Aliases & Classifications for Bronchiectasis

MalaCards integrated aliases for Bronchiectasis:

Name: Bronchiectasis 12 77 30 56 6 45 15 64 74
Polynesian Bronchiectasis 12
Kartagener Syndrome 74

Classifications:



External Ids:

Disease Ontology 12 DOID:9563
ICD9CM 36 494
MeSH 45 D001987
NCIt 51 C84475
SNOMED-CT 69 12295008
ICD10 34 J47 J47.9

Summaries for Bronchiectasis

PubMed Health : 64 About bronchiectasis: Bronchiectasis (brong-ke-EK-tah-sis) is a condition in which damage to the airways causes them to widen and become flabby and scarred. The airways are tubes that carry air in and out of your lungs.Bronchiectasis often is caused by an infection or other condition that injures the walls of the airways or prevents the airways from clearing mucus. Mucus is a slimy substance. It helps remove inhaled dust, bacteria, and other small particles from the airways.In bronchiectasis, your airways slowly lose their ability to clear out mucus. The mucus builds up, and bacteria begin to grow. This leads to repeated, serious lung infections.Each infection causes more damage to the airways. Over time, the airways can't properly move air in and out of the lungs. As a result, the body's vital organs might not get enough oxygen.Bronchiectasis can lead to serious health problems, such as respiratory failure, atelectasis (at-eh-LEK-tah-sis), and heart failure.

MalaCards based summary : Bronchiectasis, also known as polynesian bronchiectasis, is related to bronchiectasis with or without elevated sweat chloride 1 and idiopathic bronchiectasis, and has symptoms including headache An important gene associated with Bronchiectasis is STAT1 (Signal Transducer And Activator Of Transcription 1), and among its related pathways/superpathways are Innate Immune System and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Tobramycin and Budesonide have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and testes, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

Wikipedia : 77 Bronchiectasis is a disease in which there is permanent enlargement of parts of the airways of the lung.... more...

Related Diseases for Bronchiectasis

Diseases related to Bronchiectasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 325)
# Related Disease Score Top Affiliating Genes
1 bronchiectasis with or without elevated sweat chloride 1 34.5 CFTR SCNN1B
2 idiopathic bronchiectasis 33.9 CFTR SCNN1A SCNN1B SCNN1G
3 nontuberculous mycobacterial lung disease 31.4 CFTR TLR2
4 bronchitis 30.6 CFTR CXCL8 ELANE MPO SERPINA1
5 respiratory failure 30.4 CXCL8 ELANE SERPINA1
6 pulmonary emphysema 30.3 ELANE MMP8 SERPINA1
7 cystic fibrosis 30.3 BPI CFTR CTSG CXCL8 ELANE MBL2
8 ulcerative colitis 30.1 BPI CXCL8 MPO
9 haemophilus influenzae 30.1 CXCL8 TLR2
10 anca-associated vasculitis 29.9 MPO SERPINA1
11 aspergillosis 29.9 CFTR ELANE MBL2 TLR2
12 alpha-1-antitrypsin deficiency 29.8 BPI CXCL8 ELANE SERPINA1 SERPINA3
13 crescentic glomerulonephritis 29.8 BPI CTSG MPO
14 pneumonia 29.7 CXCL8 ELANE MBL2 MPO TLR2
15 mycobacterium abscessus 29.6 CFTR CXCL8 SERPINA1 TLR2
16 sclerosing cholangitis 29.6 BPI CFTR CTSG MPO
17 vasculitis 29.6 BPI CTSG ELANE MPO SERPINA1
18 pulmonary disease, chronic obstructive 29.2 CFTR CXCL8 ELANE MPO SERPINA1 SERPINA3
19 inflammatory bowel disease 29.1 CXCL8 MPO STAT1 TLR2
20 lung disease 28.7 CFTR CTSG CXCL8 ELANE MBL2 MMP8
21 systemic lupus erythematosus 28.4 CTSG ELANE MBL2 MPO STAT1 TLR2
22 bronchiectasis with or without elevated sweat chloride 3 12.5
23 bronchiectasis with or without elevated sweat chloride 2 12.4
24 ciliary dyskinesia-bronchiectasis 12.2
25 bronchiectasis oligospermia 12.1
26 ciliary dyskinesia, primary, 1 11.9
27 kartagener syndrome 11.9
28 primary ciliary dyskinesia 11.4
29 yellow nail syndrome 11.4
30 panbronchiolitis, diffuse 11.4
31 mounier-kuhn syndrome 11.2
32 bare lymphocyte syndrome, type i 11.2
33 tracheobronchomegaly 11.2
34 ciliary dyskinesia, primary, 25 11.1
35 ciliary dyskinesia, primary, 26 11.1
36 ciliary dyskinesia, primary, 27 11.1
37 ciliary dyskinesia, primary, 28 11.1
38 ciliary dyskinesia, primary, 32 11.1
39 cutis laxa, autosomal dominant 1 11.0
40 young syndrome 11.0
41 ciliary dyskinesia, primary, 9 11.0
42 ciliary dyskinesia, primary, 11 11.0
43 ciliary dyskinesia, primary, 12 11.0
44 ciliary dyskinesia, primary, 22 11.0
45 ciliary dyskinesia, primary, 23 11.0
46 ciliary dyskinesia, primary, 30 11.0
47 ciliary dyskinesia, primary, 36, x-linked 10.9
48 ciliary dyskinesia, primary, 2 10.9
49 ciliary dyskinesia, primary, 3 10.9
50 ciliary dyskinesia, primary, 5 10.9

Comorbidity relations with Bronchiectasis via Phenotypic Disease Network (PDN): (show all 20)


Agammaglobulinemia, X-Linked Anxiety
Aspergillosis Bronchitis
Bronchopneumonia Chronic Pulmonary Heart Disease
Deficiency Anemia Esophagitis
Familial Atrial Fibrillation Heart Disease
Hypothyroidism Idiopathic Interstitial Pneumonia
Lung Abscess Mitral Valve Disease
Osteoporosis Postinflammatory Pulmonary Fibrosis
Protein-Energy Malnutrition Pulmonary Tuberculosis
Respiratory Failure Rheumatoid Arthritis

Graphical network of the top 20 diseases related to Bronchiectasis:



Diseases related to Bronchiectasis

Symptoms & Phenotypes for Bronchiectasis

UMLS symptoms related to Bronchiectasis:


headache

MGI Mouse Phenotypes related to Bronchiectasis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 CFTR CTSG DNAH5 DNAI1 ELANE MBL2
2 immune system MP:0005387 9.96 CFTR CTSG DNAH5 DNAI1 ELANE MBL2
3 digestive/alimentary MP:0005381 9.91 CFTR DNAH5 SCNN1A SCNN1B SCNN1G STAT1
4 mortality/aging MP:0010768 9.9 CFTR CTSG DNAH5 DNAI1 ELANE MPO
5 normal MP:0002873 9.56 CFTR CTSG ELANE SCNN1A SCNN1B SCNN1G
6 respiratory system MP:0005388 9.17 CFTR DNAH5 DNAI1 SCNN1A SCNN1B SCNN1G

Drugs & Therapeutics for Bronchiectasis

PubMedHealth treatment related to Bronchiectasis: 64

Bronchiectasis often is treated with medicines, hydration, and chest physical therapy (CPT). Your doctor may recommend surgery if the bronchiectasis is isolated to a section of lung or you have a lot of bleeding.If the bronchiectasis is widespread and causing respiratory failure, your doctor may recommend oxygen therapy.The goals of treatment are to:Treat any underlying conditions and lung infections.Remove mucus (a slimy substance) from your lungs. Maintaining good hydration helps with mucus removal.Prevent complications.Early diagnosis and treatment of the underlying cause of bronchiectasis may help prevent further lung damage. In addition, any disease associated with the bronchiectasis, such as cystic fibrosis or immunodeficiency, also should be treated.

Drugs for Bronchiectasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 226)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tobramycin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 32986-56-4 36294 5496
2
Budesonide Approved Phase 4,Not Applicable 51333-22-3 5281004 63006
3
Azithromycin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83905-01-5 447043 55185
4
Amoxicillin Approved, Vet_approved Phase 4,Not Applicable 26787-78-0 33613
5
Fluticasone Approved, Experimental Phase 4,Phase 2 90566-53-3 62924
6
Theophylline Approved Phase 4 58-55-9 2153
7
Atorvastatin Approved Phase 4 134523-00-5 60823
8
Amikacin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 37517-28-5 37768
9
Ivacaftor Approved Phase 4,Phase 2 873054-44-5 16220172
10
Acetylcysteine Approved, Investigational Phase 4,Phase 3,Not Applicable 616-91-1 12035
11
Meropenem Approved, Investigational Phase 4 119478-56-7, 96036-03-2 441130 64778
12
Calcium Approved, Nutraceutical Phase 4,Phase 2 7440-70-2 271
13
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
14
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
15
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
16 Andrographolide Investigational Phase 4 5508-58-7
17 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Hormones Phase 4,Phase 3,Not Applicable
20 Bone Density Conservation Agents Phase 4
21 Calcium, Dietary Phase 4,Phase 2
22 Vitamins Phase 4
23 Ergocalciferols Phase 4
24 Trace Elements Phase 4
25 Nutrients Phase 4
26 Vitamin D2 Phase 4
27 Micronutrients Phase 4
28 Calciferol Phase 4
29 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Not Applicable
30 Anticonvulsants Phase 4
31 Bronchodilator Agents Phase 4,Phase 3,Phase 2,Not Applicable
32 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
33 Respiratory System Agents Phase 4,Phase 3,Phase 2,Not Applicable
34 Budesonide, Formoterol Fumarate Drug Combination Phase 4,Not Applicable
35 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
36 Bromides Phase 4
37 Cholinergic Antagonists Phase 4
38 Formoterol Fumarate Phase 4,Phase 3,Not Applicable
39 Parasympatholytics Phase 4
40 Cholinergic Agents Phase 4
41 Tiotropium Bromide Phase 4 136310-93-5
42 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
43 Immunoglobulins Phase 4,Phase 3
44 Vaccines Phase 4,Phase 3
45 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3
46 Immunologic Factors Phase 4,Phase 3,Phase 1
47 Antibodies Phase 4,Phase 3
48 Analgesics Phase 4
49 Antiviral Agents Phase 4,Phase 3,Not Applicable
50 Antiparasitic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 306)
# Name Status NCT ID Phase Drugs
1 A Study to Access Safety and Efficacy of Nebulized Tobramycin in Patients With Bronchiectasis Unknown status NCT01677403 Phase 4 Tobramycin;Saline
2 Vitamin D as an Adjunctive Treatment in Patients With Non-Cystic Fibrosis Bronchiectasis Unknown status NCT02507843 Phase 4 Cholecalciferol;Placebo
3 Comparisons of Inhaled LAMA or ICS+LABA for COPD With Bronchiectasis Unknown status NCT02546297 Phase 4 Symbicort;Tiotropium Bromide
4 Use of Roflumilast to Prevent Exacerbations in Fibrotic Sarcoidosis Patients (REFS) Unknown status NCT01830959 Phase 4 Roflumilast;Placebo
5 Polysaccharide Antibody Response Study Unknown status NCT02429531 Phase 4
6 Evaluate the Efficacy and Safety of Andrographolide Sulfonate in Patients With Acute Bronchitis Unknown status NCT03132623 Phase 4 andrographolide sulfonate;andrographolide sulfonate simulation
7 Prevention of OM-85 on Bronchiectasis Exacerbation Completed NCT01968421 Phase 4 OM-85
8 Salmeterol-Fluticasone Combined Inhaled Therapy for Non-cystic Fibrosis Bronchiectasis Completed NCT02782312 Phase 4 ICS+LABA
9 The Role of Theophylline Plus Low-dose Formoterol-budesonide in Treatment of Bronchiectasis Completed NCT01769898 Phase 4 Formoterol-budesonide;Theophylline;Placebo
10 Efficacy of Azithromycin in Treatment of Bronchiectasis Completed NCT02107274 Phase 4 Azithromycin;Placebo for Azithromycin
11 Is Regular Chest Physiotherapy an Effective Treatment in Severe, Non Cystic Fibrosis Bronchiectasis? Completed NCT00816309 Phase 4
12 The Effect of Theophylline in the Treatment of Bronchiectasis Completed NCT01684683 Phase 4 Theophylline;Placebo(for Theophylline)
13 Atorvastatin in Bronchiectasis in Patients With Pseudomonas Aeruginosa Completed NCT01299194 Phase 4 ATORVASTATIN
14 Combined Administration of Nebulized Amikacin in Patients With Acute Exacerbation of Non-Cystic Fibrosis Bronchiectasis Completed NCT02081963 Phase 4 Amikacin;Normal saline
15 A Trial of Atorvastatin as an Anti-Inflammatory Agent in Non-Cystic Fibrosis Bronchiectasis Completed NCT01299181 Phase 4 Atorvastatin
16 Pulmonary Rehabilitation in Non Cystic Fibrosis Bronchiectasis Completed NCT00868075 Phase 4
17 Long Term Nebulised Gentamicin in Patients With Bronchiectasis Completed NCT00749866 Phase 4 Gentamicin;Saline
18 Effectiveness and Safety of Inhaling Hypertonic Saline in Patients With Chronic Obstructive Pulmonary Disease Completed NCT00639236 Phase 4
19 Efficacy of Temporary Positive Expiratory Pressure (TPEP) in Chronic Hypersecretion Completed NCT00700388 Phase 4
20 Study of Azithromycin for Lymphocytic Bronchiolitis/Bronchitis After Lung Transplantation Completed NCT01109160 Phase 4 Azithromycin Dihydrate
21 Therapy of Bronchoalveolar Lavage and Local Amikacin Injection in Patients With Acute Exacerbation of Bronchiectasis Recruiting NCT02509091 Phase 4 Bronchoalveolar Lavage and Local Amikacin Injection
22 Evaluating the Effects of Traditional Chinese Medicine by N-of-1 Trials Recruiting NCT03147443 Phase 4 Individualized Decoction;placebo;Tested drug minus heat-clearing herbs
23 Hospitalised Pneumonia With Extended Treatment (HOPE) Study Recruiting NCT02783859 Phase 4 Amoxicillin-clavulanic Acid;Placebo (for Amoxicillin-clavulanic Acid)
24 Bacterial Load Guided Therapy for Severe Bronchiectasis Exacerbations Active, not recruiting NCT02047773 Phase 4 Colomycin;Meropenem
25 Immunoglobulin Replacement Therapy for Immunoglobulin G Subclass 2 Deficient Patients With Bronchiectasis Not yet recruiting NCT03737617 Phase 4 Cuvitru 20 % Injectable Solution
26 VX-770 for the Treatment of Chronic Bronchitis Not yet recruiting NCT03251911 Phase 4 Ivacaftor (VX-770)
27 "Nebulized N-Acetyl Cysteine for Bronchiolitis in Inpatient Hospital Use: A Randomized Controlled Trial" Inpatient Hospital Use: A Randomized Controlled Trial" Not yet recruiting NCT03364218 Phase 4 N acetyl cysteine nebulized
28 Bronchiectasis and Long Term Azithromycin Treatment Unknown status NCT00415350 Phase 3 Azithromycin
29 The Efficacy of Azithromycin in Treating Children With Non Cystic Fibrosis Bronchiectasis Unknown status NCT02531984 Phase 3 Azithromycin
30 The Role of Inhalations of Tranexamic Acid in Patients With Hemoptysis Unknown status NCT01496196 Phase 3 tranexamic acid;tranexamic acid
31 An Open Label Trial of Azithromycin in Chronic Productive Cough Unknown status NCT02196493 Phase 3 Azithromycin
32 Ciprofloxacin Dry Powder for Inhalation (DPI) in Non-cystic Fibrosis Bronchiectasis (Non-CF BE) Completed NCT02106832 Phase 3 Ciprofloxacin (BAYQ3939) dry powder for inhalation;Ciprofloxacin (BAYQ3939) dry powder for inhalation;Placebo;Placebo
33 Ciprofloxacin Dry Powder for Inhalation in Non-cystic Fibrosis Bronchiectasis (Non-CF BE) Completed NCT01764841 Phase 3 Ciprofloxacin DPI (BAYQ3939);Placebo
34 Phase 3 Study With Ciprofloxacin Dispersion for Inhalation in Non-CF Bronchiectasis (ORBIT-4) Completed NCT02104245 Phase 3 Ciprofloxacin dispersion for inhalation;Placebo
35 Phase 3 Study With Ciprofloxacin Dispersion for Inhalation in Non-CF Bronchiectasis (ORBIT-3) Completed NCT01515007 Phase 3 Ciprofloxacin dispersion for inhalation;Placebo
36 Safety and Effectiveness of AZLI (an Inhaled Antibiotic) in Adults With Non-Cystic Fibrosis Bronchiectasis Completed NCT01313624 Phase 3 AZLI;Placebo
37 Safety and Effectiveness of AZLI (an Inhaled Antibiotic) in Adults With Non-Cystic Fibrosis Bronchiectasis Completed NCT01314716 Phase 3 AZLI;Placebo
38 Inhaled Mannitol as a Mucoactive Therapy for Bronchiectasis Completed NCT00669331 Phase 3 Inhaled mannitol;Matched control
39 The Long Term Effect of Inhaled Hypertonic Saline (6%) in Patients With Non Cystic Fibrosis Bronchiectasis Completed NCT00484263 Phase 3 Hypertonic saline 6% -
40 Safety and Efficacy of Bronchitol in Bronchiectasis Completed NCT00277537 Phase 3 Mannitol;placebo
41 Efficacy and Safety Study of a Percussion Device to Mobilise Sputum From Respiratory Passage Completed NCT01480882 Phase 2, Phase 3
42 Effects of Roflumilast in Hospitalized Chronic Obstructive Pulmonary Disease( COPD) on Mortality and Re-hospitalization Completed NCT01973998 Phase 3 Roflumilast;Placebo
43 Conjugate Pneumococcal Vaccine in Ataxia Telangiectasia (AT) Completed NCT00656409 Phase 3 Conjugated pneumococcal vaccine (Prevenar)
44 EZ-2053 in the Prophylaxis of Acute Pulmonary Allograft Rejection Completed NCT00105183 Phase 3
45 Therapeutic Confirmatory Clinical Trial to Evaluate the Safety and Efficacy of AG1321001 in Chronic Cougher Completed NCT00380315 Phase 3 AG1321001(drug)
46 Phase 3 Study of Aztreonam for Inhalation Solution (AZLI) in a Continuous Alternating Therapy Regimen for the Treatment of Chronic Pseudomonas Aeruginosa Infection in Patients With CF Completed NCT01641822 Phase 3 AZLI;Placebo to match AZLI;Tobramycin inhalation solution
47 Prevention of Bronchiectasis in Infants With Cystic Fibrosis Recruiting NCT01270074 Phase 3 Azithromycin;Placebo control
48 Formoterol-beclomethasone in Patients With Bronchiectasis: a Randomized Controlled Trial Recruiting NCT03846570 Phase 3 Formoterol-beclomethasone;Placebo
49 Inhaled Nebulized Tobramycin in Non-cystic Fibrosis Bronchiectasis Recruiting NCT02657473 Phase 2, Phase 3 tobramycin inhalation solution;Saline 0.9% inhalation solution
50 Trial in Non-cystic Fibrosis Bronchiectasis Patients With Chronic Lung Infections Treated With Colistimethate Sodium (PROMIS II) Recruiting NCT03460704 Phase 3 Colistimethate sodium;Saline Solution

Search NIH Clinical Center for Bronchiectasis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: bronchiectasis

Genetic Tests for Bronchiectasis

Genetic tests related to Bronchiectasis:

# Genetic test Affiliating Genes
1 Bronchiectasis 30

Anatomical Context for Bronchiectasis

MalaCards organs/tissues related to Bronchiectasis:

42
Lung, Heart, Testes, Neutrophil, Colon, Bone, Thyroid

Publications for Bronchiectasis

Articles related to Bronchiectasis:

(show top 50) (show all 2820)
# Title Authors Year
1
Allergic bronchopulmonary aspergillosis screening in bronchiectasis: is there always a precise answer to a clear question? ( 30638358 )
2019
2
Prevalence of atopy and allergic rhinitis in patients with adult non-cystic fibrosis bronchiectasis ( 30997791 )
2019
3
The Clinical Features of Bronchiectasis Associated with Alpha-1 Antitrypsin Deficiency, Common Variable Immunodeficiency and Primary Ciliary Dyskinesia--Results from the U.S. Bronchiectasis Research Registry. ( 30974050 )
2019
4
Rheumatoid arthritis-associated bronchiectasis. ( 31106745 )
2019
5
Rheumatoid arthritis-associated bronchiectasis - Authors' reply. ( 31106746 )
2019
6
Undetectable mannose binding lectin is associated with HRCT proven bronchiectasis in rheumatoid arthritis (RA). ( 30970022 )
2019
7
Severe uncontrolled asthma with bronchiectasis: a pilot study of an emerging phenotype that responds to mepolizumab. ( 30881051 )
2019
8
Severe asthma and bronchiectasis. ( 30784336 )
2019
9
Bronchiectasis and asthma: a dangerous liaison? ( 30516546 )
2019
10
Bronchiectasis in severe asthma: a distinct phenotype? ( 30461531 )
2019
11
Physical activity associates with disease characteristics of severe asthma, bronchiectasis and COPD. ( 30384396 )
2019
12
Bronchiectasis in COPD and Asthma. More Than Just a Coincidence. ( 30314689 )
2019
13
Case 40-2018: A Woman with Recurrent Sinusitis, Cough, and Bronchiectasis. ( 30943358 )
2019
14
Health-care utilization and expenditures among patients with comorbid bronchiectasis and chronic obstructive pulmonary disease in US clinical practice. ( 30961354 )
2019
15
Clinical characteristics and etiologies of bronchiectasis in Korean children: A multicenter retrospective study. ( 30961955 )
2019
16
Airway Malformations and Bronchiectasis: A Pediatric Study. ( 30974997 )
2019
17
Effect of N-acetylcysteine on exacerbations of bronchiectasis (BENE): a randomized controlled trial. ( 30975143 )
2019
18
Bronchiectasis Guidelines-Recommendations Into Practice. ( 30981551 )
2019
19
Prognostic Value of Concomitant Bronchiectasis in Newly Diagnosed Diffuse Panbronchiolitis Patients on a Maintenance Therapy with Macrolides. ( 30984318 )
2019
20
Comparative risks of chronic inhaled corticosteroids and macrolides for bronchiectasis. ( 31000676 )
2019
21
Bronchiectasis: A Complex, Heterogeneous Disease. ( 31005356 )
2019
22
Mounier-Kuhn syndrome: an unusual cause of bronchiectasis. ( 31019346 )
2019
23
Employment of an algorithm of care including chest physiotherapy results in reduced hospitalizations and stability of lung function in bronchiectasis. ( 31023284 )
2019
24
The airway microbiota in children newly diagnosed with bronchiectasis largely retains its diversity. ( 31023855 )
2019
25
Meta-analysis of macrolide maintenance therapy for prevention of disease exacerbations in patients with noncystic fibrosis bronchiectasis. ( 31027086 )
2019
26
Microbiologic changes observed over 48 weeks of treatment with inhaled liposomal ciprofloxacin in subjects with non-cystic fibrosis bronchiectasis and chronic Pseudomonas aeruginosa lung infection. ( 31035017 )
2019
27
Incidence of patients with non-cystic fibrosis bronchiectasis in Germany - A healthcare insurance claims data analysis. ( 31047108 )
2019
28
Population-based prevalence of bronchiectasis and associated comorbidities in South Korea. ( 31048349 )
2019
29
A longitudinal characterization of the Non-Cystic Fibrosis Bronchiectasis airway microbiome. ( 31053725 )
2019
30
Pulmonary rehabilitation after exacerbation of bronchiectasis: a pilot randomized controlled trial. ( 31060529 )
2019
31
Bronchiectasis in the setting of aplasia of the epiglottis. ( 31061708 )
2019
32
Aberrant right subclavian artery and bibasilar bronchiectasis: is there any association? ( 31061787 )
2019
33
Journal Club - Bronchiectasis/COPD Overlap: Syndrome Versus Treatable Trait? ( 31063276 )
2019
34
Short review on the diagnosis and treatment of bronchiectasis. ( 31086836 )
2019
35
Advances in bronchiectasis. ( 31092516 )
2019
36
Pseudomonas aeruginosa cross-infection: Is this important in bronchiectasis and COPD? ( 31106931 )
2019
37
Airway Bacterial Load and Inhaled Antibiotic Response in Bronchiectasis. ( 31109172 )
2019
38
Distinct "Immunoallertypes" of Disease and High Frequencies of Sensitization in Non-Cystic Fibrosis Bronchiectasis. ( 30265843 )
2019
39
Development of a core outcome set for trials investigating the long-term management of bronchiectasis. ( 30278785 )
2019
40
A New Bronchiectasis Endophenotype: Immunoallertypes. ( 30359084 )
2019
41
Autoimmunity to bactericidal/permeability-increasing protein in bronchiectasis exhibits a requirement for Pseudomonas aeruginosa IgG response. ( 30385530 )
2019
42
Mycobacterium talmoniae, a Potential Pulmonary Pathogen Isolated from Multiple Patients with Bronchiectasis in the United States, Including the First Case of Clinical Disease in a Patient with Cystic Fibrosis. ( 30429252 )
2019
43
Heterogeneity and complexity in bronchiectasis: A pending challenge. ( 30470557 )
2019
44
Atypical Mycobacteria in Bronchiectasis. When do we Treat it? ( 30471918 )
2019
45
Paediatric and adult bronchiectasis: Vaccination in prevention and management. ( 30477047 )
2019
46
Paediatric and adult bronchiectasis: Monitoring, cross-infection, role of multidisciplinary teams and self-management plans. ( 30500093 )
2019
47
Traction bronchiectasis on high-resolution computed tomography may predict fatal acute eosinophilic pneumonia. ( 30528687 )
2019
48
Health Perception and Behaviors in Adults With Bronchiectasis. ( 30538162 )
2019
49
Updated BTS Adult Bronchiectasis Guideline 2018: a multidisciplinary approach to comprehensive care. ( 30545946 )
2019
50
British Thoracic Society Guideline for bronchiectasis in adults. ( 30545985 )
2019

Variations for Bronchiectasis

ClinVar genetic disease variations for Bronchiectasis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 STAT1 NM_007315.3(STAT1): c.1154C> T (p.Thr385Met) single nucleotide variant Pathogenic rs587777630 GRCh37 Chromosome 2, 191851647: 191851647
2 STAT1 NM_007315.3(STAT1): c.1154C> T (p.Thr385Met) single nucleotide variant Pathogenic rs587777630 GRCh38 Chromosome 2, 190986921: 190986921
3 SCNN1A NM_001159576.1(SCNN1A): c.1604G> A (p.Arg535Gln) single nucleotide variant Uncertain significance GRCh37 Chromosome 12, 6458505: 6458505
4 SCNN1A NM_001159576.1(SCNN1A): c.1604G> A (p.Arg535Gln) single nucleotide variant Uncertain significance GRCh38 Chromosome 12, 6349339: 6349339

Expression for Bronchiectasis

Search GEO for disease gene expression data for Bronchiectasis.

Pathways for Bronchiectasis

Pathways related to Bronchiectasis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 BPI CTSG CXCL8 ELANE MBL2 MMP8
2
Show member pathways
12.42 CFTR SCNN1A SCNN1B SCNN1G
3
Show member pathways
12.08 BPI CTSG ELANE TLR2
4
Show member pathways
11.91 CFTR CXCL8 STAT1 TLR2
5
Show member pathways
11.84 CFTR CXCL8 STAT1 TLR2
6
Show member pathways
11.76 SCNN1A SCNN1B SCNN1G
7
Show member pathways
11.65 CTSG ELANE MMP8
8 11.62 CTSG CXCL8 TLR2
9 11 SCNN1A SCNN1B SCNN1G
10 10.8 CFTR SCNN1A SCNN1B SCNN1G
11 10.79 SERPINA3 STAT1
12 10.79 SCNN1A SCNN1B SCNN1G
13 10.04 CFTR SCNN1A SCNN1B SCNN1G

GO Terms for Bronchiectasis

Cellular components related to Bronchiectasis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.97 BPI CTSG ELANE MPO SCNN1A SCNN1B
2 cell surface GO:0009986 9.85 CFTR CTSG ELANE MBL2 TLR2
3 extracellular space GO:0005615 9.81 BPI CTSG CXCL8 ELANE MBL2 MMP8
4 apical plasma membrane GO:0016324 9.8 CFTR SCNN1A SCNN1B SCNN1G
5 secretory granule GO:0030141 9.65 CTSG ELANE MPO
6 collagen-containing extracellular matrix GO:0062023 9.65 CTSG ELANE MMP8 SERPINA1 SERPINA3
7 specific granule lumen GO:0035580 9.58 BPI ELANE MMP8
8 outer dynein arm GO:0036157 9.43 DNAH5 DNAI1
9 sodium channel complex GO:0034706 9.13 SCNN1A SCNN1B SCNN1G
10 azurophil granule lumen GO:0035578 9.02 BPI CTSG ELANE MPO SERPINA3
11 extracellular region GO:0005576 10.02 BPI CTSG CXCL8 ELANE MBL2 MMP8

Biological processes related to Bronchiectasis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.78 CTSG ELANE MPO TLR2
2 sodium ion transport GO:0006814 9.76 SCNN1A SCNN1B SCNN1G
3 neutrophil degranulation GO:0043312 9.76 BPI CTSG ELANE MMP8 MPO SERPINA1
4 defense response to Gram-positive bacterium GO:0050830 9.73 CTSG MBL2 TLR2
5 defense response to bacterium GO:0042742 9.72 BPI CTSG ELANE MBL2 MPO
6 sodium ion transmembrane transport GO:0035725 9.7 SCNN1A SCNN1B SCNN1G
7 extracellular matrix disassembly GO:0022617 9.69 CTSG ELANE MMP8
8 antimicrobial humoral response GO:0019730 9.67 BPI CTSG ELANE
9 sensory perception of taste GO:0050909 9.61 SCNN1A SCNN1B SCNN1G
10 outer dynein arm assembly GO:0036158 9.58 DNAH5 DNAI1
11 acute-phase response GO:0006953 9.58 MBL2 SERPINA1 SERPINA3
12 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.57 STAT1 TLR2
13 response to molecule of bacterial origin GO:0002237 9.55 CXCL8 TLR2
14 positive regulation of immune response GO:0050778 9.54 CTSG ELANE
15 defense response to fungus GO:0050832 9.54 CTSG ELANE MPO
16 response to yeast GO:0001878 9.46 ELANE MPO
17 sodium ion homeostasis GO:0055078 9.43 SCNN1A SCNN1B SCNN1G
18 negative regulation of growth of symbiont in host GO:0044130 9.26 CTSG ELANE MBL2 MPO
19 multicellular organismal water homeostasis GO:0050891 8.92 CFTR SCNN1A SCNN1B SCNN1G

Molecular functions related to Bronchiectasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.33 CTSG ELANE MMP8
2 WW domain binding GO:0050699 9.13 SCNN1A SCNN1B SCNN1G
3 ligand-gated sodium channel activity GO:0015280 8.8 SCNN1A SCNN1B SCNN1G

Sources for Bronchiectasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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