MCID: BRN137
MIFTS: 27

Bronchial Neuroendocrine Tumor

Categories: Endocrine diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Bronchial Neuroendocrine Tumor

Summaries for Bronchial Neuroendocrine Tumor

MalaCards based summary : Bronchial Neuroendocrine Tumor, also known as bronchial net, is related to neuroendocrine tumor and conn's syndrome. An important gene associated with Bronchial Neuroendocrine Tumor is AVPR1B (Arginine Vasopressin Receptor 1B). Affiliated tissues include lung, trachea and liver, and related phenotypes are pulmonary carcinoid tumor and dyspnea

Related Diseases for Bronchial Neuroendocrine Tumor

Diseases related to Bronchial Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 10.3
2 conn's syndrome 9.9
3 acromegaly 9.9

Symptoms & Phenotypes for Bronchial Neuroendocrine Tumor

Human phenotypes related to Bronchial Neuroendocrine Tumor:

60 33 (show all 31)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pulmonary carcinoid tumor 60 33 obligate (100%) Obligate (100%) HP:0030445
2 dyspnea 60 33 frequent (33%) Frequent (79-30%) HP:0002094
3 weight loss 60 33 frequent (33%) Frequent (79-30%) HP:0001824
4 anorexia 60 33 frequent (33%) Frequent (79-30%) HP:0002039
5 hemoptysis 60 33 frequent (33%) Frequent (79-30%) HP:0002105
6 asthma 60 33 frequent (33%) Frequent (79-30%) HP:0002099
7 chest pain 60 33 frequent (33%) Frequent (79-30%) HP:0100749
8 pneumonia 60 33 frequent (33%) Frequent (79-30%) HP:0002090
9 interstitial pulmonary abnormality 60 33 frequent (33%) Frequent (79-30%) HP:0006530
10 poor appetite 60 33 frequent (33%) Frequent (79-30%) HP:0004396
11 chronic noninfectious lymphadenopathy 60 33 frequent (33%) Frequent (79-30%) HP:0002730
12 wheezing 60 33 frequent (33%) Frequent (79-30%) HP:0030828
13 nonproductive cough 60 33 frequent (33%) Frequent (79-30%) HP:0031246
14 hypotension 60 33 very rare (1%) Very rare (<4-1%) HP:0002615
15 hepatomegaly 60 33 very rare (1%) Very rare (<4-1%) HP:0002240
16 hepatic failure 60 33 very rare (1%) Very rare (<4-1%) HP:0001399
17 growth hormone excess 60 33 very rare (1%) Very rare (<4-1%) HP:0000845
18 increased circulating acth level 60 33 very rare (1%) Very rare (<4-1%) HP:0003154
19 tricuspid regurgitation 60 33 very rare (1%) Very rare (<4-1%) HP:0005180
20 increased circulating cortisol level 60 33 very rare (1%) Very rare (<4-1%) HP:0003118
21 night sweats 60 33 very rare (1%) Very rare (<4-1%) HP:0030166
22 palpitations 60 33 very rare (1%) Very rare (<4-1%) HP:0001962
23 cardiogenic shock 60 33 very rare (1%) Very rare (<4-1%) HP:0030149
24 increased serum serotonin 60 33 very rare (1%) Very rare (<4-1%) HP:0003144
25 protracted diarrhea 60 33 very rare (1%) Very rare (<4-1%) HP:0004385
26 right ventricular failure 60 33 very rare (1%) Very rare (<4-1%) HP:0001708
27 dermatological manifestations of systemic disorders 60 33 very rare (1%) Very rare (<4-1%) HP:0001005
28 facial telangiectasia 60 33 very rare (1%) Very rare (<4-1%) HP:0007380
29 bowel urgency 60 33 very rare (1%) Very rare (<4-1%) HP:0012701
30 bronchospasm 60 33 very rare (1%) Very rare (<4-1%) HP:0025428
31 abnormal pulmonary valve cusp morphology 60 33 very rare (1%) Very rare (<4-1%) HP:0031566

MGI Mouse Phenotypes related to Bronchial Neuroendocrine Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.13 AVPR1B GHRL RLN1
2 endocrine/exocrine gland MP:0005379 8.8 AVPR1B GHRL RLN1

Drugs & Therapeutics for Bronchial Neuroendocrine Tumor

Search Clinical Trials , NIH Clinical Center for Bronchial Neuroendocrine Tumor

Genetic Tests for Bronchial Neuroendocrine Tumor

Anatomical Context for Bronchial Neuroendocrine Tumor

MalaCards organs/tissues related to Bronchial Neuroendocrine Tumor:

42
Lung, Trachea, Liver, Pineal

Publications for Bronchial Neuroendocrine Tumor

Articles related to Bronchial Neuroendocrine Tumor:

# Title Authors Year
1
Management and Follow-up of Patients with a Bronchial Neuroendocrine Tumor in the Last Twenty Years in Ireland: Expected Inconsistencies and Unexpected Discoveries. ( 30228817 )
2018
2
Metastatic bronchial neuroendocrine tumor to the pineal gland: a unique manifestation of a rare disease. ( 20363727 )
2010
3
Carcinoid crisis induced by receptor radionuclide therapy with 90Y-DOTATOC in a case of liver metastases from bronchial neuroendocrine tumor (atypical carcinoid). ( 16840837 )
2006
4
[Five year remission of GHRH secreting bronchial neuroendocrine tumor with symptoms of acromegaly. Utility of chromogranin A in the monitoring of the disease]. ( 16575760 )
2006
5
Cyclical Cushing's syndrome in a patient with a bronchial neuroendocrine tumor (typical carcinoid) expressing ghrelin and growth hormone secretagogue receptors. ( 14671177 )
2003

Variations for Bronchial Neuroendocrine Tumor

Expression for Bronchial Neuroendocrine Tumor

Search GEO for disease gene expression data for Bronchial Neuroendocrine Tumor.

Pathways for Bronchial Neuroendocrine Tumor

GO Terms for Bronchial Neuroendocrine Tumor

Biological processes related to Bronchial Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 8.96 GHRL RLN1
2 positive regulation of cytosolic calcium ion concentration GO:0007204 8.62 AVPR1B GHRL

Molecular functions related to Bronchial Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 GHRL RLN1

Sources for Bronchial Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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