MCID: BRS001
MIFTS: 37

Breast Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Breast Lymphoma

MalaCards integrated aliases for Breast Lymphoma:

Name: Breast Lymphoma 12 15 70
Malignant Lymphoma of Breast 12
Lymphoma of the Breast 12
Lymphoma of Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5826
SNOMED-CT 67 278052009
UMLS 70 C0349669 C1704251

Summaries for Breast Lymphoma

Disease Ontology : 12 A breast cancer that arises from lymphocytes.

MalaCards based summary : Breast Lymphoma, also known as malignant lymphoma of breast, is related to lymphoma, hodgkin, classic and lymphoma. An important gene associated with Breast Lymphoma is IRF4 (Interferon Regulatory Factor 4), and among its related pathways/superpathways are B cell receptor signaling pathway (KEGG) and NF-kappaB Signaling. The drugs Pembrolizumab and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and bone marrow, and related phenotype is immune system.

Related Diseases for Breast Lymphoma

Diseases related to Breast Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)
# Related Disease Score Top Affiliating Genes
1 lymphoma, hodgkin, classic 30.2 TNFRSF8 IRF4 BCL6 ALK
2 lymphoma 30.2 TNFRSF8 IRF4 CD5 BCL6 ALK
3 intravascular large b-cell lymphoma 30.1 MME CD5 BCL6
4 lymphosarcoma 30.0 TNFRSF8 BCL6
5 primary cutaneous anaplastic large cell lymphoma 30.0 IRF4 ALK
6 alk-positive anaplastic large cell lymphoma 30.0 TNFRSF8 ALK
7 reticulum cell sarcoma 30.0 TNFRSF8 CD2
8 breast implant-associated anaplastic large cell lymphoma 30.0 TNFRSF8 ALK
9 t-cell lymphoma, subcutaneous panniculitis-like 29.9 TNFRSF8 ALK
10 hodgkin's lymphoma, lymphocytic-histiocytic predominance 29.9 TNFRSF8 BCL6
11 extramedullary plasmacytoma 29.9 IRF4 CD79A
12 follicular lymphoma 29.8 MME IRF4 CD5 BCL6
13 b-cell lymphoma 29.8 TNFRSF8 MME IRF4 CD5 BCL6 ALK
14 lymphoblastic lymphoma 29.7 TNFRSF8 MME CD5 BCL6
15 burkitt lymphoma 29.7 TNFRSF8 MME IRF4 BCL6
16 plasmacytoma 29.6 IRF4 CD79A CD5
17 hematologic cancer 29.6 TNFRSF8 IRF4 ALK
18 cryoglobulinemia 29.5 CD79A CD5
19 reticulosarcoma 29.5 TNFRSF8 BCL6 ALK
20 peripheral t-cell lymphoma 29.2 TNFRSF8 MME CD5 BCL6 ALK
21 histiocytosis 29.2 TNFRSF8 ALK
22 lymphoplasmacytic lymphoma 29.1 MME CD79A CD5 BCL6
23 myeloid sarcoma 29.1 SPN IRF4 CD79A
24 nodal marginal zone lymphoma 28.8 SPN MME IRF4 CD5 BCL6
25 mantle cell lymphoma 28.8 SPN MME CD5 BCL6
26 diffuse large b-cell lymphoma 28.6 TNFRSF8 SPN MME IRF4 CD79A CD5
27 marginal zone b-cell lymphoma 28.4 TNFRSF8 SPN MME IRF4 CD79A CD5
28 lymphoma, non-hodgkin, familial 28.4 TNFRSF8 SPN MME IRF4 CD79A CD5
29 lymphoma, mucosa-associated lymphoid type 28.3 TNFRSF8 SPN MME IRF4 CD79A CD5
30 mature t-cell and nk-cell lymphoma 27.9 TNFRSF8 MME CD79A CD5 CD2 BCL6
31 leukemia, acute myeloid 27.5 TNFRSF8 SPN MME CD79A CD5 CD2
32 primary mediastinal large b-cell lymphoma 10.2 IRF4 BCL6
33 amyloidosis 10.2
34 adult acute lymphocytic leukemia 10.2 TNFRSF8 CD2
35 retroperitoneal lymphoma 10.2 TNFRSF8 MME
36 thyrotoxic exophthalmos 10.2 MME CD5
37 eye lymphoma 10.2 CD5 BCL6
38 endocrine exophthalmos 10.2 MME CD5
39 orbital cellulitis 10.1 TNFRSF8 MME
40 acute orbital inflammation 10.1 TNFRSF8 MME
41 chest wall lymphoma 10.1 MME BCL6
42 ovarian lymphoma 10.1 MME BCL6
43 breast lipoma 10.1 TNFRSF8 ALK
44 central epithelioid sarcoma 10.1 TNFRSF8 MME
45 vulvar proximal-type epithelioid sarcoma 10.1 TNFRSF8 MME
46 rare tumor 10.1
47 pleural lipoma 10.1 TNFRSF8 ALK
48 lymphomatoid papulosis 10.1 TNFRSF8 ALK
49 pilar sheath acanthoma 10.1 TNFRSF8 MME
50 hodgkin's lymphoma, lymphocytic depletion 10.1 TNFRSF8 CD79A

Graphical network of the top 20 diseases related to Breast Lymphoma:



Diseases related to Breast Lymphoma

Symptoms & Phenotypes for Breast Lymphoma

MGI Mouse Phenotypes related to Breast Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 BCL6 CD5 CD79A IRF4 MME SPN

Drugs & Therapeutics for Breast Lymphoma

Drugs for Breast Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
2
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
3 Flt3 ligand protein Phase 1, Phase 2
4 Mitogens Phase 1, Phase 2
5 Pharmaceutical Solutions Phase 1, Phase 2
6 Poly ICLC Phase 1, Phase 2
7 Immunosuppressive Agents Phase 1, Phase 2
8 Immunoglobulins Phase 1, Phase 2
9 Vaccines Phase 1, Phase 2
10 Alkylating Agents Phase 1, Phase 2
11 Immunoglobulin G Phase 1, Phase 2
12 Immunoglobulins, Intravenous Phase 1, Phase 2
13 interferons Phase 1, Phase 2
14 Interferon-alpha Phase 1, Phase 2
15 Antibodies Phase 1, Phase 2
16 Interferon alpha-2 Phase 1, Phase 2
17
Proline Nutraceutical Phase 1, Phase 2 147-85-3 145742
18
Aldesleukin Approved Phase 1 110942-02-4, 85898-30-2
19
Lenograstim Approved, Investigational Phase 1 135968-09-1
20 Antiviral Agents Phase 1
21 Anti-Infective Agents Phase 1
22 Anti-Retroviral Agents Phase 1
23 Anti-HIV Agents Phase 1
24
rituximab Approved 174722-31-7 10201696
25 Antirheumatic Agents
26 Antineoplastic Agents, Immunological
27 Immunologic Factors

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 In Situ Vaccination With Flt3L, Radiation, and Poly-ICLC Combined With Pembrolizumab in Patients With Non-Hodgkin's Lymphoma, Metastatic Breast Cancer, and Head and Neck Squamous Cell Carcinoma Recruiting NCT03789097 Phase 1, Phase 2 Pembrolizumab;Flt3L;Poly ICLC
2 A Randomized, Open Label Pilot Trial of a Biomarker Guided Strategy of Cardioprotection in Patients With Lymphoma or Breast Cancer Treated With Anthracyclines Recruiting NCT04737265 Phase 1, Phase 2
3 A Phase I/II Study of the SV-BR-1-GM Regimen in HLA Matched Metastatic Breast Cancer Patients in Combination With Pembrolizumab Not yet recruiting NCT04418219 Phase 1, Phase 2 Cyclophosphamide
4 A Phase 1, Open-Label, Dose Escalation and Dose Expansion Trial Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Effects of Orally Administered CA-170 in Patients With Advanced Tumors and Lymphomas Completed NCT02812875 Phase 1 CA-170
5 Immunotherapy With Subcutaneous Il-2 and Stem Cell Factor (SCF) for Patients With Lymphoma or Breast Cancer After Autologous Transplantation Terminated NCT00005993 Phase 1 aldesleukin;filgrastim;recombinant human stem cell factor
6 Pilot Survey to Assess International Travel Patterns and Risk Behaviour of Breast Cancer, Lymphoma Patients and Bone Marrow Transplant Recipients at Memorial Sloan-Kettering Cancer Center Completed NCT01111201
7 Breast Implant-associated Anaplastic Large Cell Lymphoma (BIA-ALCL) Registry Recruiting NCT04220970
8 Improving Exercise Capacity With a Tailored Physical Activity Intervention in Lymphoma and Breast Cancer Patients Undergoing Treatment - An Addendum to NIH R01CA167821 "Early Imaging Detection of Cardiovascular Injury After Cancer" Recruiting NCT01719562
9 Improving Exercise Capacity With a Tailored Physical Activity Intervention in Lymphoma and Breast Cancer Patients Undergoing Treatment Recruiting NCT03923504
10 A Prospective Observational Study of Newly Diagnosed Diffuse Large B Cell Primary Breast Lymphomas Treated With R-CHOP With or Without Radiotherapy Terminated NCT01279772
11 A Prospective Observational Study of Newly Diagnosed Diffuse Large B Cell Primary Breast Lymphomas Treated With RCHOP With or Without Radiotherapy Terminated NCT01144754 Rituximab

Search NIH Clinical Center for Breast Lymphoma

Genetic Tests for Breast Lymphoma

Anatomical Context for Breast Lymphoma

MalaCards organs/tissues related to Breast Lymphoma:

40
Breast, Lung, Bone Marrow, Bone, Liver, Myeloid, Lymph Node

Publications for Breast Lymphoma

Articles related to Breast Lymphoma:

(show top 50) (show all 361)
# Title Authors PMID Year
1
Epidemiological features of primary breast lymphoma patients and development of a nomogram to predict survival. 61
33774459 2021
2
Lymphoma of the breast: A clinicopathologic analysis of 51 cases with a specific emphasis on patients with a history of breast carcinoma. 61
33578453 2021
3
Incidentally detected Non-Hodgkin's lymphoma of the breast. A case report with review of literature. 61
33294090 2021
4
Comparison of Clinical Features Between Primary and Secondary Breast Diffuse Large B Cell Lymphoma: A Yokohama Cooperative Study Group for Hematology Multicenter Retrospective Study. 61
33707836 2021
5
It's Not Always Gynecomastia: A Case of Diffuse Large B-Cell Lymphoma Presenting as Breast Mass in a Male Patient. 61
33654621 2021
6
Primary lymphoma of the breast: A case report and review of the literature. 61
33193929 2021
7
Case 285: Primary Breast Lymphoma. 61
33347397 2021
8
Chromosomes in breast lymphoma. 61
33331930 2020
9
Primary lymphoma of the breast: A report of two cases. 61
32961512 2020
10
Primary Breast Extranodal Marginal Zone Lymphoma in Primary Sjögren Syndrome: Case Presentation and Relevant Literature. 61
33321727 2020
11
CD10-Negative Primary Breast Follicular Lymphoma: A Rare Case of Primary Breast Lymphoma With an Atypical Immunophenotype Mimicking Marginal Zone Lymphoma. 61
33252276 2020
12
Combination of baseline total metabolic tumor volume measured on FDG-PET/CT and β2-microglobulin have a robust predictive value in patients with primary breast lymphoma. 61
32533716 2020
13
First-in-Human Trial of Epichaperome-Targeted PET in Patients with Cancer. 61
32366671 2020
14
Primary and Secondary Breast Lymphoma: Focus on Epidemiology and Imaging Features. 61
31428995 2020
15
Clinical Characteristics and Outcomes of Primary Breast Lymphoma: The Cleveland Clinic Experience. 61
32676248 2020
16
Ultrasound Diagnosis of Breast Lymphoma and the Identification of Breast Infiltrating Ductal Carcinoma. 61
31891216 2020
17
PRIMARY HODGKIN'S LYMPHOMA OF THE BREAST INITIALLY TREATED BY SURGICAL EXCISION AND AXILLARY DISSECTION. 61
33456126 2020
18
Primary breast non-Hodgkin's lymphoma in a 14-year-old girl: a case report. 61
32350630 2020
19
[Primary diffuse large B-cell lymphoma of the breast in a male patient with Sjögren's syndrome]. 61
33298650 2020
20
Primary breast lymphoma. 61
31976067 2020
21
Radiomics based on 18 F-FDG PET/CT could differentiate breast carcinoma from breast lymphoma using machine-learning approach: A preliminary study. 61
31769230 2020
22
Male breast involvement in chronic lymphocytic leukemia. A case report and review of the literature. 61
32747916 2020
23
Radiological analysis of breast lymphoma: Experiences from cases series studies. 61
31770231 2019
24
Primary breast lymphoma in a male patient. 61
31130495 2019
25
Primary bilateral breast lymphoma in an elder male patient. 61
31187574 2019
26
Incidental Primary Breast Lymphoma on 99mTc-Sestamibi Myocardial Perfusion Imaging With SPECT/CT. 61
31274632 2019
27
Potential role of abbreviated MRI for breast cancer screening in an academic medical center. 61
31206889 2019
28
Primary and Secondary Breast Lymphoma: Clinical, Pathologic, and Multimodality Imaging Review. 61
30924754 2019
29
Breast Lymphoma: Teaching point: Primary breast lymphoma is a rare disease, especially in males, but should be considered in the differential diagnosis of a breast mass because of the different treatment and prognosis. 61
30993257 2019
30
Adult height in relation to risk of cancer in a cohort of 22,809,722 Korean adults. 61
30778143 2019
31
In Vitro Cytotoxicity and Interaction of Noscapine with Human Serum Albumin: Effect on Structure and Esterase Activity of HSA. 61
30629454 2019
32
Do doctors who order more routine medical tests diagnose more cancers? A population-based study from Ontario Canada. 61
30609320 2019
33
Primary breast lymphoma: A single-centre experience. 61
32721093 2019
34
Cancer and Aging: Reflections for Elders (CARE): A pilot randomized controlled trial of a psychotherapy intervention for older adults with cancer. 61
30296337 2019
35
Ability of 18F-FDG PET/CT Radiomic Features to Distinguish Breast Carcinoma from Breast Lymphoma. 61
30930700 2019
36
Lymphoepithelioma-like carcinoma of breast: A case report and review of the literature. 61
30706876 2019
37
Multimodality imaging features of primary breast lymphoma - A rare entity. 61
31000948 2019
38
Primary diffuse large B-cell non-Hodgkin's lymphoma of the breast-A case report and review of the literature. 61
30305860 2019
39
Methotrexate (MTX)-associated malignant lymphoma of the bilateral breast: imaging features in comparison to other nipple-areolar tumors. 61
30340074 2019
40
[Clinicopathologic features of breast lymphoma in core needle biopsy]. 61
30317726 2018
41
Development of a new high-affinity human antibody with antitumor activity against solid and blood malignancies. 61
29913558 2018
42
Primary lymphoma of the breast: A case series. 61
29988973 2018
43
Management and outcomes of women diagnosed with primary breast lymphoma: a multi-institution experience. 61
29356916 2018
44
Breast lymphoma occurring after an invasive ductal breast carcinoma developed in the same area: A case report and literature review. 61
29657120 2018
45
Breast Implants and the Risk of Anaplastic Large-Cell Lymphoma in the Breast. 61
29302687 2018
46
Coincident primary breast lymphoma and gastrointestinal stromal tumor: case series and molecular mechanisms. 61
30573980 2018
47
Primary breast lymphoma: A mimic of inflammatory breast cancer. 61
30567057 2018
48
Present and Future Prospect of Small Molecule & Related Targeted Therapy Against Human Cancer. 61
30853755 2018
49
Lymphoma Involving Skin and Subcutaneous Fat of the Breast: Two Cases. 61
29189695 2017
50
Role of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography in evaluating breast mucosa-associated lymphoid tissue lymphoma: A case series. 61
28004400 2017

Variations for Breast Lymphoma

Expression for Breast Lymphoma

Search GEO for disease gene expression data for Breast Lymphoma.

Pathways for Breast Lymphoma

GO Terms for Breast Lymphoma

Cellular components related to Breast Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.35 SPN MME CD5 CD2 ALK
2 membrane raft GO:0045121 9.33 MME CD79A CD2
3 external side of plasma membrane GO:0009897 8.92 SPN CD79A CD5 CD2

Biological processes related to Breast Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.56 PIBF1 IRF4 CD79A BCL6
2 cell surface receptor signaling pathway GO:0007166 9.5 SPN CD79A CD2
3 T cell activation GO:0042110 9.16 IRF4 CD2
4 positive regulation of interleukin-10 production GO:0032733 8.96 PIBF1 IRF4
5 positive regulation of tumor necrosis factor production GO:0032760 8.8 TNFRSF8 SPN CD2

Molecular functions related to Breast Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 PIBF1 CD79A CD2 BCL6 ALK
2 transmembrane signaling receptor activity GO:0004888 8.8 TNFRSF8 SPN CD79A

Sources for Breast Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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