MCID: BRS007
MIFTS: 45

Breast Malignant Phyllodes Tumor

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Breast Malignant Phyllodes Tumor

MalaCards integrated aliases for Breast Malignant Phyllodes Tumor:

Name: Breast Malignant Phyllodes Tumor 12 15
Cystosarcoma Phyllodes of the Breast 20 58
Malignant Phyllodes Tumor of Breast 12 71
Malignant Cystosarcoma Phyllodes 12 71
Phyllodes Tumor of the Breast 20 58
Phyllodes Breast Tumor 12 20
Malignant Phyllodes Tumour of Breast 12
Malignant Mammary Phyllodes Tumour 12
Breast Malignant Phyllodes Tumour 12
Malignant Mammary Phyllodes Tumor 12
Malignant Breast Phyllodes Tumor 17
Malignant Phyllodes Neoplasm 12
Malignant Phyllodes Tumour 12
Phyllodes Tumor, Malignant 12
Malignant Phyllodes Tumor 12
Phyllodes Breast Neoplasm 12
Phyllodes Breast Tumour 12
Cystosarcoma Phyllodes 20
Breast Phyllodes Tumor 71
Phylloides Tumor 20
Phyllodes Tumor 71

Characteristics:

Orphanet epidemiological data:

58
phyllodes tumor of the breast
Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:3016
MeSH 44 D003557
MESH via Orphanet 45 D003557
ICD10 via Orphanet 33 D48.6
UMLS via Orphanet 72 C0010701
Orphanet 58 ORPHA180261
UMLS 71 C0010701 C0238031 C0346154 more

Summaries for Breast Malignant Phyllodes Tumor

GARD : 20 Phyllodes tumors of the breast are rare tumors that start in the connective (stromal) tissue of the breast. They get their name from the leaf-like pattern in which they grow (phyllodes means leaf-like in Greek). They are most common in women in their 30s and 40s, although women of any age can be affected. These tumors, which are usually painless, tend to grow quickly, but rarely spread outside of the breast. Most phyllodes tumors are benign. About 1 in 10 are cancerous. The underlying cause of these tumors in unknown. Surgery is the main treatment. Because the tumors can reoccur if they are not removed with enough surrounding tissue, the tumor and at least 1 cm of tissue should be removed. Cancerous phyllodes tumors are often treated with mastectomy. Close follow-up with frequent breast examinations are recommended after surgery.

MalaCards based summary : Breast Malignant Phyllodes Tumor, also known as cystosarcoma phyllodes of the breast, is related to li-fraumeni syndrome and scirrhous adenocarcinoma. An important gene associated with Breast Malignant Phyllodes Tumor is MED12 (Mediator Complex Subunit 12), and among its related pathways/superpathways are Developmental Biology and MAPK signaling pathway. Affiliated tissues include breast, pancreas and lymph node, and related phenotypes are cellular and behavior/neurological

Disease Ontology : 12 A breast cancer that is characterized by a prominent infiltrative border, unequivocal sarcomatous areas, and stromal overgrowth and arises from the stroma, lined by an epithelial and myoepithelial bilayer, forming a leaflike structure. They tend to grow rapidly and present in middle-aged women (40s-50s).

Related Diseases for Breast Malignant Phyllodes Tumor

Diseases in the Benign Breast Phyllodes Tumor family:

Breast Malignant Phyllodes Tumor

Diseases related to Breast Malignant Phyllodes Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 554)
# Related Disease Score Top Affiliating Genes
1 li-fraumeni syndrome 31.2 TP53 ESR1 ERBB2 EGFR
2 scirrhous adenocarcinoma 30.6 PGR ERBB2
3 prostate sarcoma 30.6 PGR CD34
4 gynecomastia 30.5 PGR ESR1 ERBB2
5 spindle cell sarcoma 30.5 SERPINA3 KIT CD34
6 malignant mesenchymoma 30.4 SERPINA3 CD34
7 fibrous histiocytoma 30.3 SERPINA3 KIT CD34
8 soft tissue sarcoma 30.3 TP53 EGFR
9 malignant fibrous histiocytoma 30.3 TP53 SERPINA3 KIT
10 benign breast phyllodes tumor 30.3 PGR MME KIT CD34
11 breast fibroadenoma 30.2 TP53 SERPINA3 PGR MME MED12 ESR1
12 papillary carcinoma 30.1 PGR ESR1 ERBB2
13 well-differentiated liposarcoma 30.1 TP53 SERPINA3 KIT CD34
14 bilateral breast cancer 30.1 PGR ESR1 ERBB2
15 angiosarcoma 30.0 TP53 KIT CD34
16 embryonal sarcoma 30.0 TP53 SERPINA3 KIT
17 neurilemmoma 30.0 SERPINA3 KIT CD34
18 acute megakaryocytic leukemia 29.9 TP53 KIT CD34
19 hypertrophy of breast 29.9 TP53 PGR ESR1 ERBB2
20 female breast cancer 29.9 TP53 PGR ESR1 ERBB2
21 deficiency anemia 29.8 SERPINA3 MME KIT CD34
22 intraductal papilloma 29.8 PGR KRT5 ESR1 ERBB2
23 mammary paget's disease 29.6 PGR ESR1 ERBB2 EGFR
24 lobular neoplasia 29.6 TP53 PGR KRT5 ESR1 ERBB2
25 adenocarcinoma 29.5 TP53 KIT ERBB2 EGFR
26 prostatic hypertrophy 29.5 SERPINA3 PGR ESR1 EGFR
27 mesenchymal cell neoplasm 29.5 TP53 SERPINA3 MME KIT CD34
28 papilloma 29.5 TP53 KRT5 ERBB2 EGFR
29 leiomyosarcoma 29.4 TP53 SERPINA3 PGR MED12 KIT ESR1
30 inflammatory breast carcinoma 29.4 PGR ESR1 ERBB2 EGFR
31 tubular adenocarcinoma 29.4 PGR MME ESR1 ERBB2 EGFR
32 leiomyoma 29.3 PGR MME MED12 KIT ESR1 CD34
33 breast disease 29.3 TP53 SERPINA3 PGR KRT5 ESR1 ERBB2
34 cribriform carcinoma 29.3 PGR KRT5 KIT ESR1 ERBB2
35 breast sarcoma 29.3 TP53 PGR MME KRT5 ERBB2 CD34
36 breast adenocarcinoma 29.0 TP53 SERPINA3 PGR ESR1 ERBB2 EGFR
37 in situ carcinoma 28.9 TP53 SERPINA3 PGR KRT5 ESR1 ERBB2
38 adenosarcoma 28.8 TP53 SERPINA3 PGR MME KIT ESR1
39 carcinosarcoma 28.8 TP53 PGR MME KIT ERBB2 EGFR
40 microglandular adenosis 28.6 TP53 PGR KIT ESR1 ERBB2 EGFR
41 rhabdomyosarcoma 28.6 TP53 MME KIT ESR1 ERBB2 EGFR
42 ductal carcinoma in situ 28.5 TP53 PGR MME KRT5 ESR1 ERBB2
43 benign prostate phyllodes tumor 11.2
44 li-fraumeni syndrome 2 11.2
45 rare tumor 10.6
46 overgrowth syndrome 10.6
47 liposarcoma 10.4
48 rare breast tumor 10.4
49 fibromatosis 10.4
50 diffuse peritoneal leiomyomatosis 10.4 PGR MED12

Graphical network of the top 20 diseases related to Breast Malignant Phyllodes Tumor:



Diseases related to Breast Malignant Phyllodes Tumor

Symptoms & Phenotypes for Breast Malignant Phyllodes Tumor

MGI Mouse Phenotypes related to Breast Malignant Phyllodes Tumor:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.22 CD34 EGFR ERBB2 ESR1 KIT KMT2D
2 behavior/neurological MP:0005386 10.2 ERBB2 ESR1 KIT KMT2D KRT5 MME
3 cardiovascular system MP:0005385 10.19 EGFR ERBB2 ESR1 KIT KMT2D MED12
4 homeostasis/metabolism MP:0005376 10.16 CD34 EGFR ERBB2 ESR1 KIT KMT2D
5 integument MP:0010771 10.14 CD34 EGFR ERBB2 ESR1 KIT KMT2D
6 immune system MP:0005387 10.09 CD34 EGFR ESR1 KIT KMT2D KRT5
7 embryo MP:0005380 10.08 EGFR ERBB2 ESR1 KIT KMT2D MED12
8 craniofacial MP:0005382 10.05 EGFR ERBB2 KIT KMT2D KRT5 MED12
9 digestive/alimentary MP:0005381 9.97 EGFR ERBB2 ESR1 KIT KRT5 TP53
10 limbs/digits/tail MP:0005371 9.97 EGFR ERBB2 ESR1 KIT KRT5 MED12
11 muscle MP:0005369 9.87 EGFR ERBB2 ESR1 KIT KMT2D PGR
12 neoplasm MP:0002006 9.86 CD34 EGFR ERBB2 ESR1 KIT KMT2D
13 normal MP:0002873 9.7 EGFR ERBB2 ESR1 KIT MED12 PGR
14 respiratory system MP:0005388 9.43 EGFR ERBB2 ESR1 KIT KMT2D TP53
15 skeleton MP:0005390 9.23 EGFR ERBB2 ESR1 KIT KMT2D MED12

Drugs & Therapeutics for Breast Malignant Phyllodes Tumor

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective Study of Adjuvant Radiation Therapy After Resection of Borderline and Malignant Phyllodes Tumors Completed NCT00003404
2 A Prospective Study of Partial Breast Adjuvant Radiation Therapy After Resection of Borderline and Malignant Phyllodes Tumors Recruiting NCT01089374
3 Pilot Study on the Feasibility of Cryotherapy as an Alternative Treatment for Phyllodes Tumors/Breast Fibroepithelial Lesions (FELs) Needing Surgery Recruiting NCT04571307

Search NIH Clinical Center for Breast Malignant Phyllodes Tumor

Genetic Tests for Breast Malignant Phyllodes Tumor

Anatomical Context for Breast Malignant Phyllodes Tumor

MalaCards organs/tissues related to Breast Malignant Phyllodes Tumor:

40
Breast, Pancreas, Lymph Node, Kidney, Skin, Tonsil

Publications for Breast Malignant Phyllodes Tumor

Articles related to Breast Malignant Phyllodes Tumor:

(show top 50) (show all 242)
# Title Authors PMID Year
1
Outcomes of systemic therapy in metastatic phyllodes tumor of the breast. 61
33575859 2021
2
The role of adjuvant radiotherapy in patients with malignant phyllodes tumor of the breast: a propensity-score matching analysis. 61
32748225 2021
3
Pancreatic metastasis from malignant phyllodes tumor of the breast. 61
33242383 2021
4
Granulocyte-colony stimulating factor-producing malignant phyllodes tumor of the breast: a rare case. 61
33447858 2021
5
Malignant Phyllodes Tumor of the Breast With Metastasis to the Orbit: A Rare Case Report. 61
32732545 2021
6
Non-invasive ductal carcinoma within malignant phyllodes tumor of the breast. 61
33473040 2021
7
Phyllodes tumor of the breast clinical experience and outcomes: A retrospective cohort tertiary hospital experience. 61
33472142 2021
8
[Study of Phyllodes Tumor of the Breast in 44 Cases of Resection]. 61
33468770 2020
9
Giant malignant phyllodes tumor of the breast: Insights into optimal management and reconstructive options for a rare and challenging entity. 61
33108821 2020
10
Malignant phyllodes tumor of the breast with rapid progression: a case report. 61
33284362 2020
11
World's Oldest Case of Synchronous Bilateral Benign Phyllodes Tumors of the Breast: A Rare Occurrence. 61
33520491 2020
12
Early-onset malignant phyllodes breast tumor in a patient with germline pathogenic variants in NF1 and BRCA1 genes. 61
33210232 2020
13
Malignant phyllodes tumor with extensive lipomatous differentiation. 61
32994850 2020
14
En Bloc Excision of Phyllodes Tumor of the Breast: Radical Approach Heralds Better Outcome. 61
33046357 2020
15
Phyllodes Tumor of the Breast during Pregnancy and Lactation; A Systematic Review. 61
32657600 2020
16
Patterns of care and predictors of adjuvant radiation therapy in phyllodes tumor of the breast. 61
32275108 2020
17
ASO Author Reflections: How Far Should We Go in Local Management for a Localized Malignant Phyllodes Tumor of the Breast? 61
32206956 2020
18
Cutaneous Scalp Metastases of Malignant Phyllodes Tumor of the Breast. 61
32595994 2020
19
The Reconstruction after a Giant Phyllodes Tumor Resection Using a DIEP Flap. 61
32440428 2020
20
[Phyllodes tumor of the breast with heart and lung metastases: a case report]. 61
32146753 2020
21
Giant phyllodes tumor of the breast. 61
31486153 2020
22
Lacrimal Sac Metastasis from Phyllodes Tumor of the Breast. 61
32037753 2020
23
Comparison of mutation profile between primary phyllodes tumors of the breast and their paired local recurrences. 61
32429649 2020
24
Radiotherapy with apatinib for recurrence of malignant phyllodes tumor of the breast: A case report. 61
32011486 2020
25
Malignant Phyllodes Tumor of the Breast in a 26-year-old Woman. 61
32051802 2020
26
Pancreatic metastases and first reported gallbladder metastasis from phyllodes tumor of the breast. 61
33282161 2020
27
Phyllodes Tumor of the Breast in Pregnancy and Lactation. 61
32816274 2020
28
Immunohistochemical detection of paralogous 13 HOX genes in phyllodes tumor of the breast as a useful diagnostic tool. 61
33042341 2020
29
[Phyllodes Tumor of the Breast Occurring near Postoperative Fibroadenoma Scar-A Case Report]. 61
32381888 2020
30
Phyllodes Tumor of the Breast: A Clinicopathological Evaluation of 55 Cases. 61
31912011 2020
31
The response of phyllodes tumor of the breast to anticancer therapy: An in vitro and ex vivo study. 61
31612021 2019
32
A rare case of a malignant phyllodes tumor of the breast associated with secretion of beta-human chorionic gonadotropin. 61
31192485 2019
33
Transcatheter arterial chemoembolization improves the resectability of malignant breast phyllodes tumor with angiosarcoma component: a case report. 61
31351458 2019
34
Cytologic diagnosis of metastatic malignant phyllodes tumor of the breast in pleural effusion. 61
30829462 2019
35
Malignant phyllodes tumor of the breast with liposarcomatous differentiation: A case report with imaging findings. 61
30834064 2019
36
Phyllodes tumors of the breast. The treatment results for 340 patients from a single cancer centre. 61
30521986 2019
37
Phyllodes tumor of the breast: diagnosis, management and outcome during a 10-year experience. 61
31695485 2019
38
Not Every Fat-Containing Lesion on Mammogram is a Benign Finding: Case Report and Review of Breast Malignant Phyllodes Tumor with Heterologous Liposarcomatous Differentiation. 61
31448161 2019
39
Recurrent borderline phyllodes tumor of the breast submitted to mastectomy and immediate reconstruction: Case report. 61
31195364 2019
40
Phyllodes tumor of the breast with nipple discharge: A case report. 61
30593154 2018
41
Percutaneous removal of benign phyllodes tumor of the breast: An alternative to surgery. 61
30251456 2018
42
Radiopathological characteristics and outcomes of phyllodes tumor of the breast in Malaysian women. 61
30075507 2018
43
Metastatic giant malignant phyllodes tumor of the breast. 61
29139587 2018
44
Phyllodes Tumor of the Breast: Ultrasound-Pathology Correlation. 61
29412020 2018
45
Early stage malignant phyllodes tumor case report. 61
29247967 2018
46
Malignant Phyllodes Tumor of the Breast with Metastasis to the Pancreas: A Case Report and Review of Literature. 61
30050709 2018
47
Phyllodes tumor masquerading as a fungating breast mass. 61
29250309 2017
48
Recurrent malignant phyllodes tumor of the breast: A case report. 61
29245318 2017
49
A rare presentation of malignant phyllodes tumor with bloody nipple discharge-report of a case. 61
28861384 2017
50
Radiation therapy for malignant phyllodes tumor of the breast: An analysis of SEER data. 61
28013032 2017

Variations for Breast Malignant Phyllodes Tumor

Expression for Breast Malignant Phyllodes Tumor

Search GEO for disease gene expression data for Breast Malignant Phyllodes Tumor.

Pathways for Breast Malignant Phyllodes Tumor

Pathways related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.24 MED12 KRT5 KMT2D KIT ERBB2 EGFR
2 12.53 TP53 KIT ERBB2 EGFR
3 12.49 TP53 KIT ESR1 ERBB2 EGFR
4
Show member pathways
12.48 TP53 KIT ERBB2 EGFR
5
Show member pathways
12.43 TP53 ESR1 ERBB2 EGFR
6
Show member pathways
12.1 TP53 PGR KIT ESR1 ERBB2 EGFR
7 11.94 TP53 ESR1 EGFR
8 11.93 TP53 ESR1 ERBB2 EGFR
9 11.9 KIT ERBB2 EGFR
10
Show member pathways
11.78 TP53 ERBB2 EGFR
11 11.75 TP53 MED12 ESR1
12 11.72 MME KIT CD34
13 11.63 MME KIT CD34
14
Show member pathways
11.59 PGR ESR1 ERBB2 EGFR
15 11.48 MME KIT CD34
16 11.44 TP53 ERBB2 EGFR
17
Show member pathways
11.43 KIT ESR1 ERBB2 EGFR
18 10.77 TP53 KIT ERBB2 EGFR

GO Terms for Breast Malignant Phyllodes Tumor

Cellular components related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basal plasma membrane GO:0009925 8.8 ERBB2 EGFR CD34

Biological processes related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.88 TP53 PGR MED12 KMT2D ESR1 EGFR
2 peptidyl-tyrosine phosphorylation GO:0018108 9.74 KIT ERBB2 EGFR
3 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.73 KIT ERBB2 EGFR
4 negative regulation of gene expression GO:0010629 9.73 TP53 PGR ESR1 CD34
5 regulation of transcription by RNA polymerase II GO:0006357 9.7 TP53 PGR MED12 KIT ESR1 ERBB2
6 replicative senescence GO:0090399 9.55 TP53 MME
7 positive regulation of phospholipase C activity GO:0010863 9.54 KIT ESR1
8 positive regulation of kinase activity GO:0033674 9.54 KIT ERBB2 EGFR
9 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.52 TP53 EGFR
10 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.51 TP53 ESR1
11 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.49 TP53 ESR1
12 tongue development GO:0043586 9.48 KIT EGFR
13 intracellular steroid hormone receptor signaling pathway GO:0030518 9.46 PGR ESR1
14 paracrine signaling GO:0038001 9.32 PGR CD34
15 negative regulation of ERBB signaling pathway GO:1901185 9.26 ERBB2 EGFR
16 positive regulation of MAP kinase activity GO:0043406 9.13 KIT ERBB2 EGFR
17 positive regulation of protein kinase B signaling GO:0051897 8.92 KIT ESR1 ERBB2 EGFR

Molecular functions related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.73 TP53 MED12 ESR1 EGFR
2 enzyme binding GO:0019899 9.67 TP53 PGR ESR1 EGFR
3 transcription factor binding GO:0008134 9.62 TP53 MED12 ESR1 CD34
4 protein tyrosine kinase activity GO:0004713 9.58 KIT ERBB2 EGFR
5 protein phosphatase binding GO:0019903 9.43 TP53 ERBB2 EGFR
6 ATPase binding GO:0051117 9.33 PGR ESR1 EGFR
7 nitric-oxide synthase regulator activity GO:0030235 8.96 ESR1 EGFR
8 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 KIT ERBB2 EGFR

Sources for Breast Malignant Phyllodes Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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