MCID: BRS015
MIFTS: 35

Breast Medullary Carcinoma

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Breast Medullary Carcinoma

MalaCards integrated aliases for Breast Medullary Carcinoma:

Name: Breast Medullary Carcinoma 12 15
Medullary Breast Carcinoma with Lymphoid Stroma 12
Medullary Carcinoma of Breast 12
Medullary Breast Carcinoma 17

Classifications:



External Ids:

Disease Ontology 12 DOID:5605
NCIt 51 C9119
UMLS 74 C0860580

Summaries for Breast Medullary Carcinoma

Disease Ontology : 12 A breast adenocarcinoma that is characterized by a syncitial growth pattern and high grade cytology.

MalaCards based summary : Breast Medullary Carcinoma, also known as medullary breast carcinoma with lymphoid stroma, is related to breast cancer and lymphocytic gastritis. An important gene associated with Breast Medullary Carcinoma is GZMB (Granzyme B), and among its related pathways/superpathways are Development HGF signaling pathway and Gastric cancer. Affiliated tissues include breast, ovary and t cells, and related phenotypes are cardiovascular system and cellular

Related Diseases for Breast Medullary Carcinoma

Diseases related to Breast Medullary Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 128, show less)
# Related Disease Score Top Affiliating Genes
1 breast cancer 10.5
2 lymphocytic gastritis 10.2 FASLG GZMB
3 lymphomatoid papulosis 10.2 FASLG GZMB
4 choriocarcinoma of the testis 10.2 FASLG GZMB
5 t-cell large granular lymphocyte leukemia 10.2 FASLG GZMB
6 erythema multiforme 10.2 FASLG GZMB
7 acute graft versus host disease 10.1 FASLG GZMB
8 vaginitis 10.1 ESR1 PRF1
9 b-cell expansion with nfkb and t-cell anergy 10.1 FASLG GZMB
10 comedo carcinoma 10.1 ERBB2 ESR1
11 scirrhous adenocarcinoma 10.1 ERBB2 PGR
12 vestibular gland benign neoplasm 10.1 ESR1 PGR
13 breast apocrine carcinoma 10.1 ERBB2 PGR
14 bartholin's gland adenoma 10.1 ESR1 PGR
15 vulvar syringoma 10.1 ESR1 PGR
16 lung leiomyoma 10.1 ESR1 PGR
17 myoma 10.1 ESR1 PGR
18 vulvar benign neoplasm 10.1 ESR1 PGR
19 trigonitis 10.1 ESR1 PGR
20 vulvar leiomyoma 10.1 ESR1 PGR
21 intracystic papillary adenoma 10.1 ERBB2 PGR
22 breast metaplastic carcinoma 10.1 ERBB2 PGR
23 predominantly cortical thymoma 10.1 ESR1 PGR
24 progesterone-receptor negative breast cancer 10.1 ERBB2 PGR
25 bartholin's gland benign neoplasm 10.1 ESR1 PGR
26 oncocytic breast carcinoma 10.1 ESR1 PGR
27 progesterone resistance 10.1 ESR1 PGR
28 endometrial squamous cell carcinoma 10.1 ESR1 PGR
29 cribriform carcinoma 10.1 ESR1 PGR
30 alopecia areata 10.1 FASLG GZMB
31 endometrial mucinous adenocarcinoma 10.1 ESR1 PGR
32 adenoid basal cell carcinoma 10.1 ESR1 PGR
33 hidradenocarcinoma 10.1 ERBB2 ESR1
34 peritoneal benign neoplasm 10.1 ESR1 PGR
35 gender identity disorder 10.1 ESR1 PGR
36 deep angioma 10.1 ESR1 PGR
37 diffuse peritoneal leiomyomatosis 10.0 ESR1 PGR
38 leiomyomatosis 10.0 ESR1 PGR
39 uterine body mixed cancer 10.0 ERBB2 PGR
40 female reproductive endometrioid cancer 10.0 ESR1 PGR
41 cervical carcinosarcoma 10.0 ESR1 PGR
42 carcinosarcoma 10.0 ERBB2 PGR
43 estrogen excess 10.0 ESR1 PGR
44 severe cutaneous adverse reaction 10.0 FASLG GZMB
45 intramuscular hemangioma 10.0 ESR1 PGR
46 mammographic density 10.0 ESR1 PGR
47 cervical clear cell adenocarcinoma 10.0 ESR1 PGR
48 microglandular adenosis 10.0 ERBB2 PGR
49 retinitis pigmentosa 47 10.0 ESR1 PGR
50 retinitis pigmentosa 20 10.0 ESR1 PGR
51 adenosarcoma 10.0 ESR1 PGR
52 endometriosis of ovary 10.0 ESR1 PGR
53 breast secretory carcinoma 10.0 ERBB2 PGR
54 smooth muscle tumor 10.0 ESR1 PGR
55 uterine benign neoplasm 10.0 ESR1 PGR
56 mixed cell type cancer 10.0 ERBB2 PGR
57 endometritis 10.0 ESR1 PGR
58 prostatic hypertrophy 10.0 ESR1 PGR
59 reproductive organ benign neoplasm 10.0 ESR1 PGR
60 papillary adenocarcinoma 10.0 ERBB2 PGR
61 juvenile nasopharyngeal angiofibroma 10.0 ESR1 PGR
62 tuberculous salpingitis 10.0 BRCA1 ERBB2
63 angiomyolipoma 10.0 ESR1 PGR
64 fallopian tube adenocarcinoma 9.9 BRCA1 ERBB2
65 uterine corpus serous adenocarcinoma 9.9 BRCA1 ERBB2
66 gynecomastia 9.9 ESR1 PGR
67 leiomyoma, uterine 9.9 ESR1 PGR
68 adenomyosis 9.9 ESR1 PGR
69 graft-versus-host disease 9.9 FASLG GZMB
70 serous cystadenocarcinoma 9.9 ERBB2 PGR
71 nosophobia 9.9 BRCA1 PGR
72 cancerophobia 9.9 BRCA1 PGR
73 cystadenocarcinoma 9.9 ERBB2 PGR
74 papillary serous adenocarcinoma 9.9 BRCA1 PGR
75 malignant fibroxanthoma 9.9
76 histiocytoma 9.9
77 fibrous histiocytoma 9.9
78 undifferentiated pleomorphic sarcoma 9.9
79 ovarian cancer 1 9.8 BRCA1 ERBB2
80 ovarian serous cystadenocarcinoma 9.8 ERBB2 PGR
81 dysgerminoma of ovary 9.8 BRCA1 PGR
82 glassy cell carcinoma of the cervix 9.8 ERBB2 ESR1 PGR
83 breast scirrhous carcinoma 9.8 ERBB2 ESR1 PGR
84 progesterone-receptor positive breast cancer 9.8 ERBB2 ESR1 PGR
85 apocrine adenocarcinoma 9.8 ERBB2 ESR1 PGR
86 breast adenoid cystic carcinoma 9.8 ERBB2 ESR1 PGR
87 inflammatory breast carcinoma 9.8 ERBB2 ESR1 PGR
88 luminal breast carcinoma 9.8 ERBB2 ESR1 PGR
89 lymphangioleiomyomatosis 9.8 ESR1 PGR
90 breast benign neoplasm 9.8 ERBB2 ESR1 PGR
91 thoracic benign neoplasm 9.8 ERBB2 ESR1 PGR
92 lipid-rich carcinoma 9.8 ERBB2 ESR1 PGR
93 mammary paget's disease 9.8 ERBB2 ESR1 PGR
94 tubular adenocarcinoma 9.8 ERBB2 ESR1 PGR
95 breast fibroadenoma 9.8 ERBB2 ESR1 PGR
96 cervical adenocarcinoma 9.8 ERBB2 ESR1 PGR
97 estrogen-receptor positive breast cancer 9.8 ERBB2 ESR1 PGR
98 sweat gland cancer 9.8 ERBB2 ESR1 PGR
99 uterine anomalies 9.8 ERBB2 ESR1 PGR
100 endometrial adenocarcinoma 9.8 ERBB2 ESR1 PGR
101 wilms tumor 1 9.7 ERBB2 ESR1 PGR
102 lobular neoplasia 9.7 BRCA1 ERBB2 ESR1
103 gonadal disease 9.7 BRCA1 ERBB2 ESR1
104 endocrine gland cancer 9.7 BRCA1 ERBB2 ESR1
105 synchronous bilateral breast carcinoma 9.6 BRCA1 ESR1 PGR
106 glycogen-rich clear cell breast carcinoma 9.6 BRCA1 ESR1 PGR
107 papillary carcinoma 9.6 ERBB2 PGR
108 bilateral breast cancer 9.6 BRCA1 ERBB2 PGR
109 primary peritoneal carcinoma 9.6 BRCA1 ERBB2 PGR
110 ovarian disease 9.6 BRCA1 ESR1 PGR
111 uterine corpus cancer 9.3 BRCA1 ERBB2 ESR1 PGR
112 pre-malignant neoplasm 9.3 BRCA1 ERBB2 ESR1 PGR
113 fallopian tube carcinoma 9.3 BRCA1 ERBB2 ESR1 PGR
114 in situ carcinoma 9.3 BRCA1 ERBB2 ESR1 PGR
115 estrogen-receptor negative breast cancer 9.3 BRCA1 ERBB2 ESR1 PGR
116 breast carcinoma in situ 9.3 BRCA1 ERBB2 ESR1 PGR
117 malignant ovarian surface epithelial-stromal neoplasm 9.3 BRCA1 ERBB2 ESR1 PGR
118 ovary epithelial cancer 9.3 BRCA1 ERBB2 ESR1 PGR
119 female breast cancer 9.3 BRCA1 ERBB2 ESR1 PGR
120 sporadic breast cancer 9.3 BRCA1 ERBB2 ESR1 PGR
121 ductal carcinoma in situ 9.3 BRCA1 ERBB2 ESR1 PGR
122 female reproductive system disease 9.3 BRCA1 ERBB2 ESR1 PGR
123 reproductive system disease 9.3 BRCA1 ERBB2 ESR1 PGR
124 breast ductal carcinoma 9.3 BRCA1 ERBB2 ESR1 PGR
125 adamantinoma of long bones 9.3 BRCA1 ERBB2 ESR1 PGR
126 endometrial cancer 9.3 BRCA1 ERBB2 ESR1 PGR
127 breast disease 9.1 BRCA1 ERBB2 ESR1 FASLG PGR
128 ovarian cancer 9.0 BRCA1 ERBB2 ESR1 FASLG PGR

Graphical network of the top 20 diseases related to Breast Medullary Carcinoma:



Diseases related to Breast Medullary Carcinoma

Symptoms & Phenotypes for Breast Medullary Carcinoma

MGI Mouse Phenotypes related to Breast Medullary Carcinoma:

47 (showing 9, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.93 BRCA1 ERBB2 ESR1 FASLG PGR PRF1
2 cellular MP:0005384 9.91 BRCA1 ERBB2 ESR1 FASLG PGR PRF1
3 endocrine/exocrine gland MP:0005379 9.88 BRCA1 ERBB2 ESR1 FASLG PGR PRF1
4 integument MP:0010771 9.85 BRCA1 ERBB2 ESR1 FASLG PGR PRF1
5 neoplasm MP:0002006 9.73 BRCA1 ERBB2 ESR1 FASLG PGR PRF1
6 normal MP:0002873 9.63 BRCA1 ERBB2 ESR1 FASLG PGR PRF1
7 limbs/digits/tail MP:0005371 9.62 BRCA1 ERBB2 ESR1 PGR
8 reproductive system MP:0005389 9.43 BRCA1 ERBB2 ESR1 FASLG PGR PRF1
9 skeleton MP:0005390 9.02 BRCA1 ERBB2 ESR1 FASLG PGR

Drugs & Therapeutics for Breast Medullary Carcinoma

Interventional clinical trials:

(showing 1, show less)
# Name Status NCT ID Phase Drugs
1 Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer Recruiting NCT03414970 Phase 3

Search NIH Clinical Center for Breast Medullary Carcinoma

Genetic Tests for Breast Medullary Carcinoma

Anatomical Context for Breast Medullary Carcinoma

MalaCards organs/tissues related to Breast Medullary Carcinoma:

42
Breast, Ovary, T Cells, Lung, Bone, Prostate, Smooth Muscle

Publications for Breast Medullary Carcinoma

Articles related to Breast Medullary Carcinoma:

(showing 3, show less)
# Title Authors Year
1
Immunoglobulin repertoire of B lymphocytes infiltrating breast medullary carcinoma. ( 15156099 )
2003
2
A scFv phage display mini library generated from the immunoglobulin repertoire of breast medullary carcinoma infiltrating B lymphocytes. ( 11360824 )
2000
3
Immunoglobulin variable regions usage by B-lymphocytes infiltrating a human breast medullary carcinoma. ( 10065736 )
1999

Variations for Breast Medullary Carcinoma

Cosmic variations for Breast Medullary Carcinoma:

9 (showing 19, show less)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10648 TP53 breast,NS,carcinoma,medullary carcinoma c.524G>A p.R175H 17:7675088-7675088 0
2 COSM10758 TP53 breast,NS,carcinoma,medullary carcinoma c.659A>G p.Y220C 17:7674872-7674872 0
3 COSM11286 TP53 breast,NS,carcinoma,medullary carcinoma c.1015G>T p.E339* 17:7670694-7670694 0
4 COSM10654 TP53 breast,NS,carcinoma,medullary carcinoma c.637C>T p.R213* 17:7674894-7674894 0
5 COSM10662 TP53 breast,NS,carcinoma,medullary carcinoma c.743G>A p.R248Q 17:7674220-7674220 0
6 COSM11089 TP53 breast,NS,carcinoma,medullary carcinoma c.584T>C p.I195T 17:7674947-7674947 0
7 COSM11148 TP53 breast,NS,carcinoma,medullary carcinoma c.476C>T p.A159V 17:7675136-7675136 0
8 COSM10726 TP53 breast,NS,carcinoma,medullary carcinoma c.856G>A p.E286K 17:7673764-7673764 0
9 COSM10834 TP53 breast,NS,carcinoma,medullary carcinoma c.711G>A p.M237I 17:7674252-7674252 0
10 COSM10646 TP53 breast,NS,carcinoma,medullary carcinoma c.725G>A p.C242Y 17:7674238-7674238 0
11 COSM43947 TP53 breast,NS,carcinoma,medullary carcinoma c.614A>G p.Y205C 17:7674917-7674917 0
12 COSM10728 TP53 breast,NS,carcinoma,medullary carcinoma c.839G>A p.R280K 17:7673781-7673781 0
13 COSM10742 TP53 breast,NS,carcinoma,medullary carcinoma c.578A>G p.H193R 17:7674953-7674953 0
14 COSM10731 TP53 breast,NS,carcinoma,medullary carcinoma c.707A>G p.Y236C 17:7674256-7674256 0
15 COSM44687 TP53 breast,NS,carcinoma,medullary carcinoma c.379T>C p.S127P 17:7675233-7675233 0
16 COSM10667 TP53 breast,NS,carcinoma,medullary carcinoma c.646G>A p.V216M 17:7674885-7674885 0
17 COSM10893 TP53 breast,NS,carcinoma,medullary carcinoma c.824G>A p.C275Y 17:7673796-7673796 0
18 COSM775 PIK3CA breast,NS,carcinoma,medullary c.3140A>G p.H1047R 3:179234297-179234297 0
19 COSM763 PIK3CA breast,NS,carcinoma,medullary c.1633G>A p.E545K 3:179218303-179218303 0

Expression for Breast Medullary Carcinoma

Search GEO for disease gene expression data for Breast Medullary Carcinoma.

Pathways for Breast Medullary Carcinoma

Pathways related to Breast Medullary Carcinoma according to GeneCards Suite gene sharing:

(showing 16, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.36 ERBB2 ESR1 FASLG
2
Show member pathways
12.22 BRCA1 ERBB2 ESR1 PGR
3
Show member pathways
12.11 FASLG GZMB PRF1
4
Show member pathways
12.07 FASLG GZMB PRF1
5 11.85 ERBB2 ESR1 FASLG
6
Show member pathways
11.84 FASLG GZMB PRF1
7
Show member pathways
11.74 BRCA1 ESR1 PGR
8
Show member pathways
11.37 FASLG PRF1
9
Show member pathways
11.37 ERBB2 ESR1 PGR
10 11.36 BRCA1 ERBB2
11 11.31 BRCA1 ERBB2
12 11.22 BRCA1 FASLG
13
Show member pathways
11.18 GZMB PRF1
14
Show member pathways
11.14 BRCA1 ESR1
15 11 BRCA1 ERBB2 FASLG
16
Show member pathways
10.58 FASLG GZMB PRF1

GO Terms for Breast Medullary Carcinoma

Biological processes related to Breast Medullary Carcinoma according to GeneCards Suite gene sharing:

(showing 5, show less)
# Name GO ID Score Top Affiliating Genes
1 response to estrogen GO:0043627 9.32 BRCA1 ESR1
2 steroid hormone mediated signaling pathway GO:0043401 9.26 ESR1 PGR
3 apoptotic process GO:0006915 9.26 BRCA1 FASLG GZMB PRF1
4 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.16 BRCA1 FASLG
5 cytolysis GO:0019835 8.62 GZMB PRF1

Molecular functions related to Breast Medullary Carcinoma according to GeneCards Suite gene sharing:

(showing 5, show less)
# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.5 BRCA1 ESR1 PGR
2 steroid hormone receptor activity GO:0003707 9.26 ESR1 PGR
3 nuclear receptor activity GO:0004879 9.16 ESR1 PGR
4 identical protein binding GO:0042802 9.02 BRCA1 ERBB2 ESR1 PGR PRF1
5 steroid binding GO:0005496 8.96 ESR1 PGR

Sources for Breast Medullary Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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