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MCID: BRS061
MIFTS: 27

Breast Sarcoma

Categories: Cancer diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Breast Sarcoma

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MalaCards integrated aliases for Breast Sarcoma:

Name: Breast Sarcoma 12 15
Sarcoma of Breast 12 73

Classifications:

MalaCards categories:
Global: Cancer diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3017
NCIt 50 C4670
UMLS 73 C0349667
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Summaries for Breast Sarcoma

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Disease Ontology : 12 A breast cancer that has material basis in abnormally proliferating cells derives from mesenchymal cells.

MalaCards based summary : Breast Sarcoma, also known as sarcoma of breast, is related to breast angiosarcoma and breast rhabdomyosarcoma. An important gene associated with Breast Sarcoma is ITGA4 (Integrin Subunit Alpha 4). The drugs Epirubicin and Docetaxel have been mentioned in the context of this disorder. Affiliated tissues include breast, brain and myeloid.

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Related Diseases for Breast Sarcoma

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Diseases related to Breast Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 breast angiosarcoma 30.7 ANGPTL8 HBA1 SCN8A
2 breast rhabdomyosarcoma 11.0
3 breast leiomyosarcoma 11.0
4 breast liposarcoma 11.0
5 breast fibrosarcoma 11.0
6 breast osteosarcoma 11.0
7 sarcoma 10.5
8 myeloid sarcoma 9.9
9 osteogenic sarcoma 9.7
10 leukemia 9.7
11 breast fibroadenoma 9.7
12 squamous cell carcinoma 9.7
13 malignant fibroxanthoma 9.7
14 cervix carcinoma 9.7
15 histiocytoma 9.7
16 fibrous histiocytoma 9.7
17 myeloid leukemia 9.7
18 intussusception 9.7
19 li-fraumeni syndrome 9.7
20 li-fraumeni syndrome 2 9.7
21 spindle cell sarcoma 9.7

Graphical network of the top 20 diseases related to Breast Sarcoma:



Diseases related to Breast Sarcoma
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Symptoms & Phenotypes for Breast Sarcoma

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Drugs & Therapeutics for Breast Sarcoma

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Drugs for Breast Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epirubicin Approved Phase 2, Phase 3 56420-45-2 41867
2
Docetaxel Approved, Investigational Phase 2, Phase 3 114977-28-5 148124
3
Adenosine Approved, Investigational Phase 2, Phase 3 58-61-7 60961
4
Trastuzumab Approved, Investigational Phase 2, Phase 3 180288-69-1 9903
5
Pertuzumab Approved Phase 2, Phase 3 145040-37-5, 380610-27-5 2540
6
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 6055-19-2, 50-18-0 2907
7 Antimitotic Agents Phase 2, Phase 3
8 Ado-trastuzumab emtansine Phase 2, Phase 3
9
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
10
Goserelin Approved Phase 2 65807-02-5 47725 5311128
11
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
12
Exemestane Approved, Investigational Phase 2 107868-30-4 60198
13
Tamoxifen Approved Phase 2 10540-29-1 2733526
14
Phenobarbital Approved, Investigational Phase 2 50-06-6 4763
15
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
16
Palbociclib Approved, Investigational Phase 2 571190-30-2 11431660 5330286 5005498
17 Bone Density Conservation Agents Phase 2
18 Estrogen Antagonists Phase 2
19 Neurotransmitter Agents Phase 2
20 Central Nervous System Depressants Phase 2
21 Antineoplastic Agents, Hormonal Phase 2
22 Selective Estrogen Receptor Modulators Phase 2
23 Excitatory Amino Acids Phase 2
24 Antineoplastic Agents, Phytogenic Phase 2
25 Cytochrome P-450 CYP3A Inducers Phase 2
26 Steroid Synthesis Inhibitors Phase 2
27 Cyclin-Dependent Kinase Inhibitor Proteins Phase 2
28 Protein Kinase Inhibitors Phase 2
29 Hormones Phase 2
30 Excitatory Amino Acid Antagonists Phase 2
31 Hormone Antagonists Phase 2
32 Albumin-Bound Paclitaxel Phase 2
33 Estrogen Receptor Modulators Phase 2
34 GABA Agents Phase 2
35 Anticonvulsants Phase 2
36 Estrogens Phase 2
37 Hypnotics and Sedatives Phase 2
38 Aromatase Inhibitors Phase 2
39 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
40 GABA Modulators Phase 2
41 Estrogen Receptor Antagonists Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Neoadjuvant Response-guided Treatment of HER2 Positive Breast Cancer Recruiting NCT02568839 Phase 2, Phase 3 docetaxel + trastuzumab sc + pertuzumab;trastuzumab emtansin
2 Neoadjuvant Response-guided Treatment of Luminal B-type Tumors and Luminal A-type Tumors With Node Metastases Recruiting NCT02603679 Phase 2 Paclitaxel;Tamoxifen + Palbociclib;Aromatase Inhibitor + Palbociclib;Goserelin + Aromatase Inhibitor + Palbociclib
3 Neoadjuvant Response-guided Treatment of Slowly Proliferating Hormone Receptor Positive Tumors Recruiting NCT02592083 Phase 2 Tamoxifen or Aromatase Inhibitor or Aromatase Inhibitor + goserelin;Palbociclib

Search NIH Clinical Center for Breast Sarcoma

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Genetic Tests for Breast Sarcoma

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Anatomical Context for Breast Sarcoma

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MalaCards organs/tissues related to Breast Sarcoma:

41
Breast, Brain, Myeloid, Lymph Node, Cervix
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Publications for Breast Sarcoma

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Articles related to Breast Sarcoma:

(show top 50) (show all 63)
# Title Authors Year
1
The Role of Adjuvant Radiotherapy for a Case of Primary Breast Sarcoma: A Plan Comparison between Three Modern Techniques and a Review of the Literature. ( 29849658 )
2018
2
Impact of Insurance Coverage on Outcomes in Primary Breast Sarcoma. ( 29736143 )
2018
3
Advanced Stage Breast Sarcoma Treatment in a Third World Country Public Hospital. ( 30174970 )
2018
4
Imaging findings of primary breast sarcoma: Results of a first multicenter study. ( 28189193 )
2017
5
Pleomorphic Sarcoma of Breast: A Report of Two Cases and Review of Literature. ( 28532141 )
2017
6
Early Local Recurrence Presents Adverse Effect on Outcomes of Primary Breast Sarcoma: A Retrospective Study From Single Institute in China. ( 26735546 )
2016
7
Management of Breast Sarcoma. ( 27542642 )
2016
8
Primary breast sarcoma: A retrospective study over 35 years from a single institution. ( 26586158 )
2016
9
A Scary Onset of a Rare and Aggressive Type of Primary Breast Sarcoma: A Case Report. ( 28101028 )
2016
10
Bilateral Myeloid Sarcoma of Breast in a Young Male Occurring after 11 Years of Chronic Myeloid Leukemia Diagnosis: A Unique Pattern of Relapse. ( 27488267 )
2016
11
Primary female breast sarcoma: clinicopathological features, treatment and prognosis. ( 27510467 )
2016
12
Breast sarcoma. A case report and review of literature. ( 27281361 )
2016
13
Primary Stromal Sarcoma of Breast: A Rare Entity. ( 28974969 )
2016
14
Spontaneous Perforation as a First Presentation of Ileal Gastrointestinal Stromal Tumour (GIST) with Synchronous Breast Sarcoma. ( 24995213 )
2014
15
Breast sarcoma: a rare malignancy. ( 24965425 )
2014
16
Breast sarcoma after breast-conserving therapy for breast cancer in a patient with Li-Fraumeni syndrome presenting as focal nonmasslike enhancement on MRI. ( 24261401 )
2013
17
Breast sarcoma. ( 23552541 )
2013
18
Cytologic diagnosis of undifferentiated high grade pleomorphic sarcoma of breast presenting with brain metastasis. ( 23914101 )
2013
19
Recurrent phyllodes sarcoma of breast with complete chest wall invasion; a multidisciplinary approach for radical resection. ( 23425565 )
2013
20
Breast sarcoma in a pregnant patient A case report. ( 23070281 )
2012
21
Imaging features of primary breast sarcoma. ( 22451578 )
2012
22
The CD49d+/high subpopulation from isolated human breast sarcoma spheres possesses tumor-initiating ability. ( 22159714 )
2012
23
Primary stromal sarcoma of breast with malignant fibrous histiocytoma-like features causing diagnostic dilemma on fine-needle aspiration cytology in a patient with squamous cell carcinoma of cervix: a case report. ( 20607805 )
2011
24
Primary breast sarcoma: prevalence, clinical signs, and radiological features. ( 21565891 )
2011
25
Treatment for breast sarcoma: a large, single-centre series. ( 21628089 )
2011
26
Diagnosis and management of primary breast sarcoma. ( 20480227 )
2010
27
Breast sarcoma--a review of diagnosis and management. ( 19114317 )
2009
28
Primary breast sarcoma. ( 18514698 )
2008
29
Treatment and outcomes of patients with primary breast sarcoma. ( 18723152 )
2008
30
Primary osteogenic sarcoma of breast detected on Tc-99m MIBI scintigraphy and Tc-99m MDP skeletal scintigraphy. ( 18250991 )
2008
31
Periductal stromal sarcoma of breast with lipoblast-like cells: a case report with review of literature. ( 18603698 )
2008
32
Granulocytic sarcoma of breast: an aleukemic presentation. ( 17337816 )
2007
33
Outcome and prognostic factors in breast sarcoma: a multicenter study from the rare cancer network. ( 18023492 )
2007
34
Good outcome after neoadjuvant chemotherapy and extended surgical resection for a large radiation-induced high-grade breast sarcoma. ( 16824232 )
2006
35
Report on a case of breast sarcoma metastatic to the axillary lymph nodes. ( 16724703 )
2006
36
A rare case of breast sarcoma brain metastases. ( 15925991 )
2005
37
Primary breast sarcoma: case report. ( 15490711 )
2004
38
Primary breast sarcoma: clinicopathologic series from the Mayo Clinic and review of the literature. ( 15187996 )
2004
39
Delivery of an anticancer drug and a chemosensitizer to murine breast sarcoma by intratumoral injection of sulfopropyl dextran microspheres. ( 12956895 )
2003
40
Breast sarcoma showing myofibroblastic differentiation. ( 12844261 )
2003
41
Surgical management of primary breast sarcoma. ( 12206600 )
2002
42
P53 expression is a factor for prognostic assessment in breast sarcoma. ( 12002339 )
2002
43
An unusual case of metastatic post-irradiation breast sarcoma. ( 14965694 )
2002
44
Radiation-induced breast sarcoma. ( 12383902 )
2002
45
An analysis of 78 breast sarcoma patients without distant metastases at presentation. ( 10661345 )
2000
46
Stromal sarcoma of breast: a case report. ( 11016187 )
2000
47
F-18 FDG whole-body positron emission tomography scan in primary breast sarcoma. ( 9735983 )
1998
48
Breast sarcoma. ( 8610270 )
1996
49
Human breast sarcoma and human breast implantation: a time trend analysis based on SEER data (1973-1990). ( 7722610 )
1995
50
High-dose interferon-beta in treatment of spindle-cell sarcoma of breast. ( 2145946 )
1990
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Variations for Breast Sarcoma

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Expression for Breast Sarcoma

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Search GEO for disease gene expression data for Breast Sarcoma.
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Pathways for Breast Sarcoma

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GO Terms for Breast Sarcoma

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Cellular components related to Breast Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth cone GO:0030426 8.62 ITGA4 STIM1
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Sources for Breast Sarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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