SBC
MCID: BRS062
MIFTS: 31

Breast Secretory Carcinoma (SBC)

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Breast Secretory Carcinoma

MalaCards integrated aliases for Breast Secretory Carcinoma:

Name: Breast Secretory Carcinoma 12 15
Secretory Breast Carcinoma 52 43 71
Juvenile Secretory Carcinoma of Breast 12
Secretory Carcinoma of the Breast 52
Juvenile Carcinoma of the Breast 12
Juvenile Breast Carcinoma 12
Sbc 52

Classifications:



External Ids:

Disease Ontology 12 DOID:4922
MeSH 43 C537535
NCIt 49 C4189
SNOMED-CT 67 41919003
UMLS 71 C0334371

Summaries for Breast Secretory Carcinoma

NIH Rare Diseases : 52 Secretory breast carcinoma (SBC) is a very rare, slow-growing type of breast cancer . It was originally referred to as "juvenile breast carcinoma" because it was first recognized in children and adolescents. However, many cases reported in the last several decades have occurred in adults of all ages. SBC may occur in males or females but like other types of breast cancer, it is much more common in females. Signs and symptoms of SBC most commonly include a painless, firm mass in the breast, which may move when palpated. Some people with SBC also have nipple discharge. There is currently no consensus regarding treatment for SBC, and treatment options may depend on the person's age and the size of the tumor . Options may include surgery to remove the tumor or breast (mastectomy), surgery to also remove nearby lymph nodes , radiotherapy, and chemotherapy . SBC may recur in some cases, but when this happens, it is often in the same area of the breast and after a long period of time (called a late local recurrence). SBC is usually associated with an excellent prognosis (prolonged survival), even when it spreads (metastasizes) to the lymph nodes. The risk for SBC to spread to other parts of the body is thought to be extremely low.

MalaCards based summary : Breast Secretory Carcinoma, also known as secretory breast carcinoma, is related to congenital mesoblastic nephroma and pregnancy adenoma, and has symptoms including pain An important gene associated with Breast Secretory Carcinoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways is Immune response_Oncostatin M signaling via JAK-Stat in human cells. Affiliated tissues include breast, lymph node and salivary gland.

Disease Ontology : 12 A breast adenocarcinoma that has material basis in cells with abundant granular or clear vacuolated cytoplasm.

Related Diseases for Breast Secretory Carcinoma

Diseases related to Breast Secretory Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 congenital mesoblastic nephroma 30.2 NTRK3 ETV6
2 pregnancy adenoma 30.2 NTRK3 ETV6
3 congenital fibrosarcoma 30.1 SERPINA3 NTRK3 ETV6
4 acinar cell carcinoma 29.8 SERPINA3 NTRK3 MAML2 ETV6
5 salivary gland carcinoma 29.1 SERPINA3 NTRK3 NFIB MAML2 ETV6
6 breast cystic hypersecretory carcinoma 11.4
7 neural tube defects 11.4
8 cellular congenital mesoblastic nephroma 10.3 NTRK3 ETV6
9 adult fibrosarcoma 10.3 NTRK3 ETV6
10 rare tumor 10.3
11 cerebellar angioblastoma 10.3 NTRK3 ETV6
12 papillary cystadenocarcinoma 10.2 SERPINA3 MAML2
13 adult mesoblastic nephroma 10.2 NTRK3 ETV6
14 lung adenoid cystic carcinoma 10.2 NFIB MAML2
15 polymorphous low-grade adenocarcinoma 10.2 NTRK3 NFIB
16 kidney clear cell sarcoma 10.2 NTRK3 ETV6
17 spindle cell sarcoma 10.2 SERPINA3 NTRK3
18 bladder cancer 10.2
19 myocardial infarction 10.2
20 angina pectoris 10.2
21 chagas disease 10.2
22 coronary restenosis 10.2
23 intermediate coronary syndrome 10.2
24 infantile myofibromatosis 10.2 NTRK3 ETV6
25 pleomorphic adenoma carcinoma 10.2 NFIB MAML2
26 mesenchymal cell neoplasm 10.1 SERPINA3 NTRK3
27 pediatric fibrosarcoma 10.1 SERPINA3 NTRK3 ETV6
28 papilloma 10.0
29 apocrine sweat gland neoplasm 10.0 SERPINA3 PIP
30 adenoid cystic carcinoma 10.0 SERPINA3 NTRK3 NFIB
31 apocrine adenocarcinoma 10.0 SERPINA3 PIP
32 clear cell hidradenoma 10.0 PIP MAML2
33 fibrosarcoma 10.0
34 rare malignant breast tumor 10.0
35 myelodysplastic/myeloproliferative neoplasm 10.0 STAT5A ETV6
36 hidradenoma 10.0 PIP MAML2
37 sweat gland disease 10.0 SERPINA3 PIP
38 sweat gland neoplasm 10.0 PIP MAML2
39 cutaneous adenocystic carcinoma 10.0 PIP NFIB
40 thoracic benign neoplasm 9.9 SERPINA3 PIP
41 breast benign neoplasm 9.9 SERPINA3 PIP
42 breast cyst 9.9 SERPINA3 PIP
43 retinoblastoma 9.9
44 squamous cell papilloma 9.9
45 familial retinoblastoma 9.9
46 microglandular adenosis 9.9
47 48,xyyy 9.9
48 posttransplant acute limbic encephalitis 9.9
49 rare breast tumor 9.9
50 monosomy 22 9.9

Graphical network of the top 20 diseases related to Breast Secretory Carcinoma:



Diseases related to Breast Secretory Carcinoma

Symptoms & Phenotypes for Breast Secretory Carcinoma

UMLS symptoms related to Breast Secretory Carcinoma:


pain

Drugs & Therapeutics for Breast Secretory Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Secretory Carcinoma

Cochrane evidence based reviews: secretory breast carcinoma

Genetic Tests for Breast Secretory Carcinoma

Anatomical Context for Breast Secretory Carcinoma

MalaCards organs/tissues related to Breast Secretory Carcinoma:

40
Breast, Lymph Node, Salivary Gland, Thyroid, Lung, Testes, Liver

Publications for Breast Secretory Carcinoma

Articles related to Breast Secretory Carcinoma:

(show top 50) (show all 71)
# Title Authors PMID Year
1
Rare breast cancer: 246 invasive secretory carcinomas from the National Cancer Data Base. 61 52
27040042 2016
2
Secretory breast carcinoma: a clinicopathological and immunophenotypic study of 15 cases with a review of the literature. 61 52
22157932 2012
3
A case of secretory breast cancer in a 6 year-old girl: is it possible to make a correct preoperative diagnosis? 61
32002789 2020
4
Secretory Carcinoma of the Thyroid Gland: Report of a Highly Aggressive Case Clinically Mimicking Undifferentiated Carcinoma and Review of the Literature. 61
30564997 2019
5
Is secretory breast carcinoma underdiagnosed? In the era of targeted therapy should there be a low threshold to screen for NTRK immunohistochemistry in triple negative breast cancers? 61
31470990 2019
6
Pure secretory carcinoma in situ: a case report and literature review. 61
31443715 2019
7
Pan-Trk immunohistochemistry reliably identifies ETV6-NTRK3 fusion in secretory carcinoma of the salivary gland. 61
31423558 2019
8
[Clinicopathologic features of secretory breast carcinoma]. 61
31434456 2019
9
Neurotrophic tropomyosin or t´╗┐yrosine receptor kinase (NTRK) genes. 61
30636697 2019
10
Clinicopathologic and molecular characteristics of 44 patients with pure secretory breast carcinoma. 61
31119054 2019
11
Secretory Carcinoma of the Parotid: Making the Correct Diagnosis of a Rare Salivary Gland Carcinoma When Molecular Biology Testing Is Not Available. 61
31007960 2019
12
Molecular characterization of cancers with NTRK gene fusions. 61
30171197 2019
13
Secretory carcinoma of the breast: A case report. 61
30852371 2019
14
How I treat NTRK gene fusion-positive cancers. 61
31803506 2019
15
Secretory breast carcinoma in an 8-year-old girl: A case report and literature review. 61
30251458 2018
16
Secretory Carcinoma of the Breast in a 20-year-old Male: Case Report and Review of Literature. 61
30283227 2018
17
Novel identification of STAT1 as a crucial mediator of ETV6-NTRK3-induced tumorigenesis. 61
29391602 2018
18
Primary cutaneous secretory carcinoma: A previously overlooked low-grade sweat gland carcinoma. 61
29205457 2018
19
Recurrent EML4-NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy. 61
29099503 2018
20
Mammary Analogue Secretory Carcinoma of Minor Salivary Glands: A Rare Case Series and Review of the Literature. 61
29531003 2018
21
Secretory breast carcinoma with a papillary-predominant pattern: an unusual morphological variant. 61
28383794 2017
22
Genomic profiling of breast secretory carcinomas reveals distinct genetics from other breast cancers and similarity to mammary analog secretory carcinomas. 61
28548128 2017
23
Cytologic findings of mammary analogue secretory carcinoma arising in the thyroid. 61
28251831 2017
24
Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Salivary Gland. 61
28247227 2017
25
[Secretory breast carcinoma with liver metastatic: report of a case]. 61
28173678 2017
26
Successful Targeted Therapy of Refractory Pediatric ETV6-NTRK3 Fusion-Positive Secretory Breast Carcinoma. 61
29623306 2017
27
Secretory Carcinoma in a 79- Year-Old Woman: An Exceptionally Rare Type of Breast Carcinoma. 61
28058101 2016
28
Mammary Analogue Secretory Carcinoma (MASC) of the salivary gland: A new tumor entity. 61
27131022 2016
29
Preservation of Facial Nerve With Adjuvant Radiotherapy for Recurrent Mammary Analogue Secretory Carcinoma of Parotid Gland. 61
27192652 2016
30
Secretory Breast Carcinoma: A Histopathologic and Genomic Spectrum Characterized by a Joint Specific ETV6-NTRK3 Gene Fusion. 61
26291510 2015
31
Secretory breast carcinoma in a 6-year-old girl: mastectomy with sentinel lymph node dissection. 61
25994562 2015
32
A rare case of secretory breast carcinoma in a male adult with axillary lymph node metastasis. 61
26045861 2015
33
Secretory breast carcinoma in a 41-year-old man with long-term follow-up: a special report. 61
26075445 2015
34
Secretory breast carcinoma in a 12-year-old girl: A case report. 61
25202382 2014
35
Secretory breast carcinoma: A report of three cases and a review of the literature. 61
25009650 2014
36
ETV6-NTRK3 as a therapeutic target of small molecule inhibitor PKC412. 61
23131561 2012
37
ETV6 disruption does not predict indolent clinical behavior in secretory breast carcinoma. 61
23078524 2012
38
Case report and review of the literature: secretory breast cancer in a 13-year-old boy--10 years of follow up. 61
22083230 2012
39
Secretory breast carcinoma: unique, triple-negative carcinoma with a favorable prognosis and characteristic molecular expression. 61
22129193 2011
40
Long-term recurrence of secretory breast carcinoma with metastatic sentinel lymph nodes. 61
20838802 2011
41
Characterization of a newly identified ETV6-NTRK3 fusion transcript in acute myeloid leukemia. 61
21401966 2011
42
ETV6-NTRK3-mediated breast epithelial cell transformation is blocked by targeting the IGF1R signaling pathway. 61
21148487 2011
43
Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. 61
20410810 2010
44
Secretory breast carcinoma in a 63-year-old man. 61
19292777 2009
45
Secretory breast carcinomas with ETV6-NTRK3 fusion gene belong to the basal-like carcinoma spectrum. 61
19011601 2009
46
ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. 61
18068631 2007
47
A rare case of secretory breast carcinoma in an elderly woman: correlation of aspiration cytology and histology. 61
18306591 2007
48
Secretory breast carcinoma with metastatic sentinel lymph node. 61
17150092 2006
49
Painless breast lump in an elderly woman. Secretory breast carcinoma in an elderly woman. 61
16831040 2006
50
Unlocking pathology archives for molecular genetic studies: a reliable method to generate probes for chromogenic and fluorescent in situ hybridization. 61
16446704 2006

Variations for Breast Secretory Carcinoma

Cosmic variations for Breast Secretory Carcinoma:

9 (show all 19)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM87990610 TP53 breast,NS,carcinoma,secretory c.412G>A p.A138T 17:7675200-7675200 27
2 COSM144732052 breast,NS,carcinoma,secretory c.295G>A p.A99T 17:7675200-7675200 27
3 COSM106128638 breast,NS,carcinoma,secretory c.412G>A p.A138T 17:7675200-7675200 27
4 COSM121958859 breast,NS,carcinoma,secretory c.16G>A p.A6T 17:7675200-7675200 27
5 COSM122817277 breast,NS,carcinoma,secretory c.16G>A p.A6T 17:7675200-7675200 27
6 COSM144376276 breast,NS,carcinoma,secretory c.295G>A p.A99T 17:7675200-7675200 27
7 COSM142638851 breast,NS,carcinoma,secretory c.295G>A p.A99T 17:7675200-7675200 27
8 COSM93261665 breast,NS,carcinoma,secretory c.412G>A p.A138T 17:7675200-7675200 27
9 COSM111840743 breast,NS,carcinoma,secretory c.412G>A p.A138T 17:7675200-7675200 27
10 COSM143224457 breast,NS,carcinoma,secretory c.-66G>A p.? 17:7675200-7675200 27
11 COSM144017112 breast,NS,carcinoma,secretory c.-66G>A p.? 17:7675200-7675200 27
12 COSM144152557 breast,NS,carcinoma,secretory c.-66G>A p.? 17:7675200-7675200 27
13 COSM105709638 breast,NS,carcinoma,secretory c.412G>A p.A138T 17:7675200-7675200 27
14 COSM142903561 breast,NS,carcinoma,secretory c.412G>A p.A138T 17:7675200-7675200 27
15 COSM145087547 breast,NS,carcinoma,secretory c.295G>A p.A99T 17:7675200-7675200 27
16 COSM122343382 breast,NS,carcinoma,secretory c.16G>A p.A6T 17:7675200-7675200 27
17 COSM143444930 breast,NS,carcinoma,secretory c.295G>A p.A99T 17:7675200-7675200 27
18 COSM144083566 breast,NS,carcinoma,secretory c.379G>A p.A127T 17:7675200-7675200 27
19 COSM112331177 breast,NS,carcinoma,secretory c.412G>A p.A138T 17:7675200-7675200 27

Expression for Breast Secretory Carcinoma

Search GEO for disease gene expression data for Breast Secretory Carcinoma.

Pathways for Breast Secretory Carcinoma

Pathways related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.9 STAT5A SERPINA3

GO Terms for Breast Secretory Carcinoma

Biological processes related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 maintenance of gastrointestinal epithelium GO:0030277 8.62 SERPINA3 MUC4

Sources for Breast Secretory Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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