MCID: BRS043
MIFTS: 27

Breast Leiomyosarcoma

Categories: Cancer diseases

Aliases & Classifications for Breast Leiomyosarcoma

MalaCards integrated aliases for Breast Leiomyosarcoma:

Name: Breast Leiomyosarcoma 12 15 72
Leiomyosarcoma of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5285
NCIt 50 C5186
UMLS 72 C1332631

Summaries for Breast Leiomyosarcoma

Disease Ontology : 12 A breast sarcoma that arises from smooth muscle cells.

MalaCards based summary : Breast Leiomyosarcoma, also known as leiomyosarcoma of the breast, is related to mesenchymal cell neoplasm and giant cell tumor. An important gene associated with Breast Leiomyosarcoma is CHEK2 (Checkpoint Kinase 2), and among its related pathways/superpathways are NF-kappaB Signaling and Osteoclast differentiation. Affiliated tissues include breast, smooth muscle and lung, and related phenotype is neoplasm.

Related Diseases for Breast Leiomyosarcoma

Diseases related to Breast Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 mesenchymal cell neoplasm 29.4 CD34 CALD1
2 giant cell tumor 29.3 TNFSF11 TNFRSF11A
3 leiomyosarcoma 10.4
4 polyarticular onset juvenile idiopathic arthritis 10.2 TNFSF11 TNFRSF11A
5 hemophilic arthropathy 10.2 TNFSF11 TNFRSF11A
6 osteopetrosis, autosomal recessive 7 10.2 TNFSF11 TNFRSF11A
7 osteopetrosis 10.2 TNFSF11 TNFRSF11A
8 paget disease of bone 5, juvenile-onset 10.2 TNFSF11 TNFRSF11A
9 familial expansile osteolysis 10.2 TNFSF11 TNFRSF11A
10 periapical periodontitis 10.1 TNFSF11 TNFRSF11A
11 aneurysmal bone cysts 10.1 TNFSF11 TNFRSF11A
12 osteopetrosis, autosomal recessive 2 10.1 TNFSF11 TNFRSF11A
13 multicentric carpotarsal osteolysis syndrome 10.1 TNFSF11 TNFRSF11A
14 tooth resorption 10.1 TNFSF11 TNFRSF11A
15 ischemic bone disease 10.0 TNFSF11 TNFRSF11A
16 root resorption 10.0 TNFSF11 TNFRSF11A
17 leiomyoma 10.0
18 breast sarcoma 10.0
19 bone resorption disease 9.9 TNFSF11 TNFRSF11A
20 connective tissue cancer 9.9 TNFSF11 CD34
21 bone remodeling disease 9.9 TNFSF11 TNFRSF11A
22 intravascular fasciitis 9.9 CD34 CALD1
23 breast myofibroblastoma 9.9 CD34 CALD1
24 glomangiomyoma 9.8 CD34 CALD1
25 angiomyoma 9.8 CD34 CALD1
26 systemic lupus erythematosus 9.8
27 retinoblastoma 9.8
28 leukemia 9.8
29 breast fibroadenoma 9.8
30 benign breast phyllodes tumor 9.8
31 embryonal rhabdomyosarcoma 9.8
32 rhabdomyosarcoma 9.8
33 orbit embryonal rhabdomyosarcoma 9.8
34 orbit rhabdomyosarcoma 9.8
35 bone giant cell tumor 9.8
36 familial retinoblastoma 9.8
37 epithelioid leiomyosarcoma 9.8
38 posttransplant acute limbic encephalitis 9.8
39 deep leiomyoma 9.8 CD34 CALD1
40 lung cancer susceptibility 3 9.8
41 lymphoma 9.8
42 kidney leiomyosarcoma 9.8
43 rare tumor 9.8
44 paget's disease of bone 9.8 TNFSF11 TNFRSF11A
45 conventional fibrosarcoma 9.8 CD34 CALD1
46 diffuse peritoneal leiomyomatosis 9.8 CD34 CALD1
47 peritoneal benign neoplasm 9.8 CD34 CALD1
48 pseudosarcomatous fibromatosis 9.8 CD34 CALD1
49 sarcomatoid squamous cell skin carcinoma 9.7 CD34 CALD1
50 benign perivascular tumor 9.7 CD34 CALD1

Graphical network of the top 20 diseases related to Breast Leiomyosarcoma:



Diseases related to Breast Leiomyosarcoma

Symptoms & Phenotypes for Breast Leiomyosarcoma

MGI Mouse Phenotypes related to Breast Leiomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 CD34 CHEK2 TNFRSF11A TNFSF11

Drugs & Therapeutics for Breast Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Breast Leiomyosarcoma

Genetic Tests for Breast Leiomyosarcoma

Anatomical Context for Breast Leiomyosarcoma

MalaCards organs/tissues related to Breast Leiomyosarcoma:

41
Breast, Smooth Muscle, Lung

Publications for Breast Leiomyosarcoma

Articles related to Breast Leiomyosarcoma:

(show top 50) (show all 55)
# Title Authors PMID Year
1
Pancreatic Metastasis from Primary Leiomyosarcoma of the Breast. 38
31192295 2019
2
Breast leiomyosarcoma with myxoid aspects. 38
30033605 2018
3
Positive response of a primary leiomyosarcoma of the breast following salvage hyperthermia and pazopanib. 38
27079325 2018
4
Primary breast leiomyosarcoma with metastases to the lung in a young adult: Case report and literature review. 38
29705677 2018
5
Primary breast leiomyosarcoma and synchronous homolateral lung cancer: a case report. 38
29312765 2017
6
Primary breast leiomyosarcoma located in the premammary zone: a case report. 38
26278012 2015
7
Primary leiomyosarcoma of the breast with prominent osteoclastic giant cells: A case expressing receptor activator of NF-κB ligand (RANKL). 38
26150133 2015
8
Case Report: Primary Leiomyosarcoma of the breast with unusual metastasis to the femur. 38
25469230 2014
9
Twenty-year-old female with leiomyosarcoma of the breast. 38
24876324 2014
10
[Clinicopathologic characteristics of primary breast leiomyosarcoma: report of a case]. 38
24447557 2013
11
Leiomyosarcoma of the female breast: report of a case. 38
24426525 2013
12
18F-FDG imaging of the primary breast leiomyosarcoma and follow-up lung metastasis. 38
23354027 2013
13
Primary breast leiomyosarcoma. 38
24455361 2013
14
Primary leiomyosarcoma of the breast: a case report. 38
22493639 2012
15
Primary leiomyosarcoma of the breast. 38
22060672 2012
16
Primary leiomyosarcoma of breast in an adolescent girl: a case report and review of the literature. 38
22953134 2012
17
Leiomyosarcoma of the breast: a case report and review of the literature about therapeutic management. 38
21530255 2011
18
Leiomyosarcoma of the breast. 38
24950039 2011
19
Primary leiomyosarcoma of the breast treated by partial resection of the breast including nipple and areola: report of a case. 38
21046506 2010
20
Primary Leiomyosarcoma of the Male Breast. 38
29147209 2010
21
Primary leiomyosarcoma of the breast: A case report and review of literature. 38
23133273 2010
22
Primary leiomyosarcoma of the male breast: a case report. 38
21048931 2010
23
Primary leiomyosarcoma of the breast. 38
19601949 2009
24
Leiomyosarcoma of the breast in a patient with a 10-year-history of cyclophosphamide exposure: a case report. 38
18992149 2008
25
Primary leiomyosarcoma of the nipple-areola complex: report of a case and review of literature. 38
18257132 2008
26
Needle aspiration cytology and immunohistologic findings in a case of leiomyosarcoma of the breast. 38
17351941 2007
27
Image of the month--leiomyosarcoma of the breast. 38
17178971 2006
28
Leiomyosarcoma of the breast: report of a case with fine needle aspiration cytologic, histologic and immunohistochemical features. 38
16450908 2005
29
A 53-year-old woman with a leiomyosarcoma of the breast. 38
15590026 2004
30
Primitive leiomyosarcoma of the breast: case report and review of the literature. 38
14759721 2004
31
Leiomyosarcoma of the breast: a pathologic and comparative genomic hybridization study of two cases. 38
15104283 2004
32
Primary leiomyosarcoma of the breast: a case report with review of the literature. 38
14616945 2003
33
Leiomyosarcoma of the breast: a difficult diagnosis on fine-needle aspiration biopsy. 38
12951688 2003
34
Leiomyosarcoma of the breast. A clinicopathologic and immunohistochemical study. 38
12551801 2003
35
[Leiomyosarcoma of the breast]. 38
14639868 2003
36
Primary leiomyosarcoma of the breast: report of a case. 38
12181723 2002
37
Primary leiomyosarcoma of the breast: diagnosis, management and outcome. A report of a new case and review of literature. 38
14965634 2001
38
Leiomyosarcoma of the female breast. 38
11458280 2001
39
Fine needle aspiration cytodiagnosis of leiomyosarcoma of the breast. A case report. 38
11127743 2000
40
Leiomyosarcoma of the female breast: report of two new cases and a review of the literature. 38
9208974 1997
41
Primary leiomyosarcoma of the breast. 38
9413066 1997
42
Breast metastases from primary leiomyosarcoma. 38
9033385 1997
43
Leiomyosarcoma of the breast. A case report. 38
7631250 1995
44
Epithelioid leiomyosarcoma of the breast: report of a case. 38
8104588 1993
45
[Leiomyosarcoma of the breast 16 years following successful treatment of a rhabdomyosarcoma of the orbit in childhood]. 38
1411391 1992
46
Primary leiomyosarcoma of the breast. 38
1555069 1992
47
Leiomyosarcoma of the breast; cytological and histological features, with a review of the literature. 38
1421007 1992
48
Primary recurrent leiomyosarcoma of the breast. Case report with ultrastructural and immunohistochemical study and review of the literature. 38
2679042 1989
49
Leiomyosarcoma of the breast--a case report and an electron microscopic study. 38
6543377 1984
50
Primary leiomyosarcoma of the breast. 38
6493566 1984

Variations for Breast Leiomyosarcoma

Expression for Breast Leiomyosarcoma

Search GEO for disease gene expression data for Breast Leiomyosarcoma.

Pathways for Breast Leiomyosarcoma

GO Terms for Breast Leiomyosarcoma

Biological processes related to Breast Leiomyosarcoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.49 TNFSF11 TNFRSF11A
2 ossification GO:0001503 9.48 TNFSF11 TNFRSF11A
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.46 TNFSF11 TNFRSF11A
4 monocyte chemotaxis GO:0002548 9.43 TNFSF11 TNFRSF11A
5 osteoclast differentiation GO:0030316 9.4 TNFSF11 TNFRSF11A
6 positive regulation of bone resorption GO:0045780 9.37 TNFSF11 TNFRSF11A
7 mammary gland alveolus development GO:0060749 9.32 TNFSF11 TNFRSF11A
8 paracrine signaling GO:0038001 9.26 TNFSF11 CD34
9 TNFSF11-mediated signaling pathway GO:0071847 9.16 TNFSF11 TNFRSF11A
10 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.96 TNFSF11 TNFRSF11A
11 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 8.62 TNFSF11 TNFRSF11A

Sources for Breast Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....