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MCID: BRS022
MIFTS: 25

Breast Liposarcoma

Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Breast Liposarcoma

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MalaCards integrated aliases for Breast Liposarcoma:

Name: Breast Liposarcoma 12 15 71
Liposarcoma of the Breast 12

Classifications:

MalaCards categories:
Global: Cancer diseases
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External Ids:

Disease Ontology 12 DOID:5701
NCIt 49 C5187
UMLS 71 C1332632
Sources

Summaries for Breast Liposarcoma

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Disease Ontology : 12 A breast sarcoma that arises from fat cells.

MalaCards based summary : Breast Liposarcoma, also known as liposarcoma of the breast, is related to histiocytoma and leiomyosarcoma. An important gene associated with Breast Liposarcoma is RBM15 (RNA Binding Motif Protein 15), and among its related pathways/superpathways is Notch-mediated HES/HEY network. Affiliated tissues include breast, liver and brain, and related phenotypes are craniofacial and growth/size/body region

Sources

Related Diseases for Breast Liposarcoma

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Diseases related to Breast Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 histiocytoma 29.2 ENO2 CDK4
2 leiomyosarcoma 28.5 ENO2 CDK4
3 liposarcoma 10.3
4 myxoid liposarcoma 10.2
5 pleomorphic liposarcoma 10.2
6 benign breast phyllodes tumor 10.1
7 heart septal defect 9.9 TBX3 NOTCH1
8 carcinoid tumors, intestinal 9.9 NOTCH1 ENO2
9 breast cancer 9.9
10 li-fraumeni syndrome 9.9
11 chondrosarcoma 9.9
12 osteogenic sarcoma 9.9
13 li-fraumeni syndrome 2 9.9
14 ductal carcinoma in situ 9.9
15 ptosis 9.9
16 breast abscess 9.9
17 rhabdomyosarcoma 9.9
18 cellular myxoid liposarcoma 9.9
19 adenoma 9.9
20 bilateral breast cancer 9.9
21 in situ carcinoma 9.9
22 47,xyy 9.9
23 angiosarcoma 9.9
24 breast fibroadenoma 9.9
25 malignant fibroxanthoma 9.9
26 fibrosarcoma 9.9
27 fibrous histiocytoma 9.9
28 well-differentiated liposarcoma 9.9
29 spindle cell liposarcoma 9.9
30 undifferentiated pleomorphic sarcoma 9.9
31 esophageal atresia 9.8 NOTCH1 ENO2
32 adult liposarcoma 9.7 NOTCH1 CDK4
33 paratesticular lipoma 9.7 ENO2 CDK4
34 lipoma of spermatic cord 9.6 ENO2 CDK4
35 connective tissue benign neoplasm 9.6 ENO2 CDK4
36 wilms tumor 1 9.6 RBM15 NOTCH1 ENO2
37 muscle cancer 9.5 ENO2 CDK4
38 rhabdomyosarcoma 2 9.5 ENO2 CDK4
39 tetralogy of fallot 9.5 TBX3 NOTCH1 ENO2
40 inflammatory myofibroblastic tumor 9.5 ENO2 CDK4
41 large cell carcinoma 9.4 ENO2 CDK4
42 dermatofibrosarcoma protuberans 9.4 ENO2 CDK4
43 retinal cancer 9.4 TCHP CDK4
44 suppression of tumorigenicity 12 9.2 NOTCH1 ENO2 CDK4
45 muscular disease 9.1 NOTCH1 ENO2 CDK4
46 leukemia, acute myeloid 9.0 TCHP RBM15 NOTCH1 CDK4
47 neuroblastoma 8.9 RBM15 NOTCH1 ENO2 CDK4
48 brain cancer 8.3 TBX3 SPEN RBM15 NOTCH1 ENO2 CDK4

Graphical network of the top 20 diseases related to Breast Liposarcoma:



Diseases related to Breast Liposarcoma
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Symptoms & Phenotypes for Breast Liposarcoma

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MGI Mouse Phenotypes related to Breast Liposarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.55 CDK4 ENO2 NOTCH1 TBX3 TCHP
2 growth/size/body region MP:0005378 9.43 CDK4 ENO2 NOTCH1 SPEN TBX3 TCHP
3 liver/biliary system MP:0005370 8.92 CDK4 NOTCH1 SPEN TBX3
Sources

Drugs & Therapeutics for Breast Liposarcoma

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Search Clinical Trials , NIH Clinical Center for Breast Liposarcoma

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Genetic Tests for Breast Liposarcoma

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Anatomical Context for Breast Liposarcoma

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MalaCards organs/tissues related to Breast Liposarcoma:

40
Breast, Liver, Brain, Heart, Myeloid
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Publications for Breast Liposarcoma

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Articles related to Breast Liposarcoma:

(show all 40)
# Title Authors PMID Year
1
Primary Breast Liposarcoma. 61
31565160 2018
2
Well-differentiated liposarcoma of the breast arising in a background of malignant phyllodes tumor in a pregnant woman: A rare case report and review of literature. 61
30303154 2018
3
Metaplastic Breast Cancer Masquerading as Liposarcoma of the Breast: A Case Report following Oncoplastic Treatment. 61
29788010 2018
4
Breast liposarcoma with solitary metastasis to the pleura: A case report. 61
28682882 2017
5
Liposarcoma of the breast arising in a malignant phyllodes tumor: A case report and review of the literature. 61
26468454 2015
6
Primary well differentiated breast liposarcoma with divergent cartilagenous differentiation: a case report. 61
23599887 2013
7
A case of myxoid liposarcoma of the breast. 61
23826427 2013
8
Lipoprotein lipase links dietary fat to solid tumor cell proliferation. 61
21282354 2011
9
Primary pleomorphic liposarcoma of breast: a rare case report. 61
21393893 2011
10
[Breast liposarcoma]. 61
21384685 2010
11
Pleomorphic liposarcoma of the breast mimicking breast abscess in a 19-year-old postpartum female: a case report and review of the literature. 61
20604797 2010
12
Myxoid liposarcoma of the breast in a 25-year-old female as a diagnostic pitfall in fine needle aspiration cytology: report of a rare case. 61
18677756 2008
13
An unusual case of breast liposarcoma with liver metastases: the role of radical surgery. 61
17461917 2007
14
Liposarcoma of the breast--a case report. 61
17966230 2007
15
Myxoid liposarcoma of the breast--report of a rare case. 61
17001892 2006
16
Liposarcoma of the breast: a case report and review of the literature. 61
12403092 2002
17
Fine needle aspiration of pleomorphic liposarcoma of the breast: revised diagnosis. 61
11726108 2001
18
Fine needle aspiration of primary pleomorphic liposarcoma of the breast. A case report. 61
10578991 1999
19
Liposarcoma of the breast arising within a phyllodes tumor. 61
10524864 1999
20
[Liposarcoma of the breast. A case report]. 61
9599769 1998
21
[Bilateral breast carcinoma after recurrent myxoid liposarcoma of the breast]. 61
7792276 1995
22
Fine needle aspiration cytology of liposarcoma of the breast. A case report. 61
7992586 1994
23
Bilateral liposarcoma of the breast. 61
8338489 1993
24
Liposarcoma of the breast: a clinicopathologic study of 20 cases. 61
3019868 1986
25
[5 cases of liposarcoma of the breast in women]. 61
3788153 1986
26
[Liposarcoma of the breast]. 61
7166272 1982
27
Liposarcoma: the Manitoba experience. 61
7272854 1981
28
[Myxoid liposarcoma of the breast]. 61
7271948 1981
29
Liposarcoma of the breast, review of the literature and a report of a case. 61
7311199 1981
30
Liposarcoma of the breast--fine structural and histochemical study of a case and review of 42 cases in the literature. 61
6454988 1980
31
Liposarcoma of the breast: a case report. 61
7228562 1980
32
Liposarcoma of the breast. Case report and review of the literature. 61
162097 1979
33
Case report: Liposarcoma of the breast. 61
750471 1978
34
Liposarcoma of the breast. A case report. 61
696158 1978
35
Liposarcoma of the breast. A case report. 61
4424109 1974
36
Liposarcoma of the breast. A case of bilateral involvement. 61
6023033 1967
37
Metastasising liposarcoma of the breast arising in a fibro-adenoma. 61
14450565 1962
38
Liposarcoma of the Breast: Case Report and Review of Literature. 61
20326226 1960
39
Liposarcoma of the breast. 61
13510670 1957
40
Liposarcoma of the breast; report of a case. 61
13197323 1954
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Variations for Breast Liposarcoma

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Expression for Breast Liposarcoma

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Search GEO for disease gene expression data for Breast Liposarcoma.
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Pathways for Breast Liposarcoma

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Pathways related to Breast Liposarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Notch-mediated HES/HEY network 1
10.3 SPEN NOTCH1
Sources

GO Terms for Breast Liposarcoma

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Biological processes related to Breast Liposarcoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 heart looping GO:0001947 9.49 TBX3 NOTCH1
2 outflow tract morphogenesis GO:0003151 9.48 TBX3 NOTCH1
3 animal organ regeneration GO:0031100 9.46 NOTCH1 CDK4
4 positive regulation of cell cycle GO:0045787 9.43 TBX3 CDK4
5 regulation of cell proliferation GO:0042127 9.43 TBX3 NOTCH1 CDK4
6 cell fate specification GO:0001708 9.4 TBX3 NOTCH1
7 embryonic hindlimb morphogenesis GO:0035116 9.37 TBX3 NOTCH1
8 negative regulation of myoblast differentiation GO:0045662 9.32 TBX3 NOTCH1
9 negative regulation of transcription, DNA-templated GO:0045892 9.26 TBX3 SPEN RBM15 NOTCH1
10 positive regulation of transcription of Notch receptor target GO:0007221 9.16 RBM15 NOTCH1
11 ventricular septum morphogenesis GO:0060412 8.8 TBX3 RBM15 NOTCH1

Molecular functions related to Breast Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor binding GO:0001085 8.62 TBX3 SPEN
Sources

Sources for Breast Liposarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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