MCID: BRT037
MIFTS: 25

Brittle Diabetes

Categories: Rare diseases

Aliases & Classifications for Brittle Diabetes

MalaCards integrated aliases for Brittle Diabetes:

Name: Brittle Diabetes 52 54 71
Brittle Type 1 Diabetes Mellitus 71
Brittle Diabetes Mellitus 52
Brittle Type 1 Diabetes 52
Labile Diabetes 52

Classifications:



External Ids:

UMLS 71 C0342302 C0567407

Summaries for Brittle Diabetes

NIH Rare Diseases : 52 Brittle diabetes is a term that is sometimes used to describe hard-to-control diabetes (also called labile diabetes) . It is characterized by wide variations or "swings" in blood glucose (sugar) in which blood glucose levels can quickly move from too high ( hyperglycemia ) to too low ( hypoglycemia ). These episodes are hard to predict and can disrupt quality of life. They can require frequent or lengthy hospitalizations and can be fatal. People with type 1 diabetes are at greatest risk . While many people with type 1 diabetes experience hypoglycemia, only a small proportion of people with type 1 diabetes experience the frequent blood glucose swings described as "brittle." People with long-standing type 2 diabetes may also have difficulty controlling blood glucose, but few have these frequent swings. People of any age with diabetes can be affected with these frequent ups and downs in blood glucose levels. Some research suggests that women may be affected more often than men. Frequent episodes of hypoglycemia can lead to hypoglycemic unawareness and make the condition worse. Keeping diabetes under good control for at least several weeks can restore hypoglycemic awareness. New technologies such as continuous glucose monitors and insulin pumps may help improve control. In diabetes, many factors can trigger frequent changes in blood glucose levels. For example, people who don't test blood glucose or take diabetes medications as prescribed often experience significant fluctuations in blood glucose levels. Other causes of unstable blood glucose levels include emotional stress, eating disorders, drug or alcohol use, malabsorption , gastroparesis , and celiac disease . The development of new treatments for diabetes has made it easier for most people to control their blood glucose levels. Artificial pancreas technology is currently being tested in clinical trials and aims to help people with type 1 diabetes more easily manage blood glucose levels. In 2016, the U.S. Food and Drug Administration approved a hybrid model of an artificial pancreas, an automated system that requires users to adjust insulin intake at mealtimes. NIH-funded research on islet cell transplantation has also shown promising results in restoring blood glucose control. This research specifically includes people who have experienced episodes of severe hypoglycemia.

MalaCards based summary : Brittle Diabetes, also known as brittle type 1 diabetes mellitus, is related to diabetes mellitus and hypoglycemia. An important gene associated with Brittle Diabetes is INS (Insulin). The drugs Abatacept and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include pancreas, testes and kidney.

Related Diseases for Brittle Diabetes

Graphical network of the top 20 diseases related to Brittle Diabetes:



Diseases related to Brittle Diabetes

Symptoms & Phenotypes for Brittle Diabetes

Drugs & Therapeutics for Brittle Diabetes

Drugs for Brittle Diabetes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abatacept Approved Phase 4 332348-12-6 10237
2
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
3 Immunologic Factors Phase 4
4 Antirheumatic Agents Phase 4
5 Calcineurin Inhibitors Phase 4
6
Zinc Approved, Investigational Phase 3 7440-66-6 32051
7
Insulin aspart Approved Phase 3 116094-23-6 16132418
8 Insulin, Globin Zinc Phase 3
9 insulin Phase 3
10 Hypoglycemic Agents Phase 3
11
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
12
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
13
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177 70789204
14
Methylprednisolone hemisuccinate Approved Phase 1, Phase 2 2921-57-5
15 Prednisolone acetate Approved, Vet_approved Phase 1, Phase 2 52-21-1
16
Prednisolone phosphate Approved, Vet_approved Phase 1, Phase 2 302-25-0
17
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
18
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
19
Prednisone Approved, Vet_approved Phase 1, Phase 2 53-03-2 5865
20
Prednisolone hemisuccinate Experimental Phase 1, Phase 2 2920-86-7
21 Thymoglobulin Phase 1, Phase 2
22 Methylprednisolone Acetate Phase 1, Phase 2
23 Antibodies, Monoclonal Phase 2
24 Antibodies Phase 2
25 Immunoglobulins Phase 2
26 Liver Extracts Phase 2
27 Hormone Antagonists Phase 1, Phase 2
28 Hormones Phase 1, Phase 2
29 Gastrins Phase 1, Phase 2
30
Pancrelipase Approved, Investigational 53608-75-6
31 Gastrointestinal Agents
32 pancreatin
33 Immunosuppressive Agents
34 Hematinics

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Calcineurin Inhibitors to Belatacept Switch Study to Prevent the Progression of Kidney Disease in Pancreas Transplant Alone Recipients Completed NCT02103855 Phase 4 Belatacept
2 Health Economic Analysis of Islet Cell Transplantation for Patients With Severe Forms of Brittle Type 1 Diabetes Recruiting NCT02854696 Phase 3 best medical care
3 Effects of Pulsatile Intravenous Insulin on Brittle Diabetes and Glucose Control Terminated NCT01029444 Phase 3
4 Effects on Diabetic Metabolic Integrity With Treatment of Pulsatile Intravenous Insulin Therapy as Evidenced by Monitoring of Diabetic Complications. Terminated NCT00539409 Phase 2, Phase 3
5 Transplantation d'Ilots Pancreatiques Allogeniques Adultes Pour le Traitement du Diabete Insulino-dependant: Etude GRAGIL 2. Completed NCT00321256 Phase 1, Phase 2
6 A Multi-step Trial Towards Single Donor Islet Transplantation in Type 1 Diabetic Patients, Using Calcineurin Inhibitor-free Immunosuppression Completed NCT01346085 Phase 1, Phase 2 CNI free immunosuppression
7 Development of Immunosuppression Regimens to Facilitate Single Donor Islet Transplantation Using Abatacept Completed NCT00276250 Phase 2 Efalizumab;Abatacept;Belatacept
8 Islet Transplantation in Type 1 Diabetes Using the Edmonton Protocol of Steroid Free Immunosuppression Completed NCT00133809 Phase 2 Transplantation of Human Islets
9 Islet Transplantation Using a T-Cell Depleting Immunosuppression Induction Regimen Recruiting NCT01909245 Phase 2
10 Improving Islet Transplantation Outcomes With Gastrin Recruiting NCT03746769 Phase 1, Phase 2 Gastrin 17
11 UVA Islet Cell Transplantation in Patients With Type I Diabetes Unknown status NCT00605592 Phase 1
12 Regeneration of Insulin Production in Patients With Type 1 Diabetes by Autologous Bone Marrow Blood Infusion Completed NCT00821899
13 Nephrologic Prognosis 10 Years After Diabetes Cell Therapy Recruiting NCT02627690
14 Human Alloislet Transplant for Type 1 or Surgical Diabetes Mellitus With Complications Available NCT01606475
15 A Prospective, Observational Study in Pancreatic Allograft Recipients: The Effect of Risk Factors, Immunosuppressive Level and the Benefits of Scheduled Biopsies - on Surgical Complications, Rejections and Graft Survival Enrolling by invitation NCT01957696
16 Collection of Human Liver Biopsy and Whole Blood Samples From Type 1 Diabetes Mellitus (T1DM), Total or Partial Pancreatectomy Patients for Potential Use as an Autologous Source for Insulin Producing Cells in Future Clinical Studies Not yet recruiting NCT04038931

Search NIH Clinical Center for Brittle Diabetes

Genetic Tests for Brittle Diabetes

Anatomical Context for Brittle Diabetes

MalaCards organs/tissues related to Brittle Diabetes:

40
Pancreas, Testes, Kidney, Liver, Bone, T Cells, Bone Marrow

Publications for Brittle Diabetes

Articles related to Brittle Diabetes:

(show top 50) (show all 301)
# Title Authors PMID Year
1
[Does brittle diabetes exist as a clinical entity?]. 54 61
19649386 2009
2
Prospects for future advancements in islet cell transplantation. 54 61
19202536 2009
3
A case of hypoglycemic brittle diabetes with peripheral edema successfully managed by conversion from insulin lispro to insulin aspart. 54 61
18676048 2008
4
Over 500 solitary pancreas transplants in nonuremic patients with brittle diabetes mellitus. 54 61
18192910 2008
5
A case of slowly progressive type 1 diabetes with unstable glycemic control caused by unusual insulin antibody and successfully treated with steroid therapy. 54 61
16439034 2006
6
Usefulness of measuring the gastric emptying time in a case of brittle diabetes. 54 61
15515755 2004
7
Diagnostic algorithm and management of immune-mediated complications associated with subcutaneous insulin therapy. 54 61
15372360 2004
8
Islet allotransplantation in type 1 diabetic patients. 54 61
12717341 2003
9
[Recent trends of development of rapid-acting and long-acting human insulin analogues--its biological characteristics and clinical availability]. 54 61
11712396 2001
10
Brittle diabetes in the elderly. 54 61
11691895 2001
11
[Psychosocial predictors of metabolic instability in brittle diabetes--a multivariate time series analysis]. 54 61
11447656 2001
12
[Pancreas transplantation: who and when?]. 54 61
11374222 2001
13
[Clinical study of the month. Prolonged insulin independence after transplantation of islets of Langerhans in a patient with type 1 diabetes: achievement of a dream?]. 54 61
11051779 2000
14
Adherence to insulin treatment, glycaemic control, and ketoacidosis in insulin-dependent diabetes mellitus. The DARTS/MEMO Collaboration. Diabetes Audit and Research in Tayside Scotland. Medicines Monitoring Unit. 54 61
9388398 1997
15
A treatable cause of recurrent severe hypoglycemia. 54 61
7924785 1994
16
Successful treatment of unusual case of brittle diabetes with sulfated beef insulin. 54 61
1797500 1991
17
Management of "brittle" diabetes with a preprogrammable implanted insulin pump delivering intraperitoneal insulin. 54 61
2252927 1990
18
The 36% coefficient of variation for glucose proposed for separating stable and labile diabetes is clinically relevant: A continuous glucose monitoring-based study in a large population of type 1 diabetes patients. 61
29910090 2019
19
Outcome and long-term quality of life after total pancreatectomy (PANORAMA): a nationwide cohort study. 61
31500907 2019
20
Pancreas transplantation following total pancreatectomy for chronic pancreatitis. 61
31627258 2019
21
Real-Time, Intraoperative Doppler/Ultrasound Monitoring of Islet Infusion During Total Pancreatectomy With Islet Autotransplant: A First Report. 61
31669073 2019
22
Systematic review of functional outcome and quality of life after total pancreatectomy. 61
31502658 2019
23
Recurrent diabetic ketoacidosis and a brief history of brittle diabetes research: contemporary and past evidence in diabetic ketoacidosis research including mortality, mental health and prevention. 61
31418474 2019
24
Advances in β-cell replacement therapy for the treatment of type 1 diabetes. 61
31533905 2019
25
Islet Autotransplantation in Diabetic Patients. 61
31439326 2019
26
Efficacy and safety of islet autotransplantation after total pancreatectomy in chronic pancreatitis: A systematic review and meta-analysis including 17 studies. 61
31523018 2019
27
The hypoglycemia associated autonomic failure triggered by exercise in the patients with "brittle" diabetes and the strategy for prevention. 61
31406090 2019
28
Indications for islet or pancreatic transplantation: Statement of the TREPID working group on behalf of the Société francophone du diabète (SFD), Société francaise d'endocrinologie (SFE), Société francophone de transplantation (SFT) and Société française de néphrologie - dialyse - transplantation (SFNDT). 61
30223084 2019
29
Alexithymia in adults with brittle type 1 diabetes. 61
31125008 2019
30
Brittle diabetes revisited: a description of erratic and difficult-to-control diabetes in an elderly woman with Type 1 diabetes. 61
31004371 2019
31
Diabetes of the exocrine pancreas. 61
30151918 2019
32
Hepatomegaly and type 1 diabetes: a clinical case of Mauriac's syndrome. 61
30616577 2019
33
Effects of sodium-glucose cotransporter 2 inhibitors on hypoglycaemia in brittle diabetic patients with decreased endogenous insulin secretion. 61
30815573 2019
34
Solid pancreas transplant: Pushing forward. 61
30596031 2018
35
Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells. 61
29781950 2018
36
Incidental Neuroendocrine Tumor Discovered After Total Pancreatectomy Intended for Islet Autotransplantation: Important Considerations for Surgical Decision-Making. 61
29894419 2018
37
Islets Allotransplantation Into Gastric Submucosa in a Patient with Portal Hypertension: 4-year Follow-up. 61
30056927 2018
38
Use of an Insulin Pump in the Elderly Surgical Patient: Tolerance of Total Pancreatectomy After Neoadjuvant Chemotherapy for Multifocal Pancreatic Cancer. 61
30788460 2018
39
Perioperative management of endocrine insufficiency after total pancreatectomy for neoplasia. 61
28733926 2017
40
Autologous islet transplantation: challenges and lessons. 61
28562418 2017
41
Simultaneous Pancreas and Kidney Transplantation-Is It a Treatment Option for Patients With Type 2 Diabetes Mellitus? An Analysis of the International Pancreas Transplant Registry. 61
28478590 2017
42
Clinical aspects of pancreatogenic diabetes secondary to hereditary pancreatitis. 61
28101143 2017
43
Brittle diabetes: Psychopathology and personality. 61
27524279 2016
44
NOCTURNAL HYPOGLYCEMIA--THE MAIN INDICATION FOR INSULIN PUMP THERAPY IN ADULTHOOD. 61
27333724 2016
45
Pancreatic islet autotransplantation for nonmalignant and malignant indications. 61
26593636 2016
46
Use of cross-reactivity immunoassay to orient insulin replacement in diabetic patients with high levels of insulin antibodies. 61
27617231 2016
47
New Methods in Exploring Old Topics: Case Studying Brittle Diabetes in the Family Context. 61
26634215 2016
48
Sweet and brittle - Diabetes mellitus and the skeleton. 61
26363338 2016
49
[Total pancreatectomy for pancreatic malignancy - from history to the present day]. 61
27879138 2016
50
Evolution of Islet Transplantation for the Last 30 Years. 61
26658037 2016

Variations for Brittle Diabetes

Expression for Brittle Diabetes

Search GEO for disease gene expression data for Brittle Diabetes.

Pathways for Brittle Diabetes

GO Terms for Brittle Diabetes

Sources for Brittle Diabetes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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