MCID: BRN137
MIFTS: 28

Bronchial Neuroendocrine Tumor

Categories: Endocrine diseases, Neuronal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Bronchial Neuroendocrine Tumor

Summaries for Bronchial Neuroendocrine Tumor

MalaCards based summary : Bronchial Neuroendocrine Tumor, also known as bronchial net, is related to neuroendocrine tumor and carcinoid tumors, intestinal. An important gene associated with Bronchial Neuroendocrine Tumor is AVPR1B (Arginine Vasopressin Receptor 1B). The drugs Sirolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, trachea and liver, and related phenotypes are pulmonary carcinoid tumor and dyspnea

Related Diseases for Bronchial Neuroendocrine Tumor

Diseases related to Bronchial Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 15, show less)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 10.3
2 carcinoid tumors, intestinal 10.0
3 multiple endocrine neoplasia, type i 10.0
4 multiple endocrine neoplasia 10.0
5 myelodysplastic syndrome 9.9
6 ectopic cushing syndrome 9.9
7 conn's syndrome 9.9
8 acute leukemia 9.9
9 diarrhea 9.9
10 neuroendocrine carcinoma 9.9
11 constipation 9.9
12 acromegaly 9.9
13 adenocarcinoma 9.9
14 pituitary adenoma 9.9
15 hypokalemia 9.9

Graphical network of the top 20 diseases related to Bronchial Neuroendocrine Tumor:



Diseases related to Bronchial Neuroendocrine Tumor

Symptoms & Phenotypes for Bronchial Neuroendocrine Tumor

Human phenotypes related to Bronchial Neuroendocrine Tumor:

59 32 (showing 31, show less)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pulmonary carcinoid tumor 59 32 obligate (100%) Obligate (100%) HP:0030445
2 dyspnea 59 32 frequent (33%) Frequent (79-30%) HP:0002094
3 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
4 chest pain 59 32 frequent (33%) Frequent (79-30%) HP:0100749
5 anorexia 59 32 frequent (33%) Frequent (79-30%) HP:0002039
6 hemoptysis 59 32 frequent (33%) Frequent (79-30%) HP:0002105
7 asthma 59 32 frequent (33%) Frequent (79-30%) HP:0002099
8 pneumonia 59 32 frequent (33%) Frequent (79-30%) HP:0002090
9 interstitial pulmonary abnormality 59 32 frequent (33%) Frequent (79-30%) HP:0006530
10 poor appetite 59 32 frequent (33%) Frequent (79-30%) HP:0004396
11 wheezing 59 32 frequent (33%) Frequent (79-30%) HP:0030828
12 chronic noninfectious lymphadenopathy 59 32 frequent (33%) Frequent (79-30%) HP:0002730
13 nonproductive cough 59 32 frequent (33%) Frequent (79-30%) HP:0031246
14 hypotension 59 32 very rare (1%) Very rare (<4-1%) HP:0002615
15 hepatomegaly 59 32 very rare (1%) Very rare (<4-1%) HP:0002240
16 hepatic failure 59 32 very rare (1%) Very rare (<4-1%) HP:0001399
17 growth hormone excess 59 32 very rare (1%) Very rare (<4-1%) HP:0000845
18 increased circulating acth level 59 32 very rare (1%) Very rare (<4-1%) HP:0003154
19 facial telangiectasia 59 32 very rare (1%) Very rare (<4-1%) HP:0007380
20 increased serum serotonin 59 32 very rare (1%) Very rare (<4-1%) HP:0003144
21 tricuspid regurgitation 59 32 very rare (1%) Very rare (<4-1%) HP:0005180
22 increased circulating cortisol level 59 32 very rare (1%) Very rare (<4-1%) HP:0003118
23 palpitations 59 32 very rare (1%) Very rare (<4-1%) HP:0001962
24 night sweats 59 32 very rare (1%) Very rare (<4-1%) HP:0030166
25 cardiogenic shock 59 32 very rare (1%) Very rare (<4-1%) HP:0030149
26 protracted diarrhea 59 32 very rare (1%) Very rare (<4-1%) HP:0004385
27 right ventricular failure 59 32 very rare (1%) Very rare (<4-1%) HP:0001708
28 dermatological manifestations of systemic disorders 59 32 very rare (1%) Very rare (<4-1%) HP:0001005
29 bronchospasm 59 32 very rare (1%) Very rare (<4-1%) HP:0025428
30 bowel urgency 59 32 very rare (1%) Very rare (<4-1%) HP:0012701
31 abnormal pulmonary valve cusp morphology 59 32 very rare (1%) Very rare (<4-1%) HP:0031566

MGI Mouse Phenotypes related to Bronchial Neuroendocrine Tumor:

46 (showing 2, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.13 AVPR1B GHRL RLN1
2 endocrine/exocrine gland MP:0005379 8.8 AVPR1B GHRL RLN1

Drugs & Therapeutics for Bronchial Neuroendocrine Tumor

Drugs for Bronchial Neuroendocrine Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 9, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sirolimus Approved, Investigational Phase 2 53123-88-9 6436030 5284616 46835353
2
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
3
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
4 Antifungal Agents Phase 2
5 Anti-Infective Agents Phase 2
6 Anti-Bacterial Agents Phase 2
7 Immunosuppressive Agents Phase 2
8 Antibiotics, Antitubercular Phase 2
9 Immunologic Factors Phase 2

Interventional clinical trials:

(showing 1, show less)
# Name Status NCT ID Phase Drugs
1 Safety and Tolerability of Everolimus as Second-line Treatment in Poorly Differentiated Neuroendocrine Carcinoma / Neuroendocrine Carcinoma G3 (WHO 2010) and Neuroendocrine Tumor G3 - an Investigator Initiated Phase II Study Recruiting NCT02113800 Phase 2 Everolimus (Afinitor®)

Search NIH Clinical Center for Bronchial Neuroendocrine Tumor

Genetic Tests for Bronchial Neuroendocrine Tumor

Anatomical Context for Bronchial Neuroendocrine Tumor

MalaCards organs/tissues related to Bronchial Neuroendocrine Tumor:

41
Lung, Trachea, Liver, Heart, Bone, Pineal

Publications for Bronchial Neuroendocrine Tumor

Articles related to Bronchial Neuroendocrine Tumor:

(showing 13, show less)
# Title Authors PMID Year
1
Salvage peptide receptor radionuclide therapy with [177Lu-DOTA,Tyr3]octreotate in patients with bronchial and gastroenteropancreatic neuroendocrine tumours. 38
30267116 2019
2
Management and Follow-up of Patients with a Bronchial Neuroendocrine Tumor in the Last Twenty Years in Ireland: Expected Inconsistencies and Unexpected Discoveries. 38
30228817 2018
3
¹⁷⁷Lu-Labeled Agents for Neuroendocrine Tumor Therapy and Bone Pain Palliation in Uruguay. 38
25771367 2016
4
Observational study of patients with gastroenteropancreatic and bronchial neuroendocrine tumors in Argentina: Results from the large database of a multidisciplinary group clinical multicenter study. 38
25054030 2014
5
Glucose-dependent insulinotropic polypeptide receptors in most gastroenteropancreatic and bronchial neuroendocrine tumors. 38
22112810 2012
6
Metastatic bronchial neuroendocrine tumor to the pineal gland: a unique manifestation of a rare disease. 38
20363727 2010
7
Stimulatory effect of growth hormone-releasing hormone (GHRH(1-29)NH2) on the proliferation, VEGF and chromogranin A secretion by human neuroendocrine tumor cell line NCI-H727 in vitro. 38
19747727 2009
8
Carcinoid crisis induced by receptor radionuclide therapy with 90Y-DOTATOC in a case of liver metastases from bronchial neuroendocrine tumor (atypical carcinoid). 38
16840837 2006
9
[Five year remission of GHRH secreting bronchial neuroendocrine tumor with symptoms of acromegaly. Utility of chromogranin A in the monitoring of the disease]. 38
16575760 2006
10
Cyclical Cushing's syndrome in a patient with a bronchial neuroendocrine tumor (typical carcinoid) expressing ghrelin and growth hormone secretagogue receptors. 38
14671177 2003
11
Pulmonary neuroendocrine tumors: incidence and prognosis of histological subtypes. A population-based study in Denmark. 38
12140134 2002
12
[Metastatic gastric calcifications and bronchial neuroendocrine tumor]. 38
11924191 2001
13
Bronchial neuroendocrine (carcinoid) tumor causing unilateral left-sided carcinoid heart disease. 38
2013974 1991

Variations for Bronchial Neuroendocrine Tumor

Expression for Bronchial Neuroendocrine Tumor

Search GEO for disease gene expression data for Bronchial Neuroendocrine Tumor.

Pathways for Bronchial Neuroendocrine Tumor

GO Terms for Bronchial Neuroendocrine Tumor

Biological processes related to Bronchial Neuroendocrine Tumor according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 8.62 GHRL AVPR1B

Molecular functions related to Bronchial Neuroendocrine Tumor according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 RLN1 GHRL

Sources for Bronchial Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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