MCID: BRS031
MIFTS: 28

Breast Rhabdomyosarcoma

Categories: Cancer diseases

Aliases & Classifications for Breast Rhabdomyosarcoma

MalaCards integrated aliases for Breast Rhabdomyosarcoma:

Name: Breast Rhabdomyosarcoma 12 15 73
Rhabdomyosarcoma of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4060
NCIt 50 C5190
UMLS 73 C1332637

Summaries for Breast Rhabdomyosarcoma

Disease Ontology : 12 A breast sarcoma that arises from skeletal muscle cells.

MalaCards based summary : Breast Rhabdomyosarcoma, also known as rhabdomyosarcoma of the breast, is related to embryonal rhabdomyosarcoma and rhabdomyosarcoma. An important gene associated with Breast Rhabdomyosarcoma is MB (Myoglobin), and among its related pathways/superpathways are TGF-beta Signaling Pathways and Regulation of nuclear SMAD2/3 signaling. Affiliated tissues include skeletal muscle and liver, and related phenotypes are growth/size/body region and mortality/aging

Related Diseases for Breast Rhabdomyosarcoma

Diseases related to Breast Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 embryonal rhabdomyosarcoma 29.4 FOXO1 MB MYOD1 MYOG
2 rhabdomyosarcoma 29.4 FOXO1 MB MYOD1 MYOG
3 rhabdomyosarcoma 2 28.7 FOXO1 KIDINS220 MB MYOD1 MYOG
4 orbit rhabdomyosarcoma 10.1 MB MYOG
5 mesenchymoma 10.0 MB MYOD1
6 leiomyosarcoma 10.0 MB MYOG
7 malignant triton tumor 10.0 MB MYOD1
8 botryoid rhabdomyosarcoma 10.0 MB MYOD1
9 spindle cell rhabdomyosarcoma 10.0 MB MYOD1
10 gallbladder sarcoma 10.0 MYOD1 MYOG
11 undifferentiated embryonal sarcoma of the liver 10.0 MYOD1 MYOG
12 embryonal sarcoma 10.0 MYOD1 MYOG
13 rhabdoid cancer 10.0 MB MYOD1
14 inflammatory leiomyosarcoma 10.0 MYOD1 MYOG
15 gas gangrene 10.0 MB MYOD1
16 conventional leiomyosarcoma 10.0 MYOD1 MYOG
17 spindle cell liposarcoma 9.9 MYOD1 MYOG
18 alveolar soft part sarcoma 9.9 MB MYOD1
19 nephrogenic adenofibroma 9.9 MYOD1 MYOG
20 muscle tissue disease 9.9 MB MYOD1
21 histiocytoma 9.9 MB MYOD1
22 central nervous system mesenchymal non-meningothelial tumor 9.9 FOXO1 MYOD1
23 adult fibrosarcoma 9.8 MB MYOD1 MYOG
24 medullomyoblastoma 9.8 MB MYOD1 MYOG
25 malignant mesenchymoma 9.8 MB MYOD1 MYOG
26 extraosseous ewing's sarcoma 9.8 KIDINS220 MYOD1 MYOG
27 myositis 9.8 MB MYOD1
28 pleomorphic rhabdomyosarcoma 9.7 FOXO1 MB MYOD1
29 ewing sarcoma 9.5 FOXO1 MYOD1 MYOG
30 muscle cancer 9.3 FOXO1 KIDINS220 MB MYOD1 MYOG
31 skeletal muscle cancer 9.3 FOXO1 KIDINS220 MB MYOD1 MYOG
32 muscular disease 9.3 FOXO1 KIDINS220 MB MYOD1 MYOG

Graphical network of the top 20 diseases related to Breast Rhabdomyosarcoma:



Diseases related to Breast Rhabdomyosarcoma

Symptoms & Phenotypes for Breast Rhabdomyosarcoma

MGI Mouse Phenotypes related to Breast Rhabdomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.65 FOXO1 KIDINS220 MB MYOD1 MYOG
2 mortality/aging MP:0010768 9.55 FOXO1 KIDINS220 MB MYOD1 MYOG
3 muscle MP:0005369 9.26 FOXO1 MB MYOD1 MYOG
4 no phenotypic analysis MP:0003012 8.92 FOXO1 KIDINS220 MYOD1 MYOG

Drugs & Therapeutics for Breast Rhabdomyosarcoma

Search Clinical Trials , NIH Clinical Center for Breast Rhabdomyosarcoma

Genetic Tests for Breast Rhabdomyosarcoma

Anatomical Context for Breast Rhabdomyosarcoma

MalaCards organs/tissues related to Breast Rhabdomyosarcoma:

41
Skeletal Muscle, Liver

Publications for Breast Rhabdomyosarcoma

Articles related to Breast Rhabdomyosarcoma:

(show all 13)
# Title Authors Year
1
Primary Rhabdomyosarcoma of the Breast: A Report of Two Cases and Literature Review. ( 30286562 )
2018
2
Primary Rhabdomyosarcoma of the Breast: Imaging Findings and Literature Review. ( 30319332 )
2018
3
Alveolar Rhabdomyosarcoma of the Breast in Adolescent Female. ( 30454495 )
2018
4
Rhabdomyosarcoma of the breast: Report of a rare malignancy. ( 28795902 )
2017
5
Primary rhabdomyosarcoma of the breast in a 17-year-old girl: Case report. ( 29245322 )
2017
6
Rhabdomyosarcoma of the Breast in Adolescent and Young Adult (AYA) Women. ( 27879537 )
2017
7
Primary spindle rhabdomyosarcoma of the breast in an adult female. ( 20678130 )
2011
8
Primary rhabdomyosarcoma of the breast in a 13-year-old girl: report of a case. ( 17186344 )
2007
9
A case of primary rhabdomyosarcoma of the breast. ( 23132983 )
2007
10
Rhabdomyosarcoma of the breast. ( 16153540 )
2005
11
Fatal breast rhabdomyosarcoma in a 15 year old primigravida. ( 2379516 )
1990
12
Cytology of fine needle aspiration biopsy of primary breast rhabdomyosarcoma in an adolescent girl. ( 3859144 )
1985
13
Rhabdomyosarcoma of the breast. ( 6893144 )
1980

Variations for Breast Rhabdomyosarcoma

Expression for Breast Rhabdomyosarcoma

Search GEO for disease gene expression data for Breast Rhabdomyosarcoma.

Pathways for Breast Rhabdomyosarcoma

Pathways related to Breast Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.24 FOXO1 MYOD1
2 11.04 FOXO1 MYOD1
3
Show member pathways
10.72 MYOD1 MYOG
4 10.21 FOXO1 MYOD1

GO Terms for Breast Rhabdomyosarcoma

Biological processes related to Breast Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.7 FOXO1 MYOD1 MYOG
2 cellular response to tumor necrosis factor GO:0071356 9.55 MYOD1 MYOG
3 muscle organ development GO:0007517 9.54 MYOD1 MYOG
4 cellular response to starvation GO:0009267 9.51 FOXO1 MYOD1
5 skeletal muscle tissue development GO:0007519 9.49 MYOD1 MYOG
6 skeletal muscle cell differentiation GO:0035914 9.48 MYOD1 MYOG
7 cellular response to estradiol stimulus GO:0071392 9.46 MYOD1 MYOG
8 positive regulation of muscle cell differentiation GO:0051149 9.43 MYOD1 MYOG
9 skeletal muscle fiber development GO:0048741 9.4 MYOD1 MYOG
10 positive regulation of myoblast differentiation GO:0045663 9.37 MYOD1 MYOG
11 myoblast differentiation GO:0045445 9.32 MYOD1 MYOG
12 positive regulation of myoblast fusion GO:1901741 9.26 MYOD1 MYOG
13 myotube differentiation GO:0014902 9.16 MYOD1 MYOG
14 positive regulation of skeletal muscle fiber development GO:0048743 8.96 MYOD1 MYOG
15 muscle cell fate commitment GO:0042693 8.62 MYOD1 MYOG

Molecular functions related to Breast Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.5 FOXO1 MYOD1 MYOG
2 sequence-specific DNA binding GO:0043565 9.43 FOXO1 MYOD1 MYOG
3 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.16 MYOD1 MYOG
4 chromatin DNA binding GO:0031490 8.96 MYOD1 MYOG
5 E-box binding GO:0070888 8.62 MYOD1 MYOG

Sources for Breast Rhabdomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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