MCID: BRS060
MIFTS: 36

Breast Papillomatosis

Categories: Cancer diseases

Aliases & Classifications for Breast Papillomatosis

MalaCards integrated aliases for Breast Papillomatosis:

Name: Breast Papillomatosis 12 15 70
Papillomatosis of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1634
NCIt 50 C6977
UMLS 70 C1332636

Summaries for Breast Papillomatosis

Disease Ontology : 12 A breast benign neoplasm that is characterized by papillary proliferations within multiple terminal duct-lobular units or in the distal branches (terminal ducts) of the duct system.

MalaCards based summary : Breast Papillomatosis, also known as papillomatosis of the breast, is related to breast intraductal papillomatosis and breast juvenile papillomatosis. An important gene associated with Breast Papillomatosis is TOX4 (TOX High Mobility Group Box Family Member 4), and among its related pathways/superpathways are Signaling by GPCR and Akt Signaling. Affiliated tissues include breast, lung and thyroid, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 73 Papillomatosis of the breasts is a proliferative epithelial lesion (epitheliosis) of the breast.... more...

Related Diseases for Breast Papillomatosis

Diseases in the Breast Papillomatosis family:

Breast Juvenile Papillomatosis

Diseases related to Breast Papillomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
# Related Disease Score Top Affiliating Genes
1 breast intraductal papillomatosis 32.1 PGR ERBB2
2 breast juvenile papillomatosis 30.6 PIK3CA OXT GNAS FGFR3 ERBB2 AKT1
3 hypertrophy of breast 30.2 PIK3CA PGR ERBB2
4 breast fibroadenoma 29.9 TIMP2 PGR ERBB2
5 papilloma 29.5 FGFR3 ERBB2 CDKN2A CCND1 AKT1
6 in situ carcinoma 29.5 PIK3CA PGR ERBB2 CDKN2A CCND1 AKT1
7 parotid gland adenoid cystic carcinoma 10.4 ERBB2 CDKN2A
8 vulva basal cell carcinoma 10.4 ERBB2 CDKN2A
9 epiglottis neoplasm 10.3 PIK3CA CCND1
10 penile benign neoplasm 10.3 PIK3CA CDKN2A
11 bowenoid papulosis 10.3 CDKN2A CCND1
12 esophagus verrucous carcinoma 10.3 CDKN2A CCND1
13 ovarian carcinosarcoma 10.3 PIK3CA ERBB2
14 localized osteosarcoma 10.3 ERBB2 CDKN2A
15 glassy cell carcinoma of the cervix 10.3 PGR ERBB2
16 nipple carcinoma 10.3 PGR ERBB2
17 scirrhous adenocarcinoma 10.3 PGR ERBB2
18 lipid-rich breast carcinoma 10.3 PGR ERBB2
19 tonsil squamous cell carcinoma 10.3 CDKN2A CCND1
20 breast scirrhous carcinoma 10.3 PGR ERBB2
21 oncocytic breast carcinoma 10.3 PGR ERBB2
22 frontal convexity meningioma 10.3 PIK3CA GNAS
23 apocrine adenosis of breast 10.3 PGR ERBB2
24 breast papillary carcinoma 10.3 PGR ERBB2
25 luminal breast carcinoma b 10.3 PGR ERBB2
26 comedo carcinoma 10.3 PGR ERBB2
27 breast adenoid cystic carcinoma 10.3 PGR ERBB2
28 endometrial squamous cell carcinoma 10.3 PGR CDKN2A
29 breast metaplastic carcinoma 10.3 PGR ERBB2
30 breast mucinous carcinoma 10.3 PGR ERBB2
31 gastric diffuse adenocarcinoma 10.3 PGR ERBB2
32 malignant exocrine pancreas neoplasm 10.3 GNAS CDKN2A
33 vulvar disease 10.2 PIK3CA ERBB2 CDKN2A
34 ovarian seromucinous carcinoma 10.2 PGR CDKN2A
35 endometrial mucinous adenocarcinoma 10.2 PGR CDKN2A
36 lipid-rich carcinoma 10.2 PGR ERBB2
37 linitis plastica 10.2 PGR ERBB2
38 ethmoid sinus adenocarcinoma 10.2 PIK3CA ERBB2 CCND1
39 breast sarcoma 10.2 PGR ERBB2
40 meningioma, radiation-induced 10.2 PIK3CA AKT1
41 breast malignant phyllodes tumor 10.2 PGR ERBB2
42 vulva cancer 10.2 PIK3CA ERBB2 CDKN2A
43 intracranial meningioma 10.2 PGR CDKN2A
44 progesterone-receptor negative breast cancer 10.2 PGR ERBB2
45 bizarre leiomyoma 10.2 PGR CDKN2A
46 squamous cell papilloma 10.2
47 breast disease 10.2
48 fallopian tube endometrioid adenocarcinoma 10.2 ERBB2 CDKN2A
49 intracystic papillary adenoma 10.2 PGR ERBB2
50 triple-receptor negative breast cancer 10.2 PGR ERBB2

Graphical network of the top 20 diseases related to Breast Papillomatosis:



Diseases related to Breast Papillomatosis

Symptoms & Phenotypes for Breast Papillomatosis

GenomeRNAi Phenotypes related to Breast Papillomatosis according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 10.09 PIK3CA
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 10.09 ERBB2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-157 10.09 PIK3CA
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-16 10.09 AKT1 PIK3CA
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-163 10.09 ERBB2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-166 10.09 PIK3CA
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 10.09 AKT1 PIK3CA
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-190 10.09 PIK3CA
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10.09 PIK3CA
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-42 10.09 AKT1 PIK3CA
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-49 10.09 PIK3CA
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-50 10.09 AKT1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 10.09 PIK3CA
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 10.09 AKT1
15 Decreased viability GR00221-A-1 9.8 AKT1 CDKN2A FGFR3
16 Decreased viability GR00221-A-2 9.8 AKT1 FGFR3
17 Decreased viability GR00221-A-3 9.8 AKT1 CDKN2A ERBB2 FGFR3
18 Decreased viability GR00221-A-4 9.8 AKT1 CDKN2A ERBB2
19 Decreased viability GR00249-S 9.8 AKT1 FGFR3
20 Decreased cell migration GR00055-A-1 9.56 AKT1 FGFR3 TIMP2
21 Decreased cell migration GR00055-A-3 9.56 PIK3CA
22 Reduced mammosphere formation GR00396-S 9.17 A2M AKT1S1 CCND1 GNAS MMP14 PLK1

MGI Mouse Phenotypes related to Breast Papillomatosis:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.4 AKT1 CCND1 CDKN2A ERBB2 FGFR3 GNAS
2 growth/size/body region MP:0005378 10.34 AKT1 CCND1 CDKN2A ERBB2 FGFR3 GNAS
3 homeostasis/metabolism MP:0005376 10.34 A2M AKT1 AKT1S1 CCND1 CDKN2A ERBB2
4 cardiovascular system MP:0005385 10.32 AKT1 CCND1 CDKN2A ERBB2 GNAS MMP14
5 cellular MP:0005384 10.32 AKT1 CCND1 CDKN2A ERBB2 FGFR3 GNAS
6 mortality/aging MP:0010768 10.25 AKT1 CCND1 CDKN2A ERBB2 FGFR3 GNAS
7 endocrine/exocrine gland MP:0005379 10.24 AKT1 CCND1 CDKN2A ERBB2 GNAS MMP14
8 immune system MP:0005387 10.22 AKT1 CCND1 CDKN2A FGFR3 GNAS MMP14
9 hematopoietic system MP:0005397 10.21 AKT1 CCND1 CDKN2A FGFR3 GNAS MMP14
10 embryo MP:0005380 10.2 AKT1 CDKN2A ERBB2 MMP14 PGR PIK3CA
11 integument MP:0010771 10.16 AKT1 CCND1 CDKN2A ERBB2 FGFR3 GNAS
12 nervous system MP:0003631 10.13 AKT1 AKT1S1 CCND1 CDKN2A ERBB2 FGFR3
13 craniofacial MP:0005382 10.11 CCND1 ERBB2 FGFR3 GNAS MMP14 TOX4
14 digestive/alimentary MP:0005381 10.1 CCND1 CDKN2A ERBB2 FGFR3 MMP14 OXT
15 neoplasm MP:0002006 10.02 AKT1 CCND1 CDKN2A ERBB2 FGFR3 GNAS
16 muscle MP:0005369 9.95 AKT1 CDKN2A ERBB2 GNAS MMP14 PGR
17 normal MP:0002873 9.86 AKT1 CCND1 ERBB2 FGFR3 GNAS MMP14
18 reproductive system MP:0005389 9.81 AKT1 CCND1 CDKN2A ERBB2 FGFR3 MMP14
19 respiratory system MP:0005388 9.56 AKT1 CCND1 CDKN2A ERBB2 FGFR3 GNAS
20 skeleton MP:0005390 9.32 AKT1 CCND1 CDKN2A ERBB2 FGFR3 GNAS

Drugs & Therapeutics for Breast Papillomatosis

Search Clinical Trials , NIH Clinical Center for Breast Papillomatosis

Genetic Tests for Breast Papillomatosis

Anatomical Context for Breast Papillomatosis

MalaCards organs/tissues related to Breast Papillomatosis:

40
Breast, Lung, Thyroid, Skin, Ovary, Cervix, Tonsil

Publications for Breast Papillomatosis

Articles related to Breast Papillomatosis:

(show all 42)
# Title Authors PMID Year
1
Juvenile Papillomatosis in a Young Child: A Case of Infantile Bloody Nipple Discharge. 61
32717364 2020
2
Juvenile papillomatosis of the breast (Swiss cheese disease) has frequent associations with PIK3CA and/or AKT1 mutations. 61
32088208 2020
3
Gingival Papillomatosis as the Oral Sign of Cowden Syndrome: A Case Report. 61
31969239 2019
4
Juvenile Papillomatosis: A Case Report. 61
31001616 2019
5
Giant juvenile papillomatosis of the breast in a Nigerian girl. 61
30567257 2018
6
Juvenile Papillomatosis of the Breast in a Pre-Pubertal Girl: An Uncommon Diagnosis. 61
29322120 2018
7
Juvenile Papillomatosis (Swiss-Cheese Disease) of Breast in an Adult Male With Sequential Diagnoses of Ipsilateral Intraductal, Invasive, and Widely Metastatic Carcinoma: A Case Report and Review of the Disease in Males. 61
28420303 2017
8
Magnetic resonance imaging findings of breast juvenile papillomatosis. 61
23475601 2013
9
Juvenile papillomatosis of the breast in young male: a case report. 61
22018260 2011
10
Juvenile papillomatosis of the breast associated with neurofibromatosis 1. 61
16883593 2007
11
[Juvenille papillomatosis]. 61
16484940 2006
12
Juvenile papillomatosis of the breast in a male infant with Noonan syndrome, café au lait spots, and family history of breast carcinoma. 61
15700254 2005
13
[The clinical significance of the expression of four cell cycle regulators in breast papillomotosis]. 61
14642081 2003
14
[Juvenile papillomatosis of the breast]. 61
12870277 2003
15
Juvenile papillomatosis of the breast in a 9-year-old girl. 61
11315290 2001
16
A case of breast cancer associated with juvenile papillomatosis of the male breast. 61
11078621 2000
17
Juvenile papillomatosis of the breast in male infants: two case reports. 61
10663852 2000
18
[Breast malignancy in girls]. 61
10462972 1999
19
A Case of Multiple Juvenile Papillomatosis of the Breast and Its Immunohistochemical Pathology. 61
11091647 1998
20
[Immunohistochemical study of c-erbB-2 and p53 protein in breast papillomatosis and its malignant transformation]. 61
10920912 1997
21
Juvenile papillomatosis of the breast (Swiss cheese disease) 61
9275926 1997
22
[Pathological study of en bloc breast sections in papillomatosis and its malignant transformation]. 61
11038762 1997
23
Giant juvenile papillomatosis of the breast: report of two cases. 61
9185400 1997
24
Case report: MR imaging of juvenile papillomatosis of the breast. 61
8983594 1996
25
Intraduct papillomatosis of the breast in a peripubertal male. 61
7971575 1994
26
Juvenile papillomatosis of the breast. 61
8103370 1993
27
Juvenile papillomatosis of the breast. A multidisciplinary study. 61
2014142 1991
28
Juvenile papillomatosis of the breast. A follow-up study of 41 patients having biopsies before 1979. 61
2158224 1990
29
The continuing evolution of our understanding of juvenile papillomatosis of the breast. 61
2158228 1990
30
Juvenile papillomatosis of the breast: sonographic appearance. 61
3055027 1988
31
[Intraductal juvenile papillomatosis of the breast]. 61
3617975 1987
32
[Intraductal papillomatosis of the breast in a female infant]. 61
3705784 1986
33
Three-dimensional atypical structure in intraductal carcinoma differentiating from papilloma and papillomatosis of the breast. 61
2983798 1985
34
[Papillomas and papillomatosis of the breast: clinical, diagnostic and therapeutic implications]. 61
6545142 1984
35
Extensive squamous metaplasia simulating squamous cell carcinoma in benign breast papillomatosis. 61
6642498 1983
36
[Intraductal papillomatosis of the breast--a report of 23 cases]. 61
6872837 1983
37
Juvenile papillomatosis of the breast and family history of breast carcinoma. 61
7074576 1982
38
Juvenile papillomatosis (Swiss cheese disease) of the breast. 61
7361994 1980
39
Extreme duct papillomatosis of the juvenile breast. 61
230701 1979
40
[Atypical papillomatosis of the breast]. 61
620643 1978
41
Intraductal papillomatosis of the breast. Report of a case in a ten-year-old girl. 61
5936652 1966
42
BREAST PAPILLOMATOSIS. 61
14252363 1964

Variations for Breast Papillomatosis

Expression for Breast Papillomatosis

Search GEO for disease gene expression data for Breast Papillomatosis.

Pathways for Breast Papillomatosis

Pathways related to Breast Papillomatosis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.13 PLK1 PIK3CA PGR OXT GNAS FGFR3
2
Show member pathways
13.37 TIMP2 GNAS FGFR3 ERBB2 CCND1 AKT1S1
3
Show member pathways
13.24 TIMP2 GNAS FGFR3 ERBB2 AKT1S1 AKT1
4
Show member pathways
12.93 PIK3CA GNAS FGFR3 ERBB2 CCND1 AKT1
5
Show member pathways
12.91 PIK3CA GNAS CDKN2A CCND1 AKT1
6
Show member pathways
12.83 PIK3CA GNAS FGFR3 ERBB2 AKT1
7
Show member pathways
12.76 PIK3CA ERBB2 CDKN2A CCND1 AKT1
8
Show member pathways
12.68 PIK3CA FGFR3 ERBB2 AKT1S1 AKT1
9
Show member pathways
12.6 PIK3CA PGR ERBB2 CDKN2A CCND1 AKT1
10
Show member pathways
12.46 PIK3CA CCND1 AKT1S1 AKT1
11
Show member pathways
12.45 PIK3CA ERBB2 CCND1 AKT1
12 12.44 PIK3CA FGFR3 ERBB2 CDKN2A CCND1
13
Show member pathways
12.41 PIK3CA FGFR3 ERBB2 AKT1
14
Show member pathways
12.39 PIK3CA FGFR3 AKT1S1 AKT1
15
Show member pathways
12.39 PIK3CA FGFR3 ERBB2 AKT1S1 AKT1
16
Show member pathways
12.37 PIK3CA FGFR3 ERBB2 CCND1 AKT1
17
Show member pathways
12.35 PLK1 PIK3CA PGR AKT1
18
Show member pathways
12.34 PIK3CA GNAS ERBB2 CDKN2A CCND1 AKT1
19 12.31 PIK3CA CDKN2A CCND1 AKT1
20 12.3 PIK3CA OXT GNAS AKT1
21
Show member pathways
12.28 PIK3CA ERBB2 CCND1 AKT1
22 12.27 PIK3CA ERBB2 CCND1 AKT1
23 12.22 PIK3CA GNAS FGFR3 ERBB2 CDKN2A CCND1
24
Show member pathways
12.16 PIK3CA GNAS CCND1 AKT1
25
Show member pathways
12.16 PIK3CA GNAS ERBB2 CCND1 AKT1
26 12.15 MMP14 GNAS CCND1 AKT1
27 12.12 PIK3CA CDKN2A CCND1 AKT1
28
Show member pathways
12.09 PIK3CA GNAS ERBB2 AKT1
29 12.04 PIK3CA PGR GNAS AKT1
30
Show member pathways
12.03 PLK1 PIK3CA CCND1 AKT1
31 12.01 PIK3CA GNAS AKT1
32
Show member pathways
12 PIK3CA GNAS AKT1
33
Show member pathways
12 PIK3CA ERBB2 AKT1
34 11.99 PIK3CA CCND1 AKT1
35 11.95 PIK3CA MMP14 AKT1
36 11.95 CDKN2A CCND1 AKT1
37 11.94 PIK3CA ERBB2 AKT1
38
Show member pathways
11.93 PIK3CA PGR ERBB2
39
Show member pathways
11.93 PLK1 CDKN2A CCND1
40 11.92 MMP14 CDKN2A AKT1S1
41 11.89 PIK3CA CCND1 AKT1
42
Show member pathways
11.88 TIMP2 MMP14 A2M
43 11.85 PIK3CA CCND1 AKT1
44 11.84 PIK3CA AKT1S1 AKT1
45
Show member pathways
11.82 PIK3CA FGFR3 ERBB2 CCND1 AKT1S1 AKT1
46
Show member pathways
11.81 PIK3CA AKT1 A2M
47 11.71 TIMP2 GNAS FGFR3 ERBB2
48 11.69 PIK3CA GNAS AKT1
49 11.68 PIK3CA CCND1 AKT1
50 11.67 PIK3CA ERBB2 AKT1

GO Terms for Breast Papillomatosis

Cellular components related to Breast Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.36 PLK1 PIK3CA PGR MMP14 GNAS ERBB2

Biological processes related to Breast Papillomatosis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.85 PLK1 PIK3CA FGFR3 ERBB2 CDKN2A AKT1
2 positive regulation of MAPK cascade GO:0043410 9.76 TIMP2 FGFR3 ERBB2
3 negative regulation of protein kinase activity GO:0006469 9.71 CDKN2A AKT1S1 AKT1
4 response to organic substance GO:0010033 9.69 TIMP2 CCND1 AKT1
5 positive regulation of cell growth GO:0030307 9.67 MMP14 ERBB2 AKT1
6 extracellular matrix disassembly GO:0022617 9.63 TIMP2 MMP14 A2M
7 response to hormone GO:0009725 9.61 TIMP2 MMP14 AKT1
8 cellular response to prostaglandin E stimulus GO:0071380 9.58 GNAS AKT1
9 apoptotic mitochondrial changes GO:0008637 9.57 CDKN2A AKT1
10 negative regulation of macroautophagy GO:0016242 9.56 PIK3CA AKT1
11 chondrocyte proliferation GO:0035988 9.55 MMP14 FGFR3
12 anoikis GO:0043276 9.52 PIK3CA AKT1
13 phosphatidylinositol 3-kinase signaling GO:0014065 9.5 PIK3CA ERBB2 AKT1
14 negative regulation of cell size GO:0045792 9.48 AKT1S1 AKT1
15 protein phosphorylation GO:0006468 9.43 PLK1 PIK3CA FGFR3 ERBB2 CCND1 AKT1
16 negative regulation of immature T cell proliferation in thymus GO:0033088 9.4 ERBB2 CDKN2A
17 positive regulation of protein localization to nucleus GO:1900182 9.33 PLK1 CDKN2A AKT1
18 response to UV-A GO:0070141 9.26 CCND1 AKT1
19 endochondral ossification GO:0001958 8.8 MMP14 GNAS FGFR3

Molecular functions related to Breast Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.06 TWSG1 TOX4 TIMP2 PLK1 PIK3CA PGR
2 protein kinase activity GO:0004672 9.35 PLK1 FGFR3 ERBB2 CCND1 AKT1
3 kinase activity GO:0016301 9.17 PLK1 PIK3CA FGFR3 ERBB2 CDKN2A CCND1

Sources for Breast Papillomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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