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MCID: BRS112
MIFTS: 34

Breast Implant-Associated Anaplastic Large Cell Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Breast Implant-Associated Anaplastic Large Cell Lymphoma

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MalaCards integrated aliases for Breast Implant-Associated Anaplastic Large Cell Lymphoma:

Name: Breast Implant-Associated Anaplastic Large Cell Lymphoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Blood diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0070333
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Summaries for Breast Implant-Associated Anaplastic Large Cell Lymphoma

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Disease Ontology : 12 A periperal T-cell lymphoma characterized by development around textured-surface breast implants confined to the capsule.

MalaCards based summary : Breast Implant-Associated Anaplastic Large Cell Lymphoma is related to peripheral t-cell lymphoma and anaplastic large cell lymphoma. An important gene associated with Breast Implant-Associated Anaplastic Large Cell Lymphoma is JAK1 (Janus Kinase 1), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. The drugs Cefazolin and Bacitracin have been mentioned in the context of this disorder. Affiliated tissues include breast, t cells and lymph node, and related phenotypes are endocrine/exocrine gland and hematopoietic system

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Related Diseases for Breast Implant-Associated Anaplastic Large Cell Lymphoma

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Diseases related to Breast Implant-Associated Anaplastic Large Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 peripheral t-cell lymphoma 30.0 TP53 STAT3 DNMT3A
2 anaplastic large cell lymphoma 11.3
3 lymphoma 11.1
4 lymphoma, hodgkin, classic 10.6
5 lymphoma, non-hodgkin, familial 10.5
6 li-fraumeni syndrome 10.4
7 li-fraumeni syndrome 2 10.4
8 lymphoproliferative syndrome 10.4
9 t-cell non-hodgkin lymphoma 10.4
10 pfeiffer syndrome 10.2
11 alveolar soft part sarcoma 10.2
12 marginal zone b-cell lymphoma 10.2
13 nodal marginal zone lymphoma 10.2
14 breast lymphoma 10.2
15 hypereosinophilic syndrome 10.2
16 alk-negative anaplastic large cell lymphoma 10.2
17 rare tumor 10.2
18 mixed lacrimal gland cancer 10.1 STAT3 JAK1
19 polycythemia 10.1 STAT3 JAK1
20 combined t cell and b cell immunodeficiency 10.0 STAT3 JAK1
21 bone squamous cell carcinoma 10.0 TP53 STAT3
22 liver benign neoplasm 10.0 TP53 STAT3
23 skin papilloma 10.0 TP53 STAT3
24 cheilitis 10.0 TP53 STAT3
25 prolymphocytic leukemia 10.0 TP53 JAK1
26 colonic benign neoplasm 10.0 TP53 STAT3
27 keratoacanthoma 10.0 TP53 STAT3
28 central nervous system lymphoma 9.9 TP53 STAT3
29 estrogen-receptor positive breast cancer 9.9 TP53 STAT3
30 intestinal benign neoplasm 9.9 TP53 STAT3
31 atrophic gastritis 9.9 TP53 STAT3
32 gastrointestinal system benign neoplasm 9.9 TP53 STAT3
33 cervix carcinoma 9.9 TP53 STAT3
34 chronic leukemia 9.9 STAT3 DNMT3A
35 cervical squamous cell carcinoma 9.9 TP53 STAT3
36 low-grade astrocytoma 9.8 TP53 IL13
37 severe combined immunodeficiency, x-linked 9.8 JAK1 IL13
38 opportunistic mycosis 9.7 STAT3 IL13
39 aging 9.7 TP53 STAT3
40 colonic disease 9.7 TP53 STAT3 JAK1
41 burkitt lymphoma 9.6 TP53 STAT3 JAK1
42 myeloma, multiple 9.6 TP53 STAT3 JAK1
43 leukemia, chronic myeloid 9.6 TP53 STAT3 JAK1
44 schistosomiasis 9.6 TP53 IL13
45 polycythemia vera 9.6 STAT3 JAK1 DNMT3A
46 pancreatic adenocarcinoma 9.6 TP53 STAT3 JAK1
47 myeloid leukemia 9.5 TP53 STAT3 DNMT3A
48 colorectal adenocarcinoma 9.5 TP53 STAT3
49 mouth disease 9.4 TP53 JAK1 IL13
50 esophagitis 9.4 TP53 STAT3 IL13

Graphical network of the top 20 diseases related to Breast Implant-Associated Anaplastic Large Cell Lymphoma:



Diseases related to Breast Implant-Associated Anaplastic Large Cell Lymphoma
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Symptoms & Phenotypes for Breast Implant-Associated Anaplastic Large Cell Lymphoma

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MGI Mouse Phenotypes related to Breast Implant-Associated Anaplastic Large Cell Lymphoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.77 DNMT3A IL13 JAK1 STAT3 TP53
2 hematopoietic system MP:0005397 9.72 DNMT3A IL13 JAK1 STAT3 TP53
3 immune system MP:0005387 9.65 DNMT3A IL13 JAK1 STAT3 TP53
4 muscle MP:0005369 9.46 DNMT3A IL13 STAT3 TP53
5 respiratory system MP:0005388 9.26 IL13 JAK1 STAT3 TP53
6 skeleton MP:0005390 9.02 DNMT3A IL13 JAK1 STAT3 TP53
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Drugs & Therapeutics for Breast Implant-Associated Anaplastic Large Cell Lymphoma

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Drugs for Breast Implant-Associated Anaplastic Large Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefazolin Approved Phase 1 25953-19-9 33255 656510
2
Bacitracin Approved, Vet_approved Phase 1 1405-87-4 439542 10909430
3 Antibiotics, Antitubercular Phase 1
4 Gentamicins Phase 1
5 Anti-Bacterial Agents Phase 1
6 Anti-Infective Agents Phase 1
7 Anti-Infective Agents, Local Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bacterial Biofilms in Reconstructive Breast Prostheses Following Mastectomy Completed NCT03213249 Phase 1 Cefazolin;Gentamicin;Bacitracin
2 Coordination of Rare Diseases at Sanford Recruiting NCT01793168

Search NIH Clinical Center for Breast Implant-Associated Anaplastic Large Cell Lymphoma

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Genetic Tests for Breast Implant-Associated Anaplastic Large Cell Lymphoma

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Anatomical Context for Breast Implant-Associated Anaplastic Large Cell Lymphoma

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MalaCards organs/tissues related to Breast Implant-Associated Anaplastic Large Cell Lymphoma:

40
Breast, T Cells, Lymph Node, Bone Marrow, Bone, Skin, Nk Cells
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Publications for Breast Implant-Associated Anaplastic Large Cell Lymphoma

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Articles related to Breast Implant-Associated Anaplastic Large Cell Lymphoma:

(show top 50) (show all 223)
# Title Authors PMID Year
1
FDG PET/CT and Ultrasound Evaluation of Breast Implant-Associated Anaplastic Large Cell Lymphoma. 61
31693606 2020
2
Breast implant-associated anaplastic large cell lymphoma with lymph node localization: case report and review of literature. 61
30294931 2019
3
Letter to the editor regarding "Current risk estimate of Breast Implant-Associated Anaplastic Large Cell Lymphoma in textured implants". 61
31834258 2019
4
Corrigendum to "EUSOMA position regarding breast implant associated anaplastic large cell lymphoma (BIA-ALCL) and the use of textured implants" [Breast 44 (April 2019) 90-93]. 61
31706463 2019
5
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL): an overview of presentation and pathogenesis and guidelines for pathological diagnosis and management. 61
31166611 2019
6
Revisionary Surgery Following Primary Augmentation Mammoplasty in Muscle Splitting Biplane Pocket: An Appraisal of 93 Revisionary Surgeries. 61
31844939 2019
7
Capsular synovial metaplasia mimicking radiographic features of implant-associated anaplastic lymphoma. 61
31816541 2019
8
Gene alterations in epigenetic modifiers and JAK-STAT signaling are frequent in breast implant-associated ALCL. 61
31774495 2019
9
Is Banning Texturized Implants to Prevent Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) a Rational Decision? A Meta-Analysis and Cost-Effectiveness Study. 61
31761953 2019
10
Commentary on: Optimizing Breast Pocket Irrigation: The Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Era. 61
31740924 2019
11
Breast Implant-Associated Anaplastic Large Cell Lymphoma in Australia: A Longitudinal Study of Implant and Other Related Risk Factors. 61
31738381 2019
12
Finding Consensus After Two Decades of Breast Implant-Associated Anaplastic Large Cell Lymphoma. 61
31632211 2019
13
The First Confirmed Case of Breast Implant-Associated Anaplastic Large Cell Lymphoma in Hawai'i. 61
31723941 2019
14
Cytological features of breast implant-associated anaplastic large cell lymphoma in pleural effusion. 61
31348611 2019
15
Primary Mediastinal Nodal and Extranodal Non-Hodgkin Lymphomas: Current Concepts, Historical Evolution, and Useful Diagnostic Approach: Part 1. 61
31567132 2019
16
Primary Mediastinal Nodal and Extranodal Non-Hodgkin Lymphomas: Current Concepts, Historical Evolution, and Useful Diagnostic Approach: Part 2. 61
31567129 2019
17
Breast Implant-Associated Anaplastic Large-Cell Lymphoma: A Case Report 61
31337189 2019
18
Oncogenic Drivers of Breast Implant-Associated Anaplastic Large Cell Lymphoma. 61
31609289 2019
19
Breast implant-associated anaplastic large cell lymphoma, an under-recognised entity. 61
31173460 2019
20
Breast Implant-Associated Anaplastic Large Cell Lymphoma: Real, Rare, but Avoidable. 61
31642879 2019
21
Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and the Textured Breast Implant Crisis. 61
31624894 2019
22
Invited Discussion on: Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and the Textured Implant Crisis. 61
31654091 2019
23
Cell of Origin and Immunologic Events in the Pathogenesis of Breast Implant-Associated Anaplastic Large-Cell Lymphoma. 61
31610171 2019
24
Breast implant-associated anaplastic large cell lymphoma, a systematic review and in-depth evaluation of the current understanding. 61
31373010 2019
25
Risk of breast implant-associated anaplastic large cell lymphoma in patients submitted to breast implantation: A systematic review. 61
31155830 2019
26
Differences in Human Leukocyte Antigen Expression Between Breast Implant-Associated Anaplastic Large Cell Lymphoma Patients and the General Population. 61
30715139 2019
27
Optimizing Breast Pocket Irrigation: The Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Era. 61
31501857 2019
28
Breast implant-associated anaplastic large cell lymphoma: A rare case report of lymphoma in the form of a pericapsular solid formation. 61
31489733 2019
29
Does Breast Implant Associated ALCL begin as a Lymphoproliferative Disorder? 61
31577659 2019
30
Recurrent PDL1 expression and PDL1 (CD274) copy number alterations in breast implant-associated anaplastic large cell lymphomas. 61
31125630 2019
31
Plastic Surgeons Defend Textured Breast Implants at 2019 U.S. Food and Drug Administration Hearing: Why It Is Time to Reconsider. 61
31592028 2019
32
[Thirty-six (36) French cases of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): What do we know about their prosthetic histories, and what conclusions may be drawn?] 61
31331683 2019
33
Breast Implant-Associated Anaplastic Large-Cell Lymphoma: Why Must We Learn About It? 61
31454283 2019
34
Breast implant associated anaplastic large cell lymphoma. 61
31391171 2019
35
How Common Is Breast Implant-Associated Anaplastic Large Cell Lymphoma? First Four Cases in Israel. 61
31474008 2019
36
Breast Implant-Associated Anaplastic Large Cell Lymphoma: Solid Data or Fake News? 61
31474009 2019
37
Breast implant-associated Anaplastic large cell lymphoma (BIA-ALCL): Imaging findings. 61
31111615 2019
38
Insights into the Microbiome of Breast Implants and Periprosthetic Tissue in Breast Implant-Associated Anaplastic Large Cell Lymphoma. 61
31316085 2019
39
[A historical view of breast implants: Controversy on silicones and breast implant associated -anaplastic large cell lymphoma]. 61
31331682 2019
40
CRISPR/Cas9-Mediated Genomic Editing: Implications for Engineering an Animal Model of Breast Implant-Associated Anaplastic Large Cell Lymphoma. 61
31274766 2019
41
A practical cytological approach to the diagnosis of breast-implant associated anaplastic large cell lymphoma. 61
30628128 2019
42
REPLY TO: CRISPR/Cas9-Mediated Genomic Editing: Implications for Engineering an Animal Model of Breast Implant-Associated Anaplastic Large Cell Lymphoma. 61
31274752 2019
43
A Prospective Approach to Inform and Treat 1340 Patients at Risk for BIA-ALCL. 61
31246798 2019
44
Breast implant-associated anaplastic large cell lymphoma and other rare T-cell lymphomas. 61
31187524 2019
45
Erratum: Breast implant-associated anaplastic large cell lymphoma. 61
31309098 2019
46
Breast Implant-Associated Anaplastic Large Cell Lymphoma and Textured Breast Implants. 61
31082846 2019
47
Brentuximab vedotin as monotherapy for unresectable breast implant-associated anaplastic large cell lymphoma. 61
31110735 2019
48
Determining the True Incidence of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): The Need for Accurate Data. 61
30916317 2019
49
The Dutch Breast Implant Registry: Registration of Breast Implant-Associated Anaplastic Large Cell Lymphoma-A Proof of Concept. 61
31033810 2019
50
Discussion: The Dutch Breast Implant Registry: Registration of Breast Implant-Associated Anaplastic Large Cell Lymphoma-A Proof of Concept. 61
31033811 2019
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Variations for Breast Implant-Associated Anaplastic Large Cell Lymphoma

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Expression for Breast Implant-Associated Anaplastic Large Cell Lymphoma

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Search GEO for disease gene expression data for Breast Implant-Associated Anaplastic Large Cell Lymphoma.
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Pathways for Breast Implant-Associated Anaplastic Large Cell Lymphoma

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Pathways related to Breast Implant-Associated Anaplastic Large Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
TGF-Beta Pathway 63
Show member pathways
 13.22 TP53 STAT3 JAK1 IL13
2
Akt Signaling 63
Show member pathways
 13.1 TP53 STAT3 JAK1 IL13
3
Cytokine Signaling in Immune system 65
Show member pathways
 13.04 TP53 STAT3 JAK1 IL13
4
Human cytomegalovirus infection 36
Show member pathways
 12.66 TP53 STAT3 JAK1
5
TCR Signaling (Qiagen) 63
Show member pathways
 12.65 TP53 STAT3 JAK1
6
Endometrial cancer 36
Show member pathways
 12.6 TP53 STAT3 JAK1
7
Measles 36
Show member pathways
 12.56 TP53 STAT3 JAK1
8
ErbB signaling pathway 1 36
Show member pathways
 12.35 TP53 STAT3 JAK1
9
Th17 cell differentiation 36
Show member pathways
 12.31 STAT3 JAK1 IL13
10
Immune response IL-23 signaling pathway 22
Show member pathways
 12.28 TP53 STAT3 JAK1
11
Pathways in cancer 36
12.28 TP53 STAT3 JAK1 IL13
12
MicroRNAs in cancer 36
12.23 TP53 STAT3 DNMT3A
13
Development ERBB-family signaling 22
Show member pathways
 12.2 TP53 STAT3 JAK1
14
Development IGF-1 receptor signaling 22
Show member pathways
 12.07 TP53 STAT3 JAK1
15
IL-17 Family Signaling Pathways 64
Show member pathways
 12.01 STAT3 JAK1 IL13
16
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 11.98 TP53 JAK1 IL13
17
JAK-STAT signaling pathway (KEGG) 36
Show member pathways
 11.97 STAT3 JAK1 IL13
18
Viral carcinogenesis 36
11.94 TP53 STAT3 JAK1
19
Colorectal Cancer Metastasis 63
11.8 TP53 STAT3 JAK1
20
G-protein signaling Ras family GTPases in kinase cascades (scheme) 22
Show member pathways
 11.8 TP53 STAT3 JAK1
21
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.66 STAT3 JAK1
22
IL-6 signaling pathway 1
Show member pathways
 11.62 STAT3 JAK1
23
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.62 STAT3 JAK1
24
Glucocorticoid receptor regulatory network 1
11.59 TP53 IL13
25
MAPK Pathway 70
Show member pathways
 11.59 TP53 STAT3 IL13
26
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.5 STAT3 JAK1
27
TGF-beta Receptor Signaling (WikiPathways) 1
11.43 STAT3 JAK1
28
Interleukin-6 family signaling 65
Show member pathways
 11.43 STAT3 JAK1
29
Interferon type I signaling pathways 1
11.4 STAT3 JAK1
30
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 1
11.32 STAT3 JAK1
31
Th2 Differentiation Pathway 64
11.31 JAK1 IL13
32
Integrated Cancer Pathway 1
11.3 TP53 JAK1
33
IL-7 Signaling Pathway 1
Show member pathways
 11.3 STAT3 JAK1
34
Interleukin-11 Signaling Pathway 1
11.27 STAT3 JAK1
35
Signaling events mediated by TCPTP 1
Show member pathways
 11.24 STAT3 JAK1
36
Jak/STAT Signaling Pathway Intracellular Regulation 64
11.21 STAT3 JAK1
37
Type III Interferon Signaling Pathways 64
Show member pathways
 11.17 STAT3 JAK1
38
IL-10 Pathway 63
11.11 STAT3 JAK1
39
Immune response_IL-6 signaling pathway 22
11.07 STAT3 JAK1
40
Hepatitis C and Hepatocellular Carcinoma 1
11.04 TP53 STAT3 JAK1
41
IL12 signaling mediated by STAT4 1
10.98 STAT3 IL13
42
Interleukin-4 and 13 signaling 65
10.98 TP53 STAT3 JAK1 IL13
43
Interleukin-10 signaling 65
10.82 STAT3 JAK1 IL13
44
Immune response_Oncostatin M signaling via JAK-Stat in human cells 22
10.76 STAT3 JAK1
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GO Terms for Breast Implant-Associated Anaplastic Large Cell Lymphoma

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Biological processes related to Breast Implant-Associated Anaplastic Large Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.72 TP53 STAT3 IL13
2 response to drug GO:0042493 9.7 TP53 STAT3 DNMT3A
3 protein import into nucleus GO:0006606 9.58 TP53 STAT3
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 STAT3 IL13
5 interferon-gamma-mediated signaling pathway GO:0060333 9.57 TP53 JAK1
6 negative regulation of neuron death GO:1901215 9.56 STAT3 IL13
7 cellular response to cytokine stimulus GO:0071345 9.54 STAT3 IL13
8 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.51 TP53 STAT3
9 response to antibiotic GO:0046677 9.49 TP53 JAK1
10 interleukin-7-mediated signaling pathway GO:0038111 9.48 STAT3 JAK1
11 interleukin-6-mediated signaling pathway GO:0070102 9.46 STAT3 JAK1
12 interleukin-15-mediated signaling pathway GO:0035723 9.43 STAT3 JAK1
13 interleukin-35-mediated signaling pathway GO:0070757 9.4 STAT3 JAK1
14 interleukin-27-mediated signaling pathway GO:0070106 9.37 STAT3 JAK1
15 regulation of mitochondrial membrane permeability GO:0046902 9.32 TP53 STAT3
16 interleukin-9-mediated signaling pathway GO:0038113 9.26 STAT3 JAK1
17 cytokine-mediated signaling pathway GO:0019221 9.26 TP53 STAT3 JAK1 IL13
18 interleukin-21-mediated signaling pathway GO:0038114 9.16 STAT3 JAK1
19 response to ethanol GO:0045471 8.92 TP53 STAT3 IL13 DNMT3A

Molecular functions related to Breast Implant-Associated Anaplastic Large Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.43 TP53 STAT3 DNMT3A
2 transcription factor binding GO:0008134 9.33 TP53 STAT3 DNMT3A
3 CCR5 chemokine receptor binding GO:0031730 8.96 STAT3 JAK1
4 protein phosphatase binding GO:0019903 8.8 TP53 STAT3 JAK1
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Sources for Breast Implant-Associated Anaplastic Large Cell Lymphoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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