MCID: BRS063
MIFTS: 27

Breast Squamous Cell Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Breast Squamous Cell Carcinoma

MalaCards integrated aliases for Breast Squamous Cell Carcinoma:

Name: Breast Squamous Cell Carcinoma 12 15
Primary Squamous Cell Carcinoma of the Breast 12
Primary Squamous Cell Carcinoma of Breast 12
Breast Primary Squamous Cell Carcinoma 12
Squamous Cell Carcinoma of Breast 12
Squamous Cell Breast Carcinoma 17
Scc of Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5514
NCIt 50 C5177
UMLS 70 C1336079

Summaries for Breast Squamous Cell Carcinoma

Disease Ontology : 12 A breast metaplastic carcinoma that arises from squamous epithelial cells.

MalaCards based summary : Breast Squamous Cell Carcinoma, also known as primary squamous cell carcinoma of the breast, is related to keratinizing squamous cell carcinoma and bilateral breast cancer. An important gene associated with Breast Squamous Cell Carcinoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are RNA Polymerase III Transcription Initiation and Platinum drug resistance. Affiliated tissues include breast, thymus and ovary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Breast Squamous Cell Carcinoma

Diseases related to Breast Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 keratinizing squamous cell carcinoma 30.5 TP53 KRT5
2 bilateral breast cancer 30.4 TP53 ERBB2
3 mature teratoma 30.3 TP53 ERBB2
4 in situ carcinoma 30.0 TP53 KRT5 ERBB2
5 ductal carcinoma in situ 30.0 TP53 KRT5 ERBB2
6 breast ductal carcinoma 29.7 TP53 KRT5 ERBB2
7 acantholytic variant squamous cell breast carcinoma 11.2
8 spindle cell variant squamous cell breast carcinoma 11.2
9 large cell keratinizing variant squamous cell breast carcinoma 11.2
10 rare tumor 10.6
11 breast abscess 10.3
12 breast cyst 10.3
13 adenoid squamous cell carcinoma 10.3
14 adenosquamous carcinoma 10.2 TP53 KRT5
15 mucoepidermoid esophageal carcinoma 10.2 TP53 KRT5
16 basaloid lung carcinoma 10.2 TP53 KRT5
17 necrotizing sialometaplasia 10.2 TP53 KRT5
18 large cell acanthoma 10.2 TP53 KRT5
19 acanthoma 10.2 TP53 KRT5
20 eccrine sweat gland cancer 10.2 TP53 KRT5
21 cystadenofibroma 10.2 TP53 KRT5
22 clear cell basal cell carcinoma 10.2 TP53 KRT5
23 papillary adenoma 10.2 TP53 KRT5
24 urethral benign neoplasm 10.2 TP53 KRT5
25 malignant spiradenoma 10.2 TP53 KRT5
26 nasal cavity cancer 10.2 TP53 KRT5
27 borst-jadassohn intraepidermal carcinoma 10.2 TP53 KRT5
28 sweat gland benign neoplasm 10.2 TP53 KRT5
29 peritoneum cancer 10.1 TP53 KRT5
30 benign teratoma 10.1
31 mastitis 10.1
32 cystic teratoma 10.1
33 breast adenocarcinoma 10.1
34 tubular adenocarcinoma 10.1
35 fibromatosis 10.1
36 zuska's disease 10.1
37 rare breast tumor 10.1
38 squamous cell carcinoma 10.1
39 inverted papilloma 10.1 TP53 KRT5
40 verrucous carcinoma 10.1 TP53 KRT5
41 keratosis, seborrheic 10.1 TP53 KRT5
42 benign breast phyllodes tumor 10.1
43 rare malignant breast tumor 10.1
44 thymus gland disease 10.1 TP53 KRT5
45 gastric papillary adenocarcinoma 10.1 TP53 ERBB2
46 papillary adenocarcinoma 10.1 TP53 ERBB2
47 thymus cancer 10.1 TP53 KRT5
48 apocrine adenosis of breast 10.1 TP53 ERBB2
49 comedo carcinoma 10.1 TP53 ERBB2
50 pleomorphic adenoma carcinoma 10.1 TP53 ERBB2

Graphical network of the top 20 diseases related to Breast Squamous Cell Carcinoma:



Diseases related to Breast Squamous Cell Carcinoma

Symptoms & Phenotypes for Breast Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Breast Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.5 GTF3A
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-129 9.5 GTF3A
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.5 ERBB2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-159 9.5 GTF3A
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-16 9.5 GTF3C1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-163 9.5 ERBB2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-201 9.5 GTF3A
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.5 GTF3A GTF3C1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-214 9.5 GTF3C1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-23 9.5 GTF3A
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-25 9.5 GTF3C1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-46 9.5 GTF3A
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.5 GTF3C1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.5 GTF3A

Drugs & Therapeutics for Breast Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Breast Squamous Cell Carcinoma

Genetic Tests for Breast Squamous Cell Carcinoma

Anatomical Context for Breast Squamous Cell Carcinoma

MalaCards organs/tissues related to Breast Squamous Cell Carcinoma:

40
Breast, Thymus, Ovary, Lymph Node, Small Intestine, Lung, Salivary Gland

Publications for Breast Squamous Cell Carcinoma

Articles related to Breast Squamous Cell Carcinoma:

(show all 28)
# Title Authors PMID Year
1
Metaplastic breast carcinoma: a retrospective study of 26 cases. 61
33786152 2021
2
[Acantholytic variant of squamous cell carcinoma of breast: report of a case]. 61
32392937 2020
3
SOX10 - A Novel Marker for the Differential Diagnosis of Breast Metaplastic Squamous Cell Carcinoma. 61
32547236 2020
4
Case Report: A Simple Thoraco - Abdominal Flap to Reconstruct Wide Defect of Radical Mastectomy in Squamous Cell Carcinoma of Breast. 61
31110585 2019
5
Squamous Cell Carcinoma of the Breast. 61
30266123 2018
6
Breast Squamous Cell Carcinoma Following Breast Augmentation. 61
30533339 2018
7
Sebaceous Carcinoma in Situ Masquerading Clinically and Histologically as Paget Disease of the Breast. 61
30110525 2018
8
Metaplastic Squamous Cell Carcinoma of Breast Demonstrated on 18F-FDG PET/CT. 61
29432344 2018
9
Identification and Validation of a PD-L1 Binding Peptide for Determination of PDL1 Expression in Tumors. 61
29057919 2017
10
Squamous cell carcinoma of the breast in the United States: incidence, demographics, tumor characteristics, and survival. 61
28432512 2017
11
Clinical features and treatment of squamous cell carcinoma of the breast. 61
27313463 2016
12
[Squamous cell carcinoma of the breast: report of a case and review of the literature]. 61
27800068 2016
13
Metaplastic squamous cell carcinoma of breast. A pathology case report with review of literature. 61
26160092 2015
14
Activated leukocyte cell adhesion molecule (ALCAM/CD166) expression in head and neck squamous cell carcinoma (HNSSC). 61
25028217 2014
15
Primary squamous cell carcinoma of breast presenting as a cystic mass. 61
23793323 2013
16
Primary squamous cell carcinoma of the breast: case report and management decisions. 61
22842389 2012
17
[Pure primary breast squamous cell carcinoma]. 61
22856407 2011
18
Primary squamous cell carcinoma of breast with ipsilateral axillary lymph node metastasis: An unusual case. 61
22096725 2011
19
Acantholytic variant of squamous cell carcinoma of breast: a rare case report. 61
22276057 2011
20
[Primary squamous cell carcinoma of breast: report of 2 cases]. 61
21055185 2010
21
Primary squamous cell carcinoma of breast in background of phyllodes tumor--a case report. 61
19637664 2009
22
Optimum parameters in a model for tumour control probability, including interpatient heterogeneity: evaluation of the log-normal distribution. 61
17183142 2007
23
Squamous cell carcinoma of breast--report of two case. 61
15025377 2003
24
Squamous cell carcinoma of breast. 61
11832647 2001
25
Pure squamous cell carcinoma of the breast in a patient with previous adenocarcinoma of the breast: a case report and review of the literature. 61
11450786 2001
26
Primary squamous cell carcinoma of breast (a case report). 61
3273586 1987
27
Pharmacology, clinical efficacy and adverse effects of vindesine sulfate, a new vinca alkaloid. 61
6359081 1983
28
Primary squamous-cell carcinoma of breast with pseudosarcomatous stroma. 61
5352811 1969

Variations for Breast Squamous Cell Carcinoma

Expression for Breast Squamous Cell Carcinoma

Search GEO for disease gene expression data for Breast Squamous Cell Carcinoma.

Pathways for Breast Squamous Cell Carcinoma

GO Terms for Breast Squamous Cell Carcinoma

Biological processes related to Breast Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase III GO:0006383 8.96 GTF3C1 GTF3A
2 rRNA transcription GO:0009303 8.8 TP53 GTF3C1 GTF3A

Sources for Breast Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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