MCID: BRS031
MIFTS: 22

Breast Rhabdomyosarcoma

Categories: Cancer diseases

Aliases & Classifications for Breast Rhabdomyosarcoma

MalaCards integrated aliases for Breast Rhabdomyosarcoma:

Name: Breast Rhabdomyosarcoma 12 15 73
Rhabdomyosarcoma of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4060
NCIt 50 C5190
UMLS 73 C1332637

Summaries for Breast Rhabdomyosarcoma

MalaCards based summary : Breast Rhabdomyosarcoma, also known as rhabdomyosarcoma of the breast, is related to rhabdomyosarcoma and giant cell myocarditis. An important gene associated with Breast Rhabdomyosarcoma is DES (Desmin), and among its related pathways/superpathways is Myogenesis. Affiliated tissues include breast, and related phenotypes are muscle and respiratory system

Related Diseases for Breast Rhabdomyosarcoma

Diseases related to Breast Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 rhabdomyosarcoma 26.7 DES ENO2 MB MYOD1 MYOG
2 giant cell myocarditis 10.3 DES MB
3 malignant triton tumor 10.3 DES MB
4 myofibroma 10.3 DES MB
5 bilateral retinoblastoma 10.3 DES MB
6 orbit rhabdomyosarcoma 10.2 MB MYOG
7 adenosarcoma 10.2 DES MB
8 pseudosarcomatous fibromatosis 10.2 DES MYOG
9 cervical polyp 10.2 DES MYOD1
10 infantile myofibromatosis 10.1 DES MB
11 horner's syndrome 10.1 DES MYOD1
12 malignant fibrous histiocytoma of bone 10.1 DES MYOD1
13 undifferentiated embryonal sarcoma of the liver 10.1 MYOD1 MYOG
14 uterine sarcoma 10.1 DES MB
15 conventional leiomyosarcoma 10.1 MYOD1 MYOG
16 rhabdoid cancer 10.1 DES MYOD1
17 pleomorphic rhabdomyosarcoma 10.1 MB MYOD1
18 spindle cell liposarcoma 10.0 MYOD1 MYOG
19 malignant fibroxanthoma 10.0 DES MYOD1
20 primitive neuroectodermal tumor of the cervix uteri 9.9 DES ENO2
21 malignant ectomesenchymoma 9.9 DES ENO2
22 ectomesenchymoma 9.9 DES ENO2
23 epulis 9.9 DES ENO2
24 nephrogenic adenofibroma 9.9 MYOD1 MYOG
25 ossifying fibromyxoid tumor 9.9 DES ENO2
26 epithelioid leiomyosarcoma 9.9 DES ENO2
27 liposarcoma 9.9 DES MB
28 desmoplastic small round cell tumor 9.9 DES ENO2
29 extraskeletal ewing sarcoma 9.9 DES ENO2
30 glomus tumor 9.9 DES ENO2
31 endometrial stromal sarcoma 9.9 DES MB
32 kidney rhabdoid cancer 9.8 ENO2 MB
33 granular cell tumor 9.8 DES ENO2
34 congenital epulis 9.8 DES ENO2
35 angiomyoma 9.8 ENO2 MB
36 muscle tissue disease 9.8 MB MYOD1
37 mixed cell type cancer 9.8 ENO2 MB
38 histiocytoma 9.8 MB MYOD1
39 pericardium cancer 9.7 ENO2 MB
40 cardiovascular organ benign neoplasm 9.7 ENO2 MB
41 benign perivascular tumor 9.7 ENO2 MB
42 spindle cell carcinoma 9.7 DES ENO2
43 pericardial mesothelioma 9.7 ENO2 MB
44 neurilemmoma 9.7 DES ENO2
45 acute mountain sickness 9.6 ENO2 MB
46 botryoid rhabdomyosarcoma 9.6 DES MB MYOD1
47 gallbladder sarcoma 9.6 DES MYOD1 MYOG
48 mesenchymoma 9.6 DES MB MYOD1
49 spindle cell rhabdomyosarcoma 9.6 DES MB MYOD1
50 inflammatory leiomyosarcoma 9.6 DES MYOD1 MYOG

Graphical network of the top 20 diseases related to Breast Rhabdomyosarcoma:



Diseases related to Breast Rhabdomyosarcoma

Symptoms & Phenotypes for Breast Rhabdomyosarcoma

MGI Mouse Phenotypes related to Breast Rhabdomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.26 DES MB MYOD1 MYOG
2 respiratory system MP:0005388 8.92 ENO2 MB MYOD1 MYOG

Drugs & Therapeutics for Breast Rhabdomyosarcoma

Search Clinical Trials , NIH Clinical Center for Breast Rhabdomyosarcoma

Genetic Tests for Breast Rhabdomyosarcoma

Anatomical Context for Breast Rhabdomyosarcoma

MalaCards organs/tissues related to Breast Rhabdomyosarcoma:

41
Breast

Publications for Breast Rhabdomyosarcoma

Articles related to Breast Rhabdomyosarcoma:

# Title Authors Year
1
Fatal breast rhabdomyosarcoma in a 15 year old primigravida. ( 2379516 )
1990
2
Cytology of fine needle aspiration biopsy of primary breast rhabdomyosarcoma in an adolescent girl. ( 3859144 )
1985

Variations for Breast Rhabdomyosarcoma

Expression for Breast Rhabdomyosarcoma

Search GEO for disease gene expression data for Breast Rhabdomyosarcoma.

Pathways for Breast Rhabdomyosarcoma

Pathways related to Breast Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.39 MYOD1 MYOG

GO Terms for Breast Rhabdomyosarcoma

Biological processes related to Breast Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cellular response to tumor necrosis factor GO:0071356 9.52 MYOD1 MYOG
2 muscle organ development GO:0007517 9.51 MYOD1 MYOG
3 skeletal muscle tissue development GO:0007519 9.49 MYOD1 MYOG
4 skeletal muscle cell differentiation GO:0035914 9.48 MYOD1 MYOG
5 cellular response to estradiol stimulus GO:0071392 9.46 MYOD1 MYOG
6 skeletal muscle fiber development GO:0048741 9.43 MYOD1 MYOG
7 positive regulation of muscle cell differentiation GO:0051149 9.4 MYOD1 MYOG
8 positive regulation of myoblast differentiation GO:0045663 9.37 MYOD1 MYOG
9 myoblast differentiation GO:0045445 9.32 MYOD1 MYOG
10 positive regulation of myoblast fusion GO:1901741 9.26 MYOD1 MYOG
11 myotube differentiation GO:0014902 9.16 MYOD1 MYOG
12 positive regulation of skeletal muscle fiber development GO:0048743 8.96 MYOD1 MYOG
13 muscle cell fate commitment GO:0042693 8.62 MYOD1 MYOG

Molecular functions related to Breast Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.26 MYOD1 MYOG
2 core promoter binding GO:0001047 9.16 MYOD1 MYOG
3 chromatin DNA binding GO:0031490 8.96 MYOD1 MYOG
4 E-box binding GO:0070888 8.62 MYOD1 MYOG

Sources for Breast Rhabdomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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