MCID: BRS007
MIFTS: 39

Breast Malignant Phyllodes Tumor

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Breast Malignant Phyllodes Tumor

MalaCards integrated aliases for Breast Malignant Phyllodes Tumor:

Name: Breast Malignant Phyllodes Tumor 12 15
Cystosarcoma Phyllodes of the Breast 54 60
Malignant Phyllodes Tumor of Breast 12 74
Malignant Cystosarcoma Phyllodes 12 74
Phyllodes Tumor of the Breast 54 60
Phyllodes Breast Tumor 12 54
Malignant Mammary Phyllodes Tumor 12
Malignant Breast Phyllodes Tumor 17
Malignant Phyllodes Neoplasm 12
Phyllodes Tumor, Malignant 12
Malignant Phyllodes Tumor 12
Phyllodes Breast Neoplasm 12
Cystosarcoma Phyllodes 54
Breast Phyllodes Tumor 74
Phylloides Tumor 54
Phyllodes Tumor 74

Characteristics:

Orphanet epidemiological data:

60
phyllodes tumor of the breast
Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:3016
MeSH 45 D003557
SNOMED-CT 69 87913009
MESH via Orphanet 46 D003557
ICD10 via Orphanet 35 D48.6
UMLS via Orphanet 75 C0010701
Orphanet 60 ORPHA180261

Summaries for Breast Malignant Phyllodes Tumor

NIH Rare Diseases : 54 Phyllodes tumors of the breast are rare tumors that start in the connective (stromal) tissue of the breast. They get their name from the leaf-like pattern in which they grow (phyllodes means leaf-like in Greek). They are most common in women in their 30s and 40s, although women of any age can be affected. These tumors, which are usually painless, tend to grow quickly, but rarely spread outside of the breast. Most phyllodes tumors are benign. About 1 in 10 are cancerous. The underlying cause of these tumors in unknown. Surgery is the main treatment. Because the tumors can reoccur if they are not removed with enough surrounding tissue, the tumor and at least 1 cm of tissue should be removed. Cancerous phyllodes tumors are often treated with mastectomy. Close follow-up with frequent breast examinations are recommended after surgery.   

MalaCards based summary : Breast Malignant Phyllodes Tumor, also known as cystosarcoma phyllodes of the breast, is related to benign prostate phyllodes tumor and prostate malignant phyllodes tumor. An important gene associated with Breast Malignant Phyllodes Tumor is PTS (6-Pyruvoyltetrahydropterin Synthase), and among its related pathways/superpathways is TP53 Regulates Metabolic Genes. The drugs Lidocaine and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

Disease Ontology : 12 A breast cancer that is characterized by a prominent infiltrative border, unequivocal sarcomatous areas, and stromal overgrowth and arises_from the stroma, lined by an epithelial and myoepithelial bilayer, forming a leaflike structure. They tend to grow rapidly and present in middle-aged women (40s-50s).

Related Diseases for Breast Malignant Phyllodes Tumor

Diseases in the Benign Breast Phyllodes Tumor family:

Breast Malignant Phyllodes Tumor

Diseases related to Breast Malignant Phyllodes Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 benign prostate phyllodes tumor 11.4
2 prostate malignant phyllodes tumor 11.3
3 li-fraumeni syndrome 11.3
4 li-fraumeni syndrome 2 11.3
5 breast fibroadenoma 10.6
6 benign breast phyllodes tumor 10.6
7 sarcoma 10.5
8 osteogenic sarcoma 10.4
9 infant gynecomastia 10.3
10 gynecomastia 10.3
11 adenocarcinoma 10.3
12 liposarcoma 10.3
13 breast cancer 10.3
14 celiac disease 1 10.2
15 chondrosarcoma 10.2
16 angiosarcoma 10.2
17 desmoid tumor 10.2
18 malignant fibroxanthoma 10.2
19 fibrosarcoma 10.2
20 scirrhous adenocarcinoma 10.2
21 histiocytoma 10.2
22 fibrous histiocytoma 10.2
23 paraplegia 10.2
24 breast giant fibroadenoma 10.2
25 soft tissue sarcoma 10.2
26 undifferentiated pleomorphic sarcoma 10.2
27 fibromatosis 10.1
28 infantile digital fibromatosis 10.1
29 mixed glioma 10.1 AGO2 TP53
30 breast liposarcoma 10.1
31 hypoglycemia 10.1
32 well-differentiated liposarcoma 10.1
33 mammary paget's disease 10.1
34 adenoma 10.1
35 retroperitoneal leiomyosarcoma 10.0 PGR PTS
36 neurilemmoma 10.0
37 cardiogenic shock 10.0
38 ocular motor apraxia 10.0
39 islet cell tumor 10.0
40 hypoglycemic coma 10.0
41 melanoma 10.0
42 breast disease 10.0
43 endometrium carcinoma in situ 10.0 PGR TP53
44 intussusception 10.0
45 retinoblastoma 10.0
46 aneurysmal bone cysts 10.0
47 breast reconstruction 10.0
48 leukemia 10.0
49 megakaryocytic leukemia 10.0
50 cribriform carcinoma 10.0

Graphical network of the top 20 diseases related to Breast Malignant Phyllodes Tumor:



Diseases related to Breast Malignant Phyllodes Tumor

Symptoms & Phenotypes for Breast Malignant Phyllodes Tumor

MGI Mouse Phenotypes related to Breast Malignant Phyllodes Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 AGO2 HSD11B2 NEK8 PGR PTS TP53
2 homeostasis/metabolism MP:0005376 9.63 AGO2 HSD11B2 NEK8 PGR PTS TP53
3 mortality/aging MP:0010768 9.43 AGO2 HSD11B2 NEK8 PGR PTS TP53
4 muscle MP:0005369 8.92 HSD11B2 PGR PTS TP53

Drugs & Therapeutics for Breast Malignant Phyllodes Tumor

Drugs for Breast Malignant Phyllodes Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
2 Anesthetics Not Applicable
3 Peripheral Nervous System Agents Not Applicable
4 Calamus Not Applicable
5 Anti-Arrhythmia Agents Not Applicable
6 Central Nervous System Depressants Not Applicable
7 Anesthetics, Local Not Applicable
8 Diuretics, Potassium Sparing Not Applicable
9 Sodium Channel Blockers Not Applicable
10 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Establishing Technique for PECS2 Catheter Insertion Unknown status NCT03030677 Not Applicable Lidocaine
2 Radiation Therapy After Surgery in Treating Women With Phyllodes Tumor of the Breast Completed NCT00003404 Not Applicable
3 Comparing Vacuum-Assisted Percutaneous Excision to Open Surgical Excision for Borderline or High-Risk Breast Lesions Not yet recruiting NCT03868475 Not Applicable

Search NIH Clinical Center for Breast Malignant Phyllodes Tumor

Genetic Tests for Breast Malignant Phyllodes Tumor

Anatomical Context for Breast Malignant Phyllodes Tumor

MalaCards organs/tissues related to Breast Malignant Phyllodes Tumor:

42
Breast, Prostate, Kidney, Bone, Ovary

Publications for Breast Malignant Phyllodes Tumor

Articles related to Breast Malignant Phyllodes Tumor:

(show all 40)
# Title Authors Year
1
Pulmonary Metastasis of a Gigantic Cystosarcoma Phyllodes of the Breast. ( 29521304 )
2018
2
Breast malignant phyllodes tumor with rare pelvic metastases and long-term overall survival: A case report and literature review. ( 27661051 )
2016
3
Synchronous bilateral primary breast malignant phyllodes tumor and carcinoma of the breast with Paget's disease: a case report and review of the literature. ( 26770378 )
2015
4
A Rare Case of Breast Malignant Phyllodes Tumor With Metastases to the Kidney: Case Report. ( 26287414 )
2015
5
Staging resection and reconstruction with temporary wound VAC coverage in a case of giant cystosarcoma phyllodes of the breast. ( 25528032 )
2015
6
A pulmonary metastasis of a cystosarcoma phyllodes of the breast detected by 18F-FDG PET/CT. ( 23603592 )
2014
7
Cystosarcoma phyllodes of the breast: a case report in a 12-year-old girl. ( 20947486 )
2010
8
Temporary remission of a multirecurrent cystosarcoma phyllodes of the breast by using continuous chemotherapy. ( 19182582 )
2009
9
Cystosarcoma phyllodes of the breast: a rare diagnosis: case studies and review of literature. ( 17549503 )
2007
10
Malignant cystosarcoma phyllodes of the breast treated with oncoplastic conservative surgery. ( 15730464 )
2005
11
Residents' case series: Insulin-secreting cystosarcoma phyllodes of the breast: a case report and literature review. ( 15384469 )
2004
12
Perioperative diagnosis of cystosarcoma phyllodes of the breast may be enhanced by MIB-1 index. ( 15522319 )
2004
13
Cystosarcoma phyllodes of the breast occurring in a child with subsequent diagnosis of celiac disease. ( 12717090 )
2003
14
Cystosarcoma phyllodes of the breast: a clinicopathological study of 11 cases. ( 12926760 )
2003
15
Immunohistochemical profile of cystosarcoma phyllodes of the breast: a study of 23 cases. ( 12390361 )
2002
16
Primary treatment of cystosarcoma phyllodes of the breast. ( 11013364 )
2000
17
Bilateral cystosarcoma phyllodes of the breast: a case report of malignant form with contralateral benign form. ( 11149968 )
2000
18
Cystosarcoma phyllodes of the breast: prognostic significance of proliferation and apoptosis associated genes. ( 10652633 )
1999
19
Cystosarcoma phyllodes of the breast. ( 21590025 )
1997
20
Cystosarcoma phyllodes of the breast: histologic features, flow cytometric analysis, and clinical correlations. ( 1323101 )
1992
21
DNA content and proliferative activity of cystosarcoma phyllodes of the breast. Potential prognostic significance. ( 2157332 )
1990
22
Cystosarcoma phyllodes of the breast. ( 2173680 )
1990
23
Cystosarcoma phyllodes of the breast: a cytologic and clinicopathologic study of 23 cases. ( 2541987 )
1989
24
Phyllodes tumor (cystosarcoma phyllodes) of the breast. A clinicopathologic study of 45 cases. ( 2834912 )
1988
25
Malignant cystosarcoma phyllodes of the breast metastatic to the oral cavity: report of a case and review of the literature. ( 2849080 )
1988
26
An unusual case of malignant cystosarcoma phyllodes of the breast. ( 3009283 )
1986
27
Estrogen receptors in cystosarcoma phyllodes of the breast. ( 6279408 )
1981
28
Cystosarcoma phyllodes of the breast with features of malignant fibrous histiocytoma. ( 6244714 )
1980
29
Estradiol binding protein in cystosarcoma phyllodes of the breast. ( 6248344 )
1980
30
Tubular carcinoma developing within a recurring cystosarcoma phyllodes of the breast. ( 6253046 )
1980
31
[Cystosarcoma phyllodes of the breast. A review and clinical cases]. ( 199973 )
1977
32
Desmoid tumor associated with cystosarcoma phyllodes of the breast. ( 175220 )
1976
33
Cystosarcoma phyllodes of the breast. ( 184742 )
1976
34
Cystosarcoma phyllodes of the breast. ( 172513 )
1975
35
Cystosarcoma phyllodes of the breast. ( 4362487 )
1974
36
Cystosarcoma phyllodes of the breast. A statisical study of forty cases. ( 4302487 )
1968
37
MALIGNANT CYSTOSARCOMA PHYLLODES OF THE BREAST IN ADOLESCENCE, WITH SUBSEQUENT PREGNANCY: REPORT OF A CASE WITH ENDOCRINOLOGIC STUDIES. ( 14110049 )
1964
38
Cystosarcoma phyllodes of the breast. ( 13903555 )
1962
39
Cystosarcoma phyllodes of the breast; a review of the literature with the addition of 15 new cases. ( 12986665 )
1952
40
Cystosarcoma phyllodes of the breast: a malignant and a benign tumor; a clinicopathological study of seventy-seven cases. ( 14886887 )
1951

Variations for Breast Malignant Phyllodes Tumor

Expression for Breast Malignant Phyllodes Tumor

Search GEO for disease gene expression data for Breast Malignant Phyllodes Tumor.

Pathways for Breast Malignant Phyllodes Tumor

Pathways related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.55 AGO2 TP53

GO Terms for Breast Malignant Phyllodes Tumor

Cellular components related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.17 AGO2 HSD11B2 NEK8 NT5C1B PGR PTS

Molecular functions related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 8.62 HSD11B2 PGR

Sources for Breast Malignant Phyllodes Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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