MCID: BRS008
MIFTS: 22

Breast Giant Fibroadenoma

Categories: Cancer diseases

Aliases & Classifications for Breast Giant Fibroadenoma

MalaCards integrated aliases for Breast Giant Fibroadenoma:

Name: Breast Giant Fibroadenoma 12 15
Giant Fibroadenoma of Breast 12 70
Giant Fibroadenoma 12 70

Classifications:



External Ids:

Disease Ontology 12 DOID:7223
NCIt 50 C4273
SNOMED-CT 67 254846003
UMLS 70 C0334500 C0346157

Summaries for Breast Giant Fibroadenoma

Disease Ontology : 12 A breast fibroadenoma that is larger than 5 cm.

MalaCards based summary : Breast Giant Fibroadenoma, also known as giant fibroadenoma of breast, is related to benign breast phyllodes tumor and breast disease. An important gene associated with Breast Giant Fibroadenoma is BMP8A (Bone Morphogenetic Protein 8a), and among its related pathways/superpathways are Hippo signaling pathway and Transcription_P53 signaling pathway. Affiliated tissues include breast, heart and tongue, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Breast Giant Fibroadenoma

Diseases related to Breast Giant Fibroadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 benign breast phyllodes tumor 10.4
2 breast disease 10.2
3 breast fibroadenoma 10.2
4 ptosis 10.1
5 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.9
6 hypertrophy of breast 9.9
7 mastitis 9.9
8 breast pericanalicular fibroadenoma 9.9
9 adenofibroma 9.9
10 carcinosarcoma 9.9
11 gigantomastia 9.9
12 tympanic membrane disease 9.6 BMP8B BMP8A

Graphical network of the top 20 diseases related to Breast Giant Fibroadenoma:



Diseases related to Breast Giant Fibroadenoma

Symptoms & Phenotypes for Breast Giant Fibroadenoma

GenomeRNAi Phenotypes related to Breast Giant Fibroadenoma according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.64 BMP8A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.64 MCM4
3 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.64 MCM4
4 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.64 BMP8A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.64 MCM4 PARVA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-181 9.64 MCM4
7 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.64 MCM4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-200 9.64 BMP8A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.64 MCM4
10 Increased shRNA abundance (Z-score > 2) GR00366-A-27 9.64 BMP8A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.64 MCM4 PARVA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-5 9.64 MCM4
13 Increased shRNA abundance (Z-score > 2) GR00366-A-55 9.64 BMP8A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.64 MCM4
15 Increased shRNA abundance (Z-score > 2) GR00366-A-66 9.64 MCM4
16 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.64 BMP8A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.64 MCM4 PARVA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.64 BMP8A

Drugs & Therapeutics for Breast Giant Fibroadenoma

Search Clinical Trials , NIH Clinical Center for Breast Giant Fibroadenoma

Genetic Tests for Breast Giant Fibroadenoma

Anatomical Context for Breast Giant Fibroadenoma

MalaCards organs/tissues related to Breast Giant Fibroadenoma:

40
Breast, Heart, Tongue

Publications for Breast Giant Fibroadenoma

Articles related to Breast Giant Fibroadenoma:

# Title Authors PMID Year
1
Giant fibroma of breast in an adolescent female by inverted "T" incision: A case report and literature review. 61
32386049 2020
2
Surgical excision of the breast giant fibroadenoma under regional anesthesia by Pecs II and internal intercostal plane block: a case report and brief technical description: a case report. 61
28184271 2017
3
Giant fibroadenoma of breast in an adolescent girl. 61
23071885 2012
4
An extraordinary breast giant fibroadenoma (cystosarcoma phyllodes) in a female adolescent. 61
6097413 1984

Variations for Breast Giant Fibroadenoma

Expression for Breast Giant Fibroadenoma

Search GEO for disease gene expression data for Breast Giant Fibroadenoma.

Pathways for Breast Giant Fibroadenoma

Pathways related to Breast Giant Fibroadenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.35 BMP8B BMP8A
2 10.99 BMP8B BMP8A
3 10.93 BMP8B BMP8A
4 9.7 FGF22 BMP8B BMP8A

GO Terms for Breast Giant Fibroadenoma

Cellular components related to Breast Giant Fibroadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 THBS4 FGF22 BMP8B BMP8A

Biological processes related to Breast Giant Fibroadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.32 BMP8B BMP8A
2 BMP signaling pathway GO:0030509 9.26 BMP8B BMP8A
3 cartilage development GO:0051216 9.16 BMP8B BMP8A
4 SMAD protein signal transduction GO:0060395 8.96 BMP8B BMP8A
5 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 8.62 BMP8B BMP8A

Molecular functions related to Breast Giant Fibroadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 BMP receptor binding GO:0070700 8.96 BMP8B BMP8A
2 growth factor activity GO:0008083 8.92 THBS4 FGF22 BMP8B BMP8A

Sources for Breast Giant Fibroadenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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