Breast Juvenile Papillomatosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Breast Juvenile Papillomatosis

MalaCards integrated aliases for Breast Juvenile Papillomatosis:

Name: Breast Juvenile Papillomatosis ¹² ¹⁵

Juvenile Papillomatosis of the Breast ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6641

NCIt ⁴⁹ C9503

UMLS ⁷¹ C1334303

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Summaries for Breast Juvenile Papillomatosis

Disease Ontology : ¹² A breast papillomatosis that is characterized by a discrete, muticystic breast lesion that occurs at a median age of 20 years.

MalaCards based summary : Breast Juvenile Papillomatosis, also known as juvenile papillomatosis of the breast, is related to breast papillomatosis and breast fibroadenoma. An important gene associated with Breast Juvenile Papillomatosis is OXT (Oxytocin/Neurophysin I Prepropeptide), and among its related pathways/superpathways are Chks in Checkpoint Regulation and Glioma. Affiliated tissues include breast, ovary and smooth muscle, and related phenotypes are Decreased viability in esophageal squamous lineage and Decreased viability with cisplatin

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Related Diseases for Breast Juvenile Papillomatosis

Diseases in the Breast Papillomatosis family:

Breast Juvenile Papillomatosis

Diseases related to Breast Juvenile Papillomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)

#	Related Disease	Score	Top Affiliating Genes
1	breast papillomatosis	30.9	OXT ERBB2
2	breast fibroadenoma	28.6	PGR ESR1 ERBB2 BRCA1
3	hypertrophy of breast	28.0	PGR ESR1 ERBB2 BRCA2 BRCA1
4	lobular neoplasia	28.0	PGR ESR1 ERBB2 BRCA2 BRCA1
5	in situ carcinoma	28.0	PGR ESR1 ERBB2 BRCA2 BRCA1
6	breast disease	28.0	PGR ESR1 ERBB2 BRCA2 BRCA1
7	breast cancer	10.4
8	papilloma	10.4
9	postmenopausal atrophic vaginitis	10.1	OXT ESR1
10	mild pre-eclampsia	10.1	OXT ESR1
11	scirrhous adenocarcinoma	10.1	PGR ERBB2
12	lipid-rich breast carcinoma	10.0	PGR ERBB2
13	carcinosarcoma	10.0	PGR ERBB2
14	apocrine adenosis of breast	10.0	PGR ERBB2
15	breast adenoid cystic carcinoma	10.0	PGR ERBB2
16	breast mucinous carcinoma	10.0	PGR ERBB2
17	linitis plastica	10.0	PGR ERBB2
18	bartholin's gland adenoid cystic carcinoma	10.0	PGR ESR1
19	chronic tympanitis	10.0	PGR ESR1
20	bartholin's gland adenoma	10.0	PGR ESR1
21	granulomatous endometritis	10.0	PGR ESR1
22	neurofibromatosis, type iv, of riccardi	10.0
23	noonan syndrome 1	10.0
24	squamous cell papilloma	10.0
25	pseudo-turner syndrome	10.0
26	bartholin's gland benign neoplasm	10.0	PGR ESR1
27	apocrine sweat gland neoplasm	10.0	PGR ERBB2
28	vestibular gland benign neoplasm	10.0	PGR ESR1
29	lung leiomyoma	10.0	PGR ESR1
30	vulvar syringoma	10.0	PGR ESR1
31	trigonitis	10.0	PGR ESR1
32	vagina leiomyosarcoma	10.0	PGR ESR1
33	adult type testicular granulosa cell tumor	10.0	PGR ESR1
34	ovarian seromucinous carcinoma	10.0	PGR ESR1
35	breast leiomyoma	10.0	PGR ESR1
36	gastric diffuse adenocarcinoma	10.0	PGR ERBB2
37	postpartum depression	10.0	OXT ESR1
38	intravenous leiomyomatosis	10.0	PGR ESR1
39	leiomyomatosis	10.0	PGR ESR1
40	liver leiomyoma	10.0	PGR ESR1
41	cervical adenocarcinoma	10.0	ESR1 ERBB2
42	mammographic density	10.0	PGR ESR1
43	vulvar leiomyoma	10.0	PGR ESR1
44	bizarre leiomyoma	10.0	PGR ESR1
45	vulvar disease	10.0	PGR ERBB2
46	vaginal endometrial stromal sarcoma	10.0	PGR ESR1
47	vagina sarcoma	10.0	PGR ESR1
48	progesterone resistance	10.0	PGR ESR1
49	cervical mucinous adenocarcinoma	10.0	PGR ESR1
50	adenomyoma	10.0	PGR ESR1

Graphical network of the top 20 diseases related to Breast Juvenile Papillomatosis:

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Symptoms & Phenotypes for Breast Juvenile Papillomatosis

GenomeRNAi Phenotypes related to Breast Juvenile Papillomatosis according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability in esophageal squamous lineage	GR00235-A	9.55	BRCA1 BRCA2 ERBB2 ESR1 PGR
2	Decreased viability with cisplatin	GR00101-A-4	8.96	BRCA1 BRCA2
3	Synthetic lethal with cisplatin	GR00101-A-1	8.62	BRCA1 BRCA2

MGI Mouse Phenotypes related to Breast Juvenile Papillomatosis:

⁴⁵ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10	BRCA1 BRCA2 ERBB2 ESR1 OXT PGR
2	endocrine/exocrine gland	MP:0005379	9.93	BRCA1 BRCA2 ERBB2 ESR1 OXT PGR
3	cardiovascular system	MP:0005385	9.91	BRCA1 ERBB2 ESR1 OXT PGR
4	homeostasis/metabolism	MP:0005376	9.91	BRCA1 BRCA2 ERBB2 ESR1 OXT PGR
5	digestive/alimentary	MP:0005381	9.89	BRCA1 BRCA2 ERBB2 ESR1 OXT
6	embryo	MP:0005380	9.88	BRCA1 BRCA2 ERBB2 ESR1 PGR
7	integument	MP:0010771	9.88	BRCA1 BRCA2 ERBB2 ESR1 OXT PGR
8	mortality/aging	MP:0010768	9.8	BRCA1 BRCA2 ERBB2 ESR1 OXT PGR
9	limbs/digits/tail	MP:0005371	9.77	BRCA1 BRCA2 ERBB2 ESR1 PGR
10	neoplasm	MP:0002006	9.65	BRCA1 BRCA2 ERBB2 ESR1 PGR
11	normal	MP:0002873	9.55	BRCA1 BRCA2 ERBB2 ESR1 PGR
12	reproductive system	MP:0005389	9.43	BRCA1 BRCA2 ERBB2 ESR1 OXT PGR
13	skeleton	MP:0005390	9.02	BRCA1 BRCA2 ERBB2 ESR1 PGR

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Drugs & Therapeutics for Breast Juvenile Papillomatosis

Search Clinical Trials , NIH Clinical Center for Breast Juvenile Papillomatosis

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Genetic Tests for Breast Juvenile Papillomatosis

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Anatomical Context for Breast Juvenile Papillomatosis

MalaCards organs/tissues related to Breast Juvenile Papillomatosis:

⁴⁰

Breast, Ovary, Smooth Muscle, Liver, Lung, Prostate, Cervix

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Publications for Breast Juvenile Papillomatosis

Articles related to Breast Juvenile Papillomatosis:

(show all 26)

#	Title	Authors	PMID	Year
1	Juvenile Papillomatosis: A Case Report. ⁶¹	Vandeweerd V...Neven P	31001616	2019
2	Giant juvenile papillomatosis of the breast in a Nigerian girl. ⁶¹	Olarinoye-Akorede SA...Kajogbola GA	30567257	2018
3	Juvenile Papillomatosis of the Breast in a Pre-Pubertal Girl: An Uncommon Diagnosis. ⁶¹	Kafadar MT...Tarini EZ	29322120	2018
4	Juvenile Papillomatosis (Swiss-Cheese Disease) of Breast in an Adult Male With Sequential Diagnoses of Ipsilateral Intraductal, Invasive, and Widely Metastatic Carcinoma: A Case Report and Review of the Disease in Males. ⁶¹	Viswanathan K...Hoda SA	28420303	2017
5	Magnetic resonance imaging findings of breast juvenile papillomatosis. ⁶¹	Durur-Subasi I...Gundogdu C	23475601	2013
6	Juvenile papillomatosis of the breast in young male: a case report. ⁶¹	Sanguinetti A...Avenia N	22018260	2011
7	Juvenile papillomatosis of the breast associated with neurofibromatosis 1. ⁶¹	Tan TY...Chow CW	16883593	2007
8	[Juvenille papillomatosis]. ⁶¹	Fellah L...Leconte I	16484940	2006
9	Juvenile papillomatosis of the breast in a male infant with Noonan syndrome, café au lait spots, and family history of breast carcinoma. ⁶¹	Pacilli M...Pierro A	15700254	2005
10	[Juvenile papillomatosis of the breast]. ⁶¹	Noccioli P...Cianchetti E	12870277	2003
11	Juvenile papillomatosis of the breast in a 9-year-old girl. ⁶¹	Hsieh SC...Chou JM	11315290	2001
12	A case of breast cancer associated with juvenile papillomatosis of the male breast. ⁶¹	Munitiz V...Parrilla P	11078621	2000
13	Juvenile papillomatosis of the breast in male infants: two case reports. ⁶¹	Rice HE...Azizkhan RG	10663852	2000
14	[Breast malignancy in girls]. ⁶¹	Rzepka-Gorska I...Blogowska A	10462972	1999
15	A Case of Multiple Juvenile Papillomatosis of the Breast and Its Immunohistochemical Pathology. ⁶¹	Nio Y...Tamura K	11091647	1998
16	Juvenile papillomatosis of the breast (Swiss cheese disease) ⁶¹	Hidalgo F...Marhuenda A	9275926	1997
17	Giant juvenile papillomatosis of the breast: report of two cases. ⁶¹	Farid MK...Visveswara RN	9185400	1997
18	Case report: MR imaging of juvenile papillomatosis of the breast. ⁶¹	Mussurakis S...Turnbull LW	8983594	1996
19	Juvenile papillomatosis of the breast. ⁶¹	Talisman R...Pfeffermann R	8103370	1993
20	Juvenile papillomatosis of the breast. A multidisciplinary study. ⁶¹	Taffurelli M...Marrano D	2014142	1991
21	Juvenile papillomatosis of the breast. A follow-up study of 41 patients having biopsies before 1979. ⁶¹	Rosen PP...Kimmel M	2158224	1990
22	The continuing evolution of our understanding of juvenile papillomatosis of the breast. ⁶¹	Dehner LP	2158228	1990
23	Juvenile papillomatosis of the breast: sonographic appearance. ⁶¹	Kersschot EA...Van Hoorde P	3055027	1988
24	[Intraductal juvenile papillomatosis of the breast]. ⁶¹	Schulz HJ...Winzer KJ	3617975	1987
25	Juvenile papillomatosis of the breast and family history of breast carcinoma. ⁶¹	Rosen PP...Beattie EJ	7074576	1982
26	Juvenile papillomatosis (Swiss cheese disease) of the breast. ⁶¹	Rosen PP...DePalo A	7361994	1980

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Genes for Breast Juvenile Papillomatosis

Genes related to Breast Juvenile Papillomatosis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	OXT	Oxytocin/Neurophysin I Prepropeptide	Protein Coding	4.21	DISEASES inferred ¹⁵
2	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	3.84	DISEASES inferred ¹⁵
3	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	3.64	DISEASES inferred ¹⁵
4	PGR	Progesterone Receptor	Protein Coding	3.53	DISEASES inferred ¹⁵
5	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	3.41	DISEASES inferred ¹⁵
6	ESR1	Estrogen Receptor 1	Protein Coding	3.25	DISEASES inferred ¹⁵

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Variations for Breast Juvenile Papillomatosis

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Expression for Breast Juvenile Papillomatosis

Search GEO for disease gene expression data for Breast Juvenile Papillomatosis.

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Pathways for Breast Juvenile Papillomatosis

Pathways related to Breast Juvenile Papillomatosis according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	Chks in Checkpoint Regulation ⁶³ Show member pathways DNA Repair Mechanisms ⁶³ Estrogen-mediated S-Phase Entry ⁶³ G2-M Phase Transition ⁶³ Parkinson's Disease Pathway ⁶³ SREBP Proteolysis ⁶³	12.26	ESR1 BRCA2 BRCA1
2	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	11.85	ESR1 ERBB2 BRCA2 BRCA1
3	Cell cycle Role of SCF complex in cell cycle regulation ²² Show member pathways Cell cycle ESR1 regulation of G1/S transition ²² Cell cycle Regulation of G1/S transition (part 1) ²² Immune response MIF-JAB1 signaling ²²	11.74	PGR ESR1 BRCA1
4	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	11.69	PGR ESR1 ERBB2 BRCA2 BRCA1
5	Integrated Breast Cancer Pathway ¹	11.62	ESR1 BRCA2 BRCA1
6	Signaling by ERBB4 ⁶⁵ Show member pathways Downregulation of ERBB4 signaling ⁶⁵ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁵	11.37	PGR ESR1 ERBB2
7	Platinum drug resistance ³⁶	11.36	ERBB2 BRCA1
8	Pathways Affected in Adenoid Cystic Carcinoma ¹	11.28	ERBB2 BRCA1
9	Validated targets of C-MYC transcriptional repression ¹	11.22	ERBB2 BRCA1
10	FOXA1 transcription factor network ¹ Show member pathways FOXA transcription factor networks ¹	11.07	ESR1 BRCA1
11	FOXM1 transcription factor network ¹	10.94	ESR1 BRCA2

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GO Terms for Breast Juvenile Papillomatosis

Cellular components related to Breast Juvenile Papillomatosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lateral element	GO:0000800	8.62	BRCA2 BRCA1

Biological processes related to Breast Juvenile Papillomatosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	double-strand break repair	GO:0006302	9.37	BRCA2 BRCA1
2	response to estrogen	GO:0043627	9.32	ESR1 BRCA1
3	steroid hormone mediated signaling pathway	GO:0043401	9.26	PGR ESR1
4	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.16	BRCA2 BRCA1
5	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	8.96	BRCA2 BRCA1
6	chordate embryonic development	GO:0043009	8.62	BRCA2 BRCA1

Molecular functions related to Breast Juvenile Papillomatosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	enzyme binding	GO:0019899	9.43	PGR ESR1 BRCA1
2	steroid hormone receptor activity	GO:0003707	9.32	PGR ESR1
3	nuclear receptor activity	GO:0004879	9.16	PGR ESR1
4	identical protein binding	GO:0042802	9.02	PGR ESR1 ERBB2 BRCA2 BRCA1
5	steroid binding	GO:0005496	8.96	PGR ESR1

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Sources for Breast Juvenile Papillomatosis

¹ BioSystems

² BitterDB

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²⁰ GeneAnalytics

²¹ GeneCards

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²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

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²⁷ GEO DataSets

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⁴⁰ MalaCards

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⁵⁴ Novoseek

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⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

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⁶¹ PubMed

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⁶⁷ SNOMED-CT

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⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

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⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia