MCID: BRS010
MIFTS: 26

Breast Mucoepidermoid Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Breast Mucoepidermoid Carcinoma

MalaCards integrated aliases for Breast Mucoepidermoid Carcinoma:

Name: Breast Mucoepidermoid Carcinoma 12 15
Mucoepidermoid Carcinoma of the Breast 12
Mucoepidermoid Carcinoma of Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4679
NCIt 50 C5166
UMLS 70 C1334813

Summaries for Breast Mucoepidermoid Carcinoma

Disease Ontology : 12 A breast metaplastic carcinoma that is characterized by the presence of four cell types (basaloid, intermediate, epidermoid, and mucinous) in varying proportions.

MalaCards based summary : Breast Mucoepidermoid Carcinoma, also known as mucoepidermoid carcinoma of the breast, is related to mucoepidermoid carcinoma and rare tumor. An important gene associated with Breast Mucoepidermoid Carcinoma is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways/superpathways are B Cell Receptor Signaling Pathway (sino) and VEGF Signaling. Affiliated tissues include breast, salivary gland and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Breast Mucoepidermoid Carcinoma

Diseases related to Breast Mucoepidermoid Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 mucoepidermoid carcinoma 29.4 MUC5AC MAML2 KRT5 CRTC1
2 rare tumor 10.2
3 lacrimal gland mucoepidermoid carcinoma 10.2 MAML2 CRTC1
4 warthin tumor 10.1 MAML2 CRTC1
5 schneiderian carcinoma 10.1 MAML2 CRTC1
6 lung adenoid cystic carcinoma 10.1 MAML2 CRTC1
7 pleomorphic adenoma carcinoma 10.1 MAML2 CRTC1
8 pleomorphic adenoma 10.1 MAML2 CRTC1
9 malignant acrospiroma 10.1 MAML2 KRT5
10 breast metaplastic carcinoma 10.0 MAML2 KRT5
11 eccrine sweat gland cancer 10.0 MAML2 KRT5
12 eccrine acrospiroma 10.0 MAML2 KRT5
13 cervical adenosquamous carcinoma 10.0 MAML2 CRTC1
14 eccrine sweat gland neoplasm 10.0 MAML2 KRT5
15 lung mucoepidermoid carcinoma 10.0 MUC5AC MAML2
16 pancreatic adenosquamous carcinoma 9.9 MAML2 CRTC1
17 keratinizing squamous cell carcinoma 9.9 MAML2 KRT5
18 cutaneous mucoepidermoid carcinoma 9.9 MAML2 KRT5 CRTC1
19 clear cell hidradenoma 9.9 MAML2 KRT5 CRTC1
20 hidradenoma 9.9 MAML2 KRT5 CRTC1
21 sweat gland benign neoplasm 9.9 MAML2 KRT5 CRTC1
22 tonsil cancer 9.9 MAML2 KRT5 CRTC1
23 solid adenocarcinoma with mucin production 9.9 MUC5AC KRT5
24 oropharynx cancer 9.9 MAML2 KRT5 CRTC1
25 salivary gland disease 9.9 MAML2 KRT5 CRTC1
26 adenosquamous carcinoma 9.9 MAML2 KRT5 CRTC1
27 sweat gland disease 9.7 MAML2 KRT5
28 bile duct mucoepidermoid carcinoma 9.6 MUC5AC MAML2 KRT5 CRTC1
29 endobronchial lipoma 9.6 MUC5AC MAML2 KRT5 CRTC1

Graphical network of the top 20 diseases related to Breast Mucoepidermoid Carcinoma:



Diseases related to Breast Mucoepidermoid Carcinoma

Symptoms & Phenotypes for Breast Mucoepidermoid Carcinoma

GenomeRNAi Phenotypes related to Breast Mucoepidermoid Carcinoma according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-102 10.1 MAP3K1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-110 10.1 MAP2K4
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-121 10.1 MAP2K4
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 10.1 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 10.1 MAP2K4
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 10.1 KRT5
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 10.1 MAP2K4
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 10.1 MAP2K4
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-35 10.1 MAP3K1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 10.1 MAP2K4 MAP3K1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 10.1 KRT5
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 10.1 MAP2K4
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 10.1 MAP2K4
14 Decreased viability GR00221-A-1 9.76 MAP2K4
15 Decreased viability GR00221-A-2 9.76 MAPK15
16 Decreased viability GR00221-A-3 9.76 MAP2K4
17 Decreased viability GR00221-A-4 9.76 MAP2K4
18 Decreased viability GR00231-A 9.76 MAPK15
19 Decreased viability GR00301-A 9.76 MAP2K4 MAPK15
20 Decreased viability GR00402-S-2 9.76 MAPK15
21 Increased colony dispersion (increased number of colonies and decreased number of cells per colony) GR00212-A 8.96 MAP2K4 MAP3K1
22 Upregulation of NF-kappaB pathway after LMP1 stimulation GR00199-A-3 8.62 MAP3K1 MAPK15

MGI Mouse Phenotypes related to Breast Mucoepidermoid Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.17 CRTC1 KRT5 MAP2K4 MAP3K1 MAPK15 MUC5AC

Drugs & Therapeutics for Breast Mucoepidermoid Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Mucoepidermoid Carcinoma

Genetic Tests for Breast Mucoepidermoid Carcinoma

Anatomical Context for Breast Mucoepidermoid Carcinoma

MalaCards organs/tissues related to Breast Mucoepidermoid Carcinoma:

40
Breast, Salivary Gland, Lung, Tonsil

Publications for Breast Mucoepidermoid Carcinoma

Articles related to Breast Mucoepidermoid Carcinoma:

(show all 23)
# Title Authors PMID Year
1
Mucoepidermoid Carcinoma of the Breast With MAML2 Rearrangement: A Case Report and Literature Review. 61
32362174 2020
2
Breast mucoepidermoid carcinoma: a case report and review of literature. 61
33425121 2020
3
CRTC1-MAML2 fusion in mucoepidermoid carcinoma of the breast. 61
30380176 2019
4
Mutational screen of a panel of tumor genes in a case report of mucoepidermoid carcinoma of the breast from Jordan. 61
30251446 2018
5
Mucoepidermoid carcinoma of the breast: Four case reports and review of the literature. 61
29390541 2017
6
Primary mucoepidermoid carcinoma of the breast. 61
28397345 2017
7
Mucoepidermoid Carcinoma of the Breast Found during Treatment of Lymphoma. 61
28101030 2016
8
Primary mucoepidermoid carcinoma of the breast: a case report with immunohistochemical analysis and comparison with salivary gland mucoepidermoid carcinomas. 61
24166608 2013
9
Mucoepidermoid carcinoma of the breast. 61
23294278 2013
10
Mucoepidermoid carcinoma of the breast shares cytogenetic abnormality with mucoepidermoid carcinoma of the salivary gland: a case report with molecular analysis and review of the literature. 61
19200580 2009
11
Mucoepidermoid carcinoma of the breast. 61
17319792 2007
12
Fine needle aspiration cytology of high grade mucoepidermoid carcinoma of the breast: a case report. 61
16780034 2006
13
Mucoepidermoid carcinoma of the breast. 61
14634807 2004
14
High-grade mucoepidermoid carcinoma of the breast: case report. 61
9849021 1998
15
Mucoepidermoid carcinoma of the breast: a case report and review of the literature. 61
9542524 1998
16
Mucoepidermoid carcinoma of the breast. 61
9641234 1998
17
High-grade mucoepidermoid carcinoma of the breast. Fine needle aspiration cytology and clinicopathologic study of a case. 61
2929221 1989
18
Ultrastructural and immunohistochemical characteristics of mucoepidermoid carcinoma of the breast. 61
4029947 1985
19
High-grade mucoepidermoid carcinoma of the breast. 61
4054847 1985
20
Mucoepidermoid carcinoma of the breast: high grade variant. 61
4069771 1985
21
High-grade mucoepidermoid carcinoma of the breast. A case report. 61
6663220 1983
22
High-grade mucoepidermoid carcinoma of the breast. 61
6895301 1981
23
Low-grade mucoepidermoid carcinoma of the breast. 61
218522 1979

Variations for Breast Mucoepidermoid Carcinoma

Expression for Breast Mucoepidermoid Carcinoma

Search GEO for disease gene expression data for Breast Mucoepidermoid Carcinoma.

Pathways for Breast Mucoepidermoid Carcinoma

Pathways related to Breast Mucoepidermoid Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.97 MAPK15 MAP3K1 MAP2K4
2
Show member pathways
11.78 MAPK15 MAP3K1 MAP2K4
3 11.67 MAP3K1 MAP2K4 CRTC1
4
Show member pathways
11.41 MAP3K1 MAP2K4
5
Show member pathways
11.38 MUC5AC MAP3K1 MAP2K4
6 11.33 MAPK15 MAP2K4
7 11.1 MAP3K1 MAP2K4
8 11.08 MAP3K1 MAP2K4
9 11.05 MAP3K1 MAP2K4
10 10.8 MAP3K1 MAP2K4
11 9.74 MAP3K1 MAP2K4

GO Terms for Breast Mucoepidermoid Carcinoma

Biological processes related to Breast Mucoepidermoid Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to mechanical stimulus GO:0071260 8.96 MAP3K1 MAP2K4
2 MAPK cascade GO:0000165 8.8 MAPK15 MAP3K1 MAP2K4

Molecular functions related to Breast Mucoepidermoid Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein serine/threonine kinase activity GO:0004674 8.8 MAPK15 MAP3K1 MAP2K4

Sources for Breast Mucoepidermoid Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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