Breast Implant-Associated Anaplastic Large Cell Lymphoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BRS112 MIFTS: 35	Breast Implant-Associated Anaplastic Large Cell Lymphoma Categories: Blood diseases, Cancer diseases, Immune diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Breast Implant-Associated Anaplastic Large Cell Lymphoma

MalaCards integrated aliases for Breast Implant-Associated Anaplastic Large Cell Lymphoma:

Name: Breast Implant-Associated Anaplastic Large Cell Lymphoma ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Immune diseases Blood diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0070333

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Summaries for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Disease Ontology : ¹² A periperal T-cell lymphoma characterized by development around textured-surface breast implants confined to the capsule.

MalaCards based summary : Breast Implant-Associated Anaplastic Large Cell Lymphoma is related to anaplastic large cell lymphoma and breast lymphoma. An important gene associated with Breast Implant-Associated Anaplastic Large Cell Lymphoma is JAK1 (Janus Kinase 1), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Cefazolin and Bacitracin have been mentioned in the context of this disorder. Affiliated tissues include breast, t cells and lymph node, and related phenotypes are hematopoietic system and endocrine/exocrine gland

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Related Diseases for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Diseases related to Breast Implant-Associated Anaplastic Large Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)

#	Related Disease	Score	Top Affiliating Genes
1	anaplastic large cell lymphoma	31.3	TNFRSF8 TIA1 STAT3 ALK
2	breast lymphoma	30.4	TNFRSF8 ALK
3	alk-negative anaplastic large cell lymphoma	29.9	STAT3 DUSP22 ALK
4	lymphoma	29.8	TP53 TNFRSF8 TIA1 STAT3 CCR6 ALK
5	lymphoma, non-hodgkin, familial	29.6	TP53 TNFRSF8 STAT3 CCR6 ALK
6	lymphoma, hodgkin, classic	29.4	TNFRSF8 TIA1 IL13 CCR6 ALK
7	peripheral t-cell lymphoma	28.3	TP53 TNFRSF8 TIA1 STAT3 DUSP22 DNMT3A
8	li-fraumeni syndrome	10.4
9	li-fraumeni syndrome 2	10.4
10	lymphoproliferative syndrome	10.4
11	t-cell non-hodgkin lymphoma	10.4
12	mixed lacrimal gland cancer	10.4	STAT3 JAK1
13	marginal zone b-cell lymphoma	10.3
14	bone squamous cell carcinoma	10.3	TP53 STAT3
15	liver benign neoplasm	10.2	TP53 STAT3
16	marek disease	10.2	TP53 TNFRSF8
17	intratubular embryonal carcinoma	10.2	TP53 TNFRSF8
18	papilledema	10.2	TP53 STAT3
19	low-grade astrocytoma	10.2	TP53 IL13
20	conventional fibrosarcoma	10.2	TP53 TNFRSF8
21	lymphosarcoma	10.2	TNFRSF8 DNMT3A
22	sarcomatoid transitional cell carcinoma	10.2	TP53 ALK
23	pfeiffer syndrome	10.2
24	alveolar soft part sarcoma	10.2
25	nodal marginal zone lymphoma	10.2
26	breast disease	10.2
27	hypereosinophilic syndrome	10.2
28	lymphoma aids related	10.2
29	hypoxia	10.2
30	rare tumor	10.2
31	parameningeal embryonal rhabdomyosarcoma	10.2	TP53 ALK
32	aggressive nk-cell leukemia	10.1	TIA1 STAT3
33	carbapenem allergy	10.1	IL13 ALK
34	mature teratoma	10.1	TP53 TNFRSF8
35	bone lymphoma	10.1	TNFRSF8 ALK
36	lethal midline granuloma	10.1	TNFRSF8 TIA1
37	pleural lipoma	10.1	TNFRSF8 ALK
38	adult lymphoma	10.1	TNFRSF8 ALK
39	hyper ige recurrent infection syndrome 1	10.1	STAT3 CCR6
40	composite lymphoma	10.1	TNFRSF8 TIA1
41	primary cutaneous anaplastic large cell lymphoma	10.0	TIA1 ALK
42	polycythemia vera	10.0	STAT3 JAK1 DNMT3A
43	esophagitis	10.0	TP53 STAT3 IL13
44	mikulicz disease	10.0	IL13 CCR6
45	nut allergy	10.0	IL13 CCR6
46	nasopharyngitis	10.0	JAK1 CCR6
47	cll/sll	10.0	TP53 CCR6
48	dacryoadenitis	10.0	IL13 CCR6
49	egg allergy	10.0	IL13 CCR6
50	systemic mastocytosis	10.0	TNFRSF8 STAT3 DNMT3A

Graphical network of the top 20 diseases related to Breast Implant-Associated Anaplastic Large Cell Lymphoma:

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Symptoms & Phenotypes for Breast Implant-Associated Anaplastic Large Cell Lymphoma

MGI Mouse Phenotypes related to Breast Implant-Associated Anaplastic Large Cell Lymphoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.91	CCR6 DNMT3A DUSP22 IL13 JAK1 STAT3
2	endocrine/exocrine gland	MP:0005379	9.87	ALK DNMT3A IL13 JAK1 STAT3 TNFRSF8
3	immune system	MP:0005387	9.81	CCR6 DNMT3A DUSP22 IL13 JAK1 STAT3
4	respiratory system	MP:0005388	9.43	ALK DUSP22 IL13 JAK1 STAT3 TP53
5	skeleton	MP:0005390	9.17	ALK DNMT3A IL13 JAK1 STAT3 TIA1

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Drugs & Therapeutics for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Drugs for Breast Implant-Associated Anaplastic Large Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Cefazolin

Approved

Phase 1

25953-19-9

656510 33255

Synonyms:

(6R, 7R)-3-[[(5-Methyl-1,3,4-thiadiazol-2- yl)thio]methyl]-8-oxo-7-[[1H-tetrazol-1- yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2- ene-2-carboxylic acid

(6R,7R)-3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid

(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

(6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulphanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

(6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulphanyl]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R,7R)-3-{[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl}-8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R-trans)-3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(((1H-tetrazol-1-yl)acetyl)-amino)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid

25953-19-9

27164-46-1

3-{[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-7beta-[(1H-tetrazol-1-ylacetyl)amino]-3,4-didehydrocepham-4-carboxylic acid

7-(1-(1H-)-Tetrazolylacetamido)-3-(2-(5-methyl-1,3,4-thiadiazolyl)thiomethyl)delta3-cephem-4-carboxylic acid

AC-16010

AC1L1P98

AC1Q6LOT

Ancef

Bio-0576

BPBio1_000762

BRN 4169371

BSPBio_000692

BSPBio_001939

C06880

C14H14N8O4S3

Cefamedin

Cefamezin

Cefamezine

cefazolin

Cefazolin

Cefazolin (USP)

Cefazolin [USAN:INN]

Cefazolin sodium

cefazolin(usp)

Cefazolina

Cefazolina [INN-Spanish]

Cefazoline

Cefazoline [INN-French]

Cefazolinum

Cefazolinum [INN-Latin]

Cephamezine

Cephazolidin

Cephazolin

Cephazolin sodium

Cephazolin Sodium

Cephazolin, sodium

Cephazoline

CEZ

CHEBI:474053

CHEMBL1435

CID33255

D02299

DivK1c_000014

EINECS 247-362-8

Elzogram

Gramaxin

HSDB 3213

IDI1_000014

KBio1_000014

KBio2_000546

KBio2_003114

KBio2_005682

KBio3_001159

KBioGR_000734

KBioSS_000546

Kefzol

Lopac0_000274

LS-150084

MLS001032060

MLS001049010

MolPort-002-507-461

NCGC00159465-02

NINDS_000014

NSC291561

Prestwick0_000736

Prestwick1_000736

Prestwick2_000736

Prestwick3_000736

SMR000387025

Sodium cephazolin

Sodium, cefazolin

Sodium, cephazolin

SPBio_001039

SPBio_002631

Spectrum_000106

Spectrum2_001140

Spectrum3_000330

Spectrum4_000267

Spectrum5_000665

Totacef

UNII-IHS69L0Y4T

Bacitracin

Approved, Vet_approved

Phase 1

1405-87-4

439542 10909430

Synonyms:

(4R)-4-[[(2S)-2-[[(4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazole-4-carbonyl]amino]-4-methylpentanoyl]amino]-5-[[(2S,3S)-1-[[(3S,6R,9S,12R,15R,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-15-[(2S)-butan-2-yl]-6-(carboxymethyl)-9-(1H-imidazol-5-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclopentacos-21-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid

(4R)-4-[[(2S)-2-[[2-(1-amino-2-methylbutyl)-4,5-dihydro-1,3-thiazole-4-carbonyl]amino]-4-methylpentanoyl]amino]-5-[[(2S,3S)-1-[[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-15-[(2S)-butan-2-yl]-6-(carboxymethyl)-9-(1H-imidazol-5-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclopentacos-21-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid

11702_FLUKA

11702_SIGMA

22601-59-8

4-[[2-[[2-(1-amino-2-methylbutyl)-4,5-dihydro-1,3-thiazole-4-carbonyl]amino]-4-methylpentanoyl]amino]-5-[[1-[[3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-15-butan-2-yl-6-(carboxymethyl)-9-(1H-imidazol-5-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclopentacos-21-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid

46084_RIEDEL

A.L. labs brand OF bacitracin zinc salt

AB00513964

AC1L22YV

AC1O6F67

AC1O8Q0J

AC1Q6GKZ

Ak tracin

Akorn brand OF bacitracin

Ak-tracin

Altracin

B0125_SIGMA

Baci im

Baci RX

Baciguent

Baci-im

Baciquent

Baci-RX

Bacitin

bacitracin

Bacitracin

Bacitracin a

Bacitracin A

Bacitracin A1

Bacitracin a2a

Bacitracin A2a

Bacitracin akorn brand

Bacitracin dioptic brand

Bacitracin lee brand

Bacitracin mcneil brand

Bacitracin pharmascience brand

Bacitracin zinc

Bacitracin zinc complex

Bacitracin, zinc

Bacitracina

Bacitracine martinet

BPBio1_000878

BSPBio_000798

C15482

CHEMBL1200558

Ciba vision brand OF bacitracin

CID10909430

CID6474109

CID65281

CID6714010

Citracin

Dioptic brand OF bacitracin

EINECS 245-115-9

Fortracin

HMS1570H20

L-Asparagine, N-[[(4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-4-thiazolyl]carbonyl]-L-leucyl-D-.alpha.-glutamyl-L-isoleucyl-L-lysyl-D-ornithyl-L-isoleucyl-D-phenylalanyl-L-histidyl-D-.alpha.-as

Lee brand OF bacitracin

LS-23608

Martinet, bacitracine

McNeil brand OF bacitracin

MLS002695992

MolPort-003-926-019

n-{[2-(1-amino-2-methylbutyl)-4,5-dihydro-1,3-thiazol-4-yl]carbonyl}leucyl-|A-glutamyl-n-[3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-15-(butan-2-yl)-6-(carboxymethyl)-9-(1h-imidazol-5-ylmethyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclopentacosan-21-yl]isoleucinamide

NSC 45737

Ocu tracin

Ocumed brand OF bacitracin

Ocu-tracin

OcuTracin

partyl-, (10.4)-lactam

Pharma tek brand OF bacitracin

Pharmascience brand OF bacitracin

Prestwick1_000919

Prestwick2_000919

Prestwick3_000919

Reed and carnrick brand OF bacitracin

SMR001562136

Solu-Tracin 50

SPBio_002987

Topitracin

UNII-DDA3RRX0P7

Zeba RX

Zeba-RX

Zinc bacitracin

Zinc, bacitracin

Anti-Bacterial Agents

Phase 1

Anti-Infective Agents, Local

Phase 1

Gentamicins

Phase 1

Antibiotics, Antitubercular

Phase 1

Anti-Infective Agents

Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Bacterial Biofilms in Reconstructive Breast Prostheses Following Mastectomy	Completed	NCT03213249	Phase 1	Cefazolin;Gentamicin;Bacitracin
2	Breast Implant-associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Registry	Recruiting	NCT04220970
3	Coordination of Rare Diseases at Sanford	Recruiting	NCT01793168

Search NIH Clinical Center for Breast Implant-Associated Anaplastic Large Cell Lymphoma

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Genetic Tests for Breast Implant-Associated Anaplastic Large Cell Lymphoma

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Anatomical Context for Breast Implant-Associated Anaplastic Large Cell Lymphoma

MalaCards organs/tissues related to Breast Implant-Associated Anaplastic Large Cell Lymphoma:

⁴⁰

Breast, T Cells, Lymph Node, Bone Marrow, Bone, Skin, Nk Cells

Sources

Publications for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Articles related to Breast Implant-Associated Anaplastic Large Cell Lymphoma:

(show top 50) (show all 272)

#	Title	Authors	PMID	Year
1	Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Prospective Series of 52 Patients. ⁶¹	Tevis SE...Clemens MW	32568749	2020
2	The flow cytometric characteristics of breast implant-associated anaplastic large cell lymphoma. ⁶¹	Barr J...Cochrane T	32525554	2020
3	A Novel JAK1 Mutant Breast Implant-Associated Anaplastic Large Cell Lymphoma Patient-Derived Xenograft Fostering Pre-Clinical Discoveries. ⁶¹	Fiore D...Inghirami G	32560455	2020
4	Additional Thoughts on Banning Textured Implants to Prevent Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL). ⁶¹	Munhoz AM	32538433	2020
5	Response to "Additional Thoughts on Banning Textured Implants to Prevent Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL)". ⁶¹	Danilla SV...Albornoz CR	32539078	2020
6	Should Flow Cytometry Be Considered a First Line of Study in the Diagnosis of Breast Implant-Associated Anaplastic Large-Cell Lymphoma? ⁶¹	Romero M...Saavedra C	32552470	2020
7	Commentary on: Is Banning Texturized Implants to Prevent Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) a Rational Decision? A Meta-Analysis and Cost-Effectiveness Study. ⁶¹	Hollrah R	32129816	2020
8	Commentary on: Is Banning Texturized Implants to Prevent Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) a Rational Decision? A Meta-Analysis and Cost-Effectiveness Study. ⁶¹	Clemens MW...Knittel CR	32129817	2020
9	Commentary on: Is Banning Texturized Implants to Prevent Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) a Rational Decision? A Meta-Analysis and Cost-Effectiveness Study. ⁶¹	Magnusson MR	32219423	2020
10	Is Banning Texturized Implants to Prevent Breast Implant-Associated Anaplastic Large Cell Lymphoma a Rational Decision? A Meta-Analysis and Cost-Effectiveness Study. ⁶¹	Danilla SV...Albornoz CR	31761953	2020
11	Risk of breast implant associated anaplastic large cell lymphoma (BIA-ALCL) in a cohort of 3546 women prospectively followed long term after reconstruction with textured breast implants. ⁶¹	Cordeiro PG...Horwitz SM	32008941	2020
12	Commentary on: Optimizing Breast Pocket Irrigation: The Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Era. ⁶¹	Walker JN...Myckatyn TM	31740924	2020
13	Correction to: Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and the Textured Breast Implant Crisis. ⁶¹	Groth AK...Graf R	32372120	2020
14	Editorial on the article "Risk of breast implant associated anaplastic large cell lymphoma in a cohort of 3546 women prospectively followed long term after reconstruction with macro-textured breast implants. ⁶¹	Mercer NSG	32245734	2020
15	Lymphomas arising in immune-privileged sites: insights into biology, diagnosis, and pathogenesis. ⁶¹	King RL...Ferry JA	31863183	2020
16	Review of quality of online resources for breast implant associated anaplastic large cell lymphoma. ⁶¹	McMahon ME...Hanson RP	32473853	2020
17	Breast Implant-associated Anaplastic Large Cell Lymphoma: Review and Multiparametric Imaging Paradigms. ⁶¹	Sharma B...El-Sharkawi D	32302264	2020
18	European Attitudes and Outcomes Regarding Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Multinational Survey. ⁶¹	Villarroya-Marquina I...Lee GK	32367324	2020
19	Breast implant-associated anaplastic large cell lymphoma: emotional impact and guidelines for psychological support. ⁶¹	Oliveri S...Pravettoni G	32232699	2020
20	Molecular profiling reveals a hypoxia signature in breast implant-associated anaplastic large cell lymphoma. ⁶¹	Oishi N...Feldman AL	32414854	2020
21	Optimizing Breast Pocket Irrigation: The Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Era. ⁶¹	Culbertson EJ...Adams WP	31501857	2020
22	Breast implant-associated anaplastic large cell lymphoma and the obligation of insurance providers. ⁶¹	Teven CM...Pockaj BA	32436271	2020
23	Breast implant-associated anaplastic large-cell lymphoma: first case detected in a Japanese breast cancer patient. ⁶¹	Ohishi Y...Minabe T	32095988	2020
24	Advances and current concepts in reconstructive surgery for breast cancer. ⁶¹	Coombs DM...Schwarz GS	32522379	2020
25	Incidence of Anaplastic Large Cell Lymphoma and Breast-Implant-Associated Lymphoma-An Analysis of a Certified Tumor Registry over 17 Years. ⁶¹	Prantl L...Biermann N	32344893	2020
26	Online Patient Resources for Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Readability Analysis. ⁶¹	Cheah MA...Cooney CM	31977528	2020
27	[An algorithmic approach for diagnosis and treatment of breast implant-associated anaplastic large cell lymphoma]. ⁶¹	Moellhoff N...Giunta RE	32259859	2020
28	Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): An Open Wound. ⁶¹	de Faria Castro Fleury E	31932890	2020
29	Best Practices Guideline for the Pathologic Diagnosis of Breast Implant-Associated Anaplastic Large-Cell Lymphoma. ⁶¹	Jaffe ES...Yoon SW	32045544	2020
30	The Emerging Crisis of Stakeholders in Implant-based Augmentation Mammaplasty in Korea. ⁶¹	Kim JH...Park HK	32301294	2020
31	Why Do We Need Anatomical Implants? the Science and Rationale for Maintaining Their Availability and Use in Breast Surgery. ⁶¹	Montemurro P...Heden P	31897627	2020
32	Public Interest in Textured Breast Implants Recall: A Google Trends Analysis. ⁶¹	Dayani F...Nazerali RS	32356152	2020
33	Reconsideration of the first recognition of breast implant-associated anaplastic large cell lymphoma: A critical review of the literature. ⁶¹	Lyapichev KA...Miranda RN	32028122	2020
34	Breast magnetic resonance imaging (BMRI) in the diagnosis of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL): Findings beyond late seroma. ⁶¹	Fleury EFC	32166789	2020
35	B-cell lymphomas associated with breast implants: Report of three cases and review of the literature. ⁶¹	Evans MG...Pinter-Brown LC	32315816	2020
36	Breast Implant-associated Anaplastic Large Cell Lymphoma Affecting a Neosubpectoral Pocket. ⁶¹	Hobson G...Sherbert D	32257718	2020
37	Identifying patients at risk of breast implant-associated anaplastic large cell lymphoma: A commentary. ⁶¹	Hill WF...Temple-Oberle C	32223041	2020
38	Breast implant-associated anaplastic large cell lymphoma: A comprehensive review. ⁶¹	Marra A...Curigliano G	31958739	2020
39	Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and the Textured Breast Implant Crisis. ⁶¹	K Groth A...Graf R	31624894	2020
40	Current Risk Estimate of Breast Implant-Associated Anaplastic Large Cell Lymphoma in Textured Breast Implants. ⁶¹	Sheena Y...Ramakrishnan V	31985673	2020
41	Evaluating the Necessity of Capsulectomy in Cases of Textured Breast Implant Replacement. ⁶¹	Swanson E	32102001	2020
42	Capsular synovial metaplasia mimicking radiographic features of implant-associated anaplastic lymphoma. ⁶¹	Linden O...Strachowski L	31816541	2020
43	Persistent Extranodal Marginal Zone Lymphoma (MZL) in the Capsule of a Re-explanted Silicone Prosthesis Following Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL). ⁶¹	Har-Shai L...Preis M	32043335	2020
44	Commentary on: Breast Implant-Associated Anaplastic Large Cell Lymphoma in Australia: A Longitudinal Study of Implant and Other Related Risk Factors. ⁶¹	Turner SD	32011676	2020
45	Breast implant-associated anaplastic large cell lymphoma: A rare case report of lymphoma in the form of a pericapsular solid formation. ⁶¹	Gardani M...Palli D	31489733	2020
46	Invited Discussion on: Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and the Textured Implant Crisis. ⁶¹	Souto LRM	31654091	2020
47	[A historical view of breast implants: Controversy on silicones and breast implant associated -anaplastic large cell lymphoma]. ⁶¹	Rivera JC	31331682	2020
48	Cell of Origin and Immunologic Events in the Pathogenesis of Breast Implant-Associated Anaplastic Large-Cell Lymphoma. ⁶¹	Turner SD...Kadin ME	31610171	2020
49	Breast implant-associated anaplastic large cell lymphoma and effusions: A review with emphasis on the role of cytopathology. ⁶¹	Julien LA...Auger M	31899606	2020
50	Commentary on: Validation of a CD30 Enzyme-Linked Immunosorbant Assay for the Rapid Detection of Breast Implant-Associated Anaplastic Large Cell Lymphoma. ⁶¹	Turner SD...Wright P	30789658	2020

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Genes for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Genes related to Breast Implant-Associated Anaplastic Large Cell Lymphoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	JAK1	Janus Kinase 1	Protein Coding	12.73	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	12.58	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	TP53	Tumor Protein P53	Protein Coding	11.39	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	DNMT3A	DNA Methyltransferase 3 Alpha	Protein Coding	10.85	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	IL13	Interleukin 13	Protein Coding	10.77	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	7.99	DISEASES inferred ¹⁵
7	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	7.16	DISEASES inferred ¹⁵
8	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	7.15	DISEASES inferred ¹⁵ ¹⁵
9	DUSP22	Dual Specificity Phosphatase 22	Protein Coding	6.24	DISEASES inferred ¹⁵
10	TIA1	TIA1 Cytotoxic Granule Associated RNA Binding Protein	Protein Coding	5.8	DISEASES inferred ¹⁵

Sources

Variations for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Sources

Expression for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Search GEO for disease gene expression data for Breast Implant-Associated Anaplastic Large Cell Lymphoma.

Sources

Pathways for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Pathways related to Breast Implant-Associated Anaplastic Large Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 19)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.42	TP53 TNFRSF8 STAT3 JAK1 IL13 CCR6
2	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.35	TP53 TNFRSF8 STAT3 IL13 CCR6 ALK
3	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.07	TP53 TNFRSF8 STAT3 JAK1 IL13
4	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	12.65	TP53 TNFRSF8 STAT3 JAK1 IL13 CCR6
5	Pathways in cancer ³⁶	12.44	TP53 STAT3 JAK1 IL13 ALK
6	Development IGF-1 receptor signaling ²² Show member pathways IL-4 Signaling Pathway ¹ Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	12.14	TP53 STAT3 JAK1
7	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.08	STAT3 JAK1 IL13
8	Viral carcinogenesis ³⁶	12.01	TP53 STAT3 JAK1
9	G-protein signaling Ras family GTPases in kinase cascades (scheme) ²² Show member pathways Activation of the AP-1 family of transcription factors ⁶⁵ Immune response Oncostatin M signaling via MAPK in human cells ²² MAPK Cascade ¹ Nanoparticle-mediated activation of receptor signaling ¹ Oncostatin M Signaling Pathway ¹	11.99	TP53 STAT3 JAK1
10	Colorectal Cancer Metastasis ⁶³	11.87	TP53 STAT3 JAK1
11	MAPK Pathway ⁷⁰ Show member pathways Toll-like Receptor Pathway ⁷⁰	11.7	TP53 STAT3 IL13
12	Hepatitis C and Hepatocellular Carcinoma ¹	11.25	TP53 STAT3 JAK1
13	Interleukin-10 signaling ⁶⁵	11.12	STAT3 JAK1 IL13
14	Immune response_IL-6 signaling pathway ²²	11.09	STAT3 JAK1
15	IL10 Signaling Pathway ⁶⁶	11.01	STAT3 JAK1
16	Interleukin-4 and 13 signaling ⁶⁵	10.98	TP53 STAT3 JAK1 IL13
17	IL12 signaling mediated by STAT4 ¹	10.96	STAT3 IL13
18	IL-10 Pathway ⁶³	10.88	TIA1 STAT3 JAK1
19	Immune response_Oncostatin M signaling via JAK-Stat in human cells ²²	10.74	STAT3 JAK1

Sources

GO Terms for Breast Implant-Associated Anaplastic Large Cell Lymphoma

Biological processes related to Breast Implant-Associated Anaplastic Large Cell Lymphoma according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	response to ethanol	GO:0045471	9.58	STAT3 IL13 DNMT3A
2	response to antibiotic	GO:0046677	9.49	TP53 JAK1
3	interleukin-7-mediated signaling pathway	GO:0038111	9.48	STAT3 JAK1
4	interleukin-6-mediated signaling pathway	GO:0070102	9.46	STAT3 JAK1
5	interleukin-15-mediated signaling pathway	GO:0035723	9.43	STAT3 JAK1
6	interleukin-35-mediated signaling pathway	GO:0070757	9.37	STAT3 JAK1
7	interleukin-27-mediated signaling pathway	GO:0070106	9.32	STAT3 JAK1
8	interleukin-9-mediated signaling pathway	GO:0038113	9.26	STAT3 JAK1
9	cytokine-mediated signaling pathway	GO:0019221	9.26	TP53 STAT3 JAK1 IL13
10	interleukin-21-mediated signaling pathway	GO:0038114	9.16	STAT3 JAK1
11	regulation of cell proliferation	GO:0042127	8.92	TP53 STAT3 DUSP22 ALK

Molecular functions related to Breast Implant-Associated Anaplastic Large Cell Lymphoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein phosphatase binding	GO:0019903	9.13	TP53 STAT3 JAK1
2	CCR5 chemokine receptor binding	GO:0031730	8.62	STAT3 JAK1

Sources

Sources for Breast Implant-Associated Anaplastic Large Cell Lymphoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

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¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

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⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

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⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia