MCID: BRS030
MIFTS: 31

Breast Osteosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Breast Osteosarcoma

MalaCards integrated aliases for Breast Osteosarcoma:

Name: Breast Osteosarcoma 12 15
Breast Extraskeletal Osteosarcoma 71
Osteogenic Sarcoma of Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7787
NCIt 49 C5189
UMLS 71 C1335149

Summaries for Breast Osteosarcoma

Disease Ontology : 12 A breast sarcoma that arises from bone.

MalaCards based summary : Breast Osteosarcoma, also known as breast extraskeletal osteosarcoma, is related to breast sarcoma and breast fibroadenoma, and has symptoms including pain An important gene associated with Breast Osteosarcoma is OSGEP (O-Sialoglycoprotein Endopeptidase), and among its related pathways/superpathways are Keratinization and Cytoskeletal Signaling. Affiliated tissues include breast, bone and lung, and related phenotypes are immune system and integument

Related Diseases for Breast Osteosarcoma

Diseases related to Breast Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 416)
# Related Disease Score Top Affiliating Genes
1 breast sarcoma 30.3 PGR MME ESR1 ERBB2
2 breast fibroadenoma 29.9 PGR MME KRT8 ESR1 ERBB2
3 dysgerminoma 29.8 WT1 KRT7 KRT20
4 proliferating trichilemmal cyst 10.6 KRT8 KRT7
5 endolymphatic sac tumor 10.6 KRT8 KRT7
6 inverted transitional papilloma 10.6 KRT7 KRT5
7 malignant spiradenoma 10.6 KRT7 KRT5
8 ceruminoma 10.6 KRT7 KRT5
9 breast cystic hypersecretory carcinoma 10.6 KRT5 ERBB2
10 ureter adenocarcinoma 10.6 KRT7 KRT5
11 benign breast adenomyoepithelioma 10.6 KRT7 KRT5
12 breast adenomyoepithelioma 10.6 KRT7 KRT5
13 vulval paget's disease 10.6 KRT7 ERBB2
14 bone leiomyosarcoma 10.5 KRT7 KRT5
15 vulva basal cell carcinoma 10.5 KRT5 ERBB2
16 mucinous adenofibroma 10.5 KRT7 ESR1
17 ceruminous adenocarcinoma 10.5 KRT7 KRT5
18 fat necrosis of breast 10.5 ESR1 CAGE1
19 submandibular gland cancer 10.5 KRT7 ERBB2
20 gastric squamous cell carcinoma 10.5 KRT7 KRT5
21 breast myofibroblastoma 10.5 MME ESR1
22 middle ear adenoma 10.5 KRT7 KRT5
23 wolffian duct adenoma 10.5 MME KRT7
24 breast myoepithelial neoplasm 10.5 KRT7 KRT5
25 intrahepatic gall duct cancer 10.5 KRT8 KRT7
26 mixed epithelial stromal tumour 10.5 MME KRT7
27 necrotizing sialometaplasia 10.5 KRT7 KRT5
28 sensory organ benign neoplasm 10.5 KRT7 KRT5
29 urethral villous adenoma 10.5 KRT7 KRT20
30 cervix erosion 10.5 MME KRT5
31 odontoma 10.5 KRT8 KRT5
32 cervical adenoma malignum 10.5 MME KRT7
33 bile duct mucoepidermoid carcinoma 10.5 KRT7 KRT5
34 pancreatic serous cystadenocarcinoma 10.5 KRT7 KRT20
35 intrahepatic bile duct adenoma 10.5 KRT7 KRT20
36 hidrocystoma 10.5 KRT8 KRT7
37 seminal vesicle adenocarcinoma 10.5 KRT7 KRT20
38 clear cell papillary renal cell carcinoma 10.5 MME KRT7
39 thymus lipoma 10.5 KRT8 KRT20
40 gastric signet ring cell adenocarcinoma 10.5 KRT7 KRT20
41 immune system organ benign neoplasm 10.5 KRT8 KRT20
42 chromophil adenoma of the kidney 10.5 MME KRT7
43 ovarian large-cell neuroendocrine carcinoma 10.5 KRT7 KRT20
44 adenoid basal cell carcinoma 10.5 SPN KRT7
45 small cell carcinoma of the bladder 10.5 KRT7 KRT20
46 aortic malignant tumor 10.5 KRT7 KRT20
47 urinary bladder small cell neuroendocrine carcinoma 10.5 KRT7 KRT20
48 urinary bladder villous adenoma 10.5 KRT7 KRT20
49 middle ear adenocarcinoma 10.5 KRT7 KRT5
50 nonmucinous bronchioloalveolar adenocarcinoma 10.5 KRT20 ESR1

Graphical network of the top 20 diseases related to Breast Osteosarcoma:



Diseases related to Breast Osteosarcoma

Symptoms & Phenotypes for Breast Osteosarcoma

UMLS symptoms related to Breast Osteosarcoma:


pain

MGI Mouse Phenotypes related to Breast Osteosarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.07 BCL6 CD5 CD79A ESR1 FLNA KRT8
2 integument MP:0010771 9.92 BCL6 CD5 ERBB2 ESR1 KRT5 MME
3 liver/biliary system MP:0005370 9.8 BCL6 CD79A ESR1 FLNA KRT8 MME
4 neoplasm MP:0002006 9.63 CD79A ERBB2 ESR1 PGR SPN WT1
5 no phenotypic analysis MP:0003012 9.56 BCL6 CD5 CD79A ESR1 KRT5 MYOG
6 normal MP:0002873 9.32 BCL6 CD2 CD5 CD79A ERBB2 ESR1

Drugs & Therapeutics for Breast Osteosarcoma

Search Clinical Trials , NIH Clinical Center for Breast Osteosarcoma

Genetic Tests for Breast Osteosarcoma

Anatomical Context for Breast Osteosarcoma

MalaCards organs/tissues related to Breast Osteosarcoma:

40
Breast, Bone, Lung, Thymus, B Cells, Colon, Liver

Publications for Breast Osteosarcoma

Articles related to Breast Osteosarcoma:

(show all 19)
# Title Authors PMID Year
1
Primary Osteosarcoma of the Breast: Pathophysiology and Imaging Review. 61
30655112 2020
2
Diagnostic evaluation and treatment of primary breast osteosarcoma: A case report. 61
31077474 2019
3
Primary breast osteosarcoma mimicking calcified fibroadenoma on screening digital breast tomosynthesis mammogram. 61
29484041 2017
4
[Breast osteosarcoma originating in a phyllodes tumor. Report of one case]. 61
29189868 2017
5
Evolution and prognosis of breast osteosarcoma: A case report. 61
26870284 2016
6
Primary breast osteosarcoma: A diagnostic challenge. 61
25589804 2015
7
Primary breast osteosarcoma: a case report and review of literature. 61
25210125 2014
8
Breast osteosarcoma 29 years after radiation therapy for epithelial breast cancer. 61
23904847 2013
9
Primary breast osteosarcoma: dynamic contrast-enhanced magnetic resonance imaging, proton spectroscopy and diffusion weighted imaging findings. 61
23138146 2012
10
Breast mass with intense 99mTc-diphosphonate uptake revealing primary breast osteosarcoma. 61
21383295 2011
11
Synchronize primary breast osteosarcoma and contralateral benign cystosarcoma phylloides: radiologic and pathologic imaging. 61
18186876 2008
12
Primary osteogenic sarcoma of breast detected on Tc-99m MIBI scintigraphy and Tc-99m MDP skeletal scintigraphy. 61
18250991 2008
13
Primary osteosarcoma of the breast: report of 2 cases. 61
17488168 2007
14
Primary mammary osteogenic sarcoma. 61
17290347 2007
15
[Breast osteosarcoma]. 61
11879623 2002
16
[Breast osteosarcoma. Review of the literature and presentation of two cases]. 61
2068486 1991
17
[Breast osteosarcoma coexistent with an adenocarcinoma]. 61
6574562 1983
18
[Primary breast osteosarcoma]. 61
283681 1978
19
[Osteogenic sarcoma of breast in the x-ray picture]. 61
280022 1978

Variations for Breast Osteosarcoma

Expression for Breast Osteosarcoma

Search GEO for disease gene expression data for Breast Osteosarcoma.

Pathways for Breast Osteosarcoma

Pathways related to Breast Osteosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.08 KRT8 KRT7 KRT5 KRT20
2 12.04 KRT8 KRT7 KRT5 KRT20 FLNA
3
Show member pathways
11.64 PGR ESR1 ERBB2
4
Show member pathways
11.61 KRT8 KRT7 KRT5
5 11.54 MME CD5 CD2
6 11.3 WT1 MME KRT8
7 11.09 SPN MME CD79A CD5 CD2
8 10.98 SPN MME CD5 BCL6

GO Terms for Breast Osteosarcoma

Cellular components related to Breast Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.13 KRT8 KRT7 KRT5
2 intermediate filament GO:0005882 8.92 KRT8 KRT7 KRT5 KRT20

Biological processes related to Breast Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.26 KRT8 KRT7 KRT5 KRT20
2 cornification GO:0070268 8.92 KRT8 KRT7 KRT5 KRT20

Molecular functions related to Breast Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.55 WT1 PGR OSGEP MYOG MME KRT8
2 transmembrane signaling receptor activity GO:0004888 9.26 SPN ERBB2 CD79A CD5

Sources for Breast Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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