ASC
MCID: BRK012
MIFTS: 35

Broken Heart Syndrome (ASC)

Categories: Cardiovascular diseases, Rare diseases

Aliases & Classifications for Broken Heart Syndrome

MalaCards integrated aliases for Broken Heart Syndrome:

Name: Broken Heart Syndrome 52 58
Takotsubo Cardiomyopathy 58 17 71
Transient Left Ventricular Apical Ballooning Syndrome 58 71
Transient Antero-Apical Dyskinesia 52 71
Apical Ballooning Syndrome 52 58
Tako-Tsubo Cardiomyopathy 52 58
Stress Cardiomyopathy 52 58
Tako-Tsubo Syndrome 52 58
Left Ventricular Transient Apical Ballooning 52
Stress-Induced Cardiomyopathy 52
Stress Induced Cardiomyopathy 71
Acute Stress Cardiomyopathy 52
Ballooning Cardiomyopathy 58
Ampulla Cardiomyopathy 58
Broken-Heart Syndrome 52
Tako Tsubo Syndrome 52
Takotsubo Syndrome 58
Asc 52

Characteristics:

Orphanet epidemiological data:

58
tako-tsubo cardiomyopathy
Age of onset: Adult; Age of death: elderly;

Classifications:



External Ids:

ICD10 via Orphanet 33 I42.8
UMLS via Orphanet 72 C1168291 C1739395
Orphanet 58 ORPHA66529
UMLS 71 C1719472 C1719473 C1739395 more

Summaries for Broken Heart Syndrome

NIH Rare Diseases : 52 Broken heart syndrome is a temporary condition that affects the heart. In people with this condition, extreme emotional or physical stress (i.e. intense grief, anger, surprise, illness or surgery) can lead to heart muscle failure. Signs and symptoms of the condition mimic those of a heart attack and may include sudden chest pain, shortness of breath, and an irregular heartbeat. The cause of broken heart syndrome is not completely understood. Some researchers believe that it may occur when certain hormones released during times of stress temporarily affect the heart's ability to pump blood throughout the body. Treatment is available to manage the symptoms of the condition. Fortunately, most affected people have a full and quick recovery with no permanent damage to the heart muscle.

MalaCards based summary : Broken Heart Syndrome, also known as takotsubo cardiomyopathy, is related to cervix uteri carcinoma in situ and cervical intraepithelial neoplasia. The drugs Acetylcarnitine and Folic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and liver.

Wikipedia : 74 Takotsubo cardiomyopathy or Takotsubo syndrome (TTS), also known as stress cardiomyopathy, is a type of... more...

Related Diseases for Broken Heart Syndrome

Diseases related to Broken Heart Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 584)
# Related Disease Score Top Affiliating Genes
1 cervix uteri carcinoma in situ 10.7
2 cervical intraepithelial neoplasia 10.7
3 atrial standstill 1 10.6
4 baroreflex failure 10.5
5 ischemia 10.5
6 pituitary adenoma 10.4
7 tricuspid valve insufficiency 10.4
8 influenza 10.4
9 myocardial stunning 10.4
10 familial mediterranean fever 10.3
11 brucellosis 10.3
12 follicular lymphoma 10.3
13 wolff-parkinson-white syndrome 10.3
14 progressive familial heart block, type ib 10.3
15 colorectal adenocarcinoma 10.3
16 visual epilepsy 10.3
17 optic neuritis 10.3
18 quadriplegia 10.3
19 right bundle branch block 10.3
20 thrombocytopenia 10.3
21 pneumothorax 10.3
22 neuritis 10.3
23 cholecystitis 10.3
24 thrombocytosis 10.3
25 myoma 10.3
26 lipid metabolism disorder 10.3
27 seminoma 10.3
28 hemangioblastoma 10.3
29 anterograde amnesia 10.3
30 anterolateral myocardial infarction 10.3
31 panic disorder 10.3
32 neurofibromatosis 10.3
33 achalasia 10.3
34 allergic asthma 10.3
35 seizure disorder 10.3
36 familial long qt syndrome 10.3
37 squamous cell papilloma 10.2
38 papilloma 10.2
39 graves' disease 10.2
40 epilepsy 10.2
41 diabetes mellitus 10.2
42 arteries, anomalies of 10.2
43 hyperlipoproteinemia, type iii 10.2
44 lipoprotein quantitative trait locus 10.2
45 cervical cancer 10.2
46 peritonitis 10.2
47 tetralogy of fallot 10.2
48 aphasia 10.2
49 autoimmune disease 10.2
50 coronary artery vasospasm 10.2

Graphical network of the top 20 diseases related to Broken Heart Syndrome:



Diseases related to Broken Heart Syndrome

Symptoms & Phenotypes for Broken Heart Syndrome

Drugs & Therapeutics for Broken Heart Syndrome

Drugs for Broken Heart Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcarnitine Approved, Investigational Phase 4 3040-38-8 7045767
2
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
3 Micronutrients Phase 4
4 Alpha-lipoic Acid Phase 4
5 Trace Elements Phase 4
6 Vitamins Phase 4
7 Antioxidants Phase 4
8 Vitamin B Complex Phase 4
9 carnitine Phase 4
10 Folate Phase 4
11 Nutrients Phase 4
12 Thioctic Acid Phase 4
13 Vitamin B9 Phase 4
14
Aspirin Approved, Vet_approved Phase 2, Phase 3 50-78-2 2244
15 Analgesics Phase 2, Phase 3
16 Analgesics, Non-Narcotic Phase 2, Phase 3
17 Fibrinolytic Agents Phase 2, Phase 3
18 Platelet Aggregation Inhibitors Phase 2, Phase 3
19 Antiviral Agents Phase 2, Phase 3
20 Cyclooxygenase Inhibitors Phase 2, Phase 3
21 Antipyretics Phase 2, Phase 3
22 Anti-Inflammatory Agents Phase 2, Phase 3
23 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
24 Antirheumatic Agents Phase 2, Phase 3
25
Adenosine Approved, Investigational Phase 2 58-61-7 60961
26 Neurotransmitter Agents Phase 2
27 Vasodilator Agents Phase 2
28 Pharmaceutical Solutions Phase 2
29 Anti-Arrhythmia Agents Phase 2
30
Acetylcholine Approved, Investigational 51-84-3 187
31
Phenylephrine Approved 59-42-7 6041
32
Nitric Oxide Approved 10102-43-9 145068
33
Nitroprusside Approved, Investigational 15078-28-1 11963622
34
Pseudoephedrine Approved 90-82-4 7028
35
Ephedrine Approved 299-42-3 9294
36
Oxymetazoline Approved, Investigational 1491-59-4 4636
37 3-Iodobenzylguanidine
38 Radiopharmaceuticals
39 Fluorodeoxyglucose F18
40 Protective Agents
41 Adrenergic alpha-Agonists
42 Respiratory System Agents
43 Cardiotonic Agents
44 Antihypertensive Agents
45 Adrenergic Agents
46 Nasal Decongestants
47 Vasoconstrictor Agents
48 Mydriatics
49 Sympathomimetics
50 Adrenergic Agonists

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Sympathetic Heart Innervation in Patients With Previous Experience of Transient Stress-induced Cardiomyopathy (Tako-Tsubo): Effects of α-lipoic Acid and L-acetyl Carnitine Therapies. Completed NCT01524861 Phase 4 Placebo;alpha-lipoic acid;L-acetyl carnitine
2 Protective Effect of Aspirin on COVID-19 Patients Enrolling by invitation NCT04365309 Phase 2, Phase 3 Aspirin 100mg
3 Rapid Recovery of Left Ventricular Function in Patients With Takotsubo Syndrome Undergoing Systemic Infusion of Adenosine: a Randomized Controlled Trial (TITAN Study) Terminated NCT02867878 Phase 2 Adenosine;Saline solution
4 Event-related Potentials in Patients With Takotsubo Cardiomyopathy Unknown status NCT02361073
5 A Prospective, Multicenter, Observational Registry to Evaluate the Prevalence and Incidence of Cancer and Long-term Prognosis in Patients With Tako-Tsubo (Stress-induced) Cardiomyopathy. Unknown status NCT01944826
6 Incidence, Influencing Factors and Outcome of Takotsubo Cardiomyopathy in Patients Suffering From Acute Non-traumatic Subarachnoid Hemorrhage Unknown status NCT02659878
7 Mindfulness-based Sex Therapy on Patients With Takotsubo Cardiomyopathy Among Iranian Women Unknown status NCT03372577
8 Serial Echocardiography After Subarachnoid Hemorrhage (S.E.A.S.) Unknown status NCT00123695
9 Insights in the Pathophysiology of Transient Left Ventricular Ballooning Syndrome (TLVBS) Unknown status NCT01076946
10 Persistent Symptoms and Early Incomplete Recovery After Acute Stress-induced Cardiomyopathy: Is There Ongoing Heart Distress? The HEROIC Study Completed NCT02989454
11 The Evaluation of the Pathogenesis of Stress-Induced Cardiomyopathy by I-123 MIBG Imaging Completed NCT01432626 I-123 radiolabeled metaiodobenzylguanidine cardiac imaging
12 Stress-induced Vascular Dysfunction: Evaluation of Endothelial Function in a Cohort of Patients With Takotsubo Syndrome Completed NCT01249599
13 Pathogenesis of Acute Stress Induced (Tako-tsubo) Cardiomyopathy: Energy Shut-Down or Intense Inflammation? The TERRIFIC Study Completed NCT02897739
14 Genetic Polymorphisms in Catecholamine Pathway Responsible for the Tako-TSUBO Cardiomyopathy Susceptibly (TAKO-GENE) Completed NCT01520610
15 French Observatory Syndromes Tako-Tsubo Completed NCT01252004
16 Personality Profile of Patients With Apical Ballooning Syndrome (ABS) Completed NCT01885975
17 Tako-Tsubo Cardiomyopathy and Cardiac Syndrome X: a Study on the Brain-heart Interactions in Two Orphan Cardiac Diseases. Completed NCT02759341
18 Tako-Tsubo Cardiomyopathy and Cardiac Syndrome X: New Insights Into the Pathophysiology of Two Orphan Cardiac Diseases Completed NCT02307214
19 The Relationship Between the Response to Mental Stress and Vascular Endothelial Function Completed NCT00975559
20 Cardiac Sympathetic Activity in Patients With the Apical Ballooning Syndrome Completed NCT00586183
21 Left Ventricular Dysfunction in Critically Ill Patients Completed NCT03787810
22 Pilot Study: Central Nervous System and Hormonal Changes In Takotsubo Cardiomyopathy Completed NCT02240056
23 The Brain Heart Interaction in Acute Stroke Completed NCT02734082
24 Early Insurgence of Coronary Artery Dysfunction in Prediabetic Patients With Monovessel Non Obstructive Coronary Stenosis May Condition Major Adverse Cardiac Events at 24 Months of Follow up. Completed NCT03553030
25 Stockholm Myocardial Infarction With Normal Coronaries (SMINC)-2 Completed NCT02318498
26 NYU Takotsubo (Broken Heart Syndrome) Registry Recruiting NCT03663348
27 International Multicenter Registry on Takotsubo Cardiomyopathy Recruiting NCT01947621
28 Retrospective and Prospective Observational Study on Cardiological and Oncological Psychosomatics Recruiting NCT03437642
29 Establishing the Incidence of Tako-tsubo Cardiomyopathy in Scotland - the STARR Study Recruiting NCT03299569
30 Optimized Characterization of Takotsubo Syndrome by Obtaining Pressure Volume Loops Recruiting NCT03726528
31 The GErman Italian Spanish Takotsubo (GEIST) Registry Recruiting NCT04361994
32 To Evaluate the Role of Plasma Catecholamine Levels in Predicting the Development of Myocardial Depression in Acute Neurological Patients Recruiting NCT03801694
33 Detection of Myocardial Dysfunction in Non-severe Subarachnoid Hemorrhage (WFNS 1-2) Using Speckle-tracking Echocardiography (STRAIN) Recruiting NCT03761654
34 Etiology of Myocardial Injury Following Non-cardiac Surgery - a Prospective Clinical Trial Recruiting NCT03317561
35 Smidt Heart Institute Takotsubo Registry Recruiting NCT03910569
36 Essential Arterial Hypotension and Allostasis Registry Recruiting NCT02018497
37 Early Cardiac Magnetic Resonance Imaging in Suspected Non-ST-Elevation Myocardial Infarction: An Observational Two-Center Study Recruiting NCT04140019
38 Physical Exercise and Mental Wellbeing Rehabilitation for Acute Stress-induced Takotsubo Cardiomyopathy: The PLEASE Study Active, not recruiting NCT04425785
39 Canadian Spontaneous Coronary Artery Dissection (SCAD) Cohort Study Active, not recruiting NCT02188069
40 IMPact of Donor Heart Function on Recipient Outcomes - a prospectiVE Study to Increase the Utilization of Donor HEARTs Not yet recruiting NCT04393181
41 Autonomic Modulation in Takotsubo Syndrome Not yet recruiting NCT03324529
42 Heterogeneity and Predictors of Stress Reactivity in Takotsubo Syndrome Not yet recruiting NCT04325321
43 E-health Treatment in Stockholm Myocardial Infarction With None-obstructive Coronaries Study Not yet recruiting NCT04178434
44 Thrombosis Risk Assessment May Predict Clinical Presentation and Length of Hospital Stay in Covid-19 Pneumonia Not yet recruiting NCT04423315
45 Multi-modality Imaging & Immunophenotyping of COVID-19 Related Myocardial Injury Not yet recruiting NCT04412369
46 Characterization of Sympathetic Nerve Activity in Stress Cardiomyopathy Terminated NCT01048125 The Modified Oxford Technique for Baroreflex Sensitivity

Search NIH Clinical Center for Broken Heart Syndrome

Genetic Tests for Broken Heart Syndrome

Anatomical Context for Broken Heart Syndrome

MalaCards organs/tissues related to Broken Heart Syndrome:

40
Heart, Brain, Liver, Lung, Endothelial, Testes, Kidney

Publications for Broken Heart Syndrome

Articles related to Broken Heart Syndrome:

(show top 50) (show all 2313)
# Title Authors PMID Year
1
Cardiac arrhythmias associated with Takotsubo cardiomyopathy and ST- segment Elevation Myocardial Infarction (STEMI). 61
32409157 2020
2
Takotsubo Cardiomyopathy presenting with different morphological patterns in the same patient: a case report and review of the literature. 61
32169829 2020
3
[T-wave inversion in the precordial leads: сardiac and non-cardiac causes]. 61
32515715 2020
4
Corrigendum to "Frequency of takotsubo cardiomyopathy in epilepsy-related hospitalizations among adults and its impact on in-hospital outcomes: A national standpoint" [Int. J. Cardiol. 299 (2020): 67-70]. 61
32223961 2020
5
Takotsubo cardiomyopathy triggered by SARS-CoV-2 infection in a critically ill patient. 61
32540884 2020
6
The assessment of coronary microvascular dysfunction: An integral part of risk-stratification in Takotsubo cardiomyopathy. 61
32540215 2020
7
Authors' Response: The three faces of takotsubo cardiomyopathy in a single patient. 61
32535929 2020
8
Racial differences in takotsubo cardiomyopathy outcomes in a large nationwide sample. 61
32147963 2020
9
Takotsubo Cardiomyopathy in an Alzheimer Disease Patient: The Potential Contribution of Antidepressant Agents. 61
32520737 2020
10
Newer Insights Into Takotsubo Cardiomyopathy. 61
31982085 2020
11
Takotsubo Cardiomyopathy in Myasthenic Crisis. 61
32453102 2020
12
"Hidden" takotsubo cardiomyopathy in cardiac care unit. 61
31834614 2020
13
Takotsubo Cardiomyopathy in Males with Covid-19. 61
32517962 2020
14
Recurrent Takotsubo Cardiomyopathy: Getting to the Root of the Problem. 61
32507847 2020
15
Takotsubo cardiomyopathy triggered by delirium tremens in a cirrhotic patient with acute-on-chronic liver failure: A case report. 61
31928968 2020
16
Demarcation of Transient Regional Myocardial Edema in Endocrinopathy-Induced Takotsubo Cardiomyopathy on Cardiac Magnetic Resonance T1 Mapping. 61
32387469 2020
17
Microvascular Disease and Small-Vessel Disease: The Nexus of Multiple Diseases of Women. 61
32074468 2020
18
Global evaluation of echocardiography in patients with COVID-19. 61
32556199 2020
19
High-Resolution Late Gadolinium Enhancement Magnetic Resonance for the Diagnosis of Myocardial Infarction With Nonobstructed Coronary Arteries. 61
31954658 2020
20
Takotsubo cardiomyopathy and pituitary apoplexy: a case report. 61
32429846 2020
21
An Early Holiday Surprise: Cholecystitis Wrapped in Takotsubo Cardiomyopathy. 61
32426655 2020
22
Takotsubo Cardiomyopathy in a Rural Australian Population: Preliminary Observations. 61
31839363 2020
23
Regadenoson Cardiac Stress Test-Induced Takotsubo Cardiomyopathy: A Case Report. 61
32528746 2020
24
Clinical features differentiating Takotsubo cardiomyopathy in the peripartum period from peripartum cardiomyopathy. 61
31705186 2020
25
Stress cardiomyopathy associated with area postrema syndrome as a presentation of neuromyelitis optica: case report. 61
32438902 2020
26
A case of Takotsubo cardiomyopathy with COVID 19. 61
32395765 2020
27
Takotsubo Syndrome in the Setting of COVID-19 Infection. 61
32363351 2020
28
[Antagonistic function of the heart muscle : Part II: Clinical implications]. 61
30054715 2020
29
A case of takotsubo cardiomyopathy developing ventricular fibrillation after a pacemaker implantation. 61
32256864 2020
30
Takotsubo cardiomyopathy as a consequence of 4-fluoroamphetamine Mono-intoxication documented by toxicological analyses. 61
32326765 2020
31
Perioperative Takotsubo Cardiomyopathy (Broken Heart Syndrome)-A Diagnostic Dilemma. 61
32367995 2020
32
Recurrent takotsubo cardiomyopathy: Further insights into morphological patterns. 61
32460038 2020
33
Takotsubo (stress) cardiomyopathy in childhood. 61
31865427 2020
34
Cardiac Tamponade Secondary to COVID-19. 61
32328588 2020
35
Electrocardiographic changes in the differentiation of ischemic and non-ischemic ST elevation. 61
31885293 2020
36
Geriatric oncologists should be aware of cardio-oncology: Impact of age and gender on 5-FU-mediated TakoTsubo cardiomyopathy. 61
32280034 2020
37
The Chicken or the Egg? An Interesting Case Presentation of Spontaneous Coronary Artery Dissection Versus Takotsubo Cardiomyopathy. 61
32455088 2020
38
Left ventricular mechanics in the acute phase of Takotsubo cardiomyopathy: distinctive ballooning patterns translate into different diastolic properties. 61
31560110 2020
39
Diagnostic Accuracy Of The Electrocardiographic Decision Support - Myocardial Ischaemia (EDS-MI) Algorithm In Detection Of Acute Coronary Occlusion. 61
29611430 2020
40
Takotsubo cardiomyopathy: Review of broken heart syndrome. 61
32039951 2020
41
Phaeochromocytoma presenting as Takotsubo cardiomyopathy. 61
32188661 2020
42
Takotsubo Cardiomyopathy after Elective Aortic and Mitral Valve Replacement. 61
32337907 2020
43
Mid-Cavity Variant Takotsubo Cardiomyopathy-Magnetic Resonance Imaging Findings. 61
29754861 2020
44
Biomarkers in patients with Takotsubo cardiomyopathy compared to patients with acute anterior ST-elevation myocardial infarction. 61
31902247 2020
45
Stress (Takotsubo) Cardiomyopathy; A Review of its Pathophysiology, Manifestations, and Factors that Affect Prognosis. 61
32282392 2020
46
Concominant hypertrophic and takotsubo cardiomyopathy; cardiac magnetic resonance with parametric mapping findings after acute phase. 61
31760511 2020
47
Reverse Takotsubo Cardiomyopathy After Caesarean Section With Epidural Anesthesia: Initial Assessment and Follow-up. 61
31732378 2020
48
Percutaneous Catheter Thrombus Aspiration of Right Renal Infarction Caused by Left Ventricular Thrombi due to Takotsubo Cardiomyopathy. 61
32173705 2020
49
Scorpion envenomation: state of the art. 61
32125457 2020
50
Acute Coronary Syndrome: Common Complications and Conditions That Mimic ACS. 61
32150366 2020

Variations for Broken Heart Syndrome

Expression for Broken Heart Syndrome

Search GEO for disease gene expression data for Broken Heart Syndrome.

Pathways for Broken Heart Syndrome

GO Terms for Broken Heart Syndrome

Sources for Broken Heart Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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