MCID: BRS112
MIFTS: 35

Breast Implant-Associated Anaplastic Large Cell Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Breast Implant-Associated Anaplastic Large Cell Lymphoma

MalaCards integrated aliases for Breast Implant-Associated Anaplastic Large Cell Lymphoma:

Name: Breast Implant-Associated Anaplastic Large Cell Lymphoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0070333

Summaries for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Disease Ontology : 12 A periperal T-cell lymphoma characterized by development around textured-surface breast implants confined to the capsule.

MalaCards based summary : Breast Implant-Associated Anaplastic Large Cell Lymphoma is related to anaplastic large cell lymphoma and breast lymphoma. An important gene associated with Breast Implant-Associated Anaplastic Large Cell Lymphoma is JAK1 (Janus Kinase 1), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Cefazolin and Bacitracin have been mentioned in the context of this disorder. Affiliated tissues include breast, t cells and lymph node, and related phenotypes are hematopoietic system and endocrine/exocrine gland

Related Diseases for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Diseases related to Breast Implant-Associated Anaplastic Large Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 anaplastic large cell lymphoma 31.3 TNFRSF8 TIA1 STAT3 ALK
2 breast lymphoma 30.4 TNFRSF8 ALK
3 alk-negative anaplastic large cell lymphoma 29.9 STAT3 DUSP22 ALK
4 lymphoma 29.8 TP53 TNFRSF8 TIA1 STAT3 CCR6 ALK
5 lymphoma, non-hodgkin, familial 29.6 TP53 TNFRSF8 STAT3 CCR6 ALK
6 lymphoma, hodgkin, classic 29.4 TNFRSF8 TIA1 IL13 CCR6 ALK
7 peripheral t-cell lymphoma 28.3 TP53 TNFRSF8 TIA1 STAT3 DUSP22 DNMT3A
8 li-fraumeni syndrome 10.4
9 li-fraumeni syndrome 2 10.4
10 lymphoproliferative syndrome 10.4
11 t-cell non-hodgkin lymphoma 10.4
12 mixed lacrimal gland cancer 10.4 STAT3 JAK1
13 marginal zone b-cell lymphoma 10.3
14 bone squamous cell carcinoma 10.3 TP53 STAT3
15 liver benign neoplasm 10.2 TP53 STAT3
16 marek disease 10.2 TP53 TNFRSF8
17 intratubular embryonal carcinoma 10.2 TP53 TNFRSF8
18 papilledema 10.2 TP53 STAT3
19 low-grade astrocytoma 10.2 TP53 IL13
20 conventional fibrosarcoma 10.2 TP53 TNFRSF8
21 lymphosarcoma 10.2 TNFRSF8 DNMT3A
22 sarcomatoid transitional cell carcinoma 10.2 TP53 ALK
23 pfeiffer syndrome 10.2
24 alveolar soft part sarcoma 10.2
25 nodal marginal zone lymphoma 10.2
26 breast disease 10.2
27 hypereosinophilic syndrome 10.2
28 lymphoma aids related 10.2
29 hypoxia 10.2
30 rare tumor 10.2
31 parameningeal embryonal rhabdomyosarcoma 10.2 TP53 ALK
32 aggressive nk-cell leukemia 10.1 TIA1 STAT3
33 carbapenem allergy 10.1 IL13 ALK
34 mature teratoma 10.1 TP53 TNFRSF8
35 bone lymphoma 10.1 TNFRSF8 ALK
36 lethal midline granuloma 10.1 TNFRSF8 TIA1
37 pleural lipoma 10.1 TNFRSF8 ALK
38 adult lymphoma 10.1 TNFRSF8 ALK
39 hyper ige recurrent infection syndrome 1 10.1 STAT3 CCR6
40 composite lymphoma 10.1 TNFRSF8 TIA1
41 primary cutaneous anaplastic large cell lymphoma 10.0 TIA1 ALK
42 polycythemia vera 10.0 STAT3 JAK1 DNMT3A
43 esophagitis 10.0 TP53 STAT3 IL13
44 mikulicz disease 10.0 IL13 CCR6
45 nut allergy 10.0 IL13 CCR6
46 nasopharyngitis 10.0 JAK1 CCR6
47 cll/sll 10.0 TP53 CCR6
48 dacryoadenitis 10.0 IL13 CCR6
49 egg allergy 10.0 IL13 CCR6
50 systemic mastocytosis 10.0 TNFRSF8 STAT3 DNMT3A

Graphical network of the top 20 diseases related to Breast Implant-Associated Anaplastic Large Cell Lymphoma:



Diseases related to Breast Implant-Associated Anaplastic Large Cell Lymphoma

Symptoms & Phenotypes for Breast Implant-Associated Anaplastic Large Cell Lymphoma

MGI Mouse Phenotypes related to Breast Implant-Associated Anaplastic Large Cell Lymphoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 CCR6 DNMT3A DUSP22 IL13 JAK1 STAT3
2 endocrine/exocrine gland MP:0005379 9.87 ALK DNMT3A IL13 JAK1 STAT3 TNFRSF8
3 immune system MP:0005387 9.81 CCR6 DNMT3A DUSP22 IL13 JAK1 STAT3
4 respiratory system MP:0005388 9.43 ALK DUSP22 IL13 JAK1 STAT3 TP53
5 skeleton MP:0005390 9.17 ALK DNMT3A IL13 JAK1 STAT3 TIA1

Drugs & Therapeutics for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Drugs for Breast Implant-Associated Anaplastic Large Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefazolin Approved Phase 1 25953-19-9 656510 33255
2
Bacitracin Approved, Vet_approved Phase 1 1405-87-4 439542 10909430
3 Anti-Bacterial Agents Phase 1
4 Anti-Infective Agents, Local Phase 1
5 Gentamicins Phase 1
6 Antibiotics, Antitubercular Phase 1
7 Anti-Infective Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bacterial Biofilms in Reconstructive Breast Prostheses Following Mastectomy Completed NCT03213249 Phase 1 Cefazolin;Gentamicin;Bacitracin
2 Breast Implant-associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Registry Recruiting NCT04220970
3 Coordination of Rare Diseases at Sanford Recruiting NCT01793168

Search NIH Clinical Center for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Genetic Tests for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Anatomical Context for Breast Implant-Associated Anaplastic Large Cell Lymphoma

MalaCards organs/tissues related to Breast Implant-Associated Anaplastic Large Cell Lymphoma:

40
Breast, T Cells, Lymph Node, Bone Marrow, Bone, Skin, Nk Cells

Publications for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Articles related to Breast Implant-Associated Anaplastic Large Cell Lymphoma:

(show top 50) (show all 272)
# Title Authors PMID Year
1
Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Prospective Series of 52 Patients. 61
32568749 2020
2
The flow cytometric characteristics of breast implant-associated anaplastic large cell lymphoma. 61
32525554 2020
3
A Novel JAK1 Mutant Breast Implant-Associated Anaplastic Large Cell Lymphoma Patient-Derived Xenograft Fostering Pre-Clinical Discoveries. 61
32560455 2020
4
Additional Thoughts on Banning Textured Implants to Prevent Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL). 61
32538433 2020
5
Response to "Additional Thoughts on Banning Textured Implants to Prevent Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL)". 61
32539078 2020
6
Should Flow Cytometry Be Considered a First Line of Study in the Diagnosis of Breast Implant-Associated Anaplastic Large-Cell Lymphoma? 61
32552470 2020
7
Commentary on: Is Banning Texturized Implants to Prevent Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) a Rational Decision? A Meta-Analysis and Cost-Effectiveness Study. 61
32129816 2020
8
Commentary on: Is Banning Texturized Implants to Prevent Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) a Rational Decision? A Meta-Analysis and Cost-Effectiveness Study. 61
32129817 2020
9
Commentary on: Is Banning Texturized Implants to Prevent Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) a Rational Decision? A Meta-Analysis and Cost-Effectiveness Study. 61
32219423 2020
10
Is Banning Texturized Implants to Prevent Breast Implant-Associated Anaplastic Large Cell Lymphoma a Rational Decision? A Meta-Analysis and Cost-Effectiveness Study. 61
31761953 2020
11
Risk of breast implant associated anaplastic large cell lymphoma (BIA-ALCL) in a cohort of 3546 women prospectively followed long term after reconstruction with textured breast implants. 61
32008941 2020
12
Commentary on: Optimizing Breast Pocket Irrigation: The Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Era. 61
31740924 2020
13
Correction to: Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and the Textured Breast Implant Crisis. 61
32372120 2020
14
Editorial on the article "Risk of breast implant associated anaplastic large cell lymphoma in a cohort of 3546 women prospectively followed long term after reconstruction with macro-textured breast implants. 61
32245734 2020
15
Lymphomas arising in immune-privileged sites: insights into biology, diagnosis, and pathogenesis. 61
31863183 2020
16
Review of quality of online resources for breast implant associated anaplastic large cell lymphoma. 61
32473853 2020
17
Breast Implant-associated Anaplastic Large Cell Lymphoma: Review and Multiparametric Imaging Paradigms. 61
32302264 2020
18
European Attitudes and Outcomes Regarding Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Multinational Survey. 61
32367324 2020
19
Breast implant-associated anaplastic large cell lymphoma: emotional impact and guidelines for psychological support. 61
32232699 2020
20
Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma. 61
32414854 2020
21
Optimizing Breast Pocket Irrigation: The Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Era. 61
31501857 2020
22
Breast implant-associated anaplastic large cell lymphoma and the obligation of insurance providers. 61
32436271 2020
23
Breast implant-associated anaplastic large-cell lymphoma: first case detected in a Japanese breast cancer patient. 61
32095988 2020
24
Advances and current concepts in reconstructive surgery for breast cancer. 61
32522379 2020
25
Incidence of Anaplastic Large Cell Lymphoma and Breast-Implant-Associated Lymphoma-An Analysis of a Certified Tumor Registry over 17 Years. 61
32344893 2020
26
Online Patient Resources for Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Readability Analysis. 61
31977528 2020
27
[An algorithmic approach for diagnosis and treatment of breast implant-associated anaplastic large cell lymphoma]. 61
32259859 2020
28
Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): An Open Wound. 61
31932890 2020
29
Best Practices Guideline for the Pathologic Diagnosis of Breast Implant-Associated Anaplastic Large-Cell Lymphoma. 61
32045544 2020
30
The Emerging Crisis of Stakeholders in Implant-based Augmentation Mammaplasty in Korea. 61
32301294 2020
31
Why Do We Need Anatomical Implants? the Science and Rationale for Maintaining Their Availability and Use in Breast Surgery. 61
31897627 2020
32
Public Interest in Textured Breast Implants Recall: A Google Trends Analysis. 61
32356152 2020
33
Reconsideration of the first recognition of breast implant-associated anaplastic large cell lymphoma: A critical review of the literature. 61
32028122 2020
34
Breast magnetic resonance imaging (BMRI) in the diagnosis of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL): Findings beyond late seroma. 61
32166789 2020
35
B-cell lymphomas associated with breast implants: Report of three cases and review of the literature. 61
32315816 2020
36
Breast Implant-associated Anaplastic Large Cell Lymphoma Affecting a Neosubpectoral Pocket. 61
32257718 2020
37
Identifying patients at risk of breast implant-associated anaplastic large cell lymphoma: A commentary. 61
32223041 2020
38
Breast implant-associated anaplastic large cell lymphoma: A comprehensive review. 61
31958739 2020
39
Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and the Textured Breast Implant Crisis. 61
31624894 2020
40
Current Risk Estimate of Breast Implant-Associated Anaplastic Large Cell Lymphoma in Textured Breast Implants. 61
31985673 2020
41
Evaluating the Necessity of Capsulectomy in Cases of Textured Breast Implant Replacement. 61
32102001 2020
42
Capsular synovial metaplasia mimicking radiographic features of implant-associated anaplastic lymphoma. 61
31816541 2020
43
Persistent Extranodal Marginal Zone Lymphoma (MZL) in the Capsule of a Re-explanted Silicone Prosthesis Following Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL). 61
32043335 2020
44
Commentary on: Breast Implant-Associated Anaplastic Large Cell Lymphoma in Australia: A Longitudinal Study of Implant and Other Related Risk Factors. 61
32011676 2020
45
Breast implant-associated anaplastic large cell lymphoma: A rare case report of lymphoma in the form of a pericapsular solid formation. 61
31489733 2020
46
Invited Discussion on: Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and the Textured Implant Crisis. 61
31654091 2020
47
[A historical view of breast implants: Controversy on silicones and breast implant associated -anaplastic large cell lymphoma]. 61
31331682 2020
48
Cell of Origin and Immunologic Events in the Pathogenesis of Breast Implant-Associated Anaplastic Large-Cell Lymphoma. 61
31610171 2020
49
Breast implant-associated anaplastic large cell lymphoma and effusions: A review with emphasis on the role of cytopathology. 61
31899606 2020
50
Commentary on: Validation of a CD30 Enzyme-Linked Immunosorbant Assay for the Rapid Detection of Breast Implant-Associated Anaplastic Large Cell Lymphoma. 61
30789658 2020

Variations for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Expression for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Search GEO for disease gene expression data for Breast Implant-Associated Anaplastic Large Cell Lymphoma.

Pathways for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Pathways related to Breast Implant-Associated Anaplastic Large Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.42 TP53 TNFRSF8 STAT3 JAK1 IL13 CCR6
2
Show member pathways
13.35 TP53 TNFRSF8 STAT3 IL13 CCR6 ALK
3
Show member pathways
13.07 TP53 TNFRSF8 STAT3 JAK1 IL13
4
Show member pathways
12.65 TP53 TNFRSF8 STAT3 JAK1 IL13 CCR6
5 12.44 TP53 STAT3 JAK1 IL13 ALK
6
Show member pathways
12.14 TP53 STAT3 JAK1
7
Show member pathways
12.08 STAT3 JAK1 IL13
8 12.01 TP53 STAT3 JAK1
9
Show member pathways
11.99 TP53 STAT3 JAK1
10 11.87 TP53 STAT3 JAK1
11
Show member pathways
11.7 TP53 STAT3 IL13
12 11.25 TP53 STAT3 JAK1
13 11.12 STAT3 JAK1 IL13
14 11.09 STAT3 JAK1
15 11.01 STAT3 JAK1
16 10.98 TP53 STAT3 JAK1 IL13
17 10.96 STAT3 IL13
18 10.88 TIA1 STAT3 JAK1
19 10.74 STAT3 JAK1

GO Terms for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Biological processes related to Breast Implant-Associated Anaplastic Large Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.58 STAT3 IL13 DNMT3A
2 response to antibiotic GO:0046677 9.49 TP53 JAK1
3 interleukin-7-mediated signaling pathway GO:0038111 9.48 STAT3 JAK1
4 interleukin-6-mediated signaling pathway GO:0070102 9.46 STAT3 JAK1
5 interleukin-15-mediated signaling pathway GO:0035723 9.43 STAT3 JAK1
6 interleukin-35-mediated signaling pathway GO:0070757 9.37 STAT3 JAK1
7 interleukin-27-mediated signaling pathway GO:0070106 9.32 STAT3 JAK1
8 interleukin-9-mediated signaling pathway GO:0038113 9.26 STAT3 JAK1
9 cytokine-mediated signaling pathway GO:0019221 9.26 TP53 STAT3 JAK1 IL13
10 interleukin-21-mediated signaling pathway GO:0038114 9.16 STAT3 JAK1
11 regulation of cell proliferation GO:0042127 8.92 TP53 STAT3 DUSP22 ALK

Molecular functions related to Breast Implant-Associated Anaplastic Large Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase binding GO:0019903 9.13 TP53 STAT3 JAK1
2 CCR5 chemokine receptor binding GO:0031730 8.62 STAT3 JAK1

Sources for Breast Implant-Associated Anaplastic Large Cell Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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