MCID: BRS029
MIFTS: 25

Breast Myoepithelial Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Breast Myoepithelial Carcinoma

MalaCards integrated aliases for Breast Myoepithelial Carcinoma:

Name: Breast Myoepithelial Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:6776
NCIt 49 C40395
UMLS 71 C1518167

Summaries for Breast Myoepithelial Carcinoma

Disease Ontology : 12 A breast carcinome that is composed entirely or almost entirely of malignant spindle cells with myoepithelial differentiation.

MalaCards based summary : Breast Myoepithelial Carcinoma is related to myoepithelial carcinoma and myoepithelioma. An important gene associated with Breast Myoepithelial Carcinoma is VIM (Vimentin), and among its related pathways/superpathways are Actin Nucleation by ARP-WASP Complex and nNOS Signaling in Skeletal Muscle. Affiliated tissues include breast, and related phenotypes are mortality/aging and muscle

Related Diseases for Breast Myoepithelial Carcinoma

Diseases related to Breast Myoepithelial Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
# Related Disease Score Top Affiliating Genes
1 myoepithelial carcinoma 30.8 VIM KRT14 ACTC1
2 myoepithelioma 30.0 VIM SERPINB5 KRT14 ACTC1
3 ameloblastic carcinoma 10.5 VIM KRT14
4 lymphangiectasis 10.5 VIM ACTC1
5 intravascular papillary endothelial hyperplasia 10.4 VIM ACTC1
6 glomangiomyoma 10.4 VIM ACTC1
7 angiocentric glioma 10.4 VIM ACTC1
8 cutaneous leiomyosarcoma 10.4 VIM ACTC1
9 vulvar sarcoma 10.4 ACTG2 ACTC1
10 parachordoma 10.4 VIM ACTC1
11 glomangioma 10.4 VIM ACTC1
12 reticulum cell sarcoma 10.4 VIM ACTC1
13 scrotum neoplasm 10.4 ACTG2 ACTC1
14 angiolipoma 10.4 VIM ACTC1
15 spindle cell lipoma 10.4 VIM ACTC1
16 ossifying fibromyxoid tumor 10.4 VIM ACTC1
17 granulosa cell tumor of the ovary 10.4 VIM ACTC1
18 dendritic cell tumor 10.4 VIM ACTC1
19 chondromyxoid fibroma 10.3 VIM ACTC1
20 epithelial-myoepithelial carcinoma 10.3 VIM KRT14
21 adenofibroma 10.3 VIM ACTC1
22 rhabdoid tumor predisposition syndrome 1 10.3 VIM ACTC1
23 lymphangiomatosis 10.3 VIM PGR
24 congenital fibrosarcoma 10.3 VIM ACTC1
25 endometrial mucinous adenocarcinoma 10.3 VIM PGR
26 oncocytic breast carcinoma 10.3 PGR KRT14
27 benign breast adenomyoepithelioma 10.3 KRT5 KRT14
28 congenital epulis 10.3 VIM PGR
29 pleomorphic liposarcoma 10.3 VIM ACTC1
30 epulis 10.3 VIM PGR
31 syringoma 10.3 VIM SERPINB5
32 liver fibroma 10.3 VIM KRT5
33 ceruminous adenocarcinoma 10.3 KRT5 KRT14
34 squamous cell bile duct carcinoma 10.3 KRT5 KRT14
35 epidermolysis bullosa simplex, autosomal recessive 1 10.3 KRT5 KRT14
36 micronodular basal cell carcinoma 10.3 KRT5 KRT14
37 perineurioma 10.3 VIM ACTC1
38 eccrine porocarcinoma 10.3 VIM KRT5
39 large cell acanthoma 10.3 KRT5 KRT14
40 spiradenoma 10.3 VIM KRT14 ACTC1
41 pericardial mesothelioma 10.3 VIM KRT5
42 eccrine acrospiroma 10.3 KRT5 KRT14
43 polyp of corpus uteri 10.3 PGR KRT14
44 eccrine sweat gland neoplasm 10.2 KRT5 KRT14
45 mucinous cystadenocarcinoma 10.2 VIM ACTC1
46 calcifying aponeurotic fibroma 10.2 PGR ACTC1
47 fibroma 10.2 VIM KRT14 ACTC1
48 adenoid squamous cell carcinoma 10.2 VIM KRT5
49 biphasic synovial sarcoma 10.2 VIM PGR
50 glycogen-rich clear cell breast carcinoma 10.2 PGR ACTC1

Graphical network of the top 20 diseases related to Breast Myoepithelial Carcinoma:



Diseases related to Breast Myoepithelial Carcinoma

Symptoms & Phenotypes for Breast Myoepithelial Carcinoma

MGI Mouse Phenotypes related to Breast Myoepithelial Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.7 ACTA1 ACTC1 ACTG1 ARG1 EZH2 KRT14
2 muscle MP:0005369 9.17 ACTA1 ACTA2 ACTC1 ACTG1 EZH2 PGR

Drugs & Therapeutics for Breast Myoepithelial Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Myoepithelial Carcinoma

Genetic Tests for Breast Myoepithelial Carcinoma

Anatomical Context for Breast Myoepithelial Carcinoma

MalaCards organs/tissues related to Breast Myoepithelial Carcinoma:

40
Breast

Publications for Breast Myoepithelial Carcinoma

Articles related to Breast Myoepithelial Carcinoma:

# Title Authors PMID Year
1
Myoepithelial carcinoma of the breast treated with surgery and chemotherapy. 61
23984136 2013

Variations for Breast Myoepithelial Carcinoma

Expression for Breast Myoepithelial Carcinoma

Search GEO for disease gene expression data for Breast Myoepithelial Carcinoma.

Pathways for Breast Myoepithelial Carcinoma

Pathways related to Breast Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 ACTG2 ACTG1 ACTA2 ACTA1
2
Show member pathways
12.5 ACTG2 ACTG1 ACTA2 ACTA1
3
Show member pathways
12.49 ACTG2 ACTG1 ACTA2 ACTA1
4
Show member pathways
12.45 ACTG2 ACTG1 ACTC1 ACTA2 ACTA1
5
Show member pathways
12.38 ACTG1 ACTC1 ACTA2 ACTA1
6
Show member pathways
12.3 ACTG2 ACTG1 ACTC1 ACTA2 ACTA1
7
Show member pathways
12.26 ACTG2 ACTG1 ACTA2 ACTA1
8
Show member pathways
12.26 ACTG2 ACTG1 ACTA2 ACTA1
9
Show member pathways
12.26 ACTG2 ACTG1 ACTC1 ACTA2 ACTA1
10
Show member pathways
12.25 ACTG2 ACTG1 ACTA2 ACTA1
11
Show member pathways
12.21 ACTG2 ACTG1 ACTA2 ACTA1
12
Show member pathways
12.05 VIM ACTG1 ACTA1
13 11.99 VIM KRT5 ACTG2 ACTG1 ACTC1 ACTA2
14 11.96 ACTG2 ACTG1 ACTA2 ACTA1
15
Show member pathways
11.89 ACTG2 ACTG1 ACTA2 ACTA1
16 11.84 ACTG2 ACTG1 ACTA2 ACTA1
17
Show member pathways
11.84 VIM KRT5 KRT14 ACTG1
18 11.59 ACTG2 ACTG1 ACTA2 ACTA1
19 11.46 ACTG2 ACTG1 ACTA2 ACTA1
20 11.41 VIM ACTG1 ACTC1 ACTA2 ACTA1
21 11.37 ACTG2 ACTG1 ACTC1 ACTA2 ACTA1
22 11.35 ACTG2 ACTG1 ACTA2 ACTA1
23 11.13 VIM ACTG1
24 11.05 ACTG2 ACTG1 ACTA2 ACTA1
25 10.84 ACTG2 ACTG1 ACTA2 ACTA1
26 10.62 ACTG2 ACTG1 ACTC1 ACTA2 ACTA1

GO Terms for Breast Myoepithelial Carcinoma

Cellular components related to Breast Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 10.14 WAPL VIM PGR KRT5 KRT14 ARG1
2 extracellular exosome GO:0070062 10.06 VIM KRT5 KRT14 ACTG2 ACTG1 ACTC1
3 extracellular space GO:0005615 10.04 SERPINB5 ARG1 ACTG2 ACTG1 ACTC1 ACTA2
4 cytoskeleton GO:0005856 9.99 VIM ACTG2 ACTG1 ACTC1 ACTA2 ACTA1
5 cytoplasm GO:0005737 9.77 WAPL VIM SERPINB5 PGR KRT5 KRT14
6 lamellipodium GO:0030027 9.73 ACTG2 ACTC1 ACTA2 ACTA1
7 actin cytoskeleton GO:0015629 9.72 ACTG2 ACTG1 ACTC1 ACTA2 ACTA1
8 blood microparticle GO:0072562 9.67 ACTG2 ACTG1 ACTC1 ACTA1
9 actin filament GO:0005884 9.65 ACTG1 ACTC1 ACTA1
10 cell body GO:0044297 9.56 ACTG2 ACTC1 ACTA2 ACTA1
11 filopodium GO:0030175 9.46 ACTG2 ACTC1 ACTA2 ACTA1
12 dynactin complex GO:0005869 8.92 ACTG2 ACTC1 ACTA2 ACTA1

Biological processes related to Breast Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle contraction GO:0006936 9.58 ACTG2 ACTA2 ACTA1
2 response to steroid hormone GO:0048545 9.48 ARG1 ACTA1
3 response to zinc ion GO:0010043 9.46 KRT14 ARG1
4 regulation of epithelial cell proliferation GO:0050678 9.43 SERPINB5 PGR
5 positive regulation of gene expression GO:0010628 9.43 VIM ACTG2 ACTG1 ACTC1 ACTA2 ACTA1
6 protein localization to chromatin GO:0071168 9.37 WAPL EZH2
7 muscle filament sliding GO:0030049 9.33 VIM ACTC1 ACTA1
8 hemidesmosome assembly GO:0031581 9.32 KRT5 KRT14
9 skeletal muscle thin filament assembly GO:0030240 9.26 ACTC1 ACTA1
10 mesenchyme migration GO:0090131 8.92 ACTG2 ACTC1 ACTA2 ACTA1

Molecular functions related to Breast Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myosin binding GO:0017022 9.16 ACTC1 ACTA1
2 structural constituent of cytoskeleton GO:0005200 9.02 VIM KRT5 KRT14 ACTG1 ACTA1
3 keratin filament binding GO:1990254 8.96 VIM KRT14

Sources for Breast Myoepithelial Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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