MCID: BRS042
MIFTS: 30

Breast Scirrhous Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Breast Scirrhous Carcinoma

MalaCards integrated aliases for Breast Scirrhous Carcinoma:

Name: Breast Scirrhous Carcinoma 12 15
Infiltrating Carcinoma of Breast with Fibrotic Stroma 12
Scirrhous Carcinoma of Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7578
NCIt 49 C7362
UMLS 71 C0346151

Summaries for Breast Scirrhous Carcinoma

Disease Ontology : 12 A breast carcinoma that is characterized by the presence of hard, fibrous, particularly invasive tumors in which the malignant cells occur singly or in small clusters or strands in dense connective tissue.

MalaCards based summary : Breast Scirrhous Carcinoma, also known as infiltrating carcinoma of breast with fibrotic stroma, is related to serous cystadenocarcinoma and scirrhous adenocarcinoma. An important gene associated with Breast Scirrhous Carcinoma is PGR (Progesterone Receptor), and among its related pathways/superpathways are Pathways in cancer and Relaxin signaling pathway. Affiliated tissues include breast, ovary and lung, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Breast Scirrhous Carcinoma

Diseases related to Breast Scirrhous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 serous cystadenocarcinoma 10.2 PGR ERBB2
2 scirrhous adenocarcinoma 10.2 PGR ERBB2
3 apocrine adenosis of breast 10.1 PGR ERBB2
4 breast adenoid cystic carcinoma 10.1 PGR ERBB2
5 breast mucinous carcinoma 10.1 PGR ERBB2
6 linitis plastica 10.1 PGR ERBB2
7 apocrine sweat gland neoplasm 10.1 PGR ERBB2
8 recurrent respiratory papillomatosis 10.1 ERBB2 EGFR
9 pleomorphic carcinoma 10.1 PGR EGFR
10 biliary tract cancer 10.1 ERBB2 EGFR
11 paronychia 10.1 ERBB2 EGFR
12 endometrial mucinous adenocarcinoma 10.1 PGR MUC1
13 gastroesophageal junction adenocarcinoma 10.1 ERBB2 EGFR
14 pancreatic mucinous cystadenoma 10.1 PGR MUC1
15 cystadenoma 10.1 PGR MUC1
16 transitional meningioma 10.1 PGR MUC1
17 placental site trophoblastic tumor 10.0 ERBB2 EGFR
18 periampullary adenocarcinoma 10.0 ERBB2 EGFR
19 peritoneum cancer 10.0 ERBB2 EGFR
20 uterine body mixed cancer 10.0 ERBB2 EGFR
21 clear cell meningioma 10.0 PGR MUC1
22 gastroesophageal adenocarcinoma 10.0 ERBB2 EGFR
23 chordoid glioma 10.0 PGR MUC1
24 sclerosing hemangioma 10.0 PGR MUC1
25 malignant peritoneal mesothelioma 10.0 MUC1 EGFR
26 esophagus adenocarcinoma 10.0 ERBB2 EGFR
27 gallbladder adenocarcinoma 10.0 ERBB2 EGFR
28 perivascular epithelioid cell tumor 10.0 PGR MUC1
29 rectum adenocarcinoma 10.0 ERBB2 EGFR
30 meningioma, radiation-induced 10.0 PGR MUC1
31 sertoli-leydig cell tumor 10.0 PGR MUC1
32 hepatoid adenocarcinoma 10.0 MUC1 EGFR
33 sex cord-gonadal stromal tumor 10.0 PGR MUC1
34 chickenpox 10.0 PGR MUC1
35 vulva cancer 10.0 ERBB2 EGFR
36 sertoli cell tumor 10.0 PGR MUC1
37 paget disease, extramammary 10.0 MUC1 ERBB2
38 childhood medulloblastoma 10.0 ERBB2 EGFR
39 exanthem 10.0 ERBB2 EGFR
40 salivary gland disease 10.0 ERBB2 EGFR
41 bartholin's gland adenoid cystic carcinoma 9.9 PGR ESR1
42 bartholin's gland adenoma 9.9 PGR ESR1
43 granulomatous endometritis 9.9 PGR ESR1
44 endometritis 9.9 PGR ESR1
45 signet ring cell adenocarcinoma 9.9 MUC1 ERBB2
46 bartholin's gland benign neoplasm 9.9 PGR ESR1
47 vestibular gland benign neoplasm 9.9 PGR ESR1
48 benign ependymoma 9.9 MUC1 EGFR
49 leiomyomatosis 9.9 PGR ESR1
50 lung leiomyoma 9.9 PGR ESR1

Graphical network of the top 20 diseases related to Breast Scirrhous Carcinoma:



Diseases related to Breast Scirrhous Carcinoma

Symptoms & Phenotypes for Breast Scirrhous Carcinoma

GenomeRNAi Phenotypes related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.7 EGFR
2 Decreased viability GR00221-A-1 9.7 EGFR ESR1
3 Decreased viability GR00221-A-2 9.7 ESR1
4 Decreased viability GR00221-A-3 9.7 ERBB2
5 Decreased viability GR00221-A-4 9.7 EGFR ERBB2 ESR1
6 Decreased viability GR00402-S-2 9.7 EGFR ERBB2 ESR1
7 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.33 EGFR ERBB2 MUC1
8 Decreased viability with paclitaxel GR00179-A-1 8.8 EGFR ERBB2
9 Decreased viability with paclitaxel GR00179-A-3 8.8 EGFR

MGI Mouse Phenotypes related to Breast Scirrhous Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.46 EGFR ERBB2 ESR1 PGR
2 muscle MP:0005369 9.26 EGFR ERBB2 ESR1 PGR
3 neoplasm MP:0002006 8.92 EGFR ERBB2 ESR1 PGR

Drugs & Therapeutics for Breast Scirrhous Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Scirrhous Carcinoma

Genetic Tests for Breast Scirrhous Carcinoma

Anatomical Context for Breast Scirrhous Carcinoma

MalaCards organs/tissues related to Breast Scirrhous Carcinoma:

40
Breast, Ovary, Lung, Prostate, Lymph Node, Eye, Smooth Muscle

Publications for Breast Scirrhous Carcinoma

Articles related to Breast Scirrhous Carcinoma:

# Title Authors PMID Year
1
Establishment and characterization of HER2-positive cell line derived from pleural effusion of human breast scirrhous carcinoma. 61
19067762 2008
2
Establishment and characterization of a cell line (NABCA) derived from metastatic lymph nodes of breast scirrhous carcinoma. 61
17257375 2006
3
[Expression of type I and type III procollagen genes in human scirrhous carcinoma of breast by in situ hybridization]. 61
1337890 1992
4
Scirrhous carcinoma of breast; radical mastectomy. 61
14826032 1951

Variations for Breast Scirrhous Carcinoma

Expression for Breast Scirrhous Carcinoma

Search GEO for disease gene expression data for Breast Scirrhous Carcinoma.

Pathways for Breast Scirrhous Carcinoma

Pathways related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1 12.49 ESR1 ERBB2 EGFR
2
Show member pathways
12.28 PGR ESR1 EGFR
3
Show member pathways
12.27 ESR1 ERBB2 EGFR
4
Show member pathways
12.12 PGR ESR1 ERBB2 EGFR
5
Show member pathways
12.04 MUC1 ERBB2 EGFR
6
Show member pathways
11.82 ESR1 ERBB2 EGFR
7 11.74 ESR1 ERBB2 EGFR
8 11.45 ERBB2 EGFR
9 11.43 ERBB2 EGFR
10
Show member pathways
11.41 ESR1 EGFR
11 11.4 ERBB2 EGFR
12 11.38 ERBB2 EGFR
13 11.36 ESR1 EGFR
14 11.28 ERBB2 EGFR
15 11.16 ESR1 EGFR
16 11.11 ERBB2 EGFR
17
Show member pathways
11.1 ESR1 ERBB2 EGFR
18
Show member pathways
10.96 PGR ESR1 ERBB2 EGFR
19 10.92 ERBB2 EGFR
20 10.88 ERBB2 EGFR

GO Terms for Breast Scirrhous Carcinoma

Cellular components related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.13 MUC1 ERBB2 EGFR
2 basal plasma membrane GO:0009925 8.62 ERBB2 EGFR

Biological processes related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell growth GO:0030307 9.52 ERBB2 EGFR
2 cellular response to growth factor stimulus GO:0071363 9.51 ERBB2 EGFR
3 positive regulation of epithelial cell proliferation GO:0050679 9.49 ERBB2 EGFR
4 positive regulation of MAP kinase activity GO:0043406 9.48 ERBB2 EGFR
5 steroid hormone mediated signaling pathway GO:0043401 9.46 PGR ESR1
6 positive regulation of fibroblast proliferation GO:0048146 9.43 ESR1 EGFR
7 cellular response to epidermal growth factor stimulus GO:0071364 9.4 ERBB2 EGFR
8 cellular response to estradiol stimulus GO:0071392 9.37 ESR1 EGFR
9 regulation of cell motility GO:2000145 9.32 ERBB2 EGFR
10 ERBB2 signaling pathway GO:0038128 9.26 ERBB2 EGFR
11 regulation of ERK1 and ERK2 cascade GO:0070372 9.16 ERBB2 EGFR
12 positive regulation of protein kinase B signaling GO:0051897 9.13 ESR1 ERBB2 EGFR
13 negative regulation of ERBB signaling pathway GO:1901185 8.62 ERBB2 EGFR

Molecular functions related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.61 PGR MUC1 ESR1
2 ATPase binding GO:0051117 9.46 PGR ESR1
3 identical protein binding GO:0042802 9.46 PGR ESR1 ERBB2 EGFR
4 enzyme binding GO:0019899 9.43 PGR ESR1 EGFR
5 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.4 ERBB2 EGFR
6 steroid hormone receptor activity GO:0003707 9.37 PGR ESR1
7 nuclear receptor activity GO:0004879 9.32 PGR ESR1
8 steroid binding GO:0005496 8.96 PGR ESR1
9 nitric-oxide synthase regulator activity GO:0030235 8.62 ESR1 EGFR

Sources for Breast Scirrhous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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