MCID: BRS005
MIFTS: 31

Breast Neuroendocrine Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Breast Neuroendocrine Neoplasm

MalaCards integrated aliases for Breast Neuroendocrine Neoplasm:

Name: Breast Neuroendocrine Neoplasm 12 15 70
Neuroendocrine Tumor of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3009
NCIt 50 C5169
UMLS 70 C1332635

Summaries for Breast Neuroendocrine Neoplasm

Disease Ontology : 12 A breast benign neoplasm that forms from cells that release hormones into the blood in response to a signal from the nervous system.

MalaCards based summary : Breast Neuroendocrine Neoplasm, also known as neuroendocrine tumor of the breast, is related to carcinoid syndrome and neuroendocrine tumor. An important gene associated with Breast Neuroendocrine Neoplasm is SYP (Synaptophysin), and among its related pathways/superpathways are Gastric cancer and Signaling by ERBB4. Affiliated tissues include breast, lung and ovary, and related phenotypes are cellular and endocrine/exocrine gland

Related Diseases for Breast Neuroendocrine Neoplasm

Diseases related to Breast Neuroendocrine Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 494)
# Related Disease Score Top Affiliating Genes
1 carcinoid syndrome 30.5 SYP ENO2 CHGA
2 neuroendocrine tumor 30.1 SYP NCAM1 KRT20 ENO2 CHGA CDX2
3 neuroendocrine carcinoma 28.9 SYP NCAM1 KRT7 KRT20 ENO2 CHGA
4 malignant melanocytic neoplasm of the peripheral nerve sheath 10.4 SYP ENO2
5 optic nerve astrocytoma 10.4 SYP ENO2
6 cerebral neuroblastoma 10.4 SYP ENO2
7 neuronal intestinal dysplasia, type b 10.4 SYP ENO2
8 sinonasal undifferentiated carcinoma 10.4 SYP ENO2
9 papillary tumor of the pineal region 10.4 SYP ENO2
10 primary hepatic neuroendocrine carcinoma 10.4 SYP CHGA
11 cloacogenic carcinoma 10.4 SYP ENO2
12 pineal region teratoma 10.4 SYP ENO2
13 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.4 SYP ENO2
14 intracranial primitive neuroectodermal tumor 10.4 SYP ENO2
15 bile duct mucinous adenocarcinoma 10.4 SYP ENO2
16 nodular prostate 10.4 SYP ENO2
17 acinar cell cystadenocarcinoma 10.4 SYP CHGA
18 cerebellar liponeurocytoma 10.4 SYP ENO2
19 gastrointestinal neuroendocrine benign tumor 10.4 SYP CHGA
20 mixed ductal-endocrine carcinoma 10.4 SYP CHGA
21 frontal lobe neoplasm 10.4 SYP ENO2
22 gastric gastrinoma 10.4 ENO2 CHGA
23 duodenal benign neoplasm 10.4 SYP CHGA
24 bartholin's duct cyst 10.4 PIP GATA3
25 myoblastoma 10.4 SYP ENO2
26 gastric neuroendocrine neoplasm 10.4 SYP CHGA
27 pineal parenchymal tumor of intermediate differentiation 10.4 SYP ENO2
28 subungual glomus tumor 10.4 SYP PIP
29 nodular ganglioneuroblastoma 10.4 ENO2 CHGA
30 ewing sarcoma of bone 10.4 ENO2 CHGA
31 kidney rhabdoid cancer 10.4 SYP ENO2
32 spinal cord oligodendroglioma 10.4 SYP ENO2
33 pancreatic gastrinoma 10.4 SYP CHGA
34 appendix lymphoma 10.4 ENO2 CHGA
35 papillary adenoma 10.4 SYP KRT7
36 endobronchial leiomyoma 10.4 SYP ENO2
37 vulva basal cell carcinoma 10.4 SYP ERBB2
38 small cell osteogenic sarcoma 10.4 SYP ENO2
39 binswanger's disease 10.3 SYP CHGA
40 rhabdoid meningioma 10.3 SYP ENO2
41 pancreatic acinar cell adenocarcinoma 10.3 SYP CHGA
42 laryngeal mucoepidermoid carcinoma 10.3 ERBB2 CDX2
43 ceruminoma 10.3 PIP KRT7
44 cerebellum cancer 10.3 SYP ENO2
45 extra-adrenal pheochromocytoma 10.3 SYP CHGA
46 vulvar eccrine porocarcinoma 10.3 SYP PIP CHGA
47 congenital epulis 10.3 PGR ENO2
48 epulis 10.3 PGR ENO2
49 malignant acrospiroma 10.3 PIP KRT7
50 auditory system cancer 10.3 SYP ENO2 CHGA

Graphical network of the top 20 diseases related to Breast Neuroendocrine Neoplasm:



Diseases related to Breast Neuroendocrine Neoplasm

Symptoms & Phenotypes for Breast Neuroendocrine Neoplasm

MGI Mouse Phenotypes related to Breast Neuroendocrine Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.15 CDH1 CDX2 ENO2 ERBB2 ESR1 GATA3
2 endocrine/exocrine gland MP:0005379 9.91 CDH1 CDX2 CHGA ERBB2 ESR1 GATA3
3 digestive/alimentary MP:0005381 9.87 CDH1 CDX2 ERBB2 ESR1 GATA3 ISL1
4 neoplasm MP:0002006 9.63 CDH1 CDX2 ERBB2 ESR1 ISL1 PGR
5 normal MP:0002873 9.56 CDH1 CDX2 ERBB2 ESR1 GATA3 ISL1
6 reproductive system MP:0005389 9.32 B3GAT1 CDH1 CDX2 CHGA ERBB2 ESR1

Drugs & Therapeutics for Breast Neuroendocrine Neoplasm

Search Clinical Trials , NIH Clinical Center for Breast Neuroendocrine Neoplasm

Genetic Tests for Breast Neuroendocrine Neoplasm

Anatomical Context for Breast Neuroendocrine Neoplasm

MalaCards organs/tissues related to Breast Neuroendocrine Neoplasm:

40
Breast, Lung, Ovary, Appendix, Colon, Pineal, Kidney

Publications for Breast Neuroendocrine Neoplasm

Articles related to Breast Neuroendocrine Neoplasm:

(show all 18)
# Title Authors PMID Year
1
Fine needle aspiration cytology of primary neuroendocrine tumor of the breast and it's differential diagnosis. 61
33048455 2021
2
Primary neuroendocrine carcinoma of the breast: a 5-year experiences. 61
32180568 2020
3
Primary neuroendocrine carcinoma of the breast: a 5-year experiences. 61
31541545 2019
4
Well-differentiated neuroendocrine tumor of the breast with extensive lymphatic and vascular infiltration. 61
27862661 2016
5
[Primary large cell neuroendocrine carcinoma of the breast: a rare tumor in humans]. 61
28292162 2016
6
HER-2 positive primary solid neuroendocrine carcinoma of the breast: a case report and review of the literature. 61
22711316 2015
7
Primary neuroendocrine tumor of the breast. 61
25808825 2015
8
Breast metastasis as the first clinical manifestation of ileal neuroendocrine tumor. A challenging diagnosis with relevant clinical implications. 61
25935445 2015
9
Well-differentiated neuroendocrine tumor of the breast with recurrence due to needle tract seeding. 61
25560191 2015
10
[Neuroendocrine tumor of the breast--metastasis or primary breast carcinoma? Case report]. 61
26421954 2015
11
68Ga DOTANOC PET/CT in primary neuroendocrine tumor of the breast. 61
24566407 2014
12
Primary neuroendocrine tumor of the breast: imaging features. 61
23690703 2013
13
Primary large-cell neuroendocrine tumor of the breast. 61
23458218 2013
14
A rare case report of a primary large-cell neuroendocrine carcinoma of the breast with coexisting Paget disease. 61
22920370 2012
15
Small cell neuroendocrine tumor of the breast in a 40 year-old woman: a case report. 61
20591162 2010
16
Multinodular cutaneous spread in neuroendocrine tumor of the breast : an unusual presentation. 61
18039021 2007
17
Neuroendocrine tumor of the breast. 61
16536254 2006
18
Primary neuroendocrine tumor of the breast. 61
9330271 1997

Variations for Breast Neuroendocrine Neoplasm

Expression for Breast Neuroendocrine Neoplasm

Search GEO for disease gene expression data for Breast Neuroendocrine Neoplasm.

Pathways for Breast Neuroendocrine Neoplasm

Pathways related to Breast Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.69 PGR ESR1 ERBB2 CDX2 CDH1
2
Show member pathways
11.47 PGR ESR1 ERBB2
3 11.23 SYP NCAM1 ISL1
4 10.91 GATA3 CDX2 CDH1

GO Terms for Breast Neuroendocrine Neoplasm

Biological processes related to Breast Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pharyngeal system development GO:0060037 9.32 ISL1 GATA3
2 uterus development GO:0060065 9.26 GATA3 ESR1
3 cardiac right ventricle morphogenesis GO:0003215 9.16 ISL1 GATA3
4 intracellular steroid hormone receptor signaling pathway GO:0030518 8.96 PGR ESR1
5 positive regulation of cell differentiation GO:0045597 8.8 ISL1 GATA3 CDX2

Molecular functions related to Breast Neuroendocrine Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.35 PGR ISL1 GATA3 ESR1 CDX2
2 identical protein binding GO:0042802 9.23 SYP PIP PGR NCAM1 GATA3 ESR1

Sources for Breast Neuroendocrine Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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