland benign neoplasm 10.7 PGR ESR1
36 lung leiomyoma 10.7 PGR ESR1
37 vulvar syringoma 10.7 PGR ESR1
38 progesterone-receptor negative breast cancer 10.7 PGR ERBB2
39 comedo carcinoma 10.7 ESR1 ERBB2
40 vulvar leiomyoma 10.7 PGR ESR1
41 trigonitis 10.7 PGR ESR1
42 vulvar benign neoplasm 10.7 PGR ESR1
43 bizarre leiomyoma 10.6 PGR MED12
44 pleomorphic adenoma carcinoma 10.6 HMGA2 ERBB2
45 bartholin's gland benign neoplasm 10.6 PGR ESR1
46 benign metastasizing leiomyoma 10.6 PGR CYP19A1
47 mixed fibrolamellar hepatocellular carcinoma 10.6 RASSF1 ERBB2
48 cribriform carcinoma 10.6 PGR ESR1
49 endometrial squamous cell carcinoma 10.5 PGR ESR1
50 glassy cell carcinoma of the cervix 10.5 PGR ESR1 ERBB2

Graphical network of the top 20 diseases related to Breast Fibroadenoma:



Diseases related to Breast Fibroadenoma

Symptoms & Phenotypes for Breast Fibroadenoma

MGI Mouse Phenotypes related to Breast Fibroadenoma:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.21 CTSD CYP19A1 ERBB2 ESR1 HIF1A KRT14
2 homeostasis/metabolism MP:0005376 10.21 CTSD CYP19A1 ERBB2 ESR1 HIF1A KRT14
3 digestive/alimentary MP:0005381 10.19 CTSD CYP19A1 ERBB2 ESR1 HIF1A KRT14
4 cardiovascular system MP:0005385 10.18 CYP19A1 ERBB2 ESR1 HIF1A KRT8 MED12
5 growth/size/body region MP:0005378 10.16 CTSD CYP19A1 ERBB2 ESR1 HIF1A KRT14
6 endocrine/exocrine gland MP:0005379 10.13 CTSD CYP19A1 ERBB2 ESR1 HIF1A KRT14
7 immune system MP:0005387 10.1 CTSD CYP19A1 ESR1 HIF1A KRT14 KRT8
8 integument MP:0010771 10.07 CTSD CYP19A1 ERBB2 ESR1 HIF1A KRT14
9 mortality/aging MP:0010768 9.9 CTSD ERBB2 ESR1 HIF1A KRT14 KRT8
10 liver/biliary system MP:0005370 9.86 CYP19A1 ESR1 HIF1A KRT8 MME NGFR
11 limbs/digits/tail MP:0005371 9.8 ERBB2 ESR1 HIF1A MED12 NGFR PGR
12 neoplasm MP:0002006 9.5 ERBB2 ESR1 HIF1A KRT14 NME1 PGR
13 normal MP:0002873 9.28 CYP19A1 ERBB2 ESR1 HIF1A MED12 MKI67

Drugs & Therapeutics for Breast Fibroadenoma

Drugs for Breast Fibroadenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamoxifen Approved Phase 4 10540-29-1 2733526
2 Selective Estrogen Receptor Modulators Phase 4
3 Estrogens Phase 4
4 Analgesics Phase 4
5 Hormones Phase 4
6 Antineoplastic Agents, Hormonal Phase 4
7 Estrogen Receptor Modulators Phase 4
8 Hormone Antagonists Phase 4
9 Estrogen Receptor Antagonists Phase 4
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
11 Peripheral Nervous System Agents Phase 4
12 Estrogen Antagonists Phase 4
13 Bone Density Conservation Agents Phase 4
14 Anti-Inflammatory Agents Phase 4
15 Lipid Regulating Agents Phase 4
16 Anti-Inflammatory Agents, Non-Steroidal Phase 4
17 Analgesics, Non-Narcotic Phase 4
18 Hypolipidemic Agents Phase 4
19 Dermatologic Agents Phase 4
20 Evening Primrose Phase 4
21 Antimetabolites Phase 4
22 Antirheumatic Agents Phase 4
23
Evening primrose oil Investigational, Nutraceutical Phase 4 308064-97-3
24
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
25
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
26
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
27
Iodine Approved, Investigational Phase 2 7553-56-2 807
28 cadexomer iodine Phase 2
29 BB 1101 Phase 2

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 A Single Blinded Randomized Controlled Trial of the Comparative Effects of Tamoxifen and Evening Primrose Oil in Premenopausal Non-high Risk Patients With Benign Breast Disease With Respect to the Estrogen Receptor Status. Completed NCT00999921 Phase 4 Tamoxifen;Evening Primrose Oil
2 Phase 3 Study of MR Guided Focused Ultrasound Surgery in the Treatment of Breast Fibroadenomas Terminated NCT00147108 Phase 3
3 Analgesic Efficacy of Pulsed Radiofrequency in Non-cyclic Mastalgia Completed NCT03715413 Phase 2 Tamoxifen
4 High Intensity Focused Ultrasound (HIFU) to Treat Breast Fibroadenoma: a Feasibility Study. A Multicentric, Open, Uncontrolled Study Completed NCT01422629
5 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU) Completed NCT03022695
6 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU) Completed NCT02011919
7 High Intensity Focused Ultrasound for the Treatment of Fibroadenomata (HIFU-F) Completed NCT02139683
8 Evaluation of Safety and Feasibility of the ICE-SENSE™, a Cryotherapy Device for Office-based Ultrasound-guided Treatment of Breast Fibroadenoma Completed NCT00910312
9 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU): A Feasibility Study Completed NCT02078011
10 A Pilot Study Evaluation of the Efficacy of SonoVue to Detect and Characterise Breast Lesions Completed NCT00243698 SonoVue (sulphur hexafluoride microbubbles)
11 Post-CE Marking Continuing Evaluation of Multi-Static Microwave Imaging of the Female Breast in Controlled Trial to Identify Optimum Use of the MARIA Platform in the Clinical Workflow Completed NCT02493595
12 Infrared Imaging (Breast Scan IR) for Early Breast Cancer Detection Completed NCT00195026
13 Treatment of Breast Fibroadenoma Targeted Tissue With High Intensity Focused Ultrasound (HIFU) Recruiting NCT03044054
14 Treatment of Breast Fibroadenoma With FastScan High Intensity Focused Ultrasound (HIFU) Recruiting NCT02488655
15 A Prospective Multi-center Case Collection Study of Breast Imaging Examinations From Women With Non-suspicious Breast Masses to Correlate the Calculated Mass Doubling Time Using Quantitative Transmission Ultrasound (QT Ultrasound) With Mass Histology. Recruiting NCT03470051
16 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU) vS Surgery: A Prospective Randomized Study Recruiting NCT03742401
17 American Breast Laser Ablation Therapy Evaluation (ABLATE): Monitoring the Long Term Safety and Efficacy of Novilase™ Breast Interstitial Laser Therapy in Real World Application Recruiting NCT00807924
18 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU): a Feasibility Study Active, not recruiting NCT01331954
19 Efficacy, Safety, Cosmesis and Patient Satisfaction With Vacuum-Assisted Percutaneous Excision (VAPE) Compared With Standard Surgical Excision (X) of Non-malignant, Borderline or High-risk Breast Lesions: A Randomized Controlled Trial Not yet recruiting NCT03868475

Search NIH Clinical Center for Breast Fibroadenoma

Cochrane evidence based reviews: fibroadenoma

Genetic Tests for Breast Fibroadenoma

Anatomical Context for Breast Fibroadenoma

MalaCards organs/tissues related to Breast Fibroadenoma:

41
Breast, Lymph Node, Prostate, Lung, Bone, Smooth Muscle, Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Breast Fibroadenoma:

19
Breast

Publications for Breast Fibroadenoma

Articles related to Breast Fibroadenoma:

(show top 50) (show all 2427)
# Title Authors PMID Year
1
Progesterone receptors A and B and estrogen receptor alpha expression in normal breast tissue and fibroadenomas. 9 38
19367380 2009
2
Analysis of human mammary fibroadenoma by Ki-67 index in the follicular and luteal phases of menstrual cycle. 9 38
19317807 2009
3
Mean nuclear area and metallothionein expression in ductal breast tumors: correlation with estrogen receptor status. 9 38
18227734 2008
4
High prevalence of HER-2/neu overexpression in female breast cancer among an Iraqi population exposed to depleted uranium. 9 38
19008567 2008
5
Adenoma of anogenital mammary-like glands. 9 38
17845825 2007
6
Expression of nm23, MMP-2, TIMP-2 in breast neoplasm in Zhengzhou Center Hospital, China. 9 38
17642161 2007
7
[HIF-1alpha expression and relationship involving tumor cell proliferation and angiogenesis in human breast carcinoma]. 9 38
17294729 2007
8
Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast. 9 38
16554735 2006
9
A polymorphism at codon 133 of the tumor suppressor RASSF1A is associated with tumorous alteration of the breast. 9 38
15942659 2005
10
Expression of hypoxia-inducible factor (HIF-1alpha), VEGF-C and VEGF-D in non-invasive and invasive breast ductal carcinomas. 9 38
16080559 2005
11
Estrogen receptor-alpha, bcl-2 and c-myc gene expression in fibroadenomas and adjacent normal breast: association with nodule size, hormonal and reproductive features. 9 38
15763593 2005
12
Metaphase and interphase cytogenetics in fibroadenomas of the breast. 9 38
15646810 2004
13
Extracellular DNA in breast cancer: Cell-surface-bound, tumor-derived extracellular DNA in blood of patients with breast cancer and nonmalignant tumors. 9 38
15251963 2004
14
[Hypermethylation of syk gene in promoter region is associated with oncogenesis, metastasis of breast carcinoma]. 9 38
15059510 2004
15
[Expression of tyrosine kinase Syk in breast cancer and their clinical significance]. 9 38
15062056 2004
16
The effect of tamoxifen on PCNA expression in fibroadenomas. 9 38
12846865 2003
17
Naked nuclei revisited: p63 Immunoexpression. 9 38
12203858 2002
18
Proliferating activity in differential diagnosis of benign phyllodes tumor and cellular fibroadenomas: is it helpful? 9 38
11692149 2001
19
A comparison of the pattern of cathepsin-D expression in fibroadenoma, fibrocystic disease, preinvasive and invasive ductal breast carcinoma. 9 38
10503271 1999
20
The expression and localization of fibroblast growth factor-1 (FGF-1) and FGF receptor-1 (FGFR-1) in human breast cancer. 9 38
9756721 1998
21
Immunohistochemical study of TGF-alpha, TGF-beta1, EGFR, and IGF-1 expression in human breast carcinoma. 9 38
9346175 1997
22
Analysis of polypeptide expression in benign and malignant human breast lesions. 9 38
9150945 1997
23
Analysis of polypeptide expression in benign and malignant human breast lesions: down-regulation of cytokeratins. 9 38
8932346 1996
24
Mammary fibroadenoma and some phyllodes tumour stroma are composed of CD34+ fibroblasts and factor XIIIa+ dendrophages. 9 38
8951485 1996
25
Production of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human breast carcinomas. 9 38
8766524 1996
26
A fibroadenoma with a t(4;12) (q27;q15) affecting the HMGI-C gene, a member of the high mobility group protein gene family. 9 38
8739083 1996
27
Progression of fibroadenoma to phyllodes tumor demonstrated by clonal analysis. 9 38
8625047 1995
28
Reduction of telomeric length and c-erbB-2 gene amplification in human breast cancer, fibroadenoma, and gynecomastia. Relationship to histologic grade and clinical parameters. 9 38
7911069 1994
29
Glial fibrillary acidic protein immunoreactivity in normal and diseased human breast. 9 38
1708927 1991
30
Antigenic profile of mammary fibroadenoma and cystosarcoma phyllodes. A study using antibodies to estrogen- and progesterone receptors and to a panel of cell surface molecules. 9 38
2174150 1990
31
Clinicopathologic Features and Genetic Alterations of a Primary Osteosarcoma of the Uterine Corpus. 38
29629977 2019
32
High prevalence of benign mammary tumors in a rat model of polycystic ovary syndrome during postmenopausal period. 38
30990105 2019
33
Ectopic breast tissue lesion in axilla: Cytology report of two cases. 38
30974022 2019
34
Our 20-Year Institutional Experience with Surgical Approach for Breast Hamartomas. 38
31312793 2019
35
Cutaneous spindle cell adenolipoma with eccrine and apocrine differentiation. 38
31329294 2019
36
Breast Cancer Assessment With Pulse-Echo Speed of Sound Ultrasound From Intrinsic Tissue Reflections: Proof-of-Concept. 38
30913054 2019
37
Effect of Converting From Calcineurin Inhibitor- to Sirolimus-Based Immunosuppressant Regimen on Breast Fibroadenoma Among Kidney Transplant Patients. 38
31256869 2019
38
[Value of shear wave elastrography image classification in the diagnosis of breast masses]. 38
31357843 2019
39
Can Radiologist and Pathologist Reach The Truth Together in The Diagnosis of Benign Fibroepithelial Lesions? 38
31312794 2019
40
Evaluating the glycophenotype on breast cancer tissues with quantum dots-Cramoll lectin conjugates. 38
31306700 2019
41
Evaluation of Serum Integrin αvβ3 & Vitronectin in the Early Diagnosis of Breast Cancer. 38
31307158 2019
42
Accuracy and clinical implications of pre-operative breast core needle biopsy diagnoses of fibroepithelial neoplasms and sarcomatoid carcinomas. 38
31332664 2019
43
Low-dose imaging technique (LITE) MRI: initial experience in breast imaging. 38
31271535 2019
44
The Comparison of RhoC and PI3K Gene Expression on the Breast Cancer Tissue and Benign Tumour Tissue. 38
31406528 2019
45
Malignant Phyllodes Tumor Recurrence in the Pleural Cavity via the Deep Inferior Epigastric Perforator Flap and Internal Mammary Vessel Bundle: A Case Report. 38
30882414 2019
46
A case-control study of Metallothionein-1 expression in breast cancer and breast fibroadenoma. 38
31092851 2019
47
A Unique Four-Point Approach for Removal of Giant Breast Fibroadenoma With Marked Asymmetry: A Modified Round Block Technique. 38
31070071 2019
48
Incidence of and Risk Factors for Histologically Confirmed Solid Benign Tumors Among Long-term Survivors of Childhood Cancer. 38
30920605 2019
49
Robot assisted radical nephrectomy + hysterectomy and specimen retrieval per vaginum (NOSE). 38
30735334 2019
50
Enlarging biopsy-proven fibroadenoma: Is surgical excision necessary? 38
31103907 2019

Variations for Breast Fibroadenoma

Expression for Breast Fibroadenoma

Search GEO for disease gene expression data for Breast Fibroadenoma.

Pathways for Breast Fibroadenoma

GO Terms for Breast Fibroadenoma

Cellular components related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.73 RASSF1 PGR NME1 MKI67 MED12 KRT8
2 intermediate filament GO:0005882 8.92 NME1 KRT8 KRT15 KRT14

Biological processes related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 uterus development GO:0060065 9.37 ESR1 CYP19A1
2 cornification GO:0070268 9.33 KRT8 KRT15 KRT14
3 androgen metabolic process GO:0008209 9.26 ESR1 CYP19A1
4 negative regulation of gene expression GO:0010629 9.26 PGR NME1 HIF1A ESR1
5 intracellular steroid hormone receptor signaling pathway GO:0030518 9.02 ESR1
6 mammary gland development GO:0030879 8.8 PGR NME1 CYP19A1

Molecular functions related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.5 RASSF1 PGR NME1 NGFR MME MKI67
2 enzyme binding GO:0019899 9.46 PGR NME1 HIF1A ESR1
3 transcription factor binding GO:0008134 9.26 MED12 HMGA2 HIF1A ESR1

Sources for Breast Fibroadenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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