MCID: BRT037
MIFTS: 24

Brittle Diabetes

Categories: Rare diseases

Aliases & Classifications for Brittle Diabetes

MalaCards integrated aliases for Brittle Diabetes:

Name: Brittle Diabetes 54 56 74
Brittle Type 1 Diabetes Mellitus 74
Brittle Diabetes Mellitus 54
Brittle Type 1 Diabetes 54
Labile Diabetes 54

Classifications:



External Ids:

Summaries for Brittle Diabetes

NIH Rare Diseases : 54 Brittle diabetes is a term that is sometimes used to describe hard-to-control diabetes (also called labile diabetes). It is characterized by wide variations or �??swings�?� in blood glucose (sugar) in which blood glucose levels can quickly move from too high (hyperglycemia) to too low (hypoglycemia). These episodes are hard to predict and can disrupt quality of life. They can require frequent or lengthy hospitalizations and can be fatal. People with type 1 diabetes are at greatest risk. While many people with type 1 diabetes experience hypoglycemia, only a small proportion of people with type 1 diabetes experience the frequent blood glucose swings described as �??brittle.�?� People with long-standing type 2 diabetes may also have difficulty controlling blood glucose, but few have these frequent swings. People of any age with diabetes can be affected with these frequent ups and downs in blood glucose levels. Some research suggests that women may be affected more often than men.Frequent episodes of hypoglycemia can lead to hypoglycemic unawareness and make the condition worse.  Keeping diabetes under good control for at least several weeks can restore hypoglycemic awareness.  New technologies such as continuous glucose monitors and insulin pumps may help improve control.In diabetes, many factors can trigger frequent changes in blood glucose levels. For example, people who don�??t test blood glucose or take diabetes medications as prescribed often experience significant fluctuations in blood glucose levels. Other causes of unstable blood glucose levels include emotional stress, eating disorders, drug or alcohol use, malabsorption, gastroparesis, and celiac disease.   The development of new treatments for diabetes has made it easier for most people to control their blood glucose levels. Artificial pancreas technology is currently being tested in clinical trials and aims to help people with type 1 diabetes more easily manage blood glucose levels. In 2016, the U.S. Food and Drug Administration approved a hybrid model of an artificial pancreas, an automated system that requires users to adjust insulin intake at mealtimes. NIH-funded research on islet cell transplantation has also shown promising results in restoring blood glucose control. This research specifically includes people who have experienced episodes of severe hypoglycemia.

MalaCards based summary : Brittle Diabetes, also known as brittle type 1 diabetes mellitus, is related to diabetes mellitus and diabetes mellitus, noninsulin-dependent. An important gene associated with Brittle Diabetes is INS (Insulin). The drugs Zinc and Insulin Aspart have been mentioned in the context of this disorder. Affiliated tissues include pancreas, testes and bone.

Related Diseases for Brittle Diabetes

Diseases related to Brittle Diabetes via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 diabetes mellitus 10.4
2 diabetes mellitus, noninsulin-dependent 10.1
3 hyperglycemia 10.1
4 hypoglycemia 10.1
5 graves' disease 10.1
6 graves disease 1 10.0
7 hirata disease 10.0

Graphical network of the top 20 diseases related to Brittle Diabetes:



Diseases related to Brittle Diabetes

Symptoms & Phenotypes for Brittle Diabetes

Drugs & Therapeutics for Brittle Diabetes

Drugs for Brittle Diabetes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 3,Phase 2 7440-66-6 32051
2
Insulin Aspart Approved Phase 3,Phase 2 116094-23-6 16132418
3 Hypoglycemic Agents Phase 3,Phase 2,Phase 1
4 Insulin, Globin Zinc Phase 3,Phase 2,Not Applicable
5 insulin Phase 3,Phase 2,Not Applicable
6
Prednisone Approved, Vet_approved Phase 1, Phase 2 53-03-2 5865
7
Everolimus Approved Phase 1, Phase 2 159351-69-6 70789204 6442177
8
Mycophenolic acid Approved Phase 1, Phase 2 24280-93-1 446541
9
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 46835353 5284616 6436030
10
Prednisolone phosphate Approved, Vet_approved Phase 1, Phase 2 302-25-0
11
Methylprednisolone hemisuccinate Approved Phase 1, Phase 2 2921-57-5
12
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
13
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
14
Prednisolone hemisuccinate Experimental Phase 1, Phase 2 2920-86-7
15 Methylprednisolone Acetate Phase 1, Phase 2
16 Prednisolone acetate Phase 1, Phase 2
17 Immunologic Factors Phase 1, Phase 2
18 Calcineurin Inhibitors Phase 1, Phase 2
19 Immunosuppressive Agents Phase 1, Phase 2
20 Thymoglobulin Phase 1, Phase 2
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
22 Hormone Antagonists Phase 1, Phase 2
23 Gastrins Phase 1, Phase 2
24 Liver Extracts Phase 1, Phase 2,Phase 2
25 Hormones Phase 1, Phase 2

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Health Economic Analysis of Islet Cell Transplantation for the Stabilization of the Severe Forms of Type 1 Diabetes Recruiting NCT02854696 Phase 3 best medical care
2 Effects of Pulsed Intravenous (IV) Insulin on Brittle and Uncontrolled Diabetes Terminated NCT01029444 Phase 3
3 Effects of Pulsatile Intravenous Insulin Therapy on Metabolic Integrity in Patients With Diabetes Mellitus Terminated NCT00539409 Phase 2, Phase 3
4 Human Islet Transplantation in Brittle Type 1 Diabetes Mellitus. The GRAGIL 2 Study. Completed NCT00321256 Phase 1, Phase 2
5 Calcineurin Inhibitor (CNI)-Free Immunosuppressive Regimen in T1D Patients Receiving Islet Transplantation Completed NCT01346085 Phase 1, Phase 2 CNI free immunosuppression
6 Effectiveness of Oral Insulin in Unstable Type 1 Diabetes Patients Completed NCT00867594 Phase 2 ORMD 0801
7 Improving Islet Transplantation Outcomes With Gastrin Recruiting NCT03746769 Phase 1, Phase 2 Gastrin 17
8 Islet Cell Transplant for Type 1 Diabetes Recruiting NCT01909245 Phase 2
9 UVA Islet Cell Transplantation in Patients With Type I Diabetes Unknown status NCT00605592 Phase 1
10 Bone Marrow Autotransplantation in Type 1 Diabetes Completed NCT00821899 Not Applicable
11 Nephrologic Prognosis 10 Years After Diabetes Cell Therapy Recruiting NCT02627690
12 Islet Transplant for Type 1 or Surgical Diabetes Available NCT01606475

Search NIH Clinical Center for Brittle Diabetes

Genetic Tests for Brittle Diabetes

Anatomical Context for Brittle Diabetes

MalaCards organs/tissues related to Brittle Diabetes:

42
Pancreas, Testes, Bone, Liver, Bone Marrow

Publications for Brittle Diabetes

Articles related to Brittle Diabetes:

(show top 50) (show all 86)
# Title Authors Year
1
Brittle diabetes revisited: a description of erratic and difficult-to-control diabetes in an elderly woman with Type 1 diabetes. ( 31004371 )
2019
2
Sweet and brittle - Diabetes mellitus and the skeleton. ( 26363338 )
2016
3
New Methods in Exploring Old Topics: Case Studying Brittle Diabetes in the Family Context. ( 26634215 )
2016
4
Brittle diabetes: Psychopathology and personality. ( 27524279 )
2016
5
On the level: is "brittle diabetes" a condition or a consequence of not having the right treatment? ( 24730176 )
2014
6
Brittle diabetes: psychopathological aspects. ( 24897966 )
2014
7
Perioperative glycemic control using an artificial endocrine pancreas in patients undergoing total pancreatectomy: tight glycemic control may be justified in order to avoid brittle diabetes. ( 23442241 )
2013
8
Successful treatment of brittle diabetes following total pancreatectomy by islet allotransplantation: a case report. ( 23846941 )
2013
9
Characterization of insulin antibodies by Surface Plasmon Resonance in two clinical cases: brittle diabetes and insulin autoimmune syndrome. ( 24386337 )
2013
10
Challenges for diabetic care: rural Africa & type 1 brittle diabetes. ( 21680778 )
2011
11
Reversible steatohepatosis in a young boy with brittle type 1 diabetes mellitus: mauriac syndrome. ( 22689598 )
2011
12
[Does brittle diabetes exist as a clinical entity?]. ( 19649386 )
2009
13
Over 500 solitary pancreas transplants in nonuremic patients with brittle diabetes mellitus. ( 18192910 )
2008
14
Dirty electricity elevates blood sugar among electrically sensitive diabetics and may explain brittle diabetes. ( 18568931 )
2008
15
A case of hypoglycemic brittle diabetes with peripheral edema successfully managed by conversion from insulin lispro to insulin aspart. ( 18676048 )
2008
16
Brittle type 1 diabetes mellitus. ( 17627511 )
2007
17
Management strategies for brittle diabetes. ( 17072232 )
2006
18
Usefulness of measuring the gastric emptying time in a case of brittle diabetes. ( 15515755 )
2004
19
Quetiapine in the successful treatment of psychosis and comorbid brittle diabetes mellitus: a case report. ( 15666960 )
2004
20
The myth of brittle diabetes. ( 12908443 )
2003
21
Brittle diabetes in the elderly. ( 11773367 )
2002
22
Brittle diabetes in the elderly. ( 11691895 )
2001
23
[Psychosocial predictors of metabolic instability in brittle diabetes--a multivariate time series analysis]. ( 11447656 )
2001
24
Brittle diabetes characterised by recurrent hypoglycaemia. ( 10566119 )
1999
25
Esophageal stenosis and Graves disease in brittle type 1 diabetes mellitus. ( 9645838 )
1998
26
Brittle diabetes revisited: the Third Arnold Bloom Memorial Lecture. ( 9047086 )
1997
27
Prevalence and characteristics of brittle diabetes in Britain. ( 8977963 )
1996
28
Hormonal response to stress in brittle diabetes. ( 8983089 )
1996
29
Brittle diabetes: etiology and treatment. ( 7671100 )
1995
30
Mortality and outcome of patients with brittle diabetes and recurrent ketoacidosis. ( 7916072 )
1994
31
Brittle diabetes in the young. ( 1369810 )
1992
32
The spectrum of brittle diabetes. ( 1433085 )
1992
33
Brittle diabetes: a report of the First International Conference on Brittle Diabetes. ( 1511575 )
1992
34
A controlled study of psychoanalytic treatment of brittle diabetes. ( 1757442 )
1991
35
Brittle diabetes. ( 1760010 )
1991
36
Successful treatment of unusual case of brittle diabetes with sulfated beef insulin. ( 1797500 )
1991
37
"Brittle" diabetes. ( 1888921 )
1991
38
Outcome of brittle diabetes. ( 1888928 )
1991
39
Course of brittle diabetes: 12 year follow up. ( 1904287 )
1991
40
Iatrogenic brittle diabetes: the hold-the-insulin decision. ( 1995280 )
1991
41
Management of "brittle" diabetes with a preprogrammable implanted insulin pump delivering intraperitoneal insulin. ( 2252927 )
1990
42
Brittle diabetes in the elderly. ( 2527683 )
1989
43
Hypoglycaemic brittle diabetes successfully managed by social worker intervention. ( 2527685 )
1989
44
The natural history of brittle diabetes. ( 3042251 )
1988
45
Brittle diabetes: strategies, diagnosis, and treatment. ( 3292175 )
1988
46
Brittle diabetes in a drug and alcohol abuser. ( 3479175 )
1987
47
The metabolic response to insulin deprivation in idiopathic brittle diabetes. ( 3527516 )
1986
48
Another facet of brittle diabetes. ( 3537346 )
1986
49
The management of severe brittle diabetes with "Infusaid" implantable pumps. ( 3709039 )
1986
50
A clinical algorithm to determine the etiology of brittle diabetes. ( 3882369 )
1985

Variations for Brittle Diabetes

Expression for Brittle Diabetes

Search GEO for disease gene expression data for Brittle Diabetes.

Pathways for Brittle Diabetes

GO Terms for Brittle Diabetes

Sources for Brittle Diabetes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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