MCID: BRS055
MIFTS: 31

Breast Intraductal Proliferative Lesion

Categories: Cancer diseases

Aliases & Classifications for Breast Intraductal Proliferative Lesion

MalaCards integrated aliases for Breast Intraductal Proliferative Lesion:

Name: Breast Intraductal Proliferative Lesion 12 15
Intraductal Proliferative Lesion of the Breast 74
Intraductal Proliferative Lesion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6839
NCIt 51 C27942
UMLS 74 C1334631

Summaries for Breast Intraductal Proliferative Lesion

Disease Ontology : 12 An intraductal breast neoplasm that is characterized by an increase in the number of cells perpendicular to the basement membrane resulting in total alteration and distension of the normal unit structure of the breast. It is confined to the duct-lobular system, originates from the terminal duct-lobular unit and displays different cytological and architectural patterns of proliferation.

MalaCards based summary : Breast Intraductal Proliferative Lesion, also known as intraductal proliferative lesion of the breast, is related to in situ carcinoma and ductal carcinoma in situ. An important gene associated with Breast Intraductal Proliferative Lesion is EGFR (Epidermal Growth Factor Receptor), and among its related pathways/superpathways are ErbB signaling pathway and Immune response IL-23 signaling pathway. The drugs Tamoxifen and Fenretinide have been mentioned in the context of this disorder. Affiliated tissues include breast and bone, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Related Diseases for Breast Intraductal Proliferative Lesion

Diseases related to Breast Intraductal Proliferative Lesion via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 in situ carcinoma 30.0 EGFR ERBB2
2 ductal carcinoma in situ 30.0 EGFR ERBB2
3 flat ductal epithelial atypia 11.5
4 breast cancer 9.9
5 progesterone-receptor negative breast cancer 9.9 EGFR ERBB2
6 breast scirrhous carcinoma 9.9 EGFR ERBB2
7 breast squamous cell carcinoma 9.9 EGFR ERBB2
8 squamous cell carcinoma 9.9 EGFR ERBB2
9 microglandular adenosis 9.9 EGFR ERBB2
10 inflammatory breast carcinoma 9.9 EGFR ERBB2
11 luminal breast carcinoma 9.9 EGFR ERBB2
12 acneiform dermatitis 9.9 EGFR ERBB2
13 lipid-rich carcinoma 9.9 EGFR ERBB2
14 mucinous lung adenocarcinoma 9.9 EGFR ERBB2
15 adenocarcinoma 9.9 EGFR ERBB2
16 hidradenocarcinoma 9.9 EGFR ERBB2
17 mammary paget's disease 9.9 EGFR ERBB2
18 gallbladder adenocarcinoma 9.9 EGFR ERBB2
19 primary peritoneal carcinoma 9.9 EGFR ERBB2
20 adenosquamous lung carcinoma 9.9 EGFR ERBB2
21 pre-malignant neoplasm 9.9 EGFR ERBB2
22 exanthem 9.9 EGFR ERBB2
23 breast carcinoma in situ 9.9 EGFR ERBB2
24 esophageal disease 9.9 EGFR ERBB2
25 estrogen-receptor positive breast cancer 9.9 EGFR ERBB2
26 stomach disease 9.9 EGFR ERBB2
27 female reproductive system disease 9.9 EGFR ERBB2
28 reproductive system disease 9.9 EGFR ERBB2
29 mucoepidermoid carcinoma 9.9 EGFR ERBB2
30 respiratory system cancer 9.9 EGFR ERBB2
31 endometrial adenocarcinoma 9.9 EGFR ERBB2
32 uterine carcinosarcoma 9.9 EGFR ERBB2
33 breast ductal carcinoma 9.9 EGFR ERBB2
34 oral cavity cancer 9.9 EGFR ERBB2
35 gastrointestinal system cancer 9.9 EGFR ERBB2
36 endocrine gland cancer 9.8 EGFR ERBB2
37 transitional cell carcinoma 9.8 EGFR ERBB2
38 breast adenocarcinoma 9.8 EGFR ERBB2
39 gastrointestinal system disease 9.8 EGFR ERBB2
40 pancreas adenocarcinoma 9.8 EGFR ERBB2
41 gallbladder cancer 9.8 EGFR ERBB2
42 adamantinoma of long bones 9.8 EGFR ERBB2
43 cholangiocarcinoma 9.8 EGFR ERBB2
44 glioblastoma multiforme 9.8 EGFR ERBB2
45 glioblastoma 9.8 EGFR ERBB2
46 squamous cell carcinoma, head and neck 9.7 EGFR ERBB2
47 large intestine cancer 9.7 EGFR ERBB2
48 glioma 9.7 EGFR ERBB2
49 gastric adenocarcinoma 9.6 EGFR ERBB2
50 lung cancer susceptibility 3 9.5 EGFR ERBB2

Graphical network of the top 20 diseases related to Breast Intraductal Proliferative Lesion:



Diseases related to Breast Intraductal Proliferative Lesion

Symptoms & Phenotypes for Breast Intraductal Proliferative Lesion

GenomeRNAi Phenotypes related to Breast Intraductal Proliferative Lesion according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 9.13 EGFR ERBB2
2 Decreased viability with paclitaxel GR00179-A-3 9.13 EGFR
3 Increased cell viability after pRB stimulation GR00230-A-1 8.62 EGFR ERBB2

Drugs & Therapeutics for Breast Intraductal Proliferative Lesion

Drugs for Breast Intraductal Proliferative Lesion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamoxifen Approved Phase 3 10540-29-1 2733526
2
Fenretinide Investigational Phase 3 65646-68-6
3 Bone Density Conservation Agents Phase 3
4 Estrogen Receptor Antagonists Phase 3
5 Estrogen Antagonists Phase 3
6 Hormones Phase 3
7 Antineoplastic Agents, Hormonal Phase 3
8 Hormone Antagonists Phase 3
9 Selective Estrogen Receptor Modulators Phase 3
10 Estrogens Phase 3
11 Estrogen Receptor Modulators Phase 3
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trial of Low Dose Tamoxifen in Women With Breast Intraepithelial Neoplasia Active, not recruiting NCT01357772 Phase 3 Tamoxifen;placebo
2 Fenretinide in Healthy Young Women at Genetic and Familial Risk Terminated NCT01479192 Phase 3 Fenretinide
3 Optical Coherence Tomography in Tissue Samples From Women Undergoing Mastectomy for the Treatment or Prevention of Breast Ductal Intraepithelial Neoplasia Completed NCT00807404 Not Applicable

Search NIH Clinical Center for Breast Intraductal Proliferative Lesion

Genetic Tests for Breast Intraductal Proliferative Lesion

Anatomical Context for Breast Intraductal Proliferative Lesion

MalaCards organs/tissues related to Breast Intraductal Proliferative Lesion:

42
Breast, Bone

Publications for Breast Intraductal Proliferative Lesion

Variations for Breast Intraductal Proliferative Lesion

Expression for Breast Intraductal Proliferative Lesion

Search GEO for disease gene expression data for Breast Intraductal Proliferative Lesion.

Pathways for Breast Intraductal Proliferative Lesion

Pathways related to Breast Intraductal Proliferative Lesion according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.19 EGFR ERBB2
2
Show member pathways
12.18 EGFR ERBB2
3 12.12 EGFR ERBB2
4
Show member pathways
12.1 EGFR ERBB2
5
Show member pathways
12.04 EGFR ERBB2
6
Show member pathways
11.94 EGFR ERBB2
7
Show member pathways
11.91 EGFR ERBB2
8 11.9 EGFR ERBB2
9 11.87 EGFR ERBB2
10
Show member pathways
11.81 EGFR ERBB2
11 11.79 EGFR ERBB2
12
Show member pathways
11.75 EGFR ERBB2
13 11.74 EGFR ERBB2
14 11.73 EGFR ERBB2
15
Show member pathways
11.71 EGFR ERBB2
16
Show member pathways
11.65 EGFR ERBB2
17
Show member pathways
11.62 EGFR ERBB2
18
Show member pathways
11.53 EGFR ERBB2
19 11.48 EGFR ERBB2
20
Show member pathways
11.43 EGFR ERBB2
21 11.34 EGFR ERBB2
22 11.3 EGFR ERBB2
23 11.26 EGFR ERBB2
24
Show member pathways
11.2 EGFR ERBB2
25 11.2 EGFR ERBB2
26 11.13 EGFR ERBB2
27 11.01 EGFR ERBB2
28 11.01 EGFR ERBB2
29 10.81 EGFR ERBB2
30 10.45 EGFR ERBB2
31 10.1 EGFR ERBB2

GO Terms for Breast Intraductal Proliferative Lesion

Cellular components related to Breast Intraductal Proliferative Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.32 EGFR ERBB2
2 endosome membrane GO:0010008 9.26 EGFR ERBB2
3 receptor complex GO:0043235 9.16 EGFR ERBB2
4 basolateral plasma membrane GO:0016323 8.96 EGFR ERBB2
5 basal plasma membrane GO:0009925 8.62 EGFR ERBB2

Biological processes related to Breast Intraductal Proliferative Lesion according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.6 EGFR ERBB2
2 cell surface receptor signaling pathway GO:0007166 9.59 EGFR ERBB2
3 MAPK cascade GO:0000165 9.58 EGFR ERBB2
4 positive regulation of protein phosphorylation GO:0001934 9.57 EGFR ERBB2
5 peptidyl-tyrosine phosphorylation GO:0018108 9.56 EGFR ERBB2
6 protein autophosphorylation GO:0046777 9.55 EGFR ERBB2
7 positive regulation of protein kinase B signaling GO:0051897 9.54 EGFR ERBB2
8 phosphatidylinositol phosphorylation GO:0046854 9.51 EGFR ERBB2
9 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.49 EGFR ERBB2
10 wound healing GO:0042060 9.48 EGFR ERBB2
11 positive regulation of cell growth GO:0030307 9.46 EGFR ERBB2
12 positive regulation of epithelial cell proliferation GO:0050679 9.43 EGFR ERBB2
13 positive regulation of MAP kinase activity GO:0043406 9.4 EGFR ERBB2
14 cellular response to growth factor stimulus GO:0071363 9.37 EGFR ERBB2
15 cellular response to epidermal growth factor stimulus GO:0071364 9.32 EGFR ERBB2
16 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.28 EGFR
17 ERBB2 signaling pathway GO:0038128 9.26 EGFR ERBB2
18 positive regulation of MAPK cascade GO:0043410 9.22 ERBB2
19 regulation of cell motility GO:2000145 9.16 EGFR ERBB2
20 regulation of ERK1 and ERK2 cascade GO:0070372 8.96 EGFR ERBB2
21 negative regulation of ERBB signaling pathway GO:1901185 8.62 EGFR ERBB2

Molecular functions related to Breast Intraductal Proliferative Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.37 EGFR ERBB2
2 protein tyrosine kinase activity GO:0004713 9.32 EGFR ERBB2
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.26 EGFR ERBB2
4 protein phosphatase binding GO:0019903 9.16 EGFR ERBB2
5 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.96 EGFR ERBB2
6 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 EGFR ERBB2

Sources for Breast Intraductal Proliferative Lesion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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