MCID: BRS053
MIFTS: 48

Breast Fibroadenoma

Categories: Cancer diseases, Endocrine diseases, Genetic diseases

Aliases & Classifications for Breast Fibroadenoma

MalaCards integrated aliases for Breast Fibroadenoma:

Name: Breast Fibroadenoma 12 54 15
Fibroadenoma 12 54 43 15 17 71
Juvenile Fibroadenoma of Breast 12 71
Fibroadenoma of Breast 12 71
Complex Fibroadenoma of Breast 12
Cellular Fibroadenoma 12
Juvenile Fibroadenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1618
MeSH 43 D018226
SNOMED-CT 67 46212000 65877006
ICD10 32 D24
UMLS 71 C0178421 C0206650 C0346158 more

Summaries for Breast Fibroadenoma

Disease Ontology : 12 A breast benign neoplasm comprised of fibrous and glandoular tissues located in breast.

MalaCards based summary : Breast Fibroadenoma, also known as fibroadenoma, is related to papilloma and carcinosarcoma. An important gene associated with Breast Fibroadenoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways are Pathways in cancer and Chromatin Regulation / Acetylation. The drugs Tamoxifen and Estrogens have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and thyroid, and related phenotypes are cellular and cardiovascular system

Wikipedia : 74 Fibroadenomas are benign breast tumours characterized by an admixture of stromal and epithelial tissue.... more...

Related Diseases for Breast Fibroadenoma

Diseases in the Breast Fibroadenoma family:

Multiple Fibroadenomas of the Breast

Diseases related to Breast Fibroadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 332)
# Related Disease Score Top Affiliating Genes
1 papilloma 31.3 RASSF1 KRT8 KRT14 ESR1
2 carcinosarcoma 31.0 PGR MME ERBB2
3 pregnancy adenoma 31.0 PGR KRT14
4 pleomorphic lipoma 30.9 PGR HMGA2
5 breast disease 30.9 PGR MKI67 ESR1 ERBB2 CYP19A1 CTSD
6 lobular neoplasia 30.7 PGR ESR1 ERBB2 CT45A10
7 gynecomastia 30.7 PGR ESR1 ERBB2 CYP19A1 AR
8 hypertrophy of breast 30.6 PGR ESR1 ERBB2 CYP19A1
9 benign breast phyllodes tumor 30.6 PGR MME MKI67 MED12 LCOR
10 subareolar duct papillomatosis 30.6 MME KRT8
11 papillary carcinoma 30.6 PGR NME1 ESR1 ERBB2
12 microglandular adenosis 30.6 PGR ESR1 ERBB2
13 tubular adenocarcinoma 30.6 PGR MME ESR1 ERBB2
14 bilateral breast cancer 30.6 PGR ESR1 ERBB2
15 intraductal papilloma 30.6 PGR KRT14 ESR1 ERBB2
16 hidrocystoma 30.5 KRT8 KRT15
17 myoma 30.4 PGR MME MED12 HMGA2 ESR1 CYP19A1
18 leiomyosarcoma 30.4 PGR MED12 HMGA2 ESR1
19 breast malignant phyllodes tumor 30.4 PGR MME MED12 ESR1 ERBB2
20 breast sarcoma 30.4 PGR MME ESR1 ERBB2
21 endometrial stromal sarcoma 30.4 PGR MME ESR1 CYP19A1
22 prostatic hypertrophy 30.3 PGR ESR1 CYP19A1 AR
23 in situ carcinoma 30.3 PGR KRT8 KRT14 ESR1 ERBB2 CYP19A1
24 leiomyoma 30.2 PGR MME MKI67 MED12 HMGA2 ESR1
25 breast osteosarcoma 30.2 PGR MME KRT8 ESR1 ERBB2
26 leiomyoma, uterine 30.2 PGR MED12 HMGA2 HMGA1 ESR1 CYP19A1
27 adenosquamous carcinoma 30.2 PGR KRT8 CTSD AR
28 ovarian disease 30.1 PGR ESR1 ERBB2 CYP19A1 AR
29 apocrine adenocarcinoma 30.1 PGR KRT14 ESR1 ERBB2 AR
30 adenomyosis 30.0 TIMP2 PGR MME ESR1 CYP19A1
31 ductal carcinoma in situ 29.8 RASSF1 PGR MME MKI67 KRT8 KRT14
32 breast carcinoma in situ 29.8 PGR KRT8 KRT14 ESR1 ERBB2 CYP19A1
33 breast ductal carcinoma 29.1 TIMP2 PGR NME1 MKI67 KRT8 KRT14
34 ovarian cancer 28.6 TIMP2 RASSF1 PGR NME1 HMGA2 HIF1A
35 breast cancer 28.5 TIMP2 RASSF1 PGR NME1 MKI67 KRT8
36 obsolete: multiple fibroadenoma of the breast 12.2
37 multiple fibroadenomas of the breast 11.7
38 breast pericanalicular fibroadenoma 11.4
39 breast intracanalicular fibroadenoma 11.4
40 breast giant fibroadenoma 11.4
41 breast fibroadenosis 11.4
42 scirrhous adenocarcinoma 10.6 PGR ERBB2
43 bartholin's gland adenoid cystic carcinoma 10.6 PGR ESR1
44 chronic tympanitis 10.6 PGR ESR1
45 bartholin's gland adenoma 10.6 PGR ESR1
46 granulomatous endometritis 10.6 PGR ESR1
47 bartholin's gland benign neoplasm 10.6 PGR ESR1
48 vestibular gland benign neoplasm 10.6 PGR ESR1
49 diffuse peritoneal leiomyomatosis 10.6 PGR MED12
50 lipid-rich breast carcinoma 10.6 PGR ERBB2

Graphical network of the top 20 diseases related to Breast Fibroadenoma:



Diseases related to Breast Fibroadenoma

Symptoms & Phenotypes for Breast Fibroadenoma

MGI Mouse Phenotypes related to Breast Fibroadenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.2 AR CTSD CYP19A1 ERBB2 ESR1 HIF1A
2 cardiovascular system MP:0005385 10.18 AR CYP19A1 ERBB2 ESR1 HIF1A KRT8
3 homeostasis/metabolism MP:0005376 10.18 AR CTSD CYP19A1 ERBB2 ESR1 HIF1A
4 digestive/alimentary MP:0005381 10.13 AR CTSD CYP19A1 ERBB2 ESR1 HIF1A
5 endocrine/exocrine gland MP:0005379 10.1 AR CTSD CYP19A1 ERBB2 ESR1 HIF1A
6 immune system MP:0005387 10.06 AR CTSD CYP19A1 ESR1 HIF1A KRT14
7 integument MP:0010771 9.96 AR CTSD CYP19A1 ERBB2 ESR1 HIF1A
8 liver/biliary system MP:0005370 9.76 AR CYP19A1 ESR1 HIF1A KRT8 MME
9 neoplasm MP:0002006 9.56 AR ERBB2 ESR1 HIF1A KRT14 NME1
10 normal MP:0002873 9.32 AR CYP19A1 ERBB2 ESR1 HIF1A MED12

Drugs & Therapeutics for Breast Fibroadenoma

Drugs for Breast Fibroadenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamoxifen Approved Phase 4 10540-29-1 2733526
2 Estrogens Phase 4
3 Hormone Antagonists Phase 4
4 Selective Estrogen Receptor Modulators Phase 4
5 Antineoplastic Agents, Hormonal Phase 4
6 Estrogen Receptor Antagonists Phase 4
7 Analgesics Phase 4
8 Estrogen Antagonists Phase 4
9 Estrogen Receptor Modulators Phase 4
10 Hormones Phase 4
11 Hypolipidemic Agents Phase 4
12 Anti-Inflammatory Agents, Non-Steroidal Phase 4
13 Analgesics, Non-Narcotic Phase 4
14 Anti-Inflammatory Agents Phase 4
15 Dermatologic Agents Phase 4
16 Lipid Regulating Agents Phase 4
17 Antirheumatic Agents Phase 4
18 Evening Primrose Phase 4
19 Antimetabolites Phase 4
20
Evening primrose oil Investigational, Nutraceutical Phase 4 308064-97-3
21
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
22
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
23
Iodine Approved, Investigational Phase 2 7553-56-2 807
24
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
25 BB 1101 Phase 2
26 cadexomer iodine Phase 2

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 A Single Blinded Randomized Controlled Trial of the Comparative Effects of Tamoxifen and Evening Primrose Oil in Premenopausal Non-high Risk Patients With Benign Breast Disease With Respect to the Estrogen Receptor Status. Completed NCT00999921 Phase 4 Tamoxifen;Evening Primrose Oil
2 Phase 3 Study of MR Guided Focused Ultrasound Surgery in the Treatment of Breast Fibroadenomas Terminated NCT00147108 Phase 3
3 Analgesic Efficacy of Pulsed Radiofrequency in Non-cyclic Mastalgia Completed NCT03715413 Phase 2 Tamoxifen
4 High Intensity Focused Ultrasound (HIFU) to Treat Breast Fibroadenoma: a Feasibility Study. A Multicentric, Open, Uncontrolled Study Completed NCT01422629
5 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU) Completed NCT03022695
6 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU) Completed NCT02011919
7 High Intensity Focused Ultrasound for the Treatment of Fibroadenomata (HIFU-F) Completed NCT02139683
8 Evaluation of Safety and Feasibility of the ICE-SENSE™, a Cryotherapy Device for Office-based Ultrasound-guided Treatment of Breast Fibroadenoma Completed NCT00910312
9 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU): A Feasibility Study Completed NCT02078011
10 A Pilot Study Evaluation of the Efficacy of SonoVue to Detect and Characterise Breast Lesions Completed NCT00243698 SonoVue (sulphur hexafluoride microbubbles)
11 Post-CE Marking Continuing Evaluation of Multi-Static Microwave Imaging of the Female Breast in Controlled Trial to Identify Optimum Use of the MARIA Platform in the Clinical Workflow Completed NCT02493595
12 Infrared Imaging (Breast Scan IR) for Early Breast Cancer Detection Completed NCT00195026
13 Treatment of Breast Fibroadenoma Targeted Tissue With High Intensity Focused Ultrasound (HIFU) Recruiting NCT03044054
14 Treatment of Breast Fibroadenoma With FastScan High Intensity Focused Ultrasound (HIFU) Recruiting NCT02488655
15 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU) vS Surgery: A Prospective Randomized Study Recruiting NCT03742401
16 American Breast Laser Ablation Therapy Evaluation (ABLATE): Monitoring the Long Term Safety and Efficacy of Novilase™ Breast Interstitial Laser Therapy in Real World Application Recruiting NCT00807924
17 Treatment of Breast Fibroadenoma With High Intensity Focused Ultrasound (HIFU): a Feasibility Study Active, not recruiting NCT01331954
18 A Prospective Multi-center Case Collection Study of Breast Imaging Examinations From Women With Non-suspicious Breast Masses to Correlate the Calculated Mass Doubling Time Using Quantitative Transmission Ultrasound (QT Ultrasound) With Mass Histology. Active, not recruiting NCT03470051
19 Efficacy, Safety, Cosmesis and Patient Satisfaction With Vacuum-Assisted Percutaneous Excision (VAPE) Compared With Standard Surgical Excision (X) of Non-malignant, Borderline or High-risk Breast Lesions: A Randomized Controlled Trial Not yet recruiting NCT03868475

Search NIH Clinical Center for Breast Fibroadenoma

Cochrane evidence based reviews: fibroadenoma

Genetic Tests for Breast Fibroadenoma

Anatomical Context for Breast Fibroadenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Breast Fibroadenoma:

19
Breast

MalaCards organs/tissues related to Breast Fibroadenoma:

40
Breast, Prostate, Thyroid, Lung, Ovary, Smooth Muscle, Lymph Node

Publications for Breast Fibroadenoma

Articles related to Breast Fibroadenoma:

(show top 50) (show all 2453)
# Title Authors PMID Year
1
Progesterone receptors A and B and estrogen receptor alpha expression in normal breast tissue and fibroadenomas. 54 61
19367380 2009
2
Analysis of human mammary fibroadenoma by Ki-67 index in the follicular and luteal phases of menstrual cycle. 54 61
19317807 2009
3
Mean nuclear area and metallothionein expression in ductal breast tumors: correlation with estrogen receptor status. 54 61
18227734 2008
4
High prevalence of HER-2/neu overexpression in female breast cancer among an Iraqi population exposed to depleted uranium. 54 61
19008567 2008
5
Adenoma of anogenital mammary-like glands. 54 61
17845825 2007
6
Expression of nm23, MMP-2, TIMP-2 in breast neoplasm in Zhengzhou Center Hospital, China. 54 61
17642161 2007
7
[HIF-1alpha expression and relationship involving tumor cell proliferation and angiogenesis in human breast carcinoma]. 54 61
17294729 2007
8
Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast. 54 61
16554735 2006
9
A polymorphism at codon 133 of the tumor suppressor RASSF1A is associated with tumorous alteration of the breast. 54 61
15942659 2005
10
Expression of hypoxia-inducible factor (HIF-1alpha), VEGF-C and VEGF-D in non-invasive and invasive breast ductal carcinomas. 54 61
16080559 2005
11
Estrogen receptor-alpha, bcl-2 and c-myc gene expression in fibroadenomas and adjacent normal breast: association with nodule size, hormonal and reproductive features. 54 61
15763593 2005
12
Metaphase and interphase cytogenetics in fibroadenomas of the breast. 54 61
15646810 2004
13
Extracellular DNA in breast cancer: Cell-surface-bound, tumor-derived extracellular DNA in blood of patients with breast cancer and nonmalignant tumors. 54 61
15251963 2004
14
[Expression of tyrosine kinase Syk in breast cancer and their clinical significance]. 54 61
15062056 2004
15
[Hypermethylation of syk gene in promoter region is associated with oncogenesis, metastasis of breast carcinoma]. 54 61
15059510 2004
16
The effect of tamoxifen on PCNA expression in fibroadenomas. 54 61
12846865 2003
17
Naked nuclei revisited: p63 Immunoexpression. 54 61
12203858 2002
18
Proliferating activity in differential diagnosis of benign phyllodes tumor and cellular fibroadenomas: is it helpful? 54 61
11692149 2001
19
A comparison of the pattern of cathepsin-D expression in fibroadenoma, fibrocystic disease, preinvasive and invasive ductal breast carcinoma. 54 61
10503271 1999
20
The expression and localization of fibroblast growth factor-1 (FGF-1) and FGF receptor-1 (FGFR-1) in human breast cancer. 54 61
9756721 1998
21
Immunohistochemical study of TGF-alpha, TGF-beta1, EGFR, and IGF-1 expression in human breast carcinoma. 54 61
9346175 1997
22
Analysis of polypeptide expression in benign and malignant human breast lesions. 54 61
9150945 1997
23
Mammary fibroadenoma and some phyllodes tumour stroma are composed of CD34+ fibroblasts and factor XIIIa+ dendrophages. 54 61
8951485 1996
24
Analysis of polypeptide expression in benign and malignant human breast lesions: down-regulation of cytokeratins. 54 61
8932346 1996
25
Production of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human breast carcinomas. 54 61
8766524 1996
26
A fibroadenoma with a t(4;12) (q27;q15) affecting the HMGI-C gene, a member of the high mobility group protein gene family. 54 61
8739083 1996
27
Progression of fibroadenoma to phyllodes tumor demonstrated by clonal analysis. 54 61
8625047 1995
28
Reduction of telomeric length and c-erbB-2 gene amplification in human breast cancer, fibroadenoma, and gynecomastia. Relationship to histologic grade and clinical parameters. 54 61
7911069 1994
29
Glial fibrillary acidic protein immunoreactivity in normal and diseased human breast. 54 61
1708927 1991
30
Antigenic profile of mammary fibroadenoma and cystosarcoma phyllodes. A study using antibodies to estrogen- and progesterone receptors and to a panel of cell surface molecules. 54 61
2174150 1990
31
Surgical management of giant juvenile fibroadenoma with skin reducing tumor resection and immediate breast reconstruction: A single-center experience. 61
31907948 2020
32
Primary Osteosarcoma of the Breast: Pathophysiology and Imaging Review. 61
30655112 2020
33
A Pre-operative Score to Discriminate Fibroepithelial Lesions of the Breast: Phyllode Tumor or Fibroadenoma? 61
32014959 2020
34
Fibroepithelial Lesions (FELs) of the Breast: Is Routine Excision Always Necessary? 61
31974650 2020
35
Synovial sarcoma of the floor of the mouth: a rare case report. 61
31906928 2020
36
Cutaneous spindle cell adenolipoma with eccrine and apocrine differentiation. 61
31329294 2020
37
Recurrent giant fibroadenomas with transformation to cystosarcoma phyllodes in a 17-year-old girl: a rare case report from Syria. 61
31862014 2019
38
Imaging findings of ductal carcinoma in situ arising within fibroadenoma. 61
31837072 2019
39
An 18-year-old woman with pulmonary nodules found to have cytotoxic T-lymphocyte-associated antigen 4 deficiency. 61
31818888 2019
40
Expression of matrix metalloproteinase 2 and 9 in breast cancer and breast fibroadenoma: a randomized, double-blind study. 61
31839881 2019
41
Accuracy and clinical implications of pre-operative breast core needle biopsy diagnoses of fibroepithelial neoplasms and sarcomatoid carcinomas. 61
31332664 2019
42
Low-dose imaging technique (LITE) MRI: initial experience in breast imaging. 61
31271535 2019
43
Pediatric Breast Fibroadenomas: A Systematic Review and Algorithm for Treatment. 61
30628932 2019
44
Solitary Bone Cyst Like Areas in Myositis Ossificans: A Breast Mass in a Child. 61
31757181 2019
45
Evaluating the glycophenotype on breast cancer tissues with quantum dots-Cramoll lectin conjugates. 61
31306700 2019
46
Imaging of Lactating Adenoma: Differential Diagnosis of Solid Mass Lesion in a Lactating Woman. 61
31867197 2019
47
miR-188-5p suppresses cellular proliferation and migration via IL6ST: A potential noninvasive diagnostic biomarker for breast cancer. 61
31650530 2019
48
Symptomatic Fibroadenoma Resolves Status Post Cryoablation. 61
31575100 2019
49
Medulla loss of scalp hair in breast cancer patients determined by near-infrared microscopy. 61
31512440 2019
50
Enlarging biopsy-proven fibroadenoma: Is surgical excision necessary? 61
31103907 2019

Variations for Breast Fibroadenoma

Expression for Breast Fibroadenoma

Search GEO for disease gene expression data for Breast Fibroadenoma.

Pathways for Breast Fibroadenoma

GO Terms for Breast Fibroadenoma

Cellular components related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.83 RASSF1 PGR NME1 MKI67 MED12 LCOR
2 intermediate filament GO:0005882 9.46 NME1 KRT8 KRT15 KRT14
3 senescence-associated heterochromatin focus GO:0035985 8.62 HMGA2 HMGA1

Biological processes related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10 PGR MED12 HMGA2 HMGA1 HIF1A ESR1
2 regulation of transcription by RNA polymerase II GO:0006357 9.95 MED12 LCOR HIF1A ESR1 ERBB2 AR
3 negative regulation of gene expression GO:0010629 9.8 PGR NME1 HIF1A ESR1
4 positive regulation of transcription, DNA-templated GO:0045893 9.8 MED12 HMGA2 HMGA1 HIF1A ESR1 AR
5 transcription initiation from RNA polymerase II promoter GO:0006367 9.67 PGR MED12 ESR1 AR
6 steroid hormone mediated signaling pathway GO:0043401 9.58 PGR ESR1 AR
7 prostate gland growth GO:0060736 9.43 CYP19A1 AR
8 mammary gland development GO:0030879 9.43 PGR NME1 CYP19A1
9 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.16 PGR AR
10 senescence-associated heterochromatin focus assembly GO:0035986 8.96 HMGA2 HMGA1
11 oncogene-induced cell senescence GO:0090402 8.62 HMGA2 HMGA1

Molecular functions related to Breast Fibroadenoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.28 TIMP2 RASSF1 PGR NME1 MME MKI67
2 zinc ion binding GO:0008270 9.93 TIMP2 RASSF1 PGR MME ESR1 AR
3 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.8 PGR HMGA2 HIF1A ESR1 AR
4 beta-catenin binding GO:0008013 9.67 MED12 ESR1 AR
5 ATPase binding GO:0051117 9.65 PGR ESR1 AR
6 steroid hormone receptor activity GO:0003707 9.54 PGR ESR1 AR
7 DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0003906 9.51 HMGA2 HMGA1
8 AT DNA binding GO:0003680 9.43 HMGA2 HMGA1
9 nuclear receptor activity GO:0004879 9.43 PGR ESR1 AR
10 enzyme binding GO:0019899 9.43 PGR NME1 HMGA1 HIF1A ESR1 AR
11 steroid binding GO:0005496 9.33 PGR ESR1 AR
12 transcription factor binding GO:0008134 9.1 MED12 HMGA2 HMGA1 HIF1A ESR1 AR

Sources for Breast Fibroadenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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