MCID: BRS015
MIFTS: 36

Breast Medullary Carcinoma

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Breast Medullary Carcinoma

MalaCards integrated aliases for Breast Medullary Carcinoma:

Name: Breast Medullary Carcinoma 12 15
Medullary Breast Carcinoma with Lymphoid Stroma 12
Medullary Carcinoma of Breast 12
Medullary Breast Carcinoma 17

Classifications:



External Ids:

Disease Ontology 12 DOID:5605
NCIt 50 C9119
UMLS 72 C0860580

Summaries for Breast Medullary Carcinoma

Disease Ontology : 12 A breast adenocarcinoma that is characterized by a syncitial growth pattern and high grade cytology.

MalaCards based summary : Breast Medullary Carcinoma, also known as medullary breast carcinoma with lymphoid stroma, is related to breast fibroadenoma and tubular adenocarcinoma. An important gene associated with Breast Medullary Carcinoma is GZMB (Granzyme B), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Pathways in cancer. Affiliated tissues include breast, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 75 Medullary carcinoma of the breast is a type of breast... more...

Related Diseases for Breast Medullary Carcinoma

Diseases related to Breast Medullary Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 153)
# Related Disease Score Top Affiliating Genes
1 breast fibroadenoma 29.4 PGR ERBB2
2 tubular adenocarcinoma 29.1 PGR ERBB2 CDH1
3 bilateral breast cancer 29.0 PGR ERBB2 BRCA1
4 breast ductal carcinoma 27.8 TP53 PGR ERBB2 CDH1 BRCA1
5 breast disease 27.7 TP53 PGR FASLG ERBB2 BRCA1
6 lymphocytic gastritis 10.5 GZMB FASLG
7 lymphomatoid papulosis 10.4 GZMB FASLG
8 choriocarcinoma of the testis 10.4 GZMB FASLG
9 t-cell large granular lymphocyte leukemia 10.4 GZMB FASLG
10 erythema multiforme 10.4 GZMB FASLG
11 lichen sclerosus 10.4 TP53 GZMB
12 necrotizing sialometaplasia 10.3 TP53 GZMB
13 acute graft versus host disease 10.3 GZMB FASLG
14 listeriosis 10.3 PRF1 CDH1
15 gastric papillary adenocarcinoma 10.3 TP53 ERBB2
16 breast cystic hypersecretory carcinoma 10.3 ERBB2 CDH1
17 pleomorphic adenoma carcinoma 10.3 TP53 ERBB2
18 non-proliferative fibrocystic change of the breast 10.3 TP53 ERBB2
19 breast squamous cell carcinoma 10.2 TP53 ERBB2
20 glioma susceptibility 1 10.2 TP53 ERBB2
21 esophagus adenocarcinoma 10.2 TP53 ERBB2
22 b-cell expansion with nfkb and t-cell anergy 10.2 GZMB FASLG
23 cerebral convexity meningioma 10.2 TP53 CDH1
24 tuberculous salpingitis 10.2 ERBB2 BRCA1
25 hidradenocarcinoma 10.2 TP53 ERBB2
26 keratoacanthoma 10.2 TP53 GZMB
27 granulosa cell tumor of the ovary 10.2 TP53 ERBB2
28 sarcomatoid renal cell carcinoma 10.2 TP53 CDH1
29 fallopian tube adenocarcinoma 10.2 ERBB2 BRCA1
30 brain glioma 10.2 TP53 FASLG
31 epstein-barr virus-associated gastric carcinoma 10.1 FASLG CDH1
32 barrett's adenocarcinoma 10.1 TP53 ERBB2
33 tongue disease 10.1 TP53 CDH1
34 breast cancer 10.1
35 ovary adenocarcinoma 10.1 TP53 ERBB2
36 oropharynx cancer 10.1 TP53 CDH1
37 pharynx cancer 10.1 TP53 CDH1
38 laryngeal disease 10.1 TP53 CDH1
39 bile duct adenocarcinoma 10.1 TP53 CDH1
40 rare tumor 10.0
41 breast apocrine carcinoma 10.0 PGR ERBB2
42 scirrhous adenocarcinoma 10.0 PGR ERBB2
43 mutagen sensitivity 10.0 TP53 BRCA1
44 glassy cell carcinoma of the cervix 10.0 PGR ERBB2
45 intracystic papillary adenoma 10.0 PGR ERBB2
46 breast metaplastic carcinoma 10.0 PGR ERBB2
47 breast scirrhous carcinoma 10.0 PGR ERBB2
48 progesterone-receptor negative breast cancer 10.0 PGR ERBB2
49 esophageal disease 10.0 TP53 ERBB2
50 progesterone-receptor positive breast cancer 10.0 PGR ERBB2

Graphical network of the top 20 diseases related to Breast Medullary Carcinoma:



Diseases related to Breast Medullary Carcinoma

Symptoms & Phenotypes for Breast Medullary Carcinoma

GenomeRNAi Phenotypes related to Breast Medullary Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.61 CDH1
2 Decreased viability GR00221-A-2 9.61 BRCA1
3 Decreased viability GR00221-A-3 9.61 BRCA1
4 Decreased viability GR00301-A 9.61 BRCA1 CDH1 GZMB
5 Decreased viability GR00402-S-2 9.61 BRCA1 CDH1 GZMB
6 Decreased viability in esophageal squamous lineage GR00235-A 9.1 BRCA1 CDH1 ERBB2 FASLG PGR TP53

MGI Mouse Phenotypes related to Breast Medullary Carcinoma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.04 BRCA1 CDH1 ERBB2 FASLG PGR PRF1
2 cellular MP:0005384 10.02 BRCA1 CDH1 ERBB2 FASLG PGR PRF1
3 endocrine/exocrine gland MP:0005379 9.95 BRCA1 CDH1 ERBB2 FASLG PGR PRF1
4 homeostasis/metabolism MP:0005376 9.91 BRCA1 CDH1 ERBB2 FASLG PGR PRF1
5 integument MP:0010771 9.87 BRCA1 CDH1 ERBB2 FASLG PGR PRF1
6 digestive/alimentary MP:0005381 9.85 BRCA1 CDH1 ERBB2 FASLG TP53
7 embryo MP:0005380 9.83 BRCA1 CDH1 ERBB2 PGR TP53
8 mortality/aging MP:0010768 9.8 BRCA1 CDH1 ERBB2 FASLG PGR PRF1
9 neoplasm MP:0002006 9.7 BRCA1 CDH1 ERBB2 FASLG PGR PRF1
10 normal MP:0002873 9.5 BRCA1 CDH1 ERBB2 FASLG PGR PRF1
11 reproductive system MP:0005389 9.17 BRCA1 CDH1 ERBB2 FASLG PGR PRF1

Drugs & Therapeutics for Breast Medullary Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Medullary Carcinoma

Genetic Tests for Breast Medullary Carcinoma

Anatomical Context for Breast Medullary Carcinoma

MalaCards organs/tissues related to Breast Medullary Carcinoma:

41
Breast

Publications for Breast Medullary Carcinoma

Articles related to Breast Medullary Carcinoma:

(show all 13)
# Title Authors PMID Year
1
Cytomorphological Study of Medullary Carcinoma of Breast in Comparison to Infiltrating Ductal Carcinoma. 38
30498288 2018
2
Synchronous bilateral medullary carcinoma of breast: is it metastasis or second primary? 38
22531532 2012
3
Tumor infiltrating lymphocytes differ in invasive micropapillary carcinoma and medullary carcinoma of breast. 38
18469794 2008
4
Medullary carcinoma of breast with a novel germline mutation 1123T >G in exon 11 of BRCA1. 38
16945238 2006
5
Differential amplification and overexpression of HER-2/neu, p53, MIB1, and estrogen receptor/progesterone receptor among medullary carcinoma, atypical medullary carcinoma, and high-grade invasive ductal carcinoma of breast. 38
14567723 2003
6
Lack of HIN-1 methylation defines specific breast tumor subtypes including medullary carcinoma of the breast and BRCA1-linked tumors. 38
14614327 2003
7
Immunoglobulin repertoire of B lymphocytes infiltrating breast medullary carcinoma. 38
15156099 2003
8
A scFv phage display mini library generated from the immunoglobulin repertoire of breast medullary carcinoma infiltrating B lymphocytes. 38
11360824 2000
9
[Medullary carcinoma of the stomach]. 38
11188855 2000
10
Immunoglobulin variable regions usage by B-lymphocytes infiltrating a human breast medullary carcinoma. 38
10065736 1999
11
Class distribution of immunoglobulin-containing plasma cells in the stroma of medullary carcinoma of breast. 38
3013350 1986
12
Medullary carcinoma of breast: an immunohistochemical study of its lymphoid stroma. 38
6268284 1981
13
Inhibition of leukocyte migration by human breast-cancer-associated antigens. 38
62721 1976

Variations for Breast Medullary Carcinoma

Cosmic variations for Breast Medullary Carcinoma:

9 (show all 19)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10648 TP53 breast,NS,carcinoma,medullary carcinoma c.524G>A p.R175H 17:7675088-7675088 21
2 COSM10758 TP53 breast,NS,carcinoma,medullary carcinoma c.659A>G p.Y220C 17:7674872-7674872 21
3 COSM11286 TP53 breast,NS,carcinoma,medullary carcinoma c.1015G>T p.E339* 17:7670694-7670694 21
4 COSM10654 TP53 breast,NS,carcinoma,medullary carcinoma c.637C>T p.R213* 17:7674894-7674894 21
5 COSM10662 TP53 breast,NS,carcinoma,medullary carcinoma c.743G>A p.R248Q 17:7674220-7674220 21
6 COSM11089 TP53 breast,NS,carcinoma,medullary carcinoma c.584T>C p.I195T 17:7674947-7674947 21
7 COSM11148 TP53 breast,NS,carcinoma,medullary carcinoma c.476C>T p.A159V 17:7675136-7675136 21
8 COSM10726 TP53 breast,NS,carcinoma,medullary carcinoma c.856G>A p.E286K 17:7673764-7673764 21
9 COSM10834 TP53 breast,NS,carcinoma,medullary carcinoma c.711G>A p.M237I 17:7674252-7674252 21
10 COSM10646 TP53 breast,NS,carcinoma,medullary carcinoma c.725G>A p.C242Y 17:7674238-7674238 21
11 COSM43947 TP53 breast,NS,carcinoma,medullary carcinoma c.614A>G p.Y205C 17:7674917-7674917 21
12 COSM10728 TP53 breast,NS,carcinoma,medullary carcinoma c.839G>A p.R280K 17:7673781-7673781 21
13 COSM10742 TP53 breast,NS,carcinoma,medullary carcinoma c.578A>G p.H193R 17:7674953-7674953 21
14 COSM10731 TP53 breast,NS,carcinoma,medullary carcinoma c.707A>G p.Y236C 17:7674256-7674256 21
15 COSM44687 TP53 breast,NS,carcinoma,medullary carcinoma c.379T>C p.S127P 17:7675233-7675233 21
16 COSM10667 TP53 breast,NS,carcinoma,medullary carcinoma c.646G>A p.V216M 17:7674885-7674885 21
17 COSM10893 TP53 breast,NS,carcinoma,medullary carcinoma c.824G>A p.C275Y 17:7673796-7673796 21
18 COSM775 PIK3CA breast,NS,carcinoma,medullary c.3140A>G p.H1047R 3:179234297-179234297 21
19 COSM763 PIK3CA breast,NS,carcinoma,medullary c.1633G>A p.E545K 3:179218303-179218303 21

Expression for Breast Medullary Carcinoma

Search GEO for disease gene expression data for Breast Medullary Carcinoma.

Pathways for Breast Medullary Carcinoma

Pathways related to Breast Medullary Carcinoma according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.69 TP53 FASLG ERBB2 BRCA1
2 12.52 TP53 FASLG ERBB2 CDH1
3
Show member pathways
12.48 TP53 PRF1 GZMB FASLG
4
Show member pathways
12.38 PRF1 GZMB FASLG
5
Show member pathways
12.36 TP53 FASLG ERBB2 CDH1
6
Show member pathways
12.35 TP53 ERBB2 CDH1 BRCA1
7 12.3 TP53 ERBB2 BRCA1
8
Show member pathways
12.27 PRF1 GZMB FASLG
9 12.03 TP53 FASLG ERBB2
10
Show member pathways
12.02 TP53 PGR ERBB2 CDH1 BRCA1
11
Show member pathways
12.01 PRF1 GZMB FASLG
12
Show member pathways
11.99 TP53 FASLG BRCA1
13 11.87 TP53 CDH1 BRCA1
14 11.64 TP53 FASLG ERBB2
15 11.41 TP53 ERBB2 CDH1
16 11.35 TP53 FASLG
17
Show member pathways
11.33 PRF1 GZMB
18 11.32 TP53 ERBB2 BRCA1
19 11.3 TP53 BRCA1
20 11.26 TP53 FASLG
21 11.25 TP53 BRCA1
22
Show member pathways
11.22 PRF1 GZMB FASLG
23 11.1 TP53 BRCA1
24 11.08 TP53 BRCA1
25 11.08 ERBB2 CDH1
26 11.04 TP53 FASLG BRCA1
27 11.03 TP53 BRCA1
28 10.8 TP53 BRCA1
29 10.79 TP53 FASLG ERBB2 BRCA1

GO Terms for Breast Medullary Carcinoma

Cellular components related to Breast Medullary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.23 TP53 PRF1 PGR GZMB FASLG ERBB2

Biological processes related to Breast Medullary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.4 FASLG BRCA1
2 positive regulation of cell cycle arrest GO:0071158 9.37 TP53 BRCA1
3 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.32 TP53 GZMB
4 cytolysis GO:0019835 9.26 PRF1 GZMB
5 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.16 TP53 BRCA1
6 apoptotic process GO:0006915 9.02 TP53 PRF1 GZMB FASLG BRCA1
7 cellular response to indole-3-methanol GO:0071681 8.96 CDH1 BRCA1

Molecular functions related to Breast Medullary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.1 TP53 PRF1 PGR ERBB2 CDH1 BRCA1

Sources for Breast Medullary Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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