MCID: BRS007
MIFTS: 33

Breast Malignant Phyllodes Tumor

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Breast Malignant Phyllodes Tumor

MalaCards integrated aliases for Breast Malignant Phyllodes Tumor:

Name: Breast Malignant Phyllodes Tumor 12 15
Malignant Phyllodes Tumor of Breast 12 74
Malignant Cystosarcoma Phyllodes 12 74
Phyllodes Tumor of the Breast 54 60
Phyllodes Breast Tumor 12 54
Cystosarcoma Phyllodes of the Breast 60
Malignant Mammary Phyllodes Tumor 12
Malignant Breast Phyllodes Tumor 17
Malignant Phyllodes Neoplasm 12
Phyllodes Tumor, Malignant 12
Malignant Phyllodes Tumor 12
Phyllodes Breast Neoplasm 12
Cystosarcoma Phyllodes 54
Breast Phyllodes Tumor 74
Phylloides Tumor 54
Phyllodes Tumor 74

Characteristics:

Orphanet epidemiological data:

60
phyllodes tumor of the breast
Age of onset: Adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:3016
MeSH 45 D003557
SNOMED-CT 69 87913009
MESH via Orphanet 46 D003557
ICD10 via Orphanet 35 D48.6
UMLS via Orphanet 75 C0010701
Orphanet 60 ORPHA180261

Summaries for Breast Malignant Phyllodes Tumor

NIH Rare Diseases : 54 Phyllodes tumors of the breast are rare tumors that start in the connective (stromal) tissue of the breast. They get their name from the leaf-like pattern in which they grow (phyllodes means leaf-like in Greek). They are most common in women in their 30s and 40s, although women of any age can be affected. These tumors, which are usually painless, tend to grow quickly, but rarely spread outside of the breast. Most phyllodes tumors are benign. About 1 in 10 are cancerous. The underlying cause of these tumors in unknown. Surgery is the main treatment. Because the tumors can reoccur if they are not removed with enough surrounding tissue, the tumor and at least 1 cm of tissue should be removed. Cancerous phyllodes tumors are often treated with mastectomy. Close follow-up with frequent breast examinations are recommended after surgery.   

MalaCards based summary : Breast Malignant Phyllodes Tumor, also known as malignant phyllodes tumor of breast, is related to benign prostate phyllodes tumor and prostate malignant phyllodes tumor. An important gene associated with Breast Malignant Phyllodes Tumor is PTS (6-Pyruvoyltetrahydropterin Synthase), and among its related pathways/superpathways is TP53 Regulates Metabolic Genes. Affiliated tissues include breast, lung and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

Disease Ontology : 12 A breast cancer that is characterized by a prominent infiltrative border, unequivocal sarcomatous areas, and stromal overgrowth and arises_from the stroma, lined by an epithelial and myoepithelial bilayer, forming a leaflike structure. They tend to grow rapidly and present in middle-aged women (40s-50s).

Related Diseases for Breast Malignant Phyllodes Tumor

Diseases in the Benign Breast Phyllodes Tumor family:

Breast Malignant Phyllodes Tumor

Diseases related to Breast Malignant Phyllodes Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 benign prostate phyllodes tumor 11.4
2 prostate malignant phyllodes tumor 11.3
3 li-fraumeni syndrome 11.3
4 li-fraumeni syndrome 2 11.3
5 breast fibroadenoma 10.6
6 benign breast phyllodes tumor 10.5
7 sarcoma 10.5
8 osteogenic sarcoma 10.4
9 infant gynecomastia 10.3
10 gynecomastia 10.3
11 adenocarcinoma 10.3
12 liposarcoma 10.3
13 breast cancer 10.3
14 chondrosarcoma 10.2
15 angiosarcoma 10.2
16 desmoid tumor 10.2
17 malignant fibroxanthoma 10.2
18 fibrosarcoma 10.2
19 scirrhous adenocarcinoma 10.2
20 histiocytoma 10.2
21 fibrous histiocytoma 10.2
22 paraplegia 10.2
23 breast giant fibroadenoma 10.2
24 soft tissue sarcoma 10.2
25 undifferentiated pleomorphic sarcoma 10.2
26 fibromatosis 10.1
27 infantile digital fibromatosis 10.1
28 mixed glioma 10.1 AGO2 TP53
29 hypoglycemia 10.1
30 well-differentiated liposarcoma 10.1
31 mammary paget's disease 10.1
32 adenoma 10.1
33 retroperitoneal leiomyosarcoma 10.0 PGR PTS
34 islet cell tumor 10.0
35 hypoglycemic coma 10.0
36 melanoma 10.0
37 breast disease 10.0
38 cardiogenic shock 10.0
39 neurilemmoma 10.0
40 endometrium carcinoma in situ 10.0 PGR TP53
41 olfactory groove meningioma 10.0 PGR TP53
42 intussusception 10.0
43 aneurysmal bone cysts 10.0
44 analbuminemia 10.0
45 breast reconstruction 10.0
46 leukemia 10.0
47 megakaryocytic leukemia 10.0
48 cribriform carcinoma 10.0
49 breast liposarcoma 10.0
50 pleomorphic liposarcoma 10.0

Graphical network of the top 20 diseases related to Breast Malignant Phyllodes Tumor:



Diseases related to Breast Malignant Phyllodes Tumor

Symptoms & Phenotypes for Breast Malignant Phyllodes Tumor

MGI Mouse Phenotypes related to Breast Malignant Phyllodes Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 AGO2 HSD11B2 NEK8 PGR PTS TP53
2 homeostasis/metabolism MP:0005376 9.63 AGO2 HSD11B2 NEK8 PGR PTS TP53
3 mortality/aging MP:0010768 9.43 AGO2 HSD11B2 NEK8 PGR PTS TP53
4 muscle MP:0005369 8.92 HSD11B2 PGR PTS TP53

Drugs & Therapeutics for Breast Malignant Phyllodes Tumor

Search Clinical Trials , NIH Clinical Center for Breast Malignant Phyllodes Tumor

Genetic Tests for Breast Malignant Phyllodes Tumor

Anatomical Context for Breast Malignant Phyllodes Tumor

MalaCards organs/tissues related to Breast Malignant Phyllodes Tumor:

42
Breast, Lung, Kidney

Publications for Breast Malignant Phyllodes Tumor

Articles related to Breast Malignant Phyllodes Tumor:

# Title Authors Year
1
Breast malignant phyllodes tumor with rare pelvic metastases and long-term overall survival: A case report and literature review. ( 27661051 )
2016
2
Pleomorphic liposarcoma arising in a malignant phyllodes tumor of breast: A rare occurrence. ( 26881623 )
2015
3
A Rare Case of Breast Malignant Phyllodes Tumor With Metastases to the Kidney: Case Report. ( 26287414 )
2015
4
Synchronous bilateral primary breast malignant phyllodes tumor and carcinoma of the breast with Paget's disease: a case report and review of the literature. ( 26770378 )
2015
5
Angiosarcoma in recurrent malignant phyllodes tumor of breast. ( 22771666 )
2012
6
Invasive cribriform carcinoma arising in malignant phyllodes tumor of breast: a case report. ( 23110003 )
2012
7
Major response to sunitinib (Sutene) in metastatic malignant phyllodes tumor of breast. ( 19002383 )
2009
8
Malignant phyllodes tumor of breast with lung metastases mimicking the primary. ( 9777991 )
1998

Variations for Breast Malignant Phyllodes Tumor

Expression for Breast Malignant Phyllodes Tumor

Search GEO for disease gene expression data for Breast Malignant Phyllodes Tumor.

Pathways for Breast Malignant Phyllodes Tumor

Pathways related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.55 AGO2 TP53

GO Terms for Breast Malignant Phyllodes Tumor

Cellular components related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.17 AGO2 HSD11B2 NEK8 NT5C1B PGR PTS

Molecular functions related to Breast Malignant Phyllodes Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 8.62 HSD11B2 PGR

Sources for Breast Malignant Phyllodes Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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