Breast Giant Fibroadenoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Breast Giant Fibroadenoma

MalaCards integrated aliases for Breast Giant Fibroadenoma:

Name: Breast Giant Fibroadenoma ¹² ¹⁵

Giant Fibroadenoma of Breast ¹² ⁷³

Giant Fibroadenoma ¹² ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7223

NCIt ⁵⁰ C4273

UMLS ⁷³ C0346157 C0334500

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Summaries for Breast Giant Fibroadenoma

Disease Ontology : ¹² A breast fibroadenoma that is larger than 5 cm.

MalaCards based summary : Breast Giant Fibroadenoma, also known as giant fibroadenoma of breast, is related to breast fibroadenoma and heart sarcoma. An important gene associated with Breast Giant Fibroadenoma is BCS1L (BCS1 Homolog, Ubiquinol-Cytochrome C Reductase Complex Chaperone), and among its related pathways/superpathways are Pathways in cancer and Senescence and Autophagy in Cancer. Affiliated tissues include brain, bone and colon, and related phenotypes are homeostasis/metabolism and mortality/aging

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Related Diseases for Breast Giant Fibroadenoma

Diseases related to Breast Giant Fibroadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)

#	Related Disease	Score	Top Affiliating Genes
1	breast fibroadenoma	10.3
2	heart sarcoma	10.2	GFPT1 WT1
3	tumor predisposition syndrome	10.1	BRCA2 PMS2
4	peritoneum cancer	10.1	BRCA2 WT1
5	lynch syndrome i	10.1	BRCA2 PMS2
6	spinal cord astrocytoma	10.1	CD44 MGMT
7	sebaceous adenoma	10.1	ESR1 PMS2
8	peritoneal benign neoplasm	10.1	ESR1 WT1
9	diffuse peritoneal leiomyomatosis	10.1	ESR1 WT1
10	dysgerminoma of ovary	10.1	BRCA2 WT1
11	mucinoses	10.1	CD44 IFNG
12	female reproductive endometrioid cancer	10.0	ESR1 WT1
13	synchronous bilateral breast carcinoma	10.0	BRCA2 ESR1
14	breast cancer	10.0
15	breast reconstruction	10.0
16	primary peritoneal carcinoma	10.0	BRCA2 IFNG
17	fallopian tube squamous cell carcinoma	10.0	CDKN2A WT1
18	anaplastic oligodendroglioma	10.0	CDKN2A MGMT
19	melanomatosis	10.0	CDKN2A WT1
20	fallopian tube carcinoma	10.0	BRCA2 ESR1
21	sarcomatoid mesothelioma	10.0	CDKN2A WT1
22	dysplastic nevus syndrome	10.0	BRCA2 CDKN2A
23	uterine sarcoma	10.0	ESR1 WT1
24	pleural cancer	9.9	CDKN2A WT1
25	gastric adenosquamous carcinoma	9.9	CD44 CDKN2A
26	malignant ovarian surface epithelial-stromal neoplasm	9.9	BRCA2 ESR1 WT1
27	ovary epithelial cancer	9.9	BRCA2 ESR1 WT1
28	colonic disease	9.9	CD44 ESR1 PMS2
29	bartholin's gland benign neoplasm	9.9	CDKN2A ESR1
30	endometrial squamous cell carcinoma	9.9	CDKN2A ESR1
31	endometrial mucinous adenocarcinoma	9.9	CDKN2A ESR1
32	adenoid basal cell carcinoma	9.9	CDKN2A ESR1
33	endocervical carcinoma	9.9	CDKN2A ESR1
34	ovarian cancer 1	9.9	BRCA2 WT1
35	benign breast phyllodes tumor	9.9
36	hypertrichosis	9.9
37	brain cancer	9.9	BRCA2 CD44 MGMT PMS2
38	breast carcinoma in situ	9.9	BRCA2 ESR1
39	central nervous system lymphoma	9.9	CDKN2A MGMT
40	gastrointestinal system cancer	9.8	CD44 CDKN2A PMS2
41	supratentorial cancer	9.8	CD44 CDKN2A MGMT
42	cerebrum cancer	9.8	CD44 CDKN2A MGMT
43	wilms tumor 1	9.8	BRCA2 ESR1 WT1
44	uterine anomalies	9.8	CDKN2A ESR1 PMS2
45	peritoneal mesothelioma	9.8	CDKN2A ESR1 WT1
46	glioblastoma multiforme	9.8	CD44 CDKN2A MGMT
47	in situ carcinoma	9.8	CDKN2A ESR1
48	gastrointestinal system disease	9.8	CD44 CDKN2A IFNG
49	glycogen-rich clear cell breast carcinoma	9.8	BRCA2 CDKN2A ESR1
50	pre-malignant neoplasm	9.8	BRCA2 CDKN2A ESR1

Graphical network of the top 20 diseases related to Breast Giant Fibroadenoma:

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Symptoms & Phenotypes for Breast Giant Fibroadenoma

MGI Mouse Phenotypes related to Breast Giant Fibroadenoma:

⁴⁶ (show all 17)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.24	BCS1L BRCA2 CD44 CDKN2A ESR1 IFNG
2	mortality/aging	MP:0010768	10.21	BCS1L BRCA2 CD44 CDKN2A ESR1 GFPT1
3	endocrine/exocrine gland	MP:0005379	10.19	BCS1L BRCA2 CD44 CDKN2A ESR1 IFNG
4	cellular	MP:0005384	10.17	BCS1L BRCA2 CD44 CDKN2A ESR1 IFNG
5	growth/size/body region	MP:0005378	10.13	BCS1L BRCA2 CD44 CDKN2A ESR1 IFNG
6	hematopoietic system	MP:0005397	10.11	BRCA2 CD44 CDKN2A ESR1 GFPT1 IFNG
7	immune system	MP:0005387	10.08	BRCA2 CD44 CDKN2A ESR1 GFPT1 IFNG
8	liver/biliary system	MP:0005370	10.06	BCS1L CD44 CDKN2A ESR1 IFNG PMS2
9	digestive/alimentary	MP:0005381	10.03	BRCA2 CD44 CDKN2A ESR1 IFNG PMS2
10	embryo	MP:0005380	10.02	BRCA2 CDKN2A ESR1 IFNG PARVA WT1
11	neoplasm	MP:0002006	9.97	BRCA2 CD44 CDKN2A ESR1 IFNG MGMT
12	muscle	MP:0005369	9.88	CD44 CDKN2A ESR1 IFNG PARVA WT1
13	normal	MP:0002873	9.73	BRCA2 CD44 ESR1 IFNG UROD WT1
14	no phenotypic analysis	MP:0003012	9.72	CDKN2A ESR1 IFNG MGMT WT1
15	renal/urinary system	MP:0005367	9.63	BCS1L CD44 ESR1 IFNG PARVA WT1
16	reproductive system	MP:0005389	9.56	BCS1L BRCA2 CD44 CDKN2A ESR1 IFNG
17	respiratory system	MP:0005388	9.1	CD44 CDKN2A ESR1 IFNG MGMT WT1

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Drugs & Therapeutics for Breast Giant Fibroadenoma

Search Clinical Trials , NIH Clinical Center for Breast Giant Fibroadenoma

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Genetic Tests for Breast Giant Fibroadenoma

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Anatomical Context for Breast Giant Fibroadenoma

MalaCards organs/tissues related to Breast Giant Fibroadenoma:

⁴¹

Brain, Bone, Colon, Heart, Ovary, Spinal Cord

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Publications for Breast Giant Fibroadenoma

Articles related to Breast Giant Fibroadenoma:

#	Title	Authors	Year
1	Surgical excision of the breast giant fibroadenoma under regional anesthesia by Pecs II and internal intercostal plane block: a case report and brief technical description: a case report. ( 28184271 )	Kim H...Kim I	2017
2	Giant fibroadenoma of breast in an adolescent girl. ( 23071885 )	Thuruthiyath N...Marla N	2012
3	An extraordinary breast giant fibroadenoma (cystosarcoma phyllodes) in a female adolescent. ( 6097413 )	Dong HJ...Ke RL	1984

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Genes for Breast Giant Fibroadenoma

Genes related to Breast Giant Fibroadenoma (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	BCS1L	BCS1 Homolog, Ubiquinol-Cytochrome C Reductase Complex Chaperone	Protein Coding	15.15	DISEASES inferred ¹⁵
2	GFPT1	Glutamine--Fructose-6-Phosphate Transaminase 1	Protein Coding	15.09	DISEASES inferred ¹⁵
3	UROD	Uroporphyrinogen Decarboxylase	Protein Coding	14.74	DISEASES inferred ¹⁵
4	PMS2	PMS1 Homolog 2, Mismatch Repair System Component	Protein Coding	14.3	DISEASES inferred ¹⁵
5	MGMT	O-6-Methylguanine-DNA Methyltransferase	Protein Coding	14.09	DISEASES inferred ¹⁵
6	WT1	Wilms Tumor 1	Protein Coding	13.73	DISEASES inferred ¹⁵
7	BRCA2	BRCA2, DNA Repair Associated	Protein Coding	13.46	DISEASES inferred ¹⁵
8	CD44	CD44 Molecule (Indian Blood Group)	Protein Coding	13.4	DISEASES inferred ¹⁵
9	IFNG	Interferon Gamma	Protein Coding	13.31	DISEASES inferred ¹⁵
10	ESR1	Estrogen Receptor 1	Protein Coding	13.06	DISEASES inferred ¹⁵
11	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	13.05	DISEASES inferred ¹⁵
12	PARVA	Parvin Alpha	Protein Coding	5.98	DISEASES inferred ¹⁵

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Variations for Breast Giant Fibroadenoma

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Expression for Breast Giant Fibroadenoma

Search GEO for disease gene expression data for Breast Giant Fibroadenoma.

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Pathways for Breast Giant Fibroadenoma

Pathways related to Breast Giant Fibroadenoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Pathways in cancer ³⁷	12.18	BRCA2 CDKN2A ESR1 IFNG
2	Senescence and Autophagy in Cancer ¹	11.16	CD44 CDKN2A IFNG
3	FOXM1 transcription factor network ¹	10.82	BRCA2 ESR1
4	Regulation of Telomerase ¹	10.62	ESR1 IFNG WT1

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GO Terms for Breast Giant Fibroadenoma

Cellular components related to Breast Giant Fibroadenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleoplasm	GO:0005654	9.5	BRCA2 CDKN2A ESR1 MGMT PMS2 UROD
2	cytosol	GO:0005829	9.28	BRCA2 CD44 CDKN2A ESR1 GFPT1 PARVA

Biological processes related to Breast Giant Fibroadenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription, DNA-templated	GO:0045893	9.26	BRCA2 CDKN2A ESR1 WT1
2	positive regulation of smooth muscle cell apoptotic process	GO:0034393	8.62	CDKN2A IFNG

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Sources for Breast Giant Fibroadenoma

¹ BioSystems

² BitterDB

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⁷¹ TGDB

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⁷⁶ Wikipedia