Breast Malignant Phyllodes Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BRS007 MIFTS: 45	Breast Malignant Phyllodes Tumor Categories: Cancer diseases, Rare diseases, Reproductive diseases
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Aliases & Classifications for Breast Malignant Phyllodes Tumor

MalaCards integrated aliases for Breast Malignant Phyllodes Tumor:

Name: Breast Malignant Phyllodes Tumor ¹² ¹⁵

Cystosarcoma Phyllodes of the Breast ²⁰ ⁵⁸

Malignant Phyllodes Tumor of Breast ¹² ⁷¹

Malignant Cystosarcoma Phyllodes ¹² ⁷¹

Phyllodes Tumor of the Breast ²⁰ ⁵⁸

Phyllodes Breast Tumor ¹² ²⁰

Malignant Phyllodes Tumour of Breast ¹²

Malignant Mammary Phyllodes Tumour ¹²

Breast Malignant Phyllodes Tumour ¹²

Malignant Mammary Phyllodes Tumor ¹²

Malignant Breast Phyllodes Tumor ¹⁷

Malignant Phyllodes Neoplasm ¹²

Malignant Phyllodes Tumour ¹²

Phyllodes Tumor, Malignant ¹²

Malignant Phyllodes Tumor ¹²

Phyllodes Breast Neoplasm ¹²

Phyllodes Breast Tumour ¹²

Cystosarcoma Phyllodes ²⁰

Breast Phyllodes Tumor ⁷¹

Phylloides Tumor ²⁰

Phyllodes Tumor ⁷¹

Characteristics:

Orphanet epidemiological data:

⁵⁸

phyllodes tumor of the breast
Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Neoplasms

Neoplasms of uncertain or unknown behaviour

Neoplasm of uncertain or unknown behaviour of other and unspecified sites

Neoplasm of uncertain or unknown behaviour: Breast

Orphanet: ⁵⁸

Rare gynaecological and obstetric diseases

External Ids:

Disease Ontology ¹² DOID:3016

MeSH ⁴⁴ D003557

NCIt ⁵⁰ C4275 C4504 C7575

SNOMED-CT ⁶⁷ 254844000 712989008 87913009

MESH via Orphanet ⁴⁵ D003557

ICD10 via Orphanet ³³ D48.6

UMLS via Orphanet ⁷² C0010701

Orphanet ⁵⁸ ORPHA180261

EFO ¹⁷ EFO_0008545

UMLS ⁷¹ C0010701 C0238031 C0346154 more

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Summaries for Breast Malignant Phyllodes Tumor

GARD : ²⁰ Phyllodes tumors of the breast are rare tumors that start in the connective (stromal) tissue of the breast. They get their name from the leaf-like pattern in which they grow (phyllodes means leaf-like in Greek). They are most common in women in their 30s and 40s, although women of any age can be affected. These tumors, which are usually painless, tend to grow quickly, but rarely spread outside of the breast. Most phyllodes tumors are benign. About 1 in 10 are cancerous. The underlying cause of these tumors in unknown. Surgery is the main treatment. Because the tumors can reoccur if they are not removed with enough surrounding tissue, the tumor and at least 1 cm of tissue should be removed. Cancerous phyllodes tumors are often treated with mastectomy. Close follow-up with frequent breast examinations are recommended after surgery.

MalaCards based summary : Breast Malignant Phyllodes Tumor, also known as cystosarcoma phyllodes of the breast, is related to li-fraumeni syndrome and scirrhous adenocarcinoma. An important gene associated with Breast Malignant Phyllodes Tumor is MED12 (Mediator Complex Subunit 12), and among its related pathways/superpathways are Developmental Biology and MAPK signaling pathway. Affiliated tissues include breast, pancreas and lymph node, and related phenotypes are cellular and behavior/neurological

Disease Ontology : ¹² A breast cancer that is characterized by a prominent infiltrative border, unequivocal sarcomatous areas, and stromal overgrowth and arises from the stroma, lined by an epithelial and myoepithelial bilayer, forming a leaflike structure. They tend to grow rapidly and present in middle-aged women (40s-50s).

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Related Diseases for Breast Malignant Phyllodes Tumor

Diseases in the Benign Breast Phyllodes Tumor family:

Breast Malignant Phyllodes Tumor

Diseases related to Breast Malignant Phyllodes Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 554)

#	Related Disease	Score	Top Affiliating Genes
1	li-fraumeni syndrome	31.2	TP53 ESR1 ERBB2 EGFR
2	scirrhous adenocarcinoma	30.6	PGR ERBB2
3	prostate sarcoma	30.6	PGR CD34
4	gynecomastia	30.5	PGR ESR1 ERBB2
5	spindle cell sarcoma	30.5	SERPINA3 KIT CD34
6	malignant mesenchymoma	30.4	SERPINA3 CD34
7	fibrous histiocytoma	30.3	SERPINA3 KIT CD34
8	soft tissue sarcoma	30.3	TP53 EGFR
9	malignant fibrous histiocytoma	30.3	TP53 SERPINA3 KIT
10	benign breast phyllodes tumor	30.3	PGR MME KIT CD34
11	breast fibroadenoma	30.2	TP53 SERPINA3 PGR MME MED12 ESR1
12	papillary carcinoma	30.1	PGR ESR1 ERBB2
13	well-differentiated liposarcoma	30.1	TP53 SERPINA3 KIT CD34
14	bilateral breast cancer	30.1	PGR ESR1 ERBB2
15	angiosarcoma	30.0	TP53 KIT CD34
16	embryonal sarcoma	30.0	TP53 SERPINA3 KIT
17	neurilemmoma	30.0	SERPINA3 KIT CD34
18	acute megakaryocytic leukemia	29.9	TP53 KIT CD34
19	hypertrophy of breast	29.9	TP53 PGR ESR1 ERBB2
20	female breast cancer	29.9	TP53 PGR ESR1 ERBB2
21	deficiency anemia	29.8	SERPINA3 MME KIT CD34
22	intraductal papilloma	29.8	PGR KRT5 ESR1 ERBB2
23	mammary paget's disease	29.6	PGR ESR1 ERBB2 EGFR
24	lobular neoplasia	29.6	TP53 PGR KRT5 ESR1 ERBB2
25	adenocarcinoma	29.5	TP53 KIT ERBB2 EGFR
26	prostatic hypertrophy	29.5	SERPINA3 PGR ESR1 EGFR
27	mesenchymal cell neoplasm	29.5	TP53 SERPINA3 MME KIT CD34
28	papilloma	29.5	TP53 KRT5 ERBB2 EGFR
29	leiomyosarcoma	29.4	TP53 SERPINA3 PGR MED12 KIT ESR1
30	inflammatory breast carcinoma	29.4	PGR ESR1 ERBB2 EGFR
31	tubular adenocarcinoma	29.4	PGR MME ESR1 ERBB2 EGFR
32	leiomyoma	29.3	PGR MME MED12 KIT ESR1 CD34
33	breast disease	29.3	TP53 SERPINA3 PGR KRT5 ESR1 ERBB2
34	cribriform carcinoma	29.3	PGR KRT5 KIT ESR1 ERBB2
35	breast sarcoma	29.3	TP53 PGR MME KRT5 ERBB2 CD34
36	breast adenocarcinoma	29.0	TP53 SERPINA3 PGR ESR1 ERBB2 EGFR
37	in situ carcinoma	28.9	TP53 SERPINA3 PGR KRT5 ESR1 ERBB2
38	adenosarcoma	28.8	TP53 SERPINA3 PGR MME KIT ESR1
39	carcinosarcoma	28.8	TP53 PGR MME KIT ERBB2 EGFR
40	microglandular adenosis	28.6	TP53 PGR KIT ESR1 ERBB2 EGFR
41	rhabdomyosarcoma	28.6	TP53 MME KIT ESR1 ERBB2 EGFR
42	ductal carcinoma in situ	28.5	TP53 PGR MME KRT5 ESR1 ERBB2
43	benign prostate phyllodes tumor	11.2
44	li-fraumeni syndrome 2	11.2
45	rare tumor	10.6
46	overgrowth syndrome	10.6
47	liposarcoma	10.4
48	rare breast tumor	10.4
49	fibromatosis	10.4
50	diffuse peritoneal leiomyomatosis	10.4	PGR MED12

Graphical network of the top 20 diseases related to Breast Malignant Phyllodes Tumor:

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Symptoms & Phenotypes for Breast Malignant Phyllodes Tumor

MGI Mouse Phenotypes related to Breast Malignant Phyllodes Tumor:

⁴⁶ (show all 15)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.22	CD34 EGFR ERBB2 ESR1 KIT KMT2D
2	behavior/neurological	MP:0005386	10.2	ERBB2 ESR1 KIT KMT2D KRT5 MME
3	cardiovascular system	MP:0005385	10.19	EGFR ERBB2 ESR1 KIT KMT2D MED12
4	homeostasis/metabolism	MP:0005376	10.16	CD34 EGFR ERBB2 ESR1 KIT KMT2D
5	integument	MP:0010771	10.14	CD34 EGFR ERBB2 ESR1 KIT KMT2D
6	immune system	MP:0005387	10.09	CD34 EGFR ESR1 KIT KMT2D KRT5
7	embryo	MP:0005380	10.08	EGFR ERBB2 ESR1 KIT KMT2D MED12
8	craniofacial	MP:0005382	10.05	EGFR ERBB2 KIT KMT2D KRT5 MED12
9	digestive/alimentary	MP:0005381	9.97	EGFR ERBB2 ESR1 KIT KRT5 TP53
10	limbs/digits/tail	MP:0005371	9.97	EGFR ERBB2 ESR1 KIT KRT5 MED12
11	muscle	MP:0005369	9.87	EGFR ERBB2 ESR1 KIT KMT2D PGR
12	neoplasm	MP:0002006	9.86	CD34 EGFR ERBB2 ESR1 KIT KMT2D
13	normal	MP:0002873	9.7	EGFR ERBB2 ESR1 KIT MED12 PGR
14	respiratory system	MP:0005388	9.43	EGFR ERBB2 ESR1 KIT KMT2D TP53
15	skeleton	MP:0005390	9.23	EGFR ERBB2 ESR1 KIT KMT2D MED12

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Drugs & Therapeutics for Breast Malignant Phyllodes Tumor

Interventional clinical trials:

#	Name	Status	NCT ID
1	A Prospective Study of Adjuvant Radiation Therapy After Resection of Borderline and Malignant Phyllodes Tumors	Completed	NCT00003404
2	A Prospective Study of Partial Breast Adjuvant Radiation Therapy After Resection of Borderline and Malignant Phyllodes Tumors	Recruiting	NCT01089374
3	Pilot Study on the Feasibility of Cryotherapy as an Alternative Treatment for Phyllodes Tumors/Breast Fibroepithelial Lesions (FELs) Needing Surgery	Recruiting	NCT04571307

Search NIH Clinical Center for Breast Malignant Phyllodes Tumor

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Genetic Tests for Breast Malignant Phyllodes Tumor

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Anatomical Context for Breast Malignant Phyllodes Tumor

MalaCards organs/tissues related to Breast Malignant Phyllodes Tumor:

⁴⁰

Breast, Pancreas, Lymph Node, Kidney, Skin, Tonsil

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Publications for Breast Malignant Phyllodes Tumor

Articles related to Breast Malignant Phyllodes Tumor:

(show top 50) (show all 242)

#	Title	Authors	PMID	Year
1	Outcomes of systemic therapy in metastatic phyllodes tumor of the breast. ⁶¹	Parkes A...Ratan R	33575859	2021
2	The role of adjuvant radiotherapy in patients with malignant phyllodes tumor of the breast: a propensity-score matching analysis. ⁶¹	Zhao W...Yang J	32748225	2021
3	Pancreatic metastasis from malignant phyllodes tumor of the breast. ⁶¹	Lee SE...Choi JH	33242383	2021
4	Granulocyte-colony stimulating factor-producing malignant phyllodes tumor of the breast: a rare case. ⁶¹	Mizoguchi K...Taniguchi M	33447858	2021
5	Malignant Phyllodes Tumor of the Breast With Metastasis to the Orbit: A Rare Case Report. ⁶¹	Vempuluru VS...Kaliki S	32732545	2021
6	Non-invasive ductal carcinoma within malignant phyllodes tumor of the breast. ⁶¹	Erdogan O...Irkorucu O	33473040	2021
7	Phyllodes tumor of the breast clinical experience and outcomes: A retrospective cohort tertiary hospital experience. ⁶¹	Alkushi A...Omair A	33472142	2021
8	[Study of Phyllodes Tumor of the Breast in 44 Cases of Resection]. ⁶¹	Miyoshi T...Yoshioka S	33468770	2020
9	Giant malignant phyllodes tumor of the breast: Insights into optimal management and reconstructive options for a rare and challenging entity. ⁶¹	Lissidini G...Veronesi P	33108821	2020
10	Malignant phyllodes tumor of the breast with rapid progression: a case report. ⁶¹	Abe H...Yoneda G	33284362	2020
11	World's Oldest Case of Synchronous Bilateral Benign Phyllodes Tumors of the Breast: A Rare Occurrence. ⁶¹	Islam S...Naraynsingh V	33520491	2020
12	Early-onset malignant phyllodes breast tumor in a patient with germline pathogenic variants in NF1 and BRCA1 genes. ⁶¹	Gensini F...Papi L	33210232	2020
13	Malignant phyllodes tumor with extensive lipomatous differentiation. ⁶¹	Landy J...Kaufman T	32994850	2020
14	En Bloc Excision of Phyllodes Tumor of the Breast: Radical Approach Heralds Better Outcome. ⁶¹	Nair NS...Badwe RA	33046357	2020
15	Phyllodes Tumor of the Breast during Pregnancy and Lactation; A Systematic Review. ⁶¹	Alipour S...Furuya S	32657600	2020
16	Patterns of care and predictors of adjuvant radiation therapy in phyllodes tumor of the breast. ⁶¹	Oladeru OT...Warren LE	32275108	2020
17	ASO Author Reflections: How Far Should We Go in Local Management for a Localized Malignant Phyllodes Tumor of the Breast? ⁶¹	Neron M...Firmin N	32206956	2020
18	Cutaneous Scalp Metastases of Malignant Phyllodes Tumor of the Breast. ⁶¹	Lee HJ...Park MH	32595994	2020
19	The Reconstruction after a Giant Phyllodes Tumor Resection Using a DIEP Flap. ⁶¹	Tsuruta Y...Yano T	32440428	2020
20	[Phyllodes tumor of the breast with heart and lung metastases: a case report]. ⁶¹	Chen S...Pan J	32146753	2020
21	Giant phyllodes tumor of the breast. ⁶¹	Pascarella S...Reilly K	31486153	2020
22	Lacrimal Sac Metastasis from Phyllodes Tumor of the Breast. ⁶¹	Kim SH...Kang SM	32037753	2020
23	Comparison of mutation profile between primary phyllodes tumors of the breast and their paired local recurrences. ⁶¹	Mitus J...Niemiec J	32429649	2020
24	Radiotherapy with apatinib for recurrence of malignant phyllodes tumor of the breast: A case report. ⁶¹	Wu H...Wang H	32011486	2020
25	Malignant Phyllodes Tumor of the Breast in a 26-year-old Woman. ⁶¹	Nguyen NT...Nguyen QD	32051802	2020
26	Pancreatic metastases and first reported gallbladder metastasis from phyllodes tumor of the breast. ⁶¹	Nasri S...Elghali MA	33282161	2020
27	Phyllodes Tumor of the Breast in Pregnancy and Lactation. ⁶¹	Alipour S...Eskandari A	32816274	2020
28	Immunohistochemical detection of paralogous 13 HOX genes in phyllodes tumor of the breast as a useful diagnostic tool. ⁶¹	Sarno S...Di Bonito M	33042341	2020
29	[Phyllodes Tumor of the Breast Occurring near Postoperative Fibroadenoma Scar-A Case Report]. ⁶¹	Sakurai K...Fujisaki S	32381888	2020
30	Phyllodes Tumor of the Breast: A Clinicopathological Evaluation of 55 Cases. ⁶¹	Hasdemir S...Gokgoz MS	31912011	2020
31	The response of phyllodes tumor of the breast to anticancer therapy: An in vitro and ex vivo study. ⁶¹	Urbaniak A...Chambers TC	31612021	2019
32	A rare case of a malignant phyllodes tumor of the breast associated with secretion of beta-human chorionic gonadotropin. ⁶¹	Andring L...Deraniyagala R	31192485	2019
33	Transcatheter arterial chemoembolization improves the resectability of malignant breast phyllodes tumor with angiosarcoma component: a case report. ⁶¹	Kuo CY...Tu SH	31351458	2019
34	Cytologic diagnosis of metastatic malignant phyllodes tumor of the breast in pleural effusion. ⁶¹	Li JJX...Tse GM	30829462	2019
35	Malignant phyllodes tumor of the breast with liposarcomatous differentiation: A case report with imaging findings. ⁶¹	Kim JH...Lee JY	30834064	2019
36	Phyllodes tumors of the breast. The treatment results for 340 patients from a single cancer centre. ⁶¹	Mitus JW...Wysocki W	30521986	2019
37	Phyllodes tumor of the breast: diagnosis, management and outcome during a 10-year experience. ⁶¹	Ditsatham C...Chongruksut W	31695485	2019
38	Not Every Fat-Containing Lesion on Mammogram is a Benign Finding: Case Report and Review of Breast Malignant Phyllodes Tumor with Heterologous Liposarcomatous Differentiation. ⁶¹	Soni N...Policeni F	31448161	2019
39	Recurrent borderline phyllodes tumor of the breast submitted to mastectomy and immediate reconstruction: Case report. ⁶¹	Garlet BB...Krahe FD	31195364	2019
40	Phyllodes tumor of the breast with nipple discharge: A case report. ⁶¹	Jing P...Yang X	30593154	2018
41	Percutaneous removal of benign phyllodes tumor of the breast: An alternative to surgery. ⁶¹	Grana Lopez L...Villares Armas A	30251456	2018
42	Radiopathological characteristics and outcomes of phyllodes tumor of the breast in Malaysian women. ⁶¹	Abdul Hamid S...Taib NAM	30075507	2018
43	Metastatic giant malignant phyllodes tumor of the breast. ⁶¹	Sanchez AM...Masetti R	29139587	2018
44	Phyllodes Tumor of the Breast: Ultrasound-Pathology Correlation. ⁶¹	Kalambo M...Whitman GJ	29412020	2018
45	Early stage malignant phyllodes tumor case report. ⁶¹	Wolbert T...Legenza M	29247967	2018
46	Malignant Phyllodes Tumor of the Breast with Metastasis to the Pancreas: A Case Report and Review of Literature. ⁶¹	Amir RA...Sheikh SS	30050709	2018
47	Phyllodes tumor masquerading as a fungating breast mass. ⁶¹	Bruce NR...Henry-Tillman R	29250309	2017
48	Recurrent malignant phyllodes tumor of the breast: A case report. ⁶¹	Wang Q...Lei Y	29245318	2017
49	A rare presentation of malignant phyllodes tumor with bloody nipple discharge-report of a case. ⁶¹	Chen WH	28861384	2017
50	Radiation therapy for malignant phyllodes tumor of the breast: An analysis of SEER data. ⁶¹	Kim YJ...Kim K	28013032	2017

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Genes for Breast Malignant Phyllodes Tumor

Genes related to Breast Malignant Phyllodes Tumor (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MED12	Mediator Complex Subunit 12	Protein Coding	7.35	DISEASES inferred ¹⁵
2	SERPINA3	Serpin Family A Member 3	Protein Coding	6.68	DISEASES inferred ¹⁵ ¹⁵
3	PGR	Progesterone Receptor	Protein Coding	6.38	DISEASES inferred ¹⁵
4	CD34	CD34 Molecule	Protein Coding	6.32	DISEASES inferred ¹⁵
5	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	6.23	DISEASES inferred ¹⁵
6	TP53	Tumor Protein P53	Protein Coding	6.22	DISEASES inferred ¹⁵
7	KRT5	Keratin 5	Protein Coding	6.21	DISEASES inferred ¹⁵
8	MME	Membrane Metalloendopeptidase	Protein Coding	6.06	DISEASES inferred ¹⁵
9	ESR1	Estrogen Receptor 1	Protein Coding	6.05	DISEASES inferred ¹⁵
10	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	5.83	DISEASES inferred ¹⁵
11	EGFR	Epidermal Growth Factor Receptor	Protein Coding	5.52	DISEASES inferred ¹⁵
12	KMT2D	Lysine Methyltransferase 2D	Protein Coding	5.37	DISEASES inferred ¹⁵

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Variations for Breast Malignant Phyllodes Tumor

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Expression for Breast Malignant Phyllodes Tumor

Search GEO for disease gene expression data for Breast Malignant Phyllodes Tumor.

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Pathways for Breast Malignant Phyllodes Tumor

Pathways related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

(show all 18)

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁵ Show member pathways Axon guidance ⁶⁵	13.24	MED12 KRT5 KMT2D KIT ERBB2 EGFR
2	MAPK signaling pathway ³⁶ ¹	12.53	TP53 KIT ERBB2 EGFR
3	Pathways in cancer ³⁶	12.49	TP53 KIT ESR1 ERBB2 EGFR
4	Downstream signaling events of B Cell Receptor (BCR) ⁶⁵ Show member pathways Activation of RAS in B cells ⁶⁵ Signaling by the B Cell Receptor (BCR) ⁶⁵	12.48	TP53 KIT ERBB2 EGFR
5	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.43	TP53 ESR1 ERBB2 EGFR
6	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.1	TP53 PGR KIT ESR1 ERBB2 EGFR
7	Integrated Breast Cancer Pathway ¹	11.94	TP53 ESR1 EGFR
8	Proteoglycans in cancer ³⁶	11.93	TP53 ESR1 ERBB2 EGFR
9	Tyrosine Kinases / Adaptors ⁴	11.9	KIT ERBB2 EGFR
10	MAPK Pathway ⁷⁰ Show member pathways Toll-like Receptor Pathway ⁷⁰	11.78	TP53 ERBB2 EGFR
11	Thyroid hormone signaling pathway ³⁶	11.75	TP53 MED12 ESR1
12	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.72	MME KIT CD34
13	Hematopoietic cell lineage ³⁶	11.63	MME KIT CD34
14	Signaling by ERBB4 ⁶⁵ Show member pathways Downregulation of ERBB4 signaling ⁶⁵ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁵	11.59	PGR ESR1 ERBB2 EGFR
15	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.48	MME KIT CD34
16	Bladder cancer ³⁶ ¹	11.44	TP53 ERBB2 EGFR
17	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors ⁶⁵ Show member pathways Activation of the TFAP2 (AP-2) family of transcription factors ⁶⁵ Negative regulation of activity of TFAP2 (AP-2) family transcription factors ⁶⁵ TFAP2 (AP-2) family regulates transcription of cell cycle factors ⁶⁵ TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ⁶⁵ TFAP2 (AP-2) family regulates transcription of other transcription factors ⁶⁵ TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation ⁶⁵	11.43	KIT ESR1 ERBB2 EGFR
18	Central carbon metabolism in cancer ³⁶	10.77	TP53 KIT ERBB2 EGFR

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GO Terms for Breast Malignant Phyllodes Tumor

Cellular components related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	basal plasma membrane	GO:0009925	8.8	ERBB2 EGFR CD34

Biological processes related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	9.88	TP53 PGR MED12 KMT2D ESR1 EGFR
2	peptidyl-tyrosine phosphorylation	GO:0018108	9.74	KIT ERBB2 EGFR
3	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.73	KIT ERBB2 EGFR
4	negative regulation of gene expression	GO:0010629	9.73	TP53 PGR ESR1 CD34
5	regulation of transcription by RNA polymerase II	GO:0006357	9.7	TP53 PGR MED12 KIT ESR1 ERBB2
6	replicative senescence	GO:0090399	9.55	TP53 MME
7	positive regulation of phospholipase C activity	GO:0010863	9.54	KIT ESR1
8	positive regulation of kinase activity	GO:0033674	9.54	KIT ERBB2 EGFR
9	positive regulation of production of miRNAs involved in gene silencing by miRNA	GO:1903800	9.52	TP53 EGFR
10	negative regulation of production of miRNAs involved in gene silencing by miRNA	GO:1903799	9.51	TP53 ESR1
11	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	GO:0045899	9.49	TP53 ESR1
12	tongue development	GO:0043586	9.48	KIT EGFR
13	intracellular steroid hormone receptor signaling pathway	GO:0030518	9.46	PGR ESR1
14	paracrine signaling	GO:0038001	9.32	PGR CD34
15	negative regulation of ERBB signaling pathway	GO:1901185	9.26	ERBB2 EGFR
16	positive regulation of MAP kinase activity	GO:0043406	9.13	KIT ERBB2 EGFR
17	positive regulation of protein kinase B signaling	GO:0051897	8.92	KIT ESR1 ERBB2 EGFR

Molecular functions related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromatin binding	GO:0003682	9.73	TP53 MED12 ESR1 EGFR
2	enzyme binding	GO:0019899	9.67	TP53 PGR ESR1 EGFR
3	transcription factor binding	GO:0008134	9.62	TP53 MED12 ESR1 CD34
4	protein tyrosine kinase activity	GO:0004713	9.58	KIT ERBB2 EGFR
5	protein phosphatase binding	GO:0019903	9.43	TP53 ERBB2 EGFR
6	ATPase binding	GO:0051117	9.33	PGR ESR1 EGFR
7	nitric-oxide synthase regulator activity	GO:0030235	8.96	ESR1 EGFR
8	transmembrane receptor protein tyrosine kinase activity	GO:0004714	8.8	KIT ERBB2 EGFR

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Sources for Breast Malignant Phyllodes Tumor

¹ BioSystems

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⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

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⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia