MCID: BRS043
MIFTS: 29

Breast Leiomyosarcoma

Categories: Cancer diseases

Aliases & Classifications for Breast Leiomyosarcoma

MalaCards integrated aliases for Breast Leiomyosarcoma:

Name: Breast Leiomyosarcoma 12 15 73
Leiomyosarcoma of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5285
NCIt 50 C5186
UMLS 73 C1332631

Summaries for Breast Leiomyosarcoma

Disease Ontology : 12 A breast sarcoma that arises from smooth muscle cells.

MalaCards based summary : Breast Leiomyosarcoma, also known as leiomyosarcoma of the breast, is related to leiomyosarcoma and polyarticular onset juvenile idiopathic arthritis. An important gene associated with Breast Leiomyosarcoma is CHEK2 (Checkpoint Kinase 2), and among its related pathways/superpathways are NF-kappaB Signaling and NF-kappa B signaling pathway. Affiliated tissues include smooth muscle, lung and skin, and related phenotype is neoplasm.

Related Diseases for Breast Leiomyosarcoma

Diseases related to Breast Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 10.3
2 polyarticular onset juvenile idiopathic arthritis 10.1 TNFRSF11A TNFSF11
3 hemophilic arthropathy 10.1 TNFRSF11A TNFSF11
4 osteopetrosis, autosomal recessive 7 10.1 TNFRSF11A TNFSF11
5 osteopetrosis 10.1 TNFRSF11A TNFSF11
6 paget disease of bone 5, juvenile-onset 10.1 TNFRSF11A TNFSF11
7 familial expansile osteolysis 10.1 TNFRSF11A TNFSF11
8 multicentric carpotarsal osteolysis syndrome 10.1 TNFRSF11A TNFSF11
9 osteopetrosis, autosomal recessive 2 10.1 TNFRSF11A TNFSF11
10 aneurysmal bone cysts 10.1 TNFRSF11A TNFSF11
11 periapical periodontitis 10.1 TNFRSF11A TNFSF11
12 tooth resorption 10.1 TNFRSF11A TNFSF11
13 dissociative amnesia 10.1 SMUG1 TNFSF11
14 mandibular cancer 10.1 SMUG1 TNFSF11
15 ischemic bone disease 10.1 TNFRSF11A TNFSF11
16 spleen angiosarcoma 10.1 CD34 SMUG1
17 root resorption 10.1 TNFRSF11A TNFSF11
18 tibial adamantinoma 10.1 CD34 SMUG1
19 sternum cancer 10.1 CD34 SMUG1
20 bone epithelioid hemangioma 10.1 CD34 SMUG1
21 malignant epithelioid hemangioendothelioma 10.1 CD34 SMUG1
22 eccrine adenocarcinoma 10.1 CD34 SMUG1
23 bone resorption disease 10.1 TNFRSF11A TNFSF11
24 breast angiosarcoma 10.1 CD34 SMUG1
25 bone remodeling disease 10.0 TNFRSF11A TNFSF11
26 malignant hemangioma 10.0 CD34 SMUG1
27 giant cell tumor 10.0 TNFRSF11A TNFSF11
28 pediatric lymphoma 10.0 CD34 SMUG1
29 bone cancer 10.0 TNFRSF11A TNFSF11
30 lymphangiosarcoma 10.0 CD34 SMUG1
31 paget's disease of bone 10.0 TNFRSF11A TNFSF11
32 leukocyte disease 10.0 CD34 SMUG1
33 breast myofibroblastoma 10.0 CALD1 CD34
34 intravascular fasciitis 10.0 CALD1 CD34
35 deep leiomyoma 10.0 CALD1 CD34
36 glomangiomyoma 10.0 CALD1 CD34
37 angiomyoma 10.0 CALD1 CD34
38 conventional fibrosarcoma 9.9 CALD1 CD34
39 peritoneal benign neoplasm 9.9 CALD1 CD34
40 diffuse peritoneal leiomyomatosis 9.9 CALD1 CD34
41 periodontal disease 9.9 TNFRSF11A TNFSF11
42 mesenchymal cell neoplasm 9.9 CALD1 CD34
43 pseudosarcomatous fibromatosis 9.9 CALD1 CD34
44 sarcomatoid squamous cell skin carcinoma 9.9 CALD1 CD34
45 cardiovascular organ benign neoplasm 9.9 CALD1 CD34
46 benign perivascular tumor 9.9 CALD1 CD34
47 skin sarcoma 9.9 CALD1 CD34
48 connective tissue cancer 9.9 CD34 SMUG1 TNFSF11
49 gastrointestinal system cancer 9.9 CD34 SMUG1
50 nephrogenic adenofibroma 9.9 CALD1 CD34

Graphical network of the top 20 diseases related to Breast Leiomyosarcoma:



Diseases related to Breast Leiomyosarcoma

Symptoms & Phenotypes for Breast Leiomyosarcoma

MGI Mouse Phenotypes related to Breast Leiomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 CD34 CHEK2 SMUG1 TNFRSF11A TNFSF11

Drugs & Therapeutics for Breast Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Breast Leiomyosarcoma

Genetic Tests for Breast Leiomyosarcoma

Anatomical Context for Breast Leiomyosarcoma

MalaCards organs/tissues related to Breast Leiomyosarcoma:

41
Smooth Muscle, Lung, Skin, Bone, Spleen

Publications for Breast Leiomyosarcoma

Articles related to Breast Leiomyosarcoma:

(show all 34)
# Title Authors Year
1
Primary breast leiomyosarcoma with metastases to the lung in a young adult: Case report and literature review. ( 29705677 )
2018
2
Breast leiomyosarcoma with myxoid aspects. ( 30033605 )
2018
3
Primary breast leiomyosarcoma and synchronous homolateral lung cancer: a case report. ( 29312765 )
2017
4
Primary breast leiomyosarcoma located in the premammary zone: a case report. ( 26278012 )
2015
5
Primary leiomyosarcoma of the breast with prominent osteoclastic giant cells: A case expressing receptor activator of NF-κB ligand (RANKL). ( 26150133 )
2015
6
Twenty-year-old female with leiomyosarcoma of the breast. ( 24876324 )
2014
7
Case Report: Primary Leiomyosarcoma of the breast with unusual metastasis to the femur. ( 25469230 )
2014
8
Primary breast leiomyosarcoma. ( 24455361 )
2013
9
18F-FDG imaging of the primary breast leiomyosarcoma and follow-up lung metastasis. ( 23354027 )
2013
10
Leiomyosarcoma of the breast. ( 24950039 )
2011
11
Primary leiomyosarcoma of the breast. ( 19601949 )
2009
12
Leiomyosarcoma of the breast in a patient with a 10-year-history of cyclophosphamide exposure: a case report. ( 18992149 )
2008
13
Needle aspiration cytology and immunohistologic findings in a case of leiomyosarcoma of the breast. ( 17351941 )
2007
14
Image of the month--leiomyosarcoma of the breast. ( 17178971 )
2006
15
Leiomyosarcoma of the breast: report of a case with fine needle aspiration cytologic, histologic and immunohistochemical features. ( 16450908 )
2005
16
Primitive leiomyosarcoma of the breast: case report and review of the literature. ( 14759721 )
2004
17
A 53-year-old woman with a leiomyosarcoma of the breast. ( 15590026 )
2004
18
Leiomyosarcoma of the breast. A clinicopathologic and immunohistochemical study. ( 12551801 )
2003
19
Leiomyosarcoma of the breast: a difficult diagnosis on fine-needle aspiration biopsy. ( 12951688 )
2003
20
Primary leiomyosarcoma of the breast: a case report with review of the literature. ( 14616945 )
2003
21
Primary leiomyosarcoma of the breast: report of a case. ( 12181723 )
2002
22
Primary leiomyosarcoma of the breast: diagnosis, management and outcome. A report of a new case and review of literature. ( 14965634 )
2001
23
Fine needle aspiration cytodiagnosis of leiomyosarcoma of the breast. A case report. ( 11127743 )
2000
24
Primary leiomyosarcoma of the breast. ( 9413066 )
1997
25
Leiomyosarcoma of the breast. A case report. ( 7631250 )
1995
26
Leiomyosarcoma of the breast; cytological and histological features, with a review of the literature. ( 1421007 )
1992
27
Primary leiomyosarcoma of the breast. ( 1555069 )
1992
28
Primary recurrent leiomyosarcoma of the breast. Case report with ultrastructural and immunohistochemical study and review of the literature. ( 2679042 )
1989
29
Leiomyosarcoma of the breast with late dissemination. ( 6428038 )
1984
30
Primary leiomyosarcoma of the breast. ( 6493566 )
1984
31
Leiomyosarcoma of the breast--a case report and an electron microscopic study. ( 6543377 )
1984
32
Leiomyosarcoma of the breast: a case of long survival and late hepatic metastasis. ( 7194732 )
1981
33
Leiomyosarcoma of the breast originating from myothelium (myoepithelium). ( 4374517 )
1974
34
Leiomyosarcoma of the breast. Report of a case. ( 4414079 )
1974

Variations for Breast Leiomyosarcoma

Expression for Breast Leiomyosarcoma

Search GEO for disease gene expression data for Breast Leiomyosarcoma.

Pathways for Breast Leiomyosarcoma

GO Terms for Breast Leiomyosarcoma

Biological processes related to Breast Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.48 TNFRSF11A TNFSF11
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.46 TNFRSF11A TNFSF11
3 monocyte chemotaxis GO:0002548 9.43 TNFRSF11A TNFSF11
4 osteoclast differentiation GO:0030316 9.4 TNFRSF11A TNFSF11
5 positive regulation of bone resorption GO:0045780 9.37 TNFRSF11A TNFSF11
6 mammary gland alveolus development GO:0060749 9.32 TNFRSF11A TNFSF11
7 paracrine signaling GO:0038001 9.26 CD34 TNFSF11
8 TNFSF11-mediated signaling pathway GO:0071847 9.16 TNFRSF11A TNFSF11
9 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 8.96 TNFRSF11A TNFSF11
10 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.62 TNFRSF11A TNFSF11

Sources for Breast Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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