MCID: BRS015
MIFTS: 34

Breast Medullary Carcinoma

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Breast Medullary Carcinoma

MalaCards integrated aliases for Breast Medullary Carcinoma:

Name: Breast Medullary Carcinoma 12 15
Medullary Breast Carcinoma with Lymphoid Stroma 12
Medullary Carcinoma of Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5605
NCIt 50 C9119
UMLS 73 C0860580

Summaries for Breast Medullary Carcinoma

Disease Ontology : 12 A breast adenocarcinoma that is characterized by a syncitial growth pattern and high grade cytology.

MalaCards based summary : Breast Medullary Carcinoma, also known as medullary breast carcinoma with lymphoid stroma, is related to lymphocytic gastritis and lymphomatoid papulosis. An important gene associated with Breast Medullary Carcinoma is GZMB (Granzyme B), and among its related pathways/superpathways are Pathways in cancer and Glioma. Affiliated tissues include lung, bone and ovary, and related phenotypes are Decreased viability in esophageal squamous lineage and cardiovascular system

Related Diseases for Breast Medullary Carcinoma

Diseases related to Breast Medullary Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 lymphocytic gastritis 10.1 FASLG GZMB
2 lymphomatoid papulosis 10.1 FASLG GZMB
3 choriocarcinoma of the testis 10.1 FASLG GZMB
4 t-cell large granular lymphocyte leukemia 10.1 FASLG GZMB
5 erythema multiforme 10.1 FASLG GZMB
6 acute graft versus host disease 10.1 FASLG GZMB
7 b-cell expansion with nfkb and t-cell anergy 10.1 FASLG GZMB
8 comedo carcinoma 10.1 ERBB2 ESR1
9 tuberculous salpingitis 10.1 BRCA1 ERBB2
10 severe cutaneous adverse reaction 10.0 FASLG GZMB
11 hidradenocarcinoma 10.0 ERBB2 ESR1
12 fallopian tube adenocarcinoma 10.0 BRCA1 ERBB2
13 uterine corpus serous adenocarcinoma 10.0 BRCA1 ERBB2
14 graft-versus-host disease 10.0 FASLG GZMB
15 scirrhous adenocarcinoma 10.0 ERBB2 PGR
16 vestibular gland benign neoplasm 10.0 ESR1 PGR
17 breast apocrine carcinoma 10.0 ERBB2 PGR
18 bartholin's gland adenoma 10.0 ESR1 PGR
19 vulvar syringoma 10.0 ESR1 PGR
20 lung leiomyoma 10.0 ESR1 PGR
21 leiomyoma 10.0 ESR1 PGR
22 myoma 10.0 ESR1 PGR
23 ovarian cancer 1 10.0 BRCA1 ERBB2
24 vulvar benign neoplasm 10.0 ESR1 PGR
25 trigonitis 10.0 ESR1 PGR
26 vulvar leiomyoma 10.0 ESR1 PGR
27 intracystic papillary adenoma 10.0 ERBB2 PGR
28 breast metaplastic carcinoma 10.0 ERBB2 PGR
29 predominantly cortical thymoma 10.0 ESR1 PGR
30 progesterone-receptor negative breast cancer 10.0 ERBB2 PGR
31 alopecia areata 10.0 FASLG GZMB
32 bartholin's gland benign neoplasm 10.0 ESR1 PGR
33 oncocytic breast carcinoma 10.0 ESR1 PGR
34 progesterone resistance 10.0 ESR1 PGR
35 endometrial squamous cell carcinoma 10.0 ESR1 PGR
36 cribriform carcinoma 10.0 ESR1 PGR
37 endometrial mucinous adenocarcinoma 10.0 ESR1 PGR
38 adenoid basal cell carcinoma 10.0 ESR1 PGR
39 peritoneal benign neoplasm 10.0 ESR1 PGR
40 gender identity disorder 10.0 ESR1 PGR
41 deep angioma 10.0 ESR1 PGR
42 diffuse peritoneal leiomyomatosis 10.0 ESR1 PGR
43 leiomyomatosis 10.0 ESR1 PGR
44 uterine body mixed cancer 10.0 ERBB2 PGR
45 female reproductive endometrioid cancer 10.0 ESR1 PGR
46 cervical carcinosarcoma 10.0 ESR1 PGR
47 carcinosarcoma 10.0 ERBB2 PGR
48 estrogen excess 10.0 ESR1 PGR
49 intramuscular hemangioma 10.0 ESR1 PGR
50 mammographic density 9.9 ESR1 PGR

Graphical network of the top 20 diseases related to Breast Medullary Carcinoma:



Diseases related to Breast Medullary Carcinoma

Symptoms & Phenotypes for Breast Medullary Carcinoma

GenomeRNAi Phenotypes related to Breast Medullary Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.02 BRCA1 ERBB2 ESR1 FASLG PGR

MGI Mouse Phenotypes related to Breast Medullary Carcinoma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.89 BRCA1 ERBB2 ESR1 FASLG PGR
2 endocrine/exocrine gland MP:0005379 9.85 BRCA1 ERBB2 ESR1 FASLG PGR
3 integument MP:0010771 9.83 BRCA1 ERBB2 ESR1 FASLG PGR
4 digestive/alimentary MP:0005381 9.78 BRCA1 ERBB2 ESR1 FASLG
5 neoplasm MP:0002006 9.72 BRCA1 ERBB2 ESR1 FASLG PGR
6 limbs/digits/tail MP:0005371 9.71 BRCA1 ERBB2 ESR1 PGR
7 muscle MP:0005369 9.67 BRCA1 ERBB2 ESR1 PGR
8 normal MP:0002873 9.65 BRCA1 ERBB2 ESR1 FASLG PGR
9 reproductive system MP:0005389 9.55 BRCA1 ERBB2 ESR1 FASLG PGR
10 respiratory system MP:0005388 9.26 BRCA1 ERBB2 ESR1 FASLG
11 skeleton MP:0005390 9.02 BRCA1 ERBB2 ESR1 FASLG PGR

Drugs & Therapeutics for Breast Medullary Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Medullary Carcinoma

Genetic Tests for Breast Medullary Carcinoma

Anatomical Context for Breast Medullary Carcinoma

MalaCards organs/tissues related to Breast Medullary Carcinoma:

41
Lung, Bone, Ovary, Prostate, T Cells, Smooth Muscle

Publications for Breast Medullary Carcinoma

Articles related to Breast Medullary Carcinoma:

# Title Authors Year
1
Immunoglobulin repertoire of B lymphocytes infiltrating breast medullary carcinoma. ( 15156099 )
2003
2
A scFv phage display mini library generated from the immunoglobulin repertoire of breast medullary carcinoma infiltrating B lymphocytes. ( 11360824 )
2000
3
Immunoglobulin variable regions usage by B-lymphocytes infiltrating a human breast medullary carcinoma. ( 10065736 )
1999

Variations for Breast Medullary Carcinoma

Cosmic variations for Breast Medullary Carcinoma:

9 (show all 19)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM763 PIK3CA breast,NS,carcinoma,medullary c.1633G>A p.E545K 3:179218303-179218303 13
2 COSM775 PIK3CA breast,NS,carcinoma,medullary c.3140A>G p.H1047R 3:179234297-179234297 13
3 COSM10648 TP53 breast,NS,carcinoma,medullary carcinoma c.524G>A p.R175H 17:7675088-7675088 12
4 COSM44687 TP53 breast,NS,carcinoma,medullary carcinoma c.379T>C p.S127P 17:7675233-7675233 12
5 COSM10758 TP53 breast,NS,carcinoma,medullary carcinoma c.659A>G p.Y220C 17:7674872-7674872 12
6 COSM11286 TP53 breast,NS,carcinoma,medullary carcinoma c.1015G>T p.E339* 17:7670694-7670694 12
7 COSM10667 TP53 breast,NS,carcinoma,medullary carcinoma c.646G>A p.V216M 17:7674885-7674885 12
8 COSM10654 TP53 breast,NS,carcinoma,medullary carcinoma c.637C>T p.R213* 17:7674894-7674894 12
9 COSM10893 TP53 breast,NS,carcinoma,medullary carcinoma c.824G>A p.C275Y 17:7673796-7673796 12
10 COSM11089 TP53 breast,NS,carcinoma,medullary carcinoma c.584T>C p.I195T 17:7674947-7674947 12
11 COSM10662 TP53 breast,NS,carcinoma,medullary carcinoma c.743G>A p.R248Q 17:7674220-7674220 12
12 COSM11148 TP53 breast,NS,carcinoma,medullary carcinoma c.476C>T p.A159V 17:7675136-7675136 12
13 COSM10726 TP53 breast,NS,carcinoma,medullary carcinoma c.856G>A p.E286K 17:7673764-7673764 12
14 COSM10834 TP53 breast,NS,carcinoma,medullary carcinoma c.711G>A p.M237I 17:7674252-7674252 12
15 COSM43947 TP53 breast,NS,carcinoma,medullary carcinoma c.614A>G p.Y205C 17:7674917-7674917 12
16 COSM10646 TP53 breast,NS,carcinoma,medullary carcinoma c.725G>A p.C242Y 17:7674238-7674238 12
17 COSM10728 TP53 breast,NS,carcinoma,medullary carcinoma c.839G>A p.R280K 17:7673781-7673781 12
18 COSM10742 TP53 breast,NS,carcinoma,medullary carcinoma c.578A>G p.H193R 17:7674953-7674953 12
19 COSM10731 TP53 breast,NS,carcinoma,medullary carcinoma c.707A>G p.Y236C 17:7674256-7674256 12

Expression for Breast Medullary Carcinoma

Search GEO for disease gene expression data for Breast Medullary Carcinoma.

Pathways for Breast Medullary Carcinoma

Pathways related to Breast Medullary Carcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1 12.43 ERBB2 ESR1 FASLG
2
Show member pathways
12.37 BRCA1 ERBB2 ESR1
3
Show member pathways
12.29 BRCA1 ESR1 FASLG
4
Show member pathways
12.28 ERBB2 ESR1 FASLG
5
Show member pathways
12.12 BRCA1 ERBB2 ESR1 PGR
6 11.8 ERBB2 ESR1 FASLG
7
Show member pathways
11.68 BRCA1 ESR1 PGR
8 11.31 BRCA1 ERBB2
9
Show member pathways
11.24 FASLG GZMB
10 11.22 BRCA1 ERBB2
11
Show member pathways
11.17 ERBB2 ESR1 PGR
12 11.11 BRCA1 FASLG
13
Show member pathways
11.03 BRCA1 ESR1
14 10.66 BRCA1 ERBB2 FASLG

GO Terms for Breast Medullary Carcinoma

Biological processes related to Breast Medullary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to estrogen GO:0043627 9.16 BRCA1 ESR1
2 steroid hormone mediated signaling pathway GO:0043401 8.96 ESR1 PGR
3 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 8.62 BRCA1 FASLG

Molecular functions related to Breast Medullary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.5 BRCA1 ESR1 PGR
2 ATPase binding GO:0051117 9.4 ESR1 PGR
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.37 ERBB2 ESR1
4 steroid hormone receptor activity GO:0003707 9.26 ESR1 PGR
5 identical protein binding GO:0042802 9.26 BRCA1 ERBB2 ESR1 PGR
6 nuclear receptor activity GO:0004879 9.16 ESR1 PGR
7 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Breast Medullary Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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