MCID: BRS043
MIFTS: 30

Breast Leiomyosarcoma

Categories: Cancer diseases

Aliases & Classifications for Breast Leiomyosarcoma

MalaCards integrated aliases for Breast Leiomyosarcoma:

Name: Breast Leiomyosarcoma 12 15 71
Leiomyosarcoma of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5285
NCIt 49 C5186
UMLS 71 C1332631

Summaries for Breast Leiomyosarcoma

Disease Ontology : 12 A breast sarcoma that arises from smooth muscle cells.

MalaCards based summary : Breast Leiomyosarcoma, also known as leiomyosarcoma of the breast, is related to leiomyosarcoma and epithelioid leiomyosarcoma. An important gene associated with Breast Leiomyosarcoma is CHEK2 (Checkpoint Kinase 2), and among its related pathways/superpathways are NF-kappaB Signaling and Rheumatoid arthritis. Affiliated tissues include breast, smooth muscle and bone, and related phenotypes are homeostasis/metabolism and neoplasm

Related Diseases for Breast Leiomyosarcoma

Diseases related to Breast Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 259)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 29.9 VEGFA MB KIT ENO2
2 epithelioid leiomyosarcoma 29.9 MB ENO2 CALD1
3 mesenchymal cell neoplasm 29.8 KIT CD34 CALD1
4 rhabdomyosarcoma 29.1 VEGFA MB KIT ENO2
5 subareolar duct papillomatosis 10.5 KRT7 CALD1
6 nipple neoplasm 10.5 KRT7 CALD1
7 cervical adenoma malignum 10.5 KRT7 CALD1
8 polyarticular onset juvenile idiopathic arthritis 10.5 TNFSF11 TNFRSF11A
9 vaginal benign neoplasm 10.5 KRT7 CALD1
10 hemophilic arthropathy 10.5 TNFSF11 TNFRSF11A
11 urethral benign neoplasm 10.5 KRT7 CALD1
12 paget disease of bone 5, juvenile-onset 10.4 TNFSF11 TNFRSF11A
13 urethra leiomyoma 10.4 KIT CALD1
14 lung clear cell carcinoma 10.4 MB KRT7
15 familial expansile osteolysis 10.4 TNFSF11 TNFRSF11A
16 uterine corpus sarcoma 10.4 KIT CALD1
17 gallbladder signet ring cell adenocarcinoma 10.4 TTR KRT7
18 vagina leiomyosarcoma 10.4 KIT CALD1
19 aneurysmal bone cysts 10.4 TNFSF11 TNFRSF11A
20 benign peritoneal mesothelioma 10.4 KRT7 CALD1
21 cervical mucinous adenocarcinoma 10.4 KRT7 CALD1
22 gastric leiomyoma 10.4 KIT CALD1
23 adenomyoma 10.4 KRT7 CALD1
24 anus basaloid carcinoma 10.4 KRT7 KIT
25 cervical adenoid cystic carcinoma 10.4 KRT7 KIT
26 ceruminous adenocarcinoma 10.4 KRT7 KIT
27 glomangioma 10.4 CD34 CALD1
28 adenoid basal cell carcinoma 10.4 KRT7 KIT
29 intratubular embryonal carcinoma 10.4 KRT7 KIT
30 atrophic glossitis 10.3 TTR MB
31 alexia 10.3 KCNK5 KCNK3
32 intravascular angioleiomyoma 10.3 CD34 CALD1
33 breast myofibroblastoma 10.3 CD34 CALD1
34 pulmonary vein leiomyosarcoma 10.3 CD34 CALD1
35 vagina leiomyoma 10.3 CD34 CALD1
36 glomangiomyoma 10.3 CD34 CALD1
37 glomangiosarcoma 10.3 CD34 CALD1
38 warthin tumor 10.3 KRT7 KIT
39 prosopagnosia 10.3 KCNK5 KCNK3
40 central nervous system fibrosarcoma 10.3 KRT7 CD34
41 benign perivascular tumor 10.3 CD34 CALD1
42 thymus clear cell carcinoma 10.3 KRT7 KIT
43 ovarian mixed germ cell neoplasm 10.3 TTR KIT
44 intravascular fasciitis 10.3 CD34 CALD1
45 sarcomatoid squamous cell skin carcinoma 10.3 CD34 CALD1
46 vaginal cancer 10.3 KRT7 CALD1
47 spindle cell synovial sarcoma 10.3 CD34 CALD1
48 bone leiomyosarcoma 10.3 TNFSF11 KRT7 CALD1
49 testicular fibroma 10.3 CD34 CALD1
50 cervical polyp 10.3 CD34 CALD1

Graphical network of the top 20 diseases related to Breast Leiomyosarcoma:



Diseases related to Breast Leiomyosarcoma

Symptoms & Phenotypes for Breast Leiomyosarcoma

MGI Mouse Phenotypes related to Breast Leiomyosarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.97 ARG1 CD34 CHEK2 KCNK3 KCNK5 KIT
2 neoplasm MP:0002006 9.43 CD34 CHEK2 KIT TNFRSF11A TNFSF11 VEGFA
3 respiratory system MP:0005388 9.28 ENO2 KCNK3 KCNK5 KIT LDB3 MB

Drugs & Therapeutics for Breast Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Breast Leiomyosarcoma

Genetic Tests for Breast Leiomyosarcoma

Anatomical Context for Breast Leiomyosarcoma

MalaCards organs/tissues related to Breast Leiomyosarcoma:

40
Breast, Smooth Muscle, Bone, Lung, Small Intestine, Prostate, Colon

Publications for Breast Leiomyosarcoma

Articles related to Breast Leiomyosarcoma:

(show top 50) (show all 55)
# Title Authors PMID Year
1
Pancreatic Metastasis from Primary Leiomyosarcoma of the Breast. 61
31192295 2019
2
Breast leiomyosarcoma with myxoid aspects. 61
30033605 2018
3
Positive response of a primary leiomyosarcoma of the breast following salvage hyperthermia and pazopanib. 61
27079325 2018
4
Primary breast leiomyosarcoma with metastases to the lung in a young adult: Case report and literature review. 61
29705677 2018
5
Primary breast leiomyosarcoma and synchronous homolateral lung cancer: a case report. 61
29312765 2017
6
Primary breast leiomyosarcoma located in the premammary zone: a case report. 61
26278012 2015
7
Primary leiomyosarcoma of the breast with prominent osteoclastic giant cells: A case expressing receptor activator of NF-κB ligand (RANKL). 61
26150133 2015
8
Twenty-year-old female with leiomyosarcoma of the breast. 61
24876324 2014
9
Case Report: Primary Leiomyosarcoma of the breast with unusual metastasis to the femur. 61
25469230 2014
10
[Clinicopathologic characteristics of primary breast leiomyosarcoma: report of a case]. 61
24447557 2013
11
Leiomyosarcoma of the female breast: report of a case. 61
24426525 2013
12
18F-FDG imaging of the primary breast leiomyosarcoma and follow-up lung metastasis. 61
23354027 2013
13
Primary breast leiomyosarcoma. 61
24455361 2013
14
Primary leiomyosarcoma of the breast: a case report. 61
22493639 2012
15
Primary leiomyosarcoma of the breast. 61
22060672 2012
16
Primary leiomyosarcoma of breast in an adolescent girl: a case report and review of the literature. 61
22953134 2012
17
Leiomyosarcoma of the breast: a case report and review of the literature about therapeutic management. 61
21530255 2011
18
Leiomyosarcoma of the breast. 61
24950039 2011
19
Primary leiomyosarcoma of the breast treated by partial resection of the breast including nipple and areola: report of a case. 61
21046506 2010
20
Primary Leiomyosarcoma of the Male Breast. 61
29147209 2010
21
Primary leiomyosarcoma of the breast: A case report and review of literature. 61
23133273 2010
22
Primary leiomyosarcoma of the male breast: a case report. 61
21048931 2010
23
Primary leiomyosarcoma of the breast. 61
19601949 2009
24
Leiomyosarcoma of the breast in a patient with a 10-year-history of cyclophosphamide exposure: a case report. 61
18992149 2008
25
Primary leiomyosarcoma of the nipple-areola complex: report of a case and review of literature. 61
18257132 2008
26
Needle aspiration cytology and immunohistologic findings in a case of leiomyosarcoma of the breast. 61
17351941 2007
27
Image of the month--leiomyosarcoma of the breast. 61
17178971 2006
28
Leiomyosarcoma of the breast: report of a case with fine needle aspiration cytologic, histologic and immunohistochemical features. 61
16450908 2005
29
A 53-year-old woman with a leiomyosarcoma of the breast. 61
15590026 2004
30
Primitive leiomyosarcoma of the breast: case report and review of the literature. 61
14759721 2004
31
Leiomyosarcoma of the breast: a pathologic and comparative genomic hybridization study of two cases. 61
15104283 2004
32
Primary leiomyosarcoma of the breast: a case report with review of the literature. 61
14616945 2003
33
Leiomyosarcoma of the breast: a difficult diagnosis on fine-needle aspiration biopsy. 61
12951688 2003
34
Leiomyosarcoma of the breast. A clinicopathologic and immunohistochemical study. 61
12551801 2003
35
[Leiomyosarcoma of the breast]. 61
14639868 2003
36
Primary leiomyosarcoma of the breast: report of a case. 61
12181723 2002
37
Primary leiomyosarcoma of the breast: diagnosis, management and outcome. A report of a new case and review of literature. 61
14965634 2001
38
Leiomyosarcoma of the female breast. 61
11458280 2001
39
Fine needle aspiration cytodiagnosis of leiomyosarcoma of the breast. A case report. 61
11127743 2000
40
Leiomyosarcoma of the female breast: report of two new cases and a review of the literature. 61
9208974 1997
41
Breast metastases from primary leiomyosarcoma. 61
9033385 1997
42
Primary leiomyosarcoma of the breast. 61
9413066 1997
43
Leiomyosarcoma of the breast. A case report. 61
7631250 1995
44
Epithelioid leiomyosarcoma of the breast: report of a case. 61
8104588 1993
45
[Leiomyosarcoma of the breast 16 years following successful treatment of a rhabdomyosarcoma of the orbit in childhood]. 61
1411391 1992
46
Primary leiomyosarcoma of the breast. 61
1555069 1992
47
Leiomyosarcoma of the breast; cytological and histological features, with a review of the literature. 61
1421007 1992
48
Primary recurrent leiomyosarcoma of the breast. Case report with ultrastructural and immunohistochemical study and review of the literature. 61
2679042 1989
49
Leiomyosarcoma of the breast--a case report and an electron microscopic study. 61
6543377 1984
50
Primary leiomyosarcoma of the breast. 61
6493566 1984

Variations for Breast Leiomyosarcoma

Expression for Breast Leiomyosarcoma

Search GEO for disease gene expression data for Breast Leiomyosarcoma.

Pathways for Breast Leiomyosarcoma

Pathways related to Breast Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.97 TNFSF11 TNFRSF11A KIT CD34
2 11.1 VEGFA TNFSF11 TNFRSF11A
3 10.48 VEGFA TNFSF11 KIT
4 10.46 TNFSF11 TNFRSF11A

GO Terms for Breast Leiomyosarcoma

Biological processes related to Breast Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.58 TNFSF11 TNFRSF11A KIT
2 positive regulation of MAP kinase activity GO:0043406 9.5 VEGFA TNFSF11 KIT
3 positive regulation of bone resorption GO:0045780 9.46 TNFSF11 TNFRSF11A
4 stabilization of membrane potential GO:0030322 9.43 KCNK5 KCNK3
5 paracrine signaling GO:0038001 9.37 TNFSF11 CD34
6 TNFSF11-mediated signaling pathway GO:0071847 9.26 TNFSF11 TNFRSF11A
7 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.16 TNFSF11 TNFRSF11A
8 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.96 TNFSF11 TNFRSF11A
9 mammary gland alveolus development GO:0060749 8.8 VEGFA TNFSF11 TNFRSF11A

Molecular functions related to Breast Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion leak channel activity GO:0022841 8.62 KCNK5 KCNK3

Sources for Breast Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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