MCID: BRL001
MIFTS: 25

Brill-Zinsser Disease

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Brill-Zinsser Disease

MalaCards integrated aliases for Brill-Zinsser Disease:

Name: Brill-Zinsser Disease 12 60 15 17 74
Recrudescent Typhus 12 60
Typhus, Epidemic Louse-Borne 45
Brill Zinsser Disease 12
Brill's Disease 12
Sporadic Typhus 12
Latent Typhus 12
Brill Disease 60

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11254
ICD9CM 36 081.1
MeSH 45 D014438
SNOMED-CT 69 47761007
ICD10 34 A75.1
ICD10 via Orphanet 35 A75.1
UMLS via Orphanet 75 C0006181
Orphanet 60 ORPHA99990
UMLS 74 C0006181

Summaries for Brill-Zinsser Disease

Disease Ontology : 12 An epidemic typhus that is a mild form of the disease, which recurs in someone after a long period of latency due to immunosuppression, malnutrition or other illnesses.

MalaCards based summary : Brill-Zinsser Disease, also known as recrudescent typhus, is related to epidemic typhus and diabetes insipidus. An important gene associated with Brill-Zinsser Disease is AFF2 (AF4/FMR2 Family Member 2). The drugs Doxycycline and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include testes.

Wikipedia : 77 Brill–Zinser disease is a delayed relapse of epidemic typhus, caused by Rickettsia prowazekii. After a... more...

Related Diseases for Brill-Zinsser Disease

Diseases related to Brill-Zinsser Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 epidemic typhus 12.0
2 diabetes insipidus 10.1

Symptoms & Phenotypes for Brill-Zinsser Disease

Drugs & Therapeutics for Brill-Zinsser Disease

Drugs for Brill-Zinsser Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 564-25-0 54671203
2
Azithromycin Approved Phase 4 83905-01-5 447043 55185
3 Antitubercular Agents Phase 4,Not Applicable
4 Anti-Bacterial Agents Phase 4,Phase 3,Not Applicable
5 Antiprotozoal Agents Phase 4,Phase 3,Not Applicable
6 Antibiotics, Antitubercular Phase 4,Not Applicable
7 Antiparasitic Agents Phase 4,Phase 3,Not Applicable
8 Antimalarials Phase 4,Phase 3,Not Applicable
9 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
10
Telithromycin Approved Phase 3 191114-48-4 70789201 5462516
11
Rifampicin Approved Not Applicable 13292-46-1 5381226 5458213
12
carbamide peroxide Approved 124-43-6
13
Ethanol Approved 64-17-5 702
14 Cytochrome P-450 CYP3A Inducers Not Applicable
15 Nucleic Acid Synthesis Inhibitors Not Applicable
16 Vaccines
17 Immunoglobulins
18 Antibodies
19 Immunoglobulin M
20 Immunoglobulin A
21 Immunoglobulin G

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Scrub Typhus Antibiotic Resistance Trial Recruiting NCT03083197 Phase 4 Doxycycline 7 days;Doxycycline 3 days;Azithromycin 3 days
2 Controlled Trial: 5-day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00351182 Phase 3 Telithromycin;Doxycycline
3 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
4 Scrub Typhus Pediatric Immunology Study Completed NCT02398162
5 Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Completed NCT00568711 Not Applicable doxycycline;rifampin
6 Causes of Fever in Bangladeshi Patients Completed NCT02339259
7 Type 2 Diabetes Mellitus: New Approaches to Optimize Medical Care in General Practice Completed NCT00742547 Not Applicable
8 The Impact of C-reactive Protein Testing Completed NCT02758821 Not Applicable
9 Scrub Typhus Infection Induced Cardiovascular Disease Recruiting NCT03274869
10 Eschar Investigations in Scrub Typhus Recruiting NCT02915861
11 Scrub Typhus RDT Study Active, not recruiting NCT03269266
12 The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents Active, not recruiting NCT02876367
13 Rickettsiae in Myanmar Not yet recruiting NCT03847870
14 Lyme Test Indication Combinations (LyTIC) Study Terminated NCT03201042

Search NIH Clinical Center for Brill-Zinsser Disease

Cochrane evidence based reviews: typhus, epidemic louse-borne

Genetic Tests for Brill-Zinsser Disease

Anatomical Context for Brill-Zinsser Disease

MalaCards organs/tissues related to Brill-Zinsser Disease:

42
Testes

Publications for Brill-Zinsser Disease

Articles related to Brill-Zinsser Disease:

(show all 20)
# Title Authors Year
1
Brill-Zinsser disease in Moroccan man, France, 2011. ( 22261378 )
2012
2
Brill-Zinsser disease in a patient following infection with sylvatic epidemic typhus associated with flying squirrels. ( 20687836 )
2010
3
Brill-Zinsser disease. ( 11323068 )
2001
4
Failure of azithromycin in treatment of Brill-Zinsser disease. ( 10817744 )
2000
5
Brill-Zinsser disease in France. ( 10371575 )
1999
6
Serological response of patients suffering from primary and recrudescent typhus: comparison of complement fixation reaction, Weil-Felix test, microimmunofluorescence, and immunoblotting. ( 7496969 )
1994
7
Brill-Zinsser disease in North America. ( 7347050 )
1980
8
Brill-Zinsser disease: report of a case in Canada. ( 4841839 )
1974
9
Fluorescent antibody complement fixation test as a serodiagnostic method in the Brill-Zinsser disease. ( 4124598 )
1972
10
Recrudescent typhus: fluctuations in titers of complement-fixing and microagglutinating antibodies to rickettsia prowazeki in persons with a history of epidemic typhus. ( 25607582 )
1970
11
Incidence of Brill-Zinsser disease in East Slovakia in 1956-1967. ( 4992900 )
1970
12
The natural history of recrudescent typhus (Brill-Zinsser disease) in Bosnia. ( 5296997 )
1966
13
SEROLOGIC STUDIES OF PRIMARY EPIDEMIC TYPHUS AND RECRUDESCENT TYPHUS (BRILL-ZINSSER DISEASE). II. DIFFERENCES IN IMMUNOELECTROPHORETIC PATTERNS, RESPONSE TO 2-MERCAPTOETHANOL AND RELATIONSHIPS TO 19 S AND 7 S ANTIBODIES. ( 14296294 )
1965
14
SEROLOGIC STUDIES OF PRIMARY EPIDEMIC TYPHUS AND RECRUDESCENT TYPHUS (BRILL-ZINSSER DISEASE). I. DIFFERENCES IN COMPLEMENT-FIXING ANTIBODIES: HIGH ANTIGEN REQUIREMENT AND HEAT LABILITY. ( 14296293 )
1965
15
DIFFERENTIATION OF 19S AND 7S COMPLEMENT FIXING ANTIBODIES IN PRIMARY VERSUS RECRUDESCENT TYPHUS BY EITHER ETHANETHIOL OR HEAT. ( 14297874 )
1965
16
BRILL-ZINSSER disease. ( 13612156 )
1958
17
Brill-Zinsser disease; the possibility of its occurrence in Britain. ( 13587985 )
1958
18
Another case of Brill-Zinsser disease in Britain. ( 13347109 )
1956
19
Recrudescent typhus (Brill's disease). ( 13260998 )
1955
20
Brill-Zinsser disease. ( 13295773 )
1955

Variations for Brill-Zinsser Disease

Expression for Brill-Zinsser Disease

Search GEO for disease gene expression data for Brill-Zinsser Disease.

Pathways for Brill-Zinsser Disease

GO Terms for Brill-Zinsser Disease

Sources for Brill-Zinsser Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....