Aliases & Classifications for Breast Mucinous Carcinoma

MalaCards integrated aliases for Breast Mucinous Carcinoma:

Name: Breast Mucinous Carcinoma 12 15
Mucinous Carcinoma of Breast 12 74
Invasive Mucinous Breast Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3610
NCIt 51 C9131
UMLS 74 C1334807

Summaries for Breast Mucinous Carcinoma

Disease Ontology : 12 A breast adenocarcinoma in which at least one half of the tumor volume is extracellular mucin throughout.

MalaCards based summary : Breast Mucinous Carcinoma, also known as mucinous carcinoma of breast, is related to breast mucinous cystadenocarcinoma and breast columnar cell mucinous carcinoma, and has symptoms including pain An important gene associated with Breast Mucinous Carcinoma is CALR (Calreticulin), and among its related pathways/superpathways are Homologous DNA Pairing and Strand Exchange and Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA). Affiliated tissues include breast and lung, and related phenotypes are Reduced mammosphere formation and embryo

Related Diseases for Breast Mucinous Carcinoma

Diseases related to Breast Mucinous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 breast mucinous cystadenocarcinoma 11.3
2 breast columnar cell mucinous carcinoma 11.3
3 adenocarcinoma 9.9
4 urachal adenocarcinoma 9.9
5 hereditary breast ovarian cancer syndrome 9.6 RAD51C RAD51D

Graphical network of the top 20 diseases related to Breast Mucinous Carcinoma:



Diseases related to Breast Mucinous Carcinoma

Symptoms & Phenotypes for Breast Mucinous Carcinoma

UMLS symptoms related to Breast Mucinous Carcinoma:


pain

GenomeRNAi Phenotypes related to Breast Mucinous Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 8.92 CALR POLD1 RAD51C SLC16A3

MGI Mouse Phenotypes related to Breast Mucinous Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 8.92 CALR POLD1 RAD51C RAD51D

Drugs & Therapeutics for Breast Mucinous Carcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 3D-CRT, Proton, or Brachytherapy APBI in Treating Patients With Invasive and Non-invasive Breast Cancer Active, not recruiting NCT03391388 Phase 2
2 Radiation Therapy in Treating Post-Menopausal Women With Early Stage Breast Cancer Undergoing Surgery Terminated NCT01754519 Phase 2

Search NIH Clinical Center for Breast Mucinous Carcinoma

Genetic Tests for Breast Mucinous Carcinoma

Anatomical Context for Breast Mucinous Carcinoma

MalaCards organs/tissues related to Breast Mucinous Carcinoma:

42
Breast, Lung

Publications for Breast Mucinous Carcinoma

Articles related to Breast Mucinous Carcinoma:

# Title Authors Year
1
Severe Bilateral Breast Mucinous Carcinoma with Bilateral Lungs and Cutaneous Metastasis: A Case Report and Literature Review. ( 29707398 )
2018
2
Urachal adenocarcinoma that metastasized to breast was misinterpreted as primary breast mucinous carcinoma: A rare case report and literature review. ( 27583877 )
2016
3
Occurrence of Breast Mucinous Carcinoma After Autologous Fat Grating for Breast Augmentation. ( 26721250 )
2016
4
Biochemical and ultrastructural correlations of calreticulin and thioredoxin expression in breast mucinous carcinoma and infiltrating ductal carcinoma non-special type. ( 20929309 )
2011

Variations for Breast Mucinous Carcinoma

Cosmic variations for Breast Mucinous Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM12459 PIK3CA breast,NS,carcinoma,mucinous c.1637A>G p.Q546R 3:179218307-179218307 0
2 COSM6909041 PAK5 breast,NS,carcinoma,mucinous c.660G>T p.Q220H 20:9580475-9580475 0
3 COSM6865922 NCOR1 breast,NS,carcinoma,mucinous c.242+1G>T p.? 17:16186553-16186553 0
4 COSM6904316 KIT breast,NS,carcinoma,mucinous c.1549C>T p.H517Y 4:54727226-54727226 0
5 COSM436500 ERBB2 breast,NS,carcinoma,mucinous c.2329G>C p.V777L 17:39724747-39724747 0
6 COSM953790 AKT1 breast,NS,carcinoma,mucinous c.238T>C p.W80R 14:104776708-104776708 0

Expression for Breast Mucinous Carcinoma

Search GEO for disease gene expression data for Breast Mucinous Carcinoma.

Pathways for Breast Mucinous Carcinoma

GO Terms for Breast Mucinous Carcinoma

Cellular components related to Breast Mucinous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromosome, telomeric region GO:0000784 9.16 POLD1 RAD51D
2 replication fork GO:0005657 8.96 RAD51C RAD51D
3 Rad51B-Rad51C-Rad51D-XRCC2 complex GO:0033063 8.62 RAD51C RAD51D

Biological processes related to Breast Mucinous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.43 POLD1 RAD51C RAD51D
2 DNA recombination GO:0006310 9.37 RAD51C RAD51D
3 DNA repair GO:0006281 9.33 POLD1 RAD51C RAD51D
4 double-strand break repair via homologous recombination GO:0000724 9.32 RAD51C RAD51D
5 telomere maintenance GO:0000723 8.96 POLD1 RAD51D
6 reciprocal meiotic recombination GO:0007131 8.62 RAD51C RAD51D

Molecular functions related to Breast Mucinous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.46 CALR POLD1 RAD51C RAD51D
2 DNA-dependent ATPase activity GO:0008094 8.96 RAD51C RAD51D
3 four-way junction DNA binding GO:0000400 8.62 RAD51C RAD51D

Sources for Breast Mucinous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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