MCID: BRS031
MIFTS: 30

Breast Rhabdomyosarcoma

Categories: Cancer diseases

Aliases & Classifications for Breast Rhabdomyosarcoma

MalaCards integrated aliases for Breast Rhabdomyosarcoma:

Name: Breast Rhabdomyosarcoma 12 15 70
Rhabdomyosarcoma of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4060
NCIt 50 C5190
UMLS 70 C1332637

Summaries for Breast Rhabdomyosarcoma

Disease Ontology : 12 A breast sarcoma that arises from skeletal muscle cells.

MalaCards based summary : Breast Rhabdomyosarcoma, also known as rhabdomyosarcoma of the breast, is related to embryonal rhabdomyosarcoma and rhabdomyosarcoma 2. An important gene associated with Breast Rhabdomyosarcoma is MYOG (Myogenin), and among its related pathways/superpathways are Neural Crest Differentiation and Hematopoietic cell lineage. Affiliated tissues include breast, skeletal muscle and prostate, and related phenotypes are cellular and muscle

Related Diseases for Breast Rhabdomyosarcoma

Diseases related to Breast Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 embryonal rhabdomyosarcoma 29.8 PAX7 PAX3 MYOG MYOD1 MB IGF2
2 rhabdomyosarcoma 2 29.5 PAX7 PAX3 MYOG MYOD1 MB FOXO1
3 rhabdomyosarcoma 27.9 PAX7 PAX3 NES NCAM1 MYOG MYOD1
4 prostate embryonal rhabdomyosarcoma 10.4 MYOG MYOD1
5 undifferentiated embryonal sarcoma of the liver 10.4 MYOG MYOD1
6 embryonal sarcoma 10.4 MYOG MYOD1
7 gallbladder sarcoma 10.4 MYOG MYOD1
8 bladder sarcoma 10.4 MYOG MYOD1
9 prostate rhabdomyosarcoma 10.4 MYOG MYOD1
10 central nervous system rhabdomyosarcoma 10.4 PAX3 FOXO1
11 adult fibrosarcoma 10.4 MYOG MYOD1
12 medullomyoblastoma 10.4 MYOG MB
13 femoral neuropathy 10.3 MB CYGB
14 lung combined type small cell carcinoma 10.3 NCAM1 MYOG
15 cervical adenosarcoma 10.3 MYOG MYOD1
16 skeletal muscle neoplasm 10.3 MYOG MYOD1 MB
17 malignant triton tumor 10.3 MYOG MYOD1 MB
18 malignant mesenchymoma 10.3 MYOG MYOD1 MB
19 gas gangrene 10.3 MYOG MYOD1 MB
20 dacryocystocele 10.3 PAX3 NCAM1
21 chronic inflammation of lacrimal passage 10.3 PAX3 NCAM1
22 glomangiomatosis 10.3 NCAM1 MB
23 malignant fibrous histiocytoma 10.3 MYOG MYOD1 MB
24 synovium cancer 10.3 PAX3 MYOG FOXO1
25 clear cell basal cell carcinoma 10.3 PAX7 PAX3 MYOG
26 conventional leiomyosarcoma 10.3 PAX7 MYOG MYOD1
27 inflammatory leiomyosarcoma 10.3 PAX7 MYOG MYOD1
28 breast osteosarcoma 10.2 MYOG CD79A
29 bilateral retinoblastoma 10.2 MYOG MB
30 prostate stromal sarcoma 10.2 NCAM1 MYOG MYOD1
31 solitary osseous plasmacytoma 10.2 NCAM1 CD79A
32 monoclonal paraproteinemia 10.2 NCAM1 CD79A
33 x-linked recessive disease 10.2 PAX7 MYOG MYOD1
34 infected hydrocele 10.2 NCAM1 CD79A
35 botryoid rhabdomyosarcoma 10.2 PAX3 MYOG MYOD1 MB
36 spindle cell rhabdomyosarcoma 10.2 PAX3 MYOG MYOD1 MB
37 soft tissue sarcoma 10.2
38 x-linked monogenic disease 10.2 PAX7 MYOG MYOD1
39 gastrointestinal lymphoma 10.2 NCAM1 CD79A
40 facioscapulohumeral muscular dystrophy 1 10.1 PAX7 PAX3 MYOG MYOD1
41 muscle tissue disease 10.1 PAX7 MYOG MYOD1 MB
42 parameningeal embryonal rhabdomyosarcoma 10.1 PAX7 PAX3 MYOG FOXO1
43 rhabdoid cancer 10.1 MYOG MYOD1 IGF2
44 aleukemic leukemia cutis 10.1 CD33 ANPEP
45 central nervous system leukemia 10.1 CD33 ANPEP
46 angiomyoma 10.1 MB ENO2
47 breast leiomyosarcoma 10.1 MB ENO2
48 neuromuscular disease 10.1 NCAM1 MYOG MYOD1 MB
49 myoblastoma 10.0 MYOG ENO2
50 myelophthisic anemia 10.0 CD33 ANPEP

Graphical network of the top 20 diseases related to Breast Rhabdomyosarcoma:



Diseases related to Breast Rhabdomyosarcoma

Symptoms & Phenotypes for Breast Rhabdomyosarcoma

MGI Mouse Phenotypes related to Breast Rhabdomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.1 CD59 CD79A CYGB ENO2 ETS1 FOXO1
2 muscle MP:0005369 9.86 CYGB FOXO1 IGF2 MB MYOD1 MYOG
3 neoplasm MP:0002006 9.63 CD79A CYGB FOXO1 MYOD1 PAX3 PAX7
4 no phenotypic analysis MP:0003012 9.5 CD79A FOXO1 IGF2 MYOD1 MYOG PAX3
5 respiratory system MP:0005388 9.23 CYGB ENO2 IGF2 MB MYOD1 MYOG

Drugs & Therapeutics for Breast Rhabdomyosarcoma

Search Clinical Trials , NIH Clinical Center for Breast Rhabdomyosarcoma

Genetic Tests for Breast Rhabdomyosarcoma

Anatomical Context for Breast Rhabdomyosarcoma

MalaCards organs/tissues related to Breast Rhabdomyosarcoma:

40
Breast, Skeletal Muscle, Prostate, Myeloid, Kidney, Liver, Lung

Publications for Breast Rhabdomyosarcoma

Articles related to Breast Rhabdomyosarcoma:

(show all 29)
# Title Authors PMID Year
1
Primary Alveolar Rhabdomyosarcoma of the Breast in a 17-Year-Old Girl. 61
31770055 2020
2
Primary Rhabdomyosarcoma of the Breast: Study of Three Cases at One Institution with a Review of Primary Breast Sarcomas. 61
31370385 2019
3
Primary Alveolar Rhabdomyosarcoma of the Breast in an Adult: An Extremely Rare Case. 61
31032134 2019
4
WITHDRAWN:Primary Rhabdomyosarcoma of the Breast: A Report of Two Cases and Literature Review. 61
30286562 2018
5
Alveolar Rhabdomyosarcoma of the Breast in Adolescent Female. 61
30454495 2018
6
Primary Rhabdomyosarcoma of the Breast: Imaging Findings and Literature Review. 61
30319332 2018
7
Primary rhabdomyosarcoma of the breast in a 17-year-old girl: Case report. 61
29245322 2017
8
Rhabdomyosarcoma of the breast: Report of a rare malignancy. 61
28795902 2017
9
Rhabdomyosarcoma of the Breast in Adolescent and Young Adult (AYA) Women. 61
27879537 2017
10
Rhabdomyosarcoma of the breast: Report of two cases with the review of literature. 61
27046981 2016
11
Rhabdomyosarcoma of the breast - a rare malignancy. 61
23869249 2013
12
Rhabdomyosarcoma of the breast: a clinicopathologic study and review of the literature. 61
22882949 2012
13
Breast metastasis from multiple primary rhabdomyosarcoma in upper extremity. 61
24765424 2012
14
Primary spindle rhabdomyosarcoma of the breast in an adult female. 61
20678130 2011
15
Two rare breast tumors in a small community hospital. 61
21037526 2010
16
A case of primary rhabdomyosarcoma of the breast. 61
23132983 2007
17
Primary embryonal rhabdomyosarcoma of the breast. 61
17330703 2007
18
Primary rhabdomyosarcoma of the breast in a 13-year-old girl: report of a case. 61
17186344 2007
19
Rhabdomyosarcoma of the breast. 61
16153540 2005
20
Primary embryonal rhabdomyosarcoma of the breast in an adult female. 61
15871711 2005
21
[Rhabdomyosarcoma of the breast in girls]. 61
15449691 2004
22
Primary embryonal rhabdomyosarcoma of the breast in an adolescent female: a case report. 61
9802822 1998
23
Primary rhabdomyosarcoma of the female breast: report of a case and review of the literature. 61
9701340 1998
24
[Primary embryonal rhabdomyosarcoma of the breast. Description of a case]. 61
8072812 1994
25
Fatal breast rhabdomyosarcoma in a 15 year old primigravida. 61
2379516 1990
26
Alveolar rhabdomyosarcoma--a case report. 61
3223793 1988
27
Cytology of fine needle aspiration biopsy of primary breast rhabdomyosarcoma in an adolescent girl. 61
3859144 1985
28
Rhabdomyosarcoma of the breast. 61
6893144 1980
29
Rhabdomyosarcoma arising within a cystosarcoma phyllodes. Case report and review of the literature. 61
216277 1978

Variations for Breast Rhabdomyosarcoma

Expression for Breast Rhabdomyosarcoma

Search GEO for disease gene expression data for Breast Rhabdomyosarcoma.

Pathways for Breast Rhabdomyosarcoma

GO Terms for Breast Rhabdomyosarcoma

Biological processes related to Breast Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 PAX3 MYOG MYOD1 IGF2 FOXO1 ETS1
2 positive regulation of transcription, DNA-templated GO:0045893 9.91 PAX3 MYOG MYOD1 FOXO1 ETS1
3 regulation of transcription, DNA-templated GO:0006355 9.91 PAX7 PAX3 MYOG MYOD1 IGF2 FOXO1
4 positive regulation of myoblast differentiation GO:0045663 9.52 MYOG MYOD1
5 insulin receptor signaling pathway GO:0008286 9.5 IRS4 IGF2 FOXO1
6 multicellular organism development GO:0007275 9.5 PAX7 PAX3 NES MYOG MYOD1 IGF2
7 striated muscle cell differentiation GO:0051146 9.48 MYOD1 IGF2
8 myoblast differentiation GO:0045445 9.46 MYOG MYOD1
9 oxygen transport GO:0015671 9.43 MB CYGB
10 myotube differentiation GO:0014902 9.4 MYOG MYOD1
11 positive regulation of skeletal muscle fiber development GO:0048743 9.26 MYOG MYOD1
12 muscle cell fate commitment GO:0042693 9.16 MYOG MYOD1
13 muscle organ development GO:0007517 8.92 PAX7 PAX3 MYOG MYOD1

Molecular functions related to Breast Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.73 PAX7 PAX3 MYOG MYOD1 FOXO1 ETS1
2 sequence-specific DNA binding GO:0043565 9.35 PAX3 MYOG MYOD1 FOXO1 ETS1
3 oxygen carrier activity GO:0005344 9.16 MB CYGB
4 DNA-binding transcription factor activity GO:0003700 9.1 PAX7 PAX3 MYOG MYOD1 FOXO1 ETS1

Sources for Breast Rhabdomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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