MCID: BRS056
MIFTS: 40

Breast Metaplastic Carcinoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Breast Metaplastic Carcinoma

Summaries for Breast Metaplastic Carcinoma

NIH Rare Diseases : 54 Metaplastic carcinoma of the breast is a rare form of breast cancer. The tumorcells differ in type from that of the typical ductal or lobular breast cancers. The cells look like skin cells or cells that make bone. Some women experience no early signs or symptoms, while others experience general symptoms of breast cancers, such as new breast lumps. Treatment of metaplastic carcinoma of the breast is similar to that of invasive ductal cancer.

MalaCards based summary : Breast Metaplastic Carcinoma, also known as metaplastic carcinoma of the breast, is related to breast squamous cell carcinoma and carcinosarcoma, and has symptoms including pain An important gene associated with Breast Metaplastic Carcinoma is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2), and among its related pathways/superpathways is Signaling by ERBB4. The drugs nivolumab and Ipilimumab have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and bone, and related phenotypes are behavior/neurological and craniofacial

Disease Ontology : 12 A breast carcinoma that represents a mixed group of malignant neoplasms characterized by the histologic presence of two or more cellular types.

Related Diseases for Breast Metaplastic Carcinoma

Diseases related to Breast Metaplastic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 breast squamous cell carcinoma 32.3 ERBB2 KRT5
2 carcinosarcoma 30.3 ERBB2 PGR
3 spindle cell carcinoma 30.3 KRT5 PGR
4 adenoid cystic carcinoma 29.8 ERBB2 KRT5 PGR
5 breast mucoepidermoid carcinoma 11.3
6 adenosquamous breast carcinoma 11.3
7 mixed epithelial/mesenchymal metaplastic breast carcinoma 11.3
8 breast cystic hypersecretory carcinoma 10.2 ERBB2 KRT5
9 breast cancer 10.2
10 fibromatosis 10.2
11 sulfite oxidase deficiency due to molybdenum cofactor deficiency 10.2
12 squamous cell carcinoma 10.2
13 scirrhous adenocarcinoma 10.2 ERBB2 PGR
14 breast apocrine carcinoma 10.2 ERBB2 PGR
15 glassy cell carcinoma of the cervix 10.2 ERBB2 PGR
16 intracystic papillary adenoma 10.2 ERBB2 PGR
17 progesterone-receptor negative breast cancer 10.2 ERBB2 PGR
18 breast medullary carcinoma 10.2 ERBB2 PGR
19 hidradenocarcinoma 10.2 ERBB2 KRT5
20 breast scirrhous carcinoma 10.2 ERBB2 PGR
21 progesterone-receptor positive breast cancer 10.2 ERBB2 PGR
22 uterine body mixed cancer 10.2 ERBB2 PGR
23 tonsil cancer 10.2 ERBB2 KRT5
24 breast adenoid cystic carcinoma 10.2 ERBB2 PGR
25 microglandular adenosis 10.2 ERBB2 PGR
26 inflammatory breast carcinoma 10.1 ERBB2 PGR
27 luminal breast carcinoma 10.1 ERBB2 PGR
28 uterine corpus cancer 10.1 ERBB2 PGR
29 mixed cell type cancer 10.1 ERBB2 PGR
30 mammary paget's disease 10.1 ERBB2 PGR
31 bilateral breast cancer 10.1 ERBB2 PGR
32 cervical clear cell adenocarcinoma 10.1 KRT5 PGR
33 primary peritoneal carcinoma 10.1 ERBB2 PGR
34 tubular adenocarcinoma 10.1 ERBB2 PGR
35 sarcoma 10.1
36 sweat gland disease 10.1 KRT5 PGR
37 fallopian tube carcinoma 10.1 ERBB2 PGR
38 papillary adenocarcinoma 10.1 ERBB2 PGR
39 estrogen-receptor negative breast cancer 10.1 ERBB2 PGR
40 breast fibroadenoma 10.1 ERBB2 PGR
41 malignant ovarian surface epithelial-stromal neoplasm 10.1 ERBB2 PGR
42 ovary epithelial cancer 10.1 ERBB2 PGR
43 female breast cancer 10.1 ERBB2 PGR
44 serous cystadenocarcinoma 10.1 ERBB2 PGR
45 cystadenocarcinoma 10.1 ERBB2 PGR
46 cervical adenocarcinoma 10.1 ERBB2 PGR
47 estrogen-receptor positive breast cancer 10.1 ERBB2 PGR
48 uterine anomalies 10.0 ERBB2 PGR
49 sporadic breast cancer 10.0 ERBB2 PGR
50 ovarian serous cystadenocarcinoma 10.0 ERBB2 PGR

Graphical network of the top 20 diseases related to Breast Metaplastic Carcinoma:



Diseases related to Breast Metaplastic Carcinoma

Symptoms & Phenotypes for Breast Metaplastic Carcinoma

UMLS symptoms related to Breast Metaplastic Carcinoma:


pain

MGI Mouse Phenotypes related to Breast Metaplastic Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.35 ERBB2 FEZF1 FEZF2 KRT5 PGR
2 craniofacial MP:0005382 8.92 ERBB2 FEZF1 FEZF2 KRT5

Drugs & Therapeutics for Breast Metaplastic Carcinoma

Drugs for Breast Metaplastic Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2
Ipilimumab Approved Phase 2 477202-00-9
3 Immunoglobulins Phase 2
4 Antibodies, Monoclonal Phase 2
5 Antineoplastic Agents, Immunological Phase 2
6 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2

Search NIH Clinical Center for Breast Metaplastic Carcinoma

Genetic Tests for Breast Metaplastic Carcinoma

Anatomical Context for Breast Metaplastic Carcinoma

MalaCards organs/tissues related to Breast Metaplastic Carcinoma:

42
Breast, Skin, Bone, Lymph Node

Publications for Breast Metaplastic Carcinoma

Articles related to Breast Metaplastic Carcinoma:

(show top 50) (show all 85)
# Title Authors Year
1
Metaplastic carcinoma of the breast with mesenchymal differentiation (carcinosarcoma). A unique presentation of an aggressive malignancy and literature review. ( 29504519 )
2018
2
Rare variant of metaplastic carcinoma of the breast: a case report and review of the literature. ( 29463294 )
2018
3
Imaging Findings of Metaplastic Carcinoma of the Breast with Pathologic Correlation. ( 30039058 )
2018
4
Metaplastic carcinoma of the breast: A diagnostic challenge on fine needle aspiration cytology. ( 30043535 )
2018
5
PI3K inhibitor provides durable response in metastatic metaplastic carcinoma of the breast: A hidden gem in the BELLE-4 study. ( 30577988 )
2018
6
Metaplastic Carcinoma of the Breast Is More Aggressive Than Triple-negative Breast Cancer: A Study From a Single Institution and Review of Literature. ( 28529029 )
2017
7
Clinicopathological characteristics and prognosis of metaplastic carcinoma of the breast. ( 28781640 )
2017
8
Metaplastic carcinoma of the breast with widespread telangiectatic form of osteosarcomatous differentiation. ( 26645580 )
2016
9
Pregnancy-like hyperplasia and cystic hypersecretory changes adjacent to metaplastic carcinoma of the breast. ( 26960660 )
2016
10
Metaplastic carcinoma of the breast: Imaging and pathological features. ( 27895758 )
2016
11
A case of matrix-producing metaplastic carcinoma of the breast exhibiting similarities to pleomorphic adenoma on fine-needle aspiration cytology. ( 26823890 )
2015
12
Prognostic factors in metaplastic carcinoma of the breast: a multi-institutional study. ( 25422911 )
2015
13
Cancer stem cell and epithelial-mesenchymal transition markers predict worse outcome in metaplastic carcinoma of the breast. ( 25677743 )
2015
14
Metaplastic carcinoma of the breast. ( 26030252 )
2015
15
Aggressive Metaplastic Carcinoma of the Breast with Osteoclastic Giant Cells. ( 26629304 )
2015
16
Fibromatosis-like metaplastic carcinoma of the breast has a claudin-low immunohistochemical phenotype. ( 24903673 )
2014
17
Metaplastic carcinoma of the breast: Treatment, results and prognostic factors based on international literature. ( 24195912 )
2014
18
Metaplastic carcinoma of the breast with chondroid differentiation (matrix-producing carcinoma): study of the diagnostic cost-effectiveness of fine-needle aspiration biopsy and needle core biopsy. ( 24246799 )
2014
19
Metaplastic carcinoma of the breast with rhabdo-myosarcomatous element. ( 25006301 )
2014
20
Metaplastic carcinoma of the breast: an immunohistochemical study. ( 25030022 )
2014
21
Metaplastic carcinoma of the breast: A case report with review of literature. ( 25494151 )
2014
22
Metaplastic carcinoma of the breast: A rare carcinoma with chondroid metaplasia. ( 25931882 )
2014
23
Metaplastic carcinoma of the breast with transformation from adenosquamous carcinoma to osteosarcomatoid and spindle cell morphology. ( 24137400 )
2013
24
The prognostic significance of metaplastic carcinoma of the breast (MCB)--a case controlled comparison study with infiltrating ductal carcinoma. ( 23787124 )
2013
25
Breast metaplastic carcinoma with unusual small cell component. ( 23507669 )
2012
26
Low-grade fibromatosis-like spindle cell metaplastic carcinoma of the breast: a case report and literature review. ( 22444721 )
2012
27
Review of metaplastic carcinoma of the breast: imaging findings and pathologic features. ( 22616038 )
2012
28
Metaplastic carcinoma of the breast with dominant squamous and sebaceous differentiation in the primary tumor and osteochondroid metaplasia in a distant metastasis: report of a case with review of sebaceous differentiation in breast tumors. ( 21865268 )
2012
29
Metaplastic carcinoma of the breast: multimodality imaging and histopathologic assessment. ( 22090465 )
2012
30
Twelve cases of metaplastic carcinoma of the breast: experience of the university hospital of Fez Morocco. ( 20454905 )
2011
31
Challenges to diagnose metaplastic carcinoma of the breast through cytologic methods: an eight-case series. ( 21244696 )
2011
32
Metaplastic carcinoma of the breast with neuroectodermal stromal component. ( 21437182 )
2011
33
Responses to liposomal Doxorubicin, bevacizumab, and temsirolimus in metaplastic carcinoma of the breast: biologic rationale and implications for stem-cell research in breast cancer. ( 21482991 )
2011
34
Metaplastic carcinoma of the breast: cytological diagnosis and diagnostic pitfalls. ( 21791899 )
2011
35
Lack of efficacy to systemic chemotherapy for treatment of metaplastic carcinoma of the breast in the modern era. ( 21792625 )
2011
36
A case of metaplastic carcinoma of the breast. ( 21803877 )
2011
37
Metaplastic carcinoma of the breast with high grade spindle cell component with osteoid formation--a rare case report. ( 21954743 )
2011
38
Metaplastic carcinoma of the breast: clinicopathological features and immunohistochemical analysis. ( 22331717 )
2011
39
Keloid type of fibromatosis-like metaplastic carcinoma of the breast with transformation into biphasic tumour in recurrences and lymph node metastases. ( 20716174 )
2010
40
Metaplastic carcinoma of the breast. ( 20236684 )
2010
41
Metaplastic carcinoma of the breast-a rare neoplasm with transitional cell differentiation: an exceptional feature. ( 20551558 )
2010
42
Fibromatosislike metaplastic carcinoma of the breast as a diagnostic pitfall for fine needle aspiration cytology: a case report. ( 20968161 )
2010
43
A case of metaplastic carcinoma of the breast responsive to chemotherapy with Ifosfamide and Etoposide: improved antitumor response by targeting sarcomatous features. ( 21070449 )
2010
44
Mixed metaplastic carcinoma of the breast associated with pregnancy: Diagnostic dilemmas in fine-needle aspiration cytology. ( 19459158 )
2009
45
Report of a metaplastic carcinoma of the breast with multi-directional differentiation: an adenoid cystic carcinoma, a spindle cell carcinoma and melanoma. ( 18283489 )
2008
46
Metaplastic carcinoma of the breast (carcinosarcoma variant): a case report. ( 17883089 )
2007
47
Fine-needle aspiration cytology of metaplastic carcinoma of the breast. ( 16798932 )
2007
48
Metaplastic carcinoma of the breast, an unusual disease with worse prognosis: the experience of the European Institute of Oncology and review of the literature. ( 17009109 )
2007
49
Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition. ( 17603561 )
2007
50
Metaplastic carcinoma of the breast: a retrospective review. ( 16246496 )
2006

Variations for Breast Metaplastic Carcinoma

Cosmic variations for Breast Metaplastic Carcinoma:

9 (show top 50) (show all 54)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6956502 ZFHX3 breast,NS,carcinoma,metaplastic carcinoma c.4282G>A p.A1428T 16:72798400-72798400 0
2 COSM10648 TP53 breast,NS,carcinoma,metaplastic carcinoma c.524G>A p.R175H 17:7675088-7675088 0
3 COSM10726 TP53 breast,NS,carcinoma,metaplastic carcinoma c.856G>A p.E286K 17:7673764-7673764 0
4 COSM10645 TP53 breast,NS,carcinoma,metaplastic carcinoma c.527G>T p.C176F 17:7675085-7675085 0
5 COSM44268 TP53 breast,NS,carcinoma,metaplastic carcinoma c.559+1G>T p.? 17:7675052-7675052 0
6 COSM10662 TP53 breast,NS,carcinoma,metaplastic carcinoma c.743G>A p.R248Q 17:7674220-7674220 0
7 COSM11582 TP53 breast,NS,carcinoma,metaplastic carcinoma c.395A>G p.K132R 17:7675217-7675217 0
8 COSM6918851 RBM10 breast,NS,carcinoma,metaplastic carcinoma c.688C>G p.R230G 23:47179127-47179127 0
9 COSM5991648 RB1 breast,NS,carcinoma,metaplastic carcinoma c.1421+1G>C p.? 13:48380085-48380085 0
10 COSM5991640 RB1 breast,NS,carcinoma,metaplastic carcinoma c.607+2T>A p.? 13:48349025-48349025 0
11 COSM1968237 PTEN breast,NS,carcinoma,metaplastic carcinoma c.402G>T p.M134I 10:87933161-87933161 0
12 COSM775 PIK3CA breast,NS,carcinoma,metaplastic carcinoma c.3140A>G p.H1047R 3:179234297-179234297 0
13 COSM763 PIK3CA breast,NS,carcinoma,metaplastic carcinoma c.1633G>A p.E545K 3:179218303-179218303 0
14 COSM6966234 NF1 breast,NS,carcinoma,metaplastic carcinoma c.634G>C p.V212L 17:31181469-31181469 0
15 COSM6916545 NF1 breast,NS,carcinoma,metaplastic carcinoma c.3082G>T p.D1028Y 17:31230351-31230351 0
16 COSM6922156 IRS1 breast,NS,carcinoma,metaplastic carcinoma c.3564C>A p.F1188L 2:226795175-226795175 0
17 COSM489 HRAS breast,NS,carcinoma,metaplastic carcinoma c.38G>T p.G13V 11:534285-534285 0
18 COSM6918850 FLT4 breast,NS,carcinoma,metaplastic carcinoma c.2890G>T p.V964L 5:180618881-180618881 0
19 COSM6918844 FBXW7 breast,NS,carcinoma,metaplastic carcinoma c.1418+2T>G p.? 4:152328206-152328206 0
20 COSM5666 CTNNB1 breast,NS,carcinoma,metaplastic carcinoma c.110C>A p.S37Y 3:41224622-41224622 0
21 COSM5677 CTNNB1 breast,NS,carcinoma,metaplastic carcinoma c.98C>G p.S33C 3:41224610-41224610 0
22 COSM5732 CTNNB1 breast,NS,carcinoma,metaplastic carcinoma c.125C>G p.T42R 3:41224637-41224637 0
23 COSM27311 CTNNB1 breast,NS,carcinoma,metaplastic carcinoma c.97T>A p.S33T 3:41224609-41224609 0
24 COSM12475 CDKN2A breast,NS,carcinoma,metaplastic carcinoma c.238C>T p.R80* 9:21971121-21971121 0
25 COSM12736 CDKN2A breast,NS,carcinoma,metaplastic carcinoma c.104G>T p.G35V 9:21974724-21974724 0
26 COSM19476 APC breast,NS,carcinoma,metaplastic carcinoma c.4616C>G p.S1539* 5:112840210-112840210 0
27 COSM18942 APC breast,NS,carcinoma,metaplastic carcinoma c.3928A>T p.K1310* 5:112839522-112839522 0
28 COSM6985595 breast,NS,carcinoma,metaplastic carcinoma c.104G>T p.G35V 9:21974724-21974724 0
29 COSM308310 breast,NS,carcinoma,metaplastic carcinoma c.395A>G p.K132R 17:7675217-7675217 0
30 COSM308311 breast,NS,carcinoma,metaplastic carcinoma c.395A>G p.K132R 17:7675217-7675217 0
31 COSM3388223 breast,NS,carcinoma,metaplastic carcinoma c.395A>G p.K132R 17:7675217-7675217 0
32 COSM99021 breast,NS,carcinoma,metaplastic carcinoma c.464G>A p.R155Q 17:7674220-7674220 0
33 COSM94986 breast,NS,carcinoma,metaplastic carcinoma c.3140A>G p.H1047R 3:179234297-179234297 0
34 COSM99020 breast,NS,carcinoma,metaplastic carcinoma c.743G>A p.R248Q 17:7674220-7674220 0
35 COSM6985594 breast,NS,carcinoma,metaplastic carcinoma c.104G>T p.G35V 9:21974724-21974724 0
36 COSM99023 breast,NS,carcinoma,metaplastic carcinoma c.128G>A p.R43H 17:7675088-7675088 0
37 COSM99602 breast,NS,carcinoma,metaplastic carcinoma c.743G>A p.R248Q 17:7674220-7674220 0
38 COSM1640830 breast,NS,carcinoma,metaplastic carcinoma c.743G>A p.R248Q 17:7674220-7674220 0
39 COSM6918843 breast,NS,carcinoma,metaplastic carcinoma c.1418+2T>G p.? 4:152328206-152328206 0
40 COSM99024 breast,NS,carcinoma,metaplastic carcinoma c.245G>A p.R82H 17:7675088-7675088 0
41 COSM6918849 breast,NS,carcinoma,metaplastic carcinoma c.2890G>T p.V964L 5:180618881-180618881 0
42 COSM6966233 breast,NS,carcinoma,metaplastic carcinoma c.634G>C p.V212L 17:31181469-31181469 0
43 COSM6918845 breast,NS,carcinoma,metaplastic carcinoma c.1178+2T>G p.? 4:152328206-152328206 0
44 COSM1646844 breast,NS,carcinoma,metaplastic carcinoma c.395A>G p.K132R 17:7675217-7675217 0
45 COSM6918847 breast,NS,carcinoma,metaplastic carcinoma c.890+2T>G p.? 4:152328206-152328206 0
46 COSM6918848 breast,NS,carcinoma,metaplastic carcinoma c.701+2T>G p.? 4:152328206-152328206 0
47 COSM99914 breast,NS,carcinoma,metaplastic carcinoma c.524G>A p.R175H 17:7675088-7675088 0
48 COSM6918846 breast,NS,carcinoma,metaplastic carcinoma c.1064+2T>G p.? 4:152328206-152328206 0
49 COSM308312 breast,NS,carcinoma,metaplastic carcinoma c.116A>G p.K39R 17:7675217-7675217 0
50 COSM1640851 breast,NS,carcinoma,metaplastic carcinoma c.524G>A p.R175H 17:7675088-7675088 0

Expression for Breast Metaplastic Carcinoma

Search GEO for disease gene expression data for Breast Metaplastic Carcinoma.

Pathways for Breast Metaplastic Carcinoma

Pathways related to Breast Metaplastic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.66 ERBB2 PGR

GO Terms for Breast Metaplastic Carcinoma

Biological processes related to Breast Metaplastic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.58 ERBB2 FEZF1 FEZF2
2 positive regulation of neuron differentiation GO:0045666 9.43 FEZF1 FEZF2
3 cell differentiation GO:0030154 9.43 FEZF1 FEZF2 SEPT6
4 forebrain development GO:0030900 9.37 FEZF1 FEZF2
5 regulation of neurogenesis GO:0050767 9.32 FEZF1 FEZF2
6 telencephalon development GO:0021537 9.16 FEZF1 FEZF2
7 cell dedifferentiation GO:0043697 8.96 FEZF1 FEZF2
8 forebrain anterior/posterior pattern specification GO:0021797 8.62 FEZF1 FEZF2

Molecular functions related to Breast Metaplastic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.13 FEZF1 FEZF2 PGR
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 8.8 FEZF1 FEZF2 PGR

Sources for Breast Metaplastic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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