MCID: BRS029
MIFTS: 25

Breast Myoepithelial Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Breast Myoepithelial Carcinoma

MalaCards integrated aliases for Breast Myoepithelial Carcinoma:

Name: Breast Myoepithelial Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:6776
NCIt 50 C40395
UMLS 71 C1518167

Summaries for Breast Myoepithelial Carcinoma

Disease Ontology : 12 A breast carcinome that is composed entirely or almost entirely of malignant spindle cells with myoepithelial differentiation.

MalaCards based summary : Breast Myoepithelial Carcinoma is related to myoepithelial carcinoma and vulvar sarcoma. An important gene associated with Breast Myoepithelial Carcinoma is KRT14 (Keratin 14), and among its related pathways/superpathways are Phospholipase-C Pathway and Sweet Taste Signaling. Affiliated tissues include breast, and related phenotypes are growth/size/body region and craniofacial

Related Diseases for Breast Myoepithelial Carcinoma

Diseases related to Breast Myoepithelial Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 myoepithelial carcinoma 10.3 KRT14 ACTC1
2 vulvar sarcoma 10.3 ACTG2 ACTC1
3 scrotum neoplasm 10.3 ACTG2 ACTC1
4 spiradenoma 10.2 KRT14 ACTC1
5 ischemic fasciitis 10.2 KRT14 ACTC1
6 polymorphous low-grade adenocarcinoma 10.2 SERPINB5 ACTC1
7 epithelial-myoepithelial carcinoma 10.2 KRT14 ACTC1
8 oncocytic breast carcinoma 10.2 PGR KRT14
9 cervical clear cell adenocarcinoma 10.2 PGR KRT14
10 diffuse peritoneal leiomyomatosis 10.2 PGR ACTG2
11 polyp of corpus uteri 10.2 PGR KRT14
12 peritoneal benign neoplasm 10.2 PGR ACTG2
13 calcifying aponeurotic fibroma 10.2 PGR ACTC1
14 pseudosarcomatous fibromatosis 10.2 ACTG2 ACTC1
15 breast adenoma 10.2 PGR KRT14
16 adult cystic nephroma 10.2 PGR ACTC1
17 nephroma 10.1 PGR ACTC1
18 benign metastasizing leiomyoma 10.1 PGR ACTC1
19 bizarre leiomyoma 10.1 PGR ACTC1
20 myxoid leiomyosarcoma 10.1 PGR ACTC1
21 ceruminous adenocarcinoma 10.1 KRT5 KRT14
22 benign breast adenomyoepithelioma 10.1 KRT5 KRT14
23 micronodular basal cell carcinoma 10.1 KRT5 KRT14
24 squamous cell bile duct carcinoma 10.1 KRT5 KRT14
25 large cell acanthoma 10.1 KRT5 KRT14
26 epidermolysis bullosa simplex, autosomal recessive 1 10.1 KRT5 KRT14
27 odontoma 10.1 KRT5 KRT14
28 eccrine acrospiroma 10.1 KRT5 KRT14
29 eccrine sweat gland neoplasm 10.1 KRT5 KRT14
30 esophageal adenosquamous carcinoma 10.1 KRT5 KRT14
31 juvenile nasopharyngeal angiofibroma 10.1 PGR ACTC1
32 myoepithelioma 10.1 SERPINB5 KRT14 ACTC1
33 clear cell basal cell carcinoma 10.1 KRT5 KRT14
34 necrotizing sialometaplasia 10.1 KRT5 ACTC1
35 epithelioid leiomyosarcoma 10.1 PGR ACTC1
36 cystic basal cell carcinoma 10.1 KRT5 KRT14
37 epidermolysis bullosa simplex, localized 10.1 KRT5 KRT14
38 pleomorphic adenoma 10.1 SERPINB5 KRT14 ACTC1
39 pleomorphic carcinoma 10.1 PGR KRT14
40 benign peritoneal mesothelioma 10.1 KRT5 KRT14
41 adenosarcoma 10.1 PGR ACTC1
42 perivascular epithelioid cell tumor 10.1 PGR ACTC1
43 eccrine papillary adenoma 10.1 KRT5 KRT14
44 megacystis-microcolon-intestinal hypoperistalsis syndrome 10.1 ACTG2 ACTC1 ACTA2
45 prune belly syndrome 10.0 ACTG2 ACTA2
46 borst-jadassohn intraepidermal carcinoma 10.0 KRT5 KRT14
47 epidermolysis bullosa simplex, generalized 10.0 KRT5 KRT14
48 deafness, autosomal dominant 20 10.0 ACTG1 ACTA1
49 epidermolysis bullosa simplex with mottled pigmentation 10.0 KRT5 KRT14
50 glycogen-rich clear cell breast carcinoma 10.0 PGR KRT14 ACTC1

Graphical network of the top 20 diseases related to Breast Myoepithelial Carcinoma:



Diseases related to Breast Myoepithelial Carcinoma

Symptoms & Phenotypes for Breast Myoepithelial Carcinoma

MGI Mouse Phenotypes related to Breast Myoepithelial Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.56 ACTA1 ACTC1 ACTG1 ACTG2 EZH2 KRT14
2 craniofacial MP:0005382 9.55 ACTA1 ACTC1 ACTG1 KRT14 KRT5
3 muscle MP:0005369 9.1 ACTA1 ACTA2 ACTC1 ACTG1 EZH2 PGR

Drugs & Therapeutics for Breast Myoepithelial Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Myoepithelial Carcinoma

Genetic Tests for Breast Myoepithelial Carcinoma

Anatomical Context for Breast Myoepithelial Carcinoma

MalaCards organs/tissues related to Breast Myoepithelial Carcinoma:

40
Breast

Publications for Breast Myoepithelial Carcinoma

Articles related to Breast Myoepithelial Carcinoma:

# Title Authors PMID Year
1
Myoepithelial carcinoma of the breast treated with surgery and chemotherapy. 61
23984136 2013

Variations for Breast Myoepithelial Carcinoma

Expression for Breast Myoepithelial Carcinoma

Search GEO for disease gene expression data for Breast Myoepithelial Carcinoma.

Pathways for Breast Myoepithelial Carcinoma

Pathways related to Breast Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 ACTG2 ACTG1 ACTA2 ACTA1
2
Show member pathways
12.84 ACTG2 ACTG1 ACTA2 ACTA1
3
Show member pathways
12.82 ACTG2 ACTG1 ACTA2 ACTA1
4
Show member pathways
12.78 ACTG2 ACTG1 ACTA2 ACTA1
5
Show member pathways
12.75 ACTG2 ACTG1 ACTA2 ACTA1
6
Show member pathways
12.72 ACTG2 ACTG1 ACTA2 ACTA1
7
Show member pathways
12.72 ACTG2 ACTG1 ACTA2 ACTA1
8
Show member pathways
12.66 ACTG2 ACTG1 ACTA2 ACTA1
9
Show member pathways
12.5 ACTG2 ACTG1 ACTA2 ACTA1
10
Show member pathways
12.49 ACTG2 ACTG1 ACTA2 ACTA1
11
Show member pathways
12.45 ACTG2 ACTG1 ACTC1 ACTA2 ACTA1
12
Show member pathways
12.37 ACTG1 ACTC1 ACTA2 ACTA1
13
Show member pathways
12.3 ACTG2 ACTG1 ACTC1 ACTA2 ACTA1
14
Show member pathways
12.29 ACTG2 ACTG1 ACTA2
15
Show member pathways
12.26 ACTG2 ACTG1 ACTC1 ACTA2 ACTA1
16
Show member pathways
12.25 ACTG2 ACTG1 ACTA2 ACTA1
17
Show member pathways
12.25 ACTG2 ACTG1 ACTA2 ACTA1
18
Show member pathways
12.24 ACTG2 ACTG1 ACTA2 ACTA1
19 12.22 KRT5 ACTG2 ACTG1 ACTC1 ACTA2 ACTA1
20
Show member pathways
12.21 ACTG2 ACTG1 ACTA2 ACTA1
21 11.94 ACTG2 ACTG1 ACTA2 ACTA1
22
Show member pathways
11.87 ACTG2 ACTG1 ACTA2 ACTA1
23 11.83 ACTG2 ACTG1 ACTA2 ACTA1
24
Show member pathways
11.8 KRT5 KRT14 ACTG1
25 11.59 ACTG1 ACTC1 ACTA2 ACTA1
26 11.58 ACTG2 ACTG1 ACTA2 ACTA1
27 11.43 ACTG2 ACTG1 ACTA2 ACTA1
28 11.35 ACTG2 ACTG1 ACTC1 ACTA2 ACTA1
29 11.3 ACTG2 ACTG1 ACTA2 ACTA1
30 11.2 ACTG2 ACTA2
31 10.89 ACTG2 ACTG1 ACTA2 ACTA1
32 10.62 ACTG2 ACTG1 ACTC1 ACTA2 ACTA1
33 10.54 ACTG2 ACTG1 ACTA2 ACTA1

GO Terms for Breast Myoepithelial Carcinoma

Cellular components related to Breast Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 10.08 PGR KRT5 KRT14 ACTG2 ACTG1 ACTC1
2 cytoplasm GO:0005737 10.07 SERPINB5 PGR KRT5 KRT14 EZH2 ACTG2
3 extracellular exosome GO:0070062 9.95 KRT5 KRT14 ACTG2 ACTG1 ACTC1 ACTA2
4 extracellular space GO:0005615 9.93 SERPINB5 ACTG2 ACTG1 ACTC1 ACTA2 ACTA1
5 cytoskeleton GO:0005856 9.89 ACTG2 ACTG1 ACTC1 ACTA2 ACTA1
6 actin cytoskeleton GO:0015629 9.69 ACTG1 ACTA2 ACTA1
7 lamellipodium GO:0030027 9.62 ACTG2 ACTC1 ACTA2 ACTA1
8 actin filament GO:0005884 9.61 ACTG1 ACTC1 ACTA1
9 blood microparticle GO:0072562 9.56 ACTG2 ACTG1 ACTC1 ACTA1
10 cell body GO:0044297 9.46 ACTG2 ACTC1 ACTA2 ACTA1
11 filopodium GO:0030175 9.26 ACTG2 ACTC1 ACTA2 ACTA1
12 dynactin complex GO:0005869 8.92 ACTG2 ACTC1 ACTA2 ACTA1

Biological processes related to Breast Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle contraction GO:0006936 9.43 ACTG2 ACTA2 ACTA1
2 muscle filament sliding GO:0030049 9.4 ACTC1 ACTA1
3 regulation of epithelial cell proliferation GO:0050678 9.37 SERPINB5 PGR
4 positive regulation of gene expression GO:0010628 9.35 ACTG2 ACTG1 ACTC1 ACTA2 ACTA1
5 hemidesmosome assembly GO:0031581 9.32 KRT5 KRT14
6 skeletal muscle thin filament assembly GO:0030240 9.16 ACTC1 ACTA1
7 mesenchyme migration GO:0090131 8.92 ACTG2 ACTC1 ACTA2 ACTA1

Molecular functions related to Breast Myoepithelial Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.55 ACTG2 ACTG1 ACTC1 ACTA2 ACTA1
2 myosin binding GO:0017022 8.96 ACTC1 ACTA1
3 structural constituent of cytoskeleton GO:0005200 8.92 KRT5 KRT14 ACTG1 ACTA1

Sources for Breast Myoepithelial Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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