MCID: BRS056
MIFTS: 40

Breast Metaplastic Carcinoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Breast Metaplastic Carcinoma

Summaries for Breast Metaplastic Carcinoma

NIH Rare Diseases : 53 Metaplastic carcinoma of the breast is a rare form of breast cancer. The tumorcells differ in type from that of the typical ductal or lobular breast cancers. The cells look like skin cells or cells that make bone. Some women experience no early signs or symptoms, while others experience general symptoms of breast cancers, such as new breast lumps. Treatment of metaplastic carcinoma of the breast is similar to that of invasive ductal cancer.

MalaCards based summary : Breast Metaplastic Carcinoma, also known as metaplastic carcinoma of the breast, is related to breast squamous cell carcinoma and spindle cell carcinoma, and has symptoms including pain An important gene associated with Breast Metaplastic Carcinoma is KRT5 (Keratin 5), and among its related pathways/superpathways is Signaling by ERBB4. Affiliated tissues include breast, skin and bone, and related phenotypes are behavior/neurological and craniofacial

Disease Ontology : 12 A breast carcinoma that represents a mixed group of malignant neoplasms characterized by the histologic presence of two or more cellular types.

Related Diseases for Breast Metaplastic Carcinoma

Diseases related to Breast Metaplastic Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 breast squamous cell carcinoma 32.1 ERBB2 KRT5
2 spindle cell carcinoma 30.2 KRT5 PGR
3 carcinosarcoma 30.1 ERBB2 PGR
4 adenoid cystic carcinoma 29.7 ERBB2 KRT5 PGR
5 breast mucoepidermoid carcinoma 11.3
6 adenosquamous breast carcinoma 11.3
7 mixed epithelial/mesenchymal metaplastic breast carcinoma 11.3
8 breast cancer 10.5
9 fibromatosis 10.2
10 sarcoma 10.1
11 breast cystic hypersecretory carcinoma 10.1 ERBB2 KRT5
12 hidradenocarcinoma 10.1 ERBB2 KRT5
13 tonsil cancer 10.1 ERBB2 KRT5
14 cervical clear cell adenocarcinoma 10.0 KRT5 PGR
15 sweat gland disease 10.0 KRT5 PGR
16 scirrhous adenocarcinoma 10.0 ERBB2 PGR
17 breast apocrine carcinoma 10.0 ERBB2 PGR
18 glassy cell carcinoma of the cervix 10.0 ERBB2 PGR
19 intracystic papillary adenoma 10.0 ERBB2 PGR
20 progesterone-receptor negative breast cancer 10.0 ERBB2 PGR
21 breast medullary carcinoma 10.0 ERBB2 PGR
22 breast scirrhous carcinoma 10.0 ERBB2 PGR
23 progesterone-receptor positive breast cancer 10.0 ERBB2 PGR
24 breast adenoid cystic carcinoma 10.0 ERBB2 PGR
25 uterine body mixed cancer 10.0 ERBB2 PGR
26 microglandular adenosis 10.0 ERBB2 PGR
27 inflammatory breast carcinoma 10.0 ERBB2 PGR
28 luminal breast carcinoma 10.0 ERBB2 PGR
29 uterine corpus cancer 10.0 ERBB2 PGR
30 mixed cell type cancer 10.0 ERBB2 PGR
31 mammary paget's disease 10.0 ERBB2 PGR
32 bilateral breast cancer 10.0 ERBB2 PGR
33 primary peritoneal carcinoma 10.0 ERBB2 PGR
34 tubular adenocarcinoma 10.0 ERBB2 PGR
35 fallopian tube carcinoma 10.0 ERBB2 PGR
36 papillary adenocarcinoma 10.0 ERBB2 PGR
37 estrogen-receptor negative breast cancer 10.0 ERBB2 PGR
38 breast fibroadenoma 10.0 ERBB2 PGR
39 malignant ovarian surface epithelial-stromal neoplasm 10.0 ERBB2 PGR
40 ovary epithelial cancer 10.0 ERBB2 PGR
41 female breast cancer 10.0 ERBB2 PGR
42 serous cystadenocarcinoma 10.0 ERBB2 PGR
43 cystadenocarcinoma 10.0 ERBB2 PGR
44 cervical adenocarcinoma 10.0 ERBB2 PGR
45 estrogen-receptor positive breast cancer 10.0 ERBB2 PGR
46 osteogenic sarcoma 10.0
47 intraductal papilloma 10.0
48 melanoma 10.0
49 papilloma 10.0
50 pleomorphic adenoma 10.0

Graphical network of the top 20 diseases related to Breast Metaplastic Carcinoma:



Diseases related to Breast Metaplastic Carcinoma

Symptoms & Phenotypes for Breast Metaplastic Carcinoma

UMLS symptoms related to Breast Metaplastic Carcinoma:


pain

MGI Mouse Phenotypes related to Breast Metaplastic Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 ERBB2 FEZF1 FEZF2 KRT5 PGR
2 craniofacial MP:0005382 9.26 ERBB2 FEZF1 FEZF2 KRT5
3 mortality/aging MP:0010768 9.02 ERBB2 FEZF1 FEZF2 KRT5 PGR

Drugs & Therapeutics for Breast Metaplastic Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Metaplastic Carcinoma

Genetic Tests for Breast Metaplastic Carcinoma

Anatomical Context for Breast Metaplastic Carcinoma

MalaCards organs/tissues related to Breast Metaplastic Carcinoma:

41
Breast, Skin, Bone, Lymph Node, Ovary, Tonsil, Cervix

Publications for Breast Metaplastic Carcinoma

Articles related to Breast Metaplastic Carcinoma:

(show top 50) (show all 84)
# Title Authors Year
1
Metaplastic carcinoma of the breast with mesenchymal differentiation (carcinosarcoma). A unique presentation of an aggressive malignancy and literature review. ( 29504519 )
2018
2
Rare variant of metaplastic carcinoma of the breast: a case report and review of the literature. ( 29463294 )
2018
3
Imaging Findings of Metaplastic Carcinoma of the Breast with Pathologic Correlation. ( 30039058 )
2018
4
Metaplastic carcinoma of the breast: A diagnostic challenge on fine needle aspiration cytology. ( 30043535 )
2018
5
Metaplastic Carcinoma of the Breast Is More Aggressive Than Triple-negative Breast Cancer: A Study From a Single Institution and Review of Literature. ( 28529029 )
2017
6
Clinicopathological characteristics and prognosis of metaplastic carcinoma of the breast. ( 28781640 )
2017
7
Metaplastic carcinoma of the breast with widespread telangiectatic form of osteosarcomatous differentiation. ( 26645580 )
2016
8
Pregnancy-like hyperplasia and cystic hypersecretory changes adjacent to metaplastic carcinoma of the breast. ( 26960660 )
2016
9
Metaplastic carcinoma of the breast: Imaging and pathological features. ( 27895758 )
2016
10
A case of matrix-producing metaplastic carcinoma of the breast exhibiting similarities to pleomorphic adenoma on fine-needle aspiration cytology. ( 26823890 )
2015
11
Prognostic factors in metaplastic carcinoma of the breast: a multi-institutional study. ( 25422911 )
2015
12
Cancer stem cell and epithelial-mesenchymal transition markers predict worse outcome in metaplastic carcinoma of the breast. ( 25677743 )
2015
13
Metaplastic carcinoma of the breast. ( 26030252 )
2015
14
Aggressive Metaplastic Carcinoma of the Breast with Osteoclastic Giant Cells. ( 26629304 )
2015
15
Fibromatosis-like metaplastic carcinoma of the breast has a claudin-low immunohistochemical phenotype. ( 24903673 )
2014
16
Metaplastic carcinoma of the breast: Treatment, results and prognostic factors based on international literature. ( 24195912 )
2014
17
Metaplastic carcinoma of the breast with chondroid differentiation (matrix-producing carcinoma): study of the diagnostic cost-effectiveness of fine-needle aspiration biopsy and needle core biopsy. ( 24246799 )
2014
18
Metaplastic carcinoma of the breast with rhabdo-myosarcomatous element. ( 25006301 )
2014
19
Metaplastic carcinoma of the breast: an immunohistochemical study. ( 25030022 )
2014
20
Metaplastic carcinoma of the breast: A case report with review of literature. ( 25494151 )
2014
21
Metaplastic carcinoma of the breast: A rare carcinoma with chondroid metaplasia. ( 25931882 )
2014
22
Metaplastic carcinoma of the breast with transformation from adenosquamous carcinoma to osteosarcomatoid and spindle cell morphology. ( 24137400 )
2013
23
The prognostic significance of metaplastic carcinoma of the breast (MCB)--a case controlled comparison study with infiltrating ductal carcinoma. ( 23787124 )
2013
24
Breast metaplastic carcinoma with unusual small cell component. ( 23507669 )
2012
25
Low-grade fibromatosis-like spindle cell metaplastic carcinoma of the breast: a case report and literature review. ( 22444721 )
2012
26
Metaplastic carcinoma of the breast with dominant squamous and sebaceous differentiation in the primary tumor and osteochondroid metaplasia in a distant metastasis: report of a case with review of sebaceous differentiation in breast tumors. ( 21865268 )
2012
27
Metaplastic carcinoma of the breast: multimodality imaging and histopathologic assessment. ( 22090465 )
2012
28
Review of metaplastic carcinoma of the breast: imaging findings and pathologic features. ( 22616038 )
2012
29
Twelve cases of metaplastic carcinoma of the breast: experience of the university hospital of Fez Morocco. ( 20454905 )
2011
30
Challenges to diagnose metaplastic carcinoma of the breast through cytologic methods: an eight-case series. ( 21244696 )
2011
31
Metaplastic carcinoma of the breast with neuroectodermal stromal component. ( 21437182 )
2011
32
Responses to liposomal Doxorubicin, bevacizumab, and temsirolimus in metaplastic carcinoma of the breast: biologic rationale and implications for stem-cell research in breast cancer. ( 21482991 )
2011
33
Metaplastic carcinoma of the breast: cytological diagnosis and diagnostic pitfalls. ( 21791899 )
2011
34
Lack of efficacy to systemic chemotherapy for treatment of metaplastic carcinoma of the breast in the modern era. ( 21792625 )
2011
35
A case of metaplastic carcinoma of the breast. ( 21803877 )
2011
36
Metaplastic carcinoma of the breast with high grade spindle cell component with osteoid formation--a rare case report. ( 21954743 )
2011
37
Metaplastic carcinoma of the breast: clinicopathological features and immunohistochemical analysis. ( 22331717 )
2011
38
Keloid type of fibromatosis-like metaplastic carcinoma of the breast with transformation into biphasic tumour in recurrences and lymph node metastases. ( 20716174 )
2010
39
Metaplastic carcinoma of the breast. ( 20236684 )
2010
40
Metaplastic carcinoma of the breast-a rare neoplasm with transitional cell differentiation: an exceptional feature. ( 20551558 )
2010
41
Fibromatosislike metaplastic carcinoma of the breast as a diagnostic pitfall for fine needle aspiration cytology: a case report. ( 20968161 )
2010
42
A case of metaplastic carcinoma of the breast responsive to chemotherapy with Ifosfamide and Etoposide: improved antitumor response by targeting sarcomatous features. ( 21070449 )
2010
43
Mixed metaplastic carcinoma of the breast associated with pregnancy: Diagnostic dilemmas in fine-needle aspiration cytology. ( 19459158 )
2009
44
Report of a metaplastic carcinoma of the breast with multi-directional differentiation: an adenoid cystic carcinoma, a spindle cell carcinoma and melanoma. ( 18283489 )
2008
45
Metaplastic carcinoma of the breast (carcinosarcoma variant): a case report. ( 17883089 )
2007
46
Fine-needle aspiration cytology of metaplastic carcinoma of the breast. ( 16798932 )
2007
47
Metaplastic carcinoma of the breast, an unusual disease with worse prognosis: the experience of the European Institute of Oncology and review of the literature. ( 17009109 )
2007
48
Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition. ( 17603561 )
2007
49
Metaplastic carcinoma of the breast: a retrospective review. ( 16246496 )
2006
50
Metaplastic carcinoma of the breast with neuroglial differentiation. ( 16253505 )
2006

Variations for Breast Metaplastic Carcinoma

Cosmic variations for Breast Metaplastic Carcinoma:

9 (show top 50) (show all 54)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6956502 ZFHX3 breast,NS,carcinoma,metaplastic carcinoma c.4282G>A p.A1428T 16:72798400-72798400 24
2 COSM10648 TP53 breast,NS,carcinoma,metaplastic carcinoma c.524G>A p.R175H 17:7675088-7675088 24
3 COSM10645 TP53 breast,NS,carcinoma,metaplastic carcinoma c.527G>T p.C176F 17:7675085-7675085 24
4 COSM10726 TP53 breast,NS,carcinoma,metaplastic carcinoma c.856G>A p.E286K 17:7673764-7673764 24
5 COSM44268 TP53 breast,NS,carcinoma,metaplastic carcinoma c.559+1G>T p.? 17:7675052-7675052 24
6 COSM10662 TP53 breast,NS,carcinoma,metaplastic carcinoma c.743G>A p.R248Q 17:7674220-7674220 24
7 COSM11582 TP53 breast,NS,carcinoma,metaplastic carcinoma c.395A>G p.K132R 17:7675217-7675217 24
8 COSM6918851 RBM10 breast,NS,carcinoma,metaplastic carcinoma c.688C>G p.R230G 23:47179127-47179127 24
9 COSM5991648 RB1 breast,NS,carcinoma,metaplastic carcinoma c.1421+1G>C p.? 13:48380085-48380085 24
10 COSM5991640 RB1 breast,NS,carcinoma,metaplastic carcinoma c.607+2T>A p.? 13:48349025-48349025 24
11 COSM1968237 PTEN breast,NS,carcinoma,metaplastic carcinoma c.402G>T p.M134I 10:87933161-87933161 24
12 COSM775 PIK3CA breast,NS,carcinoma,metaplastic carcinoma c.3140A>G p.H1047R 3:179234297-179234297 24
13 COSM763 PIK3CA breast,NS,carcinoma,metaplastic carcinoma c.1633G>A p.E545K 3:179218303-179218303 24
14 COSM6966234 NF1 breast,NS,carcinoma,metaplastic carcinoma c.634G>C p.V212L 17:31181469-31181469 24
15 COSM6916545 NF1 breast,NS,carcinoma,metaplastic carcinoma c.3082G>T p.D1028Y 17:31230351-31230351 24
16 COSM6922156 IRS1 breast,NS,carcinoma,metaplastic carcinoma c.3564C>A p.F1188L 2:226795175-226795175 24
17 COSM489 HRAS breast,NS,carcinoma,metaplastic carcinoma c.38G>T p.G13V 11:534285-534285 24
18 COSM6918850 FLT4 breast,NS,carcinoma,metaplastic carcinoma c.2890G>T p.V964L 5:180618881-180618881 24
19 COSM6918844 FBXW7 breast,NS,carcinoma,metaplastic carcinoma c.1418+2T>G p.? 4:152328206-152328206 24
20 COSM5677 CTNNB1 breast,NS,carcinoma,metaplastic carcinoma c.98C>G p.S33C 3:41224610-41224610 24
21 COSM5732 CTNNB1 breast,NS,carcinoma,metaplastic carcinoma c.125C>G p.T42R 3:41224637-41224637 24
22 COSM27311 CTNNB1 breast,NS,carcinoma,metaplastic carcinoma c.97T>A p.S33T 3:41224609-41224609 24
23 COSM5666 CTNNB1 breast,NS,carcinoma,metaplastic carcinoma c.110C>A p.S37Y 3:41224622-41224622 24
24 COSM12475 CDKN2A breast,NS,carcinoma,metaplastic carcinoma c.238C>T p.R80* 9:21971121-21971121 24
25 COSM12736 CDKN2A breast,NS,carcinoma,metaplastic carcinoma c.104G>T p.G35V 9:21974724-21974724 24
26 COSM19476 APC breast,NS,carcinoma,metaplastic carcinoma c.4616C>G p.S1539* 5:112840210-112840210 24
27 COSM18942 APC breast,NS,carcinoma,metaplastic carcinoma c.3928A>T p.K1310* 5:112839522-112839522 24
28 COSM99914 breast,NS,carcinoma,metaplastic carcinoma c.524G>A p.R175H 17:7675088-7675088 24
29 COSM6985595 breast,NS,carcinoma,metaplastic carcinoma c.104G>T p.G35V 9:21974724-21974724 24
30 COSM308310 breast,NS,carcinoma,metaplastic carcinoma c.395A>G p.K132R 17:7675217-7675217 24
31 COSM3388223 breast,NS,carcinoma,metaplastic carcinoma c.395A>G p.K132R 17:7675217-7675217 24
32 COSM308311 breast,NS,carcinoma,metaplastic carcinoma c.395A>G p.K132R 17:7675217-7675217 24
33 COSM99021 breast,NS,carcinoma,metaplastic carcinoma c.464G>A p.R155Q 17:7674220-7674220 24
34 COSM94986 breast,NS,carcinoma,metaplastic carcinoma c.3140A>G p.H1047R 3:179234297-179234297 24
35 COSM99020 breast,NS,carcinoma,metaplastic carcinoma c.743G>A p.R248Q 17:7674220-7674220 24
36 COSM6985594 breast,NS,carcinoma,metaplastic carcinoma c.104G>T p.G35V 9:21974724-21974724 24
37 COSM99023 breast,NS,carcinoma,metaplastic carcinoma c.128G>A p.R43H 17:7675088-7675088 24
38 COSM99602 breast,NS,carcinoma,metaplastic carcinoma c.743G>A p.R248Q 17:7674220-7674220 24
39 COSM1640830 breast,NS,carcinoma,metaplastic carcinoma c.743G>A p.R248Q 17:7674220-7674220 24
40 COSM6918843 breast,NS,carcinoma,metaplastic carcinoma c.1418+2T>G p.? 4:152328206-152328206 24
41 COSM99024 breast,NS,carcinoma,metaplastic carcinoma c.245G>A p.R82H 17:7675088-7675088 24
42 COSM6918849 breast,NS,carcinoma,metaplastic carcinoma c.2890G>T p.V964L 5:180618881-180618881 24
43 COSM6966233 breast,NS,carcinoma,metaplastic carcinoma c.634G>C p.V212L 17:31181469-31181469 24
44 COSM6918845 breast,NS,carcinoma,metaplastic carcinoma c.1178+2T>G p.? 4:152328206-152328206 24
45 COSM6918847 breast,NS,carcinoma,metaplastic carcinoma c.890+2T>G p.? 4:152328206-152328206 24
46 COSM1646844 breast,NS,carcinoma,metaplastic carcinoma c.395A>G p.K132R 17:7675217-7675217 24
47 COSM6918848 breast,NS,carcinoma,metaplastic carcinoma c.701+2T>G p.? 4:152328206-152328206 24
48 COSM6918846 breast,NS,carcinoma,metaplastic carcinoma c.1064+2T>G p.? 4:152328206-152328206 24
49 COSM308312 breast,NS,carcinoma,metaplastic carcinoma c.116A>G p.K39R 17:7675217-7675217 24
50 COSM1640851 breast,NS,carcinoma,metaplastic carcinoma c.524G>A p.R175H 17:7675088-7675088 24

Expression for Breast Metaplastic Carcinoma

Search GEO for disease gene expression data for Breast Metaplastic Carcinoma.

Pathways for Breast Metaplastic Carcinoma

Pathways related to Breast Metaplastic Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.66 ERBB2 PGR

GO Terms for Breast Metaplastic Carcinoma

Biological processes related to Breast Metaplastic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.54 ERBB2 FEZF1 FEZF2
2 positive regulation of neuron differentiation GO:0045666 9.4 FEZF1 FEZF2
3 forebrain development GO:0030900 9.32 FEZF1 FEZF2
4 regulation of neurogenesis GO:0050767 9.26 FEZF1 FEZF2
5 telencephalon development GO:0021537 9.16 FEZF1 FEZF2
6 cell dedifferentiation GO:0043697 8.96 FEZF1 FEZF2
7 forebrain anterior/posterior pattern specification GO:0021797 8.62 FEZF1 FEZF2

Molecular functions related to Breast Metaplastic Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.13 FEZF1 FEZF2 PGR
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 8.8 FEZF1 FEZF2 PGR

Sources for Breast Metaplastic Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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