MCID: BRS020
MIFTS: 22

Breast Pericanalicular Fibroadenoma

Categories: Cancer diseases

Aliases & Classifications for Breast Pericanalicular Fibroadenoma

MalaCards integrated aliases for Breast Pericanalicular Fibroadenoma:

Name: Breast Pericanalicular Fibroadenoma 12 15
Pericanalicular Fibroadenoma 12 71
Pericanalicular Fibroadenoma of Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2639
NCIt 49 C4272
SNOMED-CT 67 41382006
UMLS 71 C0334497

Summaries for Breast Pericanalicular Fibroadenoma

Disease Ontology : 12 A breast fibroadenoma that is characterized by stromal proliferation around epithelial structures.

MalaCards based summary : Breast Pericanalicular Fibroadenoma, also known as pericanalicular fibroadenoma, is related to breast fibroadenoma and coffin-siris syndrome 2. An important gene associated with Breast Pericanalicular Fibroadenoma is EXTL2 (Exostosin Like Glycosyltransferase 2), and among its related pathways/superpathways are Metabolism and Glycosaminoglycan metabolism. Affiliated tissues include breast, and related phenotypes are Decreased shRNA abundance and Reduced mammosphere formation

Related Diseases for Breast Pericanalicular Fibroadenoma

Diseases related to Breast Pericanalicular Fibroadenoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 breast fibroadenoma 10.5
2 coffin-siris syndrome 2 9.7 CSGALNACT1 CHSY1 CHPF
3 temtamy preaxial brachydactyly syndrome 9.7 CSGALNACT1 CHSY1 CHPF
4 coffin-siris syndrome 3 9.6 CSGALNACT1 CHSY1 CHPF
5 coffin-siris syndrome 1 9.6 CSGALNACT1 CHSY1 CHPF
6 autosomal dominant non-syndromic intellectual disability 9.5 CSGALNACT1 CHSY1 CHPF
7 hereditary multiple exostoses 9.5 EXTL2 EXT2
8 exostosis 9.4 EXTL2 EXT2

Graphical network of the top 20 diseases related to Breast Pericanalicular Fibroadenoma:



Diseases related to Breast Pericanalicular Fibroadenoma

Symptoms & Phenotypes for Breast Pericanalicular Fibroadenoma

GenomeRNAi Phenotypes related to Breast Pericanalicular Fibroadenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00297-A 9.13 CHST12 CHSY1 EXTL2
2 Reduced mammosphere formation GR00396-S 8.92 CHPF CHST12 CHST7 EXTL2

Drugs & Therapeutics for Breast Pericanalicular Fibroadenoma

Search Clinical Trials , NIH Clinical Center for Breast Pericanalicular Fibroadenoma

Genetic Tests for Breast Pericanalicular Fibroadenoma

Anatomical Context for Breast Pericanalicular Fibroadenoma

MalaCards organs/tissues related to Breast Pericanalicular Fibroadenoma:

40
Breast

Publications for Breast Pericanalicular Fibroadenoma

Articles related to Breast Pericanalicular Fibroadenoma:

# Title Authors PMID Year
1
Quantitative analysis of mast cells in benign and malignant breast lesions. Immunohistochemical study on formalin-fixed, paraffin-embedded tissues. 61
15178888 2004
2
Giant fibroadenoma of the breast. 61
12751688 2002
3
[Functional morphology of breast APUD cells in dysplasia and neoplastic processes]. 61
2565714 1989
4
Variation in glycosaminoglycan components of breast tumors. 61
179697 1976
5
[Cystosarcoma phyllodes in an adolescent girl with intra- and pericanalicular fibroadenoma of the contralateral breast]. 61
189660 1976
6
[An unusual case of bilateral mammary pericanalicular fibroadenoma in a male, cured after treatment with methyltestosterone hexvlenol ether]. 61
14024381 1962

Variations for Breast Pericanalicular Fibroadenoma

Expression for Breast Pericanalicular Fibroadenoma

Search GEO for disease gene expression data for Breast Pericanalicular Fibroadenoma.

Pathways for Breast Pericanalicular Fibroadenoma

Pathways related to Breast Pericanalicular Fibroadenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.41 HS3ST6 EXTL2 EXT2 CSGALNACT1 CHSY1 CHST7
2
Show member pathways
11.92 HS3ST6 EXT2 CSGALNACT1 CHSY1 CHST7 CHST12
3
Show member pathways
11.86 CSGALNACT1 CHSY1 CHST7 CHST12 CHPF
4
Show member pathways
11.09 EXTL2 EXT2

GO Terms for Breast Pericanalicular Fibroadenoma

Cellular components related to Breast Pericanalicular Fibroadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.92 HS3ST6 EXTL2 EXT2 CSGALNACT1 CHSY1 CHST7
2 integral component of membrane GO:0016021 9.86 HS3ST6 EXTL2 EXT2 CSGALNACT1 CHSY1 CHST7
3 Golgi apparatus GO:0005794 9.5 HS3ST6 EXT2 CSGALNACT1 CHSY1 CHST7 CHST12
4 integral component of Golgi membrane GO:0030173 9.37 CSGALNACT1 CHST12
5 Golgi cisterna membrane GO:0032580 9.33 CSGALNACT1 CHSY1 CHPF
6 Golgi membrane GO:0000139 9.17 HS3ST6 EXT2 CSGALNACT1 CHSY1 CHST7 CHST12

Biological processes related to Breast Pericanalicular Fibroadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cartilage development GO:0051216 9.43 CSGALNACT1 CHSY1
2 glycosaminoglycan biosynthetic process GO:0006024 9.4 HS3ST6 EXT2
3 proteoglycan biosynthetic process GO:0030166 9.37 CSGALNACT1 CHST12
4 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.32 EXTL2 EXT2
5 N-acetylglucosamine metabolic process GO:0006044 9.26 EXTL2 CHST7
6 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 9.16 EXT2 CSGALNACT1
7 chondroitin sulfate biosynthetic process GO:0030206 9.02 CSGALNACT1 CHSY1 CHST7 CHST12 CHPF
8 UDP-N-acetylgalactosamine metabolic process GO:0019276 8.96 EXTL2 CSGALNACT1

Molecular functions related to Breast Pericanalicular Fibroadenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring glycosyl groups GO:0016757 9.67 EXTL2 EXT2 CHSY1 CHPF
2 transferase activity GO:0016740 9.56 HS3ST6 EXTL2 EXT2 CSGALNACT1 CHSY1 CHST7
3 glucuronosyltransferase activity GO:0015020 9.43 EXT2 CSGALNACT1
4 sulfotransferase activity GO:0008146 9.43 HS3ST6 CHST7 CHST12
5 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity GO:0050510 9.4 CHSY1 CHPF
6 acetylgalactosaminyltransferase activity GO:0008376 9.33 CSGALNACT1 CHSY1 CHPF
7 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity GO:0047237 9.32 EXTL2 CSGALNACT1
8 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity GO:0047238 8.8 CSGALNACT1 CHSY1 CHPF

Sources for Breast Pericanalicular Fibroadenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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