MCID: BRS058
MIFTS: 30

Breast Myoepithelial Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Breast Myoepithelial Neoplasm

MalaCards integrated aliases for Breast Myoepithelial Neoplasm:

Name: Breast Myoepithelial Neoplasm 12 15
Malignant Breast Myoepithelioma 74
Breast Myoepithelial Tumor 74

Classifications:



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Disease Ontology 12 DOID:3004
NCIt 51 C40389

Summaries for Breast Myoepithelial Neoplasm

Disease Ontology : 12 A breast cancer that arises from myoepithelial cells, which are a normal constituent of the salivary acini and ducts and are found between the epithelial cells and the basement membrane.

MalaCards based summary : Breast Myoepithelial Neoplasm, also known as malignant breast myoepithelioma, is related to breast adenomyoepithelioma and breast myoepitheliosis, and has symptoms including pain An important gene associated with Breast Myoepithelial Neoplasm is HSD11B2 (Hydroxysteroid 11-Beta Dehydrogenase 2), and among its related pathways/superpathways are Ras signaling pathway and Cell surface interactions at the vascular wall. Affiliated tissues include breast, and related phenotypes are G0/1 arrest and cellular

Related Diseases for Breast Myoepithelial Neoplasm

Diseases related to Breast Myoepithelial Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 breast adenomyoepithelioma 28.1 ACIN1 CD99 CDH1 CEACAM5 ENO2 HSD11B2
2 breast myoepitheliosis 11.3
3 lichen planopilaris 10.4 KRT14 KRT5
4 epidermolysis bullosa simplex, autosomal recessive 1 10.4 KRT14 KRT5
5 epidermolysis bullosa simplex, localized 10.4 KRT14 KRT5
6 epidermolysis bullosa simplex, generalized 10.4 KRT14 KRT5
7 breast cystic hypersecretory carcinoma 10.4 CDH1 KRT5
8 epidermolysis bullosa simplex with mottled pigmentation 10.4 KRT14 KRT5
9 spiradenoma 10.4 KRT14 KRT7
10 thyroid hurthle cell adenoma 10.3 KRT14 PIK3CA
11 inverted transitional papilloma 10.3 KRT5 KRT7
12 ceruminoma 10.3 KRT5 KRT7
13 benign mesothelioma 10.3 KRT5 KRT7
14 oncocytic breast carcinoma 10.3 KRT14 KRT7
15 odontoma 10.3 KRT14 KRT5
16 malignant acrospiroma 10.3 CEACAM5 KRT5
17 cervical adenoma malignum 10.3 KRT7 MME
18 breast benign neoplasm 10.3 KRT14 KRT5 MME
19 thoracic benign neoplasm 10.3 KRT14 KRT5 MME
20 hidradenoma 10.3 KRT7 PIK3CA
21 cervical mucinous adenocarcinoma 10.3 KRT7 MME
22 fibroepithelial basal cell carcinoma 10.2 CEACAM5 KRT14
23 clear cell papillary renal cell carcinoma 10.2 KRT7 MME
24 cervix endometriosis 10.2 CEACAM5 MME
25 large intestine adenocarcinoma 10.2 CDH1 KRT7
26 lipid-rich carcinoma 10.2 CDH1 KRT14 KRT5
27 linitis plastica 10.2 CDH1 KRT7
28 renal pelvis adenocarcinoma 10.2 CDH1 KRT7
29 malignant leydig cell tumor 10.2 KRT7 MME
30 pre-malignant neoplasm 10.2 CDH1 KRT14 KRT5
31 in situ carcinoma 10.2 CDH1 KRT14 KRT5
32 adenoid squamous cell carcinoma 10.2 CDH1 KRT7
33 ductal carcinoma in situ 10.2 CDH1 KRT14 KRT5
34 breast squamous cell carcinoma 10.2 KRT14 KRT5 PIK3CA
35 brooke-spiegler syndrome 10.2 KRT14 KRT7
36 bladder lymphoma 10.2 KRT7 MME
37 benign breast adenomyoepithelioma 10.2 KRT14 KRT5 KRT7
38 adenomyoma 10.2 KRT7 MME
39 large cell acanthoma 10.2 KRT14 KRT5 KRT7
40 apocrine sweat gland neoplasm 10.2 KRT14 KRT5 KRT7
41 gastric diffuse adenocarcinoma 10.2 CDH1 KRT7
42 squamous cell carcinoma of the oral tongue 10.2 CDH1 PIK3CA
43 apocrine adenoma 10.2 CEACAM5 PIK3CA
44 sweat gland disease 10.2 KRT14 KRT5 KRT7
45 intraneural perineurioma 10.2 KRT14 KRT5 KRT7
46 goblet cell carcinoid 10.2 CDH1 ENO2
47 primary cutaneous amyloidosis 10.2 KRT14 KRT5 KRT7
48 cutaneous mucoepidermoid carcinoma 10.2 CEACAM5 KRT7
49 clear cell adenoma 10.2 CEACAM5 KITLG
50 balloon cell malignant melanoma 10.2 KRT5 KRT7 MME

Graphical network of the top 20 diseases related to Breast Myoepithelial Neoplasm:



Diseases related to Breast Myoepithelial Neoplasm

Symptoms & Phenotypes for Breast Myoepithelial Neoplasm

UMLS symptoms related to Breast Myoepithelial Neoplasm:


pain

GenomeRNAi Phenotypes related to Breast Myoepithelial Neoplasm according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 G0/1 arrest GR00098-A-2 9.02 ACIN1 CD99 CDH1 HSD11B2 KRT7

MGI Mouse Phenotypes related to Breast Myoepithelial Neoplasm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.61 CDH1 ENO2 HSD11B2 KITLG KRT14 KRT7
2 neoplasm MP:0002006 9.1 CDH1 HSD11B2 KITLG KRT14 PIK3CA PIK3R1

Drugs & Therapeutics for Breast Myoepithelial Neoplasm

Search Clinical Trials , NIH Clinical Center for Breast Myoepithelial Neoplasm

Genetic Tests for Breast Myoepithelial Neoplasm

Anatomical Context for Breast Myoepithelial Neoplasm

MalaCards organs/tissues related to Breast Myoepithelial Neoplasm:

42
Breast

Publications for Breast Myoepithelial Neoplasm

Variations for Breast Myoepithelial Neoplasm

Expression for Breast Myoepithelial Neoplasm

Search GEO for disease gene expression data for Breast Myoepithelial Neoplasm.

Pathways for Breast Myoepithelial Neoplasm

Pathways related to Breast Myoepithelial Neoplasm according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.54 CDH1 KITLG PIK3CA PIK3R1
2
Show member pathways
11.96 CD99 CEACAM5 PIK3CA PIK3R1
3
Show member pathways
11.84 CDH1 KITLG PIK3CA PIK3R1
4 11.75 CEACAM5 KITLG MME
5
Show member pathways
11.69 KRT14 KRT5 KRT7
6 11.63 ENO2 PIK3CA PIK3R1
7 11.48 CDH1 PIK3CA PIK3R1
8 11.22 CDH1 PIK3CA PIK3R1
9 11.07 HSD11B2 PIK3CA PIK3R1
10 10.95 PIK3CA PIK3R1
11 10.95 PIK3CA PIK3R1
12 10.95 CDH1 PIK3CA PIK3R1
13 10.92 PIK3CA PIK3R1
14 10.91 PIK3CA PIK3R1
15 10.82 CDH1 PIK3CA PIK3R1
16 10.81 PIK3CA PIK3R1
17 10.8 PIK3CA PIK3R1
18 10.77 PIK3CA PIK3R1
19 10.64 PIK3CA PIK3R1
20 10.53 CDH1 PIK3CA PIK3R1
21 10.08 CDH1 PIK3CA PIK3R1

GO Terms for Breast Myoepithelial Neoplasm

Cellular components related to Breast Myoepithelial Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.96 ACIN1 CD99 CDH1 CEACAM5 ENO2 KITLG
2 extracellular exosome GO:0070062 9.91 CDH1 CEACAM5 ENO2 KRT14 KRT5 KRT7
3 cytoplasm GO:0005737 9.73 CD99 CDH1 ENO2 HSD11B2 KITLG KRT14
4 keratin filament GO:0045095 9.33 KRT14 KRT5 KRT7
5 phosphatidylinositol 3-kinase complex GO:0005942 9.32 PIK3CA PIK3R1
6 phosphatidylinositol 3-kinase complex, class IA GO:0005943 8.62 PIK3CA PIK3R1

Biological processes related to Breast Myoepithelial Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol phosphorylation GO:0046854 9.33 KITLG PIK3CA PIK3R1
2 negative regulation of anoikis GO:2000811 9.26 CEACAM5 PIK3CA
3 cornification GO:0070268 9.13 KRT14 KRT5 KRT7
4 hemidesmosome assembly GO:0031581 8.62 KRT14 KRT5

Molecular functions related to Breast Myoepithelial Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor substrate binding GO:0043560 8.96 PIK3CA PIK3R1
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.8 KITLG PIK3CA PIK3R1

Sources for Breast Myoepithelial Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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