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SBC
MCID: BRS062
MIFTS: 31

Breast Secretory Carcinoma (SBC)

Categories: Cancer diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Breast Secretory Carcinoma

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MalaCards integrated aliases for Breast Secretory Carcinoma:

Name: Breast Secretory Carcinoma 12 15
Secretory Breast Carcinoma 20 44 71
Juvenile Secretory Carcinoma of Breast 12
Secretory Carcinoma of the Breast 20
Juvenile Carcinoma of the Breast 12
Juvenile Breast Carcinoma 12
Sbc 20

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
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Disease Ontology 12 DOID:4922
MeSH 44 C537535
NCIt 50 C4189
SNOMED-CT 67 41919003
UMLS 71 C0334371
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Summaries for Breast Secretory Carcinoma

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GARD : 20 Secretory breast carcinoma (SBC) is a very rare, slow-growing type of breast cancer. It was originally referred to as "juvenile breast carcinoma" because it was first recognized in children and adolescents. However, many cases reported in the last several decades have occurred in adults of all ages. SBC may occur in males or females but like other types of breast cancer, it is much more common in females. Signs and symptoms of SBC most commonly include a painless, firm mass in the breast, which may move when palpated. Some people with SBC also have nipple discharge. There is currently no consensus regarding treatment for SBC, and treatment options may depend on the person's age and the size of the tumor. Options may include surgery to remove the tumor or breast (mastectomy), surgery to also remove nearby lymph nodes, radiotherapy, and chemotherapy. SBC may recur in some cases, but when this happens, it is often in the same area of the breast and after a long period of time (called a late local recurrence). SBC is usually associated with an excellent prognosis (prolonged survival), even when it spreads (metastasizes) to the lymph nodes. The risk for SBC to spread to other parts of the body is thought to be extremely low.

MalaCards based summary : Breast Secretory Carcinoma, also known as secretory breast carcinoma, is related to breast cystic hypersecretory carcinoma and acinar cell carcinoma, and has symptoms including pain An important gene associated with Breast Secretory Carcinoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways is Immune response_Oncostatin M signaling via JAK-Stat in human cells. Affiliated tissues include breast, salivary gland and lymph node.

Disease Ontology : 12 A breast adenocarcinoma that has material basis in cells with abundant granular or clear vacuolated cytoplasm.

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Related Diseases for Breast Secretory Carcinoma

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Diseases related to Breast Secretory Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 breast cystic hypersecretory carcinoma 32.0 LALBA KRT5
2 acinar cell carcinoma 30.4 SERPINA3 NTRK3 ETV6
3 congenital mesoblastic nephroma 30.3 NTRK3 ETV6
4 nephroma 30.2 NTRK3 ETV6
5 adult fibrosarcoma 30.2 NTRK3 ETV6
6 congenital fibrosarcoma 30.0 SERPINA3 NTRK3 ETV6
7 pregnancy adenoma 29.8 NTRK3 LALBA KRT5
8 neural tube defects 11.1
9 rare tumor 10.3
10 cellular congenital mesoblastic nephroma 10.2 NTRK3 ETV6
11 gastric squamous cell carcinoma 10.2 SERPINA3 KRT5
12 sarcomatoid squamous cell skin carcinoma 10.2 SERPINA3 KRT5
13 breast cyst 10.2 SERPINA3 PIP
14 cerebellar angioblastoma 10.2 NTRK3 ETV6
15 breast malignant phyllodes tumor 10.2 SERPINA3 KRT5
16 syringocystadenoma papilliferum 10.2 SERPINA3 PIP
17 ceruminoma 10.2 PIP KRT5
18 kidney cortex disease 10.2 NTRK3 ETV6
19 malignant acrospiroma 10.2 PIP KRT5
20 heart cancer 10.2 SERPINA3 KRT5
21 ceruminous adenocarcinoma 10.2 PIP KRT5
22 cutaneous mucoepidermoid carcinoma 10.2 PIP KRT5
23 eccrine adenocarcinoma 10.2 PIP KRT5
24 papillary cystadenocarcinoma 10.2 SERPINA3 PIP
25 vulvar apocrine adenocarcinoma 10.2 PIP KRT5
26 malignant syringoma 10.2 PIP KRT5
27 breast mucinous carcinoma 10.2 PIP KRT5
28 bladder sarcoma 10.2 SERPINA3 KRT5
29 clear cell hidradenoma 10.2 PIP KRT5
30 hidradenoma 10.2 PIP KRT5
31 kidney benign neoplasm 10.2 NTRK3 ETV6
32 papilloma 10.2
33 eccrine sweat gland cancer 10.2 PIP KRT5
34 sweat gland cancer 10.2 PIP KRT5
35 eccrine papillary adenocarcinoma 10.2 PIP KRT5
36 eccrine acrospiroma 10.2 PIP KRT5
37 eccrine sweat gland neoplasm 10.2 PIP KRT5
38 apocrine sweat gland neoplasm 10.1 PIP KRT5
39 malignant spiradenoma 10.1 PIP KRT5
40 cribriform carcinoma 10.1 PIP KRT5
41 mesenchymal cell neoplasm 10.1 SERPINA3 NTRK3
42 pleomorphic adenoma carcinoma 10.1 NTRK3 NFIB
43 bartholin's gland adenocarcinoma 10.1 PIP KRT5
44 mixed cell type cancer 10.1 SERPINA3 KRT5
45 eccrine papillary adenoma 10.1 PIP KRT5
46 infantile myofibromatosis 10.1 NTRK3 ETV6
47 borst-jadassohn intraepidermal carcinoma 10.1 PIP KRT5
48 polymorphous low-grade adenocarcinoma 10.1 NTRK3 NFIB
49 paget disease, extramammary 10.1 PIP KRT5
50 glycogen-rich clear cell breast carcinoma 10.1 PIP LALBA

Graphical network of the top 20 diseases related to Breast Secretory Carcinoma:



Diseases related to Breast Secretory Carcinoma
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Symptoms & Phenotypes for Breast Secretory Carcinoma

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UMLS symptoms related to Breast Secretory Carcinoma:


pain
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Drugs & Therapeutics for Breast Secretory Carcinoma

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Search Clinical Trials , NIH Clinical Center for Breast Secretory Carcinoma

Cochrane evidence based reviews: secretory breast carcinoma

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Genetic Tests for Breast Secretory Carcinoma

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Anatomical Context for Breast Secretory Carcinoma

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MalaCards organs/tissues related to Breast Secretory Carcinoma:

40
Breast, Salivary Gland, Lymph Node, Thyroid, Myeloid
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Publications for Breast Secretory Carcinoma

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Articles related to Breast Secretory Carcinoma:

(show top 50) (show all 75)
# Title Authors PMID Year
1
Rare breast cancer: 246 invasive secretory carcinomas from the National Cancer Data Base. 61 20
27040042 2016
2
Secretory breast carcinoma: a clinicopathological and immunophenotypic study of 15 cases with a review of the literature. 61 20
22157932 2012
3
Dedifferentiated secretory breast carcinoma with fibrosarcomatous features harboring an ETV6-NTRK3 fusion in both components. 61
33342011 2020
4
MR imaging findings of a rare pediatric parotid tumor: Mammary analogue secretory carcinoma. 61
32642018 2020
5
A case of secretory breast cancer in a 6 year-old girl: is it possible to make a correct preoperative diagnosis? 61
32002789 2020
6
Pan-Trk immunohistochemistry reliably identifies ETV6-NTRK3 fusion in secretory carcinoma of the salivary gland. 61
31423558 2020
7
A systematic review and meta-analysis of neurotrophic tyrosine receptor kinase gene fusion frequencies in solid tumors. 61
33425024 2020
8
Secretory breast carcinoma in a male child: Case report and literature review. 61
32736235 2020
9
Secretory Carcinoma of the Thyroid Gland: Report of a Highly Aggressive Case Clinically Mimicking Undifferentiated Carcinoma and Review of the Literature. 61
30564997 2019
10
Is secretory breast carcinoma underdiagnosed? In the era of targeted therapy should there be a low threshold to screen for NTRK immunohistochemistry in triple negative breast cancers? 61
31470990 2019
11
[Clinicopathologic features of secretory breast carcinoma]. 61
31434456 2019
12
Pure secretory carcinoma in situ: a case report and literature review. 61
31443715 2019
13
Neurotrophic tropomyosin or tyrosine receptor kinase (NTRK) genes. 61
30636697 2019
14
Clinicopathologic and molecular characteristics of 44 patients with pure secretory breast carcinoma. 61
31119054 2019
15
Secretory Carcinoma of the Parotid: Making the Correct Diagnosis of a Rare Salivary Gland Carcinoma When Molecular Biology Testing Is Not Available. 61
31007960 2019
16
Molecular characterization of cancers with NTRK gene fusions. 61
30171197 2019
17
Secretory carcinoma of the breast: A case report. 61
30852371 2019
18
How I treat NTRK gene fusion-positive cancers. 61
31803506 2019
19
Secretory breast carcinoma in an 8-year-old girl: A case report and literature review. 61
30251458 2018
20
Secretory Carcinoma of the Breast in a 20-year-old Male: Case Report and Review of Literature. 61
30283227 2018
21
Novel identification of STAT1 as a crucial mediator of ETV6-NTRK3-induced tumorigenesis. 61
29391602 2018
22
Recurrent EML4-NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy. 61
29099503 2018
23
Primary cutaneous secretory carcinoma: A previously overlooked low-grade sweat gland carcinoma. 61
29205457 2018
24
Mammary Analogue Secretory Carcinoma of Minor Salivary Glands: A Rare Case Series and Review of the Literature. 61
29531003 2018
25
Secretory breast carcinoma with a papillary-predominant pattern: an unusual morphological variant. 61
28383794 2017
26
Genomic profiling of breast secretory carcinomas reveals distinct genetics from other breast cancers and similarity to mammary analog secretory carcinomas. 61
28548128 2017
27
Cytologic findings of mammary analogue secretory carcinoma arising in the thyroid. 61
28251831 2017
28
Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Salivary Gland. 61
28247227 2017
29
[Secretory breast carcinoma with liver metastatic: report of a case]. 61
28173678 2017
30
Successful Targeted Therapy of Refractory Pediatric ETV6-NTRK3 Fusion-Positive Secretory Breast Carcinoma. 61
29623306 2017
31
Secretory Carcinoma in a 79- Year-Old Woman: An Exceptionally Rare Type of Breast Carcinoma. 61
28058101 2016
32
Mammary Analogue Secretory Carcinoma (MASC) of the salivary gland: A new tumor entity. 61
27131022 2016
33
Preservation of Facial Nerve With Adjuvant Radiotherapy for Recurrent Mammary Analogue Secretory Carcinoma of Parotid Gland. 61
27192652 2016
34
Secretory Breast Carcinoma: A Histopathologic and Genomic Spectrum Characterized by a Joint Specific ETV6-NTRK3 Gene Fusion. 61
26291510 2015
35
Secretory breast carcinoma in a 6-year-old girl: mastectomy with sentinel lymph node dissection. 61
25994562 2015
36
A rare case of secretory breast carcinoma in a male adult with axillary lymph node metastasis. 61
26045861 2015
37
Secretory breast carcinoma in a 41-year-old man with long-term follow-up: a special report. 61
26075445 2015
38
Secretory breast carcinoma in a 12-year-old girl: A case report. 61
25202382 2014
39
Secretory breast carcinoma: A report of three cases and a review of the literature. 61
25009650 2014
40
ETV6-NTRK3 as a therapeutic target of small molecule inhibitor PKC412. 61
23131561 2012
41
ETV6 disruption does not predict indolent clinical behavior in secretory breast carcinoma. 61
23078524 2012
42
Case report and review of the literature: secretory breast cancer in a 13-year-old boy--10 years of follow up. 61
22083230 2012
43
Secretory breast carcinoma: unique, triple-negative carcinoma with a favorable prognosis and characteristic molecular expression. 61
22129193 2011
44
Long-term recurrence of secretory breast carcinoma with metastatic sentinel lymph nodes. 61
20838802 2011
45
Characterization of a newly identified ETV6-NTRK3 fusion transcript in acute myeloid leukemia. 61
21401966 2011
46
ETV6-NTRK3-mediated breast epithelial cell transformation is blocked by targeting the IGF1R signaling pathway. 61
21148487 2011
47
Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. 61
20410810 2010
48
Secretory breast carcinoma in a 63-year-old man. 61
19292777 2009
49
Secretory breast carcinomas with ETV6-NTRK3 fusion gene belong to the basal-like carcinoma spectrum. 61
19011601 2009
50
ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. 61
18068631 2007
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Variations for Breast Secretory Carcinoma

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Cosmic variations for Breast Secretory Carcinoma:

9 (show all 19)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM144732052 TP53 breast,NS,carcinoma,secretory c.295G>A p.A99T 17:7675200-7675200 27
2 COSM106128638 TP53 breast,NS,carcinoma,secretory c.412G>A p.A138T 17:7675200-7675200 27
3 COSM121958859 TP53 breast,NS,carcinoma,secretory c.16G>A p.A6T 17:7675200-7675200 27
4 COSM122817277 TP53 breast,NS,carcinoma,secretory c.16G>A p.A6T 17:7675200-7675200 27
5 COSM144376276 TP53 breast,NS,carcinoma,secretory c.295G>A p.A99T 17:7675200-7675200 27
6 COSM142638851 TP53 breast,NS,carcinoma,secretory c.295G>A p.A99T 17:7675200-7675200 27
7 COSM93261665 TP53 breast,NS,carcinoma,secretory c.412G>A p.A138T 17:7675200-7675200 27
8 COSM111840743 TP53 breast,NS,carcinoma,secretory c.412G>A p.A138T 17:7675200-7675200 27
9 COSM143224457 TP53 breast,NS,carcinoma,secretory c.-66G>A p.? 17:7675200-7675200 27
10 COSM144017112 TP53 breast,NS,carcinoma,secretory c.-66G>A p.? 17:7675200-7675200 27
11 COSM144152557 TP53 breast,NS,carcinoma,secretory c.-66G>A p.? 17:7675200-7675200 27
12 COSM105709638 TP53 breast,NS,carcinoma,secretory c.412G>A p.A138T 17:7675200-7675200 27
13 COSM142903561 TP53 breast,NS,carcinoma,secretory c.412G>A p.A138T 17:7675200-7675200 27
14 COSM145087547 TP53 breast,NS,carcinoma,secretory c.295G>A p.A99T 17:7675200-7675200 27
15 COSM122343382 TP53 breast,NS,carcinoma,secretory c.16G>A p.A6T 17:7675200-7675200 27
16 COSM143444930 TP53 breast,NS,carcinoma,secretory c.295G>A p.A99T 17:7675200-7675200 27
17 COSM144083566 TP53 breast,NS,carcinoma,secretory c.379G>A p.A127T 17:7675200-7675200 27
18 COSM87990610 TP53 breast,NS,carcinoma,secretory c.412G>A p.A138T 17:7675200-7675200 27
19 COSM112331177 TP53 breast,NS,carcinoma,secretory c.412G>A p.A138T 17:7675200-7675200 27
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Expression for Breast Secretory Carcinoma

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Search GEO for disease gene expression data for Breast Secretory Carcinoma.
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Pathways for Breast Secretory Carcinoma

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Pathways related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Immune response_Oncostatin M signaling via JAK-Stat in human cells 23
9.9 STAT5A SERPINA3
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GO Terms for Breast Secretory Carcinoma

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Biological processes related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 maintenance of gastrointestinal epithelium GO:0030277 8.62 SERPINA3 MUC4
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Sources for Breast Secretory Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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