MCID: BRS001
MIFTS: 35

Breast Lymphoma

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Breast Lymphoma

MalaCards integrated aliases for Breast Lymphoma:

Name: Breast Lymphoma 12 15 74
Malignant Lymphoma of Breast 12
Lymphoma of the Breast 12
Lymphoma of Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5826

Summaries for Breast Lymphoma

Disease Ontology : 12 A breast cancer that arises_from lymphocytes.

MalaCards based summary : Breast Lymphoma, also known as malignant lymphoma of breast, is related to intravascular large b-cell lymphoma and follicular lymphoma. An important gene associated with Breast Lymphoma is PIBF1 (Progesterone Immunomodulatory Binding Factor 1), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. The drugs rituximab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include breast, b cells and t cells, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and immune system

Related Diseases for Breast Lymphoma

Diseases related to Breast Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 intravascular large b-cell lymphoma 29.6 BCL6 CD5 MME
2 follicular lymphoma 29.2 BCL6 MME
3 cryoglobulinemia 29.2 CD5 CD79A
4 mantle cell lymphoma 29.2 BCL6 CD5 MME
5 b-cell lymphomas 29.2 BCL6 CD5 MME
6 marginal zone b-cell lymphoma 29.2 BCL6 CD5 CD79A MME
7 lymphoblastic lymphoma 29.2 BCL6 CD5 MME
8 lymphoma, mucosa-associated lymphoid type 28.7 BCL6 CD5 CD79A MME
9 diffuse large b-cell lymphoma 28.6 BCL6 CD5 CD79A MME
10 peripheral t-cell lymphoma 28.5 ALK BCL6 CD5 MME
11 lymphoma, hodgkin, classic 28.0 ALK BCL6 CD5 CD79A MME
12 lymphoma, non-hodgkin, familial 27.9 ALK BCL6 CD5 CD79A MME
13 lymphoma 10.7
14 breast cancer 10.1
15 heart lymphoma 10.1 BCL6 MME
16 testicular lymphoma 10.1 BCL6 MME
17 composite lymphoma 10.1 BCL6 CD5
18 t-cell/histiocyte rich large b cell lymphoma 10.1 BCL6 MME
19 tracheal lymphoma 10.1 CD5 MME
20 epidural neoplasm 10.0 BCL6 CD5
21 central nervous system hematologic cancer 10.0 BCL6 MME
22 cll/sll 10.0 CD5 MME
23 plasma protein metabolism disease 10.0 CD5 MME
24 burkitt lymphoma 10.0
25 angioimmunoblastic t-cell lymphoma 10.0 BCL6 MME
26 mediastinal cancer 10.0 CD5 CD79A
27 splenic marginal zone lymphoma 10.0 BCL6 CD5
28 ileum cancer 9.9 CD5 MME
29 mediastinal malignant lymphoma 9.9 BCL6 CD79A
30 nodal marginal zone lymphoma 9.9
31 amyloidosis 9.9
32 anaplastic large cell lymphoma 9.8
33 alk-negative anaplastic large cell lymphoma 9.8
34 adult lymphoma 9.8 ALK CD5
35 hodgkin's lymphoma, lymphocytic depletion 9.8 ALK CD79A
36 rheumatoid arthritis 9.8
37 sjogren syndrome 9.8
38 arthritis 9.8
39 mastitis 9.8
40 infant gynecomastia 9.8
41 gynecomastia 9.8
42 reticulosarcoma 9.7 ALK BCL6
43 lymphosarcoma 9.7 BCL6 CD5 CD79A
44 mature b-cell neoplasm 9.7 BCL6 CD79A MME
45 bladder lymphoma 9.7 CD5 CD79A MME
46 t-cell lymphoma, subcutaneous panniculitis-like 9.7
47 leukemia 9.7
48 ductal carcinoma in situ 9.7
49 breast abscess 9.7
50 panniculitis 9.7

Graphical network of the top 20 diseases related to Breast Lymphoma:



Diseases related to Breast Lymphoma

Symptoms & Phenotypes for Breast Lymphoma

GenomeRNAi Phenotypes related to Breast Lymphoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.8 BCL6 CD79A MME

MGI Mouse Phenotypes related to Breast Lymphoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 8.92 BCL6 CD5 CD79A MME

Drugs & Therapeutics for Breast Lymphoma

Drugs for Breast Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved 174722-31-7 10201696
2 Antineoplastic Agents, Immunological
3 Immunologic Factors
4 Antirheumatic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 This Trial is a Prospective Observational Study of Newly Diagnosed Diffuse Large B Cell Primary Breast Lymphomas Terminated NCT01279772
2 Observational Study of Diffuse Large B Cell Primary Breast Lymphomas Treated With RCHOP +/- XRT Terminated NCT01144754 Rituximab

Search NIH Clinical Center for Breast Lymphoma

Genetic Tests for Breast Lymphoma

Anatomical Context for Breast Lymphoma

MalaCards organs/tissues related to Breast Lymphoma:

42
Breast, B Cells, T Cells, Bone, Lymph Node, Bone Marrow, Skin

Publications for Breast Lymphoma

Articles related to Breast Lymphoma:

(show top 50) (show all 153)
# Title Authors Year
1
Primary and Secondary Breast Lymphoma: Clinical, Pathologic, and Multimodality Imaging Review. ( 30924754 )
2019
2
Ability of 18F-FDG PET/CT Radiomic Features to Distinguish Breast Carcinoma from Breast Lymphoma. ( 30930700 )
2019
3
Incidental Primary Breast Lymphoma on 99mTc-Sestamibi Myocardial Perfusion Imaging with SPECT/CT. ( 30985423 )
2019
4
Breast Lymphoma: Teaching point: Primary breast lymphoma is a rare disease, especially in males, but should be considered in the differential diagnosis of a breast mass because of the different treatment and prognosis. ( 30993257 )
2019
5
Multimodality imaging features of primary breast lymphoma - A rare entity. ( 31000948 )
2019
6
Management and outcomes of women diagnosed with primary breast lymphoma: a multi-institution experience. ( 29356916 )
2018
7
Breast lymphoma occurring after an invasive ductal breast carcinoma developed in the same area: A case report and literature review. ( 29657120 )
2018
8
Primary breast lymphoma: A mimic of inflammatory breast cancer. ( 30567057 )
2018
9
Coincident primary breast lymphoma and gastrointestinal stromal tumor: case series and molecular mechanisms. ( 30573980 )
2018
10
Primary Breast Lymphoma: Analysis of 55 Cases of the Spanish Lymphoma Oncology Group. ( 27847267 )
2017
11
Primary breast lymphoma: a case report. ( 28270358 )
2017
12
Primary breast lymphoma: A single center study. ( 28356993 )
2017
13
Primary Breast Lymphoma with cutaneous involvement in a patient with Rheumatoid Arthritis - a complication of infliximab therapy? ( 28375194 )
2017
14
Primary Breast Lymphoma-Population-Level Insights into an Infrequent but Increasingly Recognized Subtype of Lymphoma. ( 28376146 )
2017
15
Primary Breast Lymphoma in the United States: 1975-2013. ( 28376147 )
2017
16
Role of core needle biopsy in primary breast lymphoma. ( 28510806 )
2017
17
Diffuse Large B-Cell Breast Lymphoma: A Case Series. ( 28839450 )
2017
18
Primary Breast Lymphoma: A Case Report and Review of the Literature. ( 28839526 )
2017
19
Breast lymphoma in a patient with B-cell Non Hodgkin Lymphoma: A case report study. ( 28915427 )
2017
20
Sonoelastography of Breast Lymphoma. ( 26808169 )
2016
21
Primary Breast Lymphoma in a Woman: A Case Report and Review of the Literature. ( 26893404 )
2016
22
Radiation therapy for primary breast lymphoma in male gynecomastia: a rare case report and review of the literature. ( 27225235 )
2016
23
Breast Lymphoma Treatment Outcomes in a Pakistani Population: 20 Years of Experience at a Single Center. ( 27510022 )
2016
24
First pathological study of canine primary breast lymphoma and the description of its clinicopathological characteristics as an animal model for human primary breast lymphoma. ( 25469251 )
2015
25
Clinicopathological features of thirty patients with primary breast lymphoma and review of the literature. ( 25572809 )
2015
26
F-18 FDG PET/MRI findings of primary breast lymphoma in two cases: FDG PET/MRI findings of primary breast lymphoma. ( 25748090 )
2015
27
Report of a case of primary breast lymphoma highlighting the importance of fine needle aspiration cytology as an initial diagnostic tool. ( 26229252 )
2015
28
MRI features of breast lymphoma: preliminary experience in seven cases. ( 26380896 )
2015
29
Primary breast lymphoma presenting as non-healing axillary abscess. ( 26446318 )
2015
30
Primary breast lymphoma with progression to the scalp. ( 26458702 )
2015
31
Primary breast lymphoma: 30 years of experience with diagnosis and treatment at a single medical center. ( 24257833 )
2014
32
Breast lymphoma combined with postoperative acute hematopoietic disorder in an immediate breast reconstruction patient. ( 24491455 )
2014
33
Isolated cerebellar hypermetabolism on FDG PET in a case of remitted primary breast lymphoma. ( 24591788 )
2014
34
Primary breast lymphoma. ( 24953564 )
2014
35
Synchronous breast cancer and breast lymphoma: two case reports and literature review. ( 25035665 )
2014
36
Primary breast lymphoma: a single-institute experience in Taiwan. ( 25179707 )
2014
37
Primary diffuse large B-cell lymphoma of the nipple: a rare case of breast lymphoma localized in the nipple. ( 23316783 )
2013
38
Primary breast lymphoma: a single institution's experience. ( 23646311 )
2013
39
Unusual breast neoplasm: primary breast lymphoma. ( 23749857 )
2013
40
Breast lymphoma presenting as gynecomastia in male patient. ( 23815269 )
2013
41
MR imaging of malignant primary breast lymphoma: including diffusion-weighted imaging, histologic features, and a literature review. ( 23846235 )
2013
42
Three Cases of Combined Therapy in Primary Breast Lymphoma (PBL) with Successful Outcomes. ( 23885182 )
2013
43
Primary breast lymphoma. ( 23906238 )
2013
44
Bilateral primary breast lymphoma in a teenage girl with multi-organ involvement. ( 24026996 )
2013
45
The features of breast lymphoma on MRI. ( 24029630 )
2013
46
Cytodiagnosis of the primary breast lymphoma in a young woman. ( 24648678 )
2013
47
Primary breast lymphoma in males-a report of two cases with a review of the literature. ( 24723970 )
2013
48
Primary breast lymphoma sequentially relapsed in the peripheral and central nervous system. ( 22426680 )
2012
49
Synchronous bilateral primary breast lymphoma. ( 22616682 )
2012
50
Primary and secondary breast lymphoma: prevalence, clinical signs and radiological features. ( 22665932 )
2012

Variations for Breast Lymphoma

Expression for Breast Lymphoma

Search GEO for disease gene expression data for Breast Lymphoma.

Pathways for Breast Lymphoma

Pathways related to Breast Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.2 CD5 CD79A MME
2 11.14 CD5 MME
3 10.52 BCL6 CD5 MME

GO Terms for Breast Lymphoma

Biological processes related to Breast Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.13 BCL6 CD79A PIBF1
2 B cell differentiation GO:0030183 8.62 BCL6 CD79A

Molecular functions related to Breast Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 8.62 CD5 CD79A

Sources for Breast Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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