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MCID: BRS007
MIFTS: 39

Breast Malignant Phyllodes Tumor

Categories: Cancer diseases, Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Breast Malignant Phyllodes Tumor

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MalaCards integrated aliases for Breast Malignant Phyllodes Tumor:

Name: Breast Malignant Phyllodes Tumor 12 15
Cystosarcoma Phyllodes of the Breast 53 59
Malignant Phyllodes Tumor of Breast 12 72
Malignant Cystosarcoma Phyllodes 12 72
Phyllodes Tumor of the Breast 53 59
Phyllodes Breast Tumor 12 53
Malignant Mammary Phyllodes Tumor 12
Malignant Breast Phyllodes Tumor 17
Malignant Phyllodes Neoplasm 12
Phyllodes Tumor, Malignant 12
Malignant Phyllodes Tumor 12
Phyllodes Breast Neoplasm 12
Cystosarcoma Phyllodes 53
Breast Phyllodes Tumor 72
Phylloides Tumor 53
Phyllodes Tumor 72

Characteristics:

Orphanet epidemiological data:

59
phyllodes tumor of the breast
Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 59  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:3016
MeSH 44 D003557
SNOMED-CT 68 87913009
MESH via Orphanet 45 D003557
ICD10 via Orphanet 34 D48.6
UMLS via Orphanet 73 C0010701
Orphanet 59 ORPHA180261
UMLS 72 C0010701 C0238031 C0346154 more
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Summaries for Breast Malignant Phyllodes Tumor

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NIH Rare Diseases : 53 Phyllodes tumors of the breast are rare tumors that start in the connective (stromal) tissue of the breast. They get their name from the leaf-like pattern in which they grow (phyllodes means leaf-like in Greek). They are most common in women in their 30s and 40s, although women of any age can be affected. These tumors, which are usually painless, tend to grow quickly, but rarely spread outside of the breast. Most phyllodes tumors are benign. About 1 in 10 are cancerous. The underlying cause of these tumors in unknown. Surgery is the main treatment. Because the tumors can reoccur if they are not removed with enough surrounding tissue, the tumor and at least 1 cm of tissue should be removed. Cancerous phyllodes tumors are often treated with mastectomy. Close follow-up with frequent breast examinations are recommended after surgery.

MalaCards based summary : Breast Malignant Phyllodes Tumor, also known as cystosarcoma phyllodes of the breast, is related to breast fibroadenoma and benign breast phyllodes tumor. An important gene associated with Breast Malignant Phyllodes Tumor is MED12 (Mediator Complex Subunit 12), and among its related pathways/superpathways is Central carbon metabolism in cancer. The drugs Parathyroid hormone and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include breast, pancreas and liver, and related phenotypes are Decreased BBC3 mRNA expression and Decreased CDKN1A mRNA expression

Disease Ontology : 12 A breast cancer that is characterized by a prominent infiltrative border, unequivocal sarcomatous areas, and stromal overgrowth and arises from the stroma, lined by an epithelial and myoepithelial bilayer, forming a leaflike structure. They tend to grow rapidly and present in middle-aged women (40s-50s).

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Related Diseases for Breast Malignant Phyllodes Tumor

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Diseases in the Benign Breast Phyllodes Tumor family:

Breast Malignant Phyllodes Tumor

Diseases related to Breast Malignant Phyllodes Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 186)
# Related Disease Score Top Affiliating Genes
1 breast fibroadenoma 31.8 PGR MED12
2 benign breast phyllodes tumor 31.3 PGR KIT
3 in situ carcinoma 30.9 TP53 PGR
4 histiocytoma 30.7 TP53 KIT
5 female breast cancer 30.6 TP53 PGR
6 microglandular adenosis 30.5 TP53 PGR
7 embryonal sarcoma 30.4 TP53 KIT
8 ductal carcinoma in situ 30.4 TP53 PGR
9 malignant mesenchymoma 30.4 TP53 KIT
10 leiomyoma 30.3 PGR MED12 KIT
11 cribriform carcinoma 30.3 PGR KIT
12 adenosarcoma 30.1 TP53 PGR KIT
13 carcinosarcoma 30.1 TP53 PGR KIT
14 leiomyosarcoma 29.8 TP53 PGR MED12 KIT
15 benign prostate phyllodes tumor 11.5
16 li-fraumeni syndrome 11.4
17 li-fraumeni syndrome 2 11.4
18 rare tumor 10.7
19 breast cancer 10.6
20 sarcoma 10.6
21 spindle cell sarcoma 10.6
22 liposarcoma 10.5
23 rare breast tumor 10.5
24 fibrosarcoma 10.5
25 adenoma 10.5
26 osteogenic sarcoma 10.4
27 infant gynecomastia 10.4
28 gynecomastia 10.4
29 adenocarcinoma 10.4
30 leiomyomatosis 10.4 PGR MED12
31 myoma 10.4 PGR MED12
32 bizarre leiomyoma 10.4 PGR MED12
33 endometrium carcinoma in situ 10.4 TP53 PGR
34 olfactory groove meningioma 10.3 TP53 PGR
35 synchronous bilateral breast carcinoma 10.3 TP53 PGR
36 bartholin's gland disease 10.3 TP53 PGR
37 uterine body mixed cancer 10.3 TP53 PGR
38 spindle cell carcinoma 10.3
39 chondrosarcoma 10.3
40 malignant fibroxanthoma 10.3
41 constipation 10.3
42 fibrous histiocytoma 10.3
43 tubular adenocarcinoma 10.3
44 48,xyyy 10.3
45 soft tissue sarcoma 10.3
46 undifferentiated pleomorphic sarcoma 10.3
47 papillary serous adenocarcinoma 10.3 TP53 PGR
48 sarcomatoid renal cell carcinoma 10.3 TP53 KIT
49 cervical carcinosarcoma 10.3 TP53 PGR
50 female reproductive endometrioid cancer 10.3 TP53 PGR

Graphical network of the top 20 diseases related to Breast Malignant Phyllodes Tumor:



Diseases related to Breast Malignant Phyllodes Tumor
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Symptoms & Phenotypes for Breast Malignant Phyllodes Tumor

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GenomeRNAi Phenotypes related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased BBC3 mRNA expression GR00389-S-3 8.96 KMT2D TP53
2 Decreased CDKN1A mRNA expression GR00389-S-1 8.8 KMT2D TP53
3 Decreased CDKN1A mRNA expression GR00389-S-2 8.8 TP53

MGI Mouse Phenotypes related to Breast Malignant Phyllodes Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.88 HOXB13 KIT KMT2D NEK8 PGR TP53
2 cardiovascular system MP:0005385 9.85 KIT KMT2D MED12 NEK8 PGR TP53
3 cellular MP:0005384 9.8 HOXB13 KIT KMT2D MED12 PGR TP53
4 embryo MP:0005380 9.73 HOXB13 KIT KMT2D MED12 PGR TP53
5 limbs/digits/tail MP:0005371 9.55 HOXB13 KIT MED12 PGR TP53
6 neoplasm MP:0002006 9.26 KIT KMT2D PGR TP53
7 skeleton MP:0005390 9.1 HOXB13 KIT KMT2D MED12 PGR TP53
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Drugs & Therapeutics for Breast Malignant Phyllodes Tumor

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Drugs for Breast Malignant Phyllodes Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
2
Fluorouracil Approved Phase 1 51-21-8 3385
3
Belinostat Approved, Investigational Phase 1 866323-14-0
4 Androgens Phase 1
5 Immunologic Factors Phase 1
6 Histone Deacetylase Inhibitors Phase 1
7 Immunosuppressive Agents Phase 1
8 Antimetabolites Phase 1
9 Antimetabolites, Antineoplastic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I Safety, Pharmacodynamic, Anti-Tumor Activity, and Pharmacokinetic Study of PXD101 Alone and in Combination With 5-Fluorouracil in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)
2 A Prospective Study of Adjuvant Radiation Therapy After Resection of Borderline and Malignant Phyllodes Tumors Completed NCT00003404
3 A Prospective Study of Partial Breast Adjuvant Radiation Therapy After Resection of Borderline and Malignant Phyllodes Tumors Recruiting NCT01089374

Search NIH Clinical Center for Breast Malignant Phyllodes Tumor

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Genetic Tests for Breast Malignant Phyllodes Tumor

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Anatomical Context for Breast Malignant Phyllodes Tumor

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MalaCards organs/tissues related to Breast Malignant Phyllodes Tumor:

41
Breast, Pancreas, Liver, Lung, Skin, Kidney, Lymph Node
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Publications for Breast Malignant Phyllodes Tumor

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Articles related to Breast Malignant Phyllodes Tumor:

(show top 50) (show all 211)
# Title Authors PMID Year
1
Transcatheter arterial chemoembolization improves the resectability of malignant breast phyllodes tumor with angiosarcoma component: a case report. 38
31351458 2019
2
Cytologic diagnosis of metastatic malignant phyllodes tumor of the breast in pleural effusion. 38
30829462 2019
3
A rare case of a malignant phyllodes tumor of the breast associated with secretion of beta-human chorionic gonadotropin. 38
31192485 2019
4
Malignant phyllodes tumor of the breast with liposarcomatous differentiation: A case report with imaging findings. 38
30834064 2019
5
Phyllodes tumors of the breast. The treatment results for 340 patients from a single cancer centre. 38
30521986 2019
6
Recurrent borderline phyllodes tumor of the breast submitted to mastectomy and immediate reconstruction: Case report. 38
31195364 2019
7
Phyllodes tumor of the breast with nipple discharge: A case report. 38
30593154 2018
8
Percutaneous removal of benign phyllodes tumor of the breast: An alternative to surgery. 38
30251456 2018
9
Radiopathological characteristics and outcomes of phyllodes tumor of the breast in Malaysian women. 38
30075507 2018
10
Metastatic giant malignant phyllodes tumor of the breast. 38
29139587 2018
11
Phyllodes Tumor of the Breast: Ultrasound-Pathology Correlation. 38
29412020 2018
12
Early stage malignant phyllodes tumor case report. 38
29247967 2018
13
Malignant Phyllodes Tumor of the Breast with Metastasis to the Pancreas: A Case Report and Review of Literature. 38
30050709 2018
14
Phyllodes tumor masquerading as a fungating breast mass. 38
29250309 2017
15
Recurrent malignant phyllodes tumor of the breast: A case report. 38
29245318 2017
16
A rare presentation of malignant phyllodes tumor with bloody nipple discharge-report of a case. 38
28861384 2017
17
Radiation therapy for malignant phyllodes tumor of the breast: An analysis of SEER data. 38
28013032 2017
18
Giant phyllodes tumor of the breast with diffuse myxoid changes in an adolescent girl: a case report. 38
28458828 2017
19
Multiple metastatic malignant phyllodes tumor of the breast with tonsillar metastasis: a case report. 38
28103951 2017
20
A giant phyllodes tumor of the breast causing severe disfigurement. A case report. 38
28406095 2017
21
Clinicopathology and treatment of a giant malignant phyllodes tumor of the breast: A case report and literature review. 38
29121581 2017
22
Phyllodes Tumor of the Breast: Analysis of 48 Patients. 38
28331755 2016
23
A Giant Phyllodes Tumor of the Breast. 38
27746880 2016
24
A Case of Giant Borderline Phyllodes Tumor of the Breast Associated with Hypoglycemia. 38
27628602 2016
25
Insulin-like growth factor II messenger RNA-binding protein-3 is an indicator of malignant phyllodes tumor of the breast. 38
27137988 2016
26
Breast malignant phyllodes tumor with rare pelvic metastases and long-term overall survival: A case report and literature review. 38
27661051 2016
27
Giant malignant phyllodes tumor of the breast: A rare case report and literature review. 38
27347111 2016
28
Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates. 38
27362571 2016
29
Benign Phyllodes Tumor of the Breast Diagnosed After Ultrasound-Guided Vacuum-Assisted Biopsy: Surgical Excision or Wait-and-Watch? 38
26577125 2016
30
Treatment of Patients with Distant Metastases from Phyllodes Tumor of the Breast. 38
26464157 2016
31
The largest and neglected giant phyllodes tumor of the breast-A case report and literature review. 38
27475116 2016
32
Coexistence of malignant phyllodes tumor and her2-positive locally advanced breast cancer in distinct breasts: A case report. 38
26773878 2016
33
"Ruptured" malignant phyllodes tumor of the breast: a case report. 38
26952179 2016
34
Phyllodes Tumor of the Breast: 307 Treated Cases, the Largest Mexican Experience at a Single Breast Disease Institution. 38
28855932 2016
35
Multiplatform molecular profiling identifies potentially targetable biomarkers in malignant phyllodes tumors of the breast. 38
26625196 2016
36
Metastatic Malignant Phyllodes Tumor of the Breast: An Aggressive Disease-Analysis of 7 Cases. 38
27065662 2015
37
[Pulmonary Metastasis from a Phyllodes Tumor of the Breast Developing Sixteen Years after Initial Surgery]. 38
26555915 2015
38
Malignant phyllodes tumor of the breast with isolated intracranial metastases: A report. 38
26588634 2015
39
Pleomorphic liposarcoma arising in a malignant phyllodes tumor of breast: A rare occurrence. 38
26881623 2015
40
Phyllodes tumor of the breast: a clinic-pathologic study of 77 cases in a Hispanic cohort. 38
26600624 2015
41
Phyllodes Tumor of the Breast With Malignant Melanoma Component: A Case Report. 38
26113664 2015
42
A Rare Case of Breast Malignant Phyllodes Tumor With Metastases to the Kidney: Case Report. 38
26287414 2015
43
Identification of clinically relevant alterations in phyllodes tumor of the breast by amplicon-based next-generation sequencing. 38
25900796 2015
44
Large Malignant Phyllodes Tumor of the Breast with Metastases to the Lungs. 38
26266007 2015
45
[MRI features of phyllodes tumor of the breast and the pathological study]. 38
25931218 2015
46
Benign phyllodes tumor of the breast recurring as a malignant phyllodes tumor and spindle cell metaplastic carcinoma. 38
25476122 2015
47
Malignant phyllodes tumor of the breast with liposarcomatous differentiation and intraductal hyperplasia. 38
25061020 2015
48
Phyllodes tumor of the breast metastasizing to the vulva. 38
25960902 2015
49
Phyllodes tumor: review of key imaging characteristics. 38
25792027 2015
50
How to approach phyllodes tumors of the breast? 38
26668526 2015
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Variations for Breast Malignant Phyllodes Tumor

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Expression for Breast Malignant Phyllodes Tumor

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Search GEO for disease gene expression data for Breast Malignant Phyllodes Tumor.
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Pathways for Breast Malignant Phyllodes Tumor

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Pathways related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Central carbon metabolism in cancer 37
10.46 TP53 KIT
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GO Terms for Breast Malignant Phyllodes Tumor

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Biological processes related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 stem cell population maintenance GO:0019827 8.62 MED12 KIT
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Sources for Breast Malignant Phyllodes Tumor

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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