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MCID: BRS061
MIFTS: 35

Breast Sarcoma

Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Breast Sarcoma

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MalaCards integrated aliases for Breast Sarcoma:

Name: Breast Sarcoma 12 15
Sarcoma of Breast 12 74

Classifications:

MalaCards categories:
Global: Cancer diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3017
NCIt 51 C4670
UMLS 74 C0349667
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Summaries for Breast Sarcoma

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Disease Ontology : 12 A breast cancer that has material basis in abnormally proliferating cells derives from mesenchymal cells.

MalaCards based summary : Breast Sarcoma, also known as sarcoma of breast, is related to breast rhabdomyosarcoma and breast leiomyosarcoma. An important gene associated with Breast Sarcoma is ITGA4 (Integrin Subunit Alpha 4), and among its related pathways/superpathways are Actin Nucleation by ARP-WASP Complex and ECM-receptor interaction. The drugs Adenosine and Epirubicin have been mentioned in the context of this disorder. Affiliated tissues include breast, myeloid and cervix.

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Related Diseases for Breast Sarcoma

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Diseases related to Breast Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 breast rhabdomyosarcoma 11.1
2 breast leiomyosarcoma 11.1
3 breast liposarcoma 11.1
4 breast fibrosarcoma 11.1
5 breast osteosarcoma 11.1
6 breast angiosarcoma 11.0
7 sarcoma 10.5
8 spindle cell sarcoma 10.1
9 myeloid sarcoma 9.9
10 hydrocele 9.9 ITGA4 PECAM1
11 pulmonary vein stenosis 9.9 ACTC1 PECAM1
12 juvenile nasopharyngeal angiofibroma 9.8 ACTC1 PECAM1
13 osteogenic sarcoma 9.7
14 leukemia 9.7
15 breast fibroadenoma 9.7
16 squamous cell carcinoma 9.7
17 malignant fibroxanthoma 9.7
18 cervix carcinoma 9.7
19 histiocytoma 9.7
20 fibrous histiocytoma 9.7
21 myeloid leukemia 9.7
22 undifferentiated pleomorphic sarcoma 9.7
23 breast cancer 9.7
24 intussusception 9.7
25 li-fraumeni syndrome 9.7
26 gastrointestinal stromal tumor 9.7
27 li-fraumeni syndrome 2 9.7
28 benign breast phyllodes tumor 9.7
29 rhabdomyosarcoma 9.7
30 hemangioma 9.7 ACTC1 PECAM1

Graphical network of the top 20 diseases related to Breast Sarcoma:



Diseases related to Breast Sarcoma
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Symptoms & Phenotypes for Breast Sarcoma

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Drugs & Therapeutics for Breast Sarcoma

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Drugs for Breast Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adenosine Approved, Investigational Phase 2, Phase 3 58-61-7 60961
2
Epirubicin Approved Phase 2, Phase 3 56420-45-2 41867
3
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
4
Docetaxel Approved, Investigational Phase 2, Phase 3 114977-28-5 148124
5
Pertuzumab Approved Phase 2, Phase 3 380610-27-5, 145040-37-5 2540
6
Trastuzumab Approved, Investigational Phase 2, Phase 3 180288-69-1 9903
7 Antimitotic Agents Phase 2, Phase 3
8 Ado-trastuzumab emtansine Phase 2, Phase 3
9 Antineoplastic Agents, Immunological Phase 2, Phase 3
10
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
11
Phenobarbital Approved, Investigational Phase 2 50-06-6 4763
12
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
13
Exemestane Approved, Investigational Phase 2 107868-30-4 60198
14
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
15
Goserelin Approved Phase 2 65807-02-5 5311128 47725
16
Palbociclib Approved, Investigational Phase 2 571190-30-2 5005498 11431660 5330286
17
Tamoxifen Approved Phase 2 10540-29-1 2733526
18 Antineoplastic Agents, Hormonal Phase 2
19 Bone Density Conservation Agents Phase 2
20 Estrogen Receptor Antagonists Phase 2
21 GABA Modulators Phase 2
22 Excitatory Amino Acids Phase 2
23 Albumin-Bound Paclitaxel Phase 2
24 Neurotransmitter Agents Phase 2
25 Hormones Phase 2
26 Steroid Synthesis Inhibitors Phase 2
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
28 Central Nervous System Depressants Phase 2
29 Excitatory Amino Acid Antagonists Phase 2
30 Hormone Antagonists Phase 2
31 Hypnotics and Sedatives Phase 2
32 Estrogens Phase 2
33 Antineoplastic Agents, Phytogenic Phase 2
34 Protein Kinase Inhibitors Phase 2
35 Aromatase Inhibitors Phase 2
36 Cytochrome P-450 CYP3A Inducers Phase 2
37 Estrogen Antagonists Phase 2
38 Anticonvulsants Phase 2
39 Estrogen Receptor Modulators Phase 2
40 Selective Estrogen Receptor Modulators Phase 2
41 Cyclin-Dependent Kinase Inhibitor Proteins Phase 2
42 GABA Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Neoadjuvant Response-guided Treatment of HER2 Positive Breast Cancer Active, not recruiting NCT02568839 Phase 2, Phase 3 docetaxel + trastuzumab sc + pertuzumab;trastuzumab emtansin
2 Neoadjuvant Response-guided Treatment of Luminal B-type Tumors and Luminal A-type Tumors With Node Metastases Recruiting NCT02603679 Phase 2 Paclitaxel;Tamoxifen + Palbociclib;Aromatase Inhibitor + Palbociclib;Goserelin + Aromatase Inhibitor + Palbociclib
3 Neoadjuvant Response-guided Treatment of Slowly Proliferating Hormone Receptor Positive Tumors Recruiting NCT02592083 Phase 2 Tamoxifen or Aromatase Inhibitor or Aromatase Inhibitor + goserelin;Palbociclib

Search NIH Clinical Center for Breast Sarcoma

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Genetic Tests for Breast Sarcoma

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Anatomical Context for Breast Sarcoma

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MalaCards organs/tissues related to Breast Sarcoma:

42
Breast, Myeloid, Cervix, Bone, Brain, Lymph Node
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Publications for Breast Sarcoma

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Articles related to Breast Sarcoma:

(show top 50) (show all 64)
# Title Authors Year
1
Reconstruction options and outcomes for breast sarcoma patients. ( 31025484 )
2019
2
Impact of Insurance Coverage on Outcomes in Primary Breast Sarcoma. ( 29736143 )
2018
3
The Role of Adjuvant Radiotherapy for a Case of Primary Breast Sarcoma: A Plan Comparison between Three Modern Techniques and a Review of the Literature. ( 29849658 )
2018
4
Advanced Stage Breast Sarcoma Treatment in a Third World Country Public Hospital. ( 30174970 )
2018
5
Imaging findings of primary breast sarcoma: Results of a first multicenter study. ( 28189193 )
2017
6
Pleomorphic Sarcoma of Breast: A Report of Two Cases and Review of Literature. ( 28532141 )
2017
7
Primary breast sarcoma: A retrospective study over 35 years from a single institution. ( 26586158 )
2016
8
Early Local Recurrence Presents Adverse Effect on Outcomes of Primary Breast Sarcoma: A Retrospective Study From Single Institute in China. ( 26735546 )
2016
9
Breast sarcoma. A case report and review of literature. ( 27281361 )
2016
10
Primary female breast sarcoma: clinicopathological features, treatment and prognosis. ( 27510467 )
2016
11
Management of Breast Sarcoma. ( 27542642 )
2016
12
A Scary Onset of a Rare and Aggressive Type of Primary Breast Sarcoma: A Case Report. ( 28101028 )
2016
13
Bilateral Myeloid Sarcoma of Breast in a Young Male Occurring after 11 Years of Chronic Myeloid Leukemia Diagnosis: A Unique Pattern of Relapse. ( 27488267 )
2016
14
Primary Stromal Sarcoma of Breast: A Rare Entity. ( 28974969 )
2016
15
Breast sarcoma: a rare malignancy. ( 24965425 )
2014
16
Spontaneous Perforation as a First Presentation of Ileal Gastrointestinal Stromal Tumour (GIST) with Synchronous Breast Sarcoma. ( 24995213 )
2014
17
Breast sarcoma. ( 23552541 )
2013
18
Breast sarcoma after breast-conserving therapy for breast cancer in a patient with Li-Fraumeni syndrome presenting as focal nonmasslike enhancement on MRI. ( 24261401 )
2013
19
Recurrent phyllodes sarcoma of breast with complete chest wall invasion; a multidisciplinary approach for radical resection. ( 23425565 )
2013
20
Cytologic diagnosis of undifferentiated high grade pleomorphic sarcoma of breast presenting with brain metastasis. ( 23914101 )
2013
21
The CD49d+/high subpopulation from isolated human breast sarcoma spheres possesses tumor-initiating ability. ( 22159714 )
2012
22
Imaging features of primary breast sarcoma. ( 22451578 )
2012
23
Breast sarcoma in a pregnant patient A case report. ( 23070281 )
2012
24
Primary breast sarcoma: prevalence, clinical signs, and radiological features. ( 21565891 )
2011
25
Treatment for breast sarcoma: a large, single-centre series. ( 21628089 )
2011
26
Primary stromal sarcoma of breast with malignant fibrous histiocytoma-like features causing diagnostic dilemma on fine-needle aspiration cytology in a patient with squamous cell carcinoma of cervix: a case report. ( 20607805 )
2011
27
Diagnosis and management of primary breast sarcoma. ( 20480227 )
2010
28
Breast sarcoma--a review of diagnosis and management. ( 19114317 )
2009
29
Primary breast sarcoma. ( 18514698 )
2008
30
Treatment and outcomes of patients with primary breast sarcoma. ( 18723152 )
2008
31
Primary osteogenic sarcoma of breast detected on Tc-99m MIBI scintigraphy and Tc-99m MDP skeletal scintigraphy. ( 18250991 )
2008
32
Periductal stromal sarcoma of breast with lipoblast-like cells: a case report with review of literature. ( 18603698 )
2008
33
Outcome and prognostic factors in breast sarcoma: a multicenter study from the rare cancer network. ( 18023492 )
2007
34
Granulocytic sarcoma of breast: an aleukemic presentation. ( 17337816 )
2007
35
Report on a case of breast sarcoma metastatic to the axillary lymph nodes. ( 16724703 )
2006
36
Good outcome after neoadjuvant chemotherapy and extended surgical resection for a large radiation-induced high-grade breast sarcoma. ( 16824232 )
2006
37
A rare case of breast sarcoma brain metastases. ( 15925991 )
2005
38
Primary breast sarcoma: case report. ( 15490711 )
2004
39
Primary breast sarcoma: clinicopathologic series from the Mayo Clinic and review of the literature. ( 15187996 )
2004
40
Breast sarcoma showing myofibroblastic differentiation. ( 12844261 )
2003
41
Delivery of an anticancer drug and a chemosensitizer to murine breast sarcoma by intratumoral injection of sulfopropyl dextran microspheres. ( 12956895 )
2003
42
P53 expression is a factor for prognostic assessment in breast sarcoma. ( 12002339 )
2002
43
Surgical management of primary breast sarcoma. ( 12206600 )
2002
44
Radiation-induced breast sarcoma. ( 12383902 )
2002
45
An unusual case of metastatic post-irradiation breast sarcoma. ( 14965694 )
2002
46
An analysis of 78 breast sarcoma patients without distant metastases at presentation. ( 10661345 )
2000
47
Stromal sarcoma of breast: a case report. ( 11016187 )
2000
48
F-18 FDG whole-body positron emission tomography scan in primary breast sarcoma. ( 9735983 )
1998
49
Breast sarcoma. ( 8610270 )
1996
50
Human breast sarcoma and human breast implantation: a time trend analysis based on SEER data (1973-1990). ( 7722610 )
1995
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Variations for Breast Sarcoma

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Expression for Breast Sarcoma

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Search GEO for disease gene expression data for Breast Sarcoma.
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Pathways for Breast Sarcoma

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Pathways related to Breast Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Actin Nucleation by ARP-WASP Complex 65
Show member pathways
 12.27 ACTC1 ACTG2 ITGA4
2
ECM-receptor interaction 38
Show member pathways
 11.62 ITGA4 PECAM1
3
Cell adhesion molecules (CAMs) 38
11.49 ITGA4 PECAM1
4
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 11.44 ACTG2 ITGA4 PECAM1
5
Reelin Pathway (Cajal-Retzius cells) 65
11.37 ACTG2 ITGA4
6
G-protein signaling_Regulation of RAC1 activity 23
11.09 ACTG2 ITGA4
7
Cell adhesion_Cadherin-mediated cell adhesion 23
10.56 ACTC1 ACTG2
8
Cytoskeleton remodeling_RalA regulation pathway 23
10.34 ACTC1 ACTG2 ITGA4
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GO Terms for Breast Sarcoma

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Cellular components related to Breast Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.62 ACTC1 ACTG2 ITGA4 PECAM1
2 blood microparticle GO:0072562 9.26 ACTC1 ACTG2
3 cell body GO:0044297 9.16 ACTC1 ACTG2
4 filopodium GO:0030175 8.96 ACTC1 ACTG2
5 cell periphery GO:0071944 8.62 ACTG2 PECAM1

Biological processes related to Breast Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte cell-cell adhesion GO:0007159 9.16 ITGA4 PECAM1
2 mesenchyme migration GO:0090131 8.96 ACTC1 ACTG2
3 diapedesis GO:0050904 8.62 ITGA4 PECAM1
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Sources for Breast Sarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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