MCID: BRL001
MIFTS: 25

Brill-Zinsser Disease

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Brill-Zinsser Disease

MalaCards integrated aliases for Brill-Zinsser Disease:

Name: Brill-Zinsser Disease 12 59 15 17 72
Recrudescent Typhus 12 59
Typhus, Epidemic Louse-Borne 44
Brill Zinsser Disease 12
Brill's Disease 12
Sporadic Typhus 12
Latent Typhus 12
Brill Disease 59

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11254
ICD9CM 35 081.1
MeSH 44 D014438
SNOMED-CT 68 47761007
ICD10 33 A75.1
ICD10 via Orphanet 34 A75.1
UMLS via Orphanet 73 C0006181
Orphanet 59 ORPHA99990
UMLS 72 C0006181

Summaries for Brill-Zinsser Disease

Disease Ontology : 12 An epidemic typhus that is a mild form of the disease, which recurs in someone after a long period of latency due to immunosuppression, malnutrition or other illnesses.

MalaCards based summary : Brill-Zinsser Disease, also known as recrudescent typhus, is related to epidemic typhus and typhus-group rickettsiosis. An important gene associated with Brill-Zinsser Disease is AFF2 (AF4/FMR2 Family Member 2). The drugs Doxycycline and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include testes.

Wikipedia : 75 Brill-Zinsser disease is a delayed relapse of epidemic typhus, caused by Rickettsia prowazekii. After a... more...

Related Diseases for Brill-Zinsser Disease

Diseases related to Brill-Zinsser Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 epidemic typhus 12.1
2 typhus-group rickettsiosis 10.6
3 endemic typhus 10.4
4 exanthem 10.4
5 aseptic meningitis 10.4
6 48,xyyy 10.4
7 spotted fever 10.1
8 diabetes insipidus 10.1
9 meningitis 10.1

Graphical network of the top 20 diseases related to Brill-Zinsser Disease:



Diseases related to Brill-Zinsser Disease

Symptoms & Phenotypes for Brill-Zinsser Disease

Drugs & Therapeutics for Brill-Zinsser Disease

Drugs for Brill-Zinsser Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2
Azithromycin Approved Phase 4 83905-01-5 447043 55185
3 Anti-Bacterial Agents Phase 4
4 Anti-Infective Agents Phase 4
5 Antibiotics, Antitubercular Phase 4
6 Antitubercular Agents Phase 4
7 Antimalarials Phase 4
8 Antiparasitic Agents Phase 4
9 Antiprotozoal Agents Phase 4
10
Telithromycin Approved Phase 3 191114-48-4 5462516 70789201
11
Rifampicin Approved 13292-46-1 5381226 5458213
12
Ethanol Approved 64-17-5 702
13 Cytochrome P-450 CYP3A Inducers
14 Cytochrome P-450 Enzyme Inducers
15 Nucleic Acid Synthesis Inhibitors
16 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Scrub Typhus Antibiotic Resistance Trial (START) Comparing Doxycycline and Azithromycin Treatment Modalities in Areas of Reported Antimicrobial Resistance for Scrub Typhus Recruiting NCT03083197 Phase 4 Doxycycline 7 days;Doxycycline 3 days;Azithromycin 3 days
2 Phase 3 Study of Controlled Trial: 5-day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00351182 Phase 3 Telithromycin;Doxycycline
3 Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00568711 doxycycline;rifampin
4 The Natural Immune Response In Pediatric Scrub Typhus In Chiangrai Completed NCT02398162
5 Prediction and Early Diagnosis for Cardiovascular Disease Complicated by Scrub Typhus Infection Recruiting NCT03274869
6 Eschar Investigations to Improve Diagnostics, Understand Early Immune Responses and Characterize Strains for Vaccines in Scrub Typhus Recruiting NCT02915861
7 The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents Active, not recruiting NCT02876367
8 A Multicentre Observational Study to Describe the Prevalence of Scrub Typhus Defined as a Positive Rapid Diagnostic Test Among Selected Patients Presenting With Fever to Clinics in Myanmar Active, not recruiting NCT03269266

Search NIH Clinical Center for Brill-Zinsser Disease

Cochrane evidence based reviews: typhus, epidemic louse-borne

Genetic Tests for Brill-Zinsser Disease

Anatomical Context for Brill-Zinsser Disease

MalaCards organs/tissues related to Brill-Zinsser Disease:

41
Testes

Publications for Brill-Zinsser Disease

Articles related to Brill-Zinsser Disease:

(show top 50) (show all 51)
# Title Authors PMID Year
1
Rickettsiae and rickettsial diseases in Croatia: Implications for travel medicine. 38
27404664 2016
2
Brill-Zinsser disease in Moroccan man, France, 2011. 38
22261378 2012
3
Plant extracts, isolated phytochemicals, and plant-derived agents which are lethal to arthropod vectors of human tropical diseases--a review. 38
21432748 2011
4
Brill-Zinsser disease in a patient following infection with sylvatic epidemic typhus associated with flying squirrels. 38
20687836 2010
5
Adipose tissue serves as a reservoir for recrudescent Rickettsia prowazekii infection in a mouse model. 38
20049326 2010
6
Epidemic typhus. 38
18582834 2008
7
[Sanitary conditions, health care and epidemiological situation of infectious diseases in Cracow in the period of Galicia autonomy (since 60ties/70ties of 19th century until 1914)]. 38
18536242 2008
8
Rickettsial diseases in Russia. 38
17114680 2006
9
Eradication of typhus exanthematicus in Bosnia and Herzegovina. 38
16533184 2006
10
Epidemiological characteristics of rickettsial diseases in Croatia. 38
16532877 2006
11
Seroepidemiology of spotted fever group and typhus group rickettsioses in humans, South Korea. 38
15665449 2005
12
[The Brill-Zinsser disease still occurs in Croatia: retrospective analysis of 25 hospitalized patients]. 38
12619436 2002
13
Brill-Zinsser disease. 38
11323068 2001
14
Failure of azithromycin in treatment of Brill-Zinsser disease. 38
10817744 2000
15
[Brill-Zinsser disease]. 38
11212755 2000
16
Brill-Zinsser disease in France. 38
10371575 1999
17
[Brill-Zinsser disease]. 38
10201198 1999
18
Serological response of patients suffering from primary and recrudescent typhus: comparison of complement fixation reaction, Weil-Felix test, microimmunofluorescence, and immunoblotting. 38
7496969 1994
19
Epidemiology of rickettsial diseases. 38
1884775 1991
20
[The clinical spectrum of rickettsiosis in the area of Zadar]. 38
2398776 1990
21
[An indirect solid-phase immunoenzyme method in diagnosing rickettsial infections]. 38
2485298 1989
22
Brill-Zinsser disease in North America. 38
7347050 1980
23
Serologic diagnosis of epidemic typhus fever. 38
403761 1977
24
[Brill-Zinsser disease in the region of East Slovakia (author's transl)]. 38
858075 1977
25
[An unusual case of the Brill-Zinsser disease (author's transl)]. 38
940412 1976
26
[Data on the use of serological tests for differentiation of exanthematous typhus primary infection from that of recurrences in native cases of Brill-Zinsser disease]. 38
128091 1975
27
Brill-Zinsser disease: report of a case in Canada. 38
4841839 1974
28
[Current results and methods in eradication of typhus fever on the Serbian territory excluding autonomic provinces]. 38
4464479 1974
29
Fluorescent antibody complement fixation test as a serodiagnostic method in the Brill-Zinsser disease. 38
4124598 1972
30
Recrudescent typhus: fluctuations in titers of complement-fixing and microagglutinating antibodies to rickettsia prowazeki in persons with a history of epidemic typhus. 38
25607582 1970
31
[Brill-Zinsser disease--presentation of six patients]. 38
5206665 1970
32
Incidence of Brill-Zinsser disease in East Slovakia in 1956-1967. 38
4992900 1970
33
[Brill Zinsser disease. (Clinical analysis of our cases)]. 38
5954659 1966
34
[Contributions to the study of serological diagnosis methods in rickettsioses. I. Microagglutination of rickettsia in the diagnosis of relapsing typhus (Brill-Zinsser disease)]. 38
5967206 1966
35
[Contribution to the study of serological diagnostic methods in rickettsioses. II. Passive hemagglutination in the diagnosis of relapsing typhus (Brill-Zinsser disease)]. 38
5967207 1966
36
The natural history of recrudescent typhus (Brill-Zinsser disease) in Bosnia. 38
5296997 1966
37
SEROLOGIC STUDIES OF PRIMARY EPIDEMIC TYPHUS AND RECRUDESCENT TYPHUS (BRILL-ZINSSER DISEASE). I. DIFFERENCES IN COMPLEMENT-FIXING ANTIBODIES: HIGH ANTIGEN REQUIREMENT AND HEAT LABILITY. 38
14296293 1965
38
SEROLOGIC STUDIES OF PRIMARY EPIDEMIC TYPHUS AND RECRUDESCENT TYPHUS (BRILL-ZINSSER DISEASE). II. DIFFERENCES IN IMMUNOELECTROPHORETIC PATTERNS, RESPONSE TO 2-MERCAPTOETHANOL AND RELATIONSHIPS TO 19 S AND 7 S ANTIBODIES. 38
14296294 1965
39
DIFFERENTIATION OF 19S AND 7S COMPLEMENT FIXING ANTIBODIES IN PRIMARY VERSUS RECRUDESCENT TYPHUS BY EITHER ETHANETHIOL OR HEAT. 38
14297874 1965
40
[Brill-Zinsser disease]. 38
13968310 1963
41
[On the problem of Brill-Zinsser disease (with a case report)]. 38
13890149 1961
42
[Contribution to clinical aspects and diagnosis of Brill-Zinsser disease]. 38
13721745 1961
43
[Contribution to the epidemiological role of Brill-Zinsser disease in the area of endemic typhus. A focus of disease produced by a patient in the recurrent stage (morbus Brill-Zinsser)]. 38
13817644 1959
44
[A rare clinical form of Brill-Zinsser disease]. 38
13837267 1959
45
BRILL-ZINSSER disease. 38
13612156 1958
46
Brill-Zinsser disease; the possibility of its occurrence in Britain. 38
13587985 1958
47
[Brill-Zinsser disease in the Kosice region]. 38
13537009 1958
48
Another case of Brill-Zinsser disease in Britain. 38
13347109 1956
49
Recrudescent typhus (Brill's disease). 38
13260998 1955
50
[Recurrent typhus; Brill-Zinsser disease; incidence, epidemiology and clinical aspects in our country]. 38
13347647 1955

Variations for Brill-Zinsser Disease

Expression for Brill-Zinsser Disease

Search GEO for disease gene expression data for Brill-Zinsser Disease.

Pathways for Brill-Zinsser Disease

GO Terms for Brill-Zinsser Disease

Sources for Brill-Zinsser Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....