Breast Juvenile Papillomatosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Breast Juvenile Papillomatosis

MalaCards integrated aliases for Breast Juvenile Papillomatosis:

Name: Breast Juvenile Papillomatosis ¹¹ ¹⁴

Juvenile Papillomatosis of the Breast ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:6641

NCIt ⁴⁹ C9503

SNOMED-CT ⁶⁸ 708518001

UMLS ⁷¹ C1334303

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Summaries for Breast Juvenile Papillomatosis

Disease Ontology: ¹¹ A breast benign neoplasm that is characterized by a discrete, muticystic breast lesion that occurs at a median age of 20 years.

MalaCards based summary: Breast Juvenile Papillomatosis, also known as juvenile papillomatosis of the breast, is related to lobular neoplasia and hypertrophy of breast. An important gene associated with Breast Juvenile Papillomatosis is NUP93 (Nucleoporin 93), and among its related pathways/superpathways are Disease and Signal Transduction. Affiliated tissues include breast, and related phenotypes are Decreased viability and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Breast Juvenile Papillomatosis

Diseases related to Breast Juvenile Papillomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)

#	Related Disease	Score	Top Affiliating Genes
1	lobular neoplasia	29.9	PTEN PIK3CA ERBB2
2	hypertrophy of breast	29.7	PTEN PIK3CA ERBB2 AKT1
3	papilloma	29.3	PTEN FGFR3 ERBB2 AKT1
4	breast cancer	10.5
5	breast disease	10.2
6	esophagus small cell carcinoma	10.2	PIK3CA ERBB2
7	skull base meningioma	10.2	PIK3CA AKT1
8	pregnancy adenoma	10.2	NTRK3 ETV6
9	immunodeficiency 14	10.2	PIK3CB PIK3CA AKT1
10	cellular congenital mesoblastic nephroma	10.2	NTRK3 ETV6
11	clear cell adenofibroma	10.2	PIK3CA ARID1A
12	breast secretory carcinoma	10.2	NTRK3 ETV6
13	adult fibrosarcoma	10.2	NTRK3 ETV6
14	lipofibromatosis-like neural tumor	10.2	NTRK3 ETV6
15	skull base cancer	10.2	PIK3CA AKT1
16	bartholin's gland adenoid cystic carcinoma	10.2	PIK3CA ARID1A
17	epithelial-myoepithelial carcinoma	10.1	NTRK3 ETV6
18	mixed lacrimal gland cancer	10.1	NTRK3 ETV6
19	apocrine adenocarcinoma	10.1	PIK3CA ERBB2
20	gastroesophageal adenocarcinoma	10.1	PIK3CA ERBB2 AKT1
21	anus cancer	10.1	PIK3CA ERBB2 AKT1
22	localized osteosarcoma	10.1	ERBB2 AKT1
23	neurofibromatosis, type i	10.1
24	noonan syndrome 1	10.1
25	palmoplantar keratoderma and congenital alopecia 2	10.1
26	neurofibromatosis-noonan syndrome	10.1
27	breast fibroadenoma	10.1
28	neurofibromatosis	10.1
29	mucinous adenocarcinoma	10.1	PIK3CA GNAS ERBB2
30	kidney fibrosarcoma	10.1	NTRK3 ETV6
31	intraductal breast benign neoplasm	10.1	PIK3CA ERBB2
32	parotid gland cancer	10.0	NTRK3 ETV6 ERBB2
33	lipid-rich carcinoma	10.0	NTRK3 ETV6 ERBB2
34	breast adenoid cystic carcinoma	10.0	NTRK3 ETV6 ERBB2
35	pleomorphic adenoma carcinoma	10.0	NTRK3 ETV6 ERBB2
36	breast abscess	10.0	OXT ERBB2
37	ovarian carcinosarcoma	10.0	PIK3CA ERBB2 ARID1A
38	exanthem	10.0	PIK3C2A ERBB2 AKT1
39	fallopian tube endometrioid adenocarcinoma	10.0	ERBB2 ARID1A
40	salivary gland disease	10.0	NTRK3 ETV6 ERBB2
41	anus basaloid carcinoma	10.0	PIK3CA KMT2C
42	salivary gland carcinoma	10.0	NTRK3 ETV6 ERBB2
43	acute anterolateral myocardial infarction	10.0	TAC1 PIK3C2A
44	intrahepatic cholangiocarcinoma	10.0	ERBB2 ARID1A AKT1
45	schimmelpenning-feuerstein-mims syndrome	10.0	PIK3CA GNAS FGFR3
46	hemimegalencephaly	10.0	PTEN PIK3CA
47	somatization disorder	9.9	TAC1 OXT
48	cutaneous ganglioneuroma	9.9	PIK3CA FGFR3
49	lung oat cell carcinoma	9.9	PTEN PIK3CA AKT1
50	thyroid tumor	9.9	PTEN PIK3CA AKT1

Graphical network of the top 20 diseases related to Breast Juvenile Papillomatosis:

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Symptoms & Phenotypes for Breast Juvenile Papillomatosis

GenomeRNAi Phenotypes related to Breast Juvenile Papillomatosis according to GeneCards Suite gene sharing:

²⁵ (show top 50) (show all 57)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-1	11.03	PIK3C2A PIK3CA
2	Decreased viability	GR00055-A-2	11.03	PIK3C2A PIK3CA
3	Decreased viability	GR00055-A-3	11.03	PIK3C2A
4	Decreased viability	GR00106-A-0	11.03	SMG1
5	Decreased viability	GR00221-A-1	11.03	AKT1 FGFR3 PIK3CB PIK3C2A PIK3CA SMG1
6	Decreased viability	GR00221-A-2	11.03	AKT1 FGFR3 NTRK3 PIK3C2A PIK3CA
7	Decreased viability	GR00221-A-3	11.03	AKT1 ERBB2 FGFR3 PIK3CB
8	Decreased viability	GR00221-A-4	11.03	AKT1 ERBB2 PIK3CB NTRK3 PIK3C2A PIK3CA
9	Decreased viability	GR00240-S-1	11.03	PIK3C2A
10	Decreased viability	GR00249-S	11.03	AKT1 FGFR3 PIK3C2A
11	Decreased viability	GR00342-S-1	11.03	PIK3C2A SMG1
12	Decreased viability	GR00342-S-2	11.03	PIK3C2A
13	Decreased viability	GR00342-S-3	11.03	PIK3C2A SMG1
14	Decreased viability	GR00381-A-1	11.03	PIK3CB
15	Decreased viability	GR00402-S-2	11.03	PIK3CB PIK3CA SMG1
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-10	10.69	FGFR3
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-109	10.69	NUP93
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-114	10.69	FGFR3
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-119	10.69	SMG1
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	10.69	FGFR3
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-123	10.69	SMG1
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-134	10.69	PIK3CB
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-136	10.69	NUP93
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-137	10.69	NTRK3
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-148	10.69	NTRK3
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-151	10.69	PTEN
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-152	10.69	NTRK3
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-153	10.69	SMG1
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	10.69	PTEN
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-160	10.69	SMG1
31	Increased shRNA abundance (Z-score > 2)	GR00366-A-161	10.69	ERBB2
32	Increased shRNA abundance (Z-score > 2)	GR00366-A-168	10.69	PTEN ERBB2
33	Increased shRNA abundance (Z-score > 2)	GR00366-A-174	10.69	NUP93
34	Increased shRNA abundance (Z-score > 2)	GR00366-A-207	10.69	ERBB2
35	Increased shRNA abundance (Z-score > 2)	GR00366-A-211	10.69	NUP93
36	Increased shRNA abundance (Z-score > 2)	GR00366-A-213	10.69	AKT1
37	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	10.69	PTEN
38	Increased shRNA abundance (Z-score > 2)	GR00366-A-215	10.69	SMG1
39	Increased shRNA abundance (Z-score > 2)	GR00366-A-22	10.69	PIK3CB
40	Increased shRNA abundance (Z-score > 2)	GR00366-A-30	10.69	NTRK3
41	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	10.69	ERBB2
42	Increased shRNA abundance (Z-score > 2)	GR00366-A-35	10.69	NUP93
43	Increased shRNA abundance (Z-score > 2)	GR00366-A-41	10.69	NTRK3
44	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	10.69	NTRK3 PTEN
45	Increased shRNA abundance (Z-score > 2)	GR00366-A-52	10.69	FGFR3 SMG1
46	Increased shRNA abundance (Z-score > 2)	GR00366-A-59	10.69	FGFR3
47	Increased shRNA abundance (Z-score > 2)	GR00366-A-6	10.69	NUP93
48	Increased shRNA abundance (Z-score > 2)	GR00366-A-60	10.69	AKT1 NTRK3 PIK3CA ERBB2 FGFR3 PIK3CB
49	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	10.69	PTEN ERBB2 FGFR3
50	Increased shRNA abundance (Z-score > 2)	GR00366-A-66	10.69	PTEN

MGI Mouse Phenotypes related to Breast Juvenile Papillomatosis:

⁴⁵ (show all 19)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.39	AKT1 ARID1A ERBB2 ETV6 FGFR3 GNAS
2	homeostasis/metabolism	MP:0005376	10.34	AKT1 ARID1A ERBB2 ETV6 FGFR3 GNAS
3	neoplasm	MP:0002006	10.32	AKT1 ARID1A ERBB2 ETV6 FGFR3 GNAS
4	nervous system	MP:0003631	10.3	AKT1 ARID1A ERBB2 FGF12 FGFR3 GNAS
5	cellular	MP:0005384	10.25	AKT1 ARID1A ERBB2 ETV6 FGFR3 GNAS
6	cardiovascular system	MP:0005385	10.25	AKT1 ARID1A ERBB2 ETV6 GNAS NTRK3
7	normal	MP:0002873	10.23	AKT1 ARID1A ERBB2 ETV6 FGFR3 GNAS
8	embryo	MP:0005380	10.22	AKT1 ARID1A ERBB2 ETV6 GNAS PIK3C2A
9	renal/urinary system	MP:0005367	10.15	ETV6 FGFR3 GNAS OXT PIK3C2A PTEN
10	endocrine/exocrine gland	MP:0005379	10.15	AKT1 ARID1A ERBB2 ETV6 GNAS OXT
11	no phenotypic analysis	MP:0003012	10.11	ARID1A ETV6 FGFR3 GNAS KMT2C NTRK3
12	adipose tissue	MP:0005375	10.08	AKT1 GNAS KMT2C OXT PIK3C2A PIK3CA
13	digestive/alimentary	MP:0005381	10.06	ERBB2 ETV6 FGFR3 GNAS OXT PIK3CA
14	reproductive system	MP:0005389	10.02	AKT1 ARID1A ERBB2 FGFR3 KMT2C NTRK3
15	respiratory system	MP:0005388	9.97	AKT1 ERBB2 FGFR3 GNAS NTRK3 PIK3CB
16	skeleton	MP:0005390	9.96	AKT1 ARID1A ERBB2 ETV6 FGFR3 GNAS
17	hematopoietic system	MP:0005397	9.9	AKT1 ARID1A ERBB2 ETV6 FGFR3 GNAS
18	mortality/aging	MP:0010768	9.83	AKT1 ARID1A ERBB2 ETV6 FGFR3 GNAS
19	integument	MP:0010771	9.36	AKT1 ERBB2 ETV6 FGF12 FGFR3 GNAS

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Drugs & Therapeutics for Breast Juvenile Papillomatosis

Search Clinical Trials, NIH Clinical Center for Breast Juvenile Papillomatosis

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Genetic Tests for Breast Juvenile Papillomatosis

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Anatomical Context for Breast Juvenile Papillomatosis

Organs/tissues related to Breast Juvenile Papillomatosis:

MalaCards : Breast

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Publications for Breast Juvenile Papillomatosis

Articles related to Breast Juvenile Papillomatosis:

(show all 28)

#	Title	Authors	PMID	Year
1	Juvenile Papillomatosis in a Young Child: A Case of Infantile Bloody Nipple Discharge. ⁶²	Tourlamain G...Logghe K	32717364	2020
2	Juvenile papillomatosis of the breast (Swiss cheese disease) has frequent associations with PIK3CA and/or AKT1 mutations. ⁶²	Guillet C...Varga Z	32088208	2020
3	Juvenile Papillomatosis: A Case Report. ⁶²	Vandeweerd V...Neven P	31001616	2019
4	Giant juvenile papillomatosis of the breast in a Nigerian girl. ⁶²	Olarinoye-Akorede SA...Kajogbola GA	30567257	2018
5	Juvenile Papillomatosis of the Breast in a Pre-Pubertal Girl: An Uncommon Diagnosis. ⁶²	Kafadar MT...Tarini EZ	29322120	2018
6	Juvenile Papillomatosis (Swiss-Cheese Disease) of Breast in an Adult Male With Sequential Diagnoses of Ipsilateral Intraductal, Invasive, and Widely Metastatic Carcinoma: A Case Report and Review of the Disease in Males. ⁶²	Viswanathan K...Hoda SA	28420303	2017
7	Magnetic resonance imaging findings of breast juvenile papillomatosis. ⁶²	Durur-Subasi I...Gundogdu C	23475601	2013
8	Juvenile papillomatosis of the breast in young male: a case report. ⁶²	Sanguinetti A...Avenia N	22018260	2011
9	Juvenile papillomatosis of the breast associated with neurofibromatosis 1. ⁶²	Tan TY...Chow CW	16883593	2007
10	[Juvenille papillomatosis]. ⁶²	Fellah L...Leconte I	16484940	2006
11	Juvenile papillomatosis of the breast in a male infant with Noonan syndrome, café au lait spots, and family history of breast carcinoma. ⁶²	Pacilli M...Pierro A	15700254	2005
12	[Juvenile papillomatosis of the breast]. ⁶²	Noccioli P...Cianchetti E	12870277	2003
13	Juvenile papillomatosis of the breast in a 9-year-old girl. ⁶²	Hsieh SC...Chou JM	11315290	2001
14	A case of breast cancer associated with juvenile papillomatosis of the male breast. ⁶²	Munitiz V...Parrilla P	11078621	2000
15	Juvenile papillomatosis of the breast in male infants: two case reports. ⁶²	Rice HE...Azizkhan RG	10663852	2000
16	[Breast malignancy in girls]. ⁶²	Rzepka-Gorska I...Blogowska A	10462972	1999
17	A Case of Multiple Juvenile Papillomatosis of the Breast and Its Immunohistochemical Pathology. ⁶²	Nio Y...Tamura K	11091647	1998
18	Juvenile papillomatosis of the breast (Swiss cheese disease) ⁶²	Hidalgo F...Marhuenda A	9275926	1997
19	Giant juvenile papillomatosis of the breast: report of two cases. ⁶²	Farid MK...Visveswara RN	9185400	1997
20	Case report: MR imaging of juvenile papillomatosis of the breast. ⁶²	Mussurakis S...Turnbull LW	8983594	1996
21	Juvenile papillomatosis of the breast. ⁶²	Talisman R...Pfeffermann R	8103370	1993
22	Juvenile papillomatosis of the breast. A multidisciplinary study. ⁶²	Taffurelli M...Marrano D	2014142	1991
23	The continuing evolution of our understanding of juvenile papillomatosis of the breast. ⁶²	Dehner LP	2158228	1990
24	Juvenile papillomatosis of the breast. A follow-up study of 41 patients having biopsies before 1979. ⁶²	Rosen PP...Kimmel M	2158224	1990
25	Juvenile papillomatosis of the breast: sonographic appearance. ⁶²	Kersschot EA...Van Hoorde P	3055027	1988
26	[Intraductal juvenile papillomatosis of the breast]. ⁶²	Schulz HJ...Winzer KJ	3617975	1987
27	Juvenile papillomatosis of the breast and family history of breast carcinoma. ⁶²	Rosen PP...Beattie EJ	7074576	1982
28	Juvenile papillomatosis (Swiss cheese disease) of the breast. ⁶²	Rosen PP...DePalo A	7361994	1980

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Genes for Breast Juvenile Papillomatosis

Genes related to Breast Juvenile Papillomatosis (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NUP93	Nucleoporin 93	Protein Coding	4.9	DISEASES inferred ¹⁴
2	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	4.72	DISEASES inferred ¹⁴
3	FGF12	Fibroblast Growth Factor 12	Protein Coding	4.62	DISEASES inferred ¹⁴
4	SMG1	SMG1 Nonsense Mediated MRNA Decay Associated PI3K Related Kinase	Protein Coding	4.21	DISEASES inferred ¹⁴
5	STAG2	Stromal Antigen 2	Protein Coding	3.95	DISEASES inferred ¹⁴
6	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	3.74	DISEASES inferred ¹⁴
7	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	3.57	DISEASES inferred ¹⁴
8	KMT2C	Lysine Methyltransferase 2C	Protein Coding	3.56	DISEASES inferred ¹⁴
9	NTRK3	Neurotrophic Receptor Tyrosine Kinase 3	Protein Coding	3.42	DISEASES inferred ¹⁴
10	GNAS	GNAS Complex Locus	Protein Coding	3.34	DISEASES inferred ¹⁴
11	ETV6	ETS Variant Transcription Factor 6	Protein Coding	3.33	DISEASES inferred ¹⁴
12	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	3.16	DISEASES inferred ¹⁴
13	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	3.1	DISEASES inferred ¹⁴
14	ARID1A	AT-Rich Interaction Domain 1A	Protein Coding	3.09	DISEASES inferred ¹⁴
15	OXT	Oxytocin/Neurophysin I Prepropeptide	Protein Coding	2.99	DISEASES inferred ¹⁴
16	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	2.99	DISEASES inferred ¹⁴
17	PTEN	Phosphatase And Tensin Homolog	Protein Coding	2.81	DISEASES inferred ¹⁴
18	TAC1	Tachykinin Precursor 1	Protein Coding	2.8	DISEASES inferred ¹⁴

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Variations for Breast Juvenile Papillomatosis

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Expression for Breast Juvenile Papillomatosis

Search GEO for disease gene expression data for Breast Juvenile Papillomatosis.

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Pathways for Breast Juvenile Papillomatosis

Pathways related to Breast Juvenile Papillomatosis according to GeneCards Suite gene sharing:

(show top 50) (show all 86)

#	Super pathways	Score	Top Affiliating Genes
1	Disease ⁶⁶ Show member pathways Infectious disease ⁶⁶	13.83	AKT1 ERBB2 ETV6 FGFR3 GNAS NUP93
2	Signal Transduction ⁶⁶	13.74	AKT1 ERBB2 FGFR3 GNAS NTRK3 OXT
3	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.56	PIK3CB PIK3CA NTRK3 GNAS FGFR3 FGF12
4	Prolactin Signaling ⁶⁴ Show member pathways Development Prolactin receptor signaling ²² EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ⁷⁴ ErbB Family Pathway ⁶⁴ ErbB signaling pathway ⁷⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Estrogen-stimulated signaling through PRKCZ ⁶⁶ Glioblastoma Multiforme ⁶⁴ Glioblastoma signaling pathways ⁷⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-2 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ TCA cycle nutrient use and invasiveness of ovarian cancer ⁷⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVA-Induced MAPK Signaling ⁶⁴ UVB-Induced MAPK Signaling ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	13.49	PTEN PIK3CB PIK3CA PIK3C2A GNAS FGFR3
5	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.44	PTEN NTRK3 GNAS FGFR3 FGF12 ERBB2
6	RAF/MAP kinase cascade ⁶⁶ Show member pathways Diseases of signal transduction by growth factor receptors and second messengers ⁶⁶ MAPK family signaling cascades ⁶⁶ MAPK1/MAPK3 signaling ⁶⁶	13.4	PTEN PIK3CB PIK3CA FGFR3 ETV6 ERBB2
7	CREB Pathway ⁶⁴ Show member pathways Activation of PKC through GPCR ⁶⁴ Intracellular Calcium Signaling ⁶⁴ IP3 Pathway ⁶⁴	13.33	PTEN NTRK3 GNAS FGFR3 FGF12 ERBB2
8	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.3	PTEN NTRK3 FGFR3 FGF12 ERBB2 AKT1
9	Nanog in Mammalian ESC Pluripotency ⁶⁴ Show member pathways 14-3-3 Induced Intracellular Signaling ⁶⁴ eNOS Signaling ⁶⁴ GSK3 Signaling ⁶⁴	13.28	AKT1 ERBB2 FGF12 FGFR3 GNAS NTRK3
10	PIP3 activates AKT signaling ⁶⁶ Show member pathways Intracellular signaling by second messengers ⁶⁶ PTEN Regulation ⁶⁶ Regulation of PTEN gene transcription ⁶⁶ Regulation of PTEN localization ⁶⁶	13.1	PTEN PIK3CB PIK3CA FGFR3 ERBB2 AKT1
11	Phospholipase-C Pathway ⁶⁴ Show member pathways PTEN Pathway ⁶⁴	13.1	AKT1 FGF12 FGFR3 GNAS NTRK3 PTEN
12	PI3K-Akt signaling pathway ⁷⁴ Show member pathways Focal adhesion: PI3K-Akt-mTOR-signaling pathway ⁷⁴	12.96	PTEN PIK3CB PIK3CA PIK3C2A FGFR3 FGF12
13	Beta-Adrenergic Signaling ⁶⁴ Show member pathways CDK5 Pathway ⁶⁴ Erythropoietin Pathway ⁶⁴ Insulin Pathway ⁷⁰ Insulin Receptor Pathway ⁶⁴	12.91	PIK3CB PIK3CA PIK3C2A GNAS AKT1
14	Signaling by Receptor Tyrosine Kinases ⁶⁶	12.86	AKT1 ERBB2 FGFR3 NTRK3 PIK3CA PIK3CB
15	Endometrial cancer ⁷⁴ Show member pathways Chromosomal and microsatellite instability in colorectal cancer ⁷⁴ Melanoma ⁷⁴ Non-small cell lung cancer ⁷⁴ Pancreatic adenocarcinoma pathway ⁷⁴ Signal transduction PTEN pathway ²²	12.73	PTEN PIK3CB PIK3CA FGFR3 ERBB2 AKT1
16	NFAT and Cardiac Hypertrophy ⁶⁴ Show member pathways IGF1R Signaling ⁶⁴ Signaling Involved in Cardiac Hypertrophy ⁶⁴	12.71	PTEN PIK3CB PIK3CA NTRK3 GNAS FGFR3
17	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ⁶⁶ Show member pathways Constitutive Signaling by Aberrant PI3K in Cancer ⁶⁶ Negative regulation of the PI3K/AKT network ⁶⁶ PI3K/AKT Signaling in Cancer ⁶⁶	12.69	AKT1 ERBB2 FGFR3 PIK3CA PIK3CB PTEN
18	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.66	PIK3CA NTRK3 FGFR3 FGF12 AKT1
19	Malignant pleural mesothelioma ⁷⁴	12.61	AKT1 FGF12 FGFR3 KMT2C PIK3CA PIK3CB
20	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.59	PIK3CB PIK3CA ERBB2 AKT1
21	Angiopoietin-like protein 8 regulatory pathway ⁷⁴ Show member pathways Insulin signaling ⁷⁴ Liver X receptor pathway ⁷⁴	12.55	PTEN PIK3CB PIK3CA PIK3C2A AKT1
22	Development EGFR signaling pathway ²² Show member pathways Development ERBB-family signaling ²² EGF Pathway ⁶⁴ EGFR Signaling Pathway ⁶⁷ ErbB receptor signaling network ⁶¹	12.53	PIK3CB PIK3CA ERBB2 AKT1
23	Breast cancer pathway ⁷⁴ Show member pathways Embryonic stem cell pluripotency pathways ⁷⁴	12.47	AKT1 ERBB2 FGF12 FGFR3 PIK3CA PTEN
24	Hepatocyte growth factor receptor signaling ⁷⁴ Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development HGF signaling pathway ²² Development Neurotrophin family signaling ²² Drug-mediated inhibition of MET activation ⁶⁶ MET activates PTPN11 ⁶⁶ MET activates STAT3 ⁶⁶ PLC-gamma1 signalling ⁶⁶ Trk receptor signaling mediated by PI3K and PLC-gamma ⁶¹ TRKA activation by NGF ⁶⁶	12.46	AKT1 ERBB2 NTRK3 PIK3CA PIK3CB PTEN
25	PI Metabolism ⁶⁶ Show member pathways Glycerophospholipid catabolism ⁶⁶ Phosphoinositides metabolism ⁷⁴ PI and PC transport between ER and Golgi membranes ⁶⁶ Synthesis of PIPs at the early endosome membrane ⁶⁶ Synthesis of PIPs at the ER membrane ⁶⁶ Synthesis of PIPs at the Golgi membrane ⁶⁶ Synthesis of PIPs at the late endosome membrane ⁶⁶ Synthesis of PIPs at the plasma membrane ⁶⁶	12.44	PIK3C2A PIK3CA PIK3CB PTEN
26	Development FGFR signaling pathway ²² Show member pathways Development FGF-family signaling ²² Development Flt3 signaling ²² FGF Pathway ⁶⁴	12.43	PIK3CB PIK3CA FGFR3 FGF12 AKT1
27	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ⁶¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ⁶¹	12.42	PIK3CA NTRK3 FGFR3 FGF12 ERBB2
28	Immune response Fc epsilon RI pathway ²² Show member pathways Fc-epsilon receptor I signaling in mast cells ⁶¹ Immune response BCR pathway ²²	12.37	PTEN PIK3CB PIK3CA AKT1
29	Development Ligand-independent activation of ESR1 and ESR2 ²² Show member pathways Transcription CREB pathway ²² Transcription PPAR Pathway ²²	12.36	PIK3CB PIK3CA GNAS ERBB2 AKT1
30	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.35	PIK3CB PIK3CA GNAS AKT1
31	B Cell Receptor Signaling Pathway ⁶⁷ Show member pathways T Cell Receptor Signaling Pathway ⁶⁷	12.35	AKT1 PIK3CA PIK3CB PTEN
32	Focal adhesion ⁷⁴	12.32	PTEN PIK3CB PIK3CA ERBB2 AKT1
33	PDGFR-beta signaling pathway ⁶¹ Show member pathways ErbB1 downstream signaling ⁶¹	12.3	PTEN PIK3CB PIK3CA AKT1
34	Development IGF-1 receptor signaling ²² Show member pathways Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	12.29	PTEN PIK3CB PIK3CA AKT1
35	Ras signaling ⁷⁴	12.27	PIK3CB PIK3CA FGFR3 AKT1
36	Development Endothelin-1/EDNRA transactivation of EGFR ²² Show member pathways Cytoskeleton remodeling FAK signaling ²² Development Endothelin-1/EDNRA signaling ²²	12.27	PIK3CB PIK3CA GNAS AKT1
37	VEGF Signaling Pathway ⁶⁰ ⁶⁷ Show member pathways Nanoparticle-mediated activation of receptor signaling ⁷⁴ TGF-beta Signaling ⁶⁷	12.23	PTEN PIK3CB PIK3C2A FGFR3 AKT1
38	NF-kappaB Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ Apoptosis Pathway ⁷⁰	12.21	PIK3CB PIK3CA PIK3C2A NTRK3 FGFR3 ERBB2
39	Apoptosis and survival BAD phosphorylation ²² Show member pathways BAD Phosphorylation ⁶⁴	12.2	AKT1 GNAS PIK3CA PIK3CB
40	Transcription Androgen Receptor nuclear signaling ²² Show member pathways Translation Non-genomic (rapid) action of Androgen Receptor ²²	12.16	PTEN PIK3CA ERBB2 AKT1
41	Regulation of actin cytoskeleton ⁷⁴	12.15	PIK3CB PIK3CA PIK3C2A FGFR3 FGF12
42	mTOR Signaling ⁶⁵	12.11	PTEN PIK3CB FGFR3 ERBB2 AKT1
43	Development A2B receptor- action via G-protein alpha s ²² Show member pathways Development A2A receptor signaling ²²	12.07	PIK3CB PIK3CA GNAS AKT1
44	MAPK Signaling: Mitogens ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	12.05	AKT1 ERBB2 FGFR3 NTRK3 PIK3CA PIK3CB
45	MAPK Pathway ⁷⁰ Show member pathways Toll-like Receptor Pathway ⁷⁰	12.02	PIK3CB PIK3CA PIK3C2A ERBB2 AKT1
46	Development EPO-induced Jak-STAT pathway ²² Show member pathways EPO receptor signaling ⁷⁴ Signaling events mediated by Stem cell factor receptor (c-Kit) ⁶¹	12.01	PTEN PIK3CA AKT1
47	Small cell lung cancer ⁷⁴	11.93	PTEN PIK3CB PIK3CA AKT1
48	DNA damage response (only ATM dependent) ⁷⁴	11.92	PTEN PIK3CB PIK3CA PIK3C2A ERBB2
49	mTOR Pathway ⁷⁰ Show member pathways TGF-beta Pathway ⁷⁰	11.84	AKT1 PIK3C2A PIK3CA PIK3CB
50	VEGF Pathway (Tocris) ⁷⁰ Show member pathways Sorafenib Pharmacodynamics ⁶⁰	11.84	AKT1 PIK3C2A PIK3CA PIK3CB

Sources

GO Terms for Breast Juvenile Papillomatosis

Cellular components related to Breast Juvenile Papillomatosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	phosphatidylinositol 3-kinase complex, class IA	GO:0005943	9.26	PIK3CB PIK3CA
2	phosphatidylinositol 3-kinase complex	GO:0005942	9.1	PIK3CB PIK3CA PIK3C2A

Biological processes related to Breast Juvenile Papillomatosis according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	protein autophosphorylation	GO:0046777	10.16	SMG1 FGFR3 ERBB2 AKT1
2	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	10.11	ERBB2 FGFR3 NTRK3 PIK3CB
3	nervous system development	GO:0007399	10.08	PTEN NTRK3 FGF12 ERBB2 ARID1A AKT1
4	heart development	GO:0007507	10.07	PTEN OXT NTRK3 FGF12 ERBB2
5	protein kinase B signaling	GO:0043491	10.02	PTEN PIK3CA AKT1
6	epidermal growth factor receptor signaling pathway	GO:0007173	10.01	PIK3CA PIK3C2A AKT1
7	phosphatidylinositol-mediated signaling	GO:0048015	10	PIK3CB PIK3CA PIK3C2A
8	cellular response to nerve growth factor stimulus	GO:1990090	9.91	TAC1 NTRK3 AKT1
9	male mating behavior	GO:0060179	9.8	PTEN OXT
10	phosphatidylinositol-3-phosphate biosynthetic process	GO:0036092	9.8	PIK3CB PIK3CA PIK3C2A
11	phosphatidylinositol phosphate biosynthetic process	GO:0046854	9.76	PIK3C2A PIK3CA PIK3CB SMG1
12	negative regulation of macroautophagy	GO:0016242	9.73	SMG1 PIK3CA AKT1
13	phosphorylation	GO:0016310	9.73	SMG1 PIK3CB PIK3CA PIK3C2A NTRK3 FGFR3
14	postsynaptic density assembly	GO:0097107	9.63	PTEN NTRK3
15	cellular response to decreased oxygen levels	GO:0036294	9.58	AKT1 PTEN
16	phosphatidylinositol 3-kinase signaling	GO:0014065	9.4	PTEN PIK3CB PIK3CA PIK3C2A ERBB2 AKT1

Molecular functions related to Breast Juvenile Papillomatosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleotide binding	GO:0000166	10.11	SMG1 PIK3CB PIK3CA PIK3C2A NTRK3 GNAS
2	transferase activity	GO:0016740	10.09	SMG1 PIK3CB PIK3CA PIK3C2A NTRK3 KMT2C
3	transmembrane receptor protein tyrosine kinase activity	GO:0004714	9.95	NTRK3 FGFR3 ERBB2
4	phosphatidylinositol kinase activity	GO:0052742	9.88	PIK3CB PIK3CA PIK3C2A
5	1-phosphatidylinositol-3-kinase activity	GO:0016303	9.85	PIK3C2A PIK3CA PIK3CB
6	phosphatidylinositol-3,4-bisphosphate 5-kinase activity	GO:0052812	9.8	PIK3C2A PIK3CA PIK3CB
7	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	9.73	PIK3CB PIK3CA PIK3C2A
8	1-phosphatidylinositol-4-phosphate 3-kinase activity	GO:0035005	9.63	PIK3CB PIK3CA PIK3C2A
9	phosphatidylinositol 3-kinase activity	GO:0035004	9.43	PIK3CB PIK3CA PIK3C2A
10	kinase activity	GO:0016301	9.36	SMG1 PIK3CB PIK3CA PIK3C2A NTRK3 FGFR3

Sources

Sources for Breast Juvenile Papillomatosis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: BRS025 MIFTS: 32	Breast Juvenile Papillomatosis Categories: Cancer diseases	Data Licensing For inquiries, contact: [email protected]
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