Breast Myoepithelial Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Breast Myoepithelial Neoplasm

MalaCards integrated aliases for Breast Myoepithelial Neoplasm:

Name: Breast Myoepithelial Neoplasm ¹² ¹⁵

Malignant Breast Myoepithelioma ⁷⁴

Breast Myoepithelial Tumor ⁷⁴

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3004

NCIt ⁵¹ C40389

UMLS ⁷⁴ C1511319 C1518167

Sources

Summaries for Breast Myoepithelial Neoplasm

Disease Ontology : ¹² A breast cancer that arises from myoepithelial cells, which are a normal constituent of the salivary acini and ducts and are found between the epithelial cells and the basement membrane.

MalaCards based summary : Breast Myoepithelial Neoplasm, also known as malignant breast myoepithelioma, is related to breast adenomyoepithelioma and breast myoepitheliosis, and has symptoms including pain An important gene associated with Breast Myoepithelial Neoplasm is HSD11B2 (Hydroxysteroid 11-Beta Dehydrogenase 2), and among its related pathways/superpathways are Ras signaling pathway and Cell surface interactions at the vascular wall. Affiliated tissues include breast, and related phenotypes are G0/1 arrest and cellular

Sources

Related Diseases for Breast Myoepithelial Neoplasm

Diseases related to Breast Myoepithelial Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)

#	Related Disease	Score	Top Affiliating Genes
1	breast adenomyoepithelioma	28.1	ACIN1 CD99 CDH1 CEACAM5 ENO2 HSD11B2
2	breast myoepitheliosis	11.3
3	lichen planopilaris	10.4	KRT14 KRT5
4	epidermolysis bullosa simplex, autosomal recessive 1	10.4	KRT14 KRT5
5	epidermolysis bullosa simplex, localized	10.4	KRT14 KRT5
6	epidermolysis bullosa simplex, generalized	10.4	KRT14 KRT5
7	breast cystic hypersecretory carcinoma	10.4	CDH1 KRT5
8	epidermolysis bullosa simplex with mottled pigmentation	10.4	KRT14 KRT5
9	spiradenoma	10.4	KRT14 KRT7
10	thyroid hurthle cell adenoma	10.3	KRT14 PIK3CA
11	inverted transitional papilloma	10.3	KRT5 KRT7
12	ceruminoma	10.3	KRT5 KRT7
13	benign mesothelioma	10.3	KRT5 KRT7
14	oncocytic breast carcinoma	10.3	KRT14 KRT7
15	odontoma	10.3	KRT14 KRT5
16	malignant acrospiroma	10.3	CEACAM5 KRT5
17	cervical adenoma malignum	10.3	KRT7 MME
18	breast benign neoplasm	10.3	KRT14 KRT5 MME
19	thoracic benign neoplasm	10.3	KRT14 KRT5 MME
20	hidradenoma	10.3	KRT7 PIK3CA
21	cervical mucinous adenocarcinoma	10.3	KRT7 MME
22	fibroepithelial basal cell carcinoma	10.2	CEACAM5 KRT14
23	clear cell papillary renal cell carcinoma	10.2	KRT7 MME
24	cervix endometriosis	10.2	CEACAM5 MME
25	large intestine adenocarcinoma	10.2	CDH1 KRT7
26	lipid-rich carcinoma	10.2	CDH1 KRT14 KRT5
27	linitis plastica	10.2	CDH1 KRT7
28	renal pelvis adenocarcinoma	10.2	CDH1 KRT7
29	malignant leydig cell tumor	10.2	KRT7 MME
30	pre-malignant neoplasm	10.2	CDH1 KRT14 KRT5
31	in situ carcinoma	10.2	CDH1 KRT14 KRT5
32	adenoid squamous cell carcinoma	10.2	CDH1 KRT7
33	ductal carcinoma in situ	10.2	CDH1 KRT14 KRT5
34	breast squamous cell carcinoma	10.2	KRT14 KRT5 PIK3CA
35	brooke-spiegler syndrome	10.2	KRT14 KRT7
36	bladder lymphoma	10.2	KRT7 MME
37	benign breast adenomyoepithelioma	10.2	KRT14 KRT5 KRT7
38	adenomyoma	10.2	KRT7 MME
39	large cell acanthoma	10.2	KRT14 KRT5 KRT7
40	apocrine sweat gland neoplasm	10.2	KRT14 KRT5 KRT7
41	gastric diffuse adenocarcinoma	10.2	CDH1 KRT7
42	squamous cell carcinoma of the oral tongue	10.2	CDH1 PIK3CA
43	apocrine adenoma	10.2	CEACAM5 PIK3CA
44	sweat gland disease	10.2	KRT14 KRT5 KRT7
45	intraneural perineurioma	10.2	KRT14 KRT5 KRT7
46	goblet cell carcinoid	10.2	CDH1 ENO2
47	primary cutaneous amyloidosis	10.2	KRT14 KRT5 KRT7
48	cutaneous mucoepidermoid carcinoma	10.2	CEACAM5 KRT7
49	clear cell adenoma	10.2	CEACAM5 KITLG
50	balloon cell malignant melanoma	10.2	KRT5 KRT7 MME

Graphical network of the top 20 diseases related to Breast Myoepithelial Neoplasm:

Sources

Symptoms & Phenotypes for Breast Myoepithelial Neoplasm

UMLS symptoms related to Breast Myoepithelial Neoplasm:

pain

GenomeRNAi Phenotypes related to Breast Myoepithelial Neoplasm according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	G0/1 arrest	GR00098-A-2	9.02	ACIN1 CD99 CDH1 HSD11B2 KRT7

MGI Mouse Phenotypes related to Breast Myoepithelial Neoplasm:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	9.61	CDH1 ENO2 HSD11B2 KITLG KRT14 KRT7
2	neoplasm	MP:0002006	9.1	CDH1 HSD11B2 KITLG KRT14 PIK3CA PIK3R1

Sources

Drugs & Therapeutics for Breast Myoepithelial Neoplasm

Search Clinical Trials , NIH Clinical Center for Breast Myoepithelial Neoplasm

Sources

Genetic Tests for Breast Myoepithelial Neoplasm

Sources

Anatomical Context for Breast Myoepithelial Neoplasm

MalaCards organs/tissues related to Breast Myoepithelial Neoplasm:

⁴²

Breast

Sources

Publications for Breast Myoepithelial Neoplasm

Sources

Genes for Breast Myoepithelial Neoplasm

Genes related to Breast Myoepithelial Neoplasm (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HSD11B2	Hydroxysteroid 11-Beta Dehydrogenase 2	Protein Coding	16.89	DISEASES inferred ¹⁵
2	KRT5	Keratin 5	Protein Coding	15.73	DISEASES inferred ¹⁵
3	KRT14	Keratin 14	Protein Coding	14.93	DISEASES inferred ¹⁵
4	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	14.36	DISEASES inferred ¹⁵
5	SERPINB5	Serpin Family B Member 5	Protein Coding	14.15	DISEASES inferred ¹⁵
6	MME	Membrane Metalloendopeptidase	Protein Coding	14	DISEASES inferred ¹⁵
7	KITLG	KIT Ligand	Protein Coding	13.62	DISEASES inferred ¹⁵
8	CDH1	Cadherin 1	Protein Coding	13.45	DISEASES inferred ¹⁵
9	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	13.25	DISEASES inferred ¹⁵
10	KRT7	Keratin 7	Protein Coding	13.19	DISEASES inferred ¹⁵
11	ENO2	Enolase 2	Protein Coding	13.01	DISEASES inferred ¹⁵
12	ACIN1	Apoptotic Chromatin Condensation Inducer 1	Protein Coding	6.15	DISEASES inferred ¹⁵
13	CD99	CD99 Molecule (Xg Blood Group)	Protein Coding	4.46	DISEASES inferred ¹⁵
14	CEACAM5	Carcinoembryonic Antigen Related Cell Adhesion Molecule 5	Protein Coding	3.5	DISEASES inferred ¹⁵

Sources

Variations for Breast Myoepithelial Neoplasm

Sources

Expression for Breast Myoepithelial Neoplasm

Search GEO for disease gene expression data for Breast Myoepithelial Neoplasm.

Sources

Pathways for Breast Myoepithelial Neoplasm

Pathways related to Breast Myoepithelial Neoplasm according to GeneCards Suite gene sharing:

(show all 21)

#	Super pathways	Score	Top Affiliating Genes
1	Ras signaling pathway ³⁸ Show member pathways Rap1 signaling pathway ³⁸	12.54	CDH1 KITLG PIK3CA PIK3R1
2	Cell surface interactions at the vascular wall ⁶⁷ Show member pathways Fibronectin matrix formation ⁶⁷ PECAM1 interactions ⁶⁷ Tie2 Signaling ⁶⁷	11.96	CD99 CEACAM5 PIK3CA PIK3R1
3	Immune response IFN gamma signaling pathway ²³ Show member pathways IFN-gamma pathway ¹	11.84	CDH1 KITLG PIK3CA PIK3R1
4	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	11.75	CEACAM5 KITLG MME
5	Cytoskeleton remodeling Neurofilaments ²³ Show member pathways Cytoskeleton remodeling Keratin filaments ²³	11.69	KRT14 KRT5 KRT7
6	HIF-1 signaling pathway ³⁸	11.63	ENO2 PIK3CA PIK3R1
7	Bacterial invasion of epithelial cells ³⁸	11.48	CDH1 PIK3CA PIK3R1
8	FGF signaling pathway ¹	11.22	CDH1 PIK3CA PIK3R1
9	Aldosterone-regulated sodium reabsorption ³⁸	11.07	HSD11B2 PIK3CA PIK3R1
10	Cytoskeleton remodeling_Role of PDGFs in cell migration ²³	10.95	PIK3CA PIK3R1
11	VEGFR3 signaling in lymphatic endothelium ¹	10.95	PIK3CA PIK3R1
12	E-cadherin signaling in the nascent adherens junction ¹	10.95	CDH1 PIK3CA PIK3R1
13	Nephrin interactions ⁶⁷	10.92	PIK3CA PIK3R1
14	PDGFR-alpha signaling pathway ¹	10.91	PIK3CA PIK3R1
15	a6b1 and a6b4 Integrin signaling ¹	10.82	CDH1 PIK3CA PIK3R1
16	Nongenotropic Androgen signaling ¹	10.81	PIK3CA PIK3R1
17	Regulation of signaling by CBL ⁶⁷	10.8	PIK3CA PIK3R1
18	EPHA2 forward signaling ¹	10.77	PIK3CA PIK3R1
19	Atypical NF-kappaB pathway ¹	10.64	PIK3CA PIK3R1
20	Nectin adhesion pathway ¹	10.53	CDH1 PIK3CA PIK3R1
21	E-cadherin signaling in keratinocytes ¹	10.08	CDH1 PIK3CA PIK3R1

Sources

GO Terms for Breast Myoepithelial Neoplasm

Cellular components related to Breast Myoepithelial Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.96	ACIN1 CD99 CDH1 CEACAM5 ENO2 KITLG
2	extracellular exosome	GO:0070062	9.91	CDH1 CEACAM5 ENO2 KRT14 KRT5 KRT7
3	cytoplasm	GO:0005737	9.73	CD99 CDH1 ENO2 HSD11B2 KITLG KRT14
4	keratin filament	GO:0045095	9.33	KRT14 KRT5 KRT7
5	phosphatidylinositol 3-kinase complex	GO:0005942	9.32	PIK3CA PIK3R1
6	phosphatidylinositol 3-kinase complex, class IA	GO:0005943	8.62	PIK3CA PIK3R1

Biological processes related to Breast Myoepithelial Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	phosphatidylinositol phosphorylation	GO:0046854	9.33	KITLG PIK3CA PIK3R1
2	negative regulation of anoikis	GO:2000811	9.26	CEACAM5 PIK3CA
3	cornification	GO:0070268	9.13	KRT14 KRT5 KRT7
4	hemidesmosome assembly	GO:0031581	8.62	KRT14 KRT5

Molecular functions related to Breast Myoepithelial Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	insulin receptor substrate binding	GO:0043560	8.96	PIK3CA PIK3R1
2	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934	8.8	KITLG PIK3CA PIK3R1

Sources

Sources for Breast Myoepithelial Neoplasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia