MCID: BRN137
MIFTS: 29

Bronchial Neuroendocrine Tumor

Categories: Endocrine diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Bronchial Neuroendocrine Tumor

Summaries for Bronchial Neuroendocrine Tumor

MalaCards based summary : Bronchial Neuroendocrine Tumor, also known as bronchial net, is related to conn's syndrome and neuroendocrine tumor. An important gene associated with Bronchial Neuroendocrine Tumor is AVPR1B (Arginine Vasopressin Receptor 1B), and among its related pathways/superpathways are Peptide ligand-binding receptors and Relaxin signaling pathway. The drugs Somatostatin and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include lung, trachea and pineal, and related phenotypes are pulmonary carcinoid tumor and anorexia

Related Diseases for Bronchial Neuroendocrine Tumor

Diseases related to Bronchial Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 conn's syndrome 29.3 GHRL AVPR1B
2 neuroendocrine tumor 10.3
3 carcinoid tumors, intestinal 10.1
4 ectopic cushing syndrome 9.9
5 neuroendocrine carcinoma 9.9
6 acromegaly 9.9
7 pituitary adenoma 9.9
8 hypokalemia 9.9
9 carcinoid syndrome 9.9
10 panic disorder 9.6 GHRL AVPR1B
11 anxiety 9.5 GHRL AVPR1B
12 major depressive disorder 9.4 GHRL AVPR1B

Graphical network of the top 20 diseases related to Bronchial Neuroendocrine Tumor:



Diseases related to Bronchial Neuroendocrine Tumor

Symptoms & Phenotypes for Bronchial Neuroendocrine Tumor

Human phenotypes related to Bronchial Neuroendocrine Tumor:

58 31 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pulmonary carcinoid tumor 58 31 obligate (100%) Obligate (100%) HP:0030445
2 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
3 dyspnea 58 31 frequent (33%) Frequent (79-30%) HP:0002094
4 hemoptysis 58 31 frequent (33%) Frequent (79-30%) HP:0002105
5 asthma 58 31 frequent (33%) Frequent (79-30%) HP:0002099
6 chest pain 58 31 frequent (33%) Frequent (79-30%) HP:0100749
7 weight loss 58 31 frequent (33%) Frequent (79-30%) HP:0001824
8 pneumonia 58 31 frequent (33%) Frequent (79-30%) HP:0002090
9 poor appetite 58 31 frequent (33%) Frequent (79-30%) HP:0004396
10 chronic noninfectious lymphadenopathy 58 31 frequent (33%) Frequent (79-30%) HP:0002730
11 wheezing 58 31 frequent (33%) Frequent (79-30%) HP:0030828
12 nonproductive cough 58 31 frequent (33%) Frequent (79-30%) HP:0031246
13 abnormal pulmonary interstitial morphology 31 frequent (33%) HP:0006530
14 hypotension 58 31 very rare (1%) Very rare (<4-1%) HP:0002615
15 hepatomegaly 58 31 very rare (1%) Very rare (<4-1%) HP:0002240
16 hepatic failure 58 31 very rare (1%) Very rare (<4-1%) HP:0001399
17 growth hormone excess 58 31 very rare (1%) Very rare (<4-1%) HP:0000845
18 tricuspid regurgitation 58 31 very rare (1%) Very rare (<4-1%) HP:0005180
19 facial telangiectasia 58 31 very rare (1%) Very rare (<4-1%) HP:0007380
20 night sweats 58 31 very rare (1%) Very rare (<4-1%) HP:0030166
21 increased circulating acth level 58 31 very rare (1%) Very rare (<4-1%) HP:0003154
22 palpitations 58 31 very rare (1%) Very rare (<4-1%) HP:0001962
23 increased circulating cortisol level 58 31 very rare (1%) Very rare (<4-1%) HP:0003118
24 right ventricular failure 58 31 very rare (1%) Very rare (<4-1%) HP:0001708
25 cardiogenic shock 58 31 very rare (1%) Very rare (<4-1%) HP:0030149
26 increased serum serotonin 58 31 very rare (1%) Very rare (<4-1%) HP:0003144
27 bronchospasm 58 31 very rare (1%) Very rare (<4-1%) HP:0025428
28 dermatological manifestations of systemic disorders 58 31 very rare (1%) Very rare (<4-1%) HP:0001005
29 protracted diarrhea 58 31 very rare (1%) Very rare (<4-1%) HP:0004385
30 bowel urgency 58 31 very rare (1%) Very rare (<4-1%) HP:0012701
31 abnormal pulmonary valve cusp morphology 58 31 very rare (1%) Very rare (<4-1%) HP:0031566
32 interstitial pulmonary abnormality 58 Frequent (79-30%)

MGI Mouse Phenotypes related to Bronchial Neuroendocrine Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 8.8 AVPR1B GHRL RLN1

Drugs & Therapeutics for Bronchial Neuroendocrine Tumor

Drugs for Bronchial Neuroendocrine Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved, Investigational Phase 2 51110-01-1, 38916-34-6 53481605
2
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
3
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030
4 Immunologic Factors Phase 2
5 Immunosuppressive Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Phase II Trial of Lutetium Lu 177 Dotatate Versus Everolimus in Somatostatin Receptor Positive Bronchial Neuroendocrine Tumors Not yet recruiting NCT04665739 Phase 2 Everolimus;Lutetium Lu 177 Dotatate

Search NIH Clinical Center for Bronchial Neuroendocrine Tumor

Genetic Tests for Bronchial Neuroendocrine Tumor

Anatomical Context for Bronchial Neuroendocrine Tumor

MalaCards organs/tissues related to Bronchial Neuroendocrine Tumor:

40
Lung, Trachea, Pineal

Publications for Bronchial Neuroendocrine Tumor

Articles related to Bronchial Neuroendocrine Tumor:

(show all 14)
# Title Authors PMID Year
1
Australian experience of peptide receptor radionuclide therapy in lung neuroendocrine tumours. 61
32676165 2020
2
Salvage peptide receptor radionuclide therapy with [177Lu-DOTA,Tyr3]octreotate in patients with bronchial and gastroenteropancreatic neuroendocrine tumours. 61
30267116 2019
3
Management and Follow-up of Patients with a Bronchial Neuroendocrine Tumor in the Last Twenty Years in Ireland: Expected Inconsistencies and Unexpected Discoveries. 61
30228817 2018
4
¹⁷⁷Lu-Labeled Agents for Neuroendocrine Tumor Therapy and Bone Pain Palliation in Uruguay. 61
25771367 2016
5
Observational study of patients with gastroenteropancreatic and bronchial neuroendocrine tumors in Argentina: Results from the large database of a multidisciplinary group clinical multicenter study. 61
25054030 2014
6
Glucose-dependent insulinotropic polypeptide receptors in most gastroenteropancreatic and bronchial neuroendocrine tumors. 61
22112810 2012
7
Metastatic bronchial neuroendocrine tumor to the pineal gland: a unique manifestation of a rare disease. 61
20363727 2010
8
Stimulatory effect of growth hormone-releasing hormone (GHRH(1-29)NH2) on the proliferation, VEGF and chromogranin A secretion by human neuroendocrine tumor cell line NCI-H727 in vitro. 61
19747727 2009
9
Carcinoid crisis induced by receptor radionuclide therapy with 90Y-DOTATOC in a case of liver metastases from bronchial neuroendocrine tumor (atypical carcinoid). 61
16840837 2006
10
[Five year remission of GHRH secreting bronchial neuroendocrine tumor with symptoms of acromegaly. Utility of chromogranin A in the monitoring of the disease]. 61
16575760 2006
11
Cyclical Cushing's syndrome in a patient with a bronchial neuroendocrine tumor (typical carcinoid) expressing ghrelin and growth hormone secretagogue receptors. 61
14671177 2003
12
Pulmonary neuroendocrine tumors: incidence and prognosis of histological subtypes. A population-based study in Denmark. 61
12140134 2002
13
[Metastatic gastric calcifications and bronchial neuroendocrine tumor]. 61
11924191 2001
14
Bronchial neuroendocrine (carcinoid) tumor causing unilateral left-sided carcinoid heart disease. 61
2013974 1991

Variations for Bronchial Neuroendocrine Tumor

Expression for Bronchial Neuroendocrine Tumor

Search GEO for disease gene expression data for Bronchial Neuroendocrine Tumor.

Pathways for Bronchial Neuroendocrine Tumor

GO Terms for Bronchial Neuroendocrine Tumor

Biological processes related to Bronchial Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 8.96 GHRL AVPR1B
2 positive regulation of cytosolic calcium ion concentration GO:0007204 8.62 GHRL AVPR1B

Molecular functions related to Bronchial Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 RLN1 GHRL

Sources for Bronchial Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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