MCID: BRN137
MIFTS: 30

Bronchial Neuroendocrine Tumor

Categories: Endocrine diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Bronchial Neuroendocrine Tumor

Summaries for Bronchial Neuroendocrine Tumor

MalaCards based summary : Bronchial Neuroendocrine Tumor, also known as bronchial net, is related to neuroendocrine tumor and conn's syndrome. An important gene associated with Bronchial Neuroendocrine Tumor is GHRL (Ghrelin And Obestatin Prepropeptide). Affiliated tissues include lung, trachea and liver, and related phenotypes are pulmonary carcinoid tumor and dyspnea

Related Diseases for Bronchial Neuroendocrine Tumor

Diseases related to Bronchial Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 10.2
2 conn's syndrome 9.9
3 acromegaly 9.9

Symptoms & Phenotypes for Bronchial Neuroendocrine Tumor

Human phenotypes related to Bronchial Neuroendocrine Tumor:

60 33 (show all 31)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pulmonary carcinoid tumor 60 33 obligate (100%) Obligate (100%) HP:0030445
2 dyspnea 60 33 frequent (33%) Frequent (79-30%) HP:0002094
3 weight loss 60 33 frequent (33%) Frequent (79-30%) HP:0001824
4 anorexia 60 33 frequent (33%) Frequent (79-30%) HP:0002039
5 hemoptysis 60 33 frequent (33%) Frequent (79-30%) HP:0002105
6 asthma 60 33 frequent (33%) Frequent (79-30%) HP:0002099
7 chest pain 60 33 frequent (33%) Frequent (79-30%) HP:0100749
8 pneumonia 60 33 frequent (33%) Frequent (79-30%) HP:0002090
9 interstitial pulmonary abnormality 60 33 frequent (33%) Frequent (79-30%) HP:0006530
10 poor appetite 60 33 frequent (33%) Frequent (79-30%) HP:0004396
11 chronic noninfectious lymphadenopathy 60 33 frequent (33%) Frequent (79-30%) HP:0002730
12 wheezing 60 33 frequent (33%) Frequent (79-30%) HP:0030828
13 nonproductive cough 60 33 frequent (33%) Frequent (79-30%) HP:0031246
14 hypotension 60 33 very rare (1%) Very rare (<4-1%) HP:0002615
15 hepatomegaly 60 33 very rare (1%) Very rare (<4-1%) HP:0002240
16 growth hormone excess 60 33 very rare (1%) Very rare (<4-1%) HP:0000845
17 hepatic failure 60 33 very rare (1%) Very rare (<4-1%) HP:0001399
18 increased circulating acth level 60 33 very rare (1%) Very rare (<4-1%) HP:0003154
19 tricuspid regurgitation 60 33 very rare (1%) Very rare (<4-1%) HP:0005180
20 increased circulating cortisol level 60 33 very rare (1%) Very rare (<4-1%) HP:0003118
21 night sweats 60 33 very rare (1%) Very rare (<4-1%) HP:0030166
22 palpitations 60 33 very rare (1%) Very rare (<4-1%) HP:0001962
23 cardiogenic shock 60 33 very rare (1%) Very rare (<4-1%) HP:0030149
24 right ventricular failure 60 33 very rare (1%) Very rare (<4-1%) HP:0001708
25 dermatological manifestations of systemic disorders 60 33 very rare (1%) Very rare (<4-1%) HP:0001005
26 facial telangiectasia 60 33 very rare (1%) Very rare (<4-1%) HP:0007380
27 increased serum serotonin 60 33 very rare (1%) Very rare (<4-1%) HP:0003144
28 protracted diarrhea 60 33 very rare (1%) Very rare (<4-1%) HP:0004385
29 bowel urgency 60 33 very rare (1%) Very rare (<4-1%) HP:0012701
30 bronchospasm 60 33 very rare (1%) Very rare (<4-1%) HP:0025428
31 abnormal pulmonary valve cusp morphology 60 33 very rare (1%) Very rare (<4-1%) HP:0031566

MGI Mouse Phenotypes related to Bronchial Neuroendocrine Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.13 AVPR1B GHRL RLN1
2 endocrine/exocrine gland MP:0005379 8.8 AVPR1B GHRL RLN1

Drugs & Therapeutics for Bronchial Neuroendocrine Tumor

Search Clinical Trials , NIH Clinical Center for Bronchial Neuroendocrine Tumor

Genetic Tests for Bronchial Neuroendocrine Tumor

Anatomical Context for Bronchial Neuroendocrine Tumor

MalaCards organs/tissues related to Bronchial Neuroendocrine Tumor:

42
Lung, Trachea, Liver, Skeletal Muscle, Pineal

Publications for Bronchial Neuroendocrine Tumor

Articles related to Bronchial Neuroendocrine Tumor:

(show all 28)
# Title Authors Year
1
Management and Follow-up of Patients with a Bronchial Neuroendocrine Tumor in the Last Twenty Years in Ireland: Expected Inconsistencies and Unexpected Discoveries. ( 30228817 )
2018
2
Anesthesia management of a newborn with Pena-Shokeir Syndrome. ( 29291469 )
2018
3
Autistic-Like Traits in Pena-Shokeir Syndrome. ( 30430318 )
2018
4
Pena-Shokeir syndrome: current management strategies and palliative care. ( 30498368 )
2018
5
Otopathologic Findings of Pena-Shokeir Syndrome Type I. ( 27067155 )
2016
6
Prenatal Diagnosis of Arthrogryposis as a Phenotype of Pena-Shokeir Syndrome using Two- and Three-dimensional Ultrasonography. ( 24987567 )
2014
7
Anaesthesia and orphan disease: anaesthetic management of a child with Pena-Shokeir syndrome. ( 22692041 )
2012
8
Antenatal ultrasound and MRI findings of Pena-Shokeir syndrome. ( 20938779 )
2011
9
Metastatic bronchial neuroendocrine tumor to the pineal gland: a unique manifestation of a rare disease. ( 20363727 )
2010
10
Prenatal diagnosis of Pena-Shokeir syndrome phenotype by ultrasonography and MR imaging. ( 19194699 )
2009
11
Tonic-clonic seizures in a fetus with Pena-Shokeir syndrome. ( 19643800 )
2009
12
Carcinoid crisis induced by receptor radionuclide therapy with 90Y-DOTATOC in a case of liver metastases from bronchial neuroendocrine tumor (atypical carcinoid). ( 16840837 )
2006
13
[Five year remission of GHRH secreting bronchial neuroendocrine tumor with symptoms of acromegaly. Utility of chromogranin A in the monitoring of the disease]. ( 16575760 )
2006
14
Acute respiratory distress in Pena-Shokeir syndrome. ( 15628635 )
2004
15
Cyclical Cushing's syndrome in a patient with a bronchial neuroendocrine tumor (typical carcinoid) expressing ghrelin and growth hormone secretagogue receptors. ( 14671177 )
2003
16
An autopsy case of Pena-Shokeir syndrome: severe retardation of skeletal muscle development compared with neuronal abnormalities. ( 12396902 )
2002
17
Prenatal sonographic diagnosis of Pena-Shokeir syndrome type I. ( 11422985 )
2001
18
Association of Shokeir syndrome (congenital universal alopecia, epilepsy, mental subnormality and pyorrhea) and giant pigmented nevus. ( 8275563 )
1993
19
Absent fetal movement response with a blunted cardioacceleratory fetal response to external vibratory acoustic stimulation in a fetus with the Pena-Shokeir syndrome (fetal akinesia and hypokinesia sequence). ( 1550625 )
1992
20
A dominant-hereditary variation of the Pena-Shokeir syndrome; a case report. ( 2070954 )
1991
21
Antenatal diagnosis of Pena-Shokeir syndrome (type I) with ultrasonography and magnetic resonance imaging. ( 3043297 )
1988
22
Pena-Shokeir syndrome. Prenatal diagnosis by ultrasonography. ( 3316696 )
1987
23
The heterogeneity of the Pena-Shokeir syndrome. ( 3561707 )
1987
24
Disturbances in neuronal migration and laminar cortical organization associated with multicystic encephalopathy in the Pena-Shokeir syndrome. ( 3754373 )
1986
25
Syndrome of camptodactyly, ankyloses, facial anomalies, and pulmonary hypoplasia (Pena-Shokeir syndrome): obstetric and ultrasound aspects. ( 3890548 )
1985
26
The Pena-Shokeir syndrome: report of nine Dutch cases. ( 3895932 )
1985
27
Pena-Shokeir syndrome I (report of a case). ( 4004668 )
1985
28
The Pena-Shokeir syndrome: report of five cases and further delineation of the syndrome. ( 6650566 )
1983

Variations for Bronchial Neuroendocrine Tumor

Expression for Bronchial Neuroendocrine Tumor

Search GEO for disease gene expression data for Bronchial Neuroendocrine Tumor.

Pathways for Bronchial Neuroendocrine Tumor

GO Terms for Bronchial Neuroendocrine Tumor

Biological processes related to Bronchial Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 8.96 GHRL RLN1
2 positive regulation of cytosolic calcium ion concentration GO:0007204 8.62 AVPR1B GHRL

Molecular functions related to Bronchial Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 GHRL RLN1

Sources for Bronchial Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
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32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
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38 KEGG
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45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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