ASC
MCID: BRK012
MIFTS: 36

Broken Heart Syndrome (ASC)

Categories: Cardiovascular diseases, Rare diseases

Aliases & Classifications for Broken Heart Syndrome

MalaCards integrated aliases for Broken Heart Syndrome:

Name: Broken Heart Syndrome 53 59
Takotsubo Cardiomyopathy 59 17 72
Transient Left Ventricular Apical Ballooning Syndrome 59 72
Transient Antero-Apical Dyskinesia 53 72
Apical Ballooning Syndrome 53 59
Tako-Tsubo Cardiomyopathy 53 59
Stress Cardiomyopathy 53 59
Tako-Tsubo Syndrome 53 59
Left Ventricular Transient Apical Ballooning 53
Stress-Induced Cardiomyopathy 53
Stress Induced Cardiomyopathy 72
Acute Stress Cardiomyopathy 53
Ballooning Cardiomyopathy 59
Ampulla Cardiomyopathy 59
Broken-Heart Syndrome 53
Tako Tsubo Syndrome 53
Takotsubo Syndrome 59
Asc 53

Characteristics:

Orphanet epidemiological data:

59
tako-tsubo cardiomyopathy
Age of onset: Adult; Age of death: elderly;

Classifications:



External Ids:

ICD10 via Orphanet 34 I42.8
UMLS via Orphanet 73 C1168291 C1739395
Orphanet 59 ORPHA66529
UMLS 72 C1719472 C1719473 C1739395 more

Summaries for Broken Heart Syndrome

NIH Rare Diseases : 53 Broken heart syndrome is a temporary condition that affects the heart. In people with this condition, extreme emotional or physical stress (i.e. intense grief, anger, surprise, illness or surgery) can lead to heart muscle failure. Signs and symptoms of the condition mimic those of a heart attack and may include sudden chest pain, shortness of breath, and an irregular heartbeat. The cause of broken heart syndrome is not completely understood. Some researchers believe that it may occur when certain hormones released during times of stress temporarily affect the heart's ability to pump blood throughout the body. Treatment is available to manage the symptoms of the condition. Fortunately, most affected people have a full and quick recovery with no permanent damage to the heart muscle.

MalaCards based summary : Broken Heart Syndrome, also known as takotsubo cardiomyopathy, is related to cervix uteri carcinoma in situ and cervical intraepithelial neoplasia. The drugs Acetylcarnitine and Folic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and liver.

Wikipedia : 75 Takotsubo cardiomyopathy, also known as stress cardiomyopathy, is a type of non-ischemic cardiomyopathy... more...

Related Diseases for Broken Heart Syndrome

Diseases related to Broken Heart Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 562)
# Related Disease Score Top Affiliating Genes
1 cervix uteri carcinoma in situ 10.7
2 cervical intraepithelial neoplasia 10.7
3 atrial standstill 1 10.6
4 baroreflex failure 10.5
5 ischemia 10.4
6 pituitary adenoma 10.4
7 tricuspid valve insufficiency 10.4
8 influenza 10.4
9 rare surgical neurologic disease 10.4
10 myocardial stunning 10.4
11 familial mediterranean fever 10.3
12 follicular lymphoma 10.3
13 multiple sclerosis 10.3
14 neurofibromatosis, type iv, of riccardi 10.3
15 wolff-parkinson-white syndrome 10.3
16 progressive familial heart block, type ib 10.3
17 colorectal adenocarcinoma 10.3
18 visual epilepsy 10.3
19 optic neuritis 10.3
20 locked-in syndrome 10.3
21 quadriplegia 10.3
22 right bundle branch block 10.3
23 pneumothorax 10.3
24 neuritis 10.3
25 cholecystitis 10.3
26 thrombocytosis 10.3
27 myoma 10.3
28 lipid metabolism disorder 10.3
29 seminoma 10.3
30 hemangioblastoma 10.3
31 anterograde amnesia 10.3
32 anterolateral myocardial infarction 10.3
33 panic disorder 10.3
34 lupus erythematosus 10.3
35 achalasia 10.3
36 allergic asthma 10.3
37 seizure disorder 10.3
38 familial long qt syndrome 10.3
39 hyperlipoproteinemia, type iii 10.3
40 coronary artery anomaly 10.3
41 graves' disease 10.2
42 diabetes mellitus 10.2
43 arteries, anomalies of 10.2
44 cervical cancer 10.2
45 squamous cell papilloma 10.2
46 papilloma 10.2
47 peritonitis 10.2
48 tetralogy of fallot 10.2
49 aphasia 10.2
50 epilepsy 10.2

Graphical network of the top 20 diseases related to Broken Heart Syndrome:



Diseases related to Broken Heart Syndrome

Symptoms & Phenotypes for Broken Heart Syndrome

Drugs & Therapeutics for Broken Heart Syndrome

Drugs for Broken Heart Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcarnitine Approved, Investigational Phase 4 3040-38-8 7045767
2
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
3 Micronutrients Phase 4
4 Trace Elements Phase 4
5 Antioxidants Phase 4
6 Nootropic Agents Phase 4
7 Alpha-lipoic Acid Phase 4
8 carnitine Phase 4
9 Vitamins Phase 4
10 Vitamin B9 Phase 4
11 Folate Phase 4
12 Vitamin B Complex Phase 4
13 Thioctic Acid Phase 4
14 Nutrients Phase 4
15
Adenosine Approved, Investigational Phase 2 58-61-7 60961
16 Neurotransmitter Agents Phase 2
17 Peripheral Nervous System Agents Phase 2
18 Vasodilator Agents Phase 2
19 Analgesics Phase 2
20 Purinergic P1 Receptor Agonists Phase 2
21 Pharmaceutical Solutions Phase 2
22 Anti-Arrhythmia Agents Phase 2
23
Acetylcholine Approved, Investigational 51-84-3 187
24
Nitroprusside Approved, Investigational 15078-28-1 11963622
25
Nitric Oxide Approved 10102-43-9 145068
26
Oxymetazoline Approved, Investigational 1491-59-4 4636
27
Phenylephrine Approved 59-42-7 6041
28
Ephedrine Approved 299-42-3 9294
29
Pseudoephedrine Approved 90-82-4 7028
30 3-Iodobenzylguanidine
31 Radiopharmaceuticals
32 Protective Agents
33 Antihypertensive Agents
34 Cardiotonic Agents
35 Nitric Oxide Donors
36 Sympathomimetics
37 Adrenergic Agonists
38 Nasal Decongestants
39 Respiratory System Agents
40 Mydriatics
41 Adrenergic alpha-Agonists
42 Adrenergic Agents
43 Vasoconstrictor Agents
44 Autonomic Agents

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 Sympathetic Heart Innervation in Patients With Previous Experience of Transient Stress-induced Cardiomyopathy (Tako-Tsubo): Effects of α-lipoic Acid and L-acetyl Carnitine Therapies. Completed NCT01524861 Phase 4 Placebo;alpha-lipoic acid;L-acetyl carnitine
2 Rapid Recovery of Left Ventricular Function in Patients With Takotsubo Syndrome Undergoing Systemic Infusion of Adenosine: a Randomized Controlled Trial (TITAN Study) Terminated NCT02867878 Phase 2 Adenosine;Saline solution
3 Event-related Potentials in Patients With Takotsubo Cardiomyopathy Unknown status NCT02361073
4 A Prospective, Multicenter, Observational Registry to Evaluate the Prevalence and Incidence of Cancer and Long-term Prognosis in Patients With Tako-Tsubo (Stress-induced) Cardiomyopathy. Unknown status NCT01944826
5 Incidence, Influencing Factors and Outcome of Takotsubo Cardiomyopathy in Patients Suffering From Acute Non-traumatic Subarachnoid Hemorrhage Unknown status NCT02659878
6 Serial Echocardiography After Subarachnoid Hemorrhage (S.E.A.S.) Unknown status NCT00123695
7 Insights in the Pathophysiology of Transient Left Ventricular Ballooning Syndrome (TLVBS) Unknown status NCT01076946
8 Persistent Symptoms and Early Incomplete Recovery After Acute Stress-induced Cardiomyopathy: Is There Ongoing Heart Distress? The HEROIC Study Completed NCT02989454
9 The Evaluation of the Pathogenesis of Stress-Induced Cardiomyopathy by I-123 MIBG Imaging Completed NCT01432626 I-123 radiolabeled metaiodobenzylguanidine cardiac imaging
10 Stress-induced Vascular Dysfunction: Evaluation of Endothelial Function in a Cohort of Patients With Takotsubo Syndrome Completed NCT01249599
11 Pathogenesis of Acute Stress Induced (Tako-tsubo) Cardiomyopathy: Energy Shut-Down or Intense Inflammation? The TERRIFIC Study Completed NCT02897739
12 Genetic Polymorphisms in Catecholamine Pathway Responsible for the Tako-TSUBO Cardiomyopathy Susceptibly (TAKO-GENE) Completed NCT01520610
13 French Observatory Syndromes Tako-Tsubo Completed NCT01252004
14 Personality Profile of Patients With Apical Ballooning Syndrome (ABS) Completed NCT01885975
15 Tako-Tsubo Cardiomyopathy and Cardiac Syndrome X: a Study on the Brain-heart Interactions in Two Orphan Cardiac Diseases. Completed NCT02759341
16 Tako-Tsubo Cardiomyopathy and Cardiac Syndrome X: New Insights Into the Pathophysiology of Two Orphan Cardiac Diseases Completed NCT02307214
17 The Relationship Between the Response to Mental Stress and Vascular Endothelial Function Completed NCT00975559
18 Cardiac Sympathetic Activity in Patients With the Apical Ballooning Syndrome Completed NCT00586183
19 Pilot Study: Central Nervous System and Hormonal Changes In Takotsubo Cardiomyopathy Completed NCT02240056
20 The Brain Heart Interaction in Acute Stroke Completed NCT02734082
21 Early Insurgence of Coronary Artery Dysfunction in Prediabetic Patients With Monovessel Non Obstructive Coronary Stenosis May Condition Major Adverse Cardiac Events at 24 Months of Follow up. Completed NCT03553030
22 NYU Takotsubo (Broken Heart Syndrome) Registry Recruiting NCT03663348
23 International Multicenter Registry on Takotsubo Cardiomyopathy Recruiting NCT01947621
24 Retrospective and Prospective Observational Study on Cardiological and Oncological Psychosomatics Recruiting NCT03437642
25 Establishing the Incidence of Tako-tsubo Cardiomyopathy in Scotland - the STARR Study Recruiting NCT03299569
26 Optimized Characterization of Takotsubo Syndrome by Obtaining Pressure Volume Loops Recruiting NCT03726528
27 Left Ventricular Dysfunction in Critically Ill Patients Recruiting NCT03787810
28 To Evaluate the Role of Plasma Catecholamine Levels in Predicting the Development of Myocardial Depression in Acute Neurological Patients Recruiting NCT03801694
29 Mindfulness-based Sex Therapy on Patients With Takotsubo Cardiomyopathy Among Iranian Women Recruiting NCT03372577
30 Detection of Myocardial Dysfunction in Non-severe Subarachnoid Hemorrhage (WFNS 1-2) Using Speckle-tracking Echocardiography (STRAIN) Recruiting NCT03761654
31 Etiology of Myocardial Injury Following Non-cardiac Surgery - a Prospective Clinical Trial Recruiting NCT03317561
32 Smidt Heart Institute Takotsubo Registry Recruiting NCT03910569
33 Stockholm Myocardial Infarction With Normal Coronaries (SMINC)-2 Recruiting NCT02318498
34 Essential Arterial Hypotension and Allostasis Registry Recruiting NCT02018497
35 Canadian Spontaneous Coronary Artery Dissection (SCAD) Cohort Study Active, not recruiting NCT02188069
36 Autonomic Modulation in Takotsubo Syndrome Not yet recruiting NCT03324529
37 Characterization of Sympathetic Nerve Activity in Stress Cardiomyopathy Terminated NCT01048125 The Modified Oxford Technique for Baroreflex Sensitivity

Search NIH Clinical Center for Broken Heart Syndrome

Genetic Tests for Broken Heart Syndrome

Anatomical Context for Broken Heart Syndrome

MalaCards organs/tissues related to Broken Heart Syndrome:

41
Heart, Brain, Liver, Endothelial, Lung, Testes, Kidney

Publications for Broken Heart Syndrome

Articles related to Broken Heart Syndrome:

(show top 50) (show all 2167)
# Title Authors PMID Year
1
Biventricular takotsubo cardiomyopathy with asymmetrical wall motion abnormality between left and right ventricle: a report of new case and literature review. 38
30905042 2019
2
Neurogenic Stress Cardiomyopathy Following Subarachnoid Hemorrhage Is Associated with Vagal Complex Degeneration: First Experimental Study. 38
31201944 2019
3
Takotsubo Cardiomyopathy After Double-Lung Transplantation: Role of Early Extracorporeal Membrane Oxygenation Support. 38
30579661 2019
4
A case report of a giant hiatal hernia mimicking an ST-elevation myocardial infarction. 38
31425572 2019
5
Pheochromocytoma- and paraganglioma-triggered Takotsubo syndrome. 38
31399912 2019
6
A unique case of acute brain haemorrhage with left ventricular systolic failure requiring ECMO. 38
31409401 2019
7
Assessment of the German and Italian Stress Cardiomyopathy Score for Risk Stratification for In-hospital Complications in Patients With Takotsubo Syndrome. 38
31389988 2019
8
A case of esophagogastroduodenoscopy induced Takotsubo cardiomyopathy with complete heart block. 38
30904984 2019
9
Comparison of mortality in primary and secondary Takotsubo cardiomyopathy with severe left ventricular dysfunction. 38
30983077 2019
10
Comparison of mortality in primary and secondary Takotsubo cardiomyopathy with severe left ventricular dysfunction: reply. 38
31111985 2019
11
Severe takotsubo cardiomyopathy following orthotopic liver transplantation: A case series. 38
30853493 2019
12
Recurrent Takotsubo syndrome in a boy with Duchenne muscular dystrophy: A case report. 38
31320947 2019
13
Head Rules Over the Heart: Cardiac Manifestations of Cerebral Disorders. 38
31406441 2019
14
Head Rules Over the Heart: Cardiac Manifestations of Cerebral Disorders. 38
31406442 2019
15
Transient left ventricular acute failure after Cocaine Use. 38
31333135 2019
16
An Unusual Case of Shock Following an Elective Caesarean Delivery. 38
31324480 2019
17
Response to letter of the editor "Mortality in Takotsubo Cardiomyopathy should also be accounted based on predisposing etiology". 38
31155805 2019
18
Frequency of takotsubo cardiomyopathy in epilepsy-related hospitalizations among adults and its impact on in-hospital outcomes: A national standpoint. 38
31327513 2019
19
Implications of Left Bundle Branch Block in Takotsubo Cardiomyopathy: Propensity Match Analysis from the National Inpatient Sample. 38
31317468 2019
20
Takotsubo Cardiomyopathy: Medical and Psychiatric Aspects. Role of Psychotropic Medications in the Treatment of Adults with "Broken Heart" Syndrome. 38
31423403 2019
21
Perioperative takotsubo cardiomyopathy: Implications for anesthesiologist. 38
31274495 2019
22
Severe Tetanus Complicated by Takotsubo Cardiomyopathy. 38
30918197 2019
23
Hypothermia-triggered biventricular Takotsubo cardiomyopathy: the octopus that survived the polar vortex. 38
31352387 2019
24
Mortality in Takotsubo cardiomyopathy should also be accounted based on predisposing etiology. 38
31155779 2019
25
Central autonomic network and Takotsubo cardiomyopathy: how left insular cortex interact? 38
31302672 2019
26
Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy. 38
31269802 2019
27
Cardiogenic Shock in Takotsubo Cardiomyopathy Versus Acute Myocardial Infarction: An 8-Year National Perspective on Clinical Characteristics, Management, and Outcomes. 38
31078481 2019
28
For "Broken Heart" Syndrome, Brain May Hold the Key. 38
31141117 2019
29
Takotsubo cardiomyopathy occurring concomitantly with uterine rupture due to caesarian scar pregnancy: A case report. 38
31262441 2019
30
Shock begets shock: A case of direct current cardioversion-induced takotsubo cardiomyopathy. 38
31285987 2019
31
A case of Takotsubo cardiomyopathy with cardiogenic shock after influenza infection successfully recovered by IMPELLA support. 38
31228028 2019
32
Takotsubo Cardiomyopathy Mimicking Acute Coronary Syndrome - Extracellular Volume Quantification Using Cardiac Computed Tomography. 38
30568048 2019
33
Stressing Out from the Flu: A Case of Influenza A-associated Transient Cardiomyopathy. 38
31423394 2019
34
Takotsubo cardiomyopathy: prognostication is affected by the underlying trigger: the reply. 38
31045856 2019
35
Electroconvulsive Therapy for Depression with Recent Takotsubo Cardiomyopathy: A Case Report. 38
30346351 2019
36
Silent takotsubo cardiomyopathy after cryoballoon ablation. 38
31257416 2019
37
Takotsubo cardiomyopathy: prognostication is affected by the underlying trigger. 38
31045855 2019
38
Reverse takotsubo cardiomyopathy triggered by a multiple sclerosis relapse. 38
30506163 2019
39
The spectrum of acute cardiopulmonary events associated with multiple sclerosis exacerbations. 38
30657008 2019
40
Acute mitral regurgitation. 38
30824479 2019
41
Can acute stress be fatal? A systematic cross-disciplinary review. 38
30767612 2019
42
Mechanisms of ST Elevation Myocardial Infarction in Patients Hospitalized for Noncardiac Conditions. 38
30773247 2019
43
A somnolent woman in her fifties with acute circulatory failure. 38
31140247 2019
44
Takotsubo cardiomyopathy, or 'broken-heart syndrome', with concomitant myasthenic crisis. 38
31187145 2019
45
Takotsubo cardiomyopathy associated with cerebral infarction following surgery for euthyroid goiter. 38
31103314 2019
46
Takotsubo Cardiomyopathy Complicated with Left Ventricular Thrombus in Myasthenic Crisis: A Case Report. 38
31129678 2019
47
Intraventricular thrombus and severe mitral regurgitation in the acute phase of takotsubo cardiomyopathy: two case reports. 38
31103033 2019
48
Takotsubo cardiomyopathy in a man with no trigger and multiple cardioembolic complications-A rare constellation. 38
30957272 2019
49
Cardiogenic shock induced by Takotsubo cardiomyopathy in early postoperative adrenalectomy period. 38
30665798 2019
50
Referral to Cardiac Rehabilitation and Outcomes for Patients With Takotsubo Cardiomyopathy. 38
31022006 2019

Variations for Broken Heart Syndrome

Expression for Broken Heart Syndrome

Search GEO for disease gene expression data for Broken Heart Syndrome.

Pathways for Broken Heart Syndrome

GO Terms for Broken Heart Syndrome

Sources for Broken Heart Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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