MCID: BRL001
MIFTS: 17

Brill-Zinsser Disease

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Brill-Zinsser Disease

MalaCards integrated aliases for Brill-Zinsser Disease:

Name: Brill-Zinsser Disease 12 59 15 73
Recrudescent Typhus 12 59
Typhus, Epidemic Louse-Borne 44
Brill Zinsser Disease 12
Brill's Disease 12
Sporadic Typhus 12
Latent Typhus 12
Brill Disease 59

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11254
ICD10 33 A75.1
ICD9CM 35 081.1
MeSH 44 D014438
SNOMED-CT 68 47761007
Orphanet 59 ORPHA99990
ICD10 via Orphanet 34 A75.1
UMLS via Orphanet 74 C0006181
UMLS 73 C0006181

Summaries for Brill-Zinsser Disease

Disease Ontology : 12 An epidemic typhus that is a mild form of the disease, which recurs in someone after a long period of latency due to immunosuppression, malnutrition or other illnesses.

MalaCards based summary : Brill-Zinsser Disease, also known as recrudescent typhus, is related to epidemic typhus. An important gene associated with Brill-Zinsser Disease is AFF2 (AF4/FMR2 Family Member 2). The drugs Doxycycline and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include testes.

Related Diseases for Brill-Zinsser Disease

Diseases related to Brill-Zinsser Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 epidemic typhus 12.0

Symptoms & Phenotypes for Brill-Zinsser Disease

Drugs & Therapeutics for Brill-Zinsser Disease

Drugs for Brill-Zinsser Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 564-25-0 54671203
2
Azithromycin Approved Phase 4 83905-01-5 55185 447043
3 Antibiotics, Antitubercular Phase 4,Not Applicable
4 Antimalarials Phase 4,Phase 3,Not Applicable
5 Antitubercular Agents Phase 4,Not Applicable
6 Anti-Bacterial Agents Phase 4,Phase 3,Not Applicable
7 Antiparasitic Agents Phase 4,Phase 3,Not Applicable
8 Antiprotozoal Agents Phase 4,Phase 3,Not Applicable
9 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
10
Telithromycin Approved Phase 3 191114-48-4 0 5462516
11
Rifampicin Approved Not Applicable 13292-46-1 5458213 5381226
12
Ethanol Approved 64-17-5 702
13 Nucleic Acid Synthesis Inhibitors Not Applicable
14 Cytochrome P-450 CYP3A Inducers Not Applicable
15 Vaccines
16 Immunoglobulins
17 Immunoglobulin A
18 Antibodies
19 Immunoglobulin G
20 Immunoglobulin M

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Scrub Typhus Antibiotic Resistance Trial Recruiting NCT03083197 Phase 4 Doxycycline 7 days;Doxycycline 3 days;Azithromycin 3 days
2 Controlled Trial: 5-Day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00351182 Phase 3 Telithromycin;Doxycycline
3 Controlled Trial: 5-Day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00568711 Not Applicable doxycycline;rifampin
4 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
5 Scrub Typhus Pediatric Immunology Study Completed NCT02398162
6 Causes of Fever in Bangladeshi Patients Completed NCT02339259
7 Type 2 Diabetes Mellitus: New Approaches to Optimize Medical Care in General Practice Completed NCT00742547 Not Applicable
8 The Impact of C-reactive Protein Testing Completed NCT02758821 Not Applicable
9 Scrub Typhus Infection Induced Cardiovascular Disease Recruiting NCT03274869
10 Eschar Investigations in Scrub Typhus Recruiting NCT02915861
11 Scrub Typhus RDT Study Active, not recruiting NCT03269266
12 The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents Active, not recruiting NCT02876367
13 Lyme Test Indication Combinations (LyTIC) Study Terminated NCT03201042

Search NIH Clinical Center for Brill-Zinsser Disease

Cochrane evidence based reviews: typhus, epidemic louse-borne

Genetic Tests for Brill-Zinsser Disease

Anatomical Context for Brill-Zinsser Disease

MalaCards organs/tissues related to Brill-Zinsser Disease:

41
Testes

Publications for Brill-Zinsser Disease

Articles related to Brill-Zinsser Disease:

(show all 20)
# Title Authors Year
1
Brill-Zinsser disease in Moroccan man, France, 2011. ( 22261378 )
2012
2
Brill-Zinsser disease in a patient following infection with sylvatic epidemic typhus associated with flying squirrels. ( 20687836 )
2010
3
Brill-Zinsser disease. ( 11323068 )
2001
4
Failure of azithromycin in treatment of Brill-Zinsser disease. ( 10817744 )
2000
5
Brill-Zinsser disease in France. ( 10371575 )
1999
6
Serological response of patients suffering from primary and recrudescent typhus: comparison of complement fixation reaction, Weil-Felix test, microimmunofluorescence, and immunoblotting. ( 7496969 )
1994
7
Brill-Zinsser disease in North America. ( 7347050 )
1980
8
Brill-Zinsser disease: report of a case in Canada. ( 4841839 )
1974
9
Fluorescent antibody complement fixation test as a serodiagnostic method in the Brill-Zinsser disease. ( 4124598 )
1972
10
Incidence of Brill-Zinsser disease in East Slovakia in 1956-1967. ( 4992900 )
1970
11
Recrudescent typhus: fluctuations in titers of complement-fixing and microagglutinating antibodies to rickettsia prowazeki in persons with a history of epidemic typhus. ( 25607582 )
1970
12
The natural history of recrudescent typhus (Brill-Zinsser disease) in Bosnia. ( 5296997 )
1966
13
SEROLOGIC STUDIES OF PRIMARY EPIDEMIC TYPHUS AND RECRUDESCENT TYPHUS (BRILL-ZINSSER DISEASE). I. DIFFERENCES IN COMPLEMENT-FIXING ANTIBODIES: HIGH ANTIGEN REQUIREMENT AND HEAT LABILITY. ( 14296293 )
1965
14
SEROLOGIC STUDIES OF PRIMARY EPIDEMIC TYPHUS AND RECRUDESCENT TYPHUS (BRILL-ZINSSER DISEASE). II. DIFFERENCES IN IMMUNOELECTROPHORETIC PATTERNS, RESPONSE TO 2-MERCAPTOETHANOL AND RELATIONSHIPS TO 19 S AND 7 S ANTIBODIES. ( 14296294 )
1965
15
DIFFERENTIATION OF 19S AND 7S COMPLEMENT FIXING ANTIBODIES IN PRIMARY VERSUS RECRUDESCENT TYPHUS BY EITHER ETHANETHIOL OR HEAT. ( 14297874 )
1965
16
Brill-Zinsser disease; the possibility of its occurrence in Britain. ( 13587985 )
1958
17
BRILL-ZINSSER disease. ( 13612156 )
1958
18
Another case of Brill-Zinsser disease in Britain. ( 13347109 )
1956
19
Brill-Zinsser disease. ( 13295773 )
1955
20
Recrudescent typhus (Brill's disease). ( 13260998 )
1955

Variations for Brill-Zinsser Disease

Expression for Brill-Zinsser Disease

Search GEO for disease gene expression data for Brill-Zinsser Disease.

Pathways for Brill-Zinsser Disease

GO Terms for Brill-Zinsser Disease

Sources for Brill-Zinsser Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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