MCID: BRS015
MIFTS: 28

Breast Medullary Carcinoma

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Breast Medullary Carcinoma

MalaCards integrated aliases for Breast Medullary Carcinoma:

Name: Breast Medullary Carcinoma 12 15
Medullary Breast Carcinoma with Lymphoid Stroma 12
Medullary Carcinoma of Breast 12
Medullary Breast Carcinoma 17

Classifications:



External Ids:

Disease Ontology 12 DOID:5605
NCIt 49 C9119
UMLS 71 C0860580

Summaries for Breast Medullary Carcinoma

Disease Ontology : 12 A breast adenocarcinoma that is characterized by a syncitial growth pattern and high grade cytology.

MalaCards based summary : Breast Medullary Carcinoma, also known as medullary breast carcinoma with lymphoid stroma, is related to breast ductal carcinoma and rare tumor. An important gene associated with Breast Medullary Carcinoma is LCOR (Ligand Dependent Nuclear Receptor Corepressor). Affiliated tissues include breast.

Wikipedia : 74 Medullary carcinoma of the breast is a type of breast... more...

Related Diseases for Breast Medullary Carcinoma

Diseases related to Breast Medullary Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 breast ductal carcinoma 10.0
2 rare tumor 10.0
3 mulchandani-bhoj-conlin syndrome 9.9
4 squamous cell papilloma 9.9
5 breast fibroadenoma 9.9
6 intraductal papilloma 9.9
7 papilloma 9.9
8 tubular adenocarcinoma 9.9
9 bilateral breast cancer 9.9
10 breast cancer 9.9
11 aspergillosis 9.9
12 malignant fibroxanthoma 9.9
13 breast disease 9.9
14 histiocytoma 9.9
15 fibrous histiocytoma 9.9
16 undifferentiated pleomorphic sarcoma 9.9
17 rare malignant breast tumor 9.9
18 transient neonatal diabetes mellitus 9.6 ZNF57 TRIM28

Graphical network of the top 20 diseases related to Breast Medullary Carcinoma:



Diseases related to Breast Medullary Carcinoma

Symptoms & Phenotypes for Breast Medullary Carcinoma

Drugs & Therapeutics for Breast Medullary Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Medullary Carcinoma

Genetic Tests for Breast Medullary Carcinoma

Anatomical Context for Breast Medullary Carcinoma

MalaCards organs/tissues related to Breast Medullary Carcinoma:

40
Breast

Publications for Breast Medullary Carcinoma

Articles related to Breast Medullary Carcinoma:

(show all 14)
# Title Authors PMID Year
1
Competing Risk Analyses of Medullary Carcinoma of Breast in Comparison to Infiltrating Ductal Carcinoma. 61
31953417 2020
2
Cytomorphological Study of Medullary Carcinoma of Breast in Comparison to Infiltrating Ductal Carcinoma. 61
30498288 2018
3
Synchronous bilateral medullary carcinoma of breast: is it metastasis or second primary? 61
22531532 2012
4
Tumor infiltrating lymphocytes differ in invasive micropapillary carcinoma and medullary carcinoma of breast. 61
18469794 2008
5
Medullary carcinoma of breast with a novel germline mutation 1123T >G in exon 11 of BRCA1. 61
16945238 2006
6
Differential amplification and overexpression of HER-2/neu, p53, MIB1, and estrogen receptor/progesterone receptor among medullary carcinoma, atypical medullary carcinoma, and high-grade invasive ductal carcinoma of breast. 61
14567723 2003
7
Lack of HIN-1 methylation defines specific breast tumor subtypes including medullary carcinoma of the breast and BRCA1-linked tumors. 61
14614327 2003
8
Immunoglobulin repertoire of B lymphocytes infiltrating breast medullary carcinoma. 61
15156099 2003
9
A scFv phage display mini library generated from the immunoglobulin repertoire of breast medullary carcinoma infiltrating B lymphocytes. 61
11360824 2000
10
[Medullary carcinoma of the stomach]. 61
11188855 2000
11
Immunoglobulin variable regions usage by B-lymphocytes infiltrating a human breast medullary carcinoma. 61
10065736 1999
12
Class distribution of immunoglobulin-containing plasma cells in the stroma of medullary carcinoma of breast. 61
3013350 1986
13
Medullary carcinoma of breast: an immunohistochemical study of its lymphoid stroma. 61
6268284 1981
14
Inhibition of leukocyte migration by human breast-cancer-associated antigens. 61
62721 1976

Variations for Breast Medullary Carcinoma

Cosmic variations for Breast Medullary Carcinoma:

9 (show top 50) (show all 327)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM87897832 TP53 breast,NS,carcinoma,medullary carcinoma c.725G>A p.C242Y 17:7674238-7674238 21
2 COSM87898588 TP53 breast,NS,carcinoma,medullary carcinoma c.711G>A p.M237I 17:7674252-7674252 21
3 COSM87900526 TP53 breast,NS,carcinoma,medullary carcinoma c.614A>G p.Y205C 17:7674917-7674917 21
4 COSM87897883 TP53 breast,NS,carcinoma,medullary carcinoma c.659A>G p.Y220C 17:7674872-7674872 21
5 COSM87898758 TP53 breast,NS,carcinoma,medullary carcinoma c.707A>G p.Y236C 17:7674256-7674256 21
6 COSM87899887 TP53 breast,NS,carcinoma,medullary carcinoma c.856G>A p.E286K 17:7673764-7673764 21
7 COSM87900604 TP53 breast,NS,carcinoma,medullary carcinoma c.637C>T p.R213* 17:7674894-7674894 21
8 COSM87903333 TP53 breast,NS,carcinoma,medullary carcinoma c.646G>A p.V216M 17:7674885-7674885 21
9 COSM87897745 TP53 breast,NS,carcinoma,medullary carcinoma c.524G>A p.R175H 17:7675088-7675088 21
10 COSM87898351 TP53 breast,NS,carcinoma,medullary carcinoma c.743G>A p.R248Q 17:7674220-7674220 21
11 COSM87898881 TP53 breast,NS,carcinoma,medullary carcinoma c.578A>G p.H193R 17:7674953-7674953 21
12 COSM87921436 TP53 breast,NS,carcinoma,medullary carcinoma c.1015G>T p.E339* 17:7670694-7670694 21
13 COSM87901584 TP53 breast,NS,carcinoma,medullary carcinoma c.379T>C p.S127P 17:7675233-7675233 21
14 COSM87900980 TP53 breast,NS,carcinoma,medullary carcinoma c.839G>A p.R280K 17:7673781-7673781 21
15 COSM87899842 TP53 breast,NS,carcinoma,medullary carcinoma c.584T>C p.I195T 17:7674947-7674947 21
16 COSM87905366 TP53 breast,NS,carcinoma,medullary carcinoma c.476C>T p.A159V 17:7675136-7675136 21
17 COSM87898605 TP53 breast,NS,carcinoma,medullary carcinoma c.824G>A p.C275Y 17:7673796-7673796 21
18 COSM87132245 PIK3CA breast,NS,carcinoma,medullary c.3140A>G p.H1047R 3:179234297-179234297 21
19 COSM87132308 PIK3CA breast,NS,carcinoma,medullary c.1633G>A p.E545K 3:179218303-179218303 21
20 COSM142560281 breast,NS,carcinoma,medullary carcinoma c.626G>A p.R209Q 17:7674220-7674220 21
21 COSM112254871 breast,NS,carcinoma,medullary carcinoma c.856G>A p.E286K 17:7673764-7673764 21
22 COSM143370595 breast,NS,carcinoma,medullary carcinoma c.407G>A p.R136H 17:7675088-7675088 21
23 COSM105642325 breast,NS,carcinoma,medullary carcinoma c.782+3487G>T p.? 17:7670694-7670694 21
24 COSM122734535 breast,NS,carcinoma,medullary carcinoma c.182A>G p.H61R 17:7674953-7674953 21
25 COSM122734046 breast,NS,carcinoma,medullary carcinoma c.263A>G p.Y88C 17:7674872-7674872 21
26 COSM144086975 breast,NS,carcinoma,medullary carcinoma c.47G>A p.R16H 17:7675088-7675088 21
27 COSM105620035 breast,NS,carcinoma,medullary carcinoma c.659A>G p.Y220C 17:7674872-7674872 21
28 COSM121876255 breast,NS,carcinoma,medullary carcinoma c.315G>A p.M105I 17:7674252-7674252 21
29 COSM144013113 breast,NS,carcinoma,medullary carcinoma c.491G>A p.R164H 17:7675088-7675088 21
30 COSM144015364 breast,NS,carcinoma,medullary carcinoma c.604C>T p.R202* 17:7674894-7674894 21
31 COSM111758247 breast,NS,carcinoma,medullary carcinoma c.524G>A p.R175H 17:7675088-7675088 21
32 COSM121877998 breast,NS,carcinoma,medullary carcinoma c.188T>C p.I63T 17:7674947-7674947 21
33 COSM145018002 breast,NS,carcinoma,medullary carcinoma c.590A>G p.Y197C 17:7674256-7674256 21
34 COSM143943565 breast,NS,carcinoma,medullary carcinoma c.47G>A p.R16H 17:7675088-7675088 21
35 COSM122734176 breast,NS,carcinoma,medullary carcinoma c.347G>A p.R116Q 17:7674220-7674220 21
36 COSM143946000 breast,NS,carcinoma,medullary carcinoma c.137A>G p.Y46C 17:7674917-7674917 21
37 COSM106052917 breast,NS,carcinoma,medullary carcinoma c.524G>A p.R175H 17:7675088-7675088 21
38 COSM144013594 breast,NS,carcinoma,medullary carcinoma c.678G>A p.M226I 17:7674252-7674252 21
39 COSM93185597 breast,NS,carcinoma,medullary carcinoma c.637C>T p.R213* 17:7674894-7674894 21
40 COSM106055977 breast,NS,carcinoma,medullary carcinoma c.379T>C p.S127P 17:7675233-7675233 21
41 COSM121875575 breast,NS,carcinoma,medullary carcinoma c.128G>A p.R43H 17:7675088-7675088 21
42 COSM144650856 breast,NS,carcinoma,medullary carcinoma c.608G>A p.C203Y 17:7674238-7674238 21
43 COSM143156965 breast,NS,carcinoma,medullary carcinoma c.234G>A p.M78I 17:7674252-7674252 21
44 COSM143371322 breast,NS,carcinoma,medullary carcinoma c.461A>G p.H154R 17:7674953-7674953 21
45 COSM144650780 breast,NS,carcinoma,medullary carcinoma c.407G>A p.R136H 17:7675088-7675088 21
46 COSM144650895 breast,NS,carcinoma,medullary carcinoma c.542A>G p.Y181C 17:7674872-7674872 21
47 COSM142561493 breast,NS,carcinoma,medullary carcinoma c.739G>A p.E247K 17:7673764-7673764 21
48 COSM143156843 breast,NS,carcinoma,medullary carcinoma c.266G>A p.R89Q 17:7674220-7674220 21
49 COSM142838326 breast,NS,carcinoma,medullary carcinoma c.856G>A p.E286K 17:7673764-7673764 21
50 COSM143944324 breast,NS,carcinoma,medullary carcinoma c.101A>G p.H34R 17:7674953-7674953 21

Expression for Breast Medullary Carcinoma

Search GEO for disease gene expression data for Breast Medullary Carcinoma.

Pathways for Breast Medullary Carcinoma

GO Terms for Breast Medullary Carcinoma

Cellular components related to Breast Medullary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear matrix GO:0016363 8.96 ZNF350 PHB2
2 intracellular GO:0005622 8.92 ZNF57 ZNF350 ZNF274 TRIM28

Biological processes related to Breast Medullary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.33 ZNF350 TRIM28 PHB2
2 regulation of complement activation GO:0030449 8.96 PHB2 CD55
3 negative regulation of nucleic acid-templated transcription GO:1903507 8.62 ZNF274 TRIM28

Molecular functions related to Breast Medullary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.02 ZNF57 ZNF350 ZNF274 TRIM28 LCOR

Sources for Breast Medullary Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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