Aliases & Classifications for Breast Mucinous Carcinoma

MalaCards integrated aliases for Breast Mucinous Carcinoma:

Name: Breast Mucinous Carcinoma 12 15
Mucinous Carcinoma of Breast 12 73
Invasive Mucinous Breast Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3610
NCIt 50 C9131
SNOMED-CT 68 444712000
UMLS 73 C1334807

Summaries for Breast Mucinous Carcinoma

MalaCards based summary : Breast Mucinous Carcinoma, also known as mucinous carcinoma of breast, is related to adenocarcinoma and urachal adenocarcinoma, and has symptoms including pain An important gene associated with Breast Mucinous Carcinoma is CALR (Calreticulin), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template. Affiliated tissues include breast and lung.

Related Diseases for Breast Mucinous Carcinoma

Diseases related to Breast Mucinous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 9.7
2 urachal adenocarcinoma 9.7
3 polymerase proofreading-related adenomatous polyposis 9.2 POLD1 POLE
4 lynch syndrome 9.0 POLD1 POLE

Symptoms & Phenotypes for Breast Mucinous Carcinoma

UMLS symptoms related to Breast Mucinous Carcinoma:


pain

Drugs & Therapeutics for Breast Mucinous Carcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 3D-CRT, Proton, or Brachytherapy APBI in Treating Patients With Invasive and Non-invasive Breast Cancer Active, not recruiting NCT03391388 Phase 2
2 Radiation Therapy in Treating Post-Menopausal Women With Early Stage Breast Cancer Undergoing Surgery Terminated NCT01754519 Phase 2

Search NIH Clinical Center for Breast Mucinous Carcinoma

Genetic Tests for Breast Mucinous Carcinoma

Anatomical Context for Breast Mucinous Carcinoma

MalaCards organs/tissues related to Breast Mucinous Carcinoma:

41
Breast, Lung

Publications for Breast Mucinous Carcinoma

Articles related to Breast Mucinous Carcinoma:

# Title Authors Year
1
Severe Bilateral Breast Mucinous Carcinoma with Bilateral Lungs and Cutaneous Metastasis: A Case Report and Literature Review. ( 29707398 )
2018
2
Urachal adenocarcinoma that metastasized to breast was misinterpreted as primary breast mucinous carcinoma: A rare case report and literature review. ( 27583877 )
2016
3
Occurrence of Breast Mucinous Carcinoma After Autologous Fat Grating for Breast Augmentation. ( 26721250 )
2016
4
Biochemical and ultrastructural correlations of calreticulin and thioredoxin expression in breast mucinous carcinoma and infiltrating ductal carcinoma non-special type. ( 20929309 )
2011

Variations for Breast Mucinous Carcinoma

Cosmic variations for Breast Mucinous Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM12459 PIK3CA breast,NS,carcinoma,mucinous c.1637A>G p.Q546R 3:179218307-179218307 12
2 COSM6909041 PAK5 breast,NS,carcinoma,mucinous c.660G>T p.Q220H 20:9580475-9580475 12
3 COSM6865922 NCOR1 breast,NS,carcinoma,mucinous c.242+1G>T p.? 17:16186553-16186553 12
4 COSM6904316 KIT breast,NS,carcinoma,mucinous c.1549C>T p.H517Y 4:54727226-54727226 12
5 COSM436500 ERBB2 breast,NS,carcinoma,mucinous c.2329G>C p.V777L 17:39724747-39724747 12
6 COSM953790 AKT1 breast,NS,carcinoma,mucinous c.238T>C p.W80R 14:104776708-104776708 12

Expression for Breast Mucinous Carcinoma

Search GEO for disease gene expression data for Breast Mucinous Carcinoma.

Pathways for Breast Mucinous Carcinoma

Pathways related to Breast Mucinous Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.61 POLD1 POLE RAD51D
2
Show member pathways
11.69 POLD1 POLE
3
Show member pathways
11.55 POLD1 RAD51D
4 11.54 CALR POLD1 POLE
5
Show member pathways
11.39 POLD1 POLE
6
Show member pathways
11.25 POLD1 POLE
7
Show member pathways
11.1 POLD1 POLE RAD51D
8 10.79 POLD1 POLE

GO Terms for Breast Mucinous Carcinoma

Cellular components related to Breast Mucinous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromosome, telomeric region GO:0000784 8.62 POLD1 RAD51D

Biological processes related to Breast Mucinous Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.63 POLD1 POLE RAD51D
2 DNA repair GO:0006281 9.61 POLD1 POLE RAD51D
3 DNA replication GO:0006260 9.49 POLD1 POLE
4 nucleic acid phosphodiester bond hydrolysis GO:0090305 9.48 POLD1 POLE
5 telomere maintenance GO:0000723 9.4 POLD1 RAD51D
6 DNA biosynthetic process GO:0071897 9.37 POLD1 POLE
7 telomere maintenance via semi-conservative replication GO:0032201 9.32 POLD1 POLE
8 nucleotide-excision repair, DNA gap filling GO:0006297 9.26 POLD1 POLE
9 base-excision repair, gap-filling GO:0006287 9.16 POLD1 POLE
10 DNA replication proofreading GO:0045004 8.96 POLD1 POLE
11 DNA synthesis involved in DNA repair GO:0000731 8.8 POLD1 POLE RAD51D

Molecular functions related to Breast Mucinous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.71 CALR POLD1 POLE RAD51D
2 nucleotide binding GO:0000166 9.43 POLD1 POLE RAD51D
3 nucleotidyltransferase activity GO:0016779 9.37 POLD1 POLE
4 iron-sulfur cluster binding GO:0051536 9.32 POLD1 POLE
5 4 iron, 4 sulfur cluster binding GO:0051539 9.16 POLD1 POLE
6 DNA-directed DNA polymerase activity GO:0003887 8.96 POLD1 POLE
7 3-5 exonuclease activity GO:0008408 8.62 POLD1 POLE

Sources for Breast Mucinous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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