Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: BRS061
MIFTS: 35

Breast Sarcoma

Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Breast Sarcoma

About this section

MalaCards integrated aliases for Breast Sarcoma:

Name: Breast Sarcoma 12 15
Sarcoma of Breast 12 74

Classifications:

MalaCards categories:
Global: Cancer diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3017
NCIt 51 C4670
UMLS 74 C0349667
Sources

Summaries for Breast Sarcoma

About this section
Disease Ontology : 12 A breast cancer that has material basis in abnormally proliferating cells derives from mesenchymal cells.

MalaCards based summary : Breast Sarcoma, also known as sarcoma of breast, is related to breast rhabdomyosarcoma and breast leiomyosarcoma. An important gene associated with Breast Sarcoma is ITGA4 (Integrin Subunit Alpha 4), and among its related pathways/superpathways are Actin Nucleation by ARP-WASP Complex and ECM-receptor interaction. The drugs Adenosine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and brain.

Sources

Related Diseases for Breast Sarcoma

About this section

Diseases related to Breast Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 breast rhabdomyosarcoma 11.1
2 breast leiomyosarcoma 11.1
3 breast liposarcoma 11.1
4 breast fibrosarcoma 11.1
5 breast osteosarcoma 11.1
6 breast angiosarcoma 11.0
7 sarcoma 10.5
8 myeloid sarcoma 10.0
9 hydrocele 9.9 ITGA4 PECAM1
10 pulmonary vein stenosis 9.9 ACTC1 PECAM1
11 juvenile nasopharyngeal angiofibroma 9.8 ACTC1 PECAM1
12 osteogenic sarcoma 9.7
13 leukemia 9.7
14 breast fibroadenoma 9.7
15 squamous cell carcinoma 9.7
16 malignant fibroxanthoma 9.7
17 cervix carcinoma 9.7
18 histiocytoma 9.7
19 fibrous histiocytoma 9.7
20 myeloid leukemia 9.7
21 breast cancer 9.7
22 intussusception 9.7
23 li-fraumeni syndrome 9.7
24 li-fraumeni syndrome 2 9.7
25 benign breast phyllodes tumor 9.7
26 myelophthisic anemia 9.7
27 rhabdomyosarcoma 9.7
28 spindle cell sarcoma 9.7
29 hemangioma 9.7 ACTC1 PECAM1

Graphical network of the top 20 diseases related to Breast Sarcoma:



Diseases related to Breast Sarcoma
Sources

Symptoms & Phenotypes for Breast Sarcoma

About this section
Sources

Drugs & Therapeutics for Breast Sarcoma

About this section

Drugs for Breast Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adenosine Approved, Investigational Phase 2, Phase 3 58-61-7 60961
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 6055-19-2, 50-18-0 2907
3
Docetaxel Approved, Investigational Phase 2, Phase 3 114977-28-5 148124
4
Trastuzumab Approved, Investigational Phase 2, Phase 3 180288-69-1 9903
5
Pertuzumab Approved Phase 2, Phase 3 380610-27-5, 145040-37-5 2540
6
Epirubicin Approved Phase 2, Phase 3 56420-45-2 41867
7 Antimitotic Agents Phase 2, Phase 3
8 Ado-trastuzumab emtansine Phase 2, Phase 3
9 Antineoplastic Agents, Immunological Phase 2, Phase 3
10
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
11
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
12
Goserelin Approved Phase 2 65807-02-5 5311128 47725
13
Tamoxifen Approved Phase 2 10540-29-1 2733526
14
Palbociclib Approved, Investigational Phase 2 571190-30-2 11431660 5005498 5330286
15
Phenobarbital Approved, Investigational Phase 2 50-06-6 4763
16
Exemestane Approved, Investigational Phase 2 107868-30-4 60198
17
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
18 Estrogen Receptor Modulators Phase 2
19 GABA Agents Phase 2
20 Protein Kinase Inhibitors Phase 2
21 Estrogens Phase 2
22 Central Nervous System Depressants Phase 2
23 Estrogen Antagonists Phase 2
24 Excitatory Amino Acid Antagonists Phase 2
25 Aromatase Inhibitors Phase 2
26 Antineoplastic Agents, Hormonal Phase 2
27 Steroid Synthesis Inhibitors Phase 2
28 GABA Modulators Phase 2
29 Albumin-Bound Paclitaxel Phase 2
30 Estrogen Receptor Antagonists Phase 2
31 Anticonvulsants Phase 2
32 Neurotransmitter Agents Phase 2
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
34 Antineoplastic Agents, Phytogenic Phase 2
35 Hormones Phase 2
36 Hypnotics and Sedatives Phase 2
37 Cytochrome P-450 CYP3A Inducers Phase 2
38 Excitatory Amino Acids Phase 2
39 Bone Density Conservation Agents Phase 2
40 Hormone Antagonists Phase 2
41 Cyclin-Dependent Kinase Inhibitor Proteins Phase 2
42 Selective Estrogen Receptor Modulators Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Neoadjuvant Response-guided Treatment of HER2 Positive Breast Cancer Active, not recruiting NCT02568839 Phase 2, Phase 3 docetaxel + trastuzumab sc + pertuzumab;trastuzumab emtansin
2 Neoadjuvant Response-guided Treatment of Luminal B-type Tumors and Luminal A-type Tumors With Node Metastases Recruiting NCT02603679 Phase 2 Paclitaxel;Tamoxifen + Palbociclib;Aromatase Inhibitor + Palbociclib;Goserelin + Aromatase Inhibitor + Palbociclib
3 Neoadjuvant Response-guided Treatment of Slowly Proliferating Hormone Receptor Positive Tumors Recruiting NCT02592083 Phase 2 Tamoxifen or Aromatase Inhibitor or Aromatase Inhibitor + goserelin;Palbociclib

Search NIH Clinical Center for Breast Sarcoma

Sources

Genetic Tests for Breast Sarcoma

About this section
Sources

Anatomical Context for Breast Sarcoma

About this section

MalaCards organs/tissues related to Breast Sarcoma:

42
Breast, Bone, Brain, Myeloid, Lymph Node, Cervix
Sources

Publications for Breast Sarcoma

About this section

Articles related to Breast Sarcoma:

(show top 50) (show all 63)
# Title Authors Year
1
The Role of Adjuvant Radiotherapy for a Case of Primary Breast Sarcoma: A Plan Comparison between Three Modern Techniques and a Review of the Literature. ( 29849658 )
2018
2
Impact of Insurance Coverage on Outcomes in Primary Breast Sarcoma. ( 29736143 )
2018
3
Advanced Stage Breast Sarcoma Treatment in a Third World Country Public Hospital. ( 30174970 )
2018
4
Imaging findings of primary breast sarcoma: Results of a first multicenter study. ( 28189193 )
2017
5
Pleomorphic Sarcoma of Breast: A Report of Two Cases and Review of Literature. ( 28532141 )
2017
6
Early Local Recurrence Presents Adverse Effect on Outcomes of Primary Breast Sarcoma: A Retrospective Study From Single Institute in China. ( 26735546 )
2016
7
Management of Breast Sarcoma. ( 27542642 )
2016
8
Primary breast sarcoma: A retrospective study over 35 years from a single institution. ( 26586158 )
2016
9
A Scary Onset of a Rare and Aggressive Type of Primary Breast Sarcoma: A Case Report. ( 28101028 )
2016
10
Bilateral Myeloid Sarcoma of Breast in a Young Male Occurring after 11 Years of Chronic Myeloid Leukemia Diagnosis: A Unique Pattern of Relapse. ( 27488267 )
2016
11
Primary female breast sarcoma: clinicopathological features, treatment and prognosis. ( 27510467 )
2016
12
Breast sarcoma. A case report and review of literature. ( 27281361 )
2016
13
Primary Stromal Sarcoma of Breast: A Rare Entity. ( 28974969 )
2016
14
Spontaneous Perforation as a First Presentation of Ileal Gastrointestinal Stromal Tumour (GIST) with Synchronous Breast Sarcoma. ( 24995213 )
2014
15
Breast sarcoma: a rare malignancy. ( 24965425 )
2014
16
Breast sarcoma after breast-conserving therapy for breast cancer in a patient with Li-Fraumeni syndrome presenting as focal nonmasslike enhancement on MRI. ( 24261401 )
2013
17
Breast sarcoma. ( 23552541 )
2013
18
Cytologic diagnosis of undifferentiated high grade pleomorphic sarcoma of breast presenting with brain metastasis. ( 23914101 )
2013
19
Recurrent phyllodes sarcoma of breast with complete chest wall invasion; a multidisciplinary approach for radical resection. ( 23425565 )
2013
20
Breast sarcoma in a pregnant patient A case report. ( 23070281 )
2012
21
Imaging features of primary breast sarcoma. ( 22451578 )
2012
22
The CD49d+/high subpopulation from isolated human breast sarcoma spheres possesses tumor-initiating ability. ( 22159714 )
2012
23
Primary stromal sarcoma of breast with malignant fibrous histiocytoma-like features causing diagnostic dilemma on fine-needle aspiration cytology in a patient with squamous cell carcinoma of cervix: a case report. ( 20607805 )
2011
24
Primary breast sarcoma: prevalence, clinical signs, and radiological features. ( 21565891 )
2011
25
Treatment for breast sarcoma: a large, single-centre series. ( 21628089 )
2011
26
Diagnosis and management of primary breast sarcoma. ( 20480227 )
2010
27
Breast sarcoma--a review of diagnosis and management. ( 19114317 )
2009
28
Primary breast sarcoma. ( 18514698 )
2008
29
Treatment and outcomes of patients with primary breast sarcoma. ( 18723152 )
2008
30
Primary osteogenic sarcoma of breast detected on Tc-99m MIBI scintigraphy and Tc-99m MDP skeletal scintigraphy. ( 18250991 )
2008
31
Periductal stromal sarcoma of breast with lipoblast-like cells: a case report with review of literature. ( 18603698 )
2008
32
Granulocytic sarcoma of breast: an aleukemic presentation. ( 17337816 )
2007
33
Outcome and prognostic factors in breast sarcoma: a multicenter study from the rare cancer network. ( 18023492 )
2007
34
Good outcome after neoadjuvant chemotherapy and extended surgical resection for a large radiation-induced high-grade breast sarcoma. ( 16824232 )
2006
35
Report on a case of breast sarcoma metastatic to the axillary lymph nodes. ( 16724703 )
2006
36
A rare case of breast sarcoma brain metastases. ( 15925991 )
2005
37
Primary breast sarcoma: case report. ( 15490711 )
2004
38
Primary breast sarcoma: clinicopathologic series from the Mayo Clinic and review of the literature. ( 15187996 )
2004
39
Delivery of an anticancer drug and a chemosensitizer to murine breast sarcoma by intratumoral injection of sulfopropyl dextran microspheres. ( 12956895 )
2003
40
Breast sarcoma showing myofibroblastic differentiation. ( 12844261 )
2003
41
Surgical management of primary breast sarcoma. ( 12206600 )
2002
42
P53 expression is a factor for prognostic assessment in breast sarcoma. ( 12002339 )
2002
43
An unusual case of metastatic post-irradiation breast sarcoma. ( 14965694 )
2002
44
Radiation-induced breast sarcoma. ( 12383902 )
2002
45
An analysis of 78 breast sarcoma patients without distant metastases at presentation. ( 10661345 )
2000
46
Stromal sarcoma of breast: a case report. ( 11016187 )
2000
47
F-18 FDG whole-body positron emission tomography scan in primary breast sarcoma. ( 9735983 )
1998
48
Breast sarcoma. ( 8610270 )
1996
49
Human breast sarcoma and human breast implantation: a time trend analysis based on SEER data (1973-1990). ( 7722610 )
1995
50
High-dose interferon-beta in treatment of spindle-cell sarcoma of breast. ( 2145946 )
1990
Sources

Variations for Breast Sarcoma

About this section
Sources

Expression for Breast Sarcoma

About this section
Search GEO for disease gene expression data for Breast Sarcoma.
Sources

Pathways for Breast Sarcoma

About this section

Pathways related to Breast Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Actin Nucleation by ARP-WASP Complex 65
Show member pathways
 12.27 ACTC1 ACTG2 ITGA4
2
ECM-receptor interaction 38
Show member pathways
 11.61 ITGA4 PECAM1
3
Cell adhesion molecules (CAMs) 38
11.48 ITGA4 PECAM1
4
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 23
Show member pathways
 11.44 ACTG2 ITGA4 PECAM1
5
Reelin Pathway (Cajal-Retzius cells) 65
11.37 ACTG2 ITGA4
6
G-protein signaling_Regulation of RAC1 activity 23
11.09 ACTG2 ITGA4
7
Cell adhesion_Cadherin-mediated cell adhesion 23
10.56 ACTC1 ACTG2
8
Cytoskeleton remodeling_RalA regulation pathway 23
10.34 ACTC1 ACTG2 ITGA4
Sources

GO Terms for Breast Sarcoma

About this section

Cellular components related to Breast Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.62 ACTC1 ACTG2 ITGA4 PECAM1
2 blood microparticle GO:0072562 9.26 ACTC1 ACTG2
3 cell body GO:0044297 9.16 ACTC1 ACTG2
4 filopodium GO:0030175 8.96 ACTC1 ACTG2
5 cell periphery GO:0071944 8.62 ACTG2 PECAM1

Biological processes related to Breast Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte cell-cell adhesion GO:0007159 9.16 ITGA4 PECAM1
2 mesenchyme migration GO:0090131 8.96 ACTC1 ACTG2
3 diapedesis GO:0050904 8.62 ITGA4 PECAM1
Sources

Sources for Breast Sarcoma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....