Breast Myoepithelial Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Breast Myoepithelial Neoplasm

MalaCards integrated aliases for Breast Myoepithelial Neoplasm:

Name: Breast Myoepithelial Neoplasm ¹² ¹⁵

Malignant Breast Myoepithelioma ⁷¹

Breast Myoepithelial Tumor ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3004

NCIt ⁴⁹ C40389

UMLS ⁷¹ C1511319 C1518167

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Summaries for Breast Myoepithelial Neoplasm

Disease Ontology : ¹² A breast cancer that arises from myoepithelial cells, which are a normal constituent of the salivary acini and ducts and are found between the epithelial cells and the basement membrane.

MalaCards based summary : Breast Myoepithelial Neoplasm, also known as malignant breast myoepithelioma, is related to breast adenomyoepithelioma and breast myoepitheliosis, and has symptoms including pain An important gene associated with Breast Myoepithelial Neoplasm is HSD11B2 (Hydroxysteroid 11-Beta Dehydrogenase 2), and among its related pathways/superpathways are Keratinization and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include breast, thymus and skin.

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Related Diseases for Breast Myoepithelial Neoplasm

Diseases related to Breast Myoepithelial Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)

#	Related Disease	Score	Top Affiliating Genes
1	breast adenomyoepithelioma	28.5	SERPINB5 S100P S100A3 MEG3 KRT7 KRT5
2	breast myoepitheliosis	11.4
3	pregnancy adenoma	10.3	KRT5 KRT14
4	esophageal basaloid squamous cell carcinoma	10.3	KRT5 KRT14
5	epidermolysis bullosa simplex, autosomal recessive 1	10.3	KRT5 KRT14
6	odontoma	10.3	KRT5 KRT14
7	lipid-rich carcinoma	10.3	KRT5 KRT14
8	epidermolysis bullosa simplex with mottled pigmentation	10.3	KRT5 KRT14
9	micronodular basal cell carcinoma	10.3	KRT5 KRT14
10	epidermolysis bullosa simplex, generalized	10.3	KRT5 KRT14
11	myoepithelioma	10.3	SERPINB5 KRT14
12	intraductal breast neoplasm	10.3	KRT5 KRT14
13	epidermolysis bullosa simplex, localized	10.3	KRT5 KRT14
14	intracystic papillary adenoma	10.3	KRT5 KRT14
15	reticulate acropigmentation of kitamura	10.2	KRT5 KRT14
16	intraductal papilloma	10.2	KRT5 KRT14
17	hard palate cancer	10.2	KRT5 KRT14
18	vesiculobullous skin disease	10.2	KRT5 KRT14
19	sebaceous adenocarcinoma	10.2	KRT5 KRT14
20	epidermolysis bullosa simplex, dowling-meara type	10.2	KRT5 KRT14
21	pachyonychia congenita 1	10.1	KRT5 KRT14
22	palmoplantar keratoderma, epidermolytic	10.1	KRT5 KRT14
23	luminal breast carcinoma	10.1	KRT5 KRT14
24	dowling-degos disease	10.1	KRT5 KRT14
25	breast myoepithelial carcinoma	10.0	SERPINB5 KRT5 KRT14
26	inverted transitional papilloma	10.0	KRT7 KRT5
27	malignant spiradenoma	10.0	KRT7 KRT5
28	ceruminoma	10.0	KRT7 KRT5
29	ureter adenocarcinoma	10.0	KRT7 KRT5
30	subareolar duct papillomatosis	10.0	KRT7 KRT5
31	bone leiomyosarcoma	10.0	KRT7 KRT5
32	nipple neoplasm	10.0	KRT7 KRT5
33	microinvasive cervical squamous cell carcinoma	10.0	KRT7 KRT5
34	skin benign neoplasm	10.0	KRT5 KRT14
35	myoepithelial carcinoma	10.0	KRT7 KRT14
36	external ear carcinoma	10.0	KRT7 KRT5
37	vulvar apocrine adenocarcinoma	10.0	KRT7 KRT5
38	gastric squamous cell carcinoma	10.0	KRT7 KRT5
39	middle ear adenoma	10.0	KRT7 KRT5
40	eccrine papillary adenocarcinoma	10.0	KRT7 KRT5
41	necrotizing sialometaplasia	10.0	KRT7 KRT5
42	sensory organ benign neoplasm	10.0	KRT7 KRT5
43	bile duct mucoepidermoid carcinoma	10.0	KRT7 KRT5
44	breast mucinous carcinoma	10.0	KRT7 KRT5
45	spiradenoma	10.0	KRT7 KRT14
46	clear cell hidradenoma	10.0	KRT7 KRT5
47	hidradenoma	10.0	KRT7 KRT5
48	eccrine sweat gland cancer	10.0	KRT7 KRT5
49	sweat gland cancer	10.0	KRT7 KRT5
50	middle ear adenocarcinoma	10.0	KRT7 KRT5

Graphical network of the top 20 diseases related to Breast Myoepithelial Neoplasm:

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Symptoms & Phenotypes for Breast Myoepithelial Neoplasm

UMLS symptoms related to Breast Myoepithelial Neoplasm:

pain

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Drugs & Therapeutics for Breast Myoepithelial Neoplasm

Search Clinical Trials , NIH Clinical Center for Breast Myoepithelial Neoplasm

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Genetic Tests for Breast Myoepithelial Neoplasm

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Anatomical Context for Breast Myoepithelial Neoplasm

MalaCards organs/tissues related to Breast Myoepithelial Neoplasm:

⁴⁰

Breast, Thymus, Skin, Bone, Heart, Lung, Salivary Gland

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Publications for Breast Myoepithelial Neoplasm

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Genes for Breast Myoepithelial Neoplasm

Genes related to Breast Myoepithelial Neoplasm (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HSD11B2	Hydroxysteroid 11-Beta Dehydrogenase 2	Protein Coding	7.58	DISEASES inferred ¹⁵
2	KRT5	Keratin 5	Protein Coding	6.47	DISEASES inferred ¹⁵
3	KRT14	Keratin 14	Protein Coding	6.07	DISEASES inferred ¹⁵
4	ADM5	Adrenomedullin 5 (Putative)	Protein Coding	5.9	DISEASES inferred ¹⁵
5	SERPINB5	Serpin Family B Member 5	Protein Coding	5.75	DISEASES inferred ¹⁵
6	S100A3	S100 Calcium Binding Protein A3	Protein Coding	5.74	DISEASES inferred ¹⁵
7	S100P	S100 Calcium Binding Protein P	Protein Coding	5.61	DISEASES inferred ¹⁵
8	KRT7	Keratin 7	Protein Coding	5.19	DISEASES inferred ¹⁵
9	MEG3	Maternally Expressed 3	RNA Gene	5.15	DISEASES inferred ¹⁵

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Variations for Breast Myoepithelial Neoplasm

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Expression for Breast Myoepithelial Neoplasm

Search GEO for disease gene expression data for Breast Myoepithelial Neoplasm.

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Pathways for Breast Myoepithelial Neoplasm

Pathways related to Breast Myoepithelial Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Keratinization ⁶⁵ Show member pathways Formation of the cornified envelope ⁶⁵	11.59	KRT7 KRT5 KRT14
2	Cytoskeleton remodeling Neurofilaments ²² Show member pathways Cytoskeleton remodeling Keratin filaments ²²	10.83	KRT7 KRT5 KRT14

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GO Terms for Breast Myoepithelial Neoplasm

Cellular components related to Breast Myoepithelial Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:0005882	9.13	KRT7 KRT5 KRT14
2	keratin filament	GO:0045095	8.8	KRT7 KRT5 KRT14

Biological processes related to Breast Myoepithelial Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	keratinization	GO:0031424	9.33	KRT7 KRT5 KRT14
2	hemidesmosome assembly	GO:0031581	8.96	KRT5 KRT14
3	cornification	GO:0070268	8.8	KRT7 KRT5 KRT14

Molecular functions related to Breast Myoepithelial Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transition metal ion binding	GO:0046914	8.62	S100P S100A3

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Sources for Breast Myoepithelial Neoplasm

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⁶⁹ TGDB

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⁷⁴ Wikipedia