SBC
MCID: BRS062
MIFTS: 41

Breast Secretory Carcinoma (SBC)

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Breast Secretory Carcinoma

MalaCards integrated aliases for Breast Secretory Carcinoma:

Name: Breast Secretory Carcinoma 12 15
Secretory Breast Carcinoma 53 44 73
Juvenile Secretory Carcinoma of Breast 12
Secretory Carcinoma of the Breast 53
Juvenile Carcinoma of the Breast 12
Juvenile Breast Carcinoma 12
Sbc 53

Classifications:



External Ids:

Disease Ontology 12 DOID:4922
MeSH 44 C537535
NCIt 50 C4189
SNOMED-CT 68 41919003
UMLS 73 C0334371

Summaries for Breast Secretory Carcinoma

NIH Rare Diseases : 53 Secretory breast carcinoma (SBC) is a very rare, slow-growing type of breast cancer. It was originally referred to as "juvenile breast carcinoma" because it was first recognized in children and adolescents. However, many cases reported in the last several decades have occurred in adults of all ages. SBC may occur in males or females but like other types of breast cancer, it is much more common in females. Signs and symptoms of SBC most commonly include a painless, firm mass in the breast, which may move when palpated. Some people with SBC also have nipple discharge. There is currently no consensus regarding treatment for SBC, and treatment options may depend on the person's age and the size of the tumor. Options may include surgery to remove the tumor or breast (mastectomy), surgery to also remove nearby lymph nodes, radiotherapy, and chemotherapy. SBC may recur in some cases, but when this happens, it is often in the same area of the breast and after a long period of time (called a late local recurrence). SBC is usually associated with an excellent prognosis (prolonged survival), even when it spreads (metastasizes) to the lymph nodes. The risk for SBC to spread to other parts of the body is thought to be extremely low.

MalaCards based summary : Breast Secretory Carcinoma, also known as secretory breast carcinoma, is related to breast cystic hypersecretory carcinoma and papilloma, and has symptoms including pain An important gene associated with Breast Secretory Carcinoma is NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3), and among its related pathways/superpathways are MAPK Signaling: Mitogen Stimulation Pathway and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include breast, lymph node and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A breast adenocarcinoma that has material basis in cells with abundant granular or clear vacuolated cytoplasm.

Related Diseases for Breast Secretory Carcinoma

Diseases related to Breast Secretory Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 breast cystic hypersecretory carcinoma 31.7 ERBB2 KRT5 LALBA TG
2 papilloma 29.9 KRT5 KRT7 KRT8
3 neural tube defects 11.2
4 adult mesoblastic nephroma 10.3 ETV6 NTRK3
5 pediatric fibrosarcoma 10.3 ETV6 NTRK3
6 primary hypereosinophilic syndrome 10.3 ETV6 FGFR1
7 breast cancer 10.2
8 adult fibrosarcoma 10.2 ETV6 NTRK3
9 breast osteosarcoma 10.2 ERBB2 KRT8
10 breast squamous cell carcinoma 10.2 ERBB2 KRT5
11 congenital fibrosarcoma 10.2 ETV6 NTRK3
12 scirrhous adenocarcinoma 10.2 ERBB2 PGR
13 breast apocrine carcinoma 10.2 ERBB2 PGR
14 glassy cell carcinoma of the cervix 10.2 ERBB2 PGR
15 inverted transitional papilloma 10.2 KRT5 KRT7
16 balloon cell malignant melanoma 10.2 KRT5 KRT7
17 intracystic papillary adenoma 10.2 ERBB2 PGR
18 benign breast adenomyoepithelioma 10.2 KRT5 KRT7
19 breast adenomyoepithelioma 10.2 KRT5 KRT7
20 ceruminoma 10.2 KRT5 KRT7
21 progesterone-receptor negative breast cancer 10.2 ERBB2 PGR
22 odontoma 10.2 KRT5 KRT8
23 malignant spiradenoma 10.2 KRT5 KRT7
24 breast medullary carcinoma 10.2 ERBB2 PGR
25 benign mesothelioma 10.2 KRT5 KRT7
26 breast scirrhous carcinoma 10.2 ERBB2 PGR
27 lymphoepithelioma-like thymic carcinoma 10.2 KRT5 TG
28 sensory organ benign neoplasm 10.2 KRT5 KRT7
29 middle ear adenoma 10.2 KRT5 KRT7
30 progesterone-receptor positive breast cancer 10.2 ERBB2 PGR
31 proliferating trichilemmal cyst 10.2 KRT7 KRT8
32 endolymphatic sac tumor 10.2 KRT7 KRT8
33 large cell acanthoma 10.2 KRT5 KRT7
34 breast adenoid cystic carcinoma 10.1 ERBB2 PGR
35 adenomyoma 10.1 KRT7 MUC4
36 chagas disease 10.1
37 adenoid squamous cell carcinoma 10.1 KRT7 KRT8
38 uterine body mixed cancer 10.1 ERBB2 PGR
39 nasal cavity cancer 10.1 KRT7 KRT8
40 eccrine papillary adenocarcinoma 10.1 KRT7 PGR
41 differentiated thyroid carcinoma 10.1 ETV6 NTRK3 TG
42 cervical clear cell adenocarcinoma 10.1 KRT5 KRT8 PGR
43 malignant biphasic mesothelioma 10.1 KRT5 KRT7
44 vulval paget's disease 10.1 ERBB2 KRT7
45 endosalpingiosis 10.1 KRT7 PGR
46 oncocytic breast carcinoma 10.1 KRT7 PGR
47 bile duct mucoepidermoid carcinoma 10.1 KRT5 KRT7 MUC4
48 microglandular adenosis 10.1 ERBB2 PGR
49 breast metaplastic carcinoma 10.1 ERBB2 KRT5 PGR
50 brooke-spiegler syndrome 10.1 KRT7 KRT8

Graphical network of the top 20 diseases related to Breast Secretory Carcinoma:



Diseases related to Breast Secretory Carcinoma

Symptoms & Phenotypes for Breast Secretory Carcinoma

UMLS symptoms related to Breast Secretory Carcinoma:


pain

GenomeRNAi Phenotypes related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

26 (show all 38)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.09 FGFR1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.09 SOX10
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.09 CDK4 SOX10
4 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.09 FGFR1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.09 FGFR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10.09 NTRK3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.09 NTRK3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.09 STAT5A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-152 10.09 NTRK3
10 Increased shRNA abundance (Z-score > 2) GR00366-A-158 10.09 STAT5A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.09 ERBB2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-163 10.09 ERBB2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.09 ERBB2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.09 FGFR1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.09 SOX10
16 Increased shRNA abundance (Z-score > 2) GR00366-A-183 10.09 FGFR1 LALBA STAT5A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.09 STAT5A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-207 10.09 ERBB2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.09 CDK4
20 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.09 LALBA NTRK3
21 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.09 ERBB2 SOX10
22 Increased shRNA abundance (Z-score > 2) GR00366-A-41 10.09 NTRK3
23 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.09 STAT5A CDK4 NTRK3
24 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.09 FGFR1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-46 10.09 CDK4
26 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.09 FGFR1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.09 SOX10
28 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.09 FGFR1
29 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.09 LALBA ERBB2
30 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.09 SOX10
31 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.09 SOX10
32 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.09 FGFR1 STAT5A
33 Increased shRNA abundance (Z-score > 2) GR00366-A-79 10.09 LALBA
34 Increased shRNA abundance (Z-score > 2) GR00366-A-8 10.09 LALBA
35 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.09 SOX10
36 Increased shRNA abundance (Z-score > 2) GR00366-A-83 10.09 FGFR1
37 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.09 STAT5A CDK4 ERBB2 NTRK3 SOX10
38 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.09 LALBA

MGI Mouse Phenotypes related to Breast Secretory Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.13 CDK4 CISH ERBB2 ETV6 FGFR1 LALBA
2 homeostasis/metabolism MP:0005376 10.11 CDK4 CISH ERBB2 ETV6 FGFR1 KRT7
3 growth/size/body region MP:0005378 10.1 CDK4 ERBB2 ETV6 FGFR1 KRT5 KRT8
4 digestive/alimentary MP:0005381 10.08 CDK4 ERBB2 ETV6 FGFR1 KRT5 KRT8
5 embryo MP:0005380 10 CDK4 ERBB2 ETV6 FGFR1 KRT8 PGR
6 integument MP:0010771 9.97 CDK4 ERBB2 ETV6 FGFR1 KRT5 LALBA
7 mortality/aging MP:0010768 9.85 CDK4 ERBB2 ETV6 FGFR1 KRT5 KRT8
8 limbs/digits/tail MP:0005371 9.73 ERBB2 FGFR1 KRT5 PGR SOX10 TG
9 no phenotypic analysis MP:0003012 9.43 ETV6 FGFR1 KRT5 NTRK3 PGR SOX10
10 normal MP:0002873 9.28 CDK4 ERBB2 ETV6 FGFR1 LALBA NTRK3

Drugs & Therapeutics for Breast Secretory Carcinoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 1/2 Study of LOXO-195 in Patients With Previously Treated NTRK Fusion Cancers Recruiting NCT03215511 Phase 1, Phase 2 LOXO-195

Search NIH Clinical Center for Breast Secretory Carcinoma

Cochrane evidence based reviews: secretory breast carcinoma

Genetic Tests for Breast Secretory Carcinoma

Anatomical Context for Breast Secretory Carcinoma

MalaCards organs/tissues related to Breast Secretory Carcinoma:

41
Breast, Lymph Node, Bone, Ovary, Thyroid, Thymus, Bone Marrow

Publications for Breast Secretory Carcinoma

Articles related to Breast Secretory Carcinoma:

(show all 29)
# Title Authors Year
1
Secretory breast carcinoma in an 8-year-old girl: A case report and literature review. ( 30251458 )
2018
2
Secretory breast carcinoma with a papillary-predominant pattern: an unusual morphological variant. ( 28383794 )
2017
3
Successful Targeted Therapy of Refractory Pediatric ETV6-NTRK3 Fusion-Positive Secretory Breast Carcinoma. ( 29623306 )
2017
4
Secretory Breast Carcinoma: A Histopathologic and Genomic Spectrum Characterized by a Joint Specific ETV6-NTRK3 Gene Fusion. ( 26291510 )
2015
5
Secretory breast carcinoma in a 6-year-old girl: mastectomy with sentinel lymph node dissection. ( 25994562 )
2015
6
A rare case of secretory breast carcinoma in a male adult with axillary lymph node metastasis. ( 26045861 )
2015
7
Secretory breast carcinoma in a 41-year-old man with long-term follow-up: a special report. ( 26075445 )
2015
8
Secretory breast carcinoma: A report of three cases and a review of the literature. ( 25009650 )
2014
9
Secretory breast carcinoma in a 12-year-old girl: A case report. ( 25202382 )
2014
10
Secretory breast carcinoma: a clinicopathological and immunophenotypic study of 15 cases with a review of the literature. ( 22157932 )
2012
11
ETV6 disruption does not predict indolent clinical behavior in secretory breast carcinoma. ( 23078524 )
2012
12
Long-term recurrence of secretory breast carcinoma with metastatic sentinel lymph nodes. ( 20838802 )
2011
13
Secretory breast carcinoma: unique, triple-negative carcinoma with a favorable prognosis and characteristic molecular expression. ( 22129193 )
2011
14
Secretory breast carcinoma in a 63-year-old man. ( 19292777 )
2009
15
A rare case of secretory breast carcinoma in an elderly woman: correlation of aspiration cytology and histology. ( 18306591 )
2007
16
Secretory breast carcinoma with metastatic sentinel lymph node. ( 17150092 )
2006
17
Painless breast lump in an elderly woman. Secretory breast carcinoma in an elderly woman. ( 16831040 )
2006
18
A fluorescence in situ hybridization study of ETV6-NTRK3 fusion gene in secretory breast carcinoma. ( 15101049 )
2004
19
Secretory breast carcinoma--case report and review of the medical literature. ( 15325674 )
2004
20
Secretory breast carcinoma with extensive intraductal component: case report. ( 15764584 )
2004
21
Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. ( 12450792 )
2002
22
Secretory breast carcinoma in a 9-year-old boy. ( 10711481 )
2000
23
Secretory breast carcinoma in a boy. ( 10188866 )
1999
24
Fine needle aspiration of secretory breast carcinoma resembling lactational changes. A case report. ( 9684599 )
1998
25
Secretory breast carcinoma in a 66 year old man. ( 9797736 )
1998
26
Secretory breast carcinoma in a man diagnosed by fine needle aspiration biopsy. A case report. ( 8191840 )
1994
27
Multicentric adult secretory breast carcinoma: DNA flow cytometric findings, prognostic features, and review of the world literature. ( 2200927 )
1990
28
Secretory breast carcinoma in a man. ( 3341512 )
1988
29
Tubular carcinoma: a variant of secretory breast carcinoma. ( 488923 )
1979

Variations for Breast Secretory Carcinoma

Cosmic variations for Breast Secretory Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM44821 TP53 breast,NS,carcinoma,secretory c.412G>A p.A138T 17:7675200-7675200 29

Expression for Breast Secretory Carcinoma

Search GEO for disease gene expression data for Breast Secretory Carcinoma.

Pathways for Breast Secretory Carcinoma

Pathways related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.74 CDK4 ERBB2 FGFR1 NTRK3
2
Show member pathways
11.58 KRT5 KRT7 KRT8
3
Show member pathways
11.53 ERBB2 PGR STAT5A
4 11.41 CDK4 ERBB2 FGFR1 NTRK3
5 11.14 ERBB2 FGFR1 NTRK3
6 10.45 ERBB2 FGFR1 NTRK3

GO Terms for Breast Secretory Carcinoma

Cellular components related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.65 CDK4 CISH ERBB2 ETV6 FGFR1 KRT5
2 keratin filament GO:0045095 8.8 KRT5 KRT7 KRT8

Biological processes related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 9.54 ERBB2 FGFR1 NTRK3
2 phosphatidylinositol phosphorylation GO:0046854 9.5 CISH ERBB2 FGFR1
3 cornification GO:0070268 9.43 KRT5 KRT7 KRT8
4 peptidyl-tyrosine phosphorylation GO:0018108 9.26 ERBB2 FGFR1 NTRK3 STAT5A
5 positive regulation of phospholipase C activity GO:0010863 9.16 FGFR1 NTRK3
6 negative regulation of signal transduction GO:0009968 8.92 CISH ERBB2 FGFR1 NTRK3

Molecular functions related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.13 ERBB2 FGFR1 NTRK3
2 protein tyrosine kinase activity GO:0004713 8.92 ERBB2 FGFR1 NTRK3 STAT5A

Sources for Breast Secretory Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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