MCID: BRS063
MIFTS: 39

Breast Squamous Cell Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Breast Squamous Cell Carcinoma

MalaCards integrated aliases for Breast Squamous Cell Carcinoma:

Name: Breast Squamous Cell Carcinoma 12 15
Primary Squamous Cell Carcinoma of the Breast 12
Primary Squamous Cell Carcinoma of Breast 12
Breast Primary Squamous Cell Carcinoma 12
Squamous Cell Carcinoma of Breast 12
Squamous Cell Breast Carcinoma 17
Scc of Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5514
NCIt 51 C5177
UMLS 74 C1336079

Summaries for Breast Squamous Cell Carcinoma

Disease Ontology : 12 A breast metaplastic carcinoma that arises from squamous epithelial cells.

MalaCards based summary : Breast Squamous Cell Carcinoma, also known as primary squamous cell carcinoma of the breast, is related to in situ carcinoma and squamous cell carcinoma. An important gene associated with Breast Squamous Cell Carcinoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Developmental Biology. Affiliated tissues include breast, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Related Diseases for Breast Squamous Cell Carcinoma

Diseases related to Breast Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
# Related Disease Score Top Affiliating Genes
1 in situ carcinoma 29.1 EGFR ERBB2 KRT14 KRT5 TP53
2 squamous cell carcinoma 29.1 EGFR ERBB2 PIK3CA PTHLH TP53
3 breast cancer 28.4 EGFR ERBB2 KRT14 KRT5 PIK3CA PTHLH
4 acantholytic variant squamous cell breast carcinoma 11.2
5 spindle cell variant squamous cell breast carcinoma 11.2
6 large cell keratinizing variant squamous cell breast carcinoma 11.2
7 ovarian clear cell carcinoma 10.4 PIK3CA TP53
8 skin squamous cell carcinoma 10.4 PIK3CA TP53
9 fallopian tube carcinoma 10.4 ERBB2 TP53
10 barrett's adenocarcinoma 10.4 ERBB2 TP53
11 granulosa cell tumor of the ovary 10.4 ERBB2 TP53
12 adult hepatocellular carcinoma 10.3 PIK3CA TP53
13 rare adenocarcinoma of the breast 10.3 PIK3CA TP53
14 keratoacanthoma 10.3 KRT10 TP53
15 gastric papillary adenocarcinoma 10.3 ERBB2 TP53
16 keratinizing squamous cell carcinoma 10.3 KRT5 TP53
17 papillary adenocarcinoma 10.3 ERBB2 TP53
18 anal squamous cell carcinoma 10.3 PIK3CA TP53
19 brain glioma 10.3 EGFR TP53
20 vulva cancer 10.3 EGFR TP53
21 laryngeal disease 10.3 EGFR TP53
22 pleomorphic adenoma carcinoma 10.3 ERBB2 TP53
23 spiradenoma 10.3 KRT14 TP53
24 non-proliferative fibrocystic change of the breast 10.3 ERBB2 TP53
25 spinal chordoma 10.3 EGFR PIK3CA
26 breast cystic hypersecretory carcinoma 10.3 ERBB2 KRT5
27 breast metaplastic carcinoma 10.3 ERBB2 KRT5
28 vulvar intraepithelial neoplasia 10.3 KRT10 TP53
29 spindle cell carcinoma 10.3 KRT14 KRT5
30 prostate squamous cell carcinoma 10.3 KRT5 TP53
31 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.2 PIK3CA TP53
32 brain ependymoma 10.2 EGFR TP53
33 glioma susceptibility 1 10.2 ERBB2 TP53
34 exanthem 10.2 EGFR ERBB2
35 apocrine adenocarcinoma 10.2 ERBB2 KRT5
36 mammary paget's disease 10.2 EGFR ERBB2
37 gallbladder adenocarcinoma 10.2 EGFR ERBB2
38 thyroid hurthle cell adenoma 10.2 KRT14 PIK3CA
39 keratocystic odontogenic tumor 10.2 PTHLH TP53
40 squamous cell carcinoma of the oral tongue 10.2 KRT10 PIK3CA
41 esophagus adenocarcinoma 10.2 ERBB2 TP53
42 recurrent respiratory papillomatosis 10.2 EGFR TP53
43 fibroepithelial basal cell carcinoma 10.2 KRT14 TP53
44 palmoplantar keratoderma, epidermolytic 10.2 KRT10 KRT14
45 white sponge nevus 1 10.2 KRT10 KRT14
46 hidradenitis suppurativa 10.2 KRT10 KRT14
47 hidradenitis 10.2 KRT10 KRT14
48 breast intraductal proliferative lesion 10.2 EGFR ERBB2
49 lichen planopilaris 10.2 KRT14 KRT5
50 epidermolysis bullosa simplex, autosomal recessive 1 10.2 KRT14 KRT5

Graphical network of the top 20 diseases related to Breast Squamous Cell Carcinoma:



Diseases related to Breast Squamous Cell Carcinoma

Symptoms & Phenotypes for Breast Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Breast Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.8 EGFR ERBB2
2 Decreased viability with paclitaxel GR00179-A-3 8.8 EGFR

MGI Mouse Phenotypes related to Breast Squamous Cell Carcinoma:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.04 CD86 EGFR ERBB2 KRT14 PIK3CA PTHLH
2 endocrine/exocrine gland MP:0005379 9.98 CD86 EGFR ERBB2 KRT14 PIK3CA PTHLH
3 craniofacial MP:0005382 9.95 EGFR ERBB2 KRT14 KRT5 PTHLH TP53
4 growth/size/body region MP:0005378 9.95 EGFR ERBB2 KRT14 KRT5 PIK3CA PTHLH
5 digestive/alimentary MP:0005381 9.93 EGFR ERBB2 KRT14 KRT5 PTHLH TP53
6 adipose tissue MP:0005375 9.91 EGFR KRT14 PIK3CA PTHLH TP53
7 integument MP:0010771 9.91 EGFR ERBB2 KRT14 KRT5 PIK3CA PTHLH
8 limbs/digits/tail MP:0005371 9.72 EGFR ERBB2 KRT5 PTHLH TP53
9 muscle MP:0005369 9.65 CD86 EGFR ERBB2 PIK3CA TP53
10 neoplasm MP:0002006 9.63 EGFR ERBB2 KRT14 PIK3CA PTHLH TP53
11 reproductive system MP:0005389 9.43 EGFR ERBB2 KRT14 PIK3CA PTHLH TP53
12 respiratory system MP:0005388 9.02 EGFR ERBB2 KRT14 PTHLH TP53

Drugs & Therapeutics for Breast Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Squamous Cell Carcinoma

Genetic Tests for Breast Squamous Cell Carcinoma

Anatomical Context for Breast Squamous Cell Carcinoma

MalaCards organs/tissues related to Breast Squamous Cell Carcinoma:

42
Breast

Publications for Breast Squamous Cell Carcinoma

Articles related to Breast Squamous Cell Carcinoma:

(show all 43)
# Title Authors Year
1
Change of HER2 status during disease recurrence predicts good prognosis for primary squamous cell carcinoma of the breast: A case report. ( 30817587 )
2019
2
Breast Squamous Cell Carcinoma Following Breast Augmentation. ( 30533339 )
2018
3
Management and prognosis of pure primary squamous cell carcinoma of the breast. ( 29959086 )
2018
4
A case of primary squamous cell carcinoma of the breast with pathologic complete response after neoadjuvant chemotherapy. ( 29880396 )
2018
5
Estrogen receptor-positive primary squamous cell carcinoma of the breast. ( 28491153 )
2017
6
Intracystic Primary Squamous Cell Carcinoma of the Breast: A Challenging Diagnosis. ( 27747114 )
2016
7
Clinicopathologic characteristics and prognosis of primary squamous cell carcinoma of the breast. ( 25476498 )
2015
8
Primary squamous cell carcinoma of the breast: a case report and review of literature. ( 27386028 )
2015
9
Primary squamous cell carcinoma of the breast. ( 24600581 )
2014
10
Primary squamous cell carcinoma of the breast with unusual basal-HER2 phenotype. ( 25197398 )
2014
11
Primary squamous cell carcinoma of the breast: predictors of locoregional recurrence and overall survival. ( 23629447 )
2013
12
Primary squamous cell carcinoma of the breast: case report and management decisions. ( 22842389 )
2012
13
Pure primary squamous cell carcinoma of the breast presenting as an intracystic tumor. ( 23009559 )
2012
14
Primary squamous cell carcinoma of the breast: A rare case report. ( 24377039 )
2012
15
Pure Primary Squamous Cell Carcinoma of the Breast Arising from the Epithelium of a Complex Mammary Cyst: A Case Report. ( 21461996 )
2011
16
Primary Squamous Cell Carcinoma of the Breast during Pregnancy: A Case Report. ( 22229037 )
2011
17
Primary squamous cell carcinoma of the breast: achieving long-term control with cisplatin-based chemotherapy. ( 19661044 )
2009
18
Pure primary squamous cell carcinoma of the breast: a rare presentation and clinicopathologic comparison with usual ductal carcinoma of the breast. ( 16497446 )
2006
19
Abscess as initial presentation of pure primary squamous cell carcinoma of the breast. ( 16800983 )
2006
20
Primary squamous cell carcinoma of the breast in an adult woman. ( 17238990 )
2006
21
Primary squamous cell carcinoma of the breast: value of positron emission tomography scanning in confirming the diagnosis. ( 17239268 )
2006
22
Primary squamous cell carcinoma of the breast: a case report. ( 16555631 )
2005
23
Primary squamous cell carcinoma of the breast. ( 14584651 )
2003
24
MR mammography of a primary squamous cell carcinoma of the breast: a case report. ( 14659329 )
2003
25
Primary squamous cell carcinoma of the breast. ( 11906428 )
2002
26
Primary squamous cell carcinoma of the breast during lactation: a case report. ( 10939434 )
2000
27
A case of primary squamous cell carcinoma of the breast with rapid progression. ( 11029790 )
2000
28
Primary squamous cell carcinoma of the breast presenting as a breast abscess. ( 10597064 )
1999
29
Primary squamous cell carcinoma of the breast in a young woman--a case report and review of literature. ( 9866914 )
1998
30
Primary squamous cell carcinoma of the breast. ( 8638180 )
1996
31
Primary squamous cell carcinoma of the breast: sensitivity to cisplatinum-based chemotherapy. ( 7609529 )
1995
32
Primary squamous cell carcinoma of the breast presenting as a nipple discharge. ( 8291348 )
1994
33
Primary squamous cell carcinoma of the breast in a pregnant woman: report of a case. ( 8395267 )
1993
34
Primary squamous cell carcinoma of the breast after cured Hodgkin's disease. ( 8461611 )
1993
35
Primary squamous cell carcinoma of the breast. ( 1310819 )
1992
36
Primary squamous cell carcinoma of the breast. ( 1445110 )
1992
37
Primary squamous cell carcinoma of the breast: mammographic findings. ( 2766024 )
1989
38
A case of pure primary squamous cell carcinoma of the breast diagnosed by fine needle aspiration biopsy. ( 3169921 )
1988
39
Magnetic resonance imaging appearance of primary squamous cell carcinoma of the breast. ( 3327657 )
1987
40
A case of pure primary squamous-cell carcinoma of the breast diagnosed by fine needle aspiration biopsy. ( 3861059 )
1985
41
Primary squamous-cell carcinoma of the breast. Diagnosis by fine needle aspiration cytology. ( 6587708 )
1984
42
Primary squamous cell carcinoma of the breast arising within an abscess. ( 7142721 )
1982
43
Primary squamous cell carcinoma of the breast. ( 7284964 )
1981

Variations for Breast Squamous Cell Carcinoma

Expression for Breast Squamous Cell Carcinoma

Search GEO for disease gene expression data for Breast Squamous Cell Carcinoma.

Pathways for Breast Squamous Cell Carcinoma

Pathways related to Breast Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.26 CD86 EGFR ERBB2 PIK3CA TP53
2
Show member pathways
13.26 EGFR ERBB2 KRT10 KRT14 KRT5 PIK3CA
3
Show member pathways
13.15 CD86 EGFR ERBB2 PIK3CA TP53
4
Show member pathways
12.85 EGFR KRT10 KRT14 PIK3CA
5
Show member pathways
12.8 EGFR ERBB2 PIK3CA TP53
6
Show member pathways
12.78 CD86 EGFR PIK3CA TP53
7
Show member pathways
12.68 EGFR ERBB2 PIK3CA TP53
8 12.66 EGFR ERBB2 PIK3CA TP53
9
Show member pathways
12.57 EGFR ERBB2 PIK3CA TP53
10
Show member pathways
12.51 EGFR ERBB2 PIK3CA TP53
11
Show member pathways
12.39 EGFR ERBB2 PIK3CA TP53
12
Show member pathways
12.33 EGFR ERBB2 PIK3CA TP53
13 12.31 EGFR ERBB2 PIK3CA TP53
14
Show member pathways
12.29 EGFR ERBB2 PIK3CA TP53
15
Show member pathways
12.29 CD86 EGFR ERBB2 PIK3CA TP53
16
Show member pathways
12.16 EGFR ERBB2 PIK3CA
17
Show member pathways
12.13 EGFR ERBB2 PIK3CA
18
Show member pathways
12.13 EGFR ERBB2 PIK3CA TP53
19
Show member pathways
11.98 EGFR ERBB2 PIK3CA
20 11.97 EGFR ERBB2 PIK3CA TP53
21
Show member pathways
11.96 EGFR ERBB2 PIK3CA
22
Show member pathways
11.92 EGFR ERBB2 PIK3CA TP53
23 11.83 ERBB2 PIK3CA TP53
24
Show member pathways
11.79 EGFR ERBB2 PIK3CA
25 11.78 EGFR ERBB2 PIK3CA TP53
26 11.75 EGFR ERBB2 PIK3CA
27 11.64 KRT14 KRT5 TP53
28 11.55 EGFR ERBB2 TP53
29 11.53 ERBB2 PIK3CA TP53
30
Show member pathways
11.46 EGFR ERBB2 PIK3CA
31 11.45 ERBB2 PIK3CA TP53
32
Show member pathways
11.35 EGFR ERBB2 PIK3CA TP53
33
Show member pathways
11.31 EGFR PIK3CA
34 11.24 EGFR ERBB2 PIK3CA
35 11.21 EGFR PIK3CA
36 11.19 EGFR TP53
37
Show member pathways
11.19 PIK3CA PTHLH
38 11.14 EGFR ERBB2
39 11.08 EGFR PIK3CA
40 11.04 EGFR PIK3CA
41 10.91 EGFR PIK3CA
42 10.82 EGFR ERBB2 PIK3CA
43 10.74 EGFR ERBB2 PIK3CA TP53

GO Terms for Breast Squamous Cell Carcinoma

Cellular components related to Breast Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basal plasma membrane GO:0009925 8.96 EGFR ERBB2
2 intermediate filament GO:0005882 8.8 KRT10 KRT14 KRT5

Biological processes related to Breast Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.7 CD86 EGFR ERBB2
2 keratinization GO:0031424 9.63 KRT10 KRT14 KRT5
3 cornification GO:0070268 9.58 KRT10 KRT14 KRT5
4 positive regulation of protein kinase B signaling GO:0051897 9.56 CD86 EGFR ERBB2 PIK3CA
5 phosphatidylinositol 3-kinase signaling GO:0014065 9.51 ERBB2 PIK3CA
6 regulation of cell motility GO:2000145 9.49 EGFR ERBB2
7 regulation of ERK1 and ERK2 cascade GO:0070372 9.48 EGFR ERBB2
8 hemidesmosome assembly GO:0031581 9.43 KRT14 KRT5
9 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.37 EGFR TP53
10 ERBB2 signaling pathway GO:0038128 9.33 EGFR ERBB2 PIK3CA
11 negative regulation of ERBB signaling pathway GO:1901185 9.32 EGFR ERBB2
12 phosphatidylinositol phosphorylation GO:0046854 9.26 CD86 EGFR ERBB2 PIK3CA
13 epidermis development GO:0008544 8.92 EGFR KRT14 KRT5 PTHLH

Molecular functions related to Breast Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.46 EGFR ERBB2 KRT10 TP53
2 protein phosphatase binding GO:0019903 9.13 EGFR ERBB2 TP53
3 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.92 CD86 EGFR ERBB2 PIK3CA

Sources for Breast Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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