MCID: BRS061
MIFTS: 32

Breast Sarcoma

Categories: Cancer diseases

Aliases & Classifications for Breast Sarcoma

MalaCards integrated aliases for Breast Sarcoma:

Name: Breast Sarcoma 12 15
Sarcoma of Breast 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3017
NCIt 50 C4670
SNOMED-CT 67 278050001
UMLS 71 C0349667

Summaries for Breast Sarcoma

Disease Ontology : 12 A breast cancer that has material basis in abnormally proliferating cells derives from mesenchymal cells.

MalaCards based summary : Breast Sarcoma, also known as sarcoma of breast, is related to breast osteosarcoma and benign breast phyllodes tumor. An important gene associated with Breast Sarcoma is ITGA4 (Integrin Subunit Alpha 4), and among its related pathways/superpathways are Cell adhesion molecules and MAPK Pathway. Affiliated tissues include breast, myeloid and whole blood, and related phenotypes are cardiovascular system and immune system

Related Diseases for Breast Sarcoma

Diseases related to Breast Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 355)
# Related Disease Score Top Affiliating Genes
1 breast osteosarcoma 30.4 PGR MYOG MME KRT5 ERBB2
2 benign breast phyllodes tumor 30.2 PGR MME CD34
3 embryonal sarcoma 30.0 TP53 MYOG
4 malignant mesenchymoma 30.0 MYOG CD34
5 liposarcoma 30.0 TP53 MYOG CD34
6 cervix carcinoma 29.8 TP53 PGR ERBB2
7 angiosarcoma 29.8 TP53 TIE1 PECAM1 MYOG CD34
8 hemangiopericytoma, malignant 29.7 PECAM1 MYOG CD34
9 myxofibrosarcoma 29.6 TP53 MYOG CD34
10 breast fibroadenoma 29.6 TP53 PGR MME ERBB2
11 malignant peripheral nerve sheath tumor 29.6 TP53 MYOG CD34
12 carcinosarcoma 29.6 TP53 PGR MME ERBB2
13 leiomyosarcoma 29.6 TP53 PGR PECAM1 MYOG
14 gastrointestinal stromal tumor 29.4 TP53 TIE1 ERBB2 CD34
15 breast angiosarcoma 29.1 TIE1 SNRK PECAM1 NETO1 CD34
16 rhabdomyosarcoma 29.1 TP53 MYOG MME ERBB2
17 breast ductal carcinoma 29.1 TP53 PGR KRT5 ERBB2
18 breast disease 29.0 TP53 PGR KRT5 ERBB2
19 breast rhabdomyosarcoma 11.0
20 breast leiomyosarcoma 11.0
21 breast liposarcoma 11.0
22 breast fibrosarcoma 11.0
23 sarcoma 10.6
24 spindle cell sarcoma 10.6
25 glomangioma 10.4 PECAM1 CD34
26 skin epithelioid hemangioma 10.4 PECAM1 CD34
27 aortic malignant tumor 10.4 PECAM1 CD34
28 prostate angiosarcoma 10.4 PECAM1 CD34
29 central nervous system angiosarcoma 10.4 PECAM1 CD34
30 intravascular angioleiomyoma 10.4 PECAM1 CD34
31 central nervous system hemangioma 10.4 PECAM1 CD34
32 heart fibrosarcoma 10.4 PECAM1 CD34
33 ovarian angiosarcoma 10.4 PECAM1 CD34
34 conventional angiosarcoma 10.3 PECAM1 CD34
35 gallbladder leiomyosarcoma 10.3 PECAM1 CD34
36 thyroid sarcoma 10.3 PECAM1 CD34
37 angiomyoma 10.3 PECAM1 CD34
38 eccrine mixed tumor of skin 10.3 PECAM1 ERBB2
39 retroperitoneal hemangiopericytoma 10.3 PECAM1 CD34
40 glomangiosarcoma 10.3 PECAM1 CD34
41 hemangioma of spleen 10.3 PECAM1 CD34
42 intramuscular hemangioma 10.3 PECAM1 CD34
43 colonic lymphangioma 10.3 PECAM1 CD34
44 pulmonary vein leiomyosarcoma 10.3 PGR CD34
45 benign perivascular tumor 10.3 PECAM1 CD34
46 erythema elevatum diutinum 10.3 PECAM1 CD34
47 kaposiform hemangioendothelioma 10.3 PECAM1 CD34
48 lung meningioma 10.3 PGR CD34
49 capillary lymphangioma 10.3 PECAM1 CD34
50 bacillary angiomatosis 10.3 PECAM1 CD34

Graphical network of the top 20 diseases related to Breast Sarcoma:



Diseases related to Breast Sarcoma

Symptoms & Phenotypes for Breast Sarcoma

MGI Mouse Phenotypes related to Breast Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 ERBB2 ITGA4 MME PECAM1 PGR SNRK
2 immune system MP:0005387 9.81 CD34 ITGA4 KRT5 MME PECAM1 PGR
3 integument MP:0010771 9.61 CD34 ERBB2 KRT5 MME MYOG PGR
4 muscle MP:0005369 9.17 ERBB2 MYOG PECAM1 PGR SNRK TIE1

Drugs & Therapeutics for Breast Sarcoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Breast Sarcomas: A Retrospective Analysis of Clinical Features and Outcomes Not yet recruiting NCT04749446

Search NIH Clinical Center for Breast Sarcoma

Genetic Tests for Breast Sarcoma

Anatomical Context for Breast Sarcoma

MalaCards organs/tissues related to Breast Sarcoma:

40
Breast, Myeloid, Whole Blood, Cervix

Publications for Breast Sarcoma

Articles related to Breast Sarcoma:

(show top 50) (show all 159)
# Title Authors PMID Year
1
Chemotherapy and targeted treatments of breast sarcoma by histologic subtype. 61
33554686 2021
2
Angiosarcoma associated with radiation therapy after treatment of breast cancer. Retrospective study on ten years. 61
33487559 2021
3
A need for clarity on surgical management of breast sarcoma: Scottish sarcoma network guidelines and regional audit. 61
33308991 2020
4
Sarcoma of the breast: breast cancer history as etiologic and prognostic factor-A population-based case-control study. 61
32696318 2020
5
Residual Breast Sarcoma Left to Heal by Secondary Intention Following Wide Local Excision: An Unorthodox Approach to a Rare Malignancy. 61
33062546 2020
6
Cowden syndrome is a risk factor for multiple neoplasm: a case report. 61
32807196 2020
7
Radiation-induced undifferentiated pleomorphic sarcoma of the breast. 61
32047082 2020
8
Not Otherwise Specified-Type Sarcoma of Breast with CD10 Expression: Case Report. 61
31620687 2019
9
Neoadjuvant chemotherapy for primary sarcoma of the breast: a case report. 61
31488201 2019
10
Primary Rhabdomyosarcoma of the Breast: Study of Three Cases at One Institution with a Review of Primary Breast Sarcomas. 61
31370385 2019
11
Cluster of Differentiation 10 Positive Stromal Sarcoma of Breast: A Diagnostic Challenge. 61
31523571 2019
12
Breast Sarcomas: Experience of a Reference Center in Colombia. 61
31516788 2019
13
Reconstruction options and outcomes for breast sarcoma patients. 61
31025484 2019
14
Primary Stromal Breast Sarcoma with Concomitant Contralateral Carcinoma: A Rare Case from Syria. 61
31583145 2019
15
Malignant Spindle Cell Tumor Breast-a Diagnostic Dilemma. 61
30288003 2018
16
Sarcomas of the Breast. 61
30005780 2018
17
The presence of glutamate residues on the PAS sequence of the stimuli-sensitive nano-ferritin improves in vivo biodistribution and mitoxantrone encapsulation homogeneity. 61
29474961 2018
18
Contribution of de novo and mosaic TP53 mutations to Li-Fraumeni syndrome. 61
29070607 2018
19
Impact of Insurance Coverage on Outcomes in Primary Breast Sarcoma. 61
29736143 2018
20
The Role of Adjuvant Radiotherapy for a Case of Primary Breast Sarcoma: A Plan Comparison between Three Modern Techniques and a Review of the Literature. 61
29849658 2018
21
Advanced Stage Breast Sarcoma Treatment in a Third World Country Public Hospital. 61
30174970 2018
22
Primary Leiomyosarcoma of Breast Presenting with Metastasis: An Atypical Presentation with Dismal Prognosis. 61
29333025 2017
23
Unusual primary breast cancer - malignant peripheral nerve sheath tumor: a case report and review of the literature. 61
28622765 2017
24
Pleomorphic Sarcoma of Breast: A Report of Two Cases and Review of Literature. 61
28532141 2017
25
Imaging findings of primary breast sarcoma: Results of a first multicenter study. 61
28189193 2017
26
[Primary breast sarcomas: About 30 cases treated at Salah-Azaiez institute in Tunisia]. 61
28223032 2017
27
Breast cancer in patients with Li-Fraumeni syndrome - a case-series study and review of literature. 61
28356770 2017
28
Bilateral Myeloid Sarcoma of Breast in a Young Male Occurring after 11 Years of Chronic Myeloid Leukemia Diagnosis: A Unique Pattern of Relapse. 61
27488267 2016
29
Management of Breast Sarcoma. 61
27542642 2016
30
A Scary Onset of a Rare and Aggressive Type of Primary Breast Sarcoma: A Case Report. 61
28101028 2016
31
Primary female breast sarcoma: clinicopathological features, treatment and prognosis. 61
27510467 2016
32
Defining Action Levels for In Vivo Dosimetry in Intraoperative Electron Radiotherapy. 61
26025385 2016
33
Primary breast sarcoma: A retrospective study over 35 years from a single institution. 61
26586158 2016
34
Sarcoma of the breast: an update on a rare entity. 61
26729013 2016
35
Breast sarcoma. A case report and review of literature. 61
27281361 2016
36
Primary Stromal Sarcoma of Breast: A Rare Entity. 61
28974969 2016
37
Early Local Recurrence Presents Adverse Effect on Outcomes of Primary Breast Sarcoma: A Retrospective Study From Single Institute in China. 61
26735546 2016
38
Phyllodes tumours of the breast: a consensus review. 61
26768026 2016
39
Primary leiomyosarcoma of the breast with prominent osteoclastic giant cells: A case expressing receptor activator of NF-κB ligand (RANKL). 61
26150133 2015
40
Giant cell variant of malignant fibrous histiocytoma of male breast: A rare case report. 61
26458656 2015
41
Angiosarcoma in previously irradiated breast in patient with Li-Fraumeni syndrome. A case report. 61
25271877 2015
42
Comparison of the clinical and prognostic features of primary breast sarcomas and malignant phyllodes tumor. 61
25387733 2015
43
Ventricular tachycardia associated with radiation-induced cardiac sarcoma. 61
25593527 2014
44
Optimal management of sarcomas of the breast: an update. 61
24611696 2014
45
Spontaneous Perforation as a First Presentation of Ileal Gastrointestinal Stromal Tumour (GIST) with Synchronous Breast Sarcoma. 61
24995213 2014
46
Breast sarcoma: a rare malignancy. 61
24965425 2014
47
Primary fibrosarcoma of male breast: a rare entity. 61
24959458 2014
48
Huge primary soft tissue sarcoma of the breast on bone scan. 61
24152643 2014
49
Immediate chest wall reconstruction during pregnancy: surgical management after extended surgical resection due to primary sarcoma of the breast. 61
23827451 2014
50
Breast sarcoma after breast-conserving therapy for breast cancer in a patient with Li-Fraumeni syndrome presenting as focal nonmasslike enhancement on MRI. 61
24261401 2013

Variations for Breast Sarcoma

Expression for Breast Sarcoma

Search GEO for disease gene expression data for Breast Sarcoma.

Pathways for Breast Sarcoma

Pathways related to Breast Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.61 PECAM1 ITGA4 CD34
2
Show member pathways
11.43 TP53 ITGA4 ERBB2
3 11.13 MME ITGA4 CD34
4
Show member pathways
11.11 TP53 TIE1 ITGA4 ERBB2

GO Terms for Breast Sarcoma

Biological processes related to Breast Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 replicative senescence GO:0090399 9.26 TP53 MME
2 paracrine signaling GO:0038001 9.16 PGR CD34
3 diapedesis GO:0050904 8.96 PECAM1 ITGA4
4 glomerular endothelium development GO:0072011 8.62 PECAM1 CD34

Sources for Breast Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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