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MCID: BRS007
MIFTS: 46

Breast Malignant Phyllodes Tumor

Categories: Cancer diseases, Rare diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Breast Malignant Phyllodes Tumor

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MalaCards integrated aliases for Breast Malignant Phyllodes Tumor:

Name: Breast Malignant Phyllodes Tumor 12 15
Cystosarcoma Phyllodes of the Breast 52 58
Malignant Phyllodes Tumor of Breast 12 71
Malignant Cystosarcoma Phyllodes 12 71
Phyllodes Tumor of the Breast 52 58
Phyllodes Breast Tumor 12 52
Malignant Phyllodes Tumour of Breast 12
Malignant Mammary Phyllodes Tumour 12
Breast Malignant Phyllodes Tumour 12
Malignant Mammary Phyllodes Tumor 12
Malignant Breast Phyllodes Tumor 17
Malignant Phyllodes Neoplasm 12
Malignant Phyllodes Tumour 12
Phyllodes Tumor, Malignant 12
Malignant Phyllodes Tumor 12
Phyllodes Breast Neoplasm 12
Phyllodes Breast Tumour 12
Cystosarcoma Phyllodes 52
Breast Phyllodes Tumor 71
Phylloides Tumor 52
Phyllodes Tumor 71

Characteristics:

Orphanet epidemiological data:

58
phyllodes tumor of the breast
Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

Disease Ontology 12 DOID:3016
MeSH 43 D003557
MESH via Orphanet 44 D003557
ICD10 via Orphanet 33 D48.6
UMLS via Orphanet 72 C0010701
Orphanet 58 ORPHA180261
UMLS 71 C0010701 C0238031 C0346154 more
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Summaries for Breast Malignant Phyllodes Tumor

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NIH Rare Diseases : 52 Phyllodes tumors of the breast are rare tumors that start in the connective (stromal) tissue of the breast. They get their name from the leaf-like pattern in which they grow (phyllodes means leaf-like in Greek). They are most common in women in their 30s and 40s, although women of any age can be affected. These tumors, which are usually painless, tend to grow quickly, but rarely spread outside of the breast. Most phyllodes tumors are benign. About 1 in 10 are cancerous. The underlying cause of these tumors in unknown. Surgery is the main treatment. Because the tumors can reoccur if they are not removed with enough surrounding tissue, the tumor and at least 1 cm of tissue should be removed. Cancerous phyllodes tumors are often treated with mastectomy. Close follow-up with frequent breast examinations are recommended after surgery.

MalaCards based summary : Breast Malignant Phyllodes Tumor, also known as cystosarcoma phyllodes of the breast, is related to li-fraumeni syndrome and scirrhous adenocarcinoma. An important gene associated with Breast Malignant Phyllodes Tumor is MED12 (Mediator Complex Subunit 12), and among its related pathways/superpathways are Pathways in cancer and Downstream signaling events of B Cell Receptor (BCR). The drugs Fluorouracil and Parathyroid hormone have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and pancreas, and related phenotypes are cellular and behavior/neurological

Disease Ontology : 12 A breast cancer that is characterized by a prominent infiltrative border, unequivocal sarcomatous areas, and stromal overgrowth and arises from the stroma, lined by an epithelial and myoepithelial bilayer, forming a leaflike structure. They tend to grow rapidly and present in middle-aged women (40s-50s).

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Related Diseases for Breast Malignant Phyllodes Tumor

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Diseases in the Benign Breast Phyllodes Tumor family:

Breast Malignant Phyllodes Tumor

Diseases related to Breast Malignant Phyllodes Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 515)
# Related Disease Score Top Affiliating Genes
1 li-fraumeni syndrome 31.2 TP53 ESR1 ERBB2 EGFR
2 scirrhous adenocarcinoma 30.9 PGR ERBB2
3 benign mesothelioma 30.7 KRT5 CD34
4 gynecomastia 30.7 PGR ESR1 ERBB2
5 benign breast phyllodes tumor 30.6 PGR MME MED12 KIT
6 malignant mesenchymoma 30.5 SERPINA3 CD34
7 soft tissue sarcoma 30.4 TP53 EGFR
8 malignant fibrous histiocytoma 30.4 TP53 SERPINA3 KIT
9 leiomyoma, uterine 30.4 PGR MED12 ESR1
10 spindle cell carcinoma 30.2 PGR KRT5 ESR1 CD34
11 angiosarcoma 30.1 TP53 KIT CD34
12 fibrous histiocytoma 30.1 TP53 SERPINA3 KIT CD34
13 papillary carcinoma 30.1 PGR ESR1 ERBB2
14 bilateral breast cancer 30.0 PGR ESR1 ERBB2
15 neurilemmoma 29.9 SERPINA3 KIT CD34
16 well-differentiated liposarcoma 29.9 TP53 SERPINA3 KIT CD34
17 embryonal sarcoma 29.9 TP53 SERPINA3 KIT
18 breast fibroadenoma 29.7 TP53 SERPINA3 PGR MME MED12 ESR1
19 intraductal papilloma 29.6 PGR KRT5 ESR1 ERBB2
20 lobular neoplasia 29.5 TP53 PGR KRT5 ESR1 ERBB2
21 mesenchymal cell neoplasm 29.4 TP53 SERPINA3 MME KIT CD34
22 mammary paget's disease 29.3 PGR ESR1 ERBB2 EGFR
23 leiomyosarcoma 29.3 TP53 SERPINA3 PGR MED12 KIT ESR1
24 prostatic hypertrophy 29.2 SERPINA3 PGR ESR1 EGFR
25 breast disease 29.2 TP53 SERPINA3 PGR KRT5 ESR1 ERBB2
26 tubular adenocarcinoma 29.2 PGR MME ESR1 ERBB2 EGFR
27 leiomyoma 29.1 PGR MME MED12 KIT ESR1 CD34
28 inflammatory breast carcinoma 29.1 PGR ESR1 ERBB2 EGFR
29 hypertrophy of breast 29.0 TP53 PGR ESR1 ERBB2 EGFR
30 female breast cancer 29.0 TP53 PGR ESR1 ERBB2 EGFR
31 papilloma 29.0 TP53 KRT5 ESR1 EGFR
32 cribriform carcinoma 28.9 PGR KRT5 KIT ESR1 ERBB2
33 gastrointestinal stromal tumor 28.8 TP53 KIT ERBB2 EGFR CD34
34 breast sarcoma 28.6 TP53 PGR MOCS2 MME KRT5 ERBB2
35 lymphoma 28.5 TP53 MME KMT2D KIT EGFR
36 in situ carcinoma 28.5 TP53 SERPINA3 PGR KRT5 ESR1 ERBB2
37 adenosarcoma 28.4 TP53 SERPINA3 PGR MME KIT ESR1
38 breast adenocarcinoma 28.4 TP53 SERPINA3 PGR MED12 ESR1 ERBB2
39 carcinosarcoma 28.4 TP53 PGR MME KIT ERBB2 EGFR
40 microglandular adenosis 28.1 TP53 PGR KIT ESR1 ERBB2 EGFR
41 ductal carcinoma in situ 28.1 TP53 PGR MME KRT5 ESR1 ERBB2
42 benign prostate phyllodes tumor 11.5
43 li-fraumeni syndrome 2 11.4
44 rare tumor 10.7
45 breast cancer 10.6
46 sarcoma 10.6
47 spindle cell sarcoma 10.6
48 liposarcoma 10.5
49 rare breast tumor 10.5
50 fibrosarcoma 10.5

Graphical network of the top 20 diseases related to Breast Malignant Phyllodes Tumor:



Diseases related to Breast Malignant Phyllodes Tumor
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Symptoms & Phenotypes for Breast Malignant Phyllodes Tumor

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MGI Mouse Phenotypes related to Breast Malignant Phyllodes Tumor:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.28 CD34 EGFR ERBB2 ESR1 KIT KMT2D
2 behavior/neurological MP:0005386 10.26 ERBB2 ESR1 KIT KMT2D KRT5 MME
3 homeostasis/metabolism MP:0005376 10.22 CD34 EGFR ERBB2 ESR1 KIT KMT2D
4 integument MP:0010771 10.2 CD34 EGFR ERBB2 ESR1 KIT KRT5
5 cardiovascular system MP:0005385 10.15 EGFR ERBB2 ESR1 KIT KMT2D MED12
6 embryo MP:0005380 10.1 EGFR ERBB2 ESR1 KIT KMT2D MED12
7 mortality/aging MP:0010768 10.1 EGFR ERBB2 ESR1 KIT KMT2D KRT5
8 craniofacial MP:0005382 10.07 EGFR ERBB2 KIT KMT2D KRT5 MED12
9 limbs/digits/tail MP:0005371 10.03 EGFR ERBB2 ESR1 KIT KRT5 MED12
10 digestive/alimentary MP:0005381 9.99 EGFR ERBB2 ESR1 KIT KRT5 TP53
11 muscle MP:0005369 9.97 EGFR ERBB2 ESR1 KIT KMT2D MOCS2
12 neoplasm MP:0002006 9.92 CD34 EGFR ERBB2 ESR1 KIT KMT2D
13 nervous system MP:0003631 9.91 EGFR ERBB2 ESR1 KIT KMT2D MED12
14 normal MP:0002873 9.7 EGFR ERBB2 ESR1 KIT MED12 PGR
15 respiratory system MP:0005388 9.43 EGFR ERBB2 ESR1 KIT KMT2D TP53
16 skeleton MP:0005390 9.23 EGFR ERBB2 ESR1 KIT KMT2D MED12
Sources

Drugs & Therapeutics for Breast Malignant Phyllodes Tumor

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Drugs for Breast Malignant Phyllodes Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 1 51-21-8 3385
2
Parathyroid hormone Approved, Investigational Phase 1 9002-64-6
3
Belinostat Approved, Investigational Phase 1 866323-14-0
4 Immunologic Factors Phase 1
5 Histone Deacetylase Inhibitors Phase 1
6 Androgens Phase 1
7 Immunosuppressive Agents Phase 1
8 Antimetabolites Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I Safety, Pharmacodynamic, Anti-Tumor Activity, and Pharmacokinetic Study of PXD101 Alone and in Combination With 5-Fluorouracil in Patients With Advanced Solid Tumors Completed NCT00413322 Phase 1 belinostat;5-Fluorouracil (5-FU)
2 A Prospective Study of Adjuvant Radiation Therapy After Resection of Borderline and Malignant Phyllodes Tumors Completed NCT00003404
3 A Prospective Study of Partial Breast Adjuvant Radiation Therapy After Resection of Borderline and Malignant Phyllodes Tumors Recruiting NCT01089374

Search NIH Clinical Center for Breast Malignant Phyllodes Tumor

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Genetic Tests for Breast Malignant Phyllodes Tumor

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Anatomical Context for Breast Malignant Phyllodes Tumor

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MalaCards organs/tissues related to Breast Malignant Phyllodes Tumor:

40
Breast, Lung, Pancreas, Lymph Node, Heart, Kidney, Liver
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Publications for Breast Malignant Phyllodes Tumor

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Articles related to Breast Malignant Phyllodes Tumor:

(show top 50) (show all 225)
# Title Authors PMID Year
1
ASO Author Reflections: How Far Should We Go in Local Management for a Localized Malignant Phyllodes Tumor of the Breast? 61
32206956 2020
2
The Reconstruction after a Giant Phyllodes Tumor Resection Using a DIEP Flap. 61
32440428 2020
3
Patterns of care and predictors of adjuvant radiation therapy in phyllodes tumor of the breast. 61
32275108 2020
4
[Phyllodes tumor of the breast with heart and lung metastases: a case report]. 61
32146753 2020
5
Giant phyllodes tumor of the breast. 61
31486153 2020
6
Lacrimal Sac Metastasis from Phyllodes Tumor of the Breast. 61
32037753 2020
7
Phyllodes Tumor of the Breast: A Clinicopathological Evaluation of 55 Cases. 61
31912011 2020
8
[Phyllodes Tumor of the Breast Occurring near Postoperative Fibroadenoma Scar-A Case Report]. 61
32381888 2020
9
Radiotherapy with apatinib for recurrence of malignant phyllodes tumor of the breast: A case report. 61
32011486 2020
10
Malignant Phyllodes Tumor of the Breast in a 26-year-old Woman. 61
32051802 2020
11
Comparison of mutation profile between primary phyllodes tumors of the breast and their paired local recurrences. 61
32429649 2020
12
The response of phyllodes tumor of the breast to anticancer therapy: An in vitro and ex vivo study. 61
31612021 2019
13
A rare case of a malignant phyllodes tumor of the breast associated with secretion of beta-human chorionic gonadotropin. 61
31192485 2019
14
Transcatheter arterial chemoembolization improves the resectability of malignant breast phyllodes tumor with angiosarcoma component: a case report. 61
31351458 2019
15
Cytologic diagnosis of metastatic malignant phyllodes tumor of the breast in pleural effusion. 61
30829462 2019
16
Malignant phyllodes tumor of the breast with liposarcomatous differentiation: A case report with imaging findings. 61
30834064 2019
17
Phyllodes tumors of the breast. The treatment results for 340 patients from a single cancer centre. 61
30521986 2019
18
Not Every Fat-Containing Lesion on Mammogram is a Benign Finding: Case Report and Review of Breast Malignant Phyllodes Tumor with Heterologous Liposarcomatous Differentiation. 61
31448161 2019
19
Recurrent borderline phyllodes tumor of the breast submitted to mastectomy and immediate reconstruction: Case report. 61
31195364 2019
20
Phyllodes tumor of the breast: diagnosis, management and outcome during a 10-year experience. 61
31695485 2019
21
Phyllodes tumor of the breast with nipple discharge: A case report. 61
30593154 2018
22
Percutaneous removal of benign phyllodes tumor of the breast: An alternative to surgery. 61
30251456 2018
23
Radiopathological characteristics and outcomes of phyllodes tumor of the breast in Malaysian women. 61
30075507 2018
24
Metastatic giant malignant phyllodes tumor of the breast. 61
29139587 2018
25
Phyllodes Tumor of the Breast: Ultrasound-Pathology Correlation. 61
29412020 2018
26
Early stage malignant phyllodes tumor case report. 61
29247967 2018
27
Malignant Phyllodes Tumor of the Breast with Metastasis to the Pancreas: A Case Report and Review of Literature. 61
30050709 2018
28
Recurrent malignant phyllodes tumor of the breast: A case report. 61
29245318 2017
29
Phyllodes tumor masquerading as a fungating breast mass. 61
29250309 2017
30
A rare presentation of malignant phyllodes tumor with bloody nipple discharge-report of a case. 61
28861384 2017
31
Radiation therapy for malignant phyllodes tumor of the breast: An analysis of SEER data. 61
28013032 2017
32
Giant phyllodes tumor of the breast with diffuse myxoid changes in an adolescent girl: a case report. 61
28458828 2017
33
Multiple metastatic malignant phyllodes tumor of the breast with tonsillar metastasis: a case report. 61
28103951 2017
34
A giant phyllodes tumor of the breast causing severe disfigurement. A case report. 61
28406095 2017
35
Clinicopathology and treatment of a giant malignant phyllodes tumor of the breast: A case report and literature review. 61
29121581 2017
36
Phyllodes Tumor of the Breast: Analysis of 48 Patients. 61
28331755 2016
37
A Giant Phyllodes Tumor of the Breast. 61
27746880 2016
38
A Case of Giant Borderline Phyllodes Tumor of the Breast Associated with Hypoglycemia. 61
27628602 2016
39
Insulin-like growth factor II messenger RNA-binding protein-3 is an indicator of malignant phyllodes tumor of the breast. 61
27137988 2016
40
Breast malignant phyllodes tumor with rare pelvic metastases and long-term overall survival: A case report and literature review. 61
27661051 2016
41
Giant malignant phyllodes tumor of the breast: A rare case report and literature review. 61
27347111 2016
42
Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates. 61
27362571 2016
43
Benign Phyllodes Tumor of the Breast Diagnosed After Ultrasound-Guided Vacuum-Assisted Biopsy: Surgical Excision or Wait-and-Watch? 61
26577125 2016
44
Treatment of Patients with Distant Metastases from Phyllodes Tumor of the Breast. 61
26464157 2016
45
The largest and neglected giant phyllodes tumor of the breast-A case report and literature review. 61
27475116 2016
46
"Ruptured" malignant phyllodes tumor of the breast: a case report. 61
26952179 2016
47
Coexistence of malignant phyllodes tumor and her2-positive locally advanced breast cancer in distinct breasts: A case report. 61
26773878 2016
48
Multiplatform molecular profiling identifies potentially targetable biomarkers in malignant phyllodes tumors of the breast. 61
26625196 2016
49
Phyllodes Tumor of the Breast: 307 Treated Cases, the Largest Mexican Experience at a Single Breast Disease Institution. 61
28855932 2016
50
Metastatic Malignant Phyllodes Tumor of the Breast: An Aggressive Disease-Analysis of 7 Cases. 61
27065662 2015
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Variations for Breast Malignant Phyllodes Tumor

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Expression for Breast Malignant Phyllodes Tumor

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Search GEO for disease gene expression data for Breast Malignant Phyllodes Tumor.
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Pathways for Breast Malignant Phyllodes Tumor

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Pathways related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Pathways in cancer 36
12.49 TP53 KIT ESR1 ERBB2 EGFR
2
Downstream signaling events of B Cell Receptor (BCR) 65
Show member pathways
 12.48 TP53 KIT ERBB2 EGFR
3
Glioma 36
Show member pathways
 12.42 TP53 ESR1 ERBB2 EGFR
4
Gastric cancer 36
Show member pathways
 12.1 TP53 PGR KIT ESR1 ERBB2 EGFR
5
Proteoglycans in cancer 36
11.93 TP53 ESR1 ERBB2 EGFR
6
Tyrosine Kinases / Adaptors 4
11.89 KIT ERBB2 EGFR
7
MAPK Pathway 70
Show member pathways
 11.78 TP53 ERBB2 EGFR
8
Thyroid hormone signaling pathway 36
11.75 TP53 MED12 ESR1
9
Hematopoietic Stem Cells and Lineage-specific Markers 64
11.72 MME KIT CD34
10
Hematopoietic cell lineage 36
11.63 MME KIT CD34
11
Signaling by ERBB4 65
Show member pathways
 11.59 PGR ESR1 ERBB2 EGFR
12
Dendritic Cells Developmental Lineage Pathway 64
11.48 MME KIT CD34
13
Bladder cancer 36 1
11.44 TP53 ERBB2 EGFR
14
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 65
Show member pathways
 11.43 KIT ESR1 ERBB2 EGFR
15
Central carbon metabolism in cancer 36
10.77 TP53 KIT ERBB2 EGFR
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GO Terms for Breast Malignant Phyllodes Tumor

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Cellular components related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basal plasma membrane GO:0009925 8.8 ERBB2 EGFR CD34

Biological processes related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.91 TP53 PGR MED12 KMT2D ESR1 EGFR
2 negative regulation of gene expression GO:0010629 9.76 TP53 PGR ESR1 CD34
3 peptidyl-tyrosine phosphorylation GO:0018108 9.73 KIT ERBB2 EGFR
4 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.72 KIT ERBB2 EGFR
5 replicative senescence GO:0090399 9.54 TP53 MME
6 positive regulation of kinase activity GO:0033674 9.54 KIT ERBB2 EGFR
7 positive regulation of phospholipase C activity GO:0010863 9.52 KIT ESR1
8 tongue development GO:0043586 9.51 KIT EGFR
9 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.49 TP53 EGFR
10 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.48 TP53 ESR1
11 regulation of transcription by RNA polymerase II GO:0006357 9.43 TP53 MED12 KIT ESR1 ERBB2 EGFR
12 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.4 TP53 ESR1
13 positive regulation of MAP kinase activity GO:0043406 9.33 KIT ERBB2 EGFR
14 paracrine signaling GO:0038001 9.32 PGR CD34
15 negative regulation of ERBB signaling pathway GO:1901185 9.26 ERBB2 EGFR
16 positive regulation of protein kinase B signaling GO:0051897 8.92 KIT ESR1 ERBB2 EGFR

Molecular functions related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.67 TP53 PGR ESR1 EGFR
2 transcription factor binding GO:0008134 9.62 TP53 MED12 ESR1 CD34
3 protein tyrosine kinase activity GO:0004713 9.58 KIT ERBB2 EGFR
4 protein phosphatase binding GO:0019903 9.43 TP53 ERBB2 EGFR
5 ATPase binding GO:0051117 9.33 PGR ESR1 EGFR
6 nitric-oxide synthase regulator activity GO:0030235 8.96 ESR1 EGFR
7 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.8 KIT ERBB2 EGFR
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Sources for Breast Malignant Phyllodes Tumor

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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