ASC
MCID: BRK012
MIFTS: 35

Broken Heart Syndrome (ASC)

Categories: Cardiovascular diseases, Rare diseases

Aliases & Classifications for Broken Heart Syndrome

MalaCards integrated aliases for Broken Heart Syndrome:

Name: Broken Heart Syndrome 52 58
Takotsubo Cardiomyopathy 58 17 71
Transient Left Ventricular Apical Ballooning Syndrome 58 71
Transient Antero-Apical Dyskinesia 52 71
Apical Ballooning Syndrome 52 58
Tako-Tsubo Cardiomyopathy 52 58
Stress Cardiomyopathy 52 58
Tako-Tsubo Syndrome 52 58
Left Ventricular Transient Apical Ballooning 52
Stress-Induced Cardiomyopathy 52
Stress Induced Cardiomyopathy 71
Acute Stress Cardiomyopathy 52
Ballooning Cardiomyopathy 58
Ampulla Cardiomyopathy 58
Broken-Heart Syndrome 52
Tako Tsubo Syndrome 52
Takotsubo Syndrome 58
Asc 52

Characteristics:

Orphanet epidemiological data:

58
tako-tsubo cardiomyopathy
Age of onset: Adult; Age of death: elderly;

Classifications:



External Ids:

ICD10 via Orphanet 33 I42.8
UMLS via Orphanet 72 C1168291 C1739395
Orphanet 58 ORPHA66529
UMLS 71 C1719472 C1719473 C1739395 more

Summaries for Broken Heart Syndrome

NIH Rare Diseases : 52 Broken heart syndrome is a temporary condition that affects the heart. In people with this condition, extreme emotional or physical stress (i.e. intense grief, anger, surprise, illness or surgery) can lead to heart muscle failure. Signs and symptoms of the condition mimic those of a heart attack and may include sudden chest pain, shortness of breath, and an irregular heartbeat. The cause of broken heart syndrome is not completely understood. Some researchers believe that it may occur when certain hormones released during times of stress temporarily affect the heart's ability to pump blood throughout the body. Treatment is available to manage the symptoms of the condition. Fortunately, most affected people have a full and quick recovery with no permanent damage to the heart muscle.

MalaCards based summary : Broken Heart Syndrome, also known as takotsubo cardiomyopathy, is related to cervix uteri carcinoma in situ and cervical intraepithelial neoplasia. The drugs Acetylcarnitine and Folic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and liver.

Wikipedia : 74 Takotsubo cardiomyopathy(TTS), also known as stress cardiomyopathy, is a type of non-ischemic... more...

Related Diseases for Broken Heart Syndrome

Diseases related to Broken Heart Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 570)
# Related Disease Score Top Affiliating Genes
1 cervix uteri carcinoma in situ 10.6
2 cervical intraepithelial neoplasia 10.6
3 atrial standstill 1 10.6
4 baroreflex failure 10.5
5 ischemia 10.5
6 pituitary adenoma 10.4
7 tricuspid valve insufficiency 10.4
8 influenza 10.4
9 rare surgical neurologic disease 10.4
10 myocardial stunning 10.4
11 familial mediterranean fever 10.3
12 follicular lymphoma 10.3
13 multiple sclerosis 10.3
14 neurofibromatosis, type iv, of riccardi 10.3
15 wolff-parkinson-white syndrome 10.3
16 progressive familial heart block, type ib 10.3
17 colorectal adenocarcinoma 10.3
18 visual epilepsy 10.3
19 optic neuritis 10.3
20 locked-in syndrome 10.3
21 quadriplegia 10.3
22 right bundle branch block 10.3
23 thrombocytopenia 10.3
24 pneumothorax 10.3
25 neuritis 10.3
26 cholecystitis 10.3
27 thrombocytosis 10.3
28 myoma 10.3
29 lipid metabolism disorder 10.3
30 seminoma 10.3
31 hemangioblastoma 10.3
32 anterograde amnesia 10.3
33 anterolateral myocardial infarction 10.3
34 panic disorder 10.3
35 lupus erythematosus 10.3
36 achalasia 10.3
37 allergic asthma 10.3
38 seizure disorder 10.3
39 familial long qt syndrome 10.3
40 hyperlipoproteinemia, type iii 10.3
41 coronary artery anomaly 10.3
42 squamous cell papilloma 10.2
43 papilloma 10.2
44 graves' disease 10.2
45 diabetes mellitus 10.2
46 arteries, anomalies of 10.2
47 cervical cancer 10.2
48 peritonitis 10.2
49 tetralogy of fallot 10.2
50 aphasia 10.2

Graphical network of the top 20 diseases related to Broken Heart Syndrome:



Diseases related to Broken Heart Syndrome

Symptoms & Phenotypes for Broken Heart Syndrome

Drugs & Therapeutics for Broken Heart Syndrome

Drugs for Broken Heart Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcarnitine Approved, Investigational Phase 4 3040-38-8 7045767
2
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
3 Trace Elements Phase 4
4 carnitine Phase 4
5 Micronutrients Phase 4
6 Vitamins Phase 4
7 Antioxidants Phase 4
8 Vitamin B Complex Phase 4
9 Nootropic Agents Phase 4
10 Nutrients Phase 4
11 Alpha-lipoic Acid Phase 4
12 Vitamin B9 Phase 4
13 Folate Phase 4
14 Thioctic Acid Phase 4
15
Adenosine Approved, Investigational Phase 2 58-61-7 60961
16 Neurotransmitter Agents Phase 2
17 Vasodilator Agents Phase 2
18 Analgesics Phase 2
19 Anti-Arrhythmia Agents Phase 2
20 Pharmaceutical Solutions Phase 2
21
Acetylcholine Approved, Investigational 51-84-3 187
22
Nitroprusside Approved, Investigational 15078-28-1 11963622
23
Ephedrine Approved 299-42-3 9294
24
Oxymetazoline Approved, Investigational 1491-59-4 4636
25
Phenylephrine Approved 59-42-7 6041
26
Nitric Oxide Approved 10102-43-9 145068
27
Pseudoephedrine Approved 90-82-4 7028
28 3-Iodobenzylguanidine
29 Radiopharmaceuticals
30 Protective Agents
31 Sympathomimetics
32 Antihypertensive Agents
33 Vasoconstrictor Agents
34 Respiratory System Agents
35 Nasal Decongestants
36 Adrenergic Agonists
37 Autonomic Agents
38 Adrenergic Agents
39 Mydriatics
40 Nitric Oxide Donors

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 Sympathetic Heart Innervation in Patients With Previous Experience of Transient Stress-induced Cardiomyopathy (Tako-Tsubo): Effects of α-lipoic Acid and L-acetyl Carnitine Therapies. Completed NCT01524861 Phase 4 Placebo;alpha-lipoic acid;L-acetyl carnitine
2 Rapid Recovery of Left Ventricular Function in Patients With Takotsubo Syndrome Undergoing Systemic Infusion of Adenosine: a Randomized Controlled Trial (TITAN Study) Terminated NCT02867878 Phase 2 Adenosine;Saline solution
3 Event-related Potentials in Patients With Takotsubo Cardiomyopathy Unknown status NCT02361073
4 A Prospective, Multicenter, Observational Registry to Evaluate the Prevalence and Incidence of Cancer and Long-term Prognosis in Patients With Tako-Tsubo (Stress-induced) Cardiomyopathy. Unknown status NCT01944826
5 Incidence, Influencing Factors and Outcome of Takotsubo Cardiomyopathy in Patients Suffering From Acute Non-traumatic Subarachnoid Hemorrhage Unknown status NCT02659878
6 Mindfulness-based Sex Therapy on Patients With Takotsubo Cardiomyopathy Among Iranian Women Unknown status NCT03372577
7 Serial Echocardiography After Subarachnoid Hemorrhage (S.E.A.S.) Unknown status NCT00123695
8 Insights in the Pathophysiology of Transient Left Ventricular Ballooning Syndrome (TLVBS) Unknown status NCT01076946
9 Persistent Symptoms and Early Incomplete Recovery After Acute Stress-induced Cardiomyopathy: Is There Ongoing Heart Distress? The HEROIC Study Completed NCT02989454
10 The Evaluation of the Pathogenesis of Stress-Induced Cardiomyopathy by I-123 MIBG Imaging Completed NCT01432626 I-123 radiolabeled metaiodobenzylguanidine cardiac imaging
11 Stress-induced Vascular Dysfunction: Evaluation of Endothelial Function in a Cohort of Patients With Takotsubo Syndrome Completed NCT01249599
12 Pathogenesis of Acute Stress Induced (Tako-tsubo) Cardiomyopathy: Energy Shut-Down or Intense Inflammation? The TERRIFIC Study Completed NCT02897739
13 Genetic Polymorphisms in Catecholamine Pathway Responsible for the Tako-TSUBO Cardiomyopathy Susceptibly (TAKO-GENE) Completed NCT01520610
14 French Observatory Syndromes Tako-Tsubo Completed NCT01252004
15 Personality Profile of Patients With Apical Ballooning Syndrome (ABS) Completed NCT01885975
16 Tako-Tsubo Cardiomyopathy and Cardiac Syndrome X: a Study on the Brain-heart Interactions in Two Orphan Cardiac Diseases. Completed NCT02759341
17 Tako-Tsubo Cardiomyopathy and Cardiac Syndrome X: New Insights Into the Pathophysiology of Two Orphan Cardiac Diseases Completed NCT02307214
18 The Relationship Between the Response to Mental Stress and Vascular Endothelial Function Completed NCT00975559
19 Cardiac Sympathetic Activity in Patients With the Apical Ballooning Syndrome Completed NCT00586183
20 Pilot Study: Central Nervous System and Hormonal Changes In Takotsubo Cardiomyopathy Completed NCT02240056
21 The Brain Heart Interaction in Acute Stroke Completed NCT02734082
22 Early Insurgence of Coronary Artery Dysfunction in Prediabetic Patients With Monovessel Non Obstructive Coronary Stenosis May Condition Major Adverse Cardiac Events at 24 Months of Follow up. Completed NCT03553030
23 Stockholm Myocardial Infarction With Normal Coronaries (SMINC)-2 Completed NCT02318498
24 NYU Takotsubo (Broken Heart Syndrome) Registry Recruiting NCT03663348
25 International Multicenter Registry on Takotsubo Cardiomyopathy Recruiting NCT01947621
26 Retrospective and Prospective Observational Study on Cardiological and Oncological Psychosomatics Recruiting NCT03437642
27 Establishing the Incidence of Tako-tsubo Cardiomyopathy in Scotland - the STARR Study Recruiting NCT03299569
28 Optimized Characterization of Takotsubo Syndrome by Obtaining Pressure Volume Loops Recruiting NCT03726528
29 To Evaluate the Role of Plasma Catecholamine Levels in Predicting the Development of Myocardial Depression in Acute Neurological Patients Recruiting NCT03801694
30 Detection of Myocardial Dysfunction in Non-severe Subarachnoid Hemorrhage (WFNS 1-2) Using Speckle-tracking Echocardiography (STRAIN) Recruiting NCT03761654
31 Etiology of Myocardial Injury Following Non-cardiac Surgery - a Prospective Clinical Trial Recruiting NCT03317561
32 Smidt Heart Institute Takotsubo Registry Recruiting NCT03910569
33 Essential Arterial Hypotension and Allostasis Registry Recruiting NCT02018497
34 Early Cardiac Magnetic Resonance Imaging in Suspected Non-ST-Elevation Myocardial Infarction: An Observational Two-Center Study Recruiting NCT04140019
35 Left Ventricular Dysfunction in Critically Ill Patients Active, not recruiting NCT03787810
36 Canadian Spontaneous Coronary Artery Dissection (SCAD) Cohort Study Active, not recruiting NCT02188069
37 Autonomic Modulation in Takotsubo Syndrome Not yet recruiting NCT03324529
38 E-health Treatment in Stockholm Myocardial Infarction With None-obstructive Coronaries Study Not yet recruiting NCT04178434
39 Characterization of Sympathetic Nerve Activity in Stress Cardiomyopathy Terminated NCT01048125 The Modified Oxford Technique for Baroreflex Sensitivity

Search NIH Clinical Center for Broken Heart Syndrome

Genetic Tests for Broken Heart Syndrome

Anatomical Context for Broken Heart Syndrome

MalaCards organs/tissues related to Broken Heart Syndrome:

40
Heart, Brain, Liver, Lung, Kidney, T Cells, Thyroid

Publications for Broken Heart Syndrome

Articles related to Broken Heart Syndrome:

(show top 50) (show all 2255)
# Title Authors PMID Year
1
Mid-Cavity Variant Takotsubo Cardiomyopathy-Magnetic Resonance Imaging Findings. 61
29754861 2020
2
Reverse Takotsubo Cardiomyopathy After Caesarean Section With Epidural Anesthesia: Initial Assessment and Follow-up. 61
31732378 2020
3
Takotsubo cardiomyopathy complicated by cardiac tamponade due to non-hemorrhagic pericardial effusion: a case report. 61
32028901 2020
4
Myasthenic crises triggering Takotsubo cardiomyopathy. 61
31928654 2020
5
Reply to: Myasthenic crises triggering Takotsubo cardiomyopathy. 61
31928653 2020
6
Takotsubo cardiomyopathy: Review of broken heart syndrome. 61
32039951 2020
7
Newer Insights Into Takotsubo Cardiomyopathy. 61
31982085 2020
8
The three faces of takotsubo cardiomyopathy in a single patient. 61
31841220 2020
9
Takotsubo cardiomyopathy caused by infusion reaction to trastuzumab. 61
31950014 2020
10
Mid-Ventricular Takotsubo Cardiomyopathy with Hawk's Beak Appearance: A Case Report. 61
31894138 2020
11
Biomarkers in patients with Takotsubo cardiomyopathy compared to patients with acute anterior ST-elevation myocardial infarction. 61
31902247 2020
12
A case of bronchospasm-induced takotsubo cardiomyopathy during adenosine stress testing. 61
31897998 2020
13
Time Course of Functional Recovery and ECG Change in Takotsubo Cardiomyopathy. 61
31997609 2020
14
Takotsubo cardiomyopathy triggered by delirium tremens in a cirrhotic patient with acute-on-chronic liver failure: A case report. 61
31928968 2020
15
Frequency of takotsubo cardiomyopathy in epilepsy-related hospitalizations among adults and its impact on in-hospital outcomes: A national standpoint. 61
31327513 2020
16
Time Course of Functional Recovery in Takotsubo (Stress) Cardiomyopathy: A Serial Speckle Tracking Echocardiography and Electrocardiography Study. 61
31997608 2020
17
Rare Association of Takotsubo Cardiomyopathy with Right Bundle Branch Block in the Dual Setting of Asthma Exacerbation and Psychiatric Illness. 61
31959739 2020
18
Reverse Takotsubo Pattern in the Setting of Undiagnosed Pheochromocytoma and Pulmonary Embolism: A Rare Presentation. 61
31949122 2020
19
High-Resolution Late Gadolinium Enhancement Magnetic Resonance for the Diagnosis of Myocardial Infarction With Nonobstructed Coronary Arteries. 61
31954658 2020
20
An Unusual Case of Shock Following an Elective Caesarean Delivery. 61
31324480 2020
21
Takotsubo syndrome: voices to be heard. 61
31686533 2020
22
Psychosocial and physical long-term outcome in patients with a history of takotsubo cardiomyopathy or myocardial infarction - a multi-centered case control study. 61
32000523 2020
23
Midventricular Takotsubo cardiomyopathy complicated by a ventricular septal rupture: a surgical management. 61
31449176 2019
24
Silent left ventricular apical ballooning and Takotsubo cardiomyopathy in an Australian intensive care unit. 61
31556249 2019
25
Comprehensive echocardiographic assessment of takotsubo cardiomyopathy case due to opioids withdrawal. 61
31006503 2019
26
Doxorubicin-associated takotsubo cardiomyopathy in a patient with adult T-cell leukemia/lymphoma. 61
31893081 2019
27
A case of Takotsubo cardiomyopathy with cardiogenic shock after influenza infection successfully recovered by IMPELLA support. 61
31228028 2019
28
Takotsubo (stress) cardiomyopathy in childhood. 61
31865427 2019
29
"Hidden" takotsubo cardiomyopathy in cardiac care unit. 61
31834614 2019
30
A case of pheochromocytoma presenting with cardiopulmonary arrest. 61
31762839 2019
31
Electrocardiographic changes in the differentiation of ischemic and non-ischemic ST elevation. 61
31885293 2019
32
Sex differences in heart failure. 61
31800034 2019
33
Cardiogenic shock triggered by phaeochromocytoma crisis after an oral glucose tolerance test: a case report. 61
31911981 2019
34
Takotsubo cardiomyopathy as a consequence of acute anxiety in a patient with Alzheimer's disease associated with Lewy body disease. 61
31881111 2019
35
Implications of Left Bundle Branch Block in Takotsubo Cardiomyopathy: Propensity Match Analysis from the National Inpatient Sample. 61
31317468 2019
36
Fluorouracil-induced Takotsubo cardiomyopathy causing cardiogenic shock: a case report of clinical and acute cardiac magnetic resonance imaging features. 61
31911978 2019
37
Silent takotsubo cardiomyopathy after cryoballoon ablation. 61
31257416 2019
38
Clinical features differentiating Takotsubo cardiomyopathy in the peripartum period from peripartum cardiomyopathy. 61
31705186 2019
39
Takotsubo Cardiomyopathy in a Rural Australian Population: Preliminary Observations. 61
31839363 2019
40
Lamotrigine-induced hemophagocytic lymphohistiocytosis with Takotsubo cardiomyopathy: a case report. 61
31767022 2019
41
Reverse Takotsubo cardiomyopathy after intravenous glycopyrrolate administration postpartum. 61
31547968 2019
42
Silent takotsubo cardiomyopathy after cryoballoon ablation: Author's reply. 61
31495896 2019
43
Concominant hypertrophic and takotsubo cardiomyopathy; cardiac magnetic resonance with parametric mapping findings after acute phase. 61
31760511 2019
44
Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy. 61
31269802 2019
45
Thoracic Epidural Blockade for Ventricular Tachycardia Storm in Patient with Takotsubo Cardiomyopathy. 61
31911746 2019
46
Atypical takotsubo cardiomyopathy with left ventricular apical wall sparing: A case report and literature review. 61
31752657 2019
47
Acute Cardiac Failure Due to Takotsubo Cardiomyopathy Secondary to a Phone Call for Lung Transplantation: A Case Report. 61
31619342 2019
48
Predictors of 90-Day Readmission and in-Hospital Mortality in Takotsubo Cardiomyopathy: An Analysis of 28,079 Index Admissions. 61
31488362 2019
49
Analysis of Heart Rate Variability in a Patient with Takotsubo Cardiomyopathy Syndrome on the Actual Onset Day. 61
31666453 2019
50
Biopsy detection and clinical management of acute lymphocytic myocarditis in pregnancy. 61
31719936 2019

Variations for Broken Heart Syndrome

Expression for Broken Heart Syndrome

Search GEO for disease gene expression data for Broken Heart Syndrome.

Pathways for Broken Heart Syndrome

GO Terms for Broken Heart Syndrome

Sources for Broken Heart Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....