Breast Secretory Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Breast Secretory Carcinoma

MalaCards integrated aliases for Breast Secretory Carcinoma:

Name: Breast Secretory Carcinoma ¹² ¹⁵

Secretory Breast Carcinoma ⁵⁴ ⁴⁵ ⁷⁴

Juvenile Secretory Carcinoma of Breast ¹²

Secretory Carcinoma of the Breast ⁵⁴

Juvenile Carcinoma of the Breast ¹²

Juvenile Breast Carcinoma ¹²

Sbc ⁵⁴

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4922

MeSH ⁴⁵ C537535

NCIt ⁵¹ C4189

SNOMED-CT ⁶⁹ 41919003

UMLS ⁷⁴ C0334371

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Summaries for Breast Secretory Carcinoma

NIH Rare Diseases : ⁵⁴ Secretory breast carcinoma (SBC) is a very rare, slow-growing type of breast cancer. It was originally referred to as "juvenile breast carcinoma" because it was first recognized in children and adolescents. However, many cases reported in the last several decades have occurred in adults of all ages. SBC may occur in males or females but like other types of breast cancer, it is much more common in females. Signs and symptoms of SBC most commonly include a painless, firm mass in the breast, which may move when palpated. Some people with SBC also have nipple discharge. There is currently no consensus regarding treatment for SBC, and treatment options may depend on the person's age and the size of the tumor. Options may include surgery to remove the tumor or breast (mastectomy), surgery to also remove nearby lymph nodes, radiotherapy, and chemotherapy. SBC may recur in some cases, but when this happens, it is often in the same area of the breast and after a long period of time (called a late local recurrence). SBC is usually associated with an excellent prognosis (prolonged survival), even when it spreads (metastasizes) to the lymph nodes. The risk for SBC to spread to other parts of the body is thought to be extremely low.

MalaCards based summary : Breast Secretory Carcinoma, also known as secretory breast carcinoma, is related to breast cystic hypersecretory carcinoma and papilloma, and has symptoms including pain An important gene associated with Breast Secretory Carcinoma is NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3), and among its related pathways/superpathways are Cytoskeletal Signaling and MAPK Signaling: Mitogen Stimulation Pathway. The drug 9-Fluoro-15-methyl-2,11,16,20,21,24-hexaazapentacyclo(16.5.2.02,6.07,12.021,2... has been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : ¹² A breast adenocarcinoma that has material basis in cells with abundant granular or clear vacuolated cytoplasm.

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Related Diseases for Breast Secretory Carcinoma

Diseases related to Breast Secretory Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)

#	Related Disease	Score	Top Affiliating Genes
1	breast cystic hypersecretory carcinoma	31.8	ERBB2 KRT5 LALBA TG
2	papilloma	30.1	KRT5 KRT7 KRT8
3	breast cancer	29.2	CDK4 ERBB2 FGFR1 KRT5 KRT8 MUC1
4	neural tube defects	11.3
5	adult mesoblastic nephroma	10.5	ETV6 NTRK3
6	primary hypereosinophilic syndrome	10.4	ETV6 FGFR1
7	pediatric fibrosarcoma	10.4	ETV6 NTRK3
8	breast osteosarcoma	10.3	ERBB2 KRT8
9	scirrhous adenocarcinoma	10.3	ERBB2 PGR
10	breast apocrine carcinoma	10.3	ERBB2 PGR
11	glassy cell carcinoma of the cervix	10.3	ERBB2 PGR
12	inverted transitional papilloma	10.3	KRT5 KRT7
13	balloon cell malignant melanoma	10.3	KRT5 KRT7
14	benign breast adenomyoepithelioma	10.3	KRT5 KRT7
15	ceruminoma	10.3	KRT5 KRT7
16	intracystic papillary adenoma	10.3	ERBB2 PGR
17	malignant spiradenoma	10.3	KRT5 KRT7
18	benign mesothelioma	10.3	KRT5 KRT7
19	progesterone-receptor negative breast cancer	10.3	ERBB2 PGR
20	adult fibrosarcoma	10.3	ETV6 NTRK3
21	proliferating trichilemmal cyst	10.3	KRT7 KRT8
22	endolymphatic sac tumor	10.3	KRT7 KRT8
23	breast medullary carcinoma	10.3	ERBB2 PGR
24	sensory organ benign neoplasm	10.3	KRT5 KRT7
25	large cell acanthoma	10.3	KRT5 KRT7
26	progesterone-receptor positive breast cancer	10.3	ERBB2 PGR
27	breast squamous cell carcinoma	10.3	ERBB2 KRT5
28	eccrine papillary adenocarcinoma	10.3	KRT7 PGR
29	adenoid squamous cell carcinoma	10.2	KRT7 KRT8
30	lymphoepithelioma-like thymic carcinoma	10.2	KRT5 TG
31	cervical clear cell adenocarcinoma	10.2	KRT5 KRT8 PGR
32	oncocytic breast carcinoma	10.2	KRT7 PGR
33	differentiated thyroid carcinoma	10.2	ETV6 NTRK3 TG
34	nasal cavity cancer	10.2	KRT7 KRT8
35	cribriform carcinoma	10.2	KRT7 PGR
36	benign metastasizing leiomyoma	10.2	KRT7 PGR
37	ovarian germ cell teratoma	10.2	KRT7 TG
38	breast metaplastic carcinoma	10.2	ERBB2 KRT5 PGR
39	ovarian germ cell cancer	10.2	KRT7 TG
40	uterine body mixed cancer	10.2	ERBB2 PGR
41	breast benign neoplasm	10.2	ERBB2 KRT5 PGR
42	vulval paget's disease	10.2	ERBB2 KRT7
43	thoracic benign neoplasm	10.2	ERBB2 KRT5 PGR
44	chronic ethmoiditis	10.2	MUC1 MUC4
45	breast adenoid cystic carcinoma	10.2	ERBB2 PGR
46	pancreatic serous cystadenoma	10.2	KRT7 PGR
47	pre-malignant neoplasm	10.2	ERBB2 KRT5 PGR
48	malignant mesenchymoma	10.2	CDK4 ETV6 NTRK3
49	in situ carcinoma	10.2	ERBB2 KRT5 PGR
50	chagas disease	10.2

Graphical network of the top 20 diseases related to Breast Secretory Carcinoma:

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Symptoms & Phenotypes for Breast Secretory Carcinoma

UMLS symptoms related to Breast Secretory Carcinoma:

pain

GenomeRNAi Phenotypes related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

²⁷ (show all 28)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-103	9.89	SOX10
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	9.89	CDK4 SOX10
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-116	9.89	CDK4 STAT5A
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-130	9.89	NTRK3
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-137	9.89	NTRK3
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-143	9.89	STAT5A
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-152	9.89	NTRK3
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-158	9.89	STAT5A
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-161	9.89	ERBB2
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-163	9.89	ERBB2
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-168	9.89	ERBB2
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.89	SOX10
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-183	9.89	STAT5A
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-190	9.89	STAT5A
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-207	9.89	ERBB2
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-21	9.89	CDK4
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-30	9.89	NTRK3
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	9.89	ERBB2 SOX10
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-41	9.89	NTRK3
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	9.89	CDK4 NTRK3 STAT5A
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-46	9.89	CDK4
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-49	9.89	SOX10
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.89	ERBB2
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-7	9.89	SOX10
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-70	9.89	SOX10
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	9.89	STAT5A
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-81	9.89	SOX10
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	9.89	CDK4 ERBB2 NTRK3 SOX10 STAT5A

MGI Mouse Phenotypes related to Breast Secretory Carcinoma:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	10.1	CDK4 CISH ERBB2 ETV6 FGFR1 LALBA
2	growth/size/body region	MP:0005378	10.07	CDK4 ERBB2 ETV6 FGFR1 KRT5 KRT8
3	digestive/alimentary	MP:0005381	10.06	CDK4 ERBB2 ETV6 FGFR1 KRT5 KRT8
4	homeostasis/metabolism	MP:0005376	10.06	CDK4 CISH ERBB2 ETV6 FGFR1 KRT7
5	embryo	MP:0005380	9.98	CDK4 ERBB2 ETV6 FGFR1 KRT8 PGR
6	integument	MP:0010771	9.91	CDK4 ERBB2 ETV6 FGFR1 KRT5 LALBA
7	limbs/digits/tail	MP:0005371	9.63	ERBB2 FGFR1 KRT5 PGR SOX10 TG
8	no phenotypic analysis	MP:0003012	9.43	ETV6 FGFR1 KRT5 NTRK3 PGR SOX10
9	normal	MP:0002873	9.28	CDK4 ERBB2 ETV6 FGFR1 LALBA NTRK3

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Drugs & Therapeutics for Breast Secretory Carcinoma

Drugs for Breast Secretory Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#		Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1		9-Fluoro-15-methyl-2,11,16,20,21,24-hexaazapentacyclo(16.5.2.02,6.07,12.021,2...		Phase 1, Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Phase 1/2 Study of LOXO-195 in Patients With Previously Treated NTRK Fusion Cancers	Recruiting	NCT03215511	Phase 1, Phase 2	LOXO-195

Search NIH Clinical Center for Breast Secretory Carcinoma

Cochrane evidence based reviews: secretory breast carcinoma

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Genetic Tests for Breast Secretory Carcinoma

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Anatomical Context for Breast Secretory Carcinoma

MalaCards organs/tissues related to Breast Secretory Carcinoma:

⁴²

Breast, Lymph Node, Thyroid, Bone, Spinal Cord, Bone Marrow, Thymus

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Publications for Breast Secretory Carcinoma

Articles related to Breast Secretory Carcinoma:

(show all 29)

#	Title	Authors	Year
1	Secretory breast carcinoma in an 8-year-old girl: A case report and literature review. ( 30251458 )	Garlick JW...Matsen CB	2018
2	Secretory breast carcinoma with a papillary-predominant pattern: an unusual morphological variant. ( 28383794 )	Shui R...Yang W	2017
3	Successful Targeted Therapy of Refractory Pediatric ETV6-NTRK3 Fusion-Positive Secretory Breast Carcinoma. ( 29623306 )	Shukla N...Hyman DM	2017
4	Secretory Breast Carcinoma: A Histopathologic and Genomic Spectrum Characterized by a Joint Specific ETV6-NTRK3 Gene Fusion. ( 26291510 )	Del Castillo M...MacGrogan G	2015
5	Secretory breast carcinoma in a 6-year-old girl: mastectomy with sentinel lymph node dissection. ( 25994562 )	Soyer T...Karnak ?	2015
6	A rare case of secretory breast carcinoma in a male adult with axillary lymph node metastasis. ( 26045861 )	Ding J...Wu W	2015
7	Secretory breast carcinoma in a 41-year-old man with long-term follow-up: a special report. ( 26075445 )	Li G...Yang S	2015
8	Secretory breast carcinoma in a 12-year-old girl: A case report. ( 25202382 )	Wang YQ...Yao Y	2014
9	Secretory breast carcinoma: A report of three cases and a review of the literature. ( 25009650 )	Lee SG...Bae JW	2014
10	ETV6 disruption does not predict indolent clinical behavior in secretory breast carcinoma. ( 23078524 )	Wong M...Wong NS	2012
11	Secretory breast carcinoma: a clinicopathological and immunophenotypic study of 15 cases with a review of the literature. ( 22157932 )	Li D...Shi D	2012
12	Secretory breast carcinoma: unique, triple-negative carcinoma with a favorable prognosis and characteristic molecular expression. ( 22129193 )	Vasudev P...Onuma K	2011
13	Long-term recurrence of secretory breast carcinoma with metastatic sentinel lymph nodes. ( 20838802 )	Tixier H...Cuisenier J	2011
14	Secretory breast carcinoma in a 63-year-old man. ( 19292777 )	Iglesias B...Ant?n I	2009
15	A rare case of secretory breast carcinoma in an elderly woman: correlation of aspiration cytology and histology. ( 18306591 )	Mardi K...Sharma J	2007
16	Secretory breast carcinoma with metastatic sentinel lymph node. ( 17150092 )	Vieni S...Latteri MA	2006
17	Painless breast lump in an elderly woman. Secretory breast carcinoma in an elderly woman. ( 16831040 )	Yaqoob N...ul Hasan SH	2006
18	A fluorescence in situ hybridization study of ETV6-NTRK3 fusion gene in secretory breast carcinoma. ( 15101049 )	Makretsov N...Huntsman DG	2004
19	Secretory breast carcinoma--case report and review of the medical literature. ( 15325674 )	Costa NM...Matos E	2004
20	Secretory breast carcinoma with extensive intraductal component: case report. ( 15764584 )	Celik A...Cetin A	2004
21	Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. ( 12450792 )	Tognon C...Sorensen PH	2002
22	Secretory breast carcinoma in a 9-year-old boy. ( 10711481 )	Titus J...Fenton LE	2000
23	Secretory breast carcinoma in a boy. ( 10188866 )	Yildirim E...Berbero?lu U	1999
24	Fine needle aspiration of secretory breast carcinoma resembling lactational changes. A case report. ( 9684599 )	Vesoulis Z...Kashkari S	1998
25	Secretory breast carcinoma in a 66 year old man. ( 9797736 )	Kuwabara H...Okada S	1998
26	Secretory breast carcinoma in a man diagnosed by fine needle aspiration biopsy. A case report. ( 8191840 )	Pohar-Marinsek Z...Golouh R	1994
27	Multicentric adult secretory breast carcinoma: DNA flow cytometric findings, prognostic features, and review of the world literature. ( 2200927 )	Richard G...Austin RM	1990
28	Secretory breast carcinoma in a man. ( 3341512 )	Roth JA...O'Malley M	1988
29	Tubular carcinoma: a variant of secretory breast carcinoma. ( 488923 )	Eusebi V...Bussolati G	1979

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Genes for Breast Secretory Carcinoma

Genes related to Breast Secretory Carcinoma (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NTRK3	Neurotrophic Receptor Tyrosine Kinase 3	Protein Coding	17.03	DISEASES inferred ¹⁵
2	ETV6	ETS Variant 6	Protein Coding	16.62	DISEASES inferred ¹⁵
3	MUC4	Mucin 4, Cell Surface Associated	Protein Coding	15.07	DISEASES inferred ¹⁵
4	KRT5	Keratin 5	Protein Coding	14.42	DISEASES inferred ¹⁵
5	SOX10	SRY-Box 10	Protein Coding	14.09	DISEASES inferred ¹⁵
6	CISH	Cytokine Inducible SH2 Containing Protein	Protein Coding	14.02	DISEASES inferred ¹⁵
7	KRT8	Keratin 8	Protein Coding	13.72	DISEASES inferred ¹⁵
8	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	13.53	DISEASES inferred ¹⁵
9	PGR	Progesterone Receptor	Protein Coding	13.49	DISEASES inferred ¹⁵
10	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	13.46	DISEASES inferred ¹⁵
11	TG	Thyroglobulin	Protein Coding	13.16	DISEASES inferred ¹⁵
12	KRT7	Keratin 7	Protein Coding	13.07	DISEASES inferred ¹⁵
13	CDK4	Cyclin Dependent Kinase 4	Protein Coding	13.02	DISEASES inferred ¹⁵
14	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	12.96	DISEASES inferred ¹⁵
15	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	4.38	DISEASES inferred ¹⁵
16	LALBA	Lactalbumin Alpha	Protein Coding	3.15	DISEASES inferred ¹⁵

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Variations for Breast Secretory Carcinoma

Cosmic variations for Breast Secretory Carcinoma:

⁹

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM44821	TP53	breast,NS,carcinoma,secretory	c.412G>A	p.A138T	17:7675200-7675200	0

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Expression for Breast Secretory Carcinoma

Search GEO for disease gene expression data for Breast Secretory Carcinoma.

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Pathways for Breast Secretory Carcinoma

Pathways related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cytoskeletal Signaling ⁴	12.11	KRT5 KRT7 KRT8 MUC1
2	MAPK Signaling: Mitogen Stimulation Pathway ⁶⁶ Show member pathways Akt Signaling Pathway ⁶⁶	11.74	CDK4 ERBB2 FGFR1 NTRK3
3	Cytoskeleton remodeling Neurofilaments ²³ Show member pathways Cytoskeleton remodeling Keratin filaments ²³	11.61	KRT5 KRT7 KRT8
4	Signaling by ERBB4 ⁶⁷ Show member pathways Downregulation of ERBB4 signaling ⁶⁷ ErbB4 signaling events ¹ Nuclear signaling by ERBB4 ⁶⁷	11.58	ERBB2 PGR STAT5A
5	AKT Signaling Pathway ⁶⁸	11.41	CDK4 ERBB2 FGFR1 NTRK3
6	Central carbon metabolism in cancer ³⁸	11.14	ERBB2 FGFR1 NTRK3
7	Alzheimers Disease Pathway ⁶⁵	10.45	ERBB2 FGFR1 NTRK3

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GO Terms for Breast Secretory Carcinoma

Cellular components related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Golgi lumen	GO:0005796	9.13	LALBA MUC1 MUC4
2	keratin filament	GO:0045095	8.8	KRT5 KRT7 KRT8

Biological processes related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of MAPK cascade	GO:0043410	9.54	ERBB2 FGFR1 NTRK3
2	cornification	GO:0070268	9.43	KRT5 KRT7 KRT8
3	positive regulation of phospholipase C activity	GO:0010863	9.16	FGFR1 NTRK3
4	peptidyl-tyrosine phosphorylation	GO:0018108	9.13	ERBB2 FGFR1 NTRK3
5	phosphatidylinositol phosphorylation	GO:0046854	9.02	CISH
6	negative regulation of signal transduction	GO:0009968	8.32	CISH

Molecular functions related to Breast Secretory Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane receptor protein tyrosine kinase activity	GO:0004714	9.13	ERBB2 FGFR1 NTRK3
2	protein tyrosine kinase activity	GO:0004713	8.8	ERBB2 FGFR1 NTRK3

Sources

Sources for Breast Secretory Carcinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia