MCID: BRS007
MIFTS: 34

Breast Malignant Phyllodes Tumor

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Breast Malignant Phyllodes Tumor

MalaCards integrated aliases for Breast Malignant Phyllodes Tumor:

Name: Breast Malignant Phyllodes Tumor 12 15
Malignant Phyllodes Tumor of Breast 12 73
Malignant Cystosarcoma Phyllodes 12 73
Phyllodes Tumor of the Breast 53 59
Phyllodes Breast Tumor 12 53
Cystosarcoma Phyllodes of the Breast 59
Malignant Mammary Phyllodes Tumor 12
Malignant Phyllodes Neoplasm 12
Phyllodes Tumor, Malignant 12
Malignant Phyllodes Tumor 12
Phyllodes Breast Neoplasm 12
Cystosarcoma Phyllodes 53
Breast Phyllodes Tumor 73
Phylloides Tumor 53
Phyllodes Tumor 73

Characteristics:

Orphanet epidemiological data:

59
phyllodes tumor of the breast
Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:3016
MeSH 44 D003557
SNOMED-CT 68 87913009
Orphanet 59 ORPHA180261
ICD10 via Orphanet 34 D48.6
MESH via Orphanet 45 D003557
UMLS via Orphanet 74 C0010701

Summaries for Breast Malignant Phyllodes Tumor

NIH Rare Diseases : 53 Phyllodes tumors of the breast are rare tumors that start in the connective (stromal) tissue of the breast. They get their name from the leaf-like pattern in which they grow (phyllodes means leaf-like in Greek). They are most common in women in their 30s and 40s, although women of any age can be affected. These tumors, which are usually painless, tend to grow quickly, but rarely spread outside of the breast. Most phyllodes tumors are benign. About 1 in 10 are cancerous. The underlying cause of these tumors in unknown. Surgery is the main treatment. Because the tumors can reoccur if they are not removed with enough surrounding tissue, the tumor and at least 1 cm of tissue should be removed. Cancerous phyllodes tumors are often treated with mastectomy. Close follow-up with frequent breast examinations are recommended after surgery.   

MalaCards based summary : Breast Malignant Phyllodes Tumor, also known as malignant phyllodes tumor of breast, is related to benign prostate phyllodes tumor and prostate malignant phyllodes tumor. An important gene associated with Breast Malignant Phyllodes Tumor is PTS (6-Pyruvoyltetrahydropterin Synthase), and among its related pathways/superpathways is TP53 Regulates Metabolic Genes. Affiliated tissues include breast, lung and ovary, and related phenotypes are cardiovascular system and homeostasis/metabolism

Disease Ontology : 12 A breast cancer that is characterized by a prominent infiltrative border, unequivocal sarcomatous areas, and stromal overgrowth and arises_from the stroma, lined by an epithelial and myoepithelial bilayer, forming a leaflike structure. They tend to grow rapidly and present in middle-aged women (40s-50s).

Related Diseases for Breast Malignant Phyllodes Tumor

Diseases in the Benign Breast Phyllodes Tumor family:

Breast Malignant Phyllodes Tumor

Diseases related to Breast Malignant Phyllodes Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 benign prostate phyllodes tumor 11.4
2 prostate malignant phyllodes tumor 11.3
3 li-fraumeni syndrome 11.3
4 li-fraumeni syndrome 2 11.3
5 breast fibroadenoma 10.6
6 sarcoma 10.5
7 osteogenic sarcoma 10.4
8 infant gynecomastia 10.3
9 gynecomastia 10.3
10 adenocarcinoma 10.3
11 liposarcoma 10.3
12 benign breast phyllodes tumor 10.2
13 angiosarcoma 10.2
14 ovarian brenner tumor 10.2
15 scirrhous adenocarcinoma 10.2
16 breast giant fibroadenoma 10.2
17 desmoid tumor 10.2
18 soft tissue sarcoma 10.2
19 fibromatosis 10.1
20 infantile digital fibromatosis 10.1
21 retroperitoneal leiomyosarcoma 10.1 PGR PTS
22 well-differentiated liposarcoma 10.1
23 endometrium carcinoma in situ 10.1 PGR TP53
24 olfactory groove meningioma 10.1 PGR TP53
25 leiomyosarcoma 10.1 PGR TP53
26 synchronous bilateral breast carcinoma 10.1 PGR TP53
27 papillary serous adenocarcinoma 10.1 PGR TP53
28 uterine body mixed cancer 10.1 PGR TP53
29 bartholin's gland disease 10.1 PGR TP53
30 female reproductive endometrioid cancer 10.1 PGR TP53
31 cervical carcinosarcoma 10.1 PGR TP53
32 carcinosarcoma 10.1 PGR TP53
33 glycogen-rich clear cell breast carcinoma 10.1 PGR TP53
34 microglandular adenosis 10.1 PGR TP53
35 anterior cranial fossa meningioma 10.1 PGR TP53
36 adenosarcoma 10.0 PGR TP53
37 uterine corpus cancer 10.0 PGR TP53
38 mammary paget's disease 10.0
39 mixed cell type cancer 10.0 PGR TP53
40 primary peritoneal carcinoma 10.0 PGR TP53
41 pre-malignant neoplasm 10.0 PGR TP53
42 fallopian tube carcinoma 10.0 PGR TP53
43 papillary adenocarcinoma 10.0 PGR TP53
44 in situ carcinoma 10.0 PGR TP53
45 muscle cancer 10.0 PGR TP53
46 breast carcinoma in situ 10.0 PGR TP53
47 malignant ovarian surface epithelial-stromal neoplasm 10.0 PGR TP53
48 ovary epithelial cancer 10.0 PGR TP53
49 female breast cancer 10.0 PGR TP53
50 serous cystadenocarcinoma 10.0 PGR TP53

Graphical network of the top 20 diseases related to Breast Malignant Phyllodes Tumor:



Diseases related to Breast Malignant Phyllodes Tumor

Symptoms & Phenotypes for Breast Malignant Phyllodes Tumor

MGI Mouse Phenotypes related to Breast Malignant Phyllodes Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 AGO2 HSD11B2 NEK8 PGR PTS TP53
2 homeostasis/metabolism MP:0005376 9.63 AGO2 HSD11B2 NEK8 PGR PTS TP53
3 mortality/aging MP:0010768 9.43 AGO2 HSD11B2 NEK8 PGR PTS TP53
4 muscle MP:0005369 8.92 HSD11B2 PGR PTS TP53

Drugs & Therapeutics for Breast Malignant Phyllodes Tumor

Search Clinical Trials , NIH Clinical Center for Breast Malignant Phyllodes Tumor

Genetic Tests for Breast Malignant Phyllodes Tumor

Anatomical Context for Breast Malignant Phyllodes Tumor

MalaCards organs/tissues related to Breast Malignant Phyllodes Tumor:

41
Breast, Lung, Ovary, Prostate

Publications for Breast Malignant Phyllodes Tumor

Articles related to Breast Malignant Phyllodes Tumor:

# Title Authors Year
1
Pleomorphic liposarcoma arising in a malignant phyllodes tumor of breast: A rare occurrence. ( 26881623 )
2015
2
Synchronous bilateral primary breast malignant phyllodes tumor and carcinoma of the breast with Paget's disease: a case report and review of the literature. ( 26770378 )
2015
3
Angiosarcoma in recurrent malignant phyllodes tumor of breast. ( 22771666 )
2012
4
Invasive cribriform carcinoma arising in malignant phyllodes tumor of breast: a case report. ( 23110003 )
2012
5
Major response to sunitinib (Sutene) in metastatic malignant phyllodes tumor of breast. ( 19002383 )
2009
6
Malignant phyllodes tumor of breast with lung metastases mimicking the primary. ( 9777991 )
1998

Variations for Breast Malignant Phyllodes Tumor

Expression for Breast Malignant Phyllodes Tumor

Search GEO for disease gene expression data for Breast Malignant Phyllodes Tumor.

Pathways for Breast Malignant Phyllodes Tumor

Pathways related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.55 AGO2 TP53

GO Terms for Breast Malignant Phyllodes Tumor

Cellular components related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.17 AGO2 HSD11B2 NEK8 NT5C1B PGR PTS

Molecular functions related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 8.62 HSD11B2 PGR

Sources for Breast Malignant Phyllodes Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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