MCID: BRS062
MIFTS: 42

Breast Secretory Carcinoma

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Breast Secretory Carcinoma

MalaCards integrated aliases for Breast Secretory Carcinoma:

Name: Breast Secretory Carcinoma 12 15
Secretory Breast Carcinoma 54 45 74
Juvenile Secretory Carcinoma of Breast 12
Secretory Carcinoma of the Breast 54
Juvenile Carcinoma of the Breast 12
Juvenile Breast Carcinoma 12
Sbc 54

Classifications:



External Ids:

Disease Ontology 12 DOID:4922
MeSH 45 C537535
NCIt 51 C4189
SNOMED-CT 69 41919003
UMLS 74 C0334371

Summaries for Breast Secretory Carcinoma

NIH Rare Diseases : 54 Secretory breast carcinoma (SBC) is a very rare, slow-growing type of breast cancer. It was originally referred to as "juvenile breast carcinoma" because it was first recognized in children and adolescents. However, many cases reported in the last several decades have occurred in adults of all ages. SBC may occur in males or females but like other types of breast cancer, it is much more common in females. Signs and symptoms of SBC most commonly include a painless, firm mass in the breast, which may move when palpated. Some people with SBC also have nipple discharge. There is currently no consensus regarding treatment for SBC, and treatment options may depend on the person's age and the size of the tumor. Options may include surgery to remove the tumor or breast (mastectomy), surgery to also remove nearby lymph nodes, radiotherapy, and chemotherapy. SBC may recur in some cases, but when this happens, it is often in the same area of the breast and after a long period of time (called a late local recurrence). SBC is usually associated with an excellent prognosis (prolonged survival), even when it spreads (metastasizes) to the lymph nodes. The risk for SBC to spread to other parts of the body is thought to be extremely low.

MalaCards based summary : Breast Secretory Carcinoma, also known as secretory breast carcinoma, is related to breast cystic hypersecretory carcinoma and papilloma, and has symptoms including pain An important gene associated with Breast Secretory Carcinoma is NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3), and among its related pathways/superpathways are Cytoskeletal Signaling and MAPK Signaling: Mitogen Stimulation Pathway. The drug 9-Fluoro-15-methyl-2,11,16,20,21,24-hexaazapentacyclo(16.5.2.02,6.07,12.021,2... has been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A breast adenocarcinoma that has material basis in cells with abundant granular or clear vacuolated cytoplasm.

Related Diseases for Breast Secretory Carcinoma

Diseases related to Breast Secretory Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 breast cystic hypersecretory carcinoma 31.8 ERBB2 KRT5 LALBA TG
2 papilloma 30.1 KRT5 KRT7 KRT8
3 breast cancer 29.2 CDK4 ERBB2 FGFR1 KRT5 KRT8 MUC1
4 neural tube defects 11.3
5 adult mesoblastic nephroma 10.5 ETV6 NTRK3
6 primary hypereosinophilic syndrome 10.4 ETV6 FGFR1
7 pediatric fibrosarcoma 10.4 ETV6 NTRK3
8 breast osteosarcoma 10.3 ERBB2 KRT8
9 scirrhous adenocarcinoma 10.3 ERBB2 PGR
10 breast apocrine carcinoma 10.3 ERBB2 PGR
11 glassy cell carcinoma of the cervix 10.3 ERBB2 PGR
12 inverted transitional papilloma 10.3 KRT5 KRT7
13 balloon cell malignant melanoma 10.3 KRT5 KRT7
14 benign breast adenomyoepithelioma 10.3 KRT5 KRT7
15 ceruminoma 10.3 KRT5 KRT7
16 intracystic papillary adenoma 10.3 ERBB2 PGR
17 malignant spiradenoma 10.3 KRT5 KRT7
18 benign mesothelioma 10.3 KRT5 KRT7
19 progesterone-receptor negative breast cancer 10.3 ERBB2 PGR
20 adult fibrosarcoma 10.3 ETV6 NTRK3
21 proliferating trichilemmal cyst 10.3 KRT7 KRT8
22 endolymphatic sac tumor 10.3 KRT7 KRT8
23 breast medullary carcinoma 10.3 ERBB2 PGR
24 sensory organ benign neoplasm 10.3 KRT5 KRT7
25 large cell acanthoma 10.3 KRT5 KRT7
26 progesterone-receptor positive breast cancer 10.3 ERBB2 PGR
27 breast squamous cell carcinoma 10.3 ERBB2 KRT5
28 eccrine papillary adenocarcinoma 10.3 KRT7 PGR
29 adenoid squamous cell carcinoma 10.2 KRT7 KRT8
30 lymphoepithelioma-like thymic carcinoma 10.2 KRT5 TG
31 cervical clear cell adenocarcinoma 10.2 KRT5 KRT8 PGR
32 oncocytic breast carcinoma 10.2 KRT7 PGR
33 differentiated thyroid carcinoma 10.2 ETV6 NTRK3 TG
34 nasal cavity cancer 10.2 KRT7 KRT8
35 cribriform carcinoma 10.2 KRT7 PGR
36 benign metastasizing leiomyoma 10.2 KRT7 PGR
37 ovarian germ cell teratoma 10.2 KRT7 TG
38 breast metaplastic carcinoma 10.2 ERBB2 KRT5 PGR
39 ovarian germ cell cancer 10.2 KRT7 TG
40 uterine body mixed cancer 10.2 ERBB2 PGR
41 breast benign neoplasm 10.2 ERBB2 KRT5 PGR
42 vulval paget's disease 10.2 ERBB2 KRT7
43 thoracic benign neoplasm 10.2 ERBB2 KRT5 PGR
44 chronic ethmoiditis 10.2 MUC1 MUC4
45 breast adenoid cystic carcinoma 10.2 ERBB2 PGR
46 pancreatic serous cystadenoma 10.2 KRT7 PGR
47 pre-malignant neoplasm 10.2 ERBB2 KRT5 PGR
48 malignant mesenchymoma 10.2 CDK4 ETV6 NTRK3
49 in situ carcinoma 10.2 ERBB2 KRT5 PGR
50 chagas disease 10.2

Graphical network of the top 20 diseases related to Breast Secretory Carcinoma:



Diseases related to Breast Secretory Carcinoma

Symptoms & Phenotypes for Breast Secretory Carcinoma

UMLS symptoms related to Breast Secretory Carcinoma:


pain

GenomeRNAi Phenotypes related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

27 (show all 28)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.89 SOX10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.89 CDK4 SOX10
3 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.89 CDK4 STAT5A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.89 NTRK3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.89 NTRK3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.89 STAT5A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.89 NTRK3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-158 9.89 STAT5A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.89 ERBB2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.89 ERBB2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.89 ERBB2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.89 SOX10
13 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.89 STAT5A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.89 STAT5A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.89 ERBB2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.89 CDK4
17 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.89 NTRK3
18 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.89 ERBB2 SOX10
19 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.89 NTRK3
20 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.89 CDK4 NTRK3 STAT5A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.89 CDK4
22 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.89 SOX10
23 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.89 ERBB2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.89 SOX10
25 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.89 SOX10
26 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.89 STAT5A
27 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.89 SOX10
28 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.89 CDK4 ERBB2 NTRK3 SOX10 STAT5A

MGI Mouse Phenotypes related to Breast Secretory Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.1 CDK4 CISH ERBB2 ETV6 FGFR1 LALBA
2 growth/size/body region MP:0005378 10.07 CDK4 ERBB2 ETV6 FGFR1 KRT5 KRT8
3 digestive/alimentary MP:0005381 10.06 CDK4 ERBB2 ETV6 FGFR1 KRT5 KRT8
4 homeostasis/metabolism MP:0005376 10.06 CDK4 CISH ERBB2 ETV6 FGFR1 KRT7
5 embryo MP:0005380 9.98 CDK4 ERBB2 ETV6 FGFR1 KRT8 PGR
6 integument MP:0010771 9.91 CDK4 ERBB2 ETV6 FGFR1 KRT5 LALBA
7 limbs/digits/tail MP:0005371 9.63 ERBB2 FGFR1 KRT5 PGR SOX10 TG
8 no phenotypic analysis MP:0003012 9.43 ETV6 FGFR1 KRT5 NTRK3 PGR SOX10
9 normal MP:0002873 9.28 CDK4 ERBB2 ETV6 FGFR1 LALBA NTRK3

Drugs & Therapeutics for Breast Secretory Carcinoma

Drugs for Breast Secretory Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 9-Fluoro-15-methyl-2,11,16,20,21,24-hexaazapentacyclo(16.5.2.02,6.07,12.021,2... Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 1/2 Study of LOXO-195 in Patients With Previously Treated NTRK Fusion Cancers Recruiting NCT03215511 Phase 1, Phase 2 LOXO-195

Search NIH Clinical Center for Breast Secretory Carcinoma

Cochrane evidence based reviews: secretory breast carcinoma

Genetic Tests for Breast Secretory Carcinoma

Anatomical Context for Breast Secretory Carcinoma

MalaCards organs/tissues related to Breast Secretory Carcinoma:

42
Breast, Lymph Node, Thyroid, Bone, Spinal Cord, Bone Marrow, Thymus

Publications for Breast Secretory Carcinoma

Articles related to Breast Secretory Carcinoma:

(show all 29)
# Title Authors Year
1
Secretory breast carcinoma in an 8-year-old girl: A case report and literature review. ( 30251458 )
2018
2
Secretory breast carcinoma with a papillary-predominant pattern: an unusual morphological variant. ( 28383794 )
2017
3
Successful Targeted Therapy of Refractory Pediatric ETV6-NTRK3 Fusion-Positive Secretory Breast Carcinoma. ( 29623306 )
2017
4
Secretory Breast Carcinoma: A Histopathologic and Genomic Spectrum Characterized by a Joint Specific ETV6-NTRK3 Gene Fusion. ( 26291510 )
2015
5
Secretory breast carcinoma in a 6-year-old girl: mastectomy with sentinel lymph node dissection. ( 25994562 )
2015
6
A rare case of secretory breast carcinoma in a male adult with axillary lymph node metastasis. ( 26045861 )
2015
7
Secretory breast carcinoma in a 41-year-old man with long-term follow-up: a special report. ( 26075445 )
2015
8
Secretory breast carcinoma in a 12-year-old girl: A case report. ( 25202382 )
2014
9
Secretory breast carcinoma: A report of three cases and a review of the literature. ( 25009650 )
2014
10
ETV6 disruption does not predict indolent clinical behavior in secretory breast carcinoma. ( 23078524 )
2012
11
Secretory breast carcinoma: a clinicopathological and immunophenotypic study of 15 cases with a review of the literature. ( 22157932 )
2012
12
Secretory breast carcinoma: unique, triple-negative carcinoma with a favorable prognosis and characteristic molecular expression. ( 22129193 )
2011
13
Long-term recurrence of secretory breast carcinoma with metastatic sentinel lymph nodes. ( 20838802 )
2011
14
Secretory breast carcinoma in a 63-year-old man. ( 19292777 )
2009
15
A rare case of secretory breast carcinoma in an elderly woman: correlation of aspiration cytology and histology. ( 18306591 )
2007
16
Secretory breast carcinoma with metastatic sentinel lymph node. ( 17150092 )
2006
17
Painless breast lump in an elderly woman. Secretory breast carcinoma in an elderly woman. ( 16831040 )
2006
18
A fluorescence in situ hybridization study of ETV6-NTRK3 fusion gene in secretory breast carcinoma. ( 15101049 )
2004
19
Secretory breast carcinoma--case report and review of the medical literature. ( 15325674 )
2004
20
Secretory breast carcinoma with extensive intraductal component: case report. ( 15764584 )
2004
21
Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. ( 12450792 )
2002
22
Secretory breast carcinoma in a 9-year-old boy. ( 10711481 )
2000
23
Secretory breast carcinoma in a boy. ( 10188866 )
1999
24
Fine needle aspiration of secretory breast carcinoma resembling lactational changes. A case report. ( 9684599 )
1998
25
Secretory breast carcinoma in a 66 year old man. ( 9797736 )
1998
26
Secretory breast carcinoma in a man diagnosed by fine needle aspiration biopsy. A case report. ( 8191840 )
1994
27
Multicentric adult secretory breast carcinoma: DNA flow cytometric findings, prognostic features, and review of the world literature. ( 2200927 )
1990
28
Secretory breast carcinoma in a man. ( 3341512 )
1988
29
Tubular carcinoma: a variant of secretory breast carcinoma. ( 488923 )
1979

Variations for Breast Secretory Carcinoma

Cosmic variations for Breast Secretory Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM44821 TP53 breast,NS,carcinoma,secretory c.412G>A p.A138T 17:7675200-7675200 0

Expression for Breast Secretory Carcinoma

Search GEO for disease gene expression data for Breast Secretory Carcinoma.

Pathways for Breast Secretory Carcinoma

GO Terms for Breast Secretory Carcinoma

Cellular components related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 9.13 LALBA MUC1 MUC4
2 keratin filament GO:0045095 8.8 KRT5 KRT7 KRT8

Biological processes related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 9.54 ERBB2 FGFR1 NTRK3
2 cornification GO:0070268 9.43 KRT5 KRT7 KRT8
3 positive regulation of phospholipase C activity GO:0010863 9.16 FGFR1 NTRK3
4 peptidyl-tyrosine phosphorylation GO:0018108 9.13 ERBB2 FGFR1 NTRK3
5 phosphatidylinositol phosphorylation GO:0046854 9.02 CISH
6 negative regulation of signal transduction GO:0009968 8.32 CISH

Molecular functions related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.13 ERBB2 FGFR1 NTRK3
2 protein tyrosine kinase activity GO:0004713 8.8 ERBB2 FGFR1 NTRK3

Sources for Breast Secretory Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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