MCID: BRN137
MIFTS: 31

Bronchial Neuroendocrine Tumor

Categories: Endocrine diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Bronchial Neuroendocrine Tumor

Summaries for Bronchial Neuroendocrine Tumor

MalaCards based summary : Bronchial Neuroendocrine Tumor, also known as bronchial net, is related to conn's syndrome and neuroendocrine tumor. An important gene associated with Bronchial Neuroendocrine Tumor is AVPR1B (Arginine Vasopressin Receptor 1B), and among its related pathways/superpathways are Peptide ligand-binding receptors and Relaxin signaling pathway. The drugs Sirolimus and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include lung, trachea and bone, and related phenotypes are pulmonary carcinoid tumor and dyspnea

Related Diseases for Bronchial Neuroendocrine Tumor

Diseases related to Bronchial Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 16, show less)
# Related Disease Score Top Affiliating Genes
1 conn's syndrome 28.6 GHRL AVPR1B
2 neuroendocrine tumor 10.3
3 carcinoid tumors, intestinal 10.0
4 multiple endocrine neoplasia, type i 10.0
5 multiple endocrine neoplasia 10.0
6 myelodysplastic syndrome 9.9
7 ectopic cushing syndrome 9.9
8 acute leukemia 9.9
9 diarrhea 9.9
10 neuroendocrine carcinoma 9.9
11 constipation 9.9
12 acromegaly 9.9
13 adenocarcinoma 9.9
14 pituitary adenoma 9.9
15 hypokalemia 9.9
16 panic disorder 9.3 GHRL AVPR1B

Graphical network of the top 20 diseases related to Bronchial Neuroendocrine Tumor:



Diseases related to Bronchial Neuroendocrine Tumor

Symptoms & Phenotypes for Bronchial Neuroendocrine Tumor

Human phenotypes related to Bronchial Neuroendocrine Tumor:

58 31 (showing 31, show less)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pulmonary carcinoid tumor 58 31 obligate (100%) Obligate (100%) HP:0030445
2 dyspnea 58 31 frequent (33%) Frequent (79-30%) HP:0002094
3 weight loss 58 31 frequent (33%) Frequent (79-30%) HP:0001824
4 chest pain 58 31 frequent (33%) Frequent (79-30%) HP:0100749
5 anorexia 58 31 frequent (33%) Frequent (79-30%) HP:0002039
6 hemoptysis 58 31 frequent (33%) Frequent (79-30%) HP:0002105
7 asthma 58 31 frequent (33%) Frequent (79-30%) HP:0002099
8 pneumonia 58 31 frequent (33%) Frequent (79-30%) HP:0002090
9 interstitial pulmonary abnormality 58 31 frequent (33%) Frequent (79-30%) HP:0006530
10 wheezing 58 31 frequent (33%) Frequent (79-30%) HP:0030828
11 poor appetite 58 31 frequent (33%) Frequent (79-30%) HP:0004396
12 chronic noninfectious lymphadenopathy 58 31 frequent (33%) Frequent (79-30%) HP:0002730
13 nonproductive cough 58 31 frequent (33%) Frequent (79-30%) HP:0031246
14 hypotension 58 31 very rare (1%) Very rare (<4-1%) HP:0002615
15 hepatomegaly 58 31 very rare (1%) Very rare (<4-1%) HP:0002240
16 hepatic failure 58 31 very rare (1%) Very rare (<4-1%) HP:0001399
17 growth hormone excess 58 31 very rare (1%) Very rare (<4-1%) HP:0000845
18 protracted diarrhea 58 31 very rare (1%) Very rare (<4-1%) HP:0004385
19 increased circulating acth level 58 31 very rare (1%) Very rare (<4-1%) HP:0003154
20 facial telangiectasia 58 31 very rare (1%) Very rare (<4-1%) HP:0007380
21 increased serum serotonin 58 31 very rare (1%) Very rare (<4-1%) HP:0003144
22 tricuspid regurgitation 58 31 very rare (1%) Very rare (<4-1%) HP:0005180
23 increased circulating cortisol level 58 31 very rare (1%) Very rare (<4-1%) HP:0003118
24 palpitations 58 31 very rare (1%) Very rare (<4-1%) HP:0001962
25 night sweats 58 31 very rare (1%) Very rare (<4-1%) HP:0030166
26 cardiogenic shock 58 31 very rare (1%) Very rare (<4-1%) HP:0030149
27 right ventricular failure 58 31 very rare (1%) Very rare (<4-1%) HP:0001708
28 dermatological manifestations of systemic disorders 58 31 very rare (1%) Very rare (<4-1%) HP:0001005
29 bronchospasm 58 31 very rare (1%) Very rare (<4-1%) HP:0025428
30 bowel urgency 58 31 very rare (1%) Very rare (<4-1%) HP:0012701
31 abnormal pulmonary valve cusp morphology 58 31 very rare (1%) Very rare (<4-1%) HP:0031566

MGI Mouse Phenotypes related to Bronchial Neuroendocrine Tumor:

45 (showing 1, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 8.8 AVPR1B GHRL RLN1

Drugs & Therapeutics for Bronchial Neuroendocrine Tumor

Drugs for Bronchial Neuroendocrine Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 9, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
2
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
3
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
4 Anti-Infective Agents Phase 2
5 Antibiotics, Antitubercular Phase 2
6 Antifungal Agents Phase 2
7 Anti-Bacterial Agents Phase 2
8 Immunosuppressive Agents Phase 2
9 Immunologic Factors Phase 2

Interventional clinical trials:

(showing 1, show less)
# Name Status NCT ID Phase Drugs
1 Safety and Tolerability of Everolimus as Second-line Treatment in Poorly Differentiated Neuroendocrine Carcinoma / Neuroendocrine Carcinoma G3 (WHO 2010) and Neuroendocrine Tumor G3 - an Investigator Initiated Phase II Study Recruiting NCT02113800 Phase 2 Everolimus (Afinitor®)

Search NIH Clinical Center for Bronchial Neuroendocrine Tumor

Genetic Tests for Bronchial Neuroendocrine Tumor

Anatomical Context for Bronchial Neuroendocrine Tumor

MalaCards organs/tissues related to Bronchial Neuroendocrine Tumor:

40
Lung, Trachea, Bone, Heart, Liver, Pineal, Pituitary

Publications for Bronchial Neuroendocrine Tumor

Articles related to Bronchial Neuroendocrine Tumor:

(showing 13, show less)
# Title Authors PMID Year
1
Salvage peptide receptor radionuclide therapy with [177Lu-DOTA,Tyr3]octreotate in patients with bronchial and gastroenteropancreatic neuroendocrine tumours. 61
30267116 2019
2
Management and Follow-up of Patients with a Bronchial Neuroendocrine Tumor in the Last Twenty Years in Ireland: Expected Inconsistencies and Unexpected Discoveries. 61
30228817 2018
3
¹⁷⁷Lu-Labeled Agents for Neuroendocrine Tumor Therapy and Bone Pain Palliation in Uruguay. 61
25771367 2016
4
Observational study of patients with gastroenteropancreatic and bronchial neuroendocrine tumors in Argentina: Results from the large database of a multidisciplinary group clinical multicenter study. 61
25054030 2014
5
Glucose-dependent insulinotropic polypeptide receptors in most gastroenteropancreatic and bronchial neuroendocrine tumors. 61
22112810 2012
6
Metastatic bronchial neuroendocrine tumor to the pineal gland: a unique manifestation of a rare disease. 61
20363727 2010
7
Stimulatory effect of growth hormone-releasing hormone (GHRH(1-29)NH2) on the proliferation, VEGF and chromogranin A secretion by human neuroendocrine tumor cell line NCI-H727 in vitro. 61
19747727 2009
8
Carcinoid crisis induced by receptor radionuclide therapy with 90Y-DOTATOC in a case of liver metastases from bronchial neuroendocrine tumor (atypical carcinoid). 61
16840837 2006
9
[Five year remission of GHRH secreting bronchial neuroendocrine tumor with symptoms of acromegaly. Utility of chromogranin A in the monitoring of the disease]. 61
16575760 2006
10
Cyclical Cushing's syndrome in a patient with a bronchial neuroendocrine tumor (typical carcinoid) expressing ghrelin and growth hormone secretagogue receptors. 61
14671177 2003
11
Pulmonary neuroendocrine tumors: incidence and prognosis of histological subtypes. A population-based study in Denmark. 61
12140134 2002
12
[Metastatic gastric calcifications and bronchial neuroendocrine tumor]. 61
11924191 2001
13
Bronchial neuroendocrine (carcinoid) tumor causing unilateral left-sided carcinoid heart disease. 61
2013974 1991

Variations for Bronchial Neuroendocrine Tumor

Expression for Bronchial Neuroendocrine Tumor

Search GEO for disease gene expression data for Bronchial Neuroendocrine Tumor.

Pathways for Bronchial Neuroendocrine Tumor

GO Terms for Bronchial Neuroendocrine Tumor

Biological processes related to Bronchial Neuroendocrine Tumor according to GeneCards Suite gene sharing:

(showing 2, show less)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.13 RLN1 GHRL AVPR1B
2 positive regulation of cytosolic calcium ion concentration GO:0007204 8.62 GHRL AVPR1B

Molecular functions related to Bronchial Neuroendocrine Tumor according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 RLN1 GHRL

Sources for Bronchial Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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