Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: BRS112
MIFTS: 34

Breast Implant-Associated Anaplastic Large Cell Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Breast Implant-Associated Anaplastic Large Cell Lymphoma

About this section

MalaCards integrated aliases for Breast Implant-Associated Anaplastic Large Cell Lymphoma:

Name: Breast Implant-Associated Anaplastic Large Cell Lymphoma 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Blood diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0070333
Sources

Summaries for Breast Implant-Associated Anaplastic Large Cell Lymphoma

About this section
Disease Ontology : 12 A periperal T-cell lymphoma characterized by development around textured-surface breast implants confined to the capsule.

MalaCards based summary : Breast Implant-Associated Anaplastic Large Cell Lymphoma is related to peripheral t-cell lymphoma and anaplastic large cell lymphoma. An important gene associated with Breast Implant-Associated Anaplastic Large Cell Lymphoma is JAK1 (Janus Kinase 1), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. The drugs Cefazolin and Bacitracin have been mentioned in the context of this disorder. Affiliated tissues include breast, t cells and bone, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Sources

Related Diseases for Breast Implant-Associated Anaplastic Large Cell Lymphoma

About this section

Diseases related to Breast Implant-Associated Anaplastic Large Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 peripheral t-cell lymphoma 30.0 TP53 STAT3 DNMT3A
2 anaplastic large cell lymphoma 11.3
3 lymphoma 11.1
4 lymphoma, hodgkin, classic 10.6
5 lymphoma, non-hodgkin, familial 10.5
6 li-fraumeni syndrome 10.4
7 li-fraumeni syndrome 2 10.4
8 lymphoproliferative syndrome 10.4
9 t-cell non-hodgkin lymphoma 10.4
10 pfeiffer syndrome 10.2
11 alveolar soft part sarcoma 10.2
12 marginal zone b-cell lymphoma 10.2
13 nodal marginal zone lymphoma 10.2
14 breast lymphoma 10.2
15 hypereosinophilic syndrome 10.2
16 lymphoma aids related 10.2
17 alk-negative anaplastic large cell lymphoma 10.2
18 rare tumor 10.2
19 mixed lacrimal gland cancer 10.1 STAT3 JAK1
20 polycythemia 10.1 STAT3 JAK1
21 combined t cell and b cell immunodeficiency 10.0 STAT3 JAK1
22 bone squamous cell carcinoma 10.0 TP53 STAT3
23 liver benign neoplasm 10.0 TP53 STAT3
24 skin papilloma 10.0 TP53 STAT3
25 cheilitis 10.0 TP53 STAT3
26 prolymphocytic leukemia 10.0 TP53 JAK1
27 colonic benign neoplasm 10.0 TP53 STAT3
28 keratoacanthoma 10.0 TP53 STAT3
29 central nervous system lymphoma 9.9 TP53 STAT3
30 estrogen-receptor positive breast cancer 9.9 TP53 STAT3
31 intestinal benign neoplasm 9.9 TP53 STAT3
32 atrophic gastritis 9.9 TP53 STAT3
33 gastrointestinal system benign neoplasm 9.9 TP53 STAT3
34 cervix carcinoma 9.9 TP53 STAT3
35 chronic leukemia 9.9 STAT3 DNMT3A
36 cervical squamous cell carcinoma 9.9 TP53 STAT3
37 low-grade astrocytoma 9.8 TP53 IL13
38 severe combined immunodeficiency, x-linked 9.8 JAK1 IL13
39 opportunistic mycosis 9.7 STAT3 IL13
40 aging 9.7 TP53 STAT3
41 colonic disease 9.7 TP53 STAT3 JAK1
42 burkitt lymphoma 9.6 TP53 STAT3 JAK1
43 myeloma, multiple 9.6 TP53 STAT3 JAK1
44 leukemia, chronic myeloid 9.6 TP53 STAT3 JAK1
45 schistosomiasis 9.6 TP53 IL13
46 polycythemia vera 9.6 STAT3 JAK1 DNMT3A
47 pancreatic adenocarcinoma 9.6 TP53 STAT3 JAK1
48 myeloid leukemia 9.5 TP53 STAT3 DNMT3A
49 colorectal adenocarcinoma 9.5 TP53 STAT3
50 mouth disease 9.4 TP53 JAK1 IL13

Graphical network of the top 20 diseases related to Breast Implant-Associated Anaplastic Large Cell Lymphoma:



Diseases related to Breast Implant-Associated Anaplastic Large Cell Lymphoma
Sources

Symptoms & Phenotypes for Breast Implant-Associated Anaplastic Large Cell Lymphoma

About this section

MGI Mouse Phenotypes related to Breast Implant-Associated Anaplastic Large Cell Lymphoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.77 DNMT3A IL13 JAK1 STAT3 TP53
2 hematopoietic system MP:0005397 9.72 DNMT3A IL13 JAK1 STAT3 TP53
3 immune system MP:0005387 9.65 DNMT3A IL13 JAK1 STAT3 TP53
4 muscle MP:0005369 9.46 DNMT3A IL13 STAT3 TP53
5 respiratory system MP:0005388 9.26 IL13 JAK1 STAT3 TP53
6 skeleton MP:0005390 9.02 DNMT3A IL13 JAK1 STAT3 TP53
Sources

Drugs & Therapeutics for Breast Implant-Associated Anaplastic Large Cell Lymphoma

About this section

Drugs for Breast Implant-Associated Anaplastic Large Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefazolin Approved Phase 1 25953-19-9 656510 33255
2
Bacitracin Approved, Vet_approved Phase 1 1405-87-4 439542 10909430
3 Anti-Bacterial Agents Phase 1
4 Antibiotics, Antitubercular Phase 1
5 Gentamicins Phase 1
6 Anti-Infective Agents, Local Phase 1
7 Anti-Infective Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bacterial Biofilms in Reconstructive Breast Prostheses Following Mastectomy Completed NCT03213249 Phase 1 Cefazolin;Gentamicin;Bacitracin
2 Coordination of Rare Diseases at Sanford Recruiting NCT01793168

Search NIH Clinical Center for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Sources

Genetic Tests for Breast Implant-Associated Anaplastic Large Cell Lymphoma

About this section
Sources

Anatomical Context for Breast Implant-Associated Anaplastic Large Cell Lymphoma

About this section

MalaCards organs/tissues related to Breast Implant-Associated Anaplastic Large Cell Lymphoma:

40
Breast, T Cells, Bone, Myeloid, Bone Marrow, Skin, Colon
Sources

Publications for Breast Implant-Associated Anaplastic Large Cell Lymphoma

About this section

Articles related to Breast Implant-Associated Anaplastic Large Cell Lymphoma:

(show top 50) (show all 240)
# Title Authors PMID Year
1
Current Risk Estimate of Breast Implant-Associated Anaplastic Large Cell Lymphoma in Textured Breast Implants. 61
31985673 2020
2
Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and the Textured Breast Implant Crisis. 61
31624894 2020
3
Invited Discussion on: Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and the Textured Implant Crisis. 61
31654091 2020
4
Commentary on: Breast Implant-Associated Anaplastic Large Cell Lymphoma in Australia: A Longitudinal Study of Implant and Other Related Risk Factors. 61
32011676 2020
5
Capsular synovial metaplasia mimicking radiographic features of implant-associated anaplastic lymphoma. 61
31816541 2020
6
Does Breast Implant-Associated ALCL Begin as a Lymphoproliferative Disorder? 61
31577659 2020
7
Why Do We Need Anatomical Implants? the Science and Rationale for Maintaining Their Availability and Use in Breast Surgery. 61
31897627 2020
8
Risk of breast implant associated anaplastic large cell lymphoma (BIA-ALCL) in a cohort of 3546 women prospectively followed long term after reconstruction with textured breast implants. 61
32008941 2020
9
Commentary on: Validation of a CD30 Enzyme-Linked Immunosorbant Assay for the Rapid Detection of Breast Implant-Associated Anaplastic Large Cell Lymphoma. 61
30789658 2020
10
Reconsideration of the first recognition of breast implant-associated anaplastic large cell lymphoma: A critical review of the literature. 61
32028122 2020
11
Device-Specific Findings of Imprinted-Texture Breast Implants: Characteristics, Risks, and Benefits. 61
31121016 2020
12
Kikuchi-Fujimoto Disease-Like Inflammatory Reaction in a Silicone Breast Implant Seroma. 61
31962314 2020
13
Gene alterations in epigenetic modifiers and JAK-STAT signaling are frequent in breast implant-associated ALCL. 61
31774495 2020
14
Breast implant-associated anaplastic large cell lymphoma and effusions: A review with emphasis on the role of cytopathology. 61
31899606 2020
15
Cell of Origin and Immunologic Events in the Pathogenesis of Breast Implant-Associated Anaplastic Large-Cell Lymphoma. 61
31610171 2020
16
FDG PET/CT and Ultrasound Evaluation of Breast Implant-Associated Anaplastic Large Cell Lymphoma. 61
31693606 2020
17
Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): An Open Wound. 61
31932890 2020
18
A Cautionary Tale and Update on Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL). 61
31894234 2020
19
Online Patient Resources for Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Readability Analysis. 61
31977528 2020
20
Validation of a CD30 Enzyme-Linked Immunosorbant Assay for the Rapid Detection of Breast Implant-Associated Anaplastic Large Cell Lymphoma. 61
30789639 2020
21
Breast implant-associated anaplastic large cell lymphoma: A comprehensive review. 61
31958739 2020
22
Breast Implant-Associated Anaplastic Large Cell Lymphoma. 61
31894932 2020
23
Oncogenic Drivers of Breast Implant-Associated Anaplastic Large Cell Lymphoma. 61
31609289 2020
24
Breast implant-associated anaplastic large cell lymphoma with lymph node localization: case report and review of literature. 61
30294931 2019
25
Letter to the editor regarding "Current risk estimate of Breast Implant-Associated Anaplastic Large Cell Lymphoma in textured implants". 61
31834258 2019
26
Revisionary Surgery Following Primary Augmentation Mammoplasty in Muscle Splitting Biplane Pocket: An Appraisal of 93 Revisionary Surgeries. 61
31844939 2019
27
Lymphomas arising in immune-privileged sites: insights into biology, diagnosis, and pathogenesis. 61
31863183 2019
28
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL): an overview of presentation and pathogenesis and guidelines for pathological diagnosis and management. 61
31166611 2019
29
A Rebuttal of Antibiotic Irrigation as a Method to Reduce Risk of Capsular Contracture and Breast Implant-Associated Anaplastic Large-Cell Lymphoma. 61
31855865 2019
30
Corrigendum to "EUSOMA position regarding breast implant associated anaplastic large cell lymphoma (BIA-ALCL) and the use of textured implants" [Breast 44 (April 2019) 90-93]. 61
31706463 2019
31
Is Banning Texturized Implants to Prevent Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) a Rational Decision? A Meta-Analysis and Cost-Effectiveness Study. 61
31761953 2019
32
Breast Implant-Associated Anaplastic Large Cell Lymphoma in Australia: A Longitudinal Study of Implant and Other Related Risk Factors. 61
31738381 2019
33
Commentary on: Optimizing Breast Pocket Irrigation: The Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Era. 61
31740924 2019
34
Finding Consensus After Two Decades of Breast Implant-Associated Anaplastic Large Cell Lymphoma. 61
31632211 2019
35
The First Confirmed Case of Breast Implant-Associated Anaplastic Large Cell Lymphoma in Hawai'i. 61
31723941 2019
36
Breast Implant-Associated Anaplastic Large-Cell Lymphoma: A Case Report 61
31337189 2019
37
Primary Mediastinal Nodal and Extranodal Non-Hodgkin Lymphomas: Current Concepts, Historical Evolution, and Useful Diagnostic Approach: Part 1. 61
31567132 2019
38
Primary Mediastinal Nodal and Extranodal Non-Hodgkin Lymphomas: Current Concepts, Historical Evolution, and Useful Diagnostic Approach: Part 2. 61
31567129 2019
39
Cytological features of breast implant-associated anaplastic large cell lymphoma in pleural effusion. 61
31348611 2019
40
Breast implant-associated anaplastic large cell lymphoma, an under-recognised entity. 61
31173460 2019
41
Breast Implant-Associated Anaplastic Large Cell Lymphoma: Real, Rare, but Avoidable. 61
31642879 2019
42
Risk of breast implant-associated anaplastic large cell lymphoma in patients submitted to breast implantation: A systematic review. 61
31155830 2019
43
Breast implant-associated anaplastic large cell lymphoma, a systematic review and in-depth evaluation of the current understanding. 61
31373010 2019
44
Differences in Human Leukocyte Antigen Expression Between Breast Implant-Associated Anaplastic Large Cell Lymphoma Patients and the General Population. 61
30715139 2019
45
Stage IV Breast Implant-associated Anaplastic Large-cell Lymphoma with Complete Pathologic Response to Neoadjuvant Chemotherapy. 61
31942403 2019
46
Optimizing Breast Pocket Irrigation: The Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Era. 61
31501857 2019
47
Breast implant-associated anaplastic large cell lymphoma: A rare case report of lymphoma in the form of a pericapsular solid formation. 61
31489733 2019
48
Recurrent PDL1 expression and PDL1 (CD274) copy number alterations in breast implant-associated anaplastic large cell lymphomas. 61
31125630 2019
49
[Thirty-six (36) French cases of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): What do we know about their prosthetic histories, and what conclusions may be drawn?] 61
31331683 2019
50
Plastic Surgeons Defend Textured Breast Implants at 2019 U.S. Food and Drug Administration Hearing: Why It Is Time to Reconsider. 61
31592028 2019
Sources

Variations for Breast Implant-Associated Anaplastic Large Cell Lymphoma

About this section
Sources

Expression for Breast Implant-Associated Anaplastic Large Cell Lymphoma

About this section
Search GEO for disease gene expression data for Breast Implant-Associated Anaplastic Large Cell Lymphoma.
Sources

Pathways for Breast Implant-Associated Anaplastic Large Cell Lymphoma

About this section

Pathways related to Breast Implant-Associated Anaplastic Large Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
TGF-Beta Pathway 63
Show member pathways
 13.22 TP53 STAT3 JAK1 IL13
2
Akt Signaling 63
Show member pathways
 13.1 TP53 STAT3 JAK1 IL13
3
Cytokine Signaling in Immune system 65
Show member pathways
 13.04 TP53 STAT3 JAK1 IL13
4
Human cytomegalovirus infection 36
Show member pathways
 12.66 TP53 STAT3 JAK1
5
TCR Signaling (Qiagen) 63
Show member pathways
 12.65 TP53 STAT3 JAK1
6
Endometrial cancer 36
Show member pathways
 12.6 TP53 STAT3 JAK1
7
Measles 36
Show member pathways
 12.56 TP53 STAT3 JAK1
8
ErbB signaling pathway 1 36
Show member pathways
 12.35 TP53 STAT3 JAK1
9
Th17 cell differentiation 36
Show member pathways
 12.31 STAT3 JAK1 IL13
10
Immune response IL-23 signaling pathway 22
Show member pathways
 12.28 TP53 STAT3 JAK1
11
Pathways in cancer 36
12.28 TP53 STAT3 JAK1 IL13
12
MicroRNAs in cancer 36
12.23 TP53 STAT3 DNMT3A
13
Development ERBB-family signaling 22
Show member pathways
 12.2 TP53 STAT3 JAK1
14
Development IGF-1 receptor signaling 22
Show member pathways
 12.07 TP53 STAT3 JAK1
15
IL-17 Family Signaling Pathways 64
Show member pathways
 12.01 STAT3 JAK1 IL13
16
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 11.98 TP53 JAK1 IL13
17
JAK-STAT signaling pathway (KEGG) 36
Show member pathways
 11.97 STAT3 JAK1 IL13
18
Viral carcinogenesis 36
11.94 TP53 STAT3 JAK1
19
Colorectal Cancer Metastasis 63
11.8 TP53 STAT3 JAK1
20
G-protein signaling Ras family GTPases in kinase cascades (scheme) 22
Show member pathways
 11.8 TP53 STAT3 JAK1
21
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.66 STAT3 JAK1
22
IL-6 signaling pathway 1
Show member pathways
 11.62 STAT3 JAK1
23
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.62 STAT3 JAK1
24
Glucocorticoid receptor regulatory network 1
11.59 TP53 IL13
25
MAPK Pathway 70
Show member pathways
 11.59 TP53 STAT3 IL13
26
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.5 STAT3 JAK1
27
TGF-beta Receptor Signaling (WikiPathways) 1
11.43 STAT3 JAK1
28
Interleukin-6 family signaling 65
Show member pathways
 11.43 STAT3 JAK1
29
Interferon type I signaling pathways 1
11.4 STAT3 JAK1
30
Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 1
11.32 STAT3 JAK1
31
Th2 Differentiation Pathway 64
11.31 JAK1 IL13
32
Integrated Cancer Pathway 1
11.3 TP53 JAK1
33
IL-7 Signaling Pathway 1
Show member pathways
 11.3 STAT3 JAK1
34
Interleukin-11 Signaling Pathway 1
11.27 STAT3 JAK1
35
Signaling events mediated by TCPTP 1
Show member pathways
 11.24 STAT3 JAK1
36
Jak/STAT Signaling Pathway Intracellular Regulation 64
11.21 STAT3 JAK1
37
Type III Interferon Signaling Pathways 64
Show member pathways
 11.17 STAT3 JAK1
38
IL-10 Pathway 63
11.11 STAT3 JAK1
39
Immune response_IL-6 signaling pathway 22
11.07 STAT3 JAK1
40
Hepatitis C and Hepatocellular Carcinoma 1
11.04 TP53 STAT3 JAK1
41
IL12 signaling mediated by STAT4 1
10.98 STAT3 IL13
42
Interleukin-4 and 13 signaling 65
10.98 TP53 STAT3 JAK1 IL13
43
Interleukin-10 signaling 65
10.82 STAT3 JAK1 IL13
44
Immune response_Oncostatin M signaling via JAK-Stat in human cells 22
10.76 STAT3 JAK1
Sources

GO Terms for Breast Implant-Associated Anaplastic Large Cell Lymphoma

About this section

Biological processes related to Breast Implant-Associated Anaplastic Large Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.72 TP53 STAT3 IL13
2 response to drug GO:0042493 9.7 TP53 STAT3 DNMT3A
3 protein import into nucleus GO:0006606 9.58 TP53 STAT3
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 STAT3 IL13
5 interferon-gamma-mediated signaling pathway GO:0060333 9.57 TP53 JAK1
6 negative regulation of neuron death GO:1901215 9.56 STAT3 IL13
7 cellular response to cytokine stimulus GO:0071345 9.54 STAT3 IL13
8 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.51 TP53 STAT3
9 response to antibiotic GO:0046677 9.49 TP53 JAK1
10 interleukin-7-mediated signaling pathway GO:0038111 9.48 STAT3 JAK1
11 interleukin-6-mediated signaling pathway GO:0070102 9.46 STAT3 JAK1
12 interleukin-15-mediated signaling pathway GO:0035723 9.43 STAT3 JAK1
13 interleukin-35-mediated signaling pathway GO:0070757 9.4 STAT3 JAK1
14 interleukin-27-mediated signaling pathway GO:0070106 9.37 STAT3 JAK1
15 regulation of mitochondrial membrane permeability GO:0046902 9.32 TP53 STAT3
16 interleukin-9-mediated signaling pathway GO:0038113 9.26 STAT3 JAK1
17 cytokine-mediated signaling pathway GO:0019221 9.26 TP53 STAT3 JAK1 IL13
18 interleukin-21-mediated signaling pathway GO:0038114 9.16 STAT3 JAK1
19 response to ethanol GO:0045471 8.92 TP53 STAT3 IL13 DNMT3A

Molecular functions related to Breast Implant-Associated Anaplastic Large Cell Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.43 TP53 STAT3 DNMT3A
2 transcription factor binding GO:0008134 9.33 TP53 STAT3 DNMT3A
3 CCR5 chemokine receptor binding GO:0031730 8.96 STAT3 JAK1
4 protein phosphatase binding GO:0019903 8.8 TP53 STAT3 JAK1
Sources

Sources for Breast Implant-Associated Anaplastic Large Cell Lymphoma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....