MCID: BRS043
MIFTS: 29

Breast Leiomyosarcoma

Categories: Cancer diseases

Aliases & Classifications for Breast Leiomyosarcoma

MalaCards integrated aliases for Breast Leiomyosarcoma:

Name: Breast Leiomyosarcoma 12 15 74
Leiomyosarcoma of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5285
NCIt 51 C5186
UMLS 74 C1332631

Summaries for Breast Leiomyosarcoma

Disease Ontology : 12 A breast sarcoma that arises from smooth muscle cells.

MalaCards based summary : Breast Leiomyosarcoma, also known as leiomyosarcoma of the breast, is related to leiomyosarcoma and polyarticular onset juvenile idiopathic arthritis. An important gene associated with Breast Leiomyosarcoma is CHEK2 (Checkpoint Kinase 2), and among its related pathways/superpathways are NF-kappaB Signaling and Osteoclast differentiation. Affiliated tissues include breast, bone and smooth muscle, and related phenotype is neoplasm.

Related Diseases for Breast Leiomyosarcoma

Diseases related to Breast Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 10.3
2 polyarticular onset juvenile idiopathic arthritis 10.1 TNFRSF11A TNFSF11
3 hemophilic arthropathy 10.1 TNFRSF11A TNFSF11
4 osteopetrosis, autosomal recessive 7 10.1 TNFRSF11A TNFSF11
5 osteopetrosis 10.1 TNFRSF11A TNFSF11
6 paget disease of bone 5, juvenile-onset 10.1 TNFRSF11A TNFSF11
7 familial expansile osteolysis 10.1 TNFRSF11A TNFSF11
8 multicentric carpotarsal osteolysis syndrome 10.1 TNFRSF11A TNFSF11
9 osteopetrosis, autosomal recessive 2 10.1 TNFRSF11A TNFSF11
10 aneurysmal bone cysts 10.1 TNFRSF11A TNFSF11
11 periapical periodontitis 10.1 TNFRSF11A TNFSF11
12 tooth resorption 10.1 TNFRSF11A TNFSF11
13 ischemic bone disease 10.0 TNFRSF11A TNFSF11
14 root resorption 10.0 TNFRSF11A TNFSF11
15 bone resorption disease 10.0 TNFRSF11A TNFSF11
16 bone remodeling disease 10.0 TNFRSF11A TNFSF11
17 connective tissue cancer 9.9 CD34 TNFSF11
18 paget's disease of bone 9.9 TNFRSF11A TNFSF11
19 breast myofibroblastoma 9.9 CALD1 CD34
20 intravascular fasciitis 9.9 CALD1 CD34
21 deep leiomyoma 9.9 CALD1 CD34
22 glomangiomyoma 9.9 CALD1 CD34
23 angiomyoma 9.9 CALD1 CD34
24 conventional fibrosarcoma 9.9 CALD1 CD34
25 giant cell tumor 9.9 TNFRSF11A TNFSF11
26 peritoneal benign neoplasm 9.9 CALD1 CD34
27 diffuse peritoneal leiomyomatosis 9.9 CALD1 CD34
28 mesenchymal cell neoplasm 9.9 CALD1 CD34
29 pseudosarcomatous fibromatosis 9.9 CALD1 CD34
30 sarcomatoid squamous cell skin carcinoma 9.8 CALD1 CD34
31 cardiovascular organ benign neoplasm 9.8 CALD1 CD34
32 benign perivascular tumor 9.8 CALD1 CD34
33 skin sarcoma 9.8 CALD1 CD34
34 bone cancer 9.8 TNFRSF11A TNFSF11
35 epithelioid leiomyosarcoma 9.8
36 lung cancer 9.8
37 benign breast phyllodes tumor 9.8
38 nephrogenic adenofibroma 9.8 CALD1 CD34
39 muscle cancer 9.8 CALD1 CD34
40 periodontal disease 9.7 TNFRSF11A TNFSF11

Graphical network of the top 20 diseases related to Breast Leiomyosarcoma:



Diseases related to Breast Leiomyosarcoma

Symptoms & Phenotypes for Breast Leiomyosarcoma

MGI Mouse Phenotypes related to Breast Leiomyosarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 CD34 CHEK2 TNFRSF11A TNFSF11

Drugs & Therapeutics for Breast Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Breast Leiomyosarcoma

Genetic Tests for Breast Leiomyosarcoma

Anatomical Context for Breast Leiomyosarcoma

MalaCards organs/tissues related to Breast Leiomyosarcoma:

42
Breast, Bone, Smooth Muscle, Lung, Skin

Publications for Breast Leiomyosarcoma

Articles related to Breast Leiomyosarcoma:

(show all 42)
# Title Authors Year
1
Primary breast leiomyosarcoma with metastases to the lung in a young adult: Case report and literature review. ( 29705677 )
2018
2
Breast leiomyosarcoma with myxoid aspects. ( 30033605 )
2018
3
Positive response of a primary leiomyosarcoma of the breast following salvage hyperthermia and pazopanib. ( 27079325 )
2018
4
Primary breast leiomyosarcoma and synchronous homolateral lung cancer: a case report. ( 29312765 )
2017
5
Primary breast leiomyosarcoma located in the premammary zone: a case report. ( 26278012 )
2015
6
Primary leiomyosarcoma of the breast with prominent osteoclastic giant cells: A case expressing receptor activator of NF-κB ligand (RANKL). ( 26150133 )
2015
7
Twenty-year-old female with leiomyosarcoma of the breast. ( 24876324 )
2014
8
Case Report: Primary Leiomyosarcoma of the breast with unusual metastasis to the femur. ( 25469230 )
2014
9
18F-FDG imaging of the primary breast leiomyosarcoma and follow-up lung metastasis. ( 23354027 )
2013
10
Primary breast leiomyosarcoma. ( 24455361 )
2013
11
Primary leiomyosarcoma of the breast: a case report. ( 22493639 )
2012
12
Primary leiomyosarcoma of the breast. ( 22060672 )
2012
13
Leiomyosarcoma of the breast: a case report and review of the literature about therapeutic management. ( 21530255 )
2011
14
Leiomyosarcoma of the breast. ( 24950039 )
2011
15
Primary leiomyosarcoma of the breast treated by partial resection of the breast including nipple and areola: report of a case. ( 21046506 )
2010
16
Primary leiomyosarcoma of the breast: A case report and review of literature. ( 23133273 )
2010
17
Primary leiomyosarcoma of the breast. ( 19601949 )
2009
18
Leiomyosarcoma of the breast in a patient with a 10-year-history of cyclophosphamide exposure: a case report. ( 18992149 )
2008
19
Needle aspiration cytology and immunohistologic findings in a case of leiomyosarcoma of the breast. ( 17351941 )
2007
20
Image of the month--leiomyosarcoma of the breast. ( 17178971 )
2006
21
Leiomyosarcoma of the breast: report of a case with fine needle aspiration cytologic, histologic and immunohistochemical features. ( 16450908 )
2005
22
A 53-year-old woman with a leiomyosarcoma of the breast. ( 15590026 )
2004
23
Primitive leiomyosarcoma of the breast: case report and review of the literature. ( 14759721 )
2004
24
Leiomyosarcoma of the breast: a pathologic and comparative genomic hybridization study of two cases. ( 15104283 )
2004
25
Leiomyosarcoma of the breast: a difficult diagnosis on fine-needle aspiration biopsy. ( 12951688 )
2003
26
Primary leiomyosarcoma of the breast: a case report with review of the literature. ( 14616945 )
2003
27
Leiomyosarcoma of the breast. A clinicopathologic and immunohistochemical study. ( 12551801 )
2003
28
Primary leiomyosarcoma of the breast: report of a case. ( 12181723 )
2002
29
Primary leiomyosarcoma of the breast: diagnosis, management and outcome. A report of a new case and review of literature. ( 14965634 )
2001
30
Fine needle aspiration cytodiagnosis of leiomyosarcoma of the breast. A case report. ( 11127743 )
2000
31
Primary leiomyosarcoma of the breast. ( 9413066 )
1997
32
Leiomyosarcoma of the breast. A case report. ( 7631250 )
1995
33
Epithelioid leiomyosarcoma of the breast: report of a case. ( 8104588 )
1993
34
Leiomyosarcoma of the breast; cytological and histological features, with a review of the literature. ( 1421007 )
1992
35
Primary leiomyosarcoma of the breast. ( 1555069 )
1992
36
Primary recurrent leiomyosarcoma of the breast. Case report with ultrastructural and immunohistochemical study and review of the literature. ( 2679042 )
1989
37
Leiomyosarcoma of the breast with late dissemination. ( 6428038 )
1984
38
Primary leiomyosarcoma of the breast. ( 6493566 )
1984
39
Leiomyosarcoma of the breast--a case report and an electron microscopic study. ( 6543377 )
1984
40
Leiomyosarcoma of the breast: a case of long survival and late hepatic metastasis. ( 7194732 )
1981
41
Leiomyosarcoma of the breast originating from myothelium (myoepithelium). ( 4374517 )
1974
42
Leiomyosarcoma of the breast. Report of a case. ( 4414079 )
1974

Variations for Breast Leiomyosarcoma

Expression for Breast Leiomyosarcoma

Search GEO for disease gene expression data for Breast Leiomyosarcoma.

Pathways for Breast Leiomyosarcoma

GO Terms for Breast Leiomyosarcoma

Biological processes related to Breast Leiomyosarcoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.49 TNFRSF11A TNFSF11
2 ossification GO:0001503 9.48 TNFRSF11A TNFSF11
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.46 TNFRSF11A TNFSF11
4 monocyte chemotaxis GO:0002548 9.43 TNFRSF11A TNFSF11
5 osteoclast differentiation GO:0030316 9.4 TNFRSF11A TNFSF11
6 positive regulation of bone resorption GO:0045780 9.37 TNFRSF11A TNFSF11
7 mammary gland alveolus development GO:0060749 9.32 TNFRSF11A TNFSF11
8 paracrine signaling GO:0038001 9.26 CD34 TNFSF11
9 TNFSF11-mediated signaling pathway GO:0071847 9.16 TNFRSF11A TNFSF11
10 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 8.96 TNFRSF11A TNFSF11
11 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.62 TNFRSF11A TNFSF11

Sources for Breast Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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