MCID: BRS042
MIFTS: 29

Breast Scirrhous Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Breast Scirrhous Carcinoma

MalaCards integrated aliases for Breast Scirrhous Carcinoma:

Name: Breast Scirrhous Carcinoma 12 15
Infiltrating Carcinoma of Breast with Fibrotic Stroma 12
Scirrhous Carcinoma of Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7578
NCIt 50 C7362
UMLS 72 C0346151

Summaries for Breast Scirrhous Carcinoma

Disease Ontology : 12 A breast carcinoma that is characterized by the presence of hard, fibrous, particularly invasive tumors in which the malignant cells occur singly or in small clusters or strands in dense connective tissue.

MalaCards based summary : Breast Scirrhous Carcinoma, also known as infiltrating carcinoma of breast with fibrotic stroma, is related to breast apocrine carcinoma and scirrhous adenocarcinoma. An important gene associated with Breast Scirrhous Carcinoma is PGR (Progesterone Receptor), and among its related pathways/superpathways are Pathways in cancer and Glioma. Affiliated tissues include breast and lymph node, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Breast Scirrhous Carcinoma

Diseases related to Breast Scirrhous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 breast apocrine carcinoma 10.3 PGR ERBB2
2 scirrhous adenocarcinoma 10.3 PGR ERBB2
3 intracystic papillary adenoma 10.3 PGR ERBB2
4 breast metaplastic carcinoma 10.3 PGR ERBB2
5 uterine body mixed cancer 10.3 PGR ERBB2
6 breast intraductal proliferative lesion 10.2 ERBB2 EGFR
7 breast secretory carcinoma 10.2 PGR ERBB2
8 breast squamous cell carcinoma 10.2 ERBB2 EGFR
9 mixed cell type cancer 10.2 PGR ERBB2
10 bilateral breast cancer 10.2 PGR ERBB2
11 breast mucoepidermoid carcinoma 10.2 PGR MUC1
12 endosalpingiosis 10.2 PGR MUC1
13 clear cell meningioma 10.2 PGR MUC1
14 acneiform dermatitis 10.2 ERBB2 EGFR
15 mucinous adenocarcinoma 10.2 MUC1 EGFR
16 perivascular epithelioid cell tumor 10.2 PGR MUC1
17 sertoli cell tumor 10.1 PGR MUC1
18 mucinous lung adenocarcinoma 10.1 ERBB2 EGFR
19 sclerosing hemangioma 10.1 PGR MUC1
20 gallbladder adenocarcinoma 10.1 ERBB2 EGFR
21 sertoli-leydig cell tumor 10.1 PGR MUC1
22 malignant peritoneal mesothelioma 10.1 MUC1 EGFR
23 dermoid cyst 10.1 PGR MUC1
24 adenosquamous lung carcinoma 10.1 ERBB2 EGFR
25 chickenpox 10.1 PGR MUC1
26 pancreatic mucinous cystadenoma 10.1 PGR MUC1
27 cystadenoma 10.1 PGR MUC1
28 serous cystadenocarcinoma 10.1 PGR ERBB2
29 exanthem 10.1 ERBB2 EGFR
30 hepatoid adenocarcinoma 10.1 MUC1 EGFR
31 paget disease, extramammary 10.1 MUC1 ERBB2
32 ovarian serous cystadenocarcinoma 10.1 PGR ERBB2
33 esophageal disease 10.1 ERBB2 EGFR
34 meningioma, radiation-induced 10.1 PGR MUC1
35 spindle cell carcinoma 10.1 PGR MUC1
36 pneumothorax 10.0 PGR MUC1
37 bartholin's gland adenoma 10.0 PGR ESR1
38 vestibular gland benign neoplasm 10.0 PGR ESR1
39 lung leiomyoma 10.0 PGR ESR1
40 leiomyoma 10.0 PGR ESR1
41 myoma 10.0 PGR ESR1
42 vulvar syringoma 10.0 PGR ESR1
43 vulvar leiomyoma 10.0 PGR ESR1
44 trigonitis 10.0 PGR ESR1
45 vulvar benign neoplasm 10.0 PGR ESR1
46 predominantly cortical thymoma 10.0 PGR ESR1
47 bartholin's gland benign neoplasm 10.0 PGR ESR1
48 cribriform carcinoma 10.0 PGR ESR1
49 endometrial squamous cell carcinoma 10.0 PGR ESR1
50 progesterone resistance 10.0 PGR ESR1

Graphical network of the top 20 diseases related to Breast Scirrhous Carcinoma:



Diseases related to Breast Scirrhous Carcinoma

Symptoms & Phenotypes for Breast Scirrhous Carcinoma

GenomeRNAi Phenotypes related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.7 EGFR
2 Decreased viability GR00221-A-1 9.7 EGFR ESR1
3 Decreased viability GR00221-A-2 9.7 ESR1
4 Decreased viability GR00221-A-3 9.7 ERBB2
5 Decreased viability GR00221-A-4 9.7 EGFR ERBB2 ESR1
6 Decreased viability GR00402-S-2 9.7 EGFR ERBB2 ESR1
7 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.33 EGFR ERBB2 MUC1
8 Decreased viability with paclitaxel GR00179-A-1 8.8 EGFR ERBB2
9 Decreased viability with paclitaxel GR00179-A-3 8.8 EGFR

MGI Mouse Phenotypes related to Breast Scirrhous Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.62 EGFR ERBB2 ESR1 PGR
2 integument MP:0010771 9.56 EGFR ERBB2 ESR1 PGR
3 limbs/digits/tail MP:0005371 9.46 EGFR ERBB2 ESR1 PGR
4 muscle MP:0005369 9.26 EGFR ERBB2 ESR1 PGR
5 neoplasm MP:0002006 8.92 EGFR ERBB2 ESR1 PGR

Drugs & Therapeutics for Breast Scirrhous Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Scirrhous Carcinoma

Genetic Tests for Breast Scirrhous Carcinoma

Anatomical Context for Breast Scirrhous Carcinoma

MalaCards organs/tissues related to Breast Scirrhous Carcinoma:

41
Breast, Lymph Node

Publications for Breast Scirrhous Carcinoma

Articles related to Breast Scirrhous Carcinoma:

# Title Authors PMID Year
1
Establishment and characterization of HER2-positive cell line derived from pleural effusion of human breast scirrhous carcinoma. 38
19067762 2008
2
Establishment and characterization of a cell line (NABCA) derived from metastatic lymph nodes of breast scirrhous carcinoma. 38
17257375 2006
3
[Expression of type I and type III procollagen genes in human scirrhous carcinoma of breast by in situ hybridization]. 38
1337890 1992
4
Scirrhous carcinoma of breast; radical mastectomy. 38
14826032 1951

Variations for Breast Scirrhous Carcinoma

Expression for Breast Scirrhous Carcinoma

Search GEO for disease gene expression data for Breast Scirrhous Carcinoma.

Pathways for Breast Scirrhous Carcinoma

Pathways related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1 12.48 ESR1 ERBB2 EGFR
2
Show member pathways
12.27 ESR1 ERBB2 EGFR
3
Show member pathways
12.12 PGR ESR1 ERBB2 EGFR
4
Show member pathways
11.82 ESR1 ERBB2 EGFR
5 11.74 ESR1 ERBB2 EGFR
6
Show member pathways
11.54 PGR ESR1
7 11.43 ERBB2 EGFR
8 11.41 ERBB2 EGFR
9
Show member pathways
11.39 ESR1 EGFR
10 11.37 ERBB2 EGFR
11 11.35 ERBB2 EGFR
12 11.34 ESR1 EGFR
13 11.23 ERBB2 EGFR
14 11.14 ESR1 EGFR
15
Show member pathways
11.1 ESR1 ERBB2 EGFR
16 11.09 ERBB2 EGFR
17
Show member pathways
10.96 PGR ESR1 ERBB2 EGFR
18 10.9 ERBB2 EGFR
19 10.85 ERBB2 EGFR

GO Terms for Breast Scirrhous Carcinoma

Cellular components related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basal plasma membrane GO:0009925 8.96 ERBB2 EGFR
2 apical plasma membrane GO:0016324 8.8 MUC1 ERBB2 EGFR

Biological processes related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.84 PGR ESR1 ERBB2 EGFR
2 positive regulation of cell growth GO:0030307 9.52 ERBB2 EGFR
3 positive regulation of MAP kinase activity GO:0043406 9.51 ERBB2 EGFR
4 positive regulation of epithelial cell proliferation GO:0050679 9.49 ERBB2 EGFR
5 cellular response to growth factor stimulus GO:0071363 9.48 ERBB2 EGFR
6 steroid hormone mediated signaling pathway GO:0043401 9.46 PGR ESR1
7 positive regulation of fibroblast proliferation GO:0048146 9.43 ESR1 EGFR
8 cellular response to epidermal growth factor stimulus GO:0071364 9.4 ERBB2 EGFR
9 cellular response to estradiol stimulus GO:0071392 9.37 ESR1 EGFR
10 regulation of cell motility GO:2000145 9.32 ERBB2 EGFR
11 ERBB2 signaling pathway GO:0038128 9.26 ERBB2 EGFR
12 regulation of ERK1 and ERK2 cascade GO:0070372 9.16 ERBB2 EGFR
13 positive regulation of protein kinase B signaling GO:0051897 9.13 ESR1 ERBB2 EGFR
14 negative regulation of ERBB signaling pathway GO:1901185 8.62 ERBB2 EGFR

Molecular functions related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.61 PGR MUC1 ESR1
2 protein phosphatase binding GO:0019903 9.48 ERBB2 EGFR
3 ATPase binding GO:0051117 9.46 PGR ESR1
4 identical protein binding GO:0042802 9.46 PGR ESR1 ERBB2 EGFR
5 enzyme binding GO:0019899 9.43 PGR ESR1 EGFR
6 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.4 ERBB2 EGFR
7 steroid hormone receptor activity GO:0003707 9.37 PGR ESR1
8 nuclear receptor activity GO:0004879 9.32 PGR ESR1
9 steroid binding GO:0005496 8.96 PGR ESR1
10 nitric-oxide synthase regulator activity GO:0030235 8.62 ESR1 EGFR

Sources for Breast Scirrhous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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