MCID: BRS031
MIFTS: 29

Breast Rhabdomyosarcoma

Categories: Cancer diseases

Aliases & Classifications for Breast Rhabdomyosarcoma

MalaCards integrated aliases for Breast Rhabdomyosarcoma:

Name: Breast Rhabdomyosarcoma 12 15 74
Rhabdomyosarcoma of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4060
NCIt 51 C5190
UMLS 74 C1332637

Summaries for Breast Rhabdomyosarcoma

Disease Ontology : 12 A breast sarcoma that arises from skeletal muscle cells.

MalaCards based summary : Breast Rhabdomyosarcoma, also known as rhabdomyosarcoma of the breast, is related to embryonal rhabdomyosarcoma and rhabdomyosarcoma 2. An important gene associated with Breast Rhabdomyosarcoma is DES (Desmin), and among its related pathways/superpathways is TNFR1 Pathway. Affiliated tissues include breast, skeletal muscle and kidney, and related phenotypes are homeostasis/metabolism and mortality/aging

Related Diseases for Breast Rhabdomyosarcoma

Diseases related to Breast Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 embryonal rhabdomyosarcoma 29.3 DES MB MYOD1 MYOG
2 rhabdomyosarcoma 2 29.2 DES MB MYOD1 MYOG
3 rhabdomyosarcoma 28.5 DES MB MYOD1 MYOG PTPRC
4 giant cell myocarditis 10.1 DES MB
5 myofibroma 10.1 DES MB
6 bilateral retinoblastoma 10.1 DES MB
7 orbit rhabdomyosarcoma 10.1 MB MYOG
8 liposarcoma 10.1 DES MB
9 adenosarcoma 10.1 DES MB
10 pseudosarcomatous fibromatosis 10.0 DES MYOG
11 malignant fibrous histiocytoma of bone 10.0 DES MYOD1
12 horner's syndrome 10.0 DES MYOD1
13 undifferentiated embryonal sarcoma of the liver 10.0 MYOD1 MYOG
14 infantile myofibromatosis 10.0 DES MB
15 rhabdoid cancer 10.0 MB MYOD1
16 conventional leiomyosarcoma 10.0 MYOD1 MYOG
17 uterine sarcoma 10.0 DES MB
18 pleomorphic rhabdomyosarcoma 10.0 MB MYOD1
19 spindle cell liposarcoma 10.0 MYOD1 MYOG
20 gas gangrene 10.0 MB MYOD1
21 cavernous hemangioma 10.0 DES MB
22 primitive neuroectodermal tumor of the cervix uteri 9.9 DES PTPRC
23 nephrogenic adenofibroma 9.9 MYOD1 MYOG
24 reticulum cell sarcoma 9.9 DES PTPRC
25 kidney rhabdoid cancer 9.9 MB PTPRC
26 extraskeletal ewing sarcoma 9.9 DES PTPRC
27 extraosseous ewing's sarcoma 9.9 MYOD1 MYOG
28 plasmablastic lymphoma 9.9 DES PTPRC
29 leiomyosarcoma 9.8 DES MB MYOG
30 endometrial stromal sarcoma 9.8 DES MB
31 muscle tissue disease 9.8 MB MYOD1
32 thymus lipoma 9.8 MB PTPRC
33 immune system organ benign neoplasm 9.8 MB PTPRC
34 mesenchymoma 9.8 DES MB MYOD1
35 malignant triton tumor 9.8 DES MB MYOD1
36 botryoid rhabdomyosarcoma 9.8 DES MB MYOD1
37 gallbladder sarcoma 9.8 DES MYOD1 MYOG
38 spindle cell rhabdomyosarcoma 9.8 DES MB MYOD1
39 inflammatory leiomyosarcoma 9.8 DES MYOD1 MYOG
40 embryonal sarcoma 9.8 DES MYOD1 MYOG
41 alveolar soft part sarcoma 9.8 DES MB MYOD1
42 adult fibrosarcoma 9.7 MB MYOD1 MYOG
43 skeletal muscle cancer 9.7 MB MYOD1 MYOG
44 giant cell tumor 9.7 DES PTPRC
45 muscular disease 9.7 MB MYOD1 MYOG
46 myositis 9.6 MB MYOD1
47 malignant fibroxanthoma 9.6 DES MYOD1 PTPRC
48 rhabdoid tumor predisposition syndrome 1 9.6 DES MYOD1 PTPRC
49 histiocytoma 9.6 MB MYOD1 PTPRC
50 medullomyoblastoma 9.5 DES MB MYOD1 MYOG

Graphical network of the top 20 diseases related to Breast Rhabdomyosarcoma:



Diseases related to Breast Rhabdomyosarcoma

Symptoms & Phenotypes for Breast Rhabdomyosarcoma

MGI Mouse Phenotypes related to Breast Rhabdomyosarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.65 DES MB MYOD1 MYOG PTPRC
2 mortality/aging MP:0010768 9.55 DES MB MYOD1 MYOG PTPRC
3 muscle MP:0005369 9.26 DES MB MYOD1 MYOG
4 respiratory system MP:0005388 8.92 MB MYOD1 MYOG PTPRC

Drugs & Therapeutics for Breast Rhabdomyosarcoma

Search Clinical Trials , NIH Clinical Center for Breast Rhabdomyosarcoma

Genetic Tests for Breast Rhabdomyosarcoma

Anatomical Context for Breast Rhabdomyosarcoma

MalaCards organs/tissues related to Breast Rhabdomyosarcoma:

42
Breast, Skeletal Muscle, Kidney, Liver, Bone, Cervix, Thymus

Publications for Breast Rhabdomyosarcoma

Articles related to Breast Rhabdomyosarcoma:

(show all 20)
# Title Authors Year
1
Primary Alveolar Rhabdomyosarcoma of the Breast in an Adult: An Extremely Rare Case. ( 31032134 )
2019
2
WITHDRAWN:Primary Rhabdomyosarcoma of the Breast: A Report of Two Cases and Literature Review. ( 30286562 )
2018
3
Primary Rhabdomyosarcoma of the Breast: Imaging Findings and Literature Review. ( 30319332 )
2018
4
Alveolar Rhabdomyosarcoma of the Breast in Adolescent Female. ( 30454495 )
2018
5
Rhabdomyosarcoma of the breast: Report of a rare malignancy. ( 28795902 )
2017
6
Primary rhabdomyosarcoma of the breast in a 17-year-old girl: Case report. ( 29245322 )
2017
7
Rhabdomyosarcoma of the Breast in Adolescent and Young Adult (AYA) Women. ( 27879537 )
2017
8
Rhabdomyosarcoma of the breast: Report of two cases with the review of literature. ( 27046981 )
2016
9
Rhabdomyosarcoma of the breast - a rare malignancy. ( 23869249 )
2013
10
Rhabdomyosarcoma of the breast: a clinicopathologic study and review of the literature. ( 22882949 )
2012
11
Primary spindle rhabdomyosarcoma of the breast in an adult female. ( 20678130 )
2011
12
Primary embryonal rhabdomyosarcoma of the breast. ( 17330703 )
2007
13
A case of primary rhabdomyosarcoma of the breast. ( 23132983 )
2007
14
Primary rhabdomyosarcoma of the breast in a 13-year-old girl: report of a case. ( 17186344 )
2007
15
Primary embryonal rhabdomyosarcoma of the breast in an adult female. ( 15871711 )
2005
16
Rhabdomyosarcoma of the breast. ( 16153540 )
2005
17
Primary embryonal rhabdomyosarcoma of the breast in an adolescent female: a case report. ( 9802822 )
1998
18
Fatal breast rhabdomyosarcoma in a 15 year old primigravida. ( 2379516 )
1990
19
Cytology of fine needle aspiration biopsy of primary breast rhabdomyosarcoma in an adolescent girl. ( 3859144 )
1985
20
Rhabdomyosarcoma of the breast. ( 6893144 )
1980

Variations for Breast Rhabdomyosarcoma

Expression for Breast Rhabdomyosarcoma

Search GEO for disease gene expression data for Breast Rhabdomyosarcoma.

Pathways for Breast Rhabdomyosarcoma

GO Terms for Breast Rhabdomyosarcoma

Biological processes related to Breast Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cellular response to tumor necrosis factor GO:0071356 9.52 MYOD1 MYOG
2 muscle organ development GO:0007517 9.51 MYOD1 MYOG
3 skeletal muscle tissue development GO:0007519 9.49 MYOD1 MYOG
4 skeletal muscle cell differentiation GO:0035914 9.48 MYOD1 MYOG
5 cellular response to estradiol stimulus GO:0071392 9.46 MYOD1 MYOG
6 positive regulation of muscle cell differentiation GO:0051149 9.43 MYOD1 MYOG
7 skeletal muscle fiber development GO:0048741 9.4 MYOD1 MYOG
8 positive regulation of myoblast differentiation GO:0045663 9.37 MYOD1 MYOG
9 myoblast differentiation GO:0045445 9.32 MYOD1 MYOG
10 positive regulation of myoblast fusion GO:1901741 9.26 MYOD1 MYOG
11 myotube differentiation GO:0014902 9.16 MYOD1 MYOG
12 positive regulation of skeletal muscle fiber development GO:0048743 8.96 MYOD1 MYOG
13 muscle cell fate commitment GO:0042693 8.62 MYOD1 MYOG

Molecular functions related to Breast Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin DNA binding GO:0031490 8.96 MYOD1 MYOG
2 E-box binding GO:0070888 8.62 MYOD1 MYOG

Sources for Breast Rhabdomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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