MCID: BRS061
MIFTS: 32

Breast Sarcoma

Categories: Cancer diseases

Aliases & Classifications for Breast Sarcoma

MalaCards integrated aliases for Breast Sarcoma:

Name: Breast Sarcoma 12 15
Sarcoma of Breast 12 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3017
NCIt 50 C4670
SNOMED-CT 67 278050001
UMLS 70 C0349667

Summaries for Breast Sarcoma

Disease Ontology : 12 A breast cancer that has material basis in abnormally proliferating cells derives from mesenchymal cells.

MalaCards based summary : Breast Sarcoma, also known as sarcoma of breast, is related to breast osteosarcoma and angiosarcoma. An important gene associated with Breast Sarcoma is ITGA4 (Integrin Subunit Alpha 4), and among its related pathways/superpathways are Cell adhesion molecules and MAPK Pathway. Affiliated tissues include breast, liver and skin, and related phenotypes are cardiovascular system and immune system

Related Diseases for Breast Sarcoma

Diseases related to Breast Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 351)
# Related Disease Score Top Affiliating Genes
1 breast osteosarcoma 30.4 PGR MYOG MME KRT5 ERBB2
2 angiosarcoma 30.2 TP53 TIE1 PECAM1 CD34
3 benign breast phyllodes tumor 30.2 PGR MME CD34
4 embryonal sarcoma 30.0 TP53 MYOG
5 malignant mesenchymoma 30.0 MYOG CD34
6 liposarcoma 30.0 TP53 MYOG CD34
7 hemangiopericytoma, malignant 29.7 PECAM1 MYOG CD34
8 myxofibrosarcoma 29.6 TP53 MYOG CD34
9 breast fibroadenoma 29.6 TP53 PGR MME ERBB2
10 malignant peripheral nerve sheath tumor 29.6 TP53 MYOG CD34
11 carcinosarcoma 29.6 TP53 PGR MME ERBB2
12 leiomyosarcoma 29.6 TP53 PGR PECAM1 MYOG
13 gastrointestinal stromal tumor 29.4 TP53 TIE1 ERBB2 CD34
14 breast angiosarcoma 29.1 TIE1 SNRK PECAM1 NETO1 CD34
15 breast ductal carcinoma 29.1 TP53 PGR KRT5 ERBB2
16 breast disease 29.0 TP53 PGR KRT5 ERBB2
17 breast rhabdomyosarcoma 11.0
18 breast leiomyosarcoma 11.0
19 breast liposarcoma 11.0
20 breast fibrosarcoma 11.0
21 sarcoma 10.6
22 spindle cell sarcoma 10.6
23 glomangioma 10.4 PECAM1 CD34
24 skin epithelioid hemangioma 10.4 PECAM1 CD34
25 aortic malignant tumor 10.4 PECAM1 CD34
26 prostate angiosarcoma 10.4 PECAM1 CD34
27 central nervous system angiosarcoma 10.4 PECAM1 CD34
28 intravascular angioleiomyoma 10.4 PECAM1 CD34
29 central nervous system hemangioma 10.4 PECAM1 CD34
30 heart fibrosarcoma 10.4 PECAM1 CD34
31 ovarian angiosarcoma 10.4 PECAM1 CD34
32 conventional angiosarcoma 10.3 PECAM1 CD34
33 gallbladder leiomyosarcoma 10.3 PECAM1 CD34
34 thyroid sarcoma 10.3 PECAM1 CD34
35 angiomyoma 10.3 PECAM1 CD34
36 eccrine mixed tumor of skin 10.3 PECAM1 ERBB2
37 retroperitoneal hemangiopericytoma 10.3 PECAM1 CD34
38 glomangiosarcoma 10.3 PECAM1 CD34
39 hemangioma of spleen 10.3 PECAM1 CD34
40 intramuscular hemangioma 10.3 PECAM1 CD34
41 colonic lymphangioma 10.3 PECAM1 CD34
42 pulmonary vein leiomyosarcoma 10.3 PGR CD34
43 benign perivascular tumor 10.3 PECAM1 CD34
44 erythema elevatum diutinum 10.3 PECAM1 CD34
45 kaposiform hemangioendothelioma 10.3 PECAM1 CD34
46 lung meningioma 10.3 PGR CD34
47 capillary lymphangioma 10.3 PECAM1 CD34
48 bacillary angiomatosis 10.3 PECAM1 CD34
49 subungual glomus tumor 10.3 PECAM1 CD34
50 glassy cell carcinoma of the cervix 10.3 PGR ERBB2

Graphical network of the top 20 diseases related to Breast Sarcoma:



Diseases related to Breast Sarcoma

Symptoms & Phenotypes for Breast Sarcoma

MGI Mouse Phenotypes related to Breast Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 ERBB2 ITGA4 MME PECAM1 PGR SNRK
2 immune system MP:0005387 9.81 CD34 ITGA4 KRT5 MME PECAM1 PGR
3 integument MP:0010771 9.61 CD34 ERBB2 KRT5 MME MYOG PGR
4 muscle MP:0005369 9.17 ERBB2 MYOG PECAM1 PGR SNRK TIE1

Drugs & Therapeutics for Breast Sarcoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Breast Sarcomas: A Retrospective Analysis of Clinical Features and Outcomes Not yet recruiting NCT04749446

Search NIH Clinical Center for Breast Sarcoma

Genetic Tests for Breast Sarcoma

Anatomical Context for Breast Sarcoma

MalaCards organs/tissues related to Breast Sarcoma:

40
Breast, Liver, Skin, Cervix, Heart, Lung, Myeloid

Publications for Breast Sarcoma

Articles related to Breast Sarcoma:

(show top 50) (show all 161)
# Title Authors PMID Year
1
A rare case report of breast sarcoma. 61
33680274 2021
2
Angiosarcoma associated with radiation therapy after treatment of breast cancer. Retrospective study on ten years. 61
33487559 2021
3
Chemotherapy and targeted treatments of breast sarcoma by histologic subtype. 61
33554686 2021
4
Primary stromal sarcoma of breast: A case report and literature review. 61
33720870 2021
5
A need for clarity on surgical management of breast sarcoma: Scottish sarcoma network guidelines and regional audit. 61
33308991 2020
6
Sarcoma of the breast: breast cancer history as etiologic and prognostic factor-A population-based case-control study. 61
32696318 2020
7
Residual Breast Sarcoma Left to Heal by Secondary Intention Following Wide Local Excision: An Unorthodox Approach to a Rare Malignancy. 61
33062546 2020
8
Cowden syndrome is a risk factor for multiple neoplasm: a case report. 61
32807196 2020
9
Radiation-induced undifferentiated pleomorphic sarcoma of the breast. 61
32047082 2020
10
Not Otherwise Specified-Type Sarcoma of Breast with CD10 Expression: Case Report. 61
31620687 2019
11
Neoadjuvant chemotherapy for primary sarcoma of the breast: a case report. 61
31488201 2019
12
Primary Rhabdomyosarcoma of the Breast: Study of Three Cases at One Institution with a Review of Primary Breast Sarcomas. 61
31370385 2019
13
Cluster of Differentiation 10 Positive Stromal Sarcoma of Breast: A Diagnostic Challenge. 61
31523571 2019
14
Reconstruction options and outcomes for breast sarcoma patients. 61
31025484 2019
15
Breast Sarcomas: Experience of a Reference Center in Colombia. 61
31516788 2019
16
Primary Stromal Breast Sarcoma with Concomitant Contralateral Carcinoma: A Rare Case from Syria. 61
31583145 2019
17
Malignant Spindle Cell Tumor Breast-a Diagnostic Dilemma. 61
30288003 2018
18
Sarcomas of the Breast. 61
30005780 2018
19
The presence of glutamate residues on the PAS sequence of the stimuli-sensitive nano-ferritin improves in vivo biodistribution and mitoxantrone encapsulation homogeneity. 61
29474961 2018
20
Contribution of de novo and mosaic TP53 mutations to Li-Fraumeni syndrome. 61
29070607 2018
21
Impact of Insurance Coverage on Outcomes in Primary Breast Sarcoma. 61
29736143 2018
22
Advanced Stage Breast Sarcoma Treatment in a Third World Country Public Hospital. 61
30174970 2018
23
The Role of Adjuvant Radiotherapy for a Case of Primary Breast Sarcoma: A Plan Comparison between Three Modern Techniques and a Review of the Literature. 61
29849658 2018
24
Primary Leiomyosarcoma of Breast Presenting with Metastasis: An Atypical Presentation with Dismal Prognosis. 61
29333025 2017
25
Unusual primary breast cancer - malignant peripheral nerve sheath tumor: a case report and review of the literature. 61
28622765 2017
26
Pleomorphic Sarcoma of Breast: A Report of Two Cases and Review of Literature. 61
28532141 2017
27
Imaging findings of primary breast sarcoma: Results of a first multicenter study. 61
28189193 2017
28
[Primary breast sarcomas: About 30 cases treated at Salah-Azaiez institute in Tunisia]. 61
28223032 2017
29
Breast cancer in patients with Li-Fraumeni syndrome - a case-series study and review of literature. 61
28356770 2017
30
Bilateral Myeloid Sarcoma of Breast in a Young Male Occurring after 11 Years of Chronic Myeloid Leukemia Diagnosis: A Unique Pattern of Relapse. 61
27488267 2016
31
Management of Breast Sarcoma. 61
27542642 2016
32
A Scary Onset of a Rare and Aggressive Type of Primary Breast Sarcoma: A Case Report. 61
28101028 2016
33
Primary female breast sarcoma: clinicopathological features, treatment and prognosis. 61
27510467 2016
34
Defining Action Levels for In Vivo Dosimetry in Intraoperative Electron Radiotherapy. 61
26025385 2016
35
Sarcoma of the breast: an update on a rare entity. 61
26729013 2016
36
Primary breast sarcoma: A retrospective study over 35 years from a single institution. 61
26586158 2016
37
Early Local Recurrence Presents Adverse Effect on Outcomes of Primary Breast Sarcoma: A Retrospective Study From Single Institute in China. 61
26735546 2016
38
Primary Stromal Sarcoma of Breast: A Rare Entity. 61
28974969 2016
39
Breast sarcoma. A case report and review of literature. 61
27281361 2016
40
Phyllodes tumours of the breast: a consensus review. 61
26768026 2016
41
Primary leiomyosarcoma of the breast with prominent osteoclastic giant cells: A case expressing receptor activator of NF-κB ligand (RANKL). 61
26150133 2015
42
Giant cell variant of malignant fibrous histiocytoma of male breast: A rare case report. 61
26458656 2015
43
Angiosarcoma in previously irradiated breast in patient with Li-Fraumeni syndrome. A case report. 61
25271877 2015
44
Comparison of the clinical and prognostic features of primary breast sarcomas and malignant phyllodes tumor. 61
25387733 2015
45
Ventricular tachycardia associated with radiation-induced cardiac sarcoma. 61
25593527 2014
46
Optimal management of sarcomas of the breast: an update. 61
24611696 2014
47
Spontaneous Perforation as a First Presentation of Ileal Gastrointestinal Stromal Tumour (GIST) with Synchronous Breast Sarcoma. 61
24995213 2014
48
Breast sarcoma: a rare malignancy. 61
24965425 2014
49
Primary fibrosarcoma of male breast: a rare entity. 61
24959458 2014
50
Huge primary soft tissue sarcoma of the breast on bone scan. 61
24152643 2014

Variations for Breast Sarcoma

Expression for Breast Sarcoma

Search GEO for disease gene expression data for Breast Sarcoma.

Pathways for Breast Sarcoma

Pathways related to Breast Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.61 PECAM1 ITGA4 CD34
2
Show member pathways
11.43 TP53 ITGA4 ERBB2
3 11.13 MME ITGA4 CD34
4
Show member pathways
11.11 TP53 TIE1 ITGA4 ERBB2

GO Terms for Breast Sarcoma

Biological processes related to Breast Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 replicative senescence GO:0090399 9.26 TP53 MME
2 paracrine signaling GO:0038001 9.16 PGR CD34
3 diapedesis GO:0050904 8.96 PECAM1 ITGA4
4 glomerular endothelium development GO:0072011 8.62 PECAM1 CD34

Sources for Breast Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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