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SBC
MCID: BRS062
MIFTS: 37

Breast Secretory Carcinoma (SBC)

Categories: Cancer diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Breast Secretory Carcinoma

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MalaCards integrated aliases for Breast Secretory Carcinoma:

Name: Breast Secretory Carcinoma 12 15
Secretory Breast Carcinoma 53 44 72
Juvenile Secretory Carcinoma of Breast 12
Secretory Carcinoma of the Breast 53
Juvenile Carcinoma of the Breast 12
Juvenile Breast Carcinoma 12
Sbc 53

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
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External Ids:

Disease Ontology 12 DOID:4922
MeSH 44 C537535
NCIt 50 C4189
SNOMED-CT 68 41919003
UMLS 72 C0334371
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Summaries for Breast Secretory Carcinoma

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NIH Rare Diseases : 53 Secretory breast carcinoma (SBC) is a very rare, slow-growing type of breast cancer. It was originally referred to as "juvenile breast carcinoma" because it was first recognized in children and adolescents. However, many cases reported in the last several decades have occurred in adults of all ages. SBC may occur in males or females but like other types of breast cancer, it is much more common in females. Signs and symptoms of SBC most commonly include a painless, firm mass in the breast, which may move when palpated. Some people with SBC also have nipple discharge. There is currently no consensus regarding treatment for SBC, and treatment options may depend on the person's age and the size of the tumor. Options may include surgery to remove the tumor or breast (mastectomy), surgery to also remove nearby lymph nodes, radiotherapy, and chemotherapy. SBC may recur in some cases, but when this happens, it is often in the same area of the breast and after a long period of time (called a late local recurrence). SBC is usually associated with an excellent prognosis (prolonged survival), even when it spreads (metastasizes) to the lymph nodes. The risk for SBC to spread to other parts of the body is thought to be extremely low.

MalaCards based summary : Breast Secretory Carcinoma, also known as secretory breast carcinoma, is related to breast cystic hypersecretory carcinoma and papilloma, and has symptoms including pain An important gene associated with Breast Secretory Carcinoma is NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3), and among its related pathways/superpathways are Cytoskeletal Signaling and MAPK Signaling: Mitogen Stimulation Pathway. Affiliated tissues include breast, lymph node and salivary gland, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Disease Ontology : 12 A breast adenocarcinoma that has material basis in cells with abundant granular or clear vacuolated cytoplasm.

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Related Diseases for Breast Secretory Carcinoma

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Diseases related to Breast Secretory Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 breast cystic hypersecretory carcinoma 31.8 TG LALBA KRT5 ERBB2
2 papilloma 30.5 KRT8 KRT7 KRT5
3 in situ carcinoma 30.2 PGR KRT5 ERBB2
4 pregnancy adenoma 30.2 KRT8 KRT7 KRT5
5 breast ductal carcinoma 30.1 PGR KRT8 ERBB2
6 tubular adenocarcinoma 29.7 PGR MUC1 ERBB2
7 papillary carcinoma 28.6 TG PGR MUC1 KRT7 ERBB2
8 neural tube defects 11.4
9 adult mesoblastic nephroma 10.8 NTRK3 ETV6
10 primary hypereosinophilic syndrome 10.7 FGFR1 ETV6
11 breast osteosarcoma 10.6 KRT8 ERBB2
12 pediatric fibrosarcoma 10.6 NTRK3 ETV6
13 breast apocrine carcinoma 10.5 PGR ERBB2
14 scirrhous adenocarcinoma 10.5 PGR ERBB2
15 inverted transitional papilloma 10.5 KRT7 KRT5
16 ceruminoma 10.5 KRT7 KRT5
17 glassy cell carcinoma of the cervix 10.5 PGR ERBB2
18 benign breast adenomyoepithelioma 10.5 KRT7 KRT5
19 balloon cell malignant melanoma 10.5 KRT7 KRT5
20 malignant spiradenoma 10.5 KRT7 KRT5
21 intracystic papillary adenoma 10.5 PGR ERBB2
22 benign mesothelioma 10.5 KRT7 KRT5
23 proliferating trichilemmal cyst 10.5 KRT8 KRT7
24 breast medullary carcinoma 10.5 PGR ERBB2
25 endolymphatic sac tumor 10.5 KRT8 KRT7
26 progesterone-receptor negative breast cancer 10.4 PGR ERBB2
27 sensory organ benign neoplasm 10.4 KRT7 KRT5
28 breast squamous cell carcinoma 10.4 KRT5 ERBB2
29 large cell acanthoma 10.4 KRT7 KRT5
30 eccrine papillary adenocarcinoma 10.4 PGR KRT7
31 lymphoepithelioma-like thymic carcinoma 10.4 TG KRT5
32 progesterone-receptor positive breast cancer 10.4 PGR ERBB2
33 cervical clear cell adenocarcinoma 10.4 PGR KRT8 KRT5
34 adenoid squamous cell carcinoma 10.4 KRT8 KRT7
35 differentiated thyroid carcinoma 10.4 TG NTRK3 ETV6
36 oncocytic breast carcinoma 10.4 PGR KRT7
37 breast metaplastic carcinoma 10.3 PGR KRT5 ERBB2
38 benign metastasizing leiomyoma 10.3 PGR KRT7
39 ovarian germ cell teratoma 10.3 TG KRT7
40 thoracic benign neoplasm 10.3 PGR KRT5 ERBB2
41 breast benign neoplasm 10.3 PGR KRT5 ERBB2
42 cribriform carcinoma 10.3 PGR KRT7
43 chronic ethmoiditis 10.3 MUC4 MUC1
44 malignant mesenchymoma 10.3 NTRK3 ETV6 CDK4
45 pre-malignant neoplasm 10.3 PGR KRT5 ERBB2
46 prostate squamous cell carcinoma 10.3 KRT8 KRT7 KRT5
47 nasal cavity squamous cell carcinoma 10.3 KRT8 KRT7 KRT5
48 atypical choroid plexus papilloma 10.3 KRT8 KRT7 KRT5
49 ovarian germ cell cancer 10.3 TG KRT7
50 hidrocystoma 10.3 SOX10 KRT8 KRT7

Graphical network of the top 20 diseases related to Breast Secretory Carcinoma:



Diseases related to Breast Secretory Carcinoma
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Symptoms & Phenotypes for Breast Secretory Carcinoma

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UMLS symptoms related to Breast Secretory Carcinoma:


pain

MGI Mouse Phenotypes related to Breast Secretory Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.07 CDK4 CISH ERBB2 ETV6 FGFR1 LALBA
2 growth/size/body region MP:0005378 10.06 CDK4 ERBB2 ETV6 FGFR1 KRT5 KRT8
3 homeostasis/metabolism MP:0005376 10.03 CDK4 CISH ERBB2 ETV6 FGFR1 KRT7
4 digestive/alimentary MP:0005381 10.01 CDK4 ERBB2 ETV6 FGFR1 KRT5 KRT8
5 integument MP:0010771 9.81 CDK4 ERBB2 ETV6 FGFR1 KRT5 LALBA
6 limbs/digits/tail MP:0005371 9.43 ERBB2 FGFR1 KRT5 PGR SOX10 TG
7 normal MP:0002873 9.28 CDK4 ERBB2 ETV6 FGFR1 LALBA NTRK3
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Drugs & Therapeutics for Breast Secretory Carcinoma

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Search Clinical Trials , NIH Clinical Center for Breast Secretory Carcinoma

Cochrane evidence based reviews: secretory breast carcinoma

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Genetic Tests for Breast Secretory Carcinoma

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Anatomical Context for Breast Secretory Carcinoma

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MalaCards organs/tissues related to Breast Secretory Carcinoma:

41
Breast, Lymph Node, Salivary Gland, Testes, Thyroid, Liver, Myeloid
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Publications for Breast Secretory Carcinoma

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Articles related to Breast Secretory Carcinoma:

(show top 50) (show all 67)
# Title Authors PMID Year
1
Rare breast cancer: 246 invasive secretory carcinomas from the National Cancer Data Base. 38 6
27040042 2016
2
Secretory breast carcinoma: a clinicopathological and immunophenotypic study of 15 cases with a review of the literature. 38 6
22157932 2012
3
[Clinicopathologic features of secretory breast carcinoma]. 38
31434456 2019
4
Pan-Trk immunohistochemistry reliably identifies ETV6-NTRK3 fusion in secretory carcinoma of the salivary gland. 38
31423558 2019
5
Neurotrophic tropomyosin or tyrosine receptor kinase (NTRK) genes. 38
30636697 2019
6
Clinicopathologic and molecular characteristics of 44 patients with pure secretory breast carcinoma. 38
31119054 2019
7
Secretory carcinoma of the breast: A case report. 38
30852371 2019
8
Molecular characterization of cancers with NTRK gene fusions. 38
30171197 2019
9
Secretory Carcinoma of the Parotid: Making the Correct Diagnosis of a Rare Salivary Gland Carcinoma When Molecular Biology Testing Is Not Available. 38
31007960 2019
10
Secretory Carcinoma of the Thyroid Gland: Report of a Highly Aggressive Case Clinically Mimicking Undifferentiated Carcinoma and Review of the Literature. 38
30564997 2018
11
Secretory breast carcinoma in an 8-year-old girl: A case report and literature review. 38
30251458 2018
12
Secretory Carcinoma of the Breast in a 20-year-old Male: Case Report and Review of Literature. 38
30283227 2018
13
Novel identification of STAT1 as a crucial mediator of ETV6-NTRK3-induced tumorigenesis. 38
29391602 2018
14
Recurrent EML4-NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy. 38
29099503 2018
15
Primary cutaneous secretory carcinoma: A previously overlooked low-grade sweat gland carcinoma. 38
29205457 2018
16
Mammary Analogue Secretory Carcinoma of Minor Salivary Glands: A Rare Case Series and Review of the Literature. 38
29531003 2018
17
Secretory breast carcinoma with a papillary-predominant pattern: an unusual morphological variant. 38
28383794 2017
18
Genomic profiling of breast secretory carcinomas reveals distinct genetics from other breast cancers and similarity to mammary analog secretory carcinomas. 38
28548128 2017
19
Cytologic findings of mammary analogue secretory carcinoma arising in the thyroid. 38
28251831 2017
20
Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Salivary Gland. 38
28247227 2017
21
[Secretory breast carcinoma with liver metastatic: report of a case]. 38
28173678 2017
22
Successful Targeted Therapy of Refractory Pediatric ETV6-NTRK3 Fusion-Positive Secretory Breast Carcinoma. 38
29623306 2017
23
Secretory Carcinoma in a 79- Year-Old Woman: An Exceptionally Rare Type of Breast Carcinoma. 38
28058101 2016
24
Mammary Analogue Secretory Carcinoma (MASC) of the salivary gland: A new tumor entity. 38
27131022 2016
25
Preservation of Facial Nerve With Adjuvant Radiotherapy for Recurrent Mammary Analogue Secretory Carcinoma of Parotid Gland. 38
27192652 2016
26
Secretory Breast Carcinoma: A Histopathologic and Genomic Spectrum Characterized by a Joint Specific ETV6-NTRK3 Gene Fusion. 38
26291510 2015
27
Secretory breast carcinoma in a 6-year-old girl: mastectomy with sentinel lymph node dissection. 38
25994562 2015
28
A rare case of secretory breast carcinoma in a male adult with axillary lymph node metastasis. 38
26045861 2015
29
Secretory breast carcinoma in a 41-year-old man with long-term follow-up: a special report. 38
26075445 2015
30
Secretory breast carcinoma in a 12-year-old girl: A case report. 38
25202382 2014
31
Secretory breast carcinoma: A report of three cases and a review of the literature. 38
25009650 2014
32
ETV6-NTRK3 as a therapeutic target of small molecule inhibitor PKC412. 38
23131561 2012
33
ETV6 disruption does not predict indolent clinical behavior in secretory breast carcinoma. 38
23078524 2012
34
Case report and review of the literature: secretory breast cancer in a 13-year-old boy--10 years of follow up. 38
22083230 2012
35
Secretory breast carcinoma: unique, triple-negative carcinoma with a favorable prognosis and characteristic molecular expression. 38
22129193 2011
36
Long-term recurrence of secretory breast carcinoma with metastatic sentinel lymph nodes. 38
20838802 2011
37
Characterization of a newly identified ETV6-NTRK3 fusion transcript in acute myeloid leukemia. 38
21401966 2011
38
ETV6-NTRK3-mediated breast epithelial cell transformation is blocked by targeting the IGF1R signaling pathway. 38
21148487 2011
39
Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. 38
20410810 2010
40
Secretory breast carcinoma in a 63-year-old man. 38
19292777 2009
41
Secretory breast carcinomas with ETV6-NTRK3 fusion gene belong to the basal-like carcinoma spectrum. 38
19011601 2009
42
ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. 38
18068631 2007
43
A rare case of secretory breast carcinoma in an elderly woman: correlation of aspiration cytology and histology. 38
18306591 2007
44
Secretory breast carcinoma with metastatic sentinel lymph node. 38
17150092 2006
45
Painless breast lump in an elderly woman. Secretory breast carcinoma in an elderly woman. 38
16831040 2006
46
Unlocking pathology archives for molecular genetic studies: a reliable method to generate probes for chromogenic and fluorescent in situ hybridization. 38
16446704 2006
47
ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages. 38
15826836 2005
48
Secretory carcinoma of the breast containing the ETV6-NTRK3 fusion gene in a male: case report and review of the literature. 38
15963235 2005
49
ETV6-NTRK3 gene fusion in a secretory carcinoma of the breast of a male-to-female transsexual. 38
15695086 2005
50
[Secretory breast carcinoma in a man. A case report with rapid evolution unfavorable]. 38
15738869 2004
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Variations for Breast Secretory Carcinoma

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Cosmic variations for Breast Secretory Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM44821 TP53 breast,NS,carcinoma,secretory c.412G>A p.A138T 17:7675200-7675200 36
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Expression for Breast Secretory Carcinoma

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Search GEO for disease gene expression data for Breast Secretory Carcinoma.
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Pathways for Breast Secretory Carcinoma

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Pathways related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytoskeletal Signaling 4
12.11 MUC1 KRT8 KRT7 KRT5
2
MAPK Signaling: Mitogen Stimulation Pathway 65
Show member pathways
 11.74 NTRK3 FGFR1 ERBB2 CDK4
3
Signaling by ERBB4 66
Show member pathways
 11.61 STAT5A PGR ERBB2
4
Cytoskeleton remodeling Neurofilaments 22
Show member pathways
 11.58 KRT8 KRT7 KRT5
5
AKT Signaling Pathway 67
11.41 NTRK3 FGFR1 ERBB2 CDK4
6
Central carbon metabolism in cancer 37
11.17 NTRK3 FGFR1 ERBB2
7
Alzheimers Disease Pathway 64
10.45 NTRK3 FGFR1 ERBB2
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GO Terms for Breast Secretory Carcinoma

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Cellular components related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 9.13 MUC4 MUC1 LALBA
2 keratin filament GO:0045095 8.8 KRT8 KRT7 KRT5

Biological processes related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.43 KRT8 KRT7 KRT5
2 positive regulation of phospholipase C activity GO:0010863 9.16 NTRK3 FGFR1
3 peptidyl-tyrosine phosphorylation GO:0018108 9.13 NTRK3 FGFR1 ERBB2
4 phosphatidylinositol phosphorylation GO:0046854 9.02 CISH
5 negative regulation of signal transduction GO:0009968 8.32 CISH

Molecular functions related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.13 NTRK3 FGFR1 ERBB2
2 protein tyrosine kinase activity GO:0004713 8.8 NTRK3 FGFR1 ERBB2
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Sources for Breast Secretory Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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