MCID: BRS029
MIFTS: 25

Breast Myoepithelial Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Breast Myoepithelial Carcinoma

MalaCards integrated aliases for Breast Myoepithelial Carcinoma:

Name: Breast Myoepithelial Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:6776
NCIt 49 C40395
UMLS 71 C1518167

Summaries for Breast Myoepithelial Carcinoma

Disease Ontology : 12 A breast carcinome that is composed entirely or almost entirely of malignant spindle cells with myoepithelial differentiation.

MalaCards based summary : Breast Myoepithelial Carcinoma is related to myoepithelial carcinoma and vulvar sarcoma. An important gene associated with Breast Myoepithelial Carcinoma is KRT14 (Keratin 14), and among its related pathways/superpathways are Phospholipase-C Pathway and Sweet Taste Signaling. Affiliated tissues include breast, and related phenotypes are mortality/aging and muscle

Related Diseases for Breast Myoepithelial Carcinoma

Diseases related to Breast Myoepithelial Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 myoepithelial carcinoma 30.9 KRT14 ACTC1
2 vulvar sarcoma 10.4 ACTG2 ACTC1
3 scrotum neoplasm 10.4 ACTG2 ACTC1
4 sweat gland neoplasm 10.3 KRT5 KRT14
5 spiradenoma 10.3 KRT14 ACTC1
6 benign breast adenomyoepithelioma 10.3 KRT5 KRT14
7 ischemic fasciitis 10.3 KRT14 ACTC1
8 polymorphous low-grade adenocarcinoma 10.3 SERPINB5 ACTC1
9 esophageal basaloid squamous cell carcinoma 10.3 KRT5 KRT14
10 ceruminous adenocarcinoma 10.3 KRT5 KRT14
11 epidermolysis bullosa simplex, autosomal recessive 1 10.3 KRT5 KRT14
12 odontoma 10.3 KRT5 KRT14
13 epithelial-myoepithelial carcinoma 10.3 KRT14 ACTC1
14 large cell acanthoma 10.3 KRT5 KRT14
15 eccrine sweat gland neoplasm 10.3 KRT5 KRT14
16 epidermolysis bullosa simplex with mottled pigmentation 10.3 KRT5 KRT14
17 oncocytic breast carcinoma 10.3 PGR KRT14
18 cervical clear cell adenocarcinoma 10.3 PGR KRT14
19 micronodular basal cell carcinoma 10.3 KRT5 KRT14
20 necrotizing sialometaplasia 10.3 KRT5 ACTC1
21 benign peritoneal mesothelioma 10.3 KRT5 KRT14
22 epidermolysis bullosa simplex, generalized 10.3 KRT5 KRT14
23 epidermolysis bullosa simplex, localized 10.2 KRT5 KRT14
24 comedo carcinoma 10.2 PGR KRT14
25 calcifying aponeurotic fibroma 10.2 PGR ACTC1
26 clear cell basal cell carcinoma 10.2 KRT5 KRT14
27 glycogen-rich clear cell breast carcinoma 10.2 PGR ACTC1
28 pseudosarcomatous fibromatosis 10.2 ACTG2 ACTC1
29 polyp of corpus uteri 10.2 PGR KRT14
30 rete ovarii adenoma 10.2 PGR KRT14
31 rete ovarii neoplasm 10.2 PGR KRT14
32 myoepithelioma 10.2 SERPINB5 KRT14 ACTC1
33 benign metastasizing leiomyoma 10.2 PGR ACTC1
34 cystic basal cell carcinoma 10.2 KRT5 KRT14
35 reticulate acropigmentation of kitamura 10.2 KRT5 KRT14
36 myxoid leiomyosarcoma 10.2 PGR ACTC1
37 bizarre leiomyoma 10.2 PGR ACTC1
38 borst-jadassohn intraepidermal carcinoma 10.2 KRT5 KRT14
39 pleomorphic adenoma 10.2 SERPINB5 KRT14 ACTC1
40 megacystis-microcolon-intestinal hypoperistalsis syndrome 10.2 ACTG2 ACTC1 ACTA2
41 juvenile nasopharyngeal angiofibroma 10.2 PGR ACTC1
42 hard palate cancer 10.1 KRT5 KRT14
43 lipid-rich breast carcinoma 10.1 PGR KRT5
44 vesiculobullous skin disease 10.1 KRT5 KRT14
45 papilloma 10.1 KRT5 KRT14 ACTC1
46 breast papillary carcinoma 10.1 PGR KRT5
47 external ear carcinoma 10.1 PGR KRT5
48 breast myoepithelial neoplasm 10.1 SERPINB5 KRT5 KRT14
49 breast adenomyoepithelioma 10.1 SERPINB5 KRT5 KRT14
50 cystic nephroma 10.1 PGR ACTC1

Graphical network of the top 20 diseases related to Breast Myoepithelial Carcinoma:



Diseases related to Breast Myoepithelial Carcinoma

Symptoms & Phenotypes for Breast Myoepithelial Carcinoma

MGI Mouse Phenotypes related to Breast Myoepithelial Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.7 ACTA1 ACTB ACTC1 ACTG1 ARG1 EZH2
2 muscle MP:0005369 9.17 ACTA1 ACTA2 ACTB ACTC1 ACTG1 EZH2

Drugs & Therapeutics for Breast Myoepithelial Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Myoepithelial Carcinoma

Genetic Tests for Breast Myoepithelial Carcinoma

Anatomical Context for Breast Myoepithelial Carcinoma

MalaCards organs/tissues related to Breast Myoepithelial Carcinoma:

40
Breast

Publications for Breast Myoepithelial Carcinoma

Articles related to Breast Myoepithelial Carcinoma:

# Title Authors PMID Year
1
Myoepithelial carcinoma of the breast treated with surgery and chemotherapy. 61
23984136 2013

Variations for Breast Myoepithelial Carcinoma

Expression for Breast Myoepithelial Carcinoma

Search GEO for disease gene expression data for Breast Myoepithelial Carcinoma.

Pathways for Breast Myoepithelial Carcinoma

Pathways related to Breast Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.94 ACTG2 ACTG1 ACTB ACTA2 ACTA1
2
Show member pathways
12.94 ACTG2 ACTG1 ACTB ACTA2 ACTA1
3
Show member pathways
12.91 ACTG2 ACTG1 ACTB ACTA2 ACTA1
4
Show member pathways
12.88 ACTG2 ACTG1 ACTB ACTA2 ACTA1
5
Show member pathways
12.85 ACTG2 ACTG1 ACTB ACTA2 ACTA1
6
Show member pathways
12.84 ACTG2 ACTG1 ACTB ACTA2 ACTA1
7
Show member pathways
12.82 ACTG2 ACTG1 ACTB ACTA2 ACTA1
8
Show member pathways
12.81 ACTG2 ACTG1 ACTB ACTA2 ACTA1
9
Show member pathways
12.76 ACTG2 ACTG1 ACTB ACTA2 ACTA1
10
Show member pathways
12.6 ACTG2 ACTG1 ACTB ACTA2 ACTA1
11
Show member pathways
12.59 ACTG2 ACTG1 ACTB ACTA2 ACTA1
12
Show member pathways
12.51 ACTG2 ACTG1 ACTC1 ACTB ACTA2 ACTA1
13
Show member pathways
12.48 ACTG1 ACTC1 ACTB ACTA2 ACTA1
14
Show member pathways
12.39 ACTG2 ACTG1 ACTB ACTA2
15
Show member pathways
12.36 ACTG2 ACTG1 ACTC1 ACTB ACTA2 ACTA1
16
Show member pathways
12.35 ACTG2 ACTG1 ACTB ACTA2 ACTA1
17
Show member pathways
12.35 ACTG2 ACTG1 ACTB ACTA2 ACTA1
18 12.35 KRT5 ACTG2 ACTG1 ACTC1 ACTB ACTA2
19
Show member pathways
12.34 ACTG2 ACTG1 ACTB ACTA2 ACTA1
20
Show member pathways
12.32 ACTG2 ACTG1 ACTC1 ACTB ACTA2 ACTA1
21
Show member pathways
12.31 ACTG2 ACTG1 ACTB ACTA2 ACTA1
22
Show member pathways
12.11 ACTG1 ACTC1 ACTB
23
Show member pathways
12.1 ACTG1 ACTB ACTA1
24
Show member pathways
12.06 ACTG2 ACTG1 ACTB
25 12 ACTG2 ACTG1 ACTB ACTA2 ACTA1
26
Show member pathways
11.95 ACTG2 ACTG1 ACTB ACTA2 ACTA1
27 11.93 ACTG2 ACTG1 ACTB ACTA2 ACTA1
28
Show member pathways
11.91 KRT5 KRT14 ACTG1 ACTB
29 11.71 ACTG1 ACTC1 ACTA2 ACTA1
30 11.67 ACTG2 ACTG1 ACTB ACTA2 ACTA1
31 11.52 ACTG2 ACTG1 ACTB ACTA2 ACTA1
32 11.43 ACTG2 ACTG1 ACTC1 ACTB ACTA2 ACTA1
33 11.34 ACTG2 ACTG1 ACTB ACTA2 ACTA1
34 11.18 ACTG1 ACTB
35 10.99 ACTG2 ACTG1 ACTB ACTA2 ACTA1
36 10.7 ACTG2 ACTG1 ACTC1 ACTB ACTA2 ACTA1
37 10.63 ACTG2 ACTG1 ACTB ACTA2 ACTA1

GO Terms for Breast Myoepithelial Carcinoma

Cellular components related to Breast Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 10.17 WAPL PGR KRT5 KRT14 ARG1 ACTG2
2 extracellular exosome GO:0070062 10.08 KRT5 KRT14 ACTG2 ACTG1 ACTC1 ACTB
3 extracellular space GO:0005615 10.01 SERPINB5 ARG1 ACTG2 ACTG1 ACTC1 ACTB
4 cytoskeleton GO:0005856 9.99 ACTG2 ACTG1 ACTC1 ACTB ACTA2 ACTA1
5 cytoplasm GO:0005737 9.97 WAPL SERPINB5 PGR KRT5 KRT14 EZH2
6 lamellipodium GO:0030027 9.76 ACTG2 ACTC1 ACTA2 ACTA1
7 cell body GO:0044297 9.67 ACTG2 ACTC1 ACTA2 ACTA1
8 actin filament GO:0005884 9.62 ACTG1 ACTC1 ACTB ACTA1
9 filopodium GO:0030175 9.56 ACTG2 ACTC1 ACTA2 ACTA1
10 calyx of Held GO:0044305 9.52 ACTG1 ACTB
11 dense body GO:0097433 9.49 ACTG1 ACTB
12 blood microparticle GO:0072562 9.35 ACTG2 ACTG1 ACTC1 ACTB ACTA1
13 actin cytoskeleton GO:0015629 9.1 ACTG2 ACTG1 ACTC1 ACTB ACTA2 ACTA1

Biological processes related to Breast Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.76 ACTG2 ACTC1 ACTA2 ACTA1
2 muscle contraction GO:0006936 9.5 ACTG2 ACTA2 ACTA1
3 response to steroid hormone GO:0048545 9.49 ARG1 ACTA1
4 response to zinc ion GO:0010043 9.48 KRT14 ARG1
5 cell junction assembly GO:0034329 9.43 ACTG1 ACTB
6 postsynaptic actin cytoskeleton organization GO:0098974 9.4 ACTG1 ACTB
7 regulation of epithelial cell proliferation GO:0050678 9.37 SERPINB5 PGR
8 protein localization to chromatin GO:0071168 9.26 WAPL EZH2
9 hemidesmosome assembly GO:0031581 9.16 KRT5 KRT14
10 skeletal muscle thin filament assembly GO:0030240 8.96 ACTC1 ACTA1
11 mesenchyme migration GO:0090131 8.92 ACTG2 ACTC1 ACTA2 ACTA1

Molecular functions related to Breast Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.63 ACTG2 ACTG1 ACTC1 ACTB ACTA2 ACTA1
2 myosin binding GO:0017022 9.26 ACTC1 ACTA1
3 structural constituent of cytoskeleton GO:0005200 9.02 KRT5 KRT14 ACTG1 ACTB ACTA1
4 structural constituent of postsynaptic actin cytoskeleton GO:0098973 8.96 ACTG1 ACTB

Sources for Breast Myoepithelial Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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