Breast Giant Fibroadenoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Breast Giant Fibroadenoma

MalaCards integrated aliases for Breast Giant Fibroadenoma:

Name: Breast Giant Fibroadenoma ¹² ¹⁵

Giant Fibroadenoma of Breast ¹² ⁷⁰

Giant Fibroadenoma ¹² ⁷⁰

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7223

NCIt ⁵⁰ C4273

SNOMED-CT ⁶⁷ 254846003

UMLS ⁷⁰ C0334500 C0346157

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Summaries for Breast Giant Fibroadenoma

Disease Ontology : ¹² A breast fibroadenoma that is larger than 5 cm.

MalaCards based summary : Breast Giant Fibroadenoma, also known as giant fibroadenoma of breast, is related to benign breast phyllodes tumor and breast disease. An important gene associated with Breast Giant Fibroadenoma is BMP8A (Bone Morphogenetic Protein 8a), and among its related pathways/superpathways are Hippo signaling pathway and Transcription_P53 signaling pathway. Affiliated tissues include breast, heart and tongue, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Breast Giant Fibroadenoma

Diseases related to Breast Giant Fibroadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)

#	Related Disease	Score	Top Affiliating Genes
1	benign breast phyllodes tumor	10.4
2	breast disease	10.2
3	breast fibroadenoma	10.2
4	ptosis	10.1
5	congenital heart defects, hamartomas of tongue, and polysyndactyly	9.9
6	hypertrophy of breast	9.9
7	mastitis	9.9
8	breast pericanalicular fibroadenoma	9.9
9	adenofibroma	9.9
10	carcinosarcoma	9.9
11	gigantomastia	9.9
12	tympanic membrane disease	9.6	BMP8B BMP8A

Graphical network of the top 20 diseases related to Breast Giant Fibroadenoma:

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Symptoms & Phenotypes for Breast Giant Fibroadenoma

GenomeRNAi Phenotypes related to Breast Giant Fibroadenoma according to GeneCards Suite gene sharing:

²⁶ (show all 18)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-126	9.64	BMP8A
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-128	9.64	MCM4
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-168	9.64	MCM4
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-178	9.64	BMP8A
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-180	9.64	MCM4 PARVA
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-181	9.64	MCM4
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-192	9.64	MCM4
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-200	9.64	BMP8A
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-21	9.64	MCM4
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-27	9.64	BMP8A
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-46	9.64	MCM4 PARVA
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-5	9.64	MCM4
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-55	9.64	BMP8A
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.64	MCM4
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-66	9.64	MCM4
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	9.64	BMP8A
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-76	9.64	MCM4 PARVA
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-88	9.64	BMP8A

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Drugs & Therapeutics for Breast Giant Fibroadenoma

Search Clinical Trials , NIH Clinical Center for Breast Giant Fibroadenoma

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Genetic Tests for Breast Giant Fibroadenoma

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Anatomical Context for Breast Giant Fibroadenoma

MalaCards organs/tissues related to Breast Giant Fibroadenoma:

⁴⁰

Breast, Heart, Tongue

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Publications for Breast Giant Fibroadenoma

Articles related to Breast Giant Fibroadenoma:

#	Title	Authors	PMID	Year
1	Giant fibroma of breast in an adolescent female by inverted "T" incision: A case report and literature review. ⁶¹	Tian J...Chen Q	32386049	2020
2	Surgical excision of the breast giant fibroadenoma under regional anesthesia by Pecs II and internal intercostal plane block: a case report and brief technical description: a case report. ⁶¹	Kim H...Kim I	28184271	2017
3	Giant fibroadenoma of breast in an adolescent girl. ⁶¹	Thuruthiyath N...Marla N	23071885	2012
4	An extraordinary breast giant fibroadenoma (cystosarcoma phyllodes) in a female adolescent. ⁶¹	Dong HJ...Ke RL	6097413	1984

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Genes for Breast Giant Fibroadenoma

Genes related to Breast Giant Fibroadenoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	BMP8A	Bone Morphogenetic Protein 8a	Protein Coding	6.57	DISEASES inferred ¹⁵
2	FGF22	Fibroblast Growth Factor 22	Protein Coding	6.3	DISEASES inferred ¹⁵
3	PARVA	Parvin Alpha	Protein Coding	6.07	DISEASES inferred ¹⁵
4	BMP8B	Bone Morphogenetic Protein 8b	Protein Coding	5.59	DISEASES inferred ¹⁵
5	THBS4	Thrombospondin 4	Protein Coding	5.57	DISEASES inferred ¹⁵
6	MCM4	Minichromosome Maintenance Complex Component 4	Protein Coding	5.38	DISEASES inferred ¹⁵

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Variations for Breast Giant Fibroadenoma

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Expression for Breast Giant Fibroadenoma

Search GEO for disease gene expression data for Breast Giant Fibroadenoma.

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Pathways for Breast Giant Fibroadenoma

Pathways related to Breast Giant Fibroadenoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Hippo signaling pathway ³⁶	11.35	BMP8B BMP8A
2	Transcription_P53 signaling pathway ²³	10.99	BMP8B BMP8A
3	TGF-beta signaling pathway (KEGG) ³⁶	10.93	BMP8B BMP8A
4	G-protein signaling_Rap2B regulation pathway ²³	9.7	FGF22 BMP8B BMP8A

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GO Terms for Breast Giant Fibroadenoma

Cellular components related to Breast Giant Fibroadenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	8.92	THBS4 FGF22 BMP8B BMP8A

Biological processes related to Breast Giant Fibroadenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ossification	GO:0001503	9.32	BMP8B BMP8A
2	BMP signaling pathway	GO:0030509	9.26	BMP8B BMP8A
3	cartilage development	GO:0051216	9.16	BMP8B BMP8A
4	SMAD protein signal transduction	GO:0060395	8.96	BMP8B BMP8A
5	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:0010862	8.62	BMP8B BMP8A

Molecular functions related to Breast Giant Fibroadenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	BMP receptor binding	GO:0070700	8.96	BMP8B BMP8A
2	growth factor activity	GO:0008083	8.92	THBS4 FGF22 BMP8B BMP8A

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Sources for Breast Giant Fibroadenoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia