MCID: BRS042
MIFTS: 34

Breast Scirrhous Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Breast Scirrhous Carcinoma

MalaCards integrated aliases for Breast Scirrhous Carcinoma:

Name: Breast Scirrhous Carcinoma 12 15
Infiltrating Carcinoma of Breast with Fibrotic Stroma 12
Scirrhous Carcinoma of Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7578
NCIt 51 C7362
UMLS 74 C0346151

Summaries for Breast Scirrhous Carcinoma

Disease Ontology : 12 A breast carcinoma that is characterized by the presence of hard, fibrous, particularly invasive tumors in which the malignant cells occur singly or in small clusters or strands in dense connective tissue.

MalaCards based summary : Breast Scirrhous Carcinoma, also known as infiltrating carcinoma of breast with fibrotic stroma, is related to scirrhous adenocarcinoma and breast apocrine carcinoma. An important gene associated with Breast Scirrhous Carcinoma is PGR (Progesterone Receptor), and among its related pathways/superpathways are Pathways in cancer and Glioma. Affiliated tissues include breast, lung and ovary, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Breast Scirrhous Carcinoma

Diseases related to Breast Scirrhous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 scirrhous adenocarcinoma 10.2 ERBB2 PGR
2 breast apocrine carcinoma 10.2 ERBB2 PGR
3 intracystic papillary adenoma 10.2 ERBB2 PGR
4 breast metaplastic carcinoma 10.2 ERBB2 PGR
5 uterine body mixed cancer 10.2 ERBB2 PGR
6 breast intraductal proliferative lesion 10.2 EGFR ERBB2
7 breast secretory carcinoma 10.1 ERBB2 PGR
8 breast squamous cell carcinoma 10.1 EGFR ERBB2
9 mixed cell type cancer 10.1 ERBB2 PGR
10 breast mucoepidermoid carcinoma 10.1 MUC1 PGR
11 bilateral breast cancer 10.1 ERBB2 PGR
12 endosalpingiosis 10.1 MUC1 PGR
13 clear cell meningioma 10.1 MUC1 PGR
14 mucinous adenocarcinoma 10.1 EGFR MUC1
15 acneiform dermatitis 10.1 EGFR ERBB2
16 perivascular epithelioid cell tumor 10.1 MUC1 PGR
17 sertoli cell tumor 10.1 MUC1 PGR
18 mucinous lung adenocarcinoma 10.1 EGFR ERBB2
19 dermoid cyst 10.1 MUC1 PGR
20 sertoli-leydig cell tumor 10.1 MUC1 PGR
21 gallbladder adenocarcinoma 10.1 EGFR ERBB2
22 sclerosing hemangioma 10.1 MUC1 PGR
23 malignant peritoneal mesothelioma 10.1 EGFR MUC1
24 adenosquamous lung carcinoma 10.1 EGFR ERBB2
25 pancreatic mucinous cystadenoma 10.1 MUC1 PGR
26 cystadenoma 10.1 MUC1 PGR
27 chickenpox 10.1 MUC1 PGR
28 serous cystadenocarcinoma 10.1 ERBB2 PGR
29 exanthem 10.1 EGFR ERBB2
30 hepatoid adenocarcinoma 10.1 EGFR MUC1
31 paget disease, extramammary 10.1 ERBB2 MUC1
32 ovarian serous cystadenocarcinoma 10.1 ERBB2 PGR
33 esophageal disease 10.0 EGFR ERBB2
34 meningioma, radiation-induced 10.0 MUC1 PGR
35 spindle cell carcinoma 10.0 MUC1 PGR
36 pneumothorax 10.0 MUC1 PGR
37 vestibular gland benign neoplasm 10.0 ESR1 PGR
38 bartholin's gland adenoma 10.0 ESR1 PGR
39 vulvar syringoma 10.0 ESR1 PGR
40 lung leiomyoma 10.0 ESR1 PGR
41 leiomyoma 10.0 ESR1 PGR
42 myoma 10.0 ESR1 PGR
43 vulvar benign neoplasm 10.0 ESR1 PGR
44 trigonitis 10.0 ESR1 PGR
45 vulvar leiomyoma 10.0 ESR1 PGR
46 predominantly cortical thymoma 10.0 ESR1 PGR
47 bartholin's gland benign neoplasm 10.0 ESR1 PGR
48 progesterone resistance 10.0 ESR1 PGR
49 endometrial squamous cell carcinoma 10.0 ESR1 PGR
50 cribriform carcinoma 10.0 ESR1 PGR

Graphical network of the top 20 diseases related to Breast Scirrhous Carcinoma:



Diseases related to Breast Scirrhous Carcinoma

Symptoms & Phenotypes for Breast Scirrhous Carcinoma

GenomeRNAi Phenotypes related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.7 EGFR
2 Decreased viability GR00221-A-1 9.7 EGFR ESR1
3 Decreased viability GR00221-A-2 9.7 ESR1
4 Decreased viability GR00221-A-3 9.7 ERBB2
5 Decreased viability GR00221-A-4 9.7 EGFR ERBB2 ESR1
6 Decreased viability GR00402-S-2 9.7 EGFR ERBB2 ESR1
7 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.33 EGFR ERBB2 MUC1
8 Decreased viability with paclitaxel GR00179-A-1 8.8 EGFR ERBB2
9 Decreased viability with paclitaxel GR00179-A-3 8.8 EGFR

MGI Mouse Phenotypes related to Breast Scirrhous Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.62 EGFR ERBB2 ESR1 PGR
2 integument MP:0010771 9.56 EGFR ERBB2 ESR1 PGR
3 limbs/digits/tail MP:0005371 9.46 EGFR ERBB2 ESR1 PGR
4 muscle MP:0005369 9.26 EGFR ERBB2 ESR1 PGR
5 neoplasm MP:0002006 8.92 EGFR ERBB2 ESR1 PGR

Drugs & Therapeutics for Breast Scirrhous Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Scirrhous Carcinoma

Genetic Tests for Breast Scirrhous Carcinoma

Anatomical Context for Breast Scirrhous Carcinoma

MalaCards organs/tissues related to Breast Scirrhous Carcinoma:

42
Breast, Lung, Ovary, Lymph Node, Colon, Bone, Smooth Muscle

Publications for Breast Scirrhous Carcinoma

Articles related to Breast Scirrhous Carcinoma:

# Title Authors Year
1
Establishment and characterization of HER2-positive cell line derived from pleural effusion of human breast scirrhous carcinoma. ( 19067762 )
2008
2
Establishment and characterization of a cell line (NABCA) derived from metastatic lymph nodes of breast scirrhous carcinoma. ( 17257375 )
2006

Variations for Breast Scirrhous Carcinoma

Expression for Breast Scirrhous Carcinoma

Search GEO for disease gene expression data for Breast Scirrhous Carcinoma.

Pathways for Breast Scirrhous Carcinoma

Pathways related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1 12.48 EGFR ERBB2 ESR1
2
Show member pathways
12.28 EGFR ERBB2 ESR1
3
Show member pathways
12.12 EGFR ERBB2 ESR1 PGR
4
Show member pathways
12.09 EGFR ERBB2 MUC1
5
Show member pathways
11.82 EGFR ERBB2 ESR1
6 11.74 EGFR ERBB2 ESR1
7
Show member pathways
11.55 ESR1 PGR
8 11.44 EGFR ERBB2
9 11.42 EGFR ERBB2
10
Show member pathways
11.4 EGFR ESR1
11 11.38 EGFR ERBB2
12 11.36 EGFR ESR1
13 11.34 EGFR ERBB2
14 11.25 EGFR ERBB2
15 11.16 EGFR ESR1
16 11.11 EGFR ERBB2
17
Show member pathways
11.1 EGFR ERBB2 ESR1
18
Show member pathways
10.96 EGFR ERBB2 ESR1 PGR
19 10.9 EGFR ERBB2
20 10.85 EGFR ERBB2

GO Terms for Breast Scirrhous Carcinoma

Cellular components related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.13 EGFR ERBB2 MUC1
2 basal plasma membrane GO:0009925 8.62 EGFR ERBB2

Biological processes related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.84 EGFR ERBB2 ESR1 PGR
2 positive regulation of cell growth GO:0030307 9.52 EGFR ERBB2
3 positive regulation of epithelial cell proliferation GO:0050679 9.51 EGFR ERBB2
4 positive regulation of MAP kinase activity GO:0043406 9.49 EGFR ERBB2
5 cellular response to growth factor stimulus GO:0071363 9.48 EGFR ERBB2
6 positive regulation of fibroblast proliferation GO:0048146 9.46 EGFR ESR1
7 steroid hormone mediated signaling pathway GO:0043401 9.43 ESR1 PGR
8 cellular response to epidermal growth factor stimulus GO:0071364 9.4 EGFR ERBB2
9 cellular response to estradiol stimulus GO:0071392 9.37 EGFR ESR1
10 ERBB2 signaling pathway GO:0038128 9.32 EGFR ERBB2
11 regulation of cell motility GO:2000145 9.26 EGFR ERBB2
12 regulation of ERK1 and ERK2 cascade GO:0070372 9.16 EGFR ERBB2
13 positive regulation of protein kinase B signaling GO:0051897 9.13 EGFR ERBB2 ESR1
14 negative regulation of ERBB signaling pathway GO:1901185 8.62 EGFR ERBB2

Molecular functions related to Breast Scirrhous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.61 ESR1 MUC1 PGR
2 protein phosphatase binding GO:0019903 9.48 EGFR ERBB2
3 ATPase binding GO:0051117 9.46 ESR1 PGR
4 identical protein binding GO:0042802 9.46 EGFR ERBB2 ESR1 PGR
5 enzyme binding GO:0019899 9.43 EGFR ESR1 PGR
6 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.4 EGFR ERBB2
7 steroid hormone receptor activity GO:0003707 9.37 ESR1 PGR
8 nuclear receptor activity GO:0004879 9.32 ESR1 PGR
9 steroid binding GO:0005496 8.96 ESR1 PGR
10 nitric-oxide synthase regulator activity GO:0030235 8.62 EGFR ESR1

Sources for Breast Scirrhous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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